Best TWAS P=5.96e-23 · Best GWAS P=2.71e-23 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PEF1 | 0.04 | 0.04 | lasso | 4 | 0.03 | 2.8e-04 | -6.6 | 6.6 | 4.3e-11 | -0.01 | 0.09 | 0.90 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | PHC2 | 0.12 | 0.09 | bslmm | 500 | 0.12 | 4.7e-14 | 3.6 | 5.3 | 1.5e-07 | -0.58 | 1.00 | 0.00 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | TMEM54 | 0.05 | 0.00 | blup | 281 | 0.02 | 4.5e-03 | 2.6 | -8.8 | 1.8e-18 | 0.50 | 0.11 | 0.23 | FALSE |
4 | CommonMind | Brain Pre-frontal Cortex | ZNF362 | 0.05 | 0.06 | lasso | 1 | 0.06 | 2.2e-07 | -9.9 | -9.9 | 6.0e-23 | 0.98 | 0.01 | 0.99 | TRUE |
5 | GTEx | Artery Aorta | PEF1 | 0.15 | 0.05 | lasso | 5 | 0.04 | 2.2e-03 | -6.9 | 7.8 | 8.4e-15 | -0.05 | 0.04 | 0.92 | TRUE |
6 | GTEx | Artery Tibial | PEF1 | 0.10 | 0.09 | enet | 16 | 0.09 | 9.0e-08 | -6.6 | 5.6 | 1.9e-08 | -0.04 | 0.12 | 0.88 | FALSE |
7 | GTEx | Brain Cerebellum | RP11-415J8.3 | 0.25 | 0.06 | lasso | 3 | 0.07 | 4.2e-03 | 5.1 | -5.2 | 1.9e-07 | 0.53 | 0.14 | 0.06 | FALSE |
8 | GTEx | Cells EBV-transformed lymphocytes | KPNA6 | 0.19 | 0.14 | enet | 18 | 0.10 | 4.9e-04 | 5.7 | 6.3 | 3.3e-10 | -0.03 | 0.21 | 0.06 | FALSE |
9 | GTEx | Cells EBV-transformed lymphocytes | PHC2 | 0.58 | 0.34 | lasso | 7 | 0.28 | 7.3e-10 | -9.8 | 9.5 | 1.8e-21 | -0.99 | 0.01 | 0.99 | FALSE |
10 | GTEx | Cells Transformed fibroblasts | KPNA6 | 0.13 | 0.10 | lasso | 5 | 0.11 | 1.3e-08 | 5.8 | 5.8 | 8.3e-09 | -0.03 | 0.97 | 0.03 | FALSE |
11 | GTEx | Colon Sigmoid | PEF1 | 0.16 | 0.09 | lasso | 3 | 0.09 | 4.3e-04 | -6.9 | 7.3 | 3.2e-13 | -0.04 | 0.04 | 0.80 | FALSE |
12 | GTEx | Heart Atrial Appendage | RN7SKP16 | 0.08 | 0.06 | enet | 11 | 0.03 | 1.9e-02 | 3.8 | -6.0 | 1.7e-09 | 0.56 | 0.15 | 0.46 | FALSE |
13 | GTEx | Muscle Skeletal | ZNF362 | 0.04 | 0.01 | enet | 7 | 0.02 | 4.9e-03 | 4.1 | -6.2 | 4.1e-10 | 0.68 | 0.07 | 0.78 | FALSE |
14 | GTEx | Muscle Skeletal | FNDC5 | 0.15 | 0.16 | enet | 5 | 0.16 | 1.9e-15 | -5.1 | -5.2 | 2.1e-07 | 0.06 | 1.00 | 0.00 | FALSE |
15 | GTEx | Skin Not Sun Exposed Suprapubic | EIF3I | 0.12 | 0.06 | lasso | 1 | 0.03 | 7.2e-03 | 5.8 | -5.8 | 8.1e-09 | 0.03 | 0.09 | 0.04 | FALSE |
16 | GTEx | Skin Sun Exposed Lower leg | PEF1 | 0.05 | 0.03 | enet | 9 | 0.02 | 4.6e-03 | -6.9 | 6.1 | 1.1e-09 | -0.06 | 0.04 | 0.94 | FALSE |
17 | GTEx | Testis | RP4-622L5.7 | 0.12 | 0.11 | lasso | 5 | 0.08 | 2.3e-04 | 5.8 | 5.8 | 7.0e-09 | -0.03 | 0.35 | 0.13 | FALSE |
18 | METSIM | Adipose | KPNA6 | 0.07 | 0.06 | lasso | 10 | 0.06 | 1.8e-09 | 5.8 | 6.0 | 1.7e-09 | -0.03 | 0.97 | 0.03 | FALSE |
