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chr22:40,903,421-42,917,154

Best TWAS P=5.17e-10 · Best GWAS P=1.28e-09 conditioned to 0.27

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CSDC2	0.20	0.30	lasso	5	0.32	2.1e-40	5.2	5.5	3.7e-08	0.92	0.14	0.86	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MEI1	0.09	0.10	blup	343	0.10	3.1e-12	5.2	6.0	1.9e-09	0.84	0.33	0.67	FALSE
3	CommonMind	Brain Pre-frontal Cortex	POLR3H	0.24	0.31	enet	24	0.35	1.3e-44	5.7	5.4	8.7e-08	0.92	0.03	0.97	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TOB2	0.02	0.01	bslmm	278	0.01	3.5e-02	6.0	5.6	2.8e-08	0.90	0.05	0.91	FALSE
5	GTEx	Artery Aorta	ACO2	0.08	0.08	lasso	5	0.06	2.8e-04	5.9	5.9	4.6e-09	0.94	0.04	0.91	FALSE
6	GTEx	Artery Tibial	ACO2	0.06	0.02	enet	15	0.06	1.2e-05	5.7	5.8	6.4e-09	0.78	0.04	0.95	FALSE
7	GTEx	Brain Caudate basal ganglia	CSDC2	0.13	0.03	enet	9	0.08	2.0e-03	3.1	5.4	5.8e-08	0.75	0.07	0.66	FALSE
8	GTEx	Brain Cerebellar Hemisphere	POLR3H	0.10	0.08	lasso	7	0.08	4.9e-03	5.6	5.6	1.8e-08	0.93	0.09	0.61	FALSE
9	GTEx	Brain Cortex	POLR3H	0.27	0.21	lasso	8	0.18	8.5e-06	5.6	5.7	1.0e-08	0.94	0.07	0.92	FALSE
10	GTEx	Brain Cortex	CSDC2	0.31	0.32	lasso	5	0.28	1.8e-08	5.4	5.4	5.8e-08	0.91	0.27	0.72	FALSE
11	GTEx	Brain Frontal Cortex BA9	POLR3H	0.13	0.09	lasso	7	0.04	3.4e-02	5.6	5.6	1.9e-08	0.93	0.06	0.74	FALSE
12	GTEx	Brain Frontal Cortex BA9	CSDC2	0.25	0.23	lasso	8	0.24	3.8e-07	5.9	5.7	9.2e-09	0.95	0.06	0.94	FALSE
13	GTEx	Brain Hippocampus	POLR3H	0.16	0.11	lasso	14	0.05	2.4e-02	5.6	5.7	1.0e-08	0.95	0.06	0.69	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	CSDC2	0.25	0.28	lasso	2	0.29	1.8e-08	5.7	5.5	3.8e-08	0.92	0.15	0.85	FALSE
15	GTEx	Brain Putamen basal ganglia	CSDC2	0.19	0.06	lasso	4	0.13	5.3e-04	5.1	5.2	1.7e-07	0.87	0.09	0.58	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	PMM1	0.20	0.16	lasso	7	0.14	1.9e-05	5.9	-5.7	9.8e-09	-0.93	0.06	0.93	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	TEF	0.23	0.13	lasso	7	0.16	6.9e-06	5.9	5.9	4.4e-09	0.96	0.04	0.96	FALSE
18	GTEx	Cells Transformed fibroblasts	PMM1	0.12	0.07	enet	15	0.11	1.0e-08	5.4	-5.4	7.1e-08	-0.82	0.28	0.71	FALSE
19	GTEx	Esophagus Mucosa	L3MBTL2	0.16	0.11	enet	17	0.12	3.4e-08	-4.2	5.3	1.1e-07	0.60	0.87	0.12	FALSE
20	GTEx	Esophagus Mucosa	PMM1	0.05	0.00	enet	14	0.01	7.1e-02	5.7	-5.4	8.4e-08	-0.79	0.08	0.77	FALSE
21	GTEx	Esophagus Muscularis	PMM1	0.07	0.05	lasso	5	0.05	6.8e-04	5.4	-5.7	9.6e-09	-0.92	0.18	0.79	FALSE
22	GTEx	Muscle Skeletal	PMM1	0.04	0.03	lasso	3	0.02	1.8e-03	5.4	-5.5	3.2e-08	-0.87	0.20	0.74	FALSE
