Hub : Genes

C1orf112

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.161	0.0340	7.5e-13	0.090	0.139	0.151	0.156	0.129	4.4e-11	1.3e-16	6.6e-18	1.7e-18	1.8e-15
2	GTEx	Artery Aorta	0.099	0.0400	2.7e-03	0.001	NA	0.006	NA	-0.002	2.6e-01	NA	1.4e-01	NA	4.4e-01
3	GTEx	Brain Cerebellar Hemisphere	0.348	0.1080	1.0e-03	0.142	NA	0.214	NA	0.227	1.7e-04	NA	3.4e-06	NA	1.6e-06
4	GTEx	Brain Cerebellum	0.502	0.0820	5.7e-09	0.323	NA	0.249	NA	0.364	2.7e-10	NA	5.8e-08	NA	1.1e-11
5	GTEx	Heart Atrial Appendage	0.140	0.0610	1.0e-02	0.038	NA	0.024	NA	0.024	8.1e-03	NA	3.0e-02	NA	2.9e-02
6	GTEx	Nerve Tibial	0.188	0.0537	1.4e-06	0.061	NA	0.059	NA	0.083	3.9e-05	NA	5.2e-05	NA	1.8e-06
7	GTEx	Skin Not Sun Exposed Suprapubic	0.155	0.0610	2.0e-03	-0.005	NA	0.080	NA	-0.001	8.8e-01	NA	3.7e-05	NA	3.4e-01
8	GTEx	Testis	0.154	0.0500	9.4e-05	0.042	NA	0.051	NA	0.063	6.0e-03	NA	2.5e-03	NA	8.9e-04
9	TCGA	Liver Hepatocellular Carcinoma	0.142	0.0730	3.0e-03	0.038	0.084	0.054	NA	0.053	6.7e-03	8.6e-05	1.5e-03	NA	1.6e-03
10	TCGA	Thyroid Carcinoma	0.040	0.0210	2.0e-03	0.023	0.024	0.022	NA	0.029	2.4e-03	1.8e-03	3.0e-03	NA	6.7e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.5	0.7	2.7	0.3	0.3	-0.5	-0.4	-0.9	-0.3	0.5	1.6	-1.2	-1.1
Bipolar Disorder or Schizophrenia	0.5	1.2	2.9	1.1	-0.4	-0.6	-0.6	-1.4	0.3	1.1	1.6	-1.7	-1.4
Depressed Affect (Nagel 2018)	0.8	1.7	6.2	0.8	1.5	1.6	1.2	1.3	1.3	2.5	-0.1	0.2	-0.0
Depression (Nagel 2018)	0.2	0.4	1.4	0.4	1.2	-0.0	0.1	0.5	0.3	1.1	0.5	0.2	0.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.6	0.8	1.0	0.9	1.3	1.1	1.1	-1.2	-0.1	-1.0	-1.2
Neuroticism (Nagel 2018)	0.2	0.5	1.2	0.5	1.1	0.9	0.5	0.6	0.3	1.1	0.9	-0.3	-0.1
Schizophrenia (2018)	0.3	0.7	1.5	1.1	-0.8	-0.3	-0.4	-1.1	0.6	0.9	0.7	-1.2	-0.9
Schizophrenia vs Biploar Disorder	0.4	0.5	1.3	0.6	-0.9	-0.7	0.1	-0.7	0.8	0.1	0.7	-1.1	-0.7
Worry (Nagel 2018)	0.3	0.5	3.1	0.7	0.2	0.1	-0.2	0.2	-0.7	-0.2	1.8	-0.8	-0.7
Alzheimer’s Disease (in mother)	0.5	0.5	2.1	0.9	0.1	0.0	0.7	0.2	0.3	0.3	0.7	-1.4	-1.1
Alzheimer’s Disease (in father)	0.5	0.6	1.7	-0.7	1.0	-0.0	-0.6	-0.1	1.3	-0.1	-1.2	0.6	-0.2
Alzheimer’s Disease (including proxy)	0.4	0.6	1.3	-0.3	-0.4	-0.4	-0.8	-0.8	-0.2	-1.1	0.6	-1.0	-1.1
Crohns Disease (2017)	0.6	1.4	4.5	0.9	-0.1	1.0	1.0	1.0	1.2	-0.0	-2.1	0.7	1.9
Irritable Bowel Disease (IBD)	1.2	2.8	11.6	-0.6	0.9	0.9	0.2	0.6	0.2	0.7	-3.3	1.6	3.4
Ulcerative Colitis (UC)	1.6	3.0	11.2	-1.4	1.4	0.5	-0.7	-0.0	-0.4	1.1	-3.1	1.8	3.3
Major Depression (MDD)	0.4	0.5	3.2	0.1	0.9	-0.1	-0.0	-0.1	1.8	0.9	-0.2	0.1	-0.7
Reaction Time	0.7	1.3	3.4	0.4	-1.8	-1.1	-0.7	-1.0	-0.5	0.8	1.6	-1.4	-1.2
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.7	1.3	0.9	1.6	1.7	1.6	1.1	0.8	-1.3	0.2	0.2
Breast Cancer	0.7	1.7	4.0	1.6	-0.7	1.5	2.0	1.3	1.9	1.0	-1.2	0.3	0.2
Ovarian Cancer	0.8	1.1	3.3	-1.8	-1.0	-1.0	-1.2	-0.8	-0.9	-0.3	-0.7	0.4	1.3
Prostate Cancer	0.2	0.3	0.5	-0.4	-0.7	-0.6	-0.5	-0.5	-0.4	0.0	-0.3	0.7	0.5
Age at First Birth	0.8	1.2	3.5	-1.0	0.5	-0.2	-0.4	0.4	-0.2	-1.1	-1.7	1.9	1.7
Bipolar Disorder (2011)	0.7	0.6	2.5	-0.3	0.2	-0.9	-0.8	-0.9	-0.6	0.1	0.9	-0.6	-1.6
Body Mass Index (BMI) (2010)	0.4	0.5	2.8	-0.6	1.7	0.4	0.2	0.3	0.6	-0.6	-0.8	0.7	0.3
Coronary Artery Disease (CAD)	0.5	0.6	3.1	0.5	-0.4	-0.6	-0.1	-0.8	-0.3	1.8	0.9	-0.5	-0.6
Crohns Disease (2012)	0.4	0.7	2.1	1.5	-0.7	0.7	1.2	0.8	1.1	-0.2	0.0	-0.9	0.1
Mean Putamen Volume	0.4	0.4	1.3	0.6	-1.0	-0.2	-0.1	-0.8	-0.4	1.1	0.3	-0.1	0.7
Fasting Glucose	1.7	2.1	5.2	2.0	1.2	1.4	2.3	1.1	1.8	-0.6	-0.1	-1.2	-1.4
HbA1C	0.8	0.8	4.5	-0.4	0.7	0.4	-0.1	-0.5	-0.3	-2.1	-0.7	1.0	1.1
HDL Cholesterol	0.9	1.5	2.7	-0.8	-1.1	-1.6	-1.4	-1.6	-1.1	-0.5	1.5	-1.1	-1.1
LDL Cholesterol	0.4	0.6	2.8	-0.3	-0.5	-0.9	-0.5	-0.9	0.5	0.1	0.7	-0.4	-1.7
Lupus	0.3	0.5	1.4	0.5	0.2	-0.4	0.3	-0.1	-0.5	-0.8	1.2	-0.9	-1.1
Neuroticism (2016)	1.4	2.0	6.1	0.6	2.5	1.0	1.7	1.3	1.3	2.4	-0.4	0.0	0.0
