TWAS hub - RPS6KA1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0412	0.0157	6.9e-05	0.013	0.027	0.028	0.028	0.025	0.0041	5.4e-05	4.1e-05	3.9e-05	8.7e-05
2	TCGA	Pheochromocytoma and Paraganglioma	0.1070	0.0550	1.9e-03	0.048	0.071	0.071	NA	0.072	0.0056	8.6e-04	8.7e-04	NA	8.0e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Forced expiratory volume in 1-second (FEV1)	11.9	40.0	53.3	5.2	7.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	11.0	23.2	30.9	5.6	3.9
Forced expiratory volume in 1-second (FEV1), Best measure	10.9	34.7	42.9	5.1	6.6
Forced vital capacity (FVC)	10.0	38.5	52.9	4.9	7.3
Forced vital capacity (FVC), Best measure	9.5	34.8	40.6	5.4	6.4
High cholesterol (Self-reported)	9.3	16.5	22.5	-4.7	-3.2
Peak expiratory flow (PEF)	8.3	19.2	27.8	3.2	5.3
Lung FVC	6.3	32.1	37.0	5.2	6.1
Mother’s age at death	5.8	7.3	7.7	2.6	2.8
Exposure to tobacco smoke at home	5.7	6.5	7.8	-2.8	-2.2
Diabetes diagnosed by doctor	5.4	8.9	13.8	-3.7	-2.0
Hearing difficulty/problems with background noise	5.3	8.4	13.3	-1.9	-3.6
Diabetes (self-reported)	5.1	7.9	13.0	-3.6	-1.7
Angina (self-reported)	5.1	6.7	9.1	-3.0	-2.1
Angina	5.0	6.6	9.1	-3.0	-2.0
Stomach or abdominal pain in last month	4.9	6.1	8.3	2.9	2.0
Sitting height	4.9	35.0	62.1	2.8	7.9
Medication: Ramipril	4.8	6.1	8.9	-3.0	-1.8
Medication: Cholesterol lowering	4.8	7.5	8.0	-2.8	-2.7
Financial situation satisfaction	4.8	5.9	10.6	-1.1	-3.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.7	5.5	7.3	-1.9	-2.7
Supplements: Vitamin C	4.6	5.5	9.4	3.1	1.3
Diabetes (mother)	4.2	5.3	9.6	-1.0	-3.1
Medication: Atorvastatin	4.2	5.2	9.7	-3.1	-0.8
Cholesterol lowering medication	4.2	6.2	10.0	-3.2	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	4.0	8.4	16.6	0.4	4.1
Trunk fat-free mass	3.8	21.6	29.7	3.7	5.5
Chronic bronchitis/emphysema (mother)	3.8	4.5	7.1	-2.7	-1.4
Hand grip strength (left)	3.7	9.8	13.0	2.6	3.6
Trunk predicted mass	3.7	21.4	30.0	3.6	5.5
Height	3.6	68.9	125.4	3.5	11.2
Standing height	3.6	35.3	64.5	2.5	8.0
Taking other prescription medications	3.5	5.4	10.8	0.3	-3.3
Medication: Levothyroxine sodium	3.5	5.9	11.7	-0.4	-3.4
Hand grip strength (right)	3.3	9.0	14.1	2.0	3.8
Medication: Simvastatin	3.3	4.9	6.4	-2.5	-1.9
Emphysema/chronic bronchitis	3.2	3.7	6.5	-0.9	-2.5
Type 2 Diabetes (T2D) (2018)	3.1	5.8	10.0	-3.2	-1.3
Medication for hormone replacement therapy	3.1	3.4	3.5	-1.9	-1.8
Pain all over the body in last month	3.1	3.3	6.6	-0.0	-2.6
Illnesses of siblings	3.1	4.4	8.5	-2.9	-0.6
Hypothyroidism/myxoedema (self-reported)	3.1	6.0	12.0	0.1	-3.5
Arm fat-free mass (right)	3.1	16.1	19.4	3.6	4.4
Arm predicted mass (right)	3.1	15.7	20.2	3.4	4.5
Whole body water mass	3.1	17.4	23.1	3.4	4.8
Whole body fat-free mass	3.0	17.2	22.3	3.5	4.7
Medication for cholesterol	3.0	4.6	5.0	2.0	2.2
Arm fat-free mass (left)	2.9	14.8	19.8	3.1	4.5
Alcohol drinker status: Previous	2.9	3.3	4.6	-2.1	-1.4
Mouth/teeth dental problems: Loose teeth	2.8	3.3	5.9	-0.9	-2.4
