Best TWAS P=7.19e-13 · Best GWAS P=3.5e-10 conditioned to 0.366
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PPP2R3C | 0.21 | 0.12 | lasso | 10 | 0.14 | 2.6e-11 | -6.3 | 5.6 | 1.7e-08 | -0.95 | 0.00 | 1.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | FAM177A1 | 0.19 | 0.06 | lasso | 8 | 0.11 | 3.6e-09 | 2.7 | 5.4 | 8.4e-08 | -0.67 | 0.04 | 0.96 | FALSE |
3 | GTEx | Artery Tibial | RP11-85K15.2 | 0.06 | 0.01 | lasso | 6 | 0.02 | 2.1e-02 | -5.8 | -5.8 | 6.9e-09 | 0.67 | 0.05 | 0.75 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | PPP2R3C | 0.31 | 0.10 | lasso | 10 | 0.18 | 4.0e-13 | -6.3 | 5.9 | 4.5e-09 | -0.87 | 0.00 | 1.00 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | CFL2 | 0.14 | 0.08 | enet | 39 | 0.11 | 9.9e-09 | -3.2 | -7.2 | 7.2e-13 | 0.30 | 0.59 | 0.04 | TRUE |
6 | GTEx | Skin Sun Exposed Lower leg | FAM177A1 | 0.19 | 0.04 | lasso | 10 | 0.10 | 1.7e-08 | -4.6 | 5.2 | 2.2e-07 | -0.72 | 0.01 | 0.99 | FALSE |
7 | NTR | Blood | NFKBIA | 0.26 | 0.09 | lasso | 10 | 0.12 | 3.4e-36 | -4.7 | -6.6 | 3.6e-11 | 0.42 | 0.89 | 0.11 | FALSE |
8 | NTR | Blood | PPP2R3C | 0.06 | 0.04 | lasso | 5 | 0.04 | 4.2e-14 | 4.5 | -5.3 | 9.0e-08 | 0.37 | 0.96 | 0.04 | FALSE |
9 | YFS | Blood | KIAA0391 | 0.29 | 0.36 | lasso | 7 | 0.38 | 5.8e-132 | -6.3 | -6.0 | 1.5e-09 | 0.99 | 0.00 | 1.00 | FALSE |
10 | YFS | Blood | NFKBIA | 0.24 | 0.11 | enet | 33 | 0.17 | 3.5e-53 | -4.6 | -6.7 | 3.0e-11 | 0.51 | 0.91 | 0.09 | TRUE |
11 | YFS | Blood | PPP2R3C | 0.53 | 0.46 | bslmm | 383 | 0.60 | 2.4e-254 | 4.4 | -6.2 | 6.8e-10 | 0.63 | 0.96 | 0.04 | FALSE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KIAA0391 | 0.07 | 0.04 | blup | 110 | 0.04 | 1.9e-05 | -3.5 | 5.6 | 1.8e-08 | -0.83 | 0.03 | 0.97 | FALSE |
13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PPP2R3C | 0.08 | 0.04 | blup | 51 | 0.07 | 7.8e-09 | -5.0 | 6.1 | 8.5e-10 | -0.82 | 0.01 | 0.99 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA0391 | 0.12 | 0.11 | enet | 14 | 0.14 | 2.0e-13 | -4.1 | 5.7 | 1.0e-08 | -0.77 | 0.70 | 0.30 | FALSE |