Primary Biliary Cirrhosis	1.2	1.8	6.1	0.2	-0.1	-0.3	0.0	-1.0	-0.1	-0.1	2.5	-2.2	-2.3
Rheumatoid Arthritis	0.3	0.4	2.6	-0.2	1.6	0.6	0.5	0.3	-0.1	-0.9	0.3	-0.2	-0.1
Schizophrenia (2014)	0.6	1.4	2.8	1.3	-1.2	-0.6	-0.5	-1.3	0.6	1.1	1.4	-1.7	-1.4
Triglycerides	0.3	0.6	1.6	0.3	1.3	0.9	0.7	0.8	1.1	-0.6	-0.4	0.2	-0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.7	-0.0	-0.1	0.1	0.2	0.3	-0.2	-0.4	0.8	-0.5	-0.2
Ulcerative Colitis	0.8	1.2	4.7	-1.3	0.3	-0.2	-0.8	-0.6	-0.6	-0.1	-1.6	1.1	2.2
Blood Eosinophil Count	1.4	10.5	29.4	-2.4	-4.0	-5.1	-4.3	-5.4	-2.4	-0.4	1.5	-0.4	0.1
Blood Platelet Count	0.5	5.3	13.8	-1.4	-1.7	-3.4	-2.7	-3.7	-1.4	-2.1	2.9	-1.0	0.2
Blood Red Count	0.4	3.6	8.3	2.2	1.2	2.9	2.8	2.8	1.7	1.0	-0.6	-0.6	-1.3
Blood White Count	0.3	2.1	5.5	1.3	-0.1	1.6	0.5	2.1	1.2	0.9	-1.3	1.4	2.4
Heel T-Score	0.2	1.8	7.3	0.8	2.7	0.9	0.3	0.1	0.2	-2.7	0.6	-0.7	-1.1
BMI	0.2	0.9	2.3	1.0	-1.1	-0.2	0.9	-0.3	-0.6	1.5	1.1	-0.8	-1.1
Height	0.4	8.1	29.4	-1.5	2.3	-0.1	0.4	1.1	0.3	0.5	-5.4	4.6	4.6
Waist Hip Ratio (WHR)	1.1	5.0	24.1	-1.5	4.9	-2.3	0.7	-1.0	0.7	3.1	-1.6	1.4	1.3
Systolic Blood Pressure	0.2	0.8	3.4	-1.6	0.8	-0.4	0.0	-0.4	-1.8	0.5	0.2	0.8	-0.1
Smoking Status	1.7	4.0	10.7	-1.0	3.3	1.7	1.2	1.8	0.2	1.6	-2.3	2.5	2.6
Allergy or Eczema	1.0	2.6	4.2	-0.9	-2.0	-1.7	-1.6	-0.9	-1.4	-0.9	2.1	-2.0	-1.9
Cardiovascular Disease	0.2	0.6	2.9	-0.5	-0.8	-0.5	-0.0	-0.3	-1.7	-0.1	1.1	-0.6	-0.3
Hypothyroidism (self reported)	0.6	1.4	2.8	-1.0	-0.4	-1.6	-1.6	-1.7	-1.3	-1.3	1.0	0.3	-0.1
Respiratory disease	0.2	0.5	1.3	0.7	0.4	-0.3	0.8	-0.2	0.9	0.7	0.6	-1.1	-1.0
Type 2 Diabetes (T2D) (2018)	0.6	1.2	3.6	-0.7	0.6	-1.1	-0.3	-0.8	-1.2	-1.9	1.5	-0.7	-0.9
Lung FEV1/FVC ratio	0.3	1.4	3.8	-0.5	-0.4	-1.9	-1.2	-1.7	-1.3	-0.2	1.6	-0.8	-0.7
Lung FVC	0.3	1.6	4.0	-1.5	-0.2	-2.0	-2.0	-1.5	-1.6	-0.1	0.9	-0.1	-0.6
Neuroticism	0.4	1.0	2.4	1.0	1.0	1.6	0.9	1.3	1.2	1.1	0.2	0.0	0.4
Chronotype (morning person)	0.2	0.4	1.8	1.0	-1.3	0.5	0.1	0.0	-0.6	0.1	0.6	-0.3	-0.3
Hair Pigment	0.0	1.2	3.8	-1.2	0.4	0.2	-0.7	0.6	-0.8	-0.1	-1.3	1.9	1.9
Tanning	0.1	1.7	8.8	1.4	-0.2	0.8	1.4	0.9	0.4	3.0	-1.2	0.8	1.0
Hand grip strength (left)	0.1	0.2	0.8	0.1	-0.3	0.9	0.1	0.4	0.4	0.6	-0.7	0.3	-0.1
Number of treatments/medications taken	0.4	0.7	2.3	-1.5	0.3	-0.8	-1.0	-0.3	-1.1	-1.1	0.7	-0.4	-0.0
Average weekly spirits intake	4.1	5.1	12.5	-3.5	-0.1	-3.3	-2.6	-2.2	-3.1	-1.2	-0.3	1.5	1.6
Sensitivity / hurt feelings	0.5	0.8	2.6	0.8	1.6	1.0	0.8	1.0	1.4	-0.5	0.2	-0.5	-0.2
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.8	-0.6	0.2	-0.9	-1.1	-1.1	-0.7	0.6	1.3	0.0	-0.1
Hearing difficulty/problems: Yes	0.4	0.6	1.4	0.6	-0.7	1.0	1.2	1.0	0.4	-0.9	-0.6	0.3	0.1
Relative age of first facial hair	0.6	1.2	3.1	-0.2	-1.8	-1.0	-1.2	-0.9	-0.4	-0.6	-1.1	1.2	1.6
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	3.4	-1.9	-0.1	-1.6	-1.4	-1.3	-0.7	-0.2	-0.1	0.4	0.7
Ever used hormone-replacement therapy (HRT)	2.6	3.3	13.1	-0.3	-0.1	-1.3	-0.6	-2.0	-1.0	-3.6	2.4	-1.3	-2.2
Ever had hysterectomy (womb removed)	1.7	1.9	6.6	0.1	2.6	0.2	1.6	0.9	1.9	1.3	0.0	-0.9	-1.7
Systolic blood pressure, automated reading	0.2	0.5	2.5	-0.9	-0.4	-0.9	0.0	-0.8	-1.6	-0.6	0.4	0.0	-0.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	-0.8	-0.3	-0.6	-0.5	-0.4	-0.2	-0.8	-0.1	0.3	0.7
Angina	2.2	2.9	6.4	-0.6	-2.3	-2.3	-1.3	-1.7	-1.0	-0.5	2.5	-2.0	-1.2
Medication for hormone replacement therapy	1.8	2.0	6.0	-1.8	-0.2	-2.4	-1.7	-2.4	-1.1	-0.2	1.0	0.2	0.0
Vitamin and mineral supplements	0.7	1.0	2.2	-1.1	0.3	-1.1	-1.1	-1.0	-1.5	0.9	-0.8	0.9	1.1
Supplements: Zinc	0.8	0.9	2.5	1.2	0.1	1.6	0.4	1.2	1.2	-0.5	-1.1	0.9	0.2
Medication: Co-codamol	1.1	1.3	3.0	-0.1	0.2	-1.3	0.1	-1.0	-0.7	-1.7	1.6	-1.6	-1.3
Medication: Metformin	0.2	0.3	1.5	-0.6	0.3	-1.2	-0.6	-0.7	-0.2	-0.2	-0.3	-0.1	-0.0
Diabetes (father)	0.2	0.3	1.0	-0.6	0.9	-0.1	0.2	-0.7	-0.1	-0.1	1.0	-0.4	-0.2
Diabetes (mother)	0.0	0.1	0.2	0.2	-0.1	0.0	0.3	0.3	0.2	-0.2	-0.4	0.0	-0.2
