Hub : Genes

SCYL3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0620 0.0250 1.4e-03 0.020 0.027 0.028 0.028 0.040 1.7e-03 2.4e-04 2.0e-04 2.2e-04 1.2e-05
2 GTEx Brain Cerebellum 0.2020 0.0640 5.7e-04 0.122 NA 0.171 NA 0.182 1.9e-04 NA 9.2e-06 NA 4.7e-06
3 GTEx Cells Transformed fibroblasts 0.0860 0.0360 5.8e-03 0.041 NA 0.026 NA 0.026 4.8e-04 NA 4.6e-03 NA 4.4e-03
4 GTEx Colon Sigmoid 0.2310 0.1050 8.1e-03 0.090 NA 0.016 NA 0.027 4.5e-04 NA 8.4e-02 NA 4.0e-02
5 GTEx Esophagus Gastroesophageal Junction 0.1360 0.0550 3.3e-03 0.027 NA 0.047 NA 0.006 3.7e-02 NA 8.2e-03 NA 1.9e-01
6 GTEx Muscle Skeletal 0.0545 0.0209 1.4e-03 0.047 NA 0.043 NA 0.049 2.2e-05 NA 4.2e-05 NA 1.5e-05
7 GTEx Skin Sun Exposed Lower leg 0.0740 0.0330 6.3e-03 0.054 NA 0.027 NA 0.030 2.6e-05 NA 2.5e-03 NA 1.4e-03
8 GTEx Uterus 0.2860 0.0980 2.6e-03 0.157 NA 0.058 NA 0.125 4.4e-04 NA 2.6e-02 NA 1.7e-03
9 YFS Blood 0.0316 0.0093 1.2e-07 0.037 0.026 0.029 0.027 0.034 4.0e-12 4.8e-09 4.9e-10 2.3e-09 2.2e-11
10 TCGA Brain Lower Grade Glioma 0.0499 0.0285 4.1e-04 0.000 0.034 0.019 NA 0.003 2.8e-01 8.8e-05 2.9e-03 NA 1.2e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.2 0.4 0.9 0.7 -0.5 -0.7 0.5 0.0 0.4 -0.3 -0.6 -0.9 0.9
Bipolar Disorder or Schizophrenia 1.0 2.4 6.7 1.3 1.7 -0.5 2.6 0.9 0.9 1.9 1.4 -0.8 2.1
Depressed Affect (Nagel 2018) 0.3 0.7 1.8 -1.3 -0.4 1.4 -0.3 0.8 0.3 0.2 -0.2 1.3 -0.4
Depression (Nagel 2018) 0.2 0.4 1.3 -0.2 -0.3 0.9 -0.7 0.2 0.4 0.0 -1.1 0.8 -0.3
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.9 -1.1 -1.0 0.5 -0.7 0.2 0.0 -1.4 -0.6 0.4 -0.9
Neuroticism (Nagel 2018) 0.2 0.5 1.7 0.2 -0.5 0.4 -1.3 0.5 0.8 0.5 -1.1 0.4 0.6
Schizophrenia (2018) 1.7 3.5 8.5 1.1 2.6 -0.1 2.9 1.1 0.9 2.7 2.3 -0.3 2.0
Schizophrenia vs Biploar Disorder 1.0 1.4 4.0 0.2 0.8 0.3 1.4 1.5 1.4 1.5 0.6 0.1 2.0
Worry (Nagel 2018) 0.4 0.9 2.7 1.6 -0.2 -0.8 -1.3 -0.4 0.3 0.3 -1.7 -0.9 0.9
Alzheimer’s Disease (in mother) 0.2 0.2 1.1 0.1 -0.3 0.3 0.3 0.2 0.7 -0.3 -1.1 0.2 0.3
Alzheimer’s Disease (in father) 0.6 0.6 2.2 -1.5 -0.2 0.9 0.3 0.8 1.0 -0.2 0.3 1.0 -0.4
Alzheimer’s Disease (including proxy) 0.3 0.4 0.8 0.4 -0.6 -0.7 0.6 -0.1 0.9 -0.2 -0.7 -0.7 0.7
Crohns Disease (2017) 1.8 3.9 10.8 -0.5 3.3 1.5 2.1 0.3 -1.4 2.2 3.2 1.9 -1.0
Irritable Bowel Disease (IBD) 2.1 5.0 14.5 -1.3 3.4 1.6 2.4 -0.3 -1.6 1.8 3.8 2.1 -1.9
Ulcerative Colitis (UC) 1.9 3.6 9.9 -1.7 2.7 1.6 1.9 -0.2 -0.8 1.5 3.1 2.0 -1.7
Major Depression (MDD) 2.0 2.4 6.9 -0.9 0.9 1.5 0.7 2.3 2.6 1.8 0.4 1.3 1.5
Reaction Time 0.6 1.2 4.2 2.0 0.0 -1.4 0.4 -0.5 0.3 0.6 -0.7 -1.5 1.5
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.3 -1.5 0.3 1.3 -0.5 0.2 -0.6 -0.2 0.1 1.4 -1.5
Breast Cancer 0.6 1.4 3.4 -1.0 1.7 1.0 1.5 0.8 0.1 1.1 1.9 1.0 -0.3
Ovarian Cancer 0.4 0.5 1.5 -0.1 -0.5 -1.0 0.7 -1.2 -0.6 -0.6 0.5 -0.8 -0.5
Prostate Cancer 0.1 0.2 0.8 -0.1 0.3 0.4 -0.9 -0.3 0.1 -0.3 -0.2 0.4 -0.3
Age at First Birth 0.5 0.7 2.6 -0.5 0.6 0.4 -0.9 -0.9 -1.0 -0.6 0.3 0.6 -1.6
Bipolar Disorder (2011) 0.4 0.4 1.4 0.3 0.2 0.2 0.7 0.8 1.2 0.1 -0.6 0.1 1.1
Body Mass Index (BMI) (2010) 0.3 0.5 1.2 -1.1 0.0 1.1 0.3 0.6 0.5 -0.3 0.1 1.1 -0.6
Coronary Artery Disease (CAD) 0.3 0.3 1.0 0.5 0.5 -0.1 0.8 0.2 0.7 1.0 -0.3 -0.2 0.8
Crohns Disease (2012) 0.7 1.1 1.9 0.6 1.4 0.6 1.4 0.1 -1.4 1.4 1.3 0.9 -0.0
Mean Putamen Volume 1.4 1.6 3.4 1.7 0.5 -1.7 1.2 -1.4 -1.8 0.1 0.6 -1.7 -0.1
Fasting Glucose 1.2 1.5 3.9 -1.6 0.7 1.7 0.9 2.0 0.5 1.1 0.4 1.6 -0.0
HbA1C 0.5 0.6 1.5 -0.5 1.2 1.0 -0.2 -0.0 0.6 0.6 1.0 1.1 -0.3
HDL Cholesterol 0.7 1.1 2.9 1.3 -1.0 -1.6 0.2 -0.7 0.3 -0.7 -0.6 -1.7 1.1
LDL Cholesterol 0.3 0.4 1.8 -0.5 -0.2 0.4 -0.4 1.0 1.3 -0.1 -0.5 0.3 0.7
Lupus 0.3 0.5 1.1 0.8 -0.6 -0.9 0.8 -0.3 -0.2 -0.8 -0.2 -1.0 0.5
Neuroticism (2016) 1.1 1.6 4.2 -1.4 -0.6 2.0 -1.2 0.8 0.6 -0.1 -1.1 2.0 -1.1
Primary Biliary Cirrhosis 0.7 0.9 2.6 0.6 -1.6 -0.7 -0.4 0.5 1.0 -0.6 -1.2 -0.9 1.4