Comparative height size at age 10	2.8	15.5	28.7	1.5	5.4
Crohns Disease (2012)	2.7	4.3	7.5	-1.1	-2.7
Blood clot in the leg (DVT)	2.7	3.5	5.8	2.4	1.1
Medication: Atenolol	2.6	3.3	4.0	-2.0	-1.6
Noisy workplace	2.6	3.2	4.7	-1.3	-2.2
Number of self-reported non-cancer illnesses	2.6	4.6	8.4	-0.9	-2.9
Ever taken oral contraceptive pill	2.6	2.9	4.6	-2.1	1.1
Arm predicted mass (left)	2.6	13.4	19.3	2.8	4.4
Relative age voice broke	2.5	3.8	7.7	-0.1	2.8
Pulse rate, automated reading	2.5	8.1	16.1	-4.0	-0.3
Ulcerative Colitis	2.4	3.4	3.8	-1.9	-1.8
Hypothyroidism (self reported)	2.4	5.5	11.0	0.0	-3.3
Ever used hormone-replacement therapy (HRT)	2.4	3.1	4.3	-2.1	-1.4
Worry too long after embarrassment	2.4	4.1	4.5	1.9	2.1
Number of treatments/medications taken	2.3	4.1	7.8	-0.6	-2.8
Asthma	2.3	4.5	8.9	-0.3	-3.0
Ever highly irritable/argumentative for 2 days	2.3	2.8	4.7	-1.0	-2.2
Basal metabolic rate	2.3	12.5	16.0	3.0	4.0
Vitamin and mineral supplements	2.2	2.9	5.8	-2.4	-0.2
Had other major operations	2.2	2.7	4.1	-1.2	-2.0
Financial difficulties in last 2 years	2.2	3.0	3.6	-1.6	-1.9
Arm fat percentage (left)	2.2	8.9	16.7	-1.0	-4.1
Ever had prostate specific antigen (PSA) test	2.2	2.5	4.8	2.2	0.4
Hearing difficulty/problems: Yes	2.1	3.3	4.4	-2.1	-1.5
Medication: Metformin	2.1	3.0	5.2	-2.3	-0.9
Ever unenthusiastic/disinterested for a whole week	2.1	2.5	5.0	-0.3	-2.2
Overall health rating	2.1	4.6	9.1	0.1	-3.0
Illnesses of father: Heart disease	2.1	2.9	5.6	-0.5	-2.4
Leg fat-free mass (right)	2.1	11.0	12.9	3.0	3.6
Asthma (self-reported)	2.1	4.2	8.3	-0.2	-2.9
Leg predicted mass (right)	2.1	11.1	13.3	3.0	3.6
Ever depressed for a whole week	2.1	2.6	5.2	-0.4	-2.3
Type 2 Diabetes (T2D) (2012)	2.0	2.3	3.5	-1.1	-1.9
Cardiovascular Disease	2.0	6.6	8.8	-3.0	-2.1
Long-standing illness, disability or infirmity	2.0	3.0	5.8	-0.5	-2.4
Unable to work because of sickness or disability	2.0	2.6	5.0	0.5	-2.2
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	4.5	2.1	0.8
Depressed Affect (Nagel 2018)	1.9	4.0	5.1	-1.7	-2.3
Irritable Bowel Disease (IBD)	1.9	4.6	9.0	-0.5	-3.0
Supplements: Glucosamine	1.9	2.5	4.8	2.2	0.4
Allergy	1.9	4.3	8.3	0.6	2.9
Arm fat percentage (right)	1.9	7.7	13.9	-1.2	-3.7
Qualifications: A levels/AS levels or equivalent	1.9	4.3	8.0	0.8	2.8
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	3.3	1.8	1.7
Loneliness, isolation	1.9	2.6	4.6	-0.7	-2.1
Leg fat percentage (left)	1.9	7.0	13.4	-0.8	-3.7
LDL Cholesterol	1.8	2.9	4.5	-2.1	-1.1
Leg fat-free mass (left)	1.8	9.5	11.2	2.8	3.3
Leg predicted mass (left)	1.8	9.5	11.4	2.8	3.4
Heart attack	1.8	2.3	3.7	-1.9	-0.9
Body fat percentage	1.8	6.9	12.5	-1.1	-3.5
Leg fat percentage (right)	1.8	6.6	12.7	-0.8	-3.6
Medication: Gliclazide	1.8	2.0	3.8	-1.9	-0.6
Heart attack/myocardial infarction (self-reported)	1.8	2.3	4.0	-2.0	-0.8
Blood Red Count	1.7	16.3	23.7	-3.0	-4.9
Multivitamins +/- minerals	1.7	2.1	3.5	1.9	0.8
Mouth/teeth dental problems: Bleeding gums	1.7	2.1	2.2	-1.5	-1.5
