Best TWAS P=2.48e-22 · Best GWAS P=1.09e-21 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | BAIAP2L2 | 0.11 | 0.03 | lasso | 5 | 0.04 | 1.8e-04 | 7.5 | -9.0 | 1.7e-19 | -0.75 | 0.05 | 0.79 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | TMEM184B | 0.08 | 0.08 | lasso | 4 | 0.07 | 1.0e-06 | 5.4 | -6.6 | 4.7e-11 | -0.57 | 0.84 | 0.11 | FALSE |
| 3 | GTEx | Artery Aorta | C22orf23 | 0.10 | 0.01 | enet | 24 | 0.02 | 1.6e-02 | 2.5 | 6.2 | 5.7e-10 | 0.34 | 0.25 | 0.11 | FALSE |
| 4 | GTEx | Artery Aorta | PLA2G6 | 0.10 | 0.02 | enet | 9 | 0.02 | 4.5e-02 | 5.2 | 8.3 | 1.0e-16 | 0.67 | 0.06 | 0.68 | FALSE |
| 5 | GTEx | Artery Aorta | TMEM184B | 0.17 | 0.07 | enet | 34 | 0.03 | 1.2e-02 | 8.6 | -8.4 | 4.6e-17 | -0.67 | 0.08 | 0.66 | FALSE |
| 6 | GTEx | Artery Aorta | AL021977.1 | 0.13 | 0.00 | enet | 17 | 0.01 | 8.7e-02 | 8.8 | -9.1 | 6.8e-20 | -0.73 | 0.03 | 0.78 | FALSE |
| 7 | GTEx | Brain Cortex | TMEM184B | 0.29 | 0.12 | lasso | 7 | 0.09 | 1.6e-03 | 8.6 | -8.9 | 5.3e-19 | -0.90 | 0.01 | 0.90 | FALSE |
| 8 | GTEx | Cells EBV-transformed lymphocytes | PLA2G6 | 0.28 | 0.17 | enet | 13 | 0.18 | 1.3e-06 | -7.4 | 8.2 | 2.6e-16 | 0.70 | 0.23 | 0.64 | FALSE |
| 9 | GTEx | Cells Transformed fibroblasts | ANKRD54 | 0.11 | 0.09 | lasso | 4 | 0.09 | 5.3e-07 | -5.6 | -5.7 | 9.7e-09 | -0.20 | 0.81 | 0.02 | TRUE |
| 10 | GTEx | Cells Transformed fibroblasts | PLA2G6 | 0.23 | 0.09 | lasso | 9 | 0.10 | 9.9e-08 | 7.4 | 8.3 | 7.3e-17 | 0.83 | 0.60 | 0.40 | FALSE |
| 11 | GTEx | Cells Transformed fibroblasts | MAFF | 0.08 | 0.08 | lasso | 3 | 0.06 | 2.2e-05 | 6.3 | -5.3 | 1.4e-07 | -0.71 | 0.35 | 0.24 | FALSE |
| 12 | GTEx | Cells Transformed fibroblasts | TMEM184B | 0.17 | 0.16 | lasso | 5 | 0.14 | 2.1e-10 | 5.4 | -6.2 | 6.2e-10 | -0.51 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Cells Transformed fibroblasts | AL021977.1 | 0.08 | 0.08 | enet | 7 | 0.06 | 2.4e-05 | 5.4 | -5.5 | 3.1e-08 | -0.48 | 0.83 | 0.09 | FALSE |
| 14 | GTEx | Colon Sigmoid | TMEM184B | 0.20 | 0.03 | lasso | 4 | -0.01 | 5.4e-01 | 5.4 | -5.5 | 3.5e-08 | -0.42 | 0.10 | 0.16 | FALSE |
| 15 | GTEx | Esophagus Gastroesophageal Junction | PLA2G6 | 0.28 | 0.24 | lasso | 5 | 0.23 | 1.1e-08 | -7.4 | 7.9 | 2.1e-15 | 0.65 | 0.75 | 0.13 | FALSE |
| 16 | GTEx | Esophagus Mucosa | PLA2G6 | 0.22 | 0.02 | lasso | 6 | 0.04 | 1.9e-03 | 7.4 | 8.2 | 3.0e-16 | 0.80 | 0.05 | 0.94 | FALSE |
| 17 | GTEx | Esophagus Muscularis | PLA2G6 | 0.12 | 0.00 | enet | 18 | 0.01 | 1.4e-01 | 7.4 | 7.3 | 3.7e-13 | 0.61 | 0.07 | 0.39 | TRUE |
| 18 | GTEx | Esophagus Muscularis | TMEM184B | 0.11 | 0.01 | enet | 10 | 0.06 | 2.7e-04 | 3.6 | -6.4 | 1.6e-10 | -0.60 | 0.26 | 0.21 | TRUE |
