Best TWAS P=7.44e-15 · Best GWAS P=1.99e-14 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | KHNYN | 0.30 | 0.14 | lasso | 2 | 0.14 | 7.1e-12 | 5.1 | 5.4 | 8.4e-08 | 0.09 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | ADCY4 | 0.08 | 0.04 | lasso | 3 | 0.03 | 3.3e-03 | 5.1 | 5.4 | 5.6e-08 | 0.62 | 0.20 | 0.27 | FALSE |
3 | GTEx | Adipose Subcutaneous | CBLN3 | 0.65 | 0.39 | lasso | 23 | 0.37 | 6.1e-32 | 5.1 | -5.1 | 2.9e-07 | -0.10 | 1.00 | 0.00 | FALSE |
4 | GTEx | Adipose Subcutaneous | LTB4R | 0.14 | 0.12 | lasso | 3 | 0.12 | 1.3e-09 | 5.1 | -5.2 | 2.4e-07 | -0.61 | 0.92 | 0.08 | FALSE |
5 | GTEx | Breast Mammary Tissue | LTB4R | 0.30 | 0.18 | lasso | 4 | 0.16 | 2.3e-08 | 5.3 | -5.3 | 1.2e-07 | -0.63 | 0.78 | 0.21 | TRUE |
6 | GTEx | Breast Mammary Tissue (Female) | CBLN3 | 0.42 | 0.20 | lasso | 4 | 0.28 | 5.9e-09 | 5.1 | -5.2 | 1.8e-07 | -0.08 | 0.84 | 0.02 | FALSE |
7 | GTEx | Heart Atrial Appendage | ADCY4 | 0.28 | 0.14 | lasso | 4 | 0.10 | 2.1e-05 | 7.1 | 6.1 | 9.5e-10 | 0.48 | 0.09 | 0.80 | FALSE |
8 | GTEx | Heart Atrial Appendage | CBLN3 | 0.58 | 0.40 | lasso | 5 | 0.38 | 2.3e-18 | 5.1 | -5.1 | 2.9e-07 | -0.11 | 1.00 | 0.00 | FALSE |
9 | GTEx | Heart Left Ventricle | CBLN3 | 0.35 | 0.23 | lasso | 8 | 0.21 | 1.5e-11 | 5.1 | -5.5 | 4.6e-08 | -0.16 | 1.00 | 0.00 | TRUE |
10 | GTEx | Lung | KHNYN | 0.14 | 0.08 | lasso | 5 | 0.05 | 9.7e-05 | 4.7 | 5.2 | 2.2e-07 | 0.08 | 0.66 | 0.01 | FALSE |
11 | GTEx | Lung | LTB4R | 0.19 | 0.15 | lasso | 6 | 0.12 | 2.0e-09 | 5.1 | -5.6 | 1.9e-08 | -0.66 | 0.99 | 0.01 | FALSE |
12 | GTEx | Muscle Skeletal | CBLN3 | 0.14 | 0.13 | enet | 7 | 0.13 | 4.8e-13 | 5.1 | -5.7 | 1.5e-08 | -0.13 | 1.00 | 0.00 | FALSE |
13 | GTEx | Nerve Tibial | KHNYN | 0.34 | 0.10 | lasso | 8 | 0.15 | 1.6e-10 | 4.7 | 5.3 | 9.9e-08 | 0.10 | 1.00 | 0.00 | TRUE |
14 | GTEx | Ovary | CBLN3 | 0.62 | 0.38 | lasso | 19 | 0.39 | 1.2e-10 | 5.1 | -5.2 | 2.1e-07 | -0.10 | 0.96 | 0.00 | FALSE |
15 | GTEx | Spleen | NFATC4 | 0.45 | 0.00 | enet | 24 | 0.00 | 2.5e-01 | 5.1 | -6.3 | 3.5e-10 | -0.22 | 0.07 | 0.06 | TRUE |
16 | GTEx | Thyroid | ADCY4 | 0.13 | 0.13 | lasso | 6 | 0.09 | 1.0e-07 | 4.2 | 5.6 | 1.8e-08 | 0.51 | 0.36 | 0.64 | FALSE |
17 | METSIM | Adipose | ADCY4 | 0.07 | 0.03 | lasso | 5 | 0.03 | 2.2e-05 | 7.3 | 7.8 | 7.4e-15 | 0.71 | 0.04 | 0.96 | TRUE |
18 | METSIM | Adipose | RABGGTA | 0.10 | 0.06 | lasso | 9 | 0.08 | 5.5e-12 | 5.7 | 5.3 | 9.3e-08 | 0.62 | 0.99 | 0.01 | FALSE |
19 | YFS | Blood | KHNYN | 0.36 | 0.20 | enet | 50 | 0.29 | 1.2e-96 | 4.5 | 5.4 | 5.8e-08 | 0.14 | 1.00 | 0.00 | FALSE |
20 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ADCY4 | 0.03 | 0.01 | blup | 75 | 0.03 | 1.1e-03 | 4.8 | 6.0 | 2.3e-09 | 0.71 | 0.05 | 0.72 | FALSE |
21 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CBLN3 | 0.34 | 0.15 | lasso | 5 | 0.14 | 2.4e-07 | 5.1 | -5.3 | 1.1e-07 | -0.17 | 0.34 | 0.63 | FALSE |
22 | The Cancer Genome Atlas | Colon Adenocarcinoma | ADCY4 | 0.07 | 0.02 | lasso | 4 | 0.03 | 4.7e-03 | 4.9 | 5.8 | 5.4e-09 | 0.70 | 0.03 | 0.76 | TRUE |
23 | The Cancer Genome Atlas | Colon Adenocarcinoma | CBLN3 | 0.24 | 0.14 | enet | 8 | 0.13 | 4.0e-08 | 5.1 | -5.5 | 3.3e-08 | -0.14 | 0.35 | 0.65 | FALSE |
24 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADCY4 | 0.06 | 0.06 | lasso | 6 | 0.09 | 3.0e-10 | 6.5 | 7.5 | 6.0e-14 | 0.75 | 0.06 | 0.94 | FALSE |
25 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADCY4 | 0.07 | 0.09 | lasso | 3 | 0.08 | 4.4e-10 | 5.3 | 6.6 | 4.8e-11 | 0.73 | 0.88 | 0.12 | FALSE |
26 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LTB4R | 0.16 | 0.05 | blup | 73 | 0.08 | 4.9e-04 | 3.6 | -5.7 | 1.6e-08 | -0.70 | 0.03 | 0.56 | FALSE |
27 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CBLN3 | 0.30 | 0.26 | lasso | 1 | 0.24 | 1.4e-17 | 5.1 | -5.1 | 2.9e-07 | -0.11 | 0.34 | 0.66 | FALSE |
28 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LTB4R | 0.04 | 0.01 | blup | 73 | 0.01 | 4.2e-02 | 6.1 | -5.9 | 3.8e-09 | -0.63 | 0.01 | 0.46 | FALSE |
29 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LTB4R2 | 0.04 | 0.04 | lasso | 1 | 0.02 | 2.5e-02 | 6.1 | -6.1 | 9.9e-10 | -0.70 | 0.04 | 0.52 | FALSE |
30 | The Cancer Genome Atlas | Thyroid Carcinoma | LTB4R | 0.08 | 0.05 | lasso | 8 | 0.05 | 1.7e-05 | 4.8 | -5.2 | 2.1e-07 | -0.58 | 0.63 | 0.16 | FALSE |