Hearing aid user	1.7	1.9	3.6	-1.9	0.6
Intelligence (Savage-Jansen 2018)	1.6	5.0	9.5	-0.7	3.1
Major Depression (MDD)	1.6	1.9	3.7	0.3	-1.9
Blood White Count	1.6	11.7	15.3	2.9	-3.9
Lung FEV1/FVC ratio	1.6	8.4	13.9	1.7	3.7
Mouth/teeth dental problems	1.6	2.5	2.8	1.5	1.7
Knee pain experienced in last month	1.6	2.5	4.7	-0.6	-2.2
Mineral and other dietary supplements	1.6	2.1	4.2	-2.1	0.0
Crohns Disease (2017)	1.5	3.3	6.3	0.5	-2.5
Respiratory disease	1.5	3.3	6.2	-0.7	-2.5
Impedance of arm (right)	1.5	6.8	10.2	-3.2	-1.9
Pulse rate	1.5	2.6	5.1	-2.2	-0.2
Happiness	1.5	1.9	3.2	-0.7	-1.8
Gout (self-reported)	1.5	2.0	3.5	-0.8	-1.9
Exposure to tobacco smoke outside home	1.5	2.0	2.9	-1.7	-1.0
Ever had bowel cancer screening	1.5	1.8	2.7	0.9	1.6
Medication: Aspirin	1.5	1.9	3.1	-1.8	-0.8
HDL Cholesterol	1.4	2.3	3.4	1.8	-1.1
Average weekly spirits intake	1.4	1.8	2.6	1.6	1.0
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	2.1	1.4	-1.2
Age when periods started (menarche)	1.4	3.3	3.7	1.9	1.7
Loud music exposure frequency	1.4	1.6	2.4	-1.6	-0.8
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	3.6	0.9	1.9
Wheeze or whistling in the chest in last year	1.4	2.5	4.9	-0.3	-2.2
Osteoarthritis (self-reported)	1.4	1.8	2.5	-1.1	-1.6
Ovarian Cancer	1.3	1.7	2.3	-1.5	-1.1
Waist Hip Ratio (WHR)	1.3	6.0	12.0	-3.5	-0.1
Relative age of first facial hair	1.3	2.6	4.4	-0.9	2.1
Diabetes (father)	1.3	1.6	1.8	-1.2	-1.3
Fed-up feelings	1.3	2.4	3.8	-1.9	-1.1
Medication: Allopurinol	1.3	1.7	2.2	-1.1	-1.5
Had major operations	1.3	1.5	2.0	-1.4	-1.0
Tinnitus: Yes, now most or all of the time	1.3	1.6	2.2	1.5	0.9
Heart disease (siblings)	1.3	1.6	2.1	1.1	1.4
Verbal and Numeric Reasoning (VNR)	1.2	2.9	5.1	0.8	2.3
Trunk fat percentage	1.2	4.9	8.8	-1.0	-3.0
Impedance of arm (left)	1.2	5.8	6.8	-2.6	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.8	0.6	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.5	2.0	1.4	0.9
Medication: Blood pressure	1.2	2.1	2.8	-1.7	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	1.6	-1.0	1.3
Schizophrenia vs Biploar Disorder	1.1	1.4	2.8	1.7	-0.4
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	1.5	-0.9	-1.2
Number of incorrect matches in round	1.1	1.9	3.2	0.7	-1.8
Fluid intelligence score	1.1	2.3	4.6	-0.3	2.1
Prospective memory result	1.1	1.4	2.6	-0.3	-1.6
Hair/balding pattern: Pattern 4	1.1	2.6	3.6	-1.3	-1.9
Health satisfaction	1.1	1.4	2.5	0.6	-1.6
Supplements: Calcium	1.1	1.2	1.4	-1.2	-1.0
HbA1C	1.0	1.1	2.2	-0.3	-1.5
Triglycerides	1.0	1.6	2.1	-1.4	-1.0
Supplements: Zinc	1.0	1.1	2.1	-0.1	1.5
Medication: Co-codamol	1.0	1.1	1.6	1.3	-0.8
Maternal smoking around birth	1.0	1.5	2.5	-1.6	0.7
Had menopause	1.0	1.3	1.6	-1.0	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.6	-0.7	-1.6
Falls in the last year	1.0	1.4	1.5	-1.2	-1.2
Tense / ‘highly strung’	1.0	1.7	2.0	-1.4	-1.1
Birth weight	1.0	2.3	3.1	1.8	1.2
Comparative body size at age 10	1.0	2.8	3.3	1.5	1.8
