Best TWAS P=1.92e-16 · Best GWAS P=1.06e-13 conditioned to 0.0128
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | BBS7 | 0.19 | 0.21 | bslmm | 423 | 0.23 | 1.8e-27 | -7.37 | -7.5 | 5.2e-14 | 0.93 | 0.00 | 1.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | NUDT6 | 0.04 | 0.04 | lasso | 3 | 0.02 | 6.5e-04 | 5.66 | 5.7 | 1.1e-08 | 0.02 | 0.71 | 0.05 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | TMEM155 | 0.06 | 0.05 | lasso | 3 | 0.02 | 5.5e-04 | -6.04 | -5.6 | 2.1e-08 | 0.68 | 0.12 | 0.82 | FALSE |
4 | GTEx | Adipose Subcutaneous | EXOSC9 | 0.07 | 0.00 | lasso | 2 | 0.00 | 4.5e-01 | -5.66 | 5.4 | 7.8e-08 | -0.83 | 0.05 | 0.34 | FALSE |
5 | GTEx | Artery Tibial | FGF2 | 0.18 | 0.05 | lasso | 3 | 0.02 | 1.3e-02 | 5.64 | 5.9 | 4.2e-09 | -0.01 | 0.08 | 0.09 | TRUE |
6 | GTEx | Artery Tibial | NUDT6 | 0.08 | 0.08 | lasso | 5 | 0.05 | 5.6e-05 | 5.58 | 5.7 | 9.9e-09 | 0.02 | 0.64 | 0.10 | FALSE |
7 | GTEx | Brain Cerebellum | BBS7 | 0.20 | -0.01 | enet | 24 | 0.01 | 2.2e-01 | -5.59 | -5.7 | 9.7e-09 | 0.73 | 0.07 | 0.73 | FALSE |
8 | GTEx | Breast Mammary Tissue | NUDT6 | 0.25 | 0.10 | lasso | 3 | 0.08 | 4.2e-05 | 5.72 | 5.7 | 9.9e-09 | 0.01 | 0.06 | 0.92 | TRUE |
9 | GTEx | Breast Mammary Tissue (Male) | NUDT6 | 0.29 | 0.00 | lasso | 6 | 0.00 | 3.5e-01 | 5.52 | 5.6 | 2.2e-08 | 0.04 | 0.04 | 0.48 | TRUE |
10 | GTEx | Cells EBV-transformed lymphocytes | EXOSC9 | 0.29 | 0.17 | lasso | 7 | 0.16 | 6.6e-06 | 6.71 | 7.3 | 3.2e-13 | -0.68 | 0.24 | 0.72 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | BBS7 | 0.16 | 0.09 | lasso | 7 | 0.16 | 2.9e-12 | -7.43 | -7.8 | 5.2e-15 | 0.91 | 0.00 | 1.00 | FALSE |
12 | GTEx | Colon Transverse | BBS12 | 0.12 | 0.05 | enet | 29 | 0.12 | 3.2e-06 | 0.76 | 5.4 | 8.5e-08 | -0.07 | 0.04 | 0.56 | TRUE |
13 | GTEx | Muscle Skeletal | NUDT6 | 0.15 | 0.12 | lasso | 3 | 0.11 | 1.1e-10 | 5.66 | 5.7 | 1.1e-08 | 0.03 | 0.94 | 0.06 | FALSE |
14 | GTEx | Muscle Skeletal | RP11-170N16.3 | 0.07 | 0.07 | lasso | 3 | 0.06 | 8.8e-07 | 4.92 | 5.6 | 1.9e-08 | 0.04 | 0.27 | 0.72 | FALSE |
15 | GTEx | Nerve Tibial | NUDT6 | 0.11 | 0.08 | lasso | 3 | 0.05 | 2.1e-04 | 5.49 | 5.5 | 4.6e-08 | 0.02 | 0.78 | 0.04 | FALSE |
16 | GTEx | Skin Not Sun Exposed Suprapubic | NUDT6 | 0.07 | 0.02 | lasso | 6 | 0.03 | 1.5e-02 | 4.42 | 5.4 | 7.1e-08 | 0.04 | 0.19 | 0.61 | TRUE |