Severe depression (siblings)	0.5	0.5	1.7	-0.6	0.7	-0.1	-0.8	-0.4	-0.2	-1.3	0.8	-1.0	-0.7
Pack years adult smoking proportion	0.8	1.1	2.6	-1.6	0.5	-1.6	-1.2	-1.6	-0.3	-0.8	0.2	1.0	0.5
Impedance of leg (right)	0.4	2.0	4.8	-1.9	0.3	-1.2	-2.2	-2.0	-1.1	-1.7	1.1	-0.4	-1.0
Leg fat-free mass (left)	0.6	3.2	9.4	1.5	0.8	1.0	2.3	1.7	1.3	3.1	-2.1	1.4	1.6
Trunk fat percentage	0.2	0.7	1.7	1.0	-0.8	-0.1	0.7	0.3	-0.8	0.3	1.0	-0.9	-1.3
Hand grip strength (right)	0.1	0.2	0.6	0.0	-0.6	0.7	0.0	0.0	-0.2	-0.8	0.6	-0.3	-0.8
Townsend deprivation index at recruitment	0.5	0.8	3.5	-0.4	1.9	1.2	1.0	0.9	-0.0	0.5	-0.4	0.6	0.2
Current tobacco smoking	1.1	1.9	5.5	-1.8	1.4	-0.4	-0.9	-0.5	-0.8	0.9	-1.1	2.4	2.0
Average weekly fortified wine intake	0.2	0.2	0.5	-0.6	0.1	-0.7	-0.7	-0.5	-0.6	0.5	0.3	-0.0	0.0
Maternal smoking around birth	1.0	1.5	4.6	-2.1	1.6	-1.0	-0.9	-0.6	-0.9	-0.3	-0.8	1.9	0.3
Fed-up feelings	0.5	0.9	3.0	1.0	1.2	0.9	1.4	0.6	0.9	1.7	0.3	-0.1	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.5	-0.2	0.7	0.1	0.1	-0.1	-0.2	0.3	0.6	0.2	0.7
Relative age voice broke	0.5	0.8	3.8	0.2	-1.4	0.0	-0.9	-0.7	-0.2	-1.9	0.7	-0.8	-0.0
Taking other prescription medications	0.4	0.7	3.1	-1.8	1.0	-0.1	-0.6	0.6	-0.3	-1.1	-0.2	0.2	0.8
Age when periods started (menarche)	0.7	1.7	7.3	-0.9	-2.7	-0.5	-2.0	-0.7	-1.4	-0.9	0.3	0.8	0.7
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	13.4	0.3	3.7	0.9	1.5	1.3	2.7	0.2	-0.5	-0.1	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	6.7	2.5	1.8	1.7	2.2	1.7	1.3	0.8	1.3	-1.6	-2.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.1	0.3	0.5	0.5	0.6	0.8	1.0	-0.2	-0.1	-0.3	-0.6
Qualifications: CSEs or equivalent	1.8	2.3	4.9	1.5	1.2	1.7	1.9	1.6	1.8	2.2	-0.9	0.9	0.8
Serious illness, injury or assault to yourself	3.5	4.2	8.5	-2.8	-0.9	-2.1	-2.5	-1.7	-1.4	0.2	-1.9	2.4	2.9
High blood pressure	0.3	0.9	4.4	-1.2	-0.6	-0.8	-0.9	-0.3	-2.1	-0.6	0.3	0.4	0.5
Hayfever, allergic rhinitis or eczema	0.5	1.2	2.8	-1.2	-1.5	-1.3	-1.7	-0.7	-0.7	-0.6	1.0	-1.0	-0.7
Multivitamins +/- minerals	0.1	0.2	0.6	-0.1	-0.2	0.1	0.1	0.3	0.5	-0.7	0.4	-0.3	-0.8
Stomach or abdominal pain in last month	1.5	1.9	4.8	-1.8	-0.1	-1.1	-2.2	-1.2	-1.4	-1.5	-1.3	0.9	1.3
Supplements: Glucosamine	0.3	0.3	1.4	0.7	-0.5	0.6	1.2	0.7	0.5	-0.2	-0.2	-0.5	-0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	-0.6	0.2	-0.2	-0.4	-0.2	0.3	-0.2	-0.7	0.7	0.5
Medication: Atenolol	0.8	1.0	3.3	-0.8	-1.1	-1.6	-0.2	-1.2	-1.8	0.0	0.2	-0.1	0.4
Medication: Levothyroxine sodium	1.4	2.4	5.2	-1.3	-0.6	-1.8	-2.1	-1.5	-2.3	-2.2	1.3	0.3	-0.1
Sitting height	0.2	1.2	2.6	0.9	1.6	1.2	1.5	0.8	1.5	0.9	-0.9	-0.3	0.1
Chronic bronchitis/emphysema (father)	0.8	1.0	5.0	0.6	0.1	-0.2	0.2	-0.5	0.4	-1.1	1.2	-1.1	-2.2
High blood pressure (mother)	0.6	0.8	5.2	0.1	-2.3	-0.3	-0.9	-0.2	-0.8	-0.3	1.2	-0.4	-0.2
Body mass index (BMI)	0.1	0.6	2.7	0.8	-0.1	0.2	1.2	0.7	-0.5	1.6	-0.3	0.2	-0.3
Impedance of leg (left)	0.4	1.8	5.2	-1.4	0.4	-0.7	-2.1	-1.5	-0.5	-2.3	1.2	-0.8	-1.3
Leg predicted mass (left)	0.6	3.1	8.8	1.7	0.7	1.1	2.4	1.7	1.4	3.0	-1.9	1.2	1.4
Trunk fat mass	0.1	0.4	1.1	0.9	-0.3	0.0	1.0	0.5	-0.7	0.8	0.2	-0.2	-0.6
Waist circumference	0.3	1.2	4.2	0.4	1.7	-0.4	1.7	0.4	0.1	2.0	-1.1	0.6	0.1
Number of incorrect matches in round	1.4	2.3	4.0	-1.9	0.6	-1.5	-1.5	-1.1	-2.0	1.6	-0.8	2.0	1.4
Past tobacco smoking	1.1	2.0	7.9	1.2	-2.8	-0.5	-0.5	-0.9	-0.2	-1.2	1.9	-1.5	-1.3
Alcohol usually taken with meals	0.4	0.7	2.3	0.5	-1.5	0.9	0.3	0.9	-0.9	-1.1	0.3	-0.2	0.4
Nervous feelings	0.3	0.6	2.3	-0.2	-0.0	-1.0	-0.9	-0.6	-0.6	-1.5	0.2	0.7	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	1.2	0.7	0.3	-0.2	0.2	-0.3	0.4	0.2	1.1	-0.3	-0.5
Hearing difficulty/problems with background noise	0.9	1.4	4.0	0.1	0.4	1.1	1.4	2.0	1.1	-1.2	-1.4	1.0	1.1
Hair/balding pattern: Pattern 2	2.0	2.5	6.6	0.1	-1.9	0.8	0.2	1.1	0.6	2.2	-2.6	2.2	1.7