Rheumatoid Arthritis 0.5 0.7 2.2 -0.7 -1.5 0.6 -0.8 -0.0 -0.3 -1.1 -1.1 0.5 -0.6
Schizophrenia (2014) 1.3 2.8 6.1 1.3 1.7 -0.3 2.5 1.3 1.2 2.3 1.5 -0.5 2.5
Triglycerides 1.0 1.7 3.9 -1.1 0.3 2.0 -0.7 1.6 2.0 0.7 -0.1 1.9 0.2
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.4 0.3 -0.6 -0.5 -0.2 0.1 0.1 -0.4 -0.2 -0.6 0.2
Ulcerative Colitis 1.0 1.5 6.1 -0.5 1.9 0.5 1.6 -0.5 -0.6 0.8 2.5 0.8 -0.7
Blood Eosinophil Count 0.7 5.1 13.7 3.7 0.2 -3.2 1.6 -1.1 0.4 1.3 0.6 -3.2 3.2
Blood Platelet Count 0.4 4.6 14.4 3.8 -0.4 -3.2 -0.0 -1.9 -0.2 0.0 -0.9 -3.3 2.2
Blood Red Count 0.1 1.1 4.5 -2.1 -0.2 1.4 0.4 1.5 0.0 0.2 -0.1 1.2 -0.6
Blood White Count 0.5 3.4 10.2 -0.3 3.2 0.5 1.8 -0.4 -2.1 2.4 2.9 0.7 -1.2
Heel T-Score 0.3 2.3 4.9 -0.5 1.4 1.8 -0.7 2.1 2.2 1.8 -0.1 1.7 1.3
BMI 0.1 0.5 2.3 -0.5 -1.5 -0.1 0.1 0.2 -0.6 -0.3 -1.3 -0.3 0.2
Height 0.3 6.1 21.1 -3.1 1.1 2.0 0.7 -1.4 -3.2 -1.1 2.1 2.6 -4.6
Waist Hip Ratio (WHR) 1.1 4.9 10.0 -1.0 -2.4 2.3 -2.8 -0.0 1.4 -2.8 -3.2 2.2 -2.1
Systolic Blood Pressure 0.4 2.0 6.8 -0.8 -1.5 -0.3 -1.8 -1.3 0.0 -2.6 -1.3 -0.1 -1.7
Smoking Status 1.6 3.9 9.9 -2.3 -0.7 2.1 -2.7 -0.6 -0.5 -2.0 -0.7 2.4 -3.1
Allergy or Eczema 1.3 3.4 6.4 1.8 -2.5 -2.1 0.0 -0.0 1.6 -1.2 -2.0 -2.4 2.5
Cardiovascular Disease 0.7 2.4 5.8 0.7 -2.3 -1.4 -1.9 -1.0 -0.5 -2.0 -2.4 -1.5 -0.2
Hypothyroidism (self reported) 0.6 1.3 4.2 0.5 -0.5 0.6 -2.0 0.6 1.9 -0.1 -1.3 0.5 1.2
Respiratory disease 0.3 0.6 1.6 -0.4 -0.8 0.7 0.0 1.2 1.2 -0.0 -0.8 0.5 0.9
Type 2 Diabetes (T2D) (2018) 1.8 3.3 10.0 0.4 -3.2 -0.6 -2.2 -0.7 0.3 -2.6 -3.1 -0.8 -0.1
Lung FEV1/FVC ratio 0.3 1.6 3.2 1.8 0.5 -1.6 1.6 -0.5 -0.2 1.4 0.2 -1.7 1.6
Lung FVC 0.5 2.3 4.7 2.1 -1.4 -2.2 -0.6 -1.4 -0.7 -1.8 -0.8 -2.2 0.7
Neuroticism 0.1 0.3 0.7 -0.2 0.3 0.8 -0.6 0.7 0.4 0.8 -0.2 0.8 -0.0
Chronotype (morning person) 0.3 0.7 2.4 1.2 1.1 -0.4 0.9 -0.0 -0.8 1.6 0.2 -0.5 0.7
Hair Pigment 0.0 0.8 2.3 0.0 -0.1 -0.4 -1.5 -1.0 -1.5 -0.6 -0.3 -0.2 -1.2
Tanning 0.1 1.4 5.2 -1.4 0.7 1.1 -0.8 -0.6 -1.7 0.1 0.2 1.2 -2.3
Hand grip strength (left) 0.2 0.6 1.7 -1.3 -0.1 0.9 0.2 1.2 0.7 0.1 0.6 0.8 0.4
Number of treatments/medications taken 1.3 2.4 8.0 0.5 -2.1 -0.3 -2.5 -0.4 0.7 -1.9 -2.8 -0.4 0.3
Average weekly spirits intake 3.2 4.0 9.2 1.3 -2.4 -1.7 -2.0 -2.9 -0.7 -3.0 -2.2 -1.5 -1.0
Sensitivity / hurt feelings 0.8 1.4 2.8 -0.9 0.9 1.6 0.3 1.7 1.2 1.6 0.1 1.5 0.7
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.8 0.7 -0.2 0.1 -0.7 0.1 0.9 0.5 -0.8 0.0 0.8
Hearing difficulty/problems: Yes 0.3 0.5 2.1 -0.5 -0.2 0.8 -1.4 0.2 0.5 -0.4 -0.7 0.8 -0.6
Relative age of first facial hair 1.2 2.5 6.9 0.7 2.6 -0.2 1.9 0.1 0.2 2.6 2.6 -0.0 0.6
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 2.9 0.6 0.1 -0.3 -1.7 0.2 0.8 0.4 -1.1 -0.2 1.1
Ever used hormone-replacement therapy (HRT) 1.6 2.0 4.6 1.6 -0.9 -1.0 -1.7 0.2 1.5 -0.8 -2.1 -1.3 1.9
Ever had hysterectomy (womb removed) 2.3 2.6 5.1 -1.8 -0.9 1.8 -1.5 1.7 2.2 -1.2 -2.2 1.6 -0.1
Systolic blood pressure, automated reading 0.4 1.2 2.7 0.3 -0.7 -0.8 -1.3 -1.5 -0.8 -1.6 -1.0 -0.7 -1.1
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.3 0.1 -0.3 -0.4 0.3 -0.1 0.4 -0.1 0.4 -0.4 0.5
Angina 1.4 1.8 5.9 2.0 -1.1 -1.5 -0.2 0.1 0.9 0.2 -1.1 -1.7 2.4
Medication for hormone replacement therapy 2.5 2.8 7.8 1.3 -2.0 -1.1 -2.8 -1.0 0.7 -1.7 -2.7 -1.2 0.6
Vitamin and mineral supplements 0.5 0.7 1.4 0.2 -0.6 -0.4 -1.0 -1.2 -1.0 -1.2 -0.5 -0.3 -1.0
Supplements: Zinc 2.3 2.4 9.4 0.3 3.1 0.3 1.6 0.5 -0.6 2.6 2.2 0.5 -0.1
Medication: Co-codamol 1.1 1.3 4.4 0.6 -1.7 -0.9 -0.5 -0.3 0.1 -1.5 -2.1 -1.1 0.7
Medication: Metformin 0.2 0.2 0.7 -0.7 -0.6 0.3 -0.0 0.6 0.9 -0.1 -0.5 0.3 0.3
Diabetes (father) 0.7 0.8 2.2 0.5 -1.5 -0.9 -1.3 -0.3 -0.1 -1.0 -1.2 -1.0 0.4
Diabetes (mother) 0.1 0.2 0.7 -0.4 -0.1 0.1 -0.3 0.0 -0.9 -0.3 -0.6 0.2 -0.7