23	GTEx	Nerve Tibial	ACO2	0.06	0.05	lasso	5	0.04	8.5e-04	5.9	6.2	5.2e-10	0.90	0.03	0.96	TRUE
24	GTEx	Ovary	ACO2	0.14	0.12	lasso	3	0.13	4.5e-04	5.6	5.2	1.9e-07	0.88	0.06	0.82	FALSE
25	GTEx	Stomach	DESI1	0.12	0.07	enet	14	0.06	4.9e-04	5.6	5.6	2.7e-08	0.88	0.08	0.90	FALSE
26	GTEx	Testis	CCDC134	0.20	0.29	lasso	20	0.26	4.9e-12	5.3	-5.6	2.1e-08	-0.90	0.25	0.75	FALSE
27	GTEx	Testis	POLR3H	0.32	0.51	enet	9	0.51	5.6e-26	5.6	5.6	2.1e-08	0.92	0.13	0.87	FALSE
28	GTEx	Testis	TEF	0.06	0.05	lasso	5	0.04	5.5e-03	5.3	5.4	6.1e-08	0.91	0.07	0.83	FALSE
29	GTEx	Testis	RP5-821D11.7	0.15	0.16	lasso	8	0.12	9.0e-06	5.5	-5.8	8.5e-09	-0.86	0.14	0.86	FALSE
30	GTEx	Thyroid	ACO2	0.08	0.09	lasso	6	0.10	9.6e-08	6.1	6.1	1.3e-09	0.99	0.03	0.97	FALSE
31	GTEx	Uterus	ACO2	0.13	0.06	enet	31	0.08	9.5e-03	5.9	5.9	4.3e-09	0.91	0.08	0.69	FALSE
32	GTEx	Vagina	PMM1	0.25	0.13	lasso	4	0.14	5.3e-04	5.7	-5.2	1.9e-07	-0.91	0.05	0.69	FALSE
33	NTR	Blood	TEF	0.01	0.02	lasso	2	0.02	3.8e-06	5.4	5.4	5.9e-08	0.89	0.07	0.93	FALSE
34	YFS	Blood	MEI1	0.09	0.18	lasso	21	0.19	2.7e-59	5.3	5.9	2.9e-09	0.96	0.15	0.85	FALSE
35	YFS	Blood	TEF	0.09	0.17	lasso	2	0.17	9.0e-53	5.6	5.6	1.9e-08	0.92	0.13	0.87	FALSE
36	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PMM1	0.04	0.03	lasso	6	0.02	6.1e-03	5.6	-5.6	1.8e-08	-0.93	0.01	0.76	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	MEI1	0.01	0.01	blup	62	0.01	1.1e-02	5.5	5.4	5.9e-08	0.82	0.02	0.93	FALSE
38	The Cancer Genome Atlas	Colon Adenocarcinoma	MEI1	0.05	0.00	blup	64	0.03	1.1e-02	5.5	5.3	9.7e-08	0.75	0.02	0.53	FALSE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	PMM1	0.20	0.06	lasso	1	0.05	6.6e-04	5.3	-5.3	1.2e-07	-0.87	0.02	0.48	FALSE
40	The Cancer Genome Atlas	Colon Adenocarcinoma	TEF	0.04	0.03	blup	36	0.03	9.5e-03	6.0	5.7	1.4e-08	0.95	0.02	0.79	FALSE
41	The Cancer Genome Atlas	Glioblastoma Multiforme	MEI1	0.26	0.22	lasso	4	0.21	5.3e-07	5.5	5.8	8.3e-09	0.85	0.03	0.97	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MEI1	0.03	0.01	blup	64	0.02	3.8e-03	5.4	5.3	1.2e-07	0.80	0.02	0.85	FALSE
43	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PMM1	0.02	0.02	blup	18	0.02	3.9e-03	5.4	-5.6	2.5e-08	-0.91	0.01	0.73	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POLR3H	0.04	0.04	blup	22	0.04	6.8e-05	5.8	-6.2	6.4e-10	-0.91	0.01	0.98	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MEI1	0.04	0.05	blup	61	0.05	5.5e-06	5.5	5.4	7.3e-08	0.87	0.03	0.97	FALSE