Shortness of breath walking on level ground	1.0	1.2	1.3	-1.0	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.4	1.6	-0.3
Leg pain on walking	1.0	1.2	2.4	-0.2	-1.6
Medication: Aspirin	1.0	1.3	2.4	-1.5	-0.5
Illnesses of father: High blood pressure	1.0	1.3	1.7	-1.3	-0.9
Average weekly beer plus cider intake	1.0	1.4	2.4	-1.5	-0.7
Irritability	1.0	1.7	2.6	-1.6	-0.9
Commuting to job workplace: Cycle	1.0	1.2	1.9	-0.7	1.4
Vascular/heart problems diagnosed by doctor	1.0	2.8	3.9	1.3	2.0
Impedance of whole body	1.0	5.3	7.7	-2.8	-1.7
Coronary Artery Disease (CAD)	0.9	1.1	2.0	-1.4	0.4
Primary Biliary Cirrhosis	0.9	1.3	2.1	-0.7	-1.5
Blood Eosinophil Count	0.9	6.8	13.5	-3.7	-0.2
Severe depression (siblings)	0.9	1.0	1.7	0.5	1.3
Pack years adult smoking proportion	0.9	1.3	2.6	-0.3	1.6
Serious illness, injury or assault to yourself	0.9	1.1	2.2	-0.3	-1.5
Depression (self-reported)	0.9	1.1	2.2	-0.1	-1.5
Pulse wave Arterial Stiffness index	0.9	1.0	1.4	-0.8	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.7	0.3	-1.6
Pulse wave reflection index	0.9	1.2	2.2	-0.2	1.5
Age at first live birth	0.9	1.6	2.5	0.8	1.6
Number of full sisters	0.9	1.1	1.1	-1.1	-1.0
Commuting to job workplace: Walk	0.9	0.9	1.0	0.9	1.0
Osteoporosis (self-reported)	0.9	1.1	2.0	-0.5	-1.4
Illnesses of father: None of the above (group 1)	0.9	1.1	2.0	0.5	1.4
Pain experienced in last month	0.9	1.5	3.1	-1.7	0.1
Fasting Glucose	0.8	1.0	1.8	-0.4	-1.3
Allergy or Eczema	0.8	2.1	2.8	-1.2	-1.7
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.5	-0.8	-1.2
Neck or shoulder pain in last month	0.8	1.2	2.2	1.5	0.4
Suffer from ‘nerves’	0.8	1.3	1.7	-1.3	-1.0
Family relationship satisfaction	0.8	1.0	1.5	-1.2	-0.7
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.8	0.2	-1.3
Back pain experienced in last month	0.8	1.2	2.3	-0.0	-1.5
Wears glasses or contact lenses	0.8	1.0	1.7	1.3	0.4
Medication: Blood pressure	0.8	1.6	3.1	-0.3	-1.8
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.1	1.5	0.2
Pack years of smoking	0.8	1.2	2.0	-0.6	1.4
Impedance of leg (right)	0.7	3.6	5.4	-2.3	-1.3
Hayfever, allergic rhinitis or eczema	0.7	1.4	1.6	-1.1	-1.3
Impedance of leg (left)	0.7	3.3	4.9	-2.2	-1.3
Worrier / anxious feelings	0.7	1.3	2.7	1.6	-0.0
Headache pain in last month	0.7	1.1	2.2	0.2	1.5
Number of children fathered	0.7	0.8	0.9	0.9	0.9
Chest pain or discomfort	0.7	1.0	1.9	-1.4	0.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.2	-0.7	1.1
Mood swings	0.7	1.3	1.9	-0.8	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	1.8	0.7	-1.4
Myopia	0.7	1.0	1.6	0.6	-1.3
Bipolar Disorder (2018)	0.6	0.9	1.8	-1.3	0.2
Schizophrenia (2018)	0.6	1.3	1.3	1.1	-1.1
Alzheimer’s Disease (including proxy)	0.6	0.9	1.4	-0.6	-1.2
Breast Cancer	0.6	1.4	2.3	-1.5	-0.7
Body Mass Index (BMI) (2010)	0.6	0.9	1.7	1.3	-0.1
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.4	-0.5	-1.2
Average weekly fortified wine intake	0.6	0.7	1.4	1.2	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.8	-0.4	-1.7