19 | METSIM | Adipose | PEF1 | 0.03 | 0.02 | enet | 17 | 0.02 | 7.9e-04 | -6.7 | 6.5 | 6.2e-11 | -0.02 | 0.05 | 0.88 | FALSE |
20 | METSIM | Adipose | ZNF362 | 0.09 | 0.02 | enet | 32 | 0.03 | 1.5e-05 | -9.9 | -6.7 | 2.1e-11 | 0.70 | 0.01 | 0.98 | FALSE |
21 | ROSMAP | Brain Pre-frontal Cortex | KPNA6 | 0.03 | 0.04 | lasso | 4 | 0.02 | 8.1e-04 | 5.8 | 6.0 | 2.5e-09 | -0.02 | 0.64 | 0.16 | FALSE |
22 | ROSMAP | Brain Pre-frontal Cortex | PHC2 | 0.11 | 0.07 | lasso | 3 | 0.05 | 2.2e-07 | -9.8 | -9.3 | 1.4e-20 | 0.99 | 0.01 | 0.99 | FALSE |
23 | ROSMAP | Brain Pre-frontal Cortex | PEF1 | 0.04 | 0.04 | lasso | 3 | 0.02 | 4.2e-04 | -6.7 | 6.6 | 5.2e-11 | -0.01 | 0.08 | 0.91 | FALSE |
24 | YFS | Blood | KPNA6 | 0.03 | 0.03 | bslmm | 236 | 0.04 | 1.1e-11 | 5.8 | 6.2 | 4.7e-10 | 0.01 | 0.97 | 0.03 | FALSE |
25 | The Cancer Genome Atlas | Breast Invasive Carcinoma | S100PBP | 0.03 | 0.02 | blup | 46 | 0.02 | 6.6e-06 | -5.7 | 5.6 | 2.5e-08 | -0.07 | 0.01 | 0.99 | FALSE |
26 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZNF362 | 0.03 | 0.01 | blup | 49 | 0.01 | 1.3e-03 | 3.8 | -7.4 | 1.7e-13 | 0.72 | 0.01 | 0.32 | FALSE |
27 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | S100PBP | 0.06 | 0.03 | blup | 48 | 0.06 | 6.8e-04 | -5.0 | 6.3 | 3.9e-10 | -0.06 | 0.01 | 0.82 | TRUE |
28 | The Cancer Genome Atlas | Glioblastoma Multiforme | S100PBP | 0.21 | 0.15 | lasso | 5 | 0.15 | 2.9e-05 | -5.1 | 5.1 | 2.9e-07 | -0.06 | 0.01 | 0.91 | FALSE |
29 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | S100PBP | 0.04 | 0.04 | lasso | 4 | 0.04 | 2.3e-05 | -5.6 | 5.6 | 1.7e-08 | -0.08 | 0.00 | 0.99 | FALSE |
30 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MTMR9L | 0.03 | 0.03 | blup | 28 | 0.01 | 1.6e-02 | 3.2 | 5.2 | 2.2e-07 | -0.02 | 0.03 | 0.58 | FALSE |
31 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KPNA6 | 0.02 | 0.02 | blup | 29 | 0.02 | 1.9e-03 | 5.7 | 5.7 | 1.5e-08 | -0.02 | 0.02 | 0.86 | FALSE |
32 | The Cancer Genome Atlas | Brain Lower Grade Glioma | S100PBP | 0.06 | 0.06 | blup | 47 | 0.05 | 5.2e-06 | -5.6 | 5.6 | 2.7e-08 | -0.07 | 0.00 | 1.00 | FALSE |
33 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | MTMR9L | 0.15 | 0.02 | blup | 29 | 0.09 | 2.8e-03 | 3.3 | 5.3 | 9.3e-08 | 0.01 | 0.01 | 0.38 | FALSE |
34 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PTP4A2 | 0.09 | -0.01 | blup | 26 | 0.00 | 4.1e-01 | 6.3 | 7.7 | 1.6e-14 | 0.00 | 0.01 | 0.49 | TRUE |
35 | The Cancer Genome Atlas | Thyroid Carcinoma | KPNA6 | 0.03 | 0.03 | blup | 28 | 0.03 | 5.3e-04 | 5.8 | 5.5 | 3.5e-08 | -0.02 | 0.02 | 0.89 | FALSE |