Had menopause	0.6	0.8	2.8	0.3	-0.0	0.1	0.5	-0.1	0.1	-1.2	1.6	-1.1	-1.7
Had other major operations	0.7	0.8	2.3	-0.9	0.2	-0.9	-0.8	-1.1	-0.8	-1.5	1.2	-0.9	-0.2
Forced vital capacity (FVC)	0.1	0.3	0.9	0.2	0.9	0.5	0.2	0.4	0.9	0.9	-0.6	-0.3	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.1	8.4	2.5	1.3	1.1	1.9	1.1	1.4	0.3	1.3	-2.3	-2.9
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	7.5	0.5	2.7	0.3	0.2	-0.3	1.8	-0.2	0.4	-0.1	-0.6
Qualifications: None of the above	0.2	0.5	1.6	-1.2	1.2	-0.0	0.4	0.3	-0.4	-0.6	0.4	-0.0	-0.7
Financial difficulties in last 2 years	1.7	2.2	3.7	1.7	1.9	1.8	1.9	1.8	1.6	1.5	0.6	-0.4	-0.7
Mouth/teeth dental problems	0.7	1.1	3.4	-1.2	-0.6	-0.6	-1.8	-1.2	-1.4	-0.4	1.3	-0.4	-0.1
Heart attack	0.8	1.0	5.3	-1.0	-0.6	-1.4	-0.6	-0.3	-2.3	0.3	0.9	0.3	-0.2
Allergy	0.5	1.2	2.7	1.4	0.5	1.6	1.6	1.3	0.5	-0.7	-1.2	0.7	0.5
Pain all over the body in last month	1.2	1.2	2.6	-1.6	-0.3	-1.4	-1.6	-1.6	-1.5	-0.4	0.4	0.0	0.4
Diabetes (self-reported)	0.2	0.3	1.2	-0.6	0.5	-0.6	0.3	-0.2	-0.1	-1.1	0.5	-0.5	-0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.4	-0.3	0.6	0.1	-0.3	0.3	0.5	-0.2	0.5	-0.0	-0.5
Medication: Ramipril	0.3	0.4	1.7	-0.2	0.1	-0.0	0.9	0.7	-1.3	-0.7	0.3	-0.2	0.3
Medication: Simvastatin	0.2	0.3	1.0	-0.3	-0.9	-0.6	0.0	0.2	-1.0	0.8	0.0	-0.1	0.6
Fluid intelligence score	0.5	1.1	2.2	1.1	1.5	1.4	1.1	0.9	1.3	0.0	-1.0	0.6	0.4
Illnesses of siblings	0.4	0.6	3.6	-0.1	1.0	0.2	-0.7	-0.5	1.9	0.8	-0.2	-0.4	-0.1
Neuroticism score	0.8	1.6	4.7	1.3	2.2	1.6	1.4	1.5	1.6	1.0	0.1	-0.0	0.0
Weight	0.2	1.2	3.7	1.0	0.7	0.6	1.6	1.1	0.3	1.9	-1.3	0.9	0.5
Impedance of arm (right)	0.3	1.5	5.1	1.0	-1.4	-0.0	-0.1	-0.6	-0.8	-1.4	2.2	-1.5	-1.2
Arm fat percentage (right)	0.3	1.0	1.8	1.3	-0.8	-0.1	1.2	0.2	-1.2	1.2	1.0	-0.9	-1.2
Trunk fat-free mass	0.5	2.9	7.6	0.8	1.2	0.7	1.7	1.2	1.4	2.6	-2.8	1.7	1.7
Hip circumference	0.2	0.9	2.6	1.6	-1.0	1.1	1.4	1.1	0.2	0.8	-0.3	0.1	-0.2
Time employed in main current job	1.0	1.1	3.5	-0.4	-1.0	-0.7	-0.4	-0.8	-0.7	-0.4	1.9	-1.5	-1.5
Alcohol intake versus 10 years previously	1.1	1.6	5.3	0.1	2.3	1.3	1.4	1.4	0.5	-0.2	-1.5	1.4	0.8
Father’s age at death	1.2	1.7	4.0	0.3	-1.8	-0.7	-0.9	-1.6	-1.6	-0.6	2.0	-1.5	-0.5
Worrier / anxious feelings	1.0	1.9	5.6	2.4	0.2	1.4	1.7	1.4	1.4	0.6	1.1	-1.4	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.2	1.1	1.1	0.6	0.6	0.2	0.6	0.3	1.1	-0.5	-0.2
Falls in the last year	1.0	1.3	6.7	-1.5	2.6	-0.0	-0.1	0.3	1.2	1.2	-0.7	0.9	0.3
Hair/balding pattern: Pattern 3	0.7	1.0	2.9	-0.1	-1.0	-0.4	-0.6	-0.2	-0.8	-1.6	1.3	-1.7	-0.7
Number of live births	0.5	0.6	2.1	-0.5	-0.3	-1.0	-1.2	-0.7	-0.6	-1.5	-0.2	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.0	1.0	0.2	0.5	0.4	0.6	0.9	0.7	-0.2	-0.9	-0.5
Pulse rate	1.0	1.6	7.4	-0.7	-0.3	-1.5	-1.0	-1.6	-0.6	-2.7	1.4	-0.2	-0.4
Happiness	2.1	2.5	8.4	1.5	-2.0	0.7	-0.4	-0.5	-0.2	-0.2	2.6	-2.9	-1.6
Noisy workplace	1.4	1.8	9.2	-0.3	-0.2	0.1	-0.2	0.6	-0.2	0.4	-2.1	1.8	3.0
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.2	1.0	-0.9	-0.7	-0.0	-0.3	0.1	-1.2	1.5	-1.4	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	4.0	-1.8	-0.6	-1.5	-2.0	-1.4	-1.2	-1.3	0.6	0.5	0.4
Mouth/teeth dental problems: Dentures	0.3	0.4	2.1	0.2	-0.2	-0.9	0.5	-0.6	-0.2	-1.4	0.1	-0.7	-0.4
Asthma	0.8	1.7	4.5	1.3	1.1	0.4	1.2	0.3	2.1	0.7	1.3	-1.7	-1.5
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	4.3	0.0	1.5	1.1	0.4	0.7	1.7	0.4	-2.0	2.1	1.6
Medication: Cholesterol lowering	0.3	0.4	1.8	-0.5	-0.7	-0.5	0.3	0.2	-1.4	0.9	-0.3	-0.1	0.4
Depression (self-reported)	1.0	1.3	2.8	1.7	0.5	1.4	1.5	1.5	0.7	1.4	-0.2	-0.1	-0.0
Medication: Lansoprazole	0.4	0.5	1.0	-0.8	-0.6	-0.9	-0.4	-0.4	-0.9	0.0	0.6	-1.0	-0.7
Prospective memory result	0.8	1.0	2.3	-1.5	0.7	-1.0	-0.7	-0.3	-0.7	-0.6	-1.3	1.3	1.2
Lung cancer (father)	0.7	0.8	2.3	0.4	1.4	1.5	1.3	0.9	0.5	0.5	-0.9	0.5	-0.4