High blood pressure	0.6	1.7	3.1	-0.6	-1.8
Body mass index (BMI)	0.6	2.7	5.3	0.2	-2.3
Alcohol usually taken with meals	0.6	1.0	1.6	1.2	0.7
Father’s age at death	0.6	0.9	1.4	0.5	1.2
Medication: Paracetamol	0.6	1.0	1.1	0.9	1.1
Medication: Bendroflumethiazide	0.6	1.0	1.7	-1.3	-0.5
Age started oral contraceptive pill	0.6	0.7	1.4	0.2	1.2
Ulcerative Colitis (UC)	0.5	1.0	1.4	-0.7	-1.2
Neuroticism (2016)	0.5	0.7	1.2	0.5	-1.1
BMI	0.5	2.7	5.3	0.3	-2.3
Past tobacco smoking	0.5	1.0	1.3	1.1	0.8
Pulse wave peak to peak time	0.5	0.6	1.0	1.0	-0.5
Alcohol intake frequency.	0.5	1.2	1.3	1.0	-1.1
Age at last live birth	0.5	0.7	1.0	1.0	0.6
Hypertension (Self-reported)	0.5	1.4	2.5	-0.6	-1.6
Medication: Paracetamol	0.5	0.7	0.8	0.8	0.9
Medication: Lisinopril	0.5	0.7	0.7	-0.9	-0.8
Neuroticism (Nagel 2018)	0.4	0.9	1.5	-0.6	-1.2
Worry (Nagel 2018)	0.4	0.8	1.3	-0.5	-1.1
Age at First Birth	0.4	0.6	0.8	0.9	0.7
Heel T-Score	0.4	3.3	4.2	-1.6	-2.0
Systolic Blood Pressure	0.4	2.2	2.4	-1.6	-1.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.6	0.8	0.7
High blood pressure (mother)	0.4	0.5	1.0	1.0	0.3
Waist circumference	0.4	1.5	1.7	-1.1	-1.3
Hair/balding pattern: Pattern 2	0.4	0.6	1.1	-1.0	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.7	0.5	-1.3
Weight	0.4	1.8	1.8	1.3	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	0.9	-0.2
Breastfed as a baby	0.4	0.4	0.9	0.9	-0.2
Medication: Ventolin 100micrograms inhaler	0.4	0.6	0.7	-0.6	-0.9
High blood pressure (siblings)	0.4	0.6	1.2	1.1	-0.1
Leg fat mass (right)	0.4	1.5	2.9	0.3	-1.7
Illnesses of siblings: Diabetes	0.4	0.4	0.8	0.3	-0.9
Qualifications: nursing, teaching	0.4	0.6	0.7	0.7	0.8
Arm fat mass (left)	0.4	1.7	3.4	0.1	-1.8
Diastolic blood pressure, automated reading	0.4	1.3	2.2	-1.5	-0.6
Leg fat mass (left)	0.4	1.5	3.0	0.2	-1.7
Depression (Nagel 2018)	0.3	0.4	0.5	-0.6	-0.7
Bipolar Disorder (2011)	0.3	0.3	0.5	-0.7	0.0
Lupus	0.3	0.4	0.6	-0.4	0.8
Schizophrenia (2014)	0.3	0.8	0.9	0.8	-0.9
Hair Pigment	0.3	7.7	14.0	-3.7	-1.2
Qualifications: CSEs or equivalent	0.3	0.3	0.7	0.8	0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.5	0.5	-0.7
Chronic bronchitis/emphysema (father)	0.3	0.3	0.6	-0.2	-0.8
Nervous feelings	0.3	0.6	0.9	0.6	-0.9
Alcohol intake versus 10 years previously	0.3	0.4	0.6	0.4	-0.8
Mouth/teeth dental problems: Dentures	0.3	0.5	0.7	-0.8	-0.6
Medication: Lansoprazole	0.3	0.3	0.7	0.1	-0.8
Arm fat mass (right)	0.3	1.3	2.6	0.1	-1.6
Qualifications: College or University degree	0.3	1.0	1.8	0.4	1.3
Eye problems/disorders: None of the above	0.3	0.4	0.4	0.6	0.6
Heart disease (mother)	0.3	0.3	0.7	-0.8	-0.0
Whole body fat mass	0.3	1.4	2.8	-0.1	-1.7
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	0.8	-0.0
Smoking status: Previous	0.3	0.5	0.7	-0.8	-0.4
Average weekly red wine intake	0.3	0.5	0.6	-0.5	0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.4	0.7	-0.6
Number of operations (self-reported)	0.3	0.5	0.5	-0.6	-0.7
