Hub : Genes

SCYL3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0620	0.0250	1.4e-03	0.020	0.027	0.028	0.028	0.040	1.7e-03	2.4e-04	2.0e-04	2.2e-04	1.2e-05
2	GTEx	Brain Cerebellum	0.2020	0.0640	5.7e-04	0.122	NA	0.171	NA	0.182	1.9e-04	NA	9.2e-06	NA	4.7e-06
3	GTEx	Cells Transformed fibroblasts	0.0860	0.0360	5.8e-03	0.041	NA	0.026	NA	0.026	4.8e-04	NA	4.6e-03	NA	4.4e-03
4	GTEx	Colon Sigmoid	0.2310	0.1050	8.1e-03	0.090	NA	0.016	NA	0.027	4.5e-04	NA	8.4e-02	NA	4.0e-02
5	GTEx	Esophagus Gastroesophageal Junction	0.1360	0.0550	3.3e-03	0.027	NA	0.047	NA	0.006	3.7e-02	NA	8.2e-03	NA	1.9e-01
6	GTEx	Muscle Skeletal	0.0545	0.0209	1.4e-03	0.047	NA	0.043	NA	0.049	2.2e-05	NA	4.2e-05	NA	1.5e-05
7	GTEx	Skin Sun Exposed Lower leg	0.0740	0.0330	6.3e-03	0.054	NA	0.027	NA	0.030	2.6e-05	NA	2.5e-03	NA	1.4e-03
8	GTEx	Uterus	0.2860	0.0980	2.6e-03	0.157	NA	0.058	NA	0.125	4.4e-04	NA	2.6e-02	NA	1.7e-03
9	YFS	Blood	0.0316	0.0093	1.2e-07	0.037	0.026	0.029	0.027	0.034	4.0e-12	4.8e-09	4.9e-10	2.3e-09	2.2e-11
10	TCGA	Brain Lower Grade Glioma	0.0499	0.0285	4.1e-04	0.000	0.034	0.019	NA	0.003	2.8e-01	8.8e-05	2.9e-03	NA	1.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.2	0.4	0.9	0.7	-0.5	-0.7	0.5	0.0	0.4	-0.3	-0.6	-0.9	0.9
Bipolar Disorder or Schizophrenia	1.0	2.4	6.7	1.3	1.7	-0.5	2.6	0.9	0.9	1.9	1.4	-0.8	2.1
Depressed Affect (Nagel 2018)	0.3	0.7	1.8	-1.3	-0.4	1.4	-0.3	0.8	0.3	0.2	-0.2	1.3	-0.4
Depression (Nagel 2018)	0.2	0.4	1.3	-0.2	-0.3	0.9	-0.7	0.2	0.4	0.0	-1.1	0.8	-0.3
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.9	-1.1	-1.0	0.5	-0.7	0.2	0.0	-1.4	-0.6	0.4	-0.9
Neuroticism (Nagel 2018)	0.2	0.5	1.7	0.2	-0.5	0.4	-1.3	0.5	0.8	0.5	-1.1	0.4	0.6
Schizophrenia (2018)	1.7	3.5	8.5	1.1	2.6	-0.1	2.9	1.1	0.9	2.7	2.3	-0.3	2.0
Schizophrenia vs Biploar Disorder	1.0	1.4	4.0	0.2	0.8	0.3	1.4	1.5	1.4	1.5	0.6	0.1	2.0
Worry (Nagel 2018)	0.4	0.9	2.7	1.6	-0.2	-0.8	-1.3	-0.4	0.3	0.3	-1.7	-0.9	0.9
Alzheimer’s Disease (in mother)	0.2	0.2	1.1	0.1	-0.3	0.3	0.3	0.2	0.7	-0.3	-1.1	0.2	0.3
Alzheimer’s Disease (in father)	0.6	0.6	2.2	-1.5	-0.2	0.9	0.3	0.8	1.0	-0.2	0.3	1.0	-0.4