Severe depression (siblings) 0.4 0.4 2.5 0.0 0.1 0.4 0.5 0.6 1.6 0.3 -0.0 0.4 1.0
Pack years adult smoking proportion 0.1 0.2 0.6 0.6 0.3 -0.5 0.1 -0.2 0.8 -0.4 0.2 -0.5 0.7
Impedance of leg (right) 0.5 2.6 12.0 0.7 -0.5 0.3 -2.6 0.7 3.5 -0.8 -1.7 0.1 1.5
Leg fat-free mass (left) 0.7 3.5 6.9 -2.2 0.8 1.4 2.6 -0.2 -2.6 1.1 2.0 1.7 -2.4
Trunk fat percentage 0.1 0.2 1.3 -0.5 -0.6 0.2 -0.5 0.1 -0.4 0.1 -1.2 0.1 -0.2
Hand grip strength (right) 0.3 0.7 1.4 -0.8 -1.2 0.6 -0.6 1.0 1.1 -0.6 -0.8 0.5 0.8
Townsend deprivation index at recruitment 1.0 1.4 4.7 -2.2 -1.0 1.4 -1.1 0.9 0.8 -1.0 -0.6 1.4 -0.8
Current tobacco smoking 0.2 0.3 1.1 -0.4 1.0 -0.0 0.2 -0.5 0.0 0.1 1.0 0.1 -0.6
Average weekly fortified wine intake 0.1 0.2 0.7 -0.0 0.1 -0.3 0.9 -0.4 0.1 -0.3 0.6 -0.3 -0.2
Maternal smoking around birth 1.5 2.2 4.0 -1.3 -1.2 1.5 -1.9 -0.0 1.4 -2.0 -1.7 1.6 -1.3
Fed-up feelings 0.4 0.8 2.3 -1.3 0.2 1.5 -0.4 0.5 -0.0 0.7 -0.4 1.5 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.4 0.3 -0.0 0.2 -0.6 -0.5 -0.4 0.0 -0.5 0.2 -0.3
Relative age voice broke 1.3 2.0 5.7 0.6 1.2 -0.1 1.4 1.4 1.5 2.2 1.2 -0.2 2.4
Taking other prescription medications 1.4 2.1 6.2 -0.3 -2.1 0.0 -2.5 -0.4 0.7 -2.2 -2.1 -0.0 -0.4
Age when periods started (menarche) 0.9 2.2 5.7 2.2 0.3 -2.4 0.5 -1.3 -1.4 -0.0 1.1 -2.3 0.9
Bilateral oophorectomy (both ovaries removed) 2.3 2.7 6.3 -2.0 0.3 2.5 -1.1 2.2 1.9 -0.4 -0.8 2.4 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 5.3 -1.1 0.0 1.6 -0.0 2.3 2.0 1.1 -1.0 1.3 1.0
Tinnitus: Yes, but not now, but have in the past 1.0 1.0 2.7 -1.2 -0.4 1.2 -0.5 1.3 1.6 0.2 -1.0 1.1 0.5
Qualifications: CSEs or equivalent 1.7 2.2 4.4 -2.1 1.1 2.1 1.1 1.5 0.7 1.7 1.2 2.0 -0.4
Serious illness, injury or assault to yourself 0.9 1.1 4.3 1.1 0.3 -1.1 -1.3 -2.1 -0.5 -0.9 0.7 -0.8 -0.9
High blood pressure 0.9 2.4 4.6 0.7 -1.6 -1.6 -1.9 -1.9 -0.8 -2.1 -1.7 -1.6 -0.8
Hayfever, allergic rhinitis or eczema 0.9 1.9 5.1 1.6 -1.2 -2.1 1.3 -0.6 0.5 -0.7 -0.3 -2.2 1.5
Multivitamins +/- minerals 0.1 0.1 0.3 -0.2 0.0 0.0 0.3 0.5 0.6 0.3 0.0 -0.0 0.5
Stomach or abdominal pain in last month 0.6 0.7 1.7 0.8 0.7 -1.3 0.5 -1.2 -0.8 -0.2 0.7 -1.2 -0.4
Supplements: Glucosamine 0.1 0.1 0.6 -0.2 -0.0 -0.3 0.8 -0.0 -0.7 -0.0 0.4 -0.3 -0.1
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 2.4 -0.6 1.5 1.1 0.1 1.0 0.8 1.5 0.4 1.2 0.1
Medication: Atenolol 1.8 2.3 4.2 0.7 -1.6 -1.3 -1.7 -2.1 -1.0 -2.0 -1.7 -1.2 -1.3
Medication: Levothyroxine sodium 0.9 1.4 4.6 1.5 -0.8 -0.5 -2.1 -0.9 0.9 -1.3 -1.7 -0.5 0.5
Sitting height 0.2 1.4 4.2 -2.1 -0.3 1.5 1.8 0.9 0.0 0.0 1.0 1.4 -0.6
Chronic bronchitis/emphysema (father) 0.7 0.8 2.7 -0.1 -0.5 0.4 -0.5 1.3 1.6 0.0 -1.6 0.2 0.9
High blood pressure (mother) 1.2 1.6 3.3 1.8 0.0 -1.8 0.4 -1.7 -1.8 -0.0 0.4 -1.7 -0.2
Body mass index (BMI) 0.2 0.8 2.3 -1.4 -0.6 0.5 0.5 -0.2 -1.5 -0.0 -0.5 0.7 -1.5
Impedance of leg (left) 0.5 2.4 12.5 0.6 0.1 0.5 -1.9 1.4 3.5 -0.2 -1.1 0.3 2.1
Leg predicted mass (left) 0.7 3.5 7.3 -2.1 0.9 1.4 2.7 -0.2 -2.6 1.3 2.0 1.6 -2.2
Trunk fat mass 0.1 0.5 1.1 -1.0 -0.6 0.5 -0.1 -0.0 -1.0 -0.0 -0.8 0.6 -0.9
Waist circumference 0.5 1.7 4.4 -2.0 -0.9 1.7 -0.2 0.1 -0.7 -0.7 -1.1 1.7 -2.1
Number of incorrect matches in round 1.2 2.0 4.6 -0.3 -1.0 0.0 -2.0 -1.8 -0.5 -2.0 -1.5 0.3 -2.2
Past tobacco smoking 2.6 4.7 10.7 2.4 1.8 -2.3 3.3 0.3 -0.2 2.3 1.8 -2.5 2.7
Alcohol usually taken with meals 0.4 0.6 1.7 0.8 -0.6 -0.8 -1.3 -0.9 -0.8 -0.6 -0.8 -0.8 -0.2
Nervous feelings 0.3 0.5 2.3 0.9 0.7 -0.4 -1.5 -0.2 0.4 0.9 -0.6 -0.3 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.4 -0.0 0.3 0.6 -0.1 0.5 1.2 0.4 -0.6 0.5 0.8
Hearing difficulty/problems with background noise 0.4 0.7 2.2 -1.0 -0.3 0.5 -0.9 -0.5 -0.8 -1.0 -0.2 0.6 -1.5
Hair/balding pattern: Pattern 2 1.9 2.4 6.1 -1.3 1.6 0.5 1.7 -0.1 -2.0 1.8 2.5 0.8 -1.3
Had menopause 0.4 0.6 1.1 0.1 -0.9 -0.3 -0.9 0.6 1.0 -0.6 -1.0 -0.6 0.9