Basal cell carcinoma (self-reported)	0.3	0.4	0.7	-0.8	0.3
Reaction Time	0.2	0.4	0.9	0.9	-0.1
Blood Platelet Count	0.2	2.3	2.8	1.7	-1.4
Neuroticism	0.2	0.5	0.9	-0.3	-0.9
Sensitivity / hurt feelings	0.2	0.3	0.6	-0.1	-0.8
Townsend deprivation index at recruitment	0.2	0.2	0.4	-0.6	0.3
Trunk fat mass	0.2	1.0	1.9	0.0	-1.4
Hair/balding pattern: Pattern 3	0.2	0.3	0.3	0.6	-0.5
Lung cancer (father)	0.2	0.2	0.4	0.3	-0.6
Illnesses of mother	0.2	0.2	0.3	0.5	0.4
Medication: Amlodipine	0.2	0.2	0.3	-0.6	-0.4
Medication: Ibuprofen	0.2	0.2	0.3	0.5	-0.3
Mean time to correctly identify matches	0.2	0.4	0.8	0.9	0.2
Breast cancer (self-reported)	0.2	0.3	0.4	0.3	-0.7
Average weekly champagne plus white wine intake	0.2	0.3	0.6	-0.8	-0.1
Miserableness	0.2	0.4	0.8	-0.3	0.9
Guilty feelings	0.2	0.3	0.3	0.5	0.6
Commuting to job workplace: Public transport	0.2	0.2	0.3	-0.6	-0.2
Ever smoked	0.2	0.3	0.5	-0.2	-0.7
Risk taking	0.2	0.3	0.6	-0.8	-0.1
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	0.1	-0.8
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	0.4	-0.2
Mean Putamen Volume	0.1	0.1	0.2	0.4	0.0
Smoking Status	0.1	0.2	0.3	-0.5	-0.3
Tanning	0.1	1.7	2.8	-1.7	-0.8
Current tobacco smoking	0.1	0.2	0.4	-0.1	-0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.5	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	-0.6	0.0
Qualifications: None of the above	0.1	0.2	0.4	-0.2	-0.6
Neuroticism score	0.1	0.2	0.3	-0.1	-0.5
Hip circumference	0.1	0.6	0.9	0.5	-1.0
Number of live births	0.1	0.2	0.2	-0.5	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.0	0.5
Length of working week for main job	0.1	0.1	0.2	0.2	0.5
Glaucoma (self-reported)	0.1	0.1	0.2	-0.4	-0.0
Number of full brothers	0.1	0.1	0.3	0.1	-0.5
Medication: Omeprazole	0.1	0.2	0.2	-0.3	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.4	-0.3
Friendships satisfaction	0.1	0.1	0.1	0.1	-0.4
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.3	-0.4
Smoking status: Current	0.1	0.2	0.3	-0.3	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.4	0.1
Alzheimer’s Disease (in father)	0.0	0.0	0.0	-0.2	-0.0
Prostate Cancer	0.0	0.1	0.1	-0.3	0.2
Rheumatoid Arthritis	0.0	0.1	0.1	-0.3	-0.0
Chronotype (morning person)	0.0	0.1	0.2	-0.5	-0.1
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	-0.0	-0.3
Systolic blood pressure, automated reading	0.0	0.1	0.1	0.0	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	0.2	-0.0
Time employed in main current job	0.0	0.1	0.1	-0.2	-0.3
Birth weight of first child	0.0	0.1	0.1	-0.1	0.4
Medication for pain relief, constipation, heartburn	0.0	0.0	0.0	-0.2	-0.2
Migraine (self-reported)	0.0	0.0	0.1	0.2	0.0
Medication: Seretide 50 evohaler	0.0	0.0	0.0	0.1	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.1	0.1	-0.3
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	-0.3	-0.0
Alcohol drinker status: Never	0.0	0.0	0.0	-0.2	0.1
Fractured/broken bones in last 5 years	0.0	0.0	0.0	0.0	-0.2

Hub : Genes

RPS6KA1

Models

Trait associations