[Hub]/) : Traits : Arm predicted mass (left) :

chr4:121,982,122-124,538,705

Best TWAS P=1.92e-16 · Best GWAS P=1.06e-13 conditioned to 0.0128

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex BBS7 0.19 0.21 bslmm 423 0.23 1.8e-27 -7.37 -7.5 5.2e-14 0.93 0.00 1.00 FALSE
2 CommonMind Brain Pre-frontal Cortex NUDT6 0.04 0.04 lasso 3 0.02 6.5e-04 5.66 5.7 1.1e-08 0.02 0.71 0.05 FALSE
3 CommonMind Brain Pre-frontal Cortex TMEM155 0.06 0.05 lasso 3 0.02 5.5e-04 -6.04 -5.6 2.1e-08 0.68 0.12 0.82 FALSE
4 GTEx Adipose Subcutaneous EXOSC9 0.07 0.00 lasso 2 0.00 4.5e-01 -5.66 5.4 7.8e-08 -0.83 0.05 0.34 FALSE
5 GTEx Artery Tibial FGF2 0.18 0.05 lasso 3 0.02 1.3e-02 5.64 5.9 4.2e-09 -0.01 0.08 0.09 TRUE
6 GTEx Artery Tibial NUDT6 0.08 0.08 lasso 5 0.05 5.6e-05 5.58 5.7 9.9e-09 0.02 0.64 0.10 FALSE
7 GTEx Brain Cerebellum BBS7 0.20 -0.01 enet 24 0.01 2.2e-01 -5.59 -5.7 9.7e-09 0.73 0.07 0.73 FALSE
8 GTEx Breast Mammary Tissue NUDT6 0.25 0.10 lasso 3 0.08 4.2e-05 5.72 5.7 9.9e-09 0.01 0.06 0.92 TRUE
9 GTEx Breast Mammary Tissue (Male) NUDT6 0.29 0.00 lasso 6 0.00 3.5e-01 5.52 5.6 2.2e-08 0.04 0.04 0.48 TRUE
10 GTEx Cells EBV-transformed lymphocytes EXOSC9 0.29 0.17 lasso 7 0.16 6.6e-06 6.71 7.3 3.2e-13 -0.68 0.24 0.72 FALSE
11 GTEx Cells Transformed fibroblasts BBS7 0.16 0.09 lasso 7 0.16 2.9e-12 -7.43 -7.8 5.2e-15 0.91 0.00 1.00 FALSE
12 GTEx Colon Transverse BBS12 0.12 0.05 enet 29 0.12 3.2e-06 0.76 5.4 8.5e-08 -0.07 0.04 0.56 TRUE
13 GTEx Muscle Skeletal NUDT6 0.15 0.12 lasso 3 0.11 1.1e-10 5.66 5.7 1.1e-08 0.03 0.94 0.06 FALSE
14 GTEx Muscle Skeletal RP11-170N16.3 0.07 0.07 lasso 3 0.06 8.8e-07 4.92 5.6 1.9e-08 0.04 0.27 0.72 FALSE
15 GTEx Nerve Tibial NUDT6 0.11 0.08 lasso 3 0.05 2.1e-04 5.49 5.5 4.6e-08 0.02 0.78 0.04 FALSE
16 GTEx Skin Not Sun Exposed Suprapubic NUDT6 0.07 0.02 lasso 6 0.03 1.5e-02 4.42 5.4 7.1e-08 0.04 0.19 0.61 TRUE
17 GTEx Skin Sun Exposed Lower leg NUDT6 0.11 0.08 lasso 3 0.08 6.2e-07 5.52 5.6 2.2e-08 0.03 0.92 0.05 TRUE
18 GTEx Testis EXOSC9 0.17 0.07 lasso 8 0.10 2.5e-05 -5.68 7.3 2.7e-13 -0.87 0.01 0.98 FALSE
19 ROSMAP Brain Pre-frontal Cortex EXOSC9 0.05 0.02 lasso 7 0.02 5.3e-04 4.74 5.4 6.1e-08 -0.54 0.38 0.36 FALSE
20 ROSMAP Brain Pre-frontal Cortex NUDT6 0.04 0.04 enet 9 0.03 2.0e-04 5.62 5.2 2.5e-07 0.03 0.56 0.24 TRUE
21 YFS Blood EXOSC9 0.06 0.09 bslmm 401 0.09 7.0e-28 6.58 7.1 1.4e-12 -0.63 0.44 0.56 FALSE
22 The Cancer Genome Atlas Breast Invasive Carcinoma EXOSC9 0.03 0.04 enet 9 0.04 2.8e-08 6.92 7.5 4.7e-14 -0.70 0.17 0.83 FALSE
23 The Cancer Genome Atlas Breast Invasive Carcinoma NUDT6 0.02 0.02 lasso 4 0.01 5.4e-03 5.58 5.6 2.2e-08 0.04 0.13 0.18 FALSE
24 The Cancer Genome Atlas Colon Adenocarcinoma BBS7 0.05 0.00 blup 47 0.02 1.9e-02 6.96 -6.8 1.0e-11 0.56 0.02 0.16 FALSE
25 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma BBS7 0.04 0.02 blup 47 0.03 1.3e-04 -5.65 -5.6 2.2e-08 0.91 0.05 0.91 FALSE
26 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CCNA2 0.03 0.01 blup 34 0.02 1.5e-03 -7.33 8.2 1.9e-16 -0.80 0.00 0.97 TRUE
27 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma BBS7 0.04 0.04 lasso 2 0.03 6.1e-04 -7.37 -7.4 1.6e-13 1.00 0.00 1.00 FALSE
28 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FGF2 0.06 0.04 blup 65 0.05 4.4e-06 6.14 5.5 2.9e-08 -0.03 0.01 0.99 TRUE
29 The Cancer Genome Atlas Lung Squamous Cell Carcinoma EXOSC9 0.03 0.02 lasso 2 0.02 1.0e-03 6.66 7.2 4.3e-13 -0.66 0.08 0.36 FALSE
30 The Cancer Genome Atlas Prostate Adenocarcinoma NUDT6 0.10 0.07 lasso 6 0.07 1.0e-07 5.58 5.2 1.6e-07 0.02 0.92 0.08 FALSE
31 The Cancer Genome Atlas Thyroid Carcinoma EXOSC9 0.04 0.05 lasso 2 0.04 7.1e-05 6.92 7.8 6.7e-15 -0.78 0.03 0.95 FALSE