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	0.4	-0.6	-0.7	0.6	-0.1	0.9	-0.2	-0.7	-0.7	0.7
Crohns Disease (2017)	1.8	3.9	10.8	-0.5	3.3	1.5	2.1	0.3	-1.4	2.2	3.2	1.9	-1.0
Irritable Bowel Disease (IBD)	2.1	5.0	14.5	-1.3	3.4	1.6	2.4	-0.3	-1.6	1.8	3.8	2.1	-1.9
Ulcerative Colitis (UC)	1.9	3.6	9.9	-1.7	2.7	1.6	1.9	-0.2	-0.8	1.5	3.1	2.0	-1.7
Major Depression (MDD)	2.0	2.4	6.9	-0.9	0.9	1.5	0.7	2.3	2.6	1.8	0.4	1.3	1.5
Reaction Time	0.6	1.2	4.2	2.0	0.0	-1.4	0.4	-0.5	0.3	0.6	-0.7	-1.5	1.5
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.3	-1.5	0.3	1.3	-0.5	0.2	-0.6	-0.2	0.1	1.4	-1.5
Breast Cancer	0.6	1.4	3.4	-1.0	1.7	1.0	1.5	0.8	0.1	1.1	1.9	1.0	-0.3
Ovarian Cancer	0.4	0.5	1.5	-0.1	-0.5	-1.0	0.7	-1.2	-0.6	-0.6	0.5	-0.8	-0.5
Prostate Cancer	0.1	0.2	0.8	-0.1	0.3	0.4	-0.9	-0.3	0.1	-0.3	-0.2	0.4	-0.3
Age at First Birth	0.5	0.7	2.6	-0.5	0.6	0.4	-0.9	-0.9	-1.0	-0.6	0.3	0.6	-1.6
Bipolar Disorder (2011)	0.4	0.4	1.4	0.3	0.2	0.2	0.7	0.8	1.2	0.1	-0.6	0.1	1.1
Body Mass Index (BMI) (2010)	0.3	0.5	1.2	-1.1	0.0	1.1	0.3	0.6	0.5	-0.3	0.1	1.1	-0.6
Coronary Artery Disease (CAD)	0.3	0.3	1.0	0.5	0.5	-0.1	0.8	0.2	0.7	1.0	-0.3	-0.2	0.8
Crohns Disease (2012)	0.7	1.1	1.9	0.6	1.4	0.6	1.4	0.1	-1.4	1.4	1.3	0.9	-0.0
Mean Putamen Volume	1.4	1.6	3.4	1.7	0.5	-1.7	1.2	-1.4	-1.8	0.1	0.6	-1.7	-0.1
Fasting Glucose	1.2	1.5	3.9	-1.6	0.7	1.7	0.9	2.0	0.5	1.1	0.4	1.6	-0.0
HbA1C	0.5	0.6	1.5	-0.5	1.2	1.0	-0.2	-0.0	0.6	0.6	1.0	1.1	-0.3
HDL Cholesterol	0.7	1.1	2.9	1.3	-1.0	-1.6	0.2	-0.7	0.3	-0.7	-0.6	-1.7	1.1
LDL Cholesterol	0.3	0.4	1.8	-0.5	-0.2	0.4	-0.4	1.0	1.3	-0.1	-0.5	0.3	0.7
Lupus	0.3	0.5	1.1	0.8	-0.6	-0.9	0.8	-0.3	-0.2	-0.8	-0.2	-1.0	0.5
Neuroticism (2016)	1.1	1.6	4.2	-1.4	-0.6	2.0	-1.2	0.8	0.6	-0.1	-1.1	2.0	-1.1
Primary Biliary Cirrhosis	0.7	0.9	2.6	0.6	-1.6	-0.7	-0.4	0.5	1.0	-0.6	-1.2	-0.9	1.4
Rheumatoid Arthritis	0.5	0.7	2.2	-0.7	-1.5	0.6	-0.8	-0.0	-0.3	-1.1	-1.1	0.5	-0.6
Schizophrenia (2014)	1.3	2.8	6.1	1.3	1.7	-0.3	2.5	1.3	1.2	2.3	1.5	-0.5	2.5
Triglycerides	1.0	1.7	3.9	-1.1	0.3	2.0	-0.7	1.6	2.0	0.7	-0.1	1.9	0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	0.3	-0.6	-0.5	-0.2	0.1	0.1	-0.4	-0.2	-0.6	0.2
