Best TWAS P=7.72e-18 · Best GWAS P=8.35e-16 conditioned to 0.00389
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | BBS7 | 0.19 | 0.21 | bslmm | 423 | 0.23 | 1.8e-27 | -7.75 | -7.9 | 2.5e-15 | -0.01 | 0.00 | 1.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | NUDT6 | 0.04 | 0.04 | lasso | 3 | 0.02 | 6.5e-04 | 5.90 | 6.0 | 2.6e-09 | 0.74 | 0.72 | 0.03 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | TMEM155 | 0.06 | 0.05 | lasso | 3 | 0.02 | 5.5e-04 | -6.65 | -6.2 | 4.0e-10 | -0.05 | 0.12 | 0.82 | FALSE |
4 | GTEx | Adipose Subcutaneous | EXOSC9 | 0.07 | 0.00 | lasso | 2 | 0.00 | 4.5e-01 | -6.00 | 5.8 | 8.5e-09 | 0.04 | 0.05 | 0.34 | FALSE |
5 | GTEx | Artery Tibial | FGF2 | 0.18 | 0.05 | lasso | 3 | 0.02 | 1.3e-02 | 6.78 | 7.0 | 3.0e-12 | 0.36 | 0.08 | 0.11 | TRUE |
6 | GTEx | Artery Tibial | NUDT6 | 0.08 | 0.08 | lasso | 5 | 0.05 | 5.6e-05 | 5.78 | 6.0 | 2.7e-09 | 0.73 | 0.65 | 0.08 | FALSE |
7 | GTEx | Brain Cerebellar Hemisphere | BBS7 | 0.27 | 0.05 | lasso | 3 | 0.08 | 4.7e-03 | -5.99 | -5.4 | 6.1e-08 | -0.01 | 0.08 | 0.34 | FALSE |
8 | GTEx | Brain Cerebellum | BBS7 | 0.20 | -0.01 | enet | 24 | 0.01 | 2.2e-01 | -5.93 | -6.0 | 1.9e-09 | -0.03 | 0.07 | 0.73 | FALSE |
9 | GTEx | Breast Mammary Tissue | NUDT6 | 0.25 | 0.10 | lasso | 3 | 0.08 | 4.2e-05 | 6.30 | 6.3 | 2.8e-10 | 0.83 | 0.12 | 0.83 | FALSE |
10 | GTEx | Breast Mammary Tissue (Male) | NUDT6 | 0.29 | 0.00 | lasso | 6 | 0.00 | 3.5e-01 | 5.62 | 6.1 | 1.2e-09 | 0.74 | 0.04 | 0.38 | FALSE |
11 | GTEx | Breast Mammary Tissue (Female) | NUDT6 | 0.30 | -0.01 | enet | 30 | 0.00 | 2.6e-01 | 6.53 | 5.9 | 4.2e-09 | 0.62 | 0.03 | 0.33 | FALSE |
12 | GTEx | Cells EBV-transformed lymphocytes | EXOSC9 | 0.29 | 0.17 | lasso | 7 | 0.16 | 6.6e-06 | 7.13 | 7.7 | 1.2e-14 | 0.01 | 0.15 | 0.83 | FALSE |
13 | GTEx | Cells Transformed fibroblasts | BBS7 | 0.16 | 0.09 | lasso | 7 | 0.16 | 2.9e-12 | -7.76 | -8.3 | 7.1e-17 | -0.03 | 0.00 | 1.00 | FALSE |
14 | GTEx | Colon Transverse | BBS12 | 0.12 | 0.05 | enet | 29 | 0.12 | 3.2e-06 | 0.43 | 6.3 | 2.2e-10 | 0.48 | 0.04 | 0.59 | TRUE |
15 | GTEx | Muscle Skeletal | NUDT6 | 0.15 | 0.12 | lasso | 3 | 0.11 | 1.1e-10 | 5.90 | 5.9 | 2.9e-09 | 0.74 | 1.00 | 0.00 | FALSE |
16 | GTEx | Muscle Skeletal | RP11-170N16.3 | 0.07 | 0.07 | lasso | 3 | 0.06 | 8.8e-07 | 4.87 | 5.8 | 9.1e-09 | 0.74 | 0.21 | 0.78 | FALSE |
17 | GTEx | Nerve Tibial | NUDT6 | 0.11 | 0.08 | lasso | 3 | 0.05 | 2.1e-04 | 5.42 | 5.4 | 5.5e-08 | 0.69 | 0.80 | 0.02 | FALSE |