| 19 | GTEx | Muscle Skeletal | ANKRD54 | 0.15 | 0.02 | enet | 21 | 0.04 | 1.1e-04 | -5.6 | -5.4 | 6.0e-08 | -0.15 | 0.88 | 0.00 | TRUE |
| 20 | GTEx | Muscle Skeletal | DMC1 | 0.13 | 0.01 | enet | 17 | 0.04 | 3.3e-05 | 7.5 | 6.4 | 1.4e-10 | 0.58 | 0.03 | 0.86 | FALSE |
| 21 | GTEx | Nerve Tibial | PLA2G6 | 0.34 | 0.08 | lasso | 8 | 0.11 | 2.9e-08 | -7.4 | 8.3 | 1.5e-16 | 0.74 | 0.94 | 0.06 | FALSE |
| 22 | GTEx | Nerve Tibial | MAFF | 0.14 | 0.06 | lasso | 3 | 0.05 | 1.2e-04 | 9.5 | -9.4 | 4.3e-21 | -0.99 | 0.00 | 0.99 | FALSE |
| 23 | GTEx | Nerve Tibial | TMEM184B | 0.16 | 0.12 | lasso | 7 | 0.14 | 3.6e-10 | 5.4 | -5.7 | 1.2e-08 | -0.44 | 0.99 | 0.00 | FALSE |
| 24 | GTEx | Nerve Tibial | AL021977.1 | 0.16 | 0.05 | lasso | 3 | 0.07 | 9.3e-06 | 5.4 | -6.8 | 1.3e-11 | -0.60 | 0.55 | 0.42 | FALSE |
| 25 | GTEx | Skin Sun Exposed Lower leg | ANKRD54 | 0.07 | 0.04 | enet | 17 | 0.04 | 1.6e-04 | -5.6 | -5.5 | 5.0e-08 | -0.21 | 0.46 | 0.08 | FALSE |
| 26 | GTEx | Skin Sun Exposed Lower leg | BAIAP2L2 | 0.09 | 0.09 | lasso | 4 | 0.09 | 5.5e-08 | 6.9 | -7.4 | 1.7e-13 | -0.77 | 0.23 | 0.77 | FALSE |
| 27 | GTEx | Thyroid | PLA2G6 | 0.34 | 0.20 | lasso | 5 | 0.18 | 4.5e-14 | -7.4 | 8.2 | 3.6e-16 | 0.68 | 1.00 | 0.00 | FALSE |
| 28 | GTEx | Thyroid | TMEM184B | 0.19 | 0.16 | lasso | 7 | 0.18 | 1.0e-13 | 5.4 | -7.2 | 7.1e-13 | -0.66 | 0.99 | 0.01 | FALSE |
| 29 | GTEx | Thyroid | AL021977.1 | 0.20 | 0.11 | lasso | 6 | 0.12 | 2.7e-09 | 5.4 | -7.5 | 6.3e-14 | -0.65 | 0.96 | 0.04 | FALSE |
| 30 | ROSMAP | Brain Pre-frontal Cortex | ANKRD54 | 0.03 | 0.00 | blup | 397 | 0.01 | 2.2e-02 | 1.9 | -5.9 | 3.0e-09 | -0.27 | 0.19 | 0.06 | FALSE |
| 31 | YFS | Blood | TMEM184B | 0.09 | 0.07 | enet | 38 | 0.09 | 7.8e-28 | 5.2 | -6.0 | 2.0e-09 | -0.52 | 1.00 | 0.00 | FALSE |
| 32 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ANKRD54 | 0.20 | 0.06 | lasso | 1 | 0.06 | 3.0e-07 | -5.6 | -5.6 | 2.1e-08 | -0.17 | 0.00 | 1.00 | TRUE |
| 33 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PLA2G6 | 0.05 | 0.01 | blup | 76 | 0.01 | 7.7e-02 | 9.4 | 9.7 | 2.5e-22 | 0.85 | 0.01 | 0.82 | TRUE |
| 34 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TMEM184B | 0.03 | 0.03 | lasso | 2 | 0.03 | 7.7e-05 | 5.2 | -5.4 | 7.2e-08 | -0.44 | 0.24 | 0.18 | FALSE |
| 35 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BAIAP2L2 | 0.05 | 0.01 | blup | 52 | 0.03 | 3.7e-04 | 2.7 | -5.9 | 3.4e-09 | -0.44 | 0.08 | 0.25 | FALSE |
| 36 | The Cancer Genome Atlas | Thyroid Carcinoma | PLA2G6 | 0.03 | 0.02 | lasso | 2 | 0.03 | 6.5e-04 | 8.3 | 8.3 | 8.3e-17 | 0.82 | 0.09 | 0.18 | FALSE |
| 37 | The Cancer Genome Atlas | Thyroid Carcinoma | TMEM184B | 0.03 | 0.04 | lasso | 2 | 0.04 | 1.6e-04 | 5.4 | -5.4 | 6.2e-08 | -0.44 | 0.15 | 0.21 | FALSE |