Illnesses of mother	0.7	0.9	1.7	0.4	1.3	0.7	1.3	0.3	1.1	1.1	-0.9	0.8	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	3.0	1.2	0.5	0.9	0.5	1.0	1.0	1.7	-1.3	0.3	0.7
Pulse wave Arterial Stiffness index	1.4	1.7	4.4	-1.7	0.0	-0.6	-0.7	-0.3	-1.7	-1.3	-0.6	2.1	1.9
Impedance of arm (left)	0.3	1.4	4.5	1.2	-1.1	0.9	0.1	0.3	-0.4	-1.6	2.1	-1.5	-0.9
Arm fat mass (right)	0.2	0.7	3.0	1.1	-0.3	0.1	1.3	0.4	-0.6	1.7	-0.2	0.1	-0.2
Trunk predicted mass	0.5	3.0	7.5	0.9	1.2	0.7	1.8	1.2	1.5	2.7	-2.7	1.6	1.6
Standing height	0.2	1.7	4.7	0.6	1.2	0.8	0.9	1.0	1.5	1.0	-2.2	1.4	1.8
Length of working week for main job	1.8	2.0	4.3	1.9	0.7	2.0	2.1	1.6	1.4	0.4	0.6	-1.4	-0.8
Exposure to tobacco smoke at home	0.5	0.6	3.1	-0.9	0.3	-0.7	-0.4	-0.8	-0.4	1.8	0.3	0.3	-0.5
Breastfed as a baby	0.8	1.0	2.8	-1.7	0.7	0.2	-0.9	0.3	-0.3	-0.4	-1.2	1.7	1.1
Tense / ‘highly strung’	1.8	2.9	11.0	1.1	-0.7	-0.9	-0.3	-1.3	0.1	-0.1	3.3	-2.6	-2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	3.2	0.5	0.5	-0.1	-0.5	-0.1	1.1	-0.7	1.5	-1.3	-1.8
Hair/balding pattern: Pattern 4	2.3	5.7	38.3	-2.1	6.2	-1.5	-0.6	-1.1	0.6	1.0	1.1	-0.8	-2.7
Birth weight of first child	0.2	0.4	1.3	0.7	-0.2	0.5	1.2	0.4	1.1	0.9	-0.3	0.0	-0.0
Peak expiratory flow (PEF)	0.8	1.8	4.5	1.3	0.8	2.1	1.6	1.7	1.5	1.0	-1.5	-0.0	0.5
Pulse wave reflection index	0.4	0.5	1.4	-1.0	-0.0	0.4	-0.2	0.4	-1.2	-0.2	-0.6	1.1	1.0
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.9	-1.1	0.2	-0.4	-0.9	-1.1	-0.8	-1.7	0.3	0.3	1.0
Loud music exposure frequency	0.4	0.4	1.0	1.0	0.1	-0.5	0.5	0.0	0.8	-0.3	0.9	-1.0	-0.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.1	0.6	-0.1	-0.0	0.6	0.3	0.9	1.1	-0.9	0.1	0.7
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	4.5	2.1	-0.0	0.9	1.6	0.9	1.6	0.8	0.8	-0.8	-2.0
Blood clot in the leg (DVT)	4.0	5.2	34.3	-0.4	2.2	0.2	-0.3	0.6	0.6	5.9	-1.6	1.9	2.2
Medication: Paracetamol	0.1	0.2	1.0	-0.5	1.0	-0.3	-0.1	-0.0	0.4	0.4	-0.3	0.4	0.5
Headache pain in last month	0.1	0.2	0.5	0.3	-0.7	0.5	0.0	-0.0	-0.3	-0.2	0.4	-0.7	-0.3
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	8.1	1.8	1.1	1.8	1.2	1.1	2.9	0.3	-0.6	0.3	-0.3
Glaucoma (self-reported)	1.0	1.2	4.2	0.0	-0.1	-0.3	0.3	-0.5	-0.4	-1.6	1.7	-2.1	-1.4
Gout (self-reported)	0.2	0.3	1.5	-1.2	-0.3	-0.4	-0.1	-0.6	-0.5	-0.3	-0.4	0.6	0.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	4.2	-0.7	-0.8	-1.3	-1.5	-1.2	-1.8	-2.0	1.4	-0.3	-0.1
Medication: Amlodipine	0.4	0.6	1.5	-1.2	1.1	-0.5	-0.0	-0.2	-0.7	-0.5	-0.0	1.0	1.1
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.8	1.2	1.6	1.4	1.7	1.4	1.3	-0.2	0.0	-0.5	-0.3
Birth weight	0.5	1.1	3.8	-0.4	-1.9	-0.4	0.5	0.6	-0.7	0.7	-1.5	0.7	1.6
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.4	1.1	0.4	1.2	0.7	1.1	0.0	-1.0	-0.7	-0.4	-0.7
High blood pressure (siblings)	0.6	0.9	2.8	0.6	0.2	0.5	1.4	1.5	-0.9	-1.7	0.7	-0.3	-0.3
Forced vital capacity (FVC), Best measure	0.3	1.0	2.7	0.7	1.1	0.6	0.4	0.6	1.3	1.6	-1.5	0.4	0.6
Body fat percentage	0.1	0.5	1.4	0.7	-0.3	-0.1	0.8	0.2	-1.0	0.6	0.7	-0.7	-1.2
Leg fat percentage (right)	0.2	0.7	3.7	-0.9	0.0	-0.9	-0.3	-0.6	-1.9	0.6	-0.3	0.5	-0.4
Arm fat-free mass (right)	0.5	2.8	5.8	0.5	2.0	0.8	1.7	1.5	1.9	2.4	-2.4	1.3	1.1
Exposure to tobacco smoke outside home	1.1	1.4	4.3	-1.4	0.5	-0.9	-1.0	-0.3	-0.5	1.0	-1.1	2.1	1.7
Comparative body size at age 10	0.7	2.0	4.6	2.1	1.0	1.8	2.1	1.8	1.0	1.7	0.0	0.1	-0.1
Number of full brothers	1.0	1.3	2.6	1.3	-1.3	1.5	1.5	1.6	-0.3	-1.1	-0.2	0.1	1.0
Worry too long after embarrassment	0.6	1.0	3.2	1.1	0.7	1.7	0.8	1.8	1.4	-0.0	0.3	-0.1	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.7	0.8	-0.6	0.6	-0.6	-0.1	0.3	-0.4	1.3	-0.6	-0.6
Wheeze or whistling in the chest in last year	0.5	0.9	3.1	-1.8	0.3	-1.4	-1.0	-1.3	-0.2	-0.5	-0.1	0.8	0.4
Number of children fathered	0.4	0.5	1.9	-0.7	0.5	0.2	0.1	0.9	0.6	-1.4	-0.4	0.1	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.9	0.1	-0.1	0.4	0.8	0.9	0.4	1.7	-0.2	0.4	-0.1
