[Hub]/) : Traits : Trunk predicted mass :

chr4:121,982,122-124,538,705

Best TWAS P=7.72e-18 · Best GWAS P=8.35e-16 conditioned to 0.00389

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex BBS7 0.19 0.21 bslmm 423 0.23 1.8e-27 -7.75 -7.9 2.5e-15 -0.01 0.00 1.00 FALSE
2 CommonMind Brain Pre-frontal Cortex NUDT6 0.04 0.04 lasso 3 0.02 6.5e-04 5.90 6.0 2.6e-09 0.74 0.72 0.03 FALSE
3 CommonMind Brain Pre-frontal Cortex TMEM155 0.06 0.05 lasso 3 0.02 5.5e-04 -6.65 -6.2 4.0e-10 -0.05 0.12 0.82 FALSE
4 GTEx Adipose Subcutaneous EXOSC9 0.07 0.00 lasso 2 0.00 4.5e-01 -6.00 5.8 8.5e-09 0.04 0.05 0.34 FALSE
5 GTEx Artery Tibial FGF2 0.18 0.05 lasso 3 0.02 1.3e-02 6.78 7.0 3.0e-12 0.36 0.08 0.11 TRUE
6 GTEx Artery Tibial NUDT6 0.08 0.08 lasso 5 0.05 5.6e-05 5.78 6.0 2.7e-09 0.73 0.65 0.08 FALSE
7 GTEx Brain Cerebellar Hemisphere BBS7 0.27 0.05 lasso 3 0.08 4.7e-03 -5.99 -5.4 6.1e-08 -0.01 0.08 0.34 FALSE
8 GTEx Brain Cerebellum BBS7 0.20 -0.01 enet 24 0.01 2.2e-01 -5.93 -6.0 1.9e-09 -0.03 0.07 0.73 FALSE
9 GTEx Breast Mammary Tissue NUDT6 0.25 0.10 lasso 3 0.08 4.2e-05 6.30 6.3 2.8e-10 0.83 0.12 0.83 FALSE
10 GTEx Breast Mammary Tissue (Male) NUDT6 0.29 0.00 lasso 6 0.00 3.5e-01 5.62 6.1 1.2e-09 0.74 0.04 0.38 FALSE
11 GTEx Breast Mammary Tissue (Female) NUDT6 0.30 -0.01 enet 30 0.00 2.6e-01 6.53 5.9 4.2e-09 0.62 0.03 0.33 FALSE
12 GTEx Cells EBV-transformed lymphocytes EXOSC9 0.29 0.17 lasso 7 0.16 6.6e-06 7.13 7.7 1.2e-14 0.01 0.15 0.83 FALSE
13 GTEx Cells Transformed fibroblasts BBS7 0.16 0.09 lasso 7 0.16 2.9e-12 -7.76 -8.3 7.1e-17 -0.03 0.00 1.00 FALSE
14 GTEx Colon Transverse BBS12 0.12 0.05 enet 29 0.12 3.2e-06 0.43 6.3 2.2e-10 0.48 0.04 0.59 TRUE
15 GTEx Muscle Skeletal NUDT6 0.15 0.12 lasso 3 0.11 1.1e-10 5.90 5.9 2.9e-09 0.74 1.00 0.00 FALSE
16 GTEx Muscle Skeletal RP11-170N16.3 0.07 0.07 lasso 3 0.06 8.8e-07 4.87 5.8 9.1e-09 0.74 0.21 0.78 FALSE
17 GTEx Nerve Tibial NUDT6 0.11 0.08 lasso 3 0.05 2.1e-04 5.42 5.4 5.5e-08 0.69 0.80 0.02 FALSE
18 GTEx Skin Not Sun Exposed Suprapubic NUDT6 0.07 0.02 lasso 6 0.03 1.5e-02 4.73 5.7 1.2e-08 0.71 0.19 0.60 FALSE
19 GTEx Skin Sun Exposed Lower leg NUDT6 0.11 0.08 lasso 3 0.08 6.2e-07 5.62 5.7 1.4e-08 0.70 0.95 0.02 FALSE
20 GTEx Testis EXOSC9 0.17 0.07 lasso 8 0.10 2.5e-05 -6.01 7.7 1.0e-14 0.04 0.01 0.98 FALSE
21 ROSMAP Brain Pre-frontal Cortex EXOSC9 0.05 0.02 lasso 7 0.02 5.3e-04 5.29 5.9 3.9e-09 -0.03 0.39 0.35 FALSE
22 YFS Blood EXOSC9 0.06 0.09 bslmm 401 0.09 7.0e-28 7.24 7.6 2.6e-14 0.00 0.16 0.84 FALSE
23 The Cancer Genome Atlas Breast Invasive Carcinoma EXOSC9 0.03 0.04 enet 9 0.04 2.8e-08 7.18 8.0 1.1e-15 0.02 0.18 0.82 FALSE
24 The Cancer Genome Atlas Breast Invasive Carcinoma NUDT6 0.02 0.02 lasso 4 0.01 5.4e-03 5.77 5.7 9.6e-09 0.72 0.13 0.14 FALSE
25 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CCNA2 0.11 -0.01 enet 14 0.02 4.4e-02 0.93 5.4 7.6e-08 0.09 0.00 0.27 FALSE
26 The Cancer Genome Atlas Colon Adenocarcinoma BBS7 0.05 0.00 blup 47 0.02 1.9e-02 7.20 -7.2 6.7e-13 -0.03 0.02 0.16 FALSE
27 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma BBS7 0.04 0.02 blup 47 0.03 1.3e-04 -5.99 -6.0 2.6e-09 -0.03 0.05 0.91 FALSE
28 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CCNA2 0.03 0.01 blup 34 0.02 1.5e-03 -7.71 8.6 7.7e-18 0.02 0.00 0.97 TRUE
29 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma BBS7 0.04 0.04 lasso 2 0.03 6.1e-04 -7.75 -7.8 9.4e-15 -0.03 0.00 1.00 FALSE
30 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FGF2 0.06 0.04 blup 65 0.05 4.4e-06 7.09 6.8 1.5e-11 0.85 0.01 0.99 FALSE
31 The Cancer Genome Atlas Lung Squamous Cell Carcinoma EXOSC9 0.03 0.02 lasso 2 0.02 1.0e-03 7.38 7.9 2.3e-15 0.01 0.06 0.50 FALSE
32 The Cancer Genome Atlas Prostate Adenocarcinoma NUDT6 0.10 0.07 lasso 6 0.07 1.0e-07 5.78 5.4 6.1e-08 0.71 0.97 0.02 FALSE
33 The Cancer Genome Atlas Thyroid Carcinoma EXOSC9 0.04 0.05 lasso 2 0.04 7.1e-05 7.18 8.1 4.7e-16 0.03 0.03 0.95 FALSE