Had other major operations 0.4 0.5 1.8 1.1 0.2 -0.6 1.4 -0.2 0.3 0.2 0.9 -0.6 0.7
Forced vital capacity (FVC) 0.2 0.9 4.6 -0.5 0.5 0.5 2.1 0.6 -0.2 0.6 1.6 0.5 0.3
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.4 8.0 -1.0 0.5 1.5 0.6 2.8 2.3 1.4 -0.5 1.2 1.7
Ever unenthusiastic/disinterested for a whole week 1.2 1.4 2.8 -0.1 1.4 1.2 0.4 1.5 1.6 1.7 0.6 1.1 1.1
Qualifications: None of the above 1.8 3.9 11.4 -1.5 -3.4 0.2 -2.4 -0.5 -0.2 -3.3 -2.6 0.1 -1.2
Financial difficulties in last 2 years 0.3 0.4 0.7 -0.8 0.4 0.7 0.6 0.8 -0.5 0.5 0.4 0.6 -0.3
Mouth/teeth dental problems 1.6 2.4 4.4 1.2 -1.8 -2.1 -0.7 -2.0 -1.0 -1.9 -1.4 -2.0 -0.1
Heart attack 3.2 4.1 10.4 0.8 -2.7 -0.8 -3.1 -2.1 -0.5 -2.5 -3.2 -0.7 -1.2
Allergy 0.5 1.2 2.2 -1.2 1.3 1.4 -0.5 0.1 -1.1 0.5 0.7 1.5 -1.4
Pain all over the body in last month 0.6 0.6 1.7 0.9 -0.2 -1.0 -1.1 -1.3 -0.7 -0.5 -0.7 -0.8 -0.4
Diabetes (self-reported) 0.7 1.0 4.3 -0.8 -2.1 -0.1 -0.8 0.1 0.7 -1.5 -1.4 -0.2 -0.1
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 1.0 0.2 -1.0 0.0 -0.4 0.5 0.5 -0.4 -0.6 -0.0 0.3
Medication: Ramipril 2.1 2.6 5.5 0.4 -2.0 -1.1 -1.6 -1.6 -2.3 -2.0 -1.6 -1.1 -1.5
Medication: Simvastatin 0.8 1.2 3.1 0.3 -1.6 -0.7 -1.8 -0.5 -0.2 -1.5 -1.5 -0.7 -0.3
Fluid intelligence score 0.4 0.9 2.6 -1.5 0.4 1.6 -0.6 0.6 0.1 -0.1 0.0 1.6 -0.8
Illnesses of siblings 1.7 2.4 4.2 -0.5 2.1 0.9 1.9 1.6 1.7 2.0 1.9 0.8 1.1
Neuroticism score 1.0 2.1 4.9 -1.4 1.1 2.2 -0.2 1.8 1.3 1.7 0.1 2.2 0.2
Weight 0.4 1.8 4.4 -2.1 0.1 1.4 1.3 0.1 -1.8 0.5 0.6 1.5 -1.9
Impedance of arm (right) 0.3 1.2 5.0 2.2 0.8 -0.9 -1.1 -0.3 0.8 0.9 -0.2 -1.1 1.3
Arm fat percentage (right) 0.1 0.4 1.4 -0.3 -0.8 0.0 -0.2 -0.4 -1.1 -0.0 -1.2 -0.0 -0.8
Trunk fat-free mass 0.6 3.3 6.4 -2.5 0.7 1.8 2.5 0.2 -2.0 0.6 2.0 2.0 -2.2
Hip circumference 0.3 1.4 4.1 -1.4 0.7 0.5 1.7 -0.0 -2.0 1.1 1.2 0.6 -1.2
Time employed in main current job 2.8 3.2 6.3 1.6 -2.5 -2.4 -0.2 -1.4 -0.5 -2.3 -1.7 -2.5 0.8
Alcohol intake versus 10 years previously 1.2 1.7 4.9 -1.8 0.2 1.7 -0.8 0.1 -1.2 -0.7 0.2 1.9 -2.2
Father’s age at death 1.6 2.2 7.9 2.8 -0.4 -2.1 0.1 -1.4 0.0 0.1 -0.9 -2.1 1.4
Worrier / anxious feelings 0.6 1.1 4.8 0.2 1.0 0.8 0.1 1.5 1.0 2.2 0.1 0.7 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 1.4 0.6 0.8 -0.2 1.2 -0.4 -0.7 0.9 0.6 -0.2 -0.2
Falls in the last year 1.1 1.5 3.2 -1.6 -0.8 1.8 -1.2 0.9 1.3 -0.5 -1.2 1.8 -0.5
Hair/balding pattern: Pattern 3 1.3 1.9 4.7 2.0 0.2 -2.0 1.7 -0.3 0.3 0.1 0.4 -2.2 1.7
Number of live births 0.4 0.5 1.2 0.3 0.2 -0.4 0.8 0.7 1.1 0.6 0.9 -0.4 1.1
Forced expiratory volume in 1-second (FEV1) 0.7 2.2 10.1 0.1 1.4 0.1 3.2 0.8 -0.5 2.0 2.1 0.1 1.0
Pulse rate 0.8 1.3 2.2 1.2 -1.4 -1.4 -1.2 -0.5 0.6 -0.9 -1.3 -1.5 1.2
Happiness 2.5 3.1 6.5 2.3 0.9 -2.1 2.2 -0.3 0.7 1.2 1.2 -2.4 2.5
Noisy workplace 1.9 2.3 9.6 1.0 0.8 -1.0 -0.1 -2.1 -3.1 -0.0 1.4 -0.6 -2.0
Qualifications: A levels/AS levels or equivalent 0.3 0.7 3.0 1.0 -0.0 -0.5 0.8 0.6 0.8 0.6 -0.3 -0.7 1.7
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.7 0.8 0.2 -0.6 -0.3 -0.4 0.5 0.0 -0.3 -0.4 0.5
Mouth/teeth dental problems: Dentures 0.1 0.2 0.6 0.8 -0.1 -0.3 -0.5 0.5 -0.0 0.1 -0.4 -0.5 0.7
Asthma 0.7 1.3 4.0 -0.3 0.1 0.8 1.0 2.0 1.6 1.2 -0.4 0.6 1.6
Medication: Ibuprofen (e.g. Nurofen) 2.1 2.7 5.4 -1.3 2.3 2.0 0.9 1.0 -0.1 1.6 2.3 2.2 -1.1
Medication: Cholesterol lowering 1.3 1.9 4.3 0.1 -2.1 -1.0 -1.7 -1.1 -1.4 -1.8 -1.8 -0.9 -1.0
Depression (self-reported) 0.8 0.9 1.7 -1.0 1.1 1.2 0.9 0.8 -0.4 1.3 0.8 1.2 -0.4
Medication: Lansoprazole 0.8 0.9 2.3 0.8 -1.4 -0.9 -0.4 -0.6 -0.2 -1.3 -1.5 -0.9 0.2
Prospective memory result 0.8 1.0 3.2 -0.4 -0.2 -0.6 -0.2 -1.4 -1.6 -1.4 -0.2 -0.3 -1.8
Lung cancer (father) 0.7 0.8 2.7 -1.6 -0.4 1.3 -0.5 1.0 0.5 -0.5 -0.5 1.2 -0.7
