Best TWAS P=9.19e-36 · Best GWAS P=2.59e-44 conditioned to 0.578
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | GORAB | 0.14 | 0.12 | lasso | 8 | 0.14 | 9.9e-17 | -5.6 | 10.3 | 4.4e-25 | 0.60 | 0.98 | 0.02 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | KIFAP3 | 0.08 | 0.06 | lasso | 5 | 0.06 | 1.8e-07 | 5.3 | -5.5 | 3.3e-08 | -0.09 | 1.00 | 0.00 | TRUE |
3 | GTEx | Artery Aorta | C1orf112 | 0.10 | 0.00 | enet | 15 | 0.01 | 1.4e-01 | 4.2 | 6.2 | 6.1e-10 | 0.34 | 0.14 | 0.34 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | KIFAP3 | 0.14 | 0.05 | lasso | 20 | 0.13 | 7.0e-10 | -1.1 | -8.5 | 1.5e-17 | -0.36 | 0.98 | 0.01 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | PRRX1 | 0.07 | 0.06 | lasso | 4 | 0.06 | 3.7e-05 | -7.3 | -9.0 | 2.4e-19 | -0.61 | 0.85 | 0.05 | TRUE |
6 | GTEx | Heart Left Ventricle | GORAB | 0.16 | 0.08 | enet | 22 | 0.03 | 6.9e-03 | -4.9 | 7.0 | 3.3e-12 | 0.27 | 0.20 | 0.22 | FALSE |
7 | GTEx | Lung | GORAB | 0.15 | 0.08 | enet | 23 | 0.10 | 6.2e-08 | -4.9 | 8.7 | 2.4e-18 | 0.52 | 0.51 | 0.36 | FALSE |
8 | GTEx | Nerve Tibial | GORAB | 0.09 | 0.02 | enet | 7 | 0.02 | 1.3e-02 | -6.8 | 5.2 | 1.9e-07 | 0.16 | 0.21 | 0.03 | TRUE |
9 | GTEx | Pituitary | GORAB | 0.22 | 0.09 | lasso | 7 | 0.10 | 2.0e-03 | 12.2 | 12.5 | 9.2e-36 | 0.83 | 0.06 | 0.64 | TRUE |
10 | GTEx | Skin Sun Exposed Lower leg | GORAB | 0.07 | 0.01 | lasso | 5 | 0.00 | 4.2e-01 | 12.3 | 9.8 | 1.3e-22 | 0.74 | 0.06 | 0.33 | FALSE |
11 | GTEx | Uterus | SCYL3 | 0.29 | 0.16 | lasso | 11 | 0.12 | 1.7e-03 | -5.4 | -5.2 | 1.5e-07 | -0.02 | 0.14 | 0.08 | TRUE |
12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | GORAB | 0.09 | 0.05 | lasso | 1 | 0.03 | 5.5e-03 | -5.7 | 5.7 | 1.4e-08 | 0.25 | 0.03 | 0.17 | TRUE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GORAB | 0.07 | 0.01 | blup | 33 | 0.05 | 6.6e-06 | -6.8 | 9.9 | 3.2e-23 | 0.61 | 0.01 | 0.94 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | GORAB | 0.11 | 0.07 | enet | 7 | 0.07 | 2.3e-07 | -5.0 | 8.6 | 1.0e-17 | 0.52 | 0.60 | 0.29 | TRUE |