17 | GTEx | Skin Sun Exposed Lower leg | NUDT6 | 0.11 | 0.08 | lasso | 3 | 0.08 | 6.2e-07 | 5.52 | 5.6 | 2.2e-08 | 0.03 | 0.92 | 0.05 | TRUE |
18 | GTEx | Testis | EXOSC9 | 0.17 | 0.07 | lasso | 8 | 0.10 | 2.5e-05 | -5.68 | 7.3 | 2.7e-13 | -0.87 | 0.01 | 0.98 | FALSE |
19 | ROSMAP | Brain Pre-frontal Cortex | EXOSC9 | 0.05 | 0.02 | lasso | 7 | 0.02 | 5.3e-04 | 4.74 | 5.4 | 6.1e-08 | -0.54 | 0.38 | 0.36 | FALSE |
20 | ROSMAP | Brain Pre-frontal Cortex | NUDT6 | 0.04 | 0.04 | enet | 9 | 0.03 | 2.0e-04 | 5.62 | 5.2 | 2.5e-07 | 0.03 | 0.56 | 0.24 | TRUE |
21 | YFS | Blood | EXOSC9 | 0.06 | 0.09 | bslmm | 401 | 0.09 | 7.0e-28 | 6.58 | 7.1 | 1.4e-12 | -0.63 | 0.44 | 0.56 | FALSE |
22 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EXOSC9 | 0.03 | 0.04 | enet | 9 | 0.04 | 2.8e-08 | 6.92 | 7.5 | 4.7e-14 | -0.70 | 0.17 | 0.83 | FALSE |
23 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NUDT6 | 0.02 | 0.02 | lasso | 4 | 0.01 | 5.4e-03 | 5.58 | 5.6 | 2.2e-08 | 0.04 | 0.13 | 0.18 | FALSE |
24 | The Cancer Genome Atlas | Colon Adenocarcinoma | BBS7 | 0.05 | 0.00 | blup | 47 | 0.02 | 1.9e-02 | 6.96 | -6.8 | 1.0e-11 | 0.56 | 0.02 | 0.16 | FALSE |
25 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BBS7 | 0.04 | 0.02 | blup | 47 | 0.03 | 1.3e-04 | -5.65 | -5.6 | 2.2e-08 | 0.91 | 0.05 | 0.91 | FALSE |
26 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CCNA2 | 0.03 | 0.01 | blup | 34 | 0.02 | 1.5e-03 | -7.33 | 8.2 | 1.9e-16 | -0.80 | 0.00 | 0.97 | TRUE |
27 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | BBS7 | 0.04 | 0.04 | lasso | 2 | 0.03 | 6.1e-04 | -7.37 | -7.4 | 1.6e-13 | 1.00 | 0.00 | 1.00 | FALSE |
28 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FGF2 | 0.06 | 0.04 | blup | 65 | 0.05 | 4.4e-06 | 6.14 | 5.5 | 2.9e-08 | -0.03 | 0.01 | 0.99 | TRUE |
29 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | EXOSC9 | 0.03 | 0.02 | lasso | 2 | 0.02 | 1.0e-03 | 6.66 | 7.2 | 4.3e-13 | -0.66 | 0.08 | 0.36 | FALSE |
30 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NUDT6 | 0.10 | 0.07 | lasso | 6 | 0.07 | 1.0e-07 | 5.58 | 5.2 | 1.6e-07 | 0.02 | 0.92 | 0.08 | FALSE |
31 | The Cancer Genome Atlas | Thyroid Carcinoma | EXOSC9 | 0.04 | 0.05 | lasso | 2 | 0.04 | 7.1e-05 | 6.92 | 7.8 | 6.7e-15 | -0.78 | 0.03 | 0.95 | FALSE |