Illnesses of mother 0.5 0.6 1.3 -1.0 0.5 1.0 -0.0 1.1 0.8 1.0 0.6 0.9 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.4 10.6 -0.6 2.2 0.9 3.3 0.8 -0.8 2.4 3.0 1.0 0.1
Pulse wave Arterial Stiffness index 1.6 1.9 4.7 0.4 -0.3 -1.4 -1.5 -2.2 -1.9 -1.4 -0.6 -1.2 -1.6
Impedance of arm (left) 0.2 1.0 3.5 1.9 0.8 -0.7 -1.4 -0.1 0.6 0.9 -0.3 -0.9 1.1
Arm fat mass (right) 0.2 0.7 2.0 -1.1 -0.2 0.6 0.6 -0.2 -1.4 0.3 -0.2 0.7 -1.3
Trunk predicted mass 0.6 3.4 6.6 -2.5 0.8 1.9 2.6 0.3 -1.9 0.8 2.0 2.1 -2.1
Standing height 0.2 2.4 6.0 -1.5 1.5 1.6 2.0 0.4 -1.1 1.1 2.5 1.7 -1.1
Length of working week for main job 0.2 0.2 0.9 -0.1 0.4 0.3 0.7 0.4 -0.9 0.7 0.2 0.2 -0.1
Exposure to tobacco smoke at home 0.5 0.5 1.8 -0.7 -0.8 0.4 -0.3 -0.3 0.6 -1.4 -1.0 0.4 -0.7
Breastfed as a baby 0.3 0.4 1.2 -0.5 0.3 -0.3 -1.1 -0.6 0.3 -1.0 0.4 -0.2 -0.7
Tense / ‘highly strung’ 2.0 3.3 13.9 1.6 0.1 -0.4 0.3 1.9 3.0 1.4 -0.8 -0.8 3.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.6 2.4 6.8 -0.0 0.8 0.9 0.6 2.4 2.6 1.9 -0.0 0.6 2.5
Hair/balding pattern: Pattern 4 4.6 11.2 27.6 -1.9 -4.1 2.5 -3.9 1.7 4.6 -3.8 -5.2 2.1 0.2
Birth weight of first child 0.5 0.8 2.0 -1.1 0.2 1.4 0.9 0.8 0.9 0.2 1.0 1.4 0.1
Peak expiratory flow (PEF) 1.6 3.6 7.6 -1.6 2.0 1.5 2.4 1.9 0.1 2.8 2.6 1.6 0.4
Pulse wave reflection index 0.7 0.8 2.8 0.3 -0.0 -1.0 -0.5 -1.3 -1.7 -0.7 -0.0 -0.9 -1.0
Ever highly irritable/argumentative for 2 days 0.8 1.0 2.3 1.5 0.8 -1.4 0.3 -1.1 -0.9 0.3 0.9 -1.3 0.4
Loud music exposure frequency 0.4 0.5 1.3 0.3 0.4 0.5 -0.3 1.0 0.8 1.2 -0.4 0.4 0.9
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.0 -0.0 1.4 0.3 1.4 0.2 -0.1 1.1 1.4 0.4 -0.2
Mouth/teeth dental problems: Bleeding gums 1.5 1.9 4.2 -0.6 1.6 1.4 1.2 2.0 1.5 1.5 1.1 1.2 1.1
Blood clot in the leg (DVT) 1.5 1.9 4.0 -1.5 1.2 1.6 0.2 0.8 -0.1 2.0 1.9 1.8 -1.0
Medication: Paracetamol 0.1 0.2 0.8 -0.4 -0.2 0.2 0.9 -0.2 -0.7 -0.2 0.1 0.3 -0.5
Headache pain in last month 0.2 0.3 0.9 0.7 -0.4 -0.8 0.1 -0.3 -0.6 -0.3 -0.3 -0.9 0.3
Medication for cholesterol, blood pressure or diabetes 3.9 6.5 11.9 -1.4 3.5 2.6 2.7 2.5 1.7 3.4 3.0 2.6 0.8
Glaucoma (self-reported) 0.6 0.7 2.5 0.5 -1.6 -0.9 -0.3 -0.1 0.3 -1.2 -0.7 -1.1 0.6
Gout (self-reported) 1.5 2.1 5.7 -0.1 -1.6 -0.8 -2.3 -1.4 -0.8 -2.4 -1.3 -0.7 -1.4
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 3.5 1.0 -0.6 0.2 -1.9 -0.1 1.3 -0.5 -1.4 0.1 1.0
Medication: Amlodipine 0.2 0.3 0.7 -0.1 -0.8 -0.5 -0.5 -0.7 -0.1 -0.8 -0.4 -0.5 -0.2
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.3 -0.6 0.1 0.9 0.8 1.1 0.1 0.5 0.1 0.8 0.4
Birth weight 0.5 1.2 4.1 -0.3 -0.7 -0.9 -0.0 -1.6 -2.0 -1.1 0.2 -0.7 -1.3
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.3 -0.8 0.3 1.1 -0.3 0.9 0.5 0.3 -0.0 1.1 -0.1
High blood pressure (siblings) 1.5 2.2 4.5 0.5 -2.1 -0.6 -1.5 -1.2 -1.7 -2.1 -2.0 -0.7 -0.9
Forced vital capacity (FVC), Best measure 0.7 2.5 7.6 -1.0 1.6 1.3 2.8 1.0 -0.4 1.6 2.6 1.4 0.0
Body fat percentage 0.1 0.4 1.8 -0.8 -0.9 0.4 -0.6 0.1 -0.4 -0.3 -1.3 0.3 -0.6
Leg fat percentage (right) 0.3 1.1 2.9 -1.0 -1.3 0.3 -1.4 -0.5 0.0 -1.2 -1.7 0.4 -1.1
Arm fat-free mass (right) 0.7 3.5 10.2 -3.2 0.3 2.3 2.2 1.1 -1.0 0.6 1.5 2.5 -1.7
Exposure to tobacco smoke outside home 0.1 0.2 0.6 -0.3 -0.1 0.4 -0.2 -0.8 0.5 0.0 0.0 0.5 -0.6
Comparative body size at age 10 0.4 1.1 2.2 -1.5 0.6 1.3 1.2 0.3 -1.3 0.6 0.5 1.4 -1.3
Number of full brothers 0.3 0.4 1.6 0.8 0.4 -0.3 -0.6 -0.5 -1.2 0.5 -0.1 -0.3 -0.4
Worry too long after embarrassment 0.6 1.0 2.5 -0.5 0.9 1.2 0.2 1.3 0.9 1.6 0.7 1.2 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.1 4.0 0.8 0.8 -0.8 0.9 0.9 0.6 1.5 0.3 -0.9 2.0
Wheeze or whistling in the chest in last year 0.5 0.8 2.8 -0.6 -1.7 -0.1 -0.9 -0.3 0.6 -1.5 -1.2 0.0 -0.4
Number of children fathered 0.6 0.6 1.4 -1.1 -0.9 0.7 -0.5 0.6 0.6 -1.2 -0.8 0.6 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.8 -0.2 -0.8 -0.1 -1.1 -0.8 -0.4 -1.3 -0.9 -0.1 -1.0