46	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ACO2	0.03	0.01	blup	41	0.04	3.9e-03	-2.7	5.9	3.9e-09	0.91	0.02	0.57	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	MEI1	0.08	0.08	blup	60	0.08	6.9e-10	5.5	5.3	1.3e-07	0.82	0.02	0.98	FALSE
48	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MEI1	0.06	0.05	blup	62	0.08	2.0e-04	5.2	5.7	1.5e-08	0.84	0.03	0.87	FALSE
49	The Cancer Genome Atlas	Lung Adenocarcinoma	PMM1	0.02	0.03	lasso	5	0.02	1.1e-03	5.7	-5.7	1.6e-08	-0.93	0.01	0.89	FALSE
50	The Cancer Genome Atlas	Lung Adenocarcinoma	POLR3H	0.03	0.01	blup	26	0.01	6.4e-02	5.6	-6.0	2.2e-09	-0.92	0.01	0.89	FALSE
51	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PHF5A	0.03	0.00	blup	30	0.01	2.9e-02	5.9	5.3	9.1e-08	0.87	0.01	0.55	FALSE
52	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PMM1	0.02	0.01	blup	19	0.02	4.0e-03	5.3	-5.6	1.7e-08	-0.89	0.02	0.73	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TOB2	0.03	0.00	blup	28	0.02	3.4e-03	5.9	6.2	7.2e-10	0.92	0.01	0.56	FALSE
54	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PMM1	0.05	0.06	blup	18	0.06	4.1e-05	5.5	-5.6	2.2e-08	-0.91	0.02	0.98	FALSE
55	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PMM1	0.08	0.08	blup	23	0.09	1.1e-04	5.3	-5.5	3.9e-08	-0.90	0.02	0.94	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	MEI1	0.02	0.02	blup	69	0.01	1.5e-02	5.5	5.3	1.1e-07	0.85	0.02	0.86	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	POLR3H	0.04	0.05	blup	27	0.05	3.4e-06	5.8	-5.3	8.9e-08	-0.90	0.01	0.99	FALSE
58	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TEF	0.30	0.06	blup	36	0.09	1.8e-03	5.3	5.7	1.5e-08	0.85	0.03	0.45	FALSE
59	The Cancer Genome Atlas	Stomach Adenocarcinoma	C22orf46	0.02	0.03	blup	25	0.03	5.5e-03	5.3	-5.5	3.2e-08	-0.87	0.01	0.81	FALSE
60	The Cancer Genome Atlas	Stomach Adenocarcinoma	MEI1	0.04	0.04	enet	4	0.03	2.5e-03	5.5	5.4	5.1e-08	0.87	0.02	0.92	FALSE
61	The Cancer Genome Atlas	Stomach Adenocarcinoma	POLR3H	0.04	0.06	lasso	1	0.04	4.8e-04	5.5	-5.5	4.9e-08	-0.86	0.02	0.87	FALSE
62	The Cancer Genome Atlas	Testicular Germ Cell Tumors	POLR3H	0.10	0.02	blup	23	0.06	3.4e-03	5.6	-5.5	3.4e-08	-0.88	0.01	0.79	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	MEI1	0.02	0.03	enet	2	0.02	2.3e-03	5.4	5.4	7.5e-08	0.87	0.03	0.82	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	PMM1	0.09	0.11	blup	22	0.10	4.6e-10	5.3	-5.6	2.3e-08	-0.90	0.04	0.96	FALSE
65	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	PMM1	0.08	0.07	blup	24	0.05	1.8e-02	5.4	-5.6	2.3e-08	-0.89	0.01	0.56	FALSE