Ulcerative Colitis	1.0	1.5	6.1	-0.5	1.9	0.5	1.6	-0.5	-0.6	0.8	2.5	0.8	-0.7
Blood Eosinophil Count	0.7	5.1	13.7	3.7	0.2	-3.2	1.6	-1.1	0.4	1.3	0.6	-3.2	3.2
Blood Platelet Count	0.4	4.6	14.4	3.8	-0.4	-3.2	-0.0	-1.9	-0.2	0.0	-0.9	-3.3	2.2
Blood Red Count	0.1	1.1	4.5	-2.1	-0.2	1.4	0.4	1.5	0.0	0.2	-0.1	1.2	-0.6
Blood White Count	0.5	3.4	10.2	-0.3	3.2	0.5	1.8	-0.4	-2.1	2.4	2.9	0.7	-1.2
Heel T-Score	0.3	2.3	4.9	-0.5	1.4	1.8	-0.7	2.1	2.2	1.8	-0.1	1.7	1.3
BMI	0.1	0.5	2.3	-0.5	-1.5	-0.1	0.1	0.2	-0.6	-0.3	-1.3	-0.3	0.2
Height	0.3	6.1	21.1	-3.1	1.1	2.0	0.7	-1.4	-3.2	-1.1	2.1	2.6	-4.6
Waist Hip Ratio (WHR)	1.1	4.9	10.0	-1.0	-2.4	2.3	-2.8	-0.0	1.4	-2.8	-3.2	2.2	-2.1
Systolic Blood Pressure	0.4	2.0	6.8	-0.8	-1.5	-0.3	-1.8	-1.3	0.0	-2.6	-1.3	-0.1	-1.7
Smoking Status	1.6	3.9	9.9	-2.3	-0.7	2.1	-2.7	-0.6	-0.5	-2.0	-0.7	2.4	-3.1
Allergy or Eczema	1.3	3.4	6.4	1.8	-2.5	-2.1	0.0	-0.0	1.6	-1.2	-2.0	-2.4	2.5
Cardiovascular Disease	0.7	2.4	5.8	0.7	-2.3	-1.4	-1.9	-1.0	-0.5	-2.0	-2.4	-1.5	-0.2
Hypothyroidism (self reported)	0.6	1.3	4.2	0.5	-0.5	0.6	-2.0	0.6	1.9	-0.1	-1.3	0.5	1.2
Respiratory disease	0.3	0.6	1.6	-0.4	-0.8	0.7	0.0	1.2	1.2	-0.0	-0.8	0.5	0.9
Type 2 Diabetes (T2D) (2018)	1.8	3.3	10.0	0.4	-3.2	-0.6	-2.2	-0.7	0.3	-2.6	-3.1	-0.8	-0.1
Lung FEV1/FVC ratio	0.3	1.6	3.2	1.8	0.5	-1.6	1.6	-0.5	-0.2	1.4	0.2	-1.7	1.6
Lung FVC	0.5	2.3	4.7	2.1	-1.4	-2.2	-0.6	-1.4	-0.7	-1.8	-0.8	-2.2	0.7
Neuroticism	0.1	0.3	0.7	-0.2	0.3	0.8	-0.6	0.7	0.4	0.8	-0.2	0.8	-0.0
Chronotype (morning person)	0.3	0.7	2.4	1.2	1.1	-0.4	0.9	-0.0	-0.8	1.6	0.2	-0.5	0.7
Hair Pigment	0.0	0.8	2.3	0.0	-0.1	-0.4	-1.5	-1.0	-1.5	-0.6	-0.3	-0.2	-1.2
Tanning	0.1	1.4	5.2	-1.4	0.7	1.1	-0.8	-0.6	-1.7	0.1	0.2	1.2	-2.3
Hand grip strength (left)	0.2	0.6	1.7	-1.3	-0.1	0.9	0.2	1.2	0.7	0.1	0.6	0.8	0.4
Number of treatments/medications taken	1.3	2.4	8.0	0.5	-2.1	-0.3	-2.5	-0.4	0.7	-1.9	-2.8	-0.4	0.3
Average weekly spirits intake	3.2	4.0	9.2	1.3	-2.4	-1.7	-2.0	-2.9	-0.7	-3.0	-2.2	-1.5	-1.0