Age at first live birth 0.5 0.9 3.4 0.5 0.8 0.3 0.9 1.1 1.1 1.9 0.5 0.0 1.2
Pulse wave peak to peak time 1.9 2.2 5.6 -0.7 0.4 1.7 1.6 2.4 1.9 1.5 0.7 1.5 1.4
Health satisfaction 0.4 0.6 1.8 1.3 0.3 -1.0 0.6 -0.5 -0.1 0.6 0.4 -1.0 0.7
Shortness of breath walking on level ground 1.3 1.5 4.7 1.1 -0.8 -1.5 -1.2 -2.2 -1.0 -1.0 -1.0 -1.3 -0.7
Qualifications: College or University degree 0.7 2.2 8.5 0.3 0.6 0.1 1.6 2.2 1.9 1.5 0.6 -0.1 2.9
Eye problems/disorders: None of the above 1.3 1.5 3.2 -1.8 0.9 1.7 0.5 1.0 -0.4 1.1 1.0 1.7 -1.0
Mouth/teeth dental problems: Loose teeth 1.0 1.2 3.5 -0.8 0.1 1.4 -1.1 1.5 1.9 0.1 -0.4 1.4 0.7
Emphysema/chronic bronchitis 0.9 1.0 2.2 -0.0 -1.5 -0.4 -0.7 0.3 1.3 -1.4 -1.4 -0.5 0.9
Medication for pain relief, constipation, heartburn 0.2 0.4 1.1 0.9 0.0 -1.0 0.4 -0.5 0.2 0.1 0.1 -1.0 0.7
Neck or shoulder pain in last month 0.9 1.2 3.3 -0.3 1.6 1.0 0.8 1.3 0.5 1.8 0.9 1.0 0.9
Medication: Blood pressure 4.2 7.5 11.8 1.7 -3.1 -3.0 -2.7 -3.4 -2.6 -3.2 -2.5 -2.9 -1.4
Angina (self-reported) 1.8 2.4 7.1 2.3 -1.2 -1.8 -0.3 -0.0 1.0 0.0 -1.4 -1.9 2.7
Migraine (self-reported) 0.3 0.3 1.7 -0.4 -1.3 -0.0 -0.1 -0.2 -0.5 -0.9 -0.2 -0.0 -0.6
Medication: Ibuprofen 1.7 2.1 4.4 -1.2 1.9 1.9 0.9 0.9 0.2 1.3 2.1 2.0 -1.0
Medication: Allopurinol 2.5 3.3 10.2 0.0 -2.8 -0.6 -2.4 -1.6 -0.2 -3.2 -2.3 -0.6 -1.2
Medication: Omeprazole 0.4 0.5 1.4 1.2 -0.4 -1.0 -0.4 -0.7 -0.2 -0.2 -0.7 -1.0 0.7
Medication: Seretide 50 evohaler 1.7 2.0 6.9 0.8 -2.0 -0.8 -1.9 -0.5 0.3 -1.7 -2.6 -0.9 0.4
Mean time to correctly identify matches 1.1 2.0 4.6 2.1 -0.8 -2.1 -0.8 -1.5 -0.5 -0.8 -1.4 -2.1 0.7
Heart disease (mother) 0.1 0.2 0.5 -0.2 0.4 0.5 0.4 0.4 0.7 -0.1 0.4 0.5 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 2.0 -1.0 1.3 1.0 0.8 1.0 -0.1 1.1 1.4 1.0 -0.2
Whole body fat mass 0.2 0.7 1.9 -1.4 -0.5 0.8 0.2 -0.0 -1.2 0.0 -0.5 0.8 -1.3
Leg fat mass (right) 0.3 1.2 3.7 -1.9 -0.6 1.0 0.0 -0.2 -1.1 -0.4 -0.5 1.2 -1.9
Arm predicted mass (right) 0.8 4.2 10.4 -3.2 0.8 2.2 2.6 0.8 -1.6 0.9 2.0 2.5 -2.1
Pulse rate, automated reading 1.0 3.4 7.8 2.0 -2.3 -2.1 -1.1 -1.3 0.2 -2.1 -2.8 -2.2 0.9
Alcohol intake frequency. 0.1 0.3 1.9 -0.2 -0.1 -0.4 -0.5 -0.4 -1.4 -0.0 -0.0 -0.3 -0.7
Comparative height size at age 10 0.4 2.3 6.9 -2.6 0.0 2.3 0.4 0.6 -0.5 -0.1 1.0 2.3 -2.0
Number of full sisters 0.6 0.8 2.7 -1.0 0.5 0.7 -0.6 -0.3 -1.4 -0.1 0.3 0.9 -1.6
Suffer from ‘nerves’ 1.9 3.0 5.3 2.3 -1.3 -2.2 -1.5 -2.1 -1.0 -0.9 -2.2 -2.2 0.0
Overall health rating 0.2 0.5 1.7 0.2 -0.9 0.1 -1.0 -0.4 0.8 -0.4 -1.3 0.0 -0.1
Chest pain or discomfort 0.3 0.4 1.0 0.9 -0.0 -1.0 0.8 -0.6 0.3 -0.1 -0.2 -1.0 0.7
Had major operations 0.8 0.9 2.4 -0.7 -0.6 0.9 -1.2 0.8 1.6 -0.6 -1.5 0.8 -0.0
Age at last live birth 0.2 0.3 1.1 0.3 0.6 0.5 0.5 0.8 0.4 1.1 0.3 0.3 0.4
Family relationship satisfaction 4.0 4.9 11.6 -0.4 2.9 0.9 3.4 1.6 0.9 3.4 3.3 0.9 1.3
Leg pain on walking 0.4 0.5 1.6 -0.3 0.2 0.3 -0.9 -1.3 -0.8 -0.4 0.1 0.6 -1.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 0.9 0.0 0.8 0.0 -0.1 -0.8 -0.7 0.7 1.0 0.2 -1.0
Commuting to job workplace: Car/motor vehicle 1.3 1.5 3.3 0.8 -1.0 -1.0 -1.4 -1.7 -1.8 -1.3 -0.7 -0.9 -1.2
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 3.1 -1.3 0.6 1.1 1.8 1.6 0.4 0.9 1.1 0.9 0.2
Medication: Aspirin 0.7 1.0 3.9 -0.4 -1.1 0.8 -2.0 0.5 0.8 -0.7 -1.4 0.7 -0.2
Supplements: Vitamin C 1.0 1.2 2.5 -0.4 1.5 0.7 1.3 1.3 0.7 1.6 1.4 0.7 0.7
Knee pain experienced in last month 0.4 0.6 1.7 0.5 -0.5 -0.8 -0.7 -1.3 -0.6 -0.7 -0.6 -0.7 -0.7
Hypertension (Self-reported) 1.0 2.8 5.2 0.7 -1.6 -1.6 -2.0 -2.2 -1.2 -2.3 -1.6 -1.5 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.4 2.8 11.8 1.1 -0.8 -0.6 2.1 1.8 1.6 1.0 -1.1 -1.1 3.4
Illnesses of father: Heart disease 0.7 0.9 2.3 1.5 -0.8 -1.1 -0.1 -0.3 0.0 -0.7 -1.3 -1.2 1.0