Age at first live birth	1.4	2.4	5.7	2.4	-1.5	1.2	1.4	0.9	0.8	2.2	1.1	-1.6	-1.7
Pulse wave peak to peak time	1.6	1.9	4.1	1.8	0.2	0.9	1.0	0.5	1.9	1.6	0.4	-2.0	-1.8
Health satisfaction	0.2	0.2	0.6	0.1	-0.6	-0.2	-0.4	-0.5	-0.5	0.4	0.8	-0.7	0.3
Shortness of breath walking on level ground	3.0	3.6	9.1	-3.0	0.6	-2.0	-2.8	-1.8	-2.2	-1.0	-0.4	1.2	2.0
Qualifications: College or University degree	0.6	2.0	4.5	1.3	-1.4	-0.2	-0.0	-0.2	1.9	-1.1	1.5	-2.0	-2.1
Eye problems/disorders: None of the above	3.2	3.6	8.9	2.2	0.7	2.6	2.5	2.2	1.8	3.0	-0.7	0.4	-0.2
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.2	-1.1	1.0	-1.5	-0.2	-1.5	0.1	-0.1	-0.4	0.2	-0.5
Emphysema/chronic bronchitis	1.3	1.5	4.9	-1.6	0.2	-1.6	-0.6	-1.4	-0.2	-2.2	0.8	-0.8	-1.1
Medication for pain relief, constipation, heartburn	0.5	0.9	3.1	0.1	-1.8	-0.9	-0.8	-1.1	-1.2	-0.1	0.6	-0.6	-0.8
Neck or shoulder pain in last month	0.3	0.4	1.8	0.6	1.0	0.3	0.1	0.4	1.3	-0.2	0.1	0.1	-0.3
Medication: Blood pressure	1.3	2.3	9.8	-1.9	-1.3	-1.6	-1.4	-1.1	-3.1	-0.1	0.4	0.2	1.2
Angina (self-reported)	2.9	3.8	8.3	-0.6	-2.5	-2.6	-1.5	-2.1	-1.2	-0.8	2.9	-2.3	-1.5
Migraine (self-reported)	0.4	0.5	1.7	-0.6	0.9	0.9	0.6	0.2	0.0	1.3	0.2	-0.9	0.2
Medication: Ibuprofen	1.1	1.4	2.8	0.2	1.7	0.9	0.6	0.6	1.6	0.6	-1.5	1.6	1.2
Medication: Allopurinol	0.4	0.6	1.7	-1.3	0.2	-1.3	0.0	-1.1	-0.9	-0.3	0.4	-0.3	-0.1
Medication: Omeprazole	1.0	1.2	3.8	-1.3	0.1	-2.0	-1.3	-1.4	-0.6	-1.1	-0.1	0.9	0.7
Medication: Seretide 50 evohaler	0.5	0.6	1.3	-0.5	0.2	-1.0	-0.5	-0.7	-0.9	-0.2	1.1	-1.1	-0.9
Mean time to correctly identify matches	0.7	1.4	4.9	-0.7	-2.2	-1.3	-1.2	-1.1	-1.5	-0.8	0.9	-0.4	-0.4
Heart disease (mother)	0.2	0.3	0.9	-0.6	0.9	-0.1	-0.4	-0.2	0.1	0.9	0.5	0.4	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.2	1.2	0.5	1.5	1.4	1.5	1.5	1.5	-0.9	0.2	0.3
Whole body fat mass	0.1	0.6	1.9	1.0	0.1	0.3	1.3	0.7	-0.5	1.4	-0.2	0.0	-0.4
Leg fat mass (right)	0.2	0.7	3.1	0.4	0.5	0.3	1.1	0.7	-0.8	1.8	-1.0	0.7	0.2
Arm predicted mass (right)	0.7	3.6	8.2	0.7	1.8	1.0	1.9	1.7	1.8	2.8	-2.9	1.8	1.6
Pulse rate, automated reading	1.2	3.8	7.7	-1.0	-1.6	-2.1	-1.5	-2.3	-2.4	-1.7	2.8	-1.3	-2.0
Alcohol intake frequency.	0.2	0.5	1.5	0.0	0.9	1.2	0.6	1.2	-0.2	-0.5	-0.1	0.3	0.7
Comparative height size at age 10	0.5	3.0	6.5	0.8	1.9	1.3	2.2	1.7	1.9	2.5	-1.8	1.3	0.8
Number of full sisters	1.2	1.5	3.6	-0.1	1.4	1.0	0.9	1.1	0.4	1.9	-1.4	1.4	1.4
Suffer from ‘nerves’	0.8	1.3	4.2	-0.5	-0.3	-1.0	-1.1	-0.7	-2.0	-2.0	1.3	-0.3	0.0
Overall health rating	0.3	0.6	1.7	-1.3	0.8	-0.7	-0.4	-0.7	-0.7	0.8	1.0	0.1	0.3
Chest pain or discomfort	0.6	0.8	2.2	-0.4	-0.8	-1.5	-0.5	-1.0	-1.2	-0.2	1.1	-1.1	-0.4
Had major operations	0.7	0.8	4.3	-1.4	2.1	-0.6	-0.5	-0.7	0.4	0.1	-0.0	0.2	-0.4
Age at last live birth	1.4	2.0	3.9	1.9	-0.7	1.2	1.6	1.0	1.2	2.0	0.8	-1.2	-1.7
Family relationship satisfaction	0.9	1.1	3.5	0.7	1.1	1.6	0.3	0.4	1.9	1.5	-0.5	-0.5	0.5
Leg pain on walking	1.9	2.4	7.5	-2.0	1.5	-0.7	-1.2	-0.2	-1.3	-0.2	-1.2	2.3	2.7
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	3.0	0.3	-0.9	0.1	-0.0	0.0	-0.3	-1.4	-0.9	1.1	1.7
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.8	-0.9	-0.3	0.1	-0.6	0.2	-1.5	-1.9	-0.7	0.9	1.0
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	6.6	2.1	1.6	2.6	2.0	1.6	2.0	0.1	0.3	-1.4	-1.6
Medication: Aspirin	0.5	0.7	1.2	0.5	0.9	0.9	1.0	1.1	0.4	0.7	1.1	-0.3	-0.8
Supplements: Vitamin C	0.9	1.0	2.7	1.2	0.1	1.6	1.1	1.2	1.4	-0.9	0.2	-0.8	-0.6
Knee pain experienced in last month	0.4	0.7	1.3	-1.0	-0.0	-0.9	-1.1	-0.9	-1.1	-0.2	-0.5	1.0	0.7
Hypertension (Self-reported)	0.5	1.3	5.8	-1.7	-0.2	-0.7	-1.1	-0.4	-2.4	-0.5	0.0	0.9	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.4	5.2	15.5	2.3	-0.6	-0.6	1.0	-0.7	1.0	-1.3	3.3	-3.9	-3.9
Illnesses of father: Heart disease	0.6	0.8	2.2	-0.2	-0.4	-1.5	-0.5	-0.3	0.0	-0.3	1.5	-1.1	-1.3
Illnesses of siblings: Diabetes	1.3	1.6	4.0	-1.3	-1.4	-1.9	-1.2	-2.0	-1.6	-0.3	-0.1	0.5	0.3
