Best TWAS P=1.46e-16 · Best GWAS P=4e-17 conditioned to 0.833
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | TMEM9B | 0.12 | 0.03 | enet | 18 | 0.06 | 2.8e-04 | 6.82 | 5.2 | 1.9e-07 | -0.15 | 0.01 | 0.85 | FALSE |
2 | GTEx | Brain Cortex | ZNF143 | 0.27 | 0.13 | lasso | 5 | 0.10 | 7.8e-04 | -6.25 | -5.2 | 2.3e-07 | 0.15 | 0.04 | 0.72 | FALSE |
3 | GTEx | Brain Cortex | RP11-152H18.3 | 0.41 | 0.04 | enet | 25 | 0.11 | 7.6e-04 | 3.93 | -6.0 | 1.7e-09 | 0.03 | 0.05 | 0.61 | TRUE |
4 | GTEx | Cells Transformed fibroblasts | AMPD3 | 0.20 | 0.02 | lasso | 8 | 0.01 | 5.5e-02 | -5.01 | 5.2 | 1.6e-07 | -0.22 | 0.30 | 0.03 | FALSE |
5 | GTEx | Prostate | SBF2 | 0.21 | 0.05 | lasso | 7 | 0.03 | 6.7e-02 | 7.75 | 8.1 | 7.1e-16 | -0.86 | 0.04 | 0.77 | FALSE |
6 | GTEx | Testis | SBF2 | 0.10 | 0.01 | lasso | 5 | 0.02 | 5.0e-02 | 7.26 | -7.7 | 1.0e-14 | 0.82 | 0.07 | 0.82 | FALSE |
7 | METSIM | Adipose | AMPD3 | 0.06 | 0.03 | enet | 14 | 0.05 | 7.8e-08 | 4.09 | 5.2 | 2.6e-07 | -0.08 | 0.96 | 0.00 | TRUE |
8 | NTR | Blood | ADM | 0.04 | 0.04 | enet | 13 | 0.04 | 1.6e-13 | 7.72 | -8.3 | 1.5e-16 | 0.88 | 0.09 | 0.91 | TRUE |
9 | NTR | Blood | WEE1 | 0.02 | 0.00 | bslmm | 367 | 0.00 | 1.0e-02 | 0.36 | -6.2 | 5.7e-10 | 0.33 | 0.10 | 0.20 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | SBF2-AS1 | 0.03 | 0.00 | bslmm | 362 | 0.01 | 4.4e-03 | -1.73 | 7.2 | 5.8e-13 | -0.59 | 0.04 | 0.63 | FALSE |
11 | YFS | Blood | ADM | 0.08 | 0.11 | enet | 25 | 0.12 | 9.4e-36 | 7.92 | -7.9 | 2.3e-15 | 0.85 | 0.10 | 0.90 | FALSE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZNF143 | 0.02 | 0.02 | lasso | 2 | 0.02 | 4.5e-03 | 6.55 | -6.7 | 2.3e-11 | 0.07 | 0.01 | 0.94 | TRUE |