Illnesses of siblings: Diabetes 0.7 0.8 1.8 0.7 -1.0 -0.7 -1.1 -1.2 -0.6 -1.4 -1.0 -0.6 -0.5
Smoking status: Previous 3.2 4.7 8.9 -2.5 -1.7 2.6 -3.0 0.1 -0.2 -2.0 -1.7 2.7 -2.8
Forced expiratory volume in 1-second (FEV1), predicted 2.0 4.1 9.8 -0.7 2.7 1.3 2.8 1.1 -1.0 3.1 3.1 1.4 -0.1
Whole body fat-free mass 0.6 3.7 7.9 -2.5 0.8 1.8 2.8 0.3 -2.1 1.0 2.1 2.0 -2.1
Leg fat-free mass (right) 0.8 4.5 11.0 -2.3 1.3 1.7 3.3 0.4 -2.6 1.7 2.5 1.9 -2.0
Arm fat percentage (left) 0.1 0.5 1.9 -0.6 -0.6 0.3 -0.3 -0.2 -1.4 0.2 -1.0 0.3 -1.0
Average weekly red wine intake 0.8 1.2 3.7 1.4 1.4 -0.7 0.1 -0.5 -1.1 1.9 1.2 -0.6 0.5
Handedness (chirality/laterality): Left-handed 1.3 1.5 3.3 0.6 1.6 0.6 1.6 1.1 1.3 1.8 0.8 0.5 1.6
Mood swings 1.0 1.8 3.3 -1.8 0.9 1.8 0.9 1.5 0.5 1.6 1.3 1.8 -0.1
Loneliness, isolation 1.0 1.4 2.4 -1.4 -0.8 1.5 -1.6 1.2 1.3 -0.1 -1.2 1.5 -0.0
Long-standing illness, disability or infirmity 0.9 1.3 4.9 -0.6 -0.9 0.9 -2.2 0.1 0.8 -1.0 -1.9 1.0 -0.3
Ever had bowel cancer screening 1.8 2.1 5.0 2.2 1.3 -1.7 1.4 -1.3 -1.5 0.9 1.6 -1.6 0.3
Diabetes diagnosed by doctor 0.7 1.1 3.8 -0.3 -2.0 -0.4 -1.2 -0.8 -0.2 -1.6 -1.3 -0.3 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 2.7 0.6 0.1 -0.6 -1.1 -1.6 -1.5 -0.6 0.2 -0.3 -1.3
Friendships satisfaction 0.9 1.1 3.7 1.0 1.0 -0.5 1.2 0.8 -0.0 1.9 0.6 -0.7 1.4
Qualifications: nursing, teaching 0.8 1.3 2.6 1.1 -1.6 -0.8 -0.2 0.3 1.4 -0.6 -1.6 -1.0 1.6
Commuting to job workplace: Walk 1.0 1.1 3.8 0.8 0.3 -0.4 1.7 0.7 0.9 1.3 -0.1 -0.5 2.0
Eye problems/disorders: Cataract 0.6 0.7 1.8 1.4 -0.1 -1.0 -0.1 -0.6 0.7 -0.4 -0.8 -1.1 0.9
Mouth/teeth dental problems: Mouth ulcers 2.9 4.6 11.0 -1.6 2.8 2.0 2.6 1.1 -0.4 2.5 3.3 2.2 -1.1
Medication for cholesterol 0.5 0.7 2.0 -0.9 0.5 0.9 1.4 0.9 -0.2 0.8 1.2 0.8 -0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 1.3 1.1 -0.4 -0.9 0.2 -0.8 -0.8 0.2 0.1 -0.9 0.3
Back pain experienced in last month 1.4 2.0 4.3 -1.1 2.1 1.8 0.5 1.1 0.1 1.9 1.4 1.8 -0.7
Mineral and other dietary supplements 0.1 0.1 0.3 0.1 0.3 0.3 0.0 0.2 -0.5 0.6 0.1 0.3 -0.0
Breast cancer (self-reported) 1.5 1.8 3.0 1.6 -1.6 -1.4 -1.7 -1.0 0.4 -1.4 -1.3 -1.5 0.7
Asthma (self-reported) 0.6 1.3 3.9 -0.5 0.2 1.0 1.0 2.0 1.6 1.2 -0.1 0.8 1.4
Osteoporosis (self-reported) 0.9 1.2 2.4 1.2 0.8 -1.0 1.4 0.3 -0.0 1.6 0.6 -1.1 1.6
Osteoarthritis (self-reported) 0.7 0.9 1.5 0.2 -0.8 -0.5 -1.1 -1.2 -1.0 -1.2 -1.2 -0.4 -1.1
Medication: Aspirin 1.3 1.7 5.8 -0.8 -1.5 1.1 -2.4 0.6 0.7 -1.1 -2.1 1.0 -0.5
Medication: Gliclazide 0.6 0.6 2.2 -0.6 -0.4 0.1 -0.9 -1.0 -0.7 -1.1 -0.1 0.3 -1.5
Illnesses of father: None of the above (group 1) 1.0 1.3 4.6 0.9 -0.1 -1.4 1.3 0.3 0.9 0.5 0.5 -1.5 2.1
Smoking status: Current 0.2 0.2 0.9 -0.1 0.9 -0.2 0.0 -0.7 0.0 0.1 0.8 -0.1 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 4.0 0.4 1.4 0.1 2.0 0.7 0.1 1.6 1.3 0.1 0.9
Whole body water mass 0.6 3.6 7.6 -2.5 0.8 1.8 2.8 0.3 -2.1 1.0 2.0 2.1 -2.1
Leg predicted mass (right) 0.8 4.5 11.3 -2.2 1.4 1.6 3.4 0.3 -2.7 1.8 2.6 1.8 -2.0
Arm fat mass (left) 0.2 0.9 2.4 -1.4 -0.3 0.8 0.5 0.0 -1.5 0.3 -0.3 0.9 -1.5
Number of self-reported non-cancer illnesses 0.4 0.7 2.8 -0.0 -0.9 0.0 -1.7 -0.5 0.6 -1.0 -1.2 0.1 -0.2
Average weekly champagne plus white wine intake 1.2 1.7 3.6 1.9 -1.2 -1.8 -0.0 -1.2 0.3 -1.4 -0.6 -1.9 0.8
Miserableness 1.2 2.0 6.7 -2.6 0.2 2.1 0.5 1.1 -0.4 0.2 0.8 2.2 -1.4
Guilty feelings 2.5 3.8 8.6 -1.4 2.0 1.9 1.3 2.3 2.2 2.9 1.7 1.9 1.2
Wears glasses or contact lenses 0.9 1.1 2.2 1.5 -0.7 -1.2 -1.3 -1.0 -0.2 -0.8 -1.3 -1.2 0.4
Ever taken oral contraceptive pill 0.2 0.3 0.7 0.8 0.4 -0.7 0.0 -0.8 0.0 0.0 -0.2 -0.7 0.3
Hearing aid user 3.0 3.4 8.3 0.5 -2.9 -1.2 -2.4 -1.5 -0.1 -2.8 -2.5 -1.2 -0.7
Mother’s age at death 0.3 0.4 0.9 0.9 0.9 -0.3 -0.5 -0.8 -0.5 0.5 0.9 -0.2 -0.2
Financial situation satisfaction 0.5 0.6 2.2 1.5 -0.0 -0.9 -0.3 -1.1 -0.9 0.3 -0.2 -0.9 0.2