Smoking status: Previous	1.5	2.3	8.5	-0.1	2.9	1.6	1.4	1.9	0.7	1.1	-1.9	0.8	0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	5.9	2.0	0.8	2.4	1.6	1.2	1.9	0.9	-1.1	0.7	0.9
Whole body fat-free mass	0.5	3.1	8.5	1.2	1.1	0.9	2.0	1.5	1.6	2.9	-2.5	1.5	1.5
Leg fat-free mass (right)	0.7	3.9	7.6	2.2	0.8	1.5	2.7	2.2	2.0	2.8	-2.0	1.0	1.3
Arm fat percentage (left)	0.3	1.0	2.4	1.6	-0.7	0.6	1.5	0.8	-0.9	1.2	0.7	-0.7	-0.9
Average weekly red wine intake	0.6	0.9	4.5	0.7	-1.6	-0.1	-0.2	0.0	-0.8	0.4	-0.8	0.5	2.1
Handedness (chirality/laterality): Left-handed	1.1	1.3	4.2	1.6	-2.1	-1.1	0.5	-1.2	0.1	0.7	0.7	-0.9	-1.3
Mood swings	1.3	2.3	5.8	1.2	1.8	2.4	1.3	2.0	2.0	1.3	-0.8	0.2	0.3
Loneliness, isolation	0.4	0.5	2.9	-0.6	1.7	-0.0	-0.0	-0.3	1.0	0.8	0.1	-0.0	-0.5
Long-standing illness, disability or infirmity	0.7	1.0	3.2	-1.8	1.1	-1.2	-0.8	-0.7	-0.4	-1.0	-0.5	1.0	0.8
Ever had bowel cancer screening	1.4	1.6	5.6	0.3	-2.2	-0.9	-1.2	-0.4	-1.6	-2.4	-0.4	-0.4	0.5
Diabetes diagnosed by doctor	0.4	0.7	2.6	-1.1	-0.1	-1.2	-0.3	-0.8	-1.1	-1.6	0.1	0.3	0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.2	-1.1	-0.6	0.6	-1.1	0.7	-1.5	0.7	-0.6	1.4	1.4
Friendships satisfaction	1.2	1.5	3.1	1.7	-1.1	1.4	0.8	1.0	0.7	1.0	1.2	-1.6	-1.0
Qualifications: nursing, teaching	0.8	1.3	3.0	0.0	-0.7	-1.5	-0.7	-0.9	-0.4	-1.2	1.4	-1.7	-1.6
Commuting to job workplace: Walk	1.2	1.3	3.9	1.0	-1.2	-0.2	0.4	-0.8	0.4	-0.1	2.0	-2.0	-1.3
Eye problems/disorders: Cataract	1.0	1.2	2.7	-0.8	0.3	-1.6	-1.4	-1.4	-1.2	-1.3	1.0	-0.4	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	8.2	0.7	0.5	1.0	0.6	2.0	1.6	1.0	-2.9	2.1	2.2
Medication for cholesterol	1.6	2.4	6.0	2.1	0.1	2.4	2.0	2.2	1.4	0.8	-0.1	-1.1	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.0	0.0	-1.4	-0.9	-0.5	-0.9	-0.9	0.6	0.2	0.1	0.1
Back pain experienced in last month	1.5	2.2	3.9	1.3	1.2	1.8	1.3	2.0	1.3	1.0	-1.3	1.8	1.4
Mineral and other dietary supplements	0.2	0.3	0.7	0.7	0.6	-0.1	0.5	-0.5	-0.4	0.8	0.6	-0.7	0.1
Breast cancer (self-reported)	0.6	0.7	3.3	-0.4	-0.3	-0.8	-0.2	-1.1	-1.1	0.5	1.8	-0.5	-0.3
Asthma (self-reported)	0.7	1.4	4.6	1.2	1.2	0.5	1.2	0.4	2.1	1.0	0.9	-1.2	-1.2
Osteoporosis (self-reported)	0.4	0.5	1.6	1.3	-0.6	0.3	0.6	0.5	0.3	0.5	0.6	-1.1	-0.7
Osteoarthritis (self-reported)	0.2	0.3	0.9	-0.6	0.8	-0.2	-0.1	0.2	-0.8	-0.4	-0.1	1.0	0.5
Medication: Aspirin	0.8	1.0	2.5	0.8	0.9	1.1	1.6	1.4	0.5	0.8	1.1	-0.6	-1.0
Medication: Gliclazide	0.5	0.5	1.6	-0.9	0.6	-0.2	-0.2	0.5	-0.4	-0.5	-1.3	1.0	0.9
Illnesses of father: None of the above (group 1)	1.1	1.4	3.2	-0.9	-1.8	-0.4	-1.6	-1.4	-1.2	-0.9	1.1	-1.2	-0.7
Smoking status: Current	1.2	1.9	5.0	-1.9	1.1	-0.8	-1.1	-1.0	-1.0	0.7	-0.9	2.2	2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	1.3	0.1	1.1	-0.1	-0.8	-0.1	0.1	0.9	-0.2	-0.0	-0.0
Whole body water mass	0.6	3.2	8.7	1.2	1.2	0.8	2.0	1.5	1.6	3.0	-2.4	1.5	1.5
Leg predicted mass (right)	0.7	3.7	7.6	2.2	0.8	1.5	2.6	2.2	1.9	2.8	-2.0	1.0	1.4
Arm fat mass (left)	0.2	1.0	3.2	1.4	-0.1	0.7	1.7	1.0	-0.3	1.8	-0.3	0.0	-0.3
Number of self-reported non-cancer illnesses	0.8	1.4	3.9	-2.0	1.9	-1.0	-1.3	-0.4	-1.2	0.7	-0.0	1.0	1.0
Average weekly champagne plus white wine intake	1.3	1.7	3.4	-0.5	-1.6	-1.1	-0.9	-1.2	-1.1	-1.8	1.6	-1.3	-1.4
Miserableness	2.1	3.6	6.9	1.1	1.9	2.5	2.1	2.6	2.1	2.5	-1.4	0.3	0.6
Guilty feelings	0.3	0.4	1.1	-0.0	1.1	0.4	-0.6	0.4	0.9	-0.4	-0.6	0.8	0.5
Wears glasses or contact lenses	0.5	0.6	2.2	-0.1	-0.9	-0.5	-0.2	0.2	-1.5	-1.2	0.7	-0.4	-0.0
Ever taken oral contraceptive pill	0.6	0.7	2.7	-0.3	-0.9	-1.6	-1.1	-1.1	-0.9	0.0	-0.1	0.0	0.3
Hearing aid user	1.6	1.8	5.7	-2.3	0.1	-1.3	-1.4	-1.1	-1.3	-2.4	0.5	-0.1	0.5
Mother’s age at death	0.9	1.1	2.2	-0.8	-1.5	-0.2	-1.0	-0.5	-1.2	0.9	-1.1	1.2	1.2
Financial situation satisfaction	0.3	0.4	1.1	0.6	-0.8	-0.3	-0.1	-0.5	-1.0	0.8	0.8	-0.7	0.1