18 | GTEx | Skin Not Sun Exposed Suprapubic | NUDT6 | 0.07 | 0.02 | lasso | 6 | 0.03 | 1.5e-02 | 4.73 | 5.7 | 1.2e-08 | 0.71 | 0.19 | 0.60 | FALSE |
19 | GTEx | Skin Sun Exposed Lower leg | NUDT6 | 0.11 | 0.08 | lasso | 3 | 0.08 | 6.2e-07 | 5.62 | 5.7 | 1.4e-08 | 0.70 | 0.95 | 0.02 | FALSE |
20 | GTEx | Testis | EXOSC9 | 0.17 | 0.07 | lasso | 8 | 0.10 | 2.5e-05 | -6.01 | 7.7 | 1.0e-14 | 0.04 | 0.01 | 0.98 | FALSE |
21 | ROSMAP | Brain Pre-frontal Cortex | EXOSC9 | 0.05 | 0.02 | lasso | 7 | 0.02 | 5.3e-04 | 5.29 | 5.9 | 3.9e-09 | -0.03 | 0.39 | 0.35 | FALSE |
22 | YFS | Blood | EXOSC9 | 0.06 | 0.09 | bslmm | 401 | 0.09 | 7.0e-28 | 7.24 | 7.6 | 2.6e-14 | 0.00 | 0.16 | 0.84 | FALSE |
23 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EXOSC9 | 0.03 | 0.04 | enet | 9 | 0.04 | 2.8e-08 | 7.18 | 8.0 | 1.1e-15 | 0.02 | 0.18 | 0.82 | FALSE |
24 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NUDT6 | 0.02 | 0.02 | lasso | 4 | 0.01 | 5.4e-03 | 5.77 | 5.7 | 9.6e-09 | 0.72 | 0.13 | 0.14 | FALSE |
25 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CCNA2 | 0.11 | -0.01 | enet | 14 | 0.02 | 4.4e-02 | 0.93 | 5.4 | 7.6e-08 | 0.09 | 0.00 | 0.27 | FALSE |
26 | The Cancer Genome Atlas | Colon Adenocarcinoma | BBS7 | 0.05 | 0.00 | blup | 47 | 0.02 | 1.9e-02 | 7.20 | -7.2 | 6.7e-13 | -0.03 | 0.02 | 0.16 | FALSE |
27 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BBS7 | 0.04 | 0.02 | blup | 47 | 0.03 | 1.3e-04 | -5.99 | -6.0 | 2.6e-09 | -0.03 | 0.05 | 0.91 | FALSE |
28 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CCNA2 | 0.03 | 0.01 | blup | 34 | 0.02 | 1.5e-03 | -7.71 | 8.6 | 7.7e-18 | 0.02 | 0.00 | 0.97 | TRUE |
29 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | BBS7 | 0.04 | 0.04 | lasso | 2 | 0.03 | 6.1e-04 | -7.75 | -7.8 | 9.4e-15 | -0.03 | 0.00 | 1.00 | FALSE |
30 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FGF2 | 0.06 | 0.04 | blup | 65 | 0.05 | 4.4e-06 | 7.09 | 6.8 | 1.5e-11 | 0.85 | 0.01 | 0.99 | FALSE |
31 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | EXOSC9 | 0.03 | 0.02 | lasso | 2 | 0.02 | 1.0e-03 | 7.38 | 7.9 | 2.3e-15 | 0.01 | 0.06 | 0.50 | FALSE |
32 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NUDT6 | 0.10 | 0.07 | lasso | 6 | 0.07 | 1.0e-07 | 5.78 | 5.4 | 6.1e-08 | 0.71 | 0.97 | 0.02 | FALSE |
33 | The Cancer Genome Atlas | Thyroid Carcinoma | EXOSC9 | 0.04 | 0.05 | lasso | 2 | 0.04 | 7.1e-05 | 7.18 | 8.1 | 4.7e-16 | 0.03 | 0.03 | 0.95 | FALSE |