Tinnitus: Yes, now most or all of the time 0.7 0.9 2.0 -0.9 -0.9 0.8 -1.4 0.8 -0.8 -0.2 -1.4 0.6 -0.9
Commuting to job workplace: Public transport 1.6 1.9 5.4 2.3 0.8 -2.0 0.0 -0.5 -0.4 1.0 0.1 -2.1 1.8
Eye problems/disorders: Glaucoma 0.3 0.4 0.9 0.7 -0.6 -0.8 0.6 0.1 0.6 -0.5 0.2 -0.9 0.8
Medication: Blood pressure 0.4 0.8 2.5 -0.0 -0.1 -0.5 -0.6 -1.5 -1.2 -0.8 0.2 -0.2 -1.6
Pain type(s) experienced in last month: Hip pain 0.8 1.0 3.5 0.9 1.9 -0.6 1.0 -0.6 -0.5 0.8 1.6 -0.5 0.2
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.1 1.0 -0.4 -1.0 0.4 -0.4 0.4 -0.3 -0.4 -1.1 0.7
High cholesterol (Self-reported) 1.4 2.5 5.2 2.3 -1.4 -2.2 -1.5 -1.3 -0.8 -0.6 -1.6 -2.2 0.9
Medication: Bendroflumethiazide 1.1 1.7 4.5 -0.7 -1.8 0.0 -1.7 -1.1 -1.0 -2.1 -1.0 0.2 -1.5
Medication: Paracetamol 0.3 0.5 1.3 -0.3 -0.9 0.0 0.1 -0.8 -0.9 -1.1 -0.8 0.2 -1.0
Medication: Lisinopril 0.3 0.4 1.4 -0.4 0.1 0.2 0.8 1.2 0.8 0.9 0.3 0.2 0.8
Medication: Atorvastatin 0.5 0.6 1.5 0.9 -0.9 -0.8 -0.7 -0.3 0.2 -0.2 -1.2 -0.8 0.8
Illnesses of father: High blood pressure 0.9 1.1 3.6 -1.4 0.1 1.9 0.1 0.9 0.2 0.8 0.1 1.9 -0.6
Alcohol drinker status: Never 0.9 1.1 2.7 0.9 0.3 -1.2 1.6 0.4 0.1 1.1 0.6 -1.2 1.5
Ever smoked 1.1 2.0 6.3 -1.0 -1.2 1.0 -2.5 -0.8 0.7 -2.0 -1.3 1.2 -1.5
Basal metabolic rate 0.6 3.5 6.8 -2.6 0.7 1.9 2.6 0.3 -2.0 1.0 1.9 2.1 -2.2
Leg fat percentage (left) 0.2 0.6 2.0 -1.1 -1.0 0.4 -0.8 0.1 0.1 -0.8 -1.4 0.5 -0.7
Arm fat-free mass (left) 0.7 3.5 9.5 -3.1 0.4 2.2 2.5 0.9 -1.1 0.6 1.6 2.4 -1.8
Number of operations (self-reported) 0.8 1.2 4.7 -0.1 -1.0 0.5 -2.2 0.6 1.3 -1.0 -1.7 0.5 0.1
Average weekly beer plus cider intake 1.1 1.5 3.7 -1.9 -0.5 1.4 1.8 1.6 1.4 -0.1 0.3 1.2 0.1
Irritability 0.6 1.0 3.2 -1.1 0.9 1.8 0.0 0.8 0.4 0.9 0.6 1.8 -0.3
Risk taking 0.1 0.1 0.4 0.3 0.6 -0.2 -0.5 -0.2 0.1 0.6 0.4 -0.1 -0.0
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.0 0.9 -0.6 -0.9 0.2 -0.1 -0.4 0.1 -0.9 -1.0 0.9
Fractured/broken bones in last 5 years 1.1 1.4 3.6 -1.9 -1.4 0.9 -0.6 -0.3 -0.4 -1.7 -0.4 1.0 -1.8
Age started oral contraceptive pill 0.2 0.3 0.8 0.7 0.3 -0.6 -0.3 -0.2 0.9 -0.2 -0.1 -0.6 0.9
Diastolic blood pressure, automated reading 0.3 0.8 2.5 0.4 -0.8 -0.2 -1.5 -0.6 0.2 -1.4 -1.6 -0.2 -0.3
Ever depressed for a whole week 1.8 2.3 4.8 0.4 1.3 0.8 1.6 1.8 2.2 2.0 1.1 0.6 2.0
Unable to work because of sickness or disability 0.7 0.9 3.4 0.7 -0.9 -0.6 -1.4 -1.1 -0.5 -0.6 -1.8 -0.5 -0.4
Commuting to job workplace: Cycle 0.5 0.6 0.9 1.0 0.7 -0.7 0.9 -0.1 -0.8 0.7 0.8 -0.7 0.9
Myopia 0.8 1.2 4.4 -0.9 0.5 0.7 0.4 1.7 2.1 0.7 0.1 0.6 1.4
Vascular/heart problems diagnosed by doctor 1.3 3.6 6.9 -1.0 2.2 1.7 2.4 2.1 0.8 2.6 2.4 1.7 0.8
Cholesterol lowering medication 0.9 1.3 4.0 0.8 -0.9 -0.1 -1.0 0.8 2.0 -0.4 -1.7 -0.2 1.7
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 3.0 1.7 -0.5 -1.7 -0.4 -1.4 -1.3 -0.4 -0.6 -1.7 0.4
Pain experienced in last month 0.9 1.5 5.3 -0.6 -1.8 0.2 -0.9 0.7 2.3 -1.5 -1.3 0.1 1.2
Supplements: Calcium 0.3 0.3 0.9 0.2 0.9 -0.4 0.9 0.3 0.4 0.6 0.5 -0.3 0.5
Basal cell carcinoma (self-reported) 2.2 2.6 6.9 2.5 -0.7 -2.6 -0.5 -1.8 -0.6 -0.6 -0.8 -2.6 1.0
Heart attack/myocardial infarction (self-reported) 2.8 3.7 10.0 0.6 -2.6 -0.5 -3.0 -1.7 -0.1 -2.4 -3.2 -0.4 -1.2
Deep venous thrombosis (DVT) (self-reported) 1.1 1.5 2.7 -1.5 0.8 1.4 0.1 0.3 -0.5 1.5 1.6 1.6 -1.4
Heart disease (siblings) 1.4 1.7 4.5 -0.5 -2.1 0.1 -1.6 -0.7 -0.7 -1.9 -2.0 0.0 -1.3
Alcohol drinker status: Previous 0.9 1.0 4.0 0.3 -0.5 -0.1 -2.0 -1.2 -1.2 -0.7 -0.6 -0.0 -1.3
Pack years of smoking 0.4 0.6 1.3 1.1 -0.2 -1.1 -0.1 -0.5 0.7 -0.8 -0.3 -1.1 0.9
Impedance of whole body 0.3 1.6 5.7 1.3 0.4 -0.1 -1.8 0.9 2.4 0.4 -0.9 -0.3 1.9
Leg fat mass (left) 0.3 1.1 3.8 -1.9 -0.6 1.1 0.3 0.1 -1.1 -0.3 -0.4 1.2 -1.7
Arm predicted mass (left) 0.8 3.9 10.2 -3.2 0.5 2.4 2.5 0.9 -1.3 0.7 1.6 2.6 -2.0