Tinnitus: Yes, now most or all of the time	3.0	3.4	8.4	2.4	0.9	2.6	2.9	2.0	1.1	1.8	0.8	-1.9	-0.7
Commuting to job workplace: Public transport	1.0	1.2	4.2	0.6	-2.1	-0.8	-0.3	-1.3	-0.8	-0.2	1.5	-1.0	-0.9
Eye problems/disorders: Glaucoma	0.8	0.9	1.8	-0.5	-0.3	-0.5	-0.9	-0.9	-0.4	-1.4	1.3	-1.3	-1.2
Medication: Blood pressure	1.4	2.6	6.7	-2.1	-0.1	-1.5	-1.2	-1.3	-1.8	-0.7	-1.3	2.6	2.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.4	-0.4	-0.7	-0.2	-0.9	0.5	-0.3	-0.4	-0.5	1.6	1.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	-0.4	-0.9	-0.1	-0.8	-0.5	-0.2	-1.0	0.8	-0.6	-1.0
High cholesterol (Self-reported)	1.0	1.8	5.9	-0.6	-2.4	-1.7	-1.3	-0.9	-2.1	-0.7	0.9	-0.1	0.1
Medication: Bendroflumethiazide	0.9	1.4	5.5	-1.5	0.8	-0.1	-0.3	0.3	-0.7	0.3	-1.2	2.3	1.9
Medication: Paracetamol	0.2	0.4	1.7	-0.7	1.3	-0.5	-0.2	-0.3	-0.2	0.7	-0.2	0.5	0.4
Medication: Lisinopril	0.3	0.4	1.0	0.2	0.6	0.8	0.4	0.3	0.7	1.0	0.5	-0.5	-0.6
Medication: Atorvastatin	1.0	1.3	2.6	-0.9	-1.6	-1.4	-1.2	-0.9	-1.0	-1.6	0.7	-0.3	-0.9
Illnesses of father: High blood pressure	1.6	2.0	5.3	1.4	2.1	0.9	2.3	1.5	1.4	1.7	0.4	-0.3	-0.3
Alcohol drinker status: Never	1.2	1.4	4.7	0.2	-2.2	-1.4	-0.7	-1.4	-0.1	1.1	1.2	-1.3	-0.9
Ever smoked	0.9	1.5	4.2	-2.0	1.5	-0.8	-0.9	-0.4	-0.7	0.5	-1.3	1.7	1.5
Basal metabolic rate	0.5	2.9	8.0	1.3	1.1	0.9	2.1	1.5	1.5	2.8	-2.3	1.3	1.2
Leg fat percentage (left)	0.1	0.3	2.3	-0.4	0.0	-0.6	-0.1	-0.3	-1.5	0.2	-0.0	0.1	-0.7
Arm fat-free mass (left)	0.5	2.7	7.7	0.5	1.7	0.4	1.6	1.1	1.5	2.8	-2.5	1.5	1.0
Number of operations (self-reported)	0.6	0.9	4.6	-1.7	2.1	-1.0	-0.6	-0.7	0.0	-0.2	0.2	0.1	-0.1
Average weekly beer plus cider intake	0.7	1.0	3.2	0.4	1.4	-0.2	1.2	0.3	1.8	1.5	-0.3	-0.4	-0.8
Irritability	0.8	1.3	3.1	0.6	1.8	1.3	1.3	1.3	0.9	1.5	-0.6	0.7	0.9
Risk taking	0.5	0.7	1.6	-1.1	0.8	-0.4	-1.0	-0.8	-0.6	-1.3	-0.4	0.3	1.0
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.6	0.5	-0.5	-0.6	-0.3	-0.3	-1.1	0.0	1.3	-0.9	-0.8
Fractured/broken bones in last 5 years	1.0	1.3	2.7	-0.9	1.5	0.5	0.6	0.7	0.1	1.6	-1.6	1.2	1.4
Age started oral contraceptive pill	0.9	1.2	3.7	-0.9	-1.6	-0.6	-1.3	-1.2	-1.1	-1.9	0.3	-0.1	0.2
Diastolic blood pressure, automated reading	0.2	0.6	2.6	-0.2	-0.7	-0.5	-0.1	-0.7	-1.6	-0.6	0.6	-0.4	-1.1
Ever depressed for a whole week	0.8	1.0	2.8	0.8	1.7	-0.1	0.1	-0.8	1.4	-0.6	1.2	-0.9	-1.3
Unable to work because of sickness or disability	0.3	0.4	1.2	-0.8	0.8	-1.1	-0.4	-0.3	-0.5	1.0	0.5	-0.0	0.4
Commuting to job workplace: Cycle	0.5	0.6	2.1	-0.2	-0.5	-0.9	-1.4	-1.0	0.2	1.2	0.6	-0.1	-0.3
Myopia	0.3	0.4	0.7	0.4	-0.6	0.7	0.6	0.7	0.7	0.6	0.1	-0.8	-0.7
Vascular/heart problems diagnosed by doctor	0.5	1.4	5.7	1.6	0.8	1.4	1.2	0.6	2.4	0.7	-0.6	-0.3	-0.3
Cholesterol lowering medication	1.1	1.6	3.4	-0.8	-0.4	-1.9	-1.6	-1.2	-0.4	-1.6	1.5	-0.8	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.5	-1.0	-0.6	-1.6	-1.2	-1.0	-0.9	-0.8	0.1	1.0	0.8
Pain experienced in last month	0.8	1.3	4.3	-1.1	-0.3	-2.1	-1.0	-1.7	-0.0	-1.3	0.7	-0.8	-1.1
Supplements: Calcium	0.2	0.2	0.8	-0.3	-0.5	-0.2	-0.4	0.1	-0.1	-0.6	-0.9	0.7	0.6
Basal cell carcinoma (self-reported)	2.3	2.7	7.3	-0.0	-2.0	-0.6	-1.0	-1.5	-1.8	-2.0	2.7	-1.7	-1.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	4.3	-0.9	-0.3	-1.3	-0.5	-0.2	-2.1	0.7	0.8	0.3	-0.4
Deep venous thrombosis (DVT) (self-reported)	4.6	5.9	38.5	-0.9	2.3	-0.1	-0.5	0.6	0.2	6.2	-1.9	2.2	2.4
Heart disease (siblings)	0.5	0.6	1.7	0.0	1.0	0.7	1.3	0.7	-1.2	0.9	-0.1	-0.4	-0.0
Alcohol drinker status: Previous	0.8	0.9	3.0	-1.1	1.7	0.6	0.2	0.5	-0.8	-0.5	-0.3	1.0	1.4
Pack years of smoking	0.9	1.3	3.8	-1.4	-0.1	-2.0	-1.3	-1.8	-0.5	-1.0	0.7	0.4	-0.0
Impedance of whole body	0.3	1.5	4.6	-0.1	-0.3	-0.0	-1.0	-0.7	-0.3	-2.1	2.0	-1.5	-1.5
Leg fat mass (left)	0.2	0.7	2.5	0.7	0.5	0.4	1.3	0.9	-0.4	1.6	-0.9	0.4	-0.0
Arm predicted mass (left)	0.6	3.0	8.0	0.6	1.8	0.6	1.7	1.2	1.7	2.8	-2.6	1.6	1.1