Sensitivity / hurt feelings	0.8	1.4	2.8	-0.9	0.9	1.6	0.3	1.7	1.2	1.6	0.1	1.5	0.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.8	0.7	-0.2	0.1	-0.7	0.1	0.9	0.5	-0.8	0.0	0.8
Hearing difficulty/problems: Yes	0.3	0.5	2.1	-0.5	-0.2	0.8	-1.4	0.2	0.5	-0.4	-0.7	0.8	-0.6
Relative age of first facial hair	1.2	2.5	6.9	0.7	2.6	-0.2	1.9	0.1	0.2	2.6	2.6	-0.0	0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.9	0.6	0.1	-0.3	-1.7	0.2	0.8	0.4	-1.1	-0.2	1.1
Ever used hormone-replacement therapy (HRT)	1.6	2.0	4.6	1.6	-0.9	-1.0	-1.7	0.2	1.5	-0.8	-2.1	-1.3	1.9
Ever had hysterectomy (womb removed)	2.3	2.6	5.1	-1.8	-0.9	1.8	-1.5	1.7	2.2	-1.2	-2.2	1.6	-0.1
Systolic blood pressure, automated reading	0.4	1.2	2.7	0.3	-0.7	-0.8	-1.3	-1.5	-0.8	-1.6	-1.0	-0.7	-1.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.1	-0.3	-0.4	0.3	-0.1	0.4	-0.1	0.4	-0.4	0.5
Angina	1.4	1.8	5.9	2.0	-1.1	-1.5	-0.2	0.1	0.9	0.2	-1.1	-1.7	2.4
Medication for hormone replacement therapy	2.5	2.8	7.8	1.3	-2.0	-1.1	-2.8	-1.0	0.7	-1.7	-2.7	-1.2	0.6
Vitamin and mineral supplements	0.5	0.7	1.4	0.2	-0.6	-0.4	-1.0	-1.2	-1.0	-1.2	-0.5	-0.3	-1.0
Supplements: Zinc	2.3	2.4	9.4	0.3	3.1	0.3	1.6	0.5	-0.6	2.6	2.2	0.5	-0.1
Medication: Co-codamol	1.1	1.3	4.4	0.6	-1.7	-0.9	-0.5	-0.3	0.1	-1.5	-2.1	-1.1	0.7
Medication: Metformin	0.2	0.2	0.7	-0.7	-0.6	0.3	-0.0	0.6	0.9	-0.1	-0.5	0.3	0.3
Diabetes (father)	0.7	0.8	2.2	0.5	-1.5	-0.9	-1.3	-0.3	-0.1	-1.0	-1.2	-1.0	0.4
Diabetes (mother)	0.1	0.2	0.7	-0.4	-0.1	0.1	-0.3	0.0	-0.9	-0.3	-0.6	0.2	-0.7
Severe depression (siblings)	0.4	0.4	2.5	0.0	0.1	0.4	0.5	0.6	1.6	0.3	-0.0	0.4	1.0
Pack years adult smoking proportion	0.1	0.2	0.6	0.6	0.3	-0.5	0.1	-0.2	0.8	-0.4	0.2	-0.5	0.7
Impedance of leg (right)	0.5	2.6	12.0	0.7	-0.5	0.3	-2.6	0.7	3.5	-0.8	-1.7	0.1	1.5
Leg fat-free mass (left)	0.7	3.5	6.9	-2.2	0.8	1.4	2.6	-0.2	-2.6	1.1	2.0	1.7	-2.4
Trunk fat percentage	0.1	0.2	1.3	-0.5	-0.6	0.2	-0.5	0.1	-0.4	0.1	-1.2	0.1	-0.2
Hand grip strength (right)	0.3	0.7	1.4	-0.8	-1.2	0.6	-0.6	1.0	1.1	-0.6	-0.8	0.5	0.8
Townsend deprivation index at recruitment	1.0	1.4	4.7	-2.2	-1.0	1.4	-1.1	0.9	0.8	-1.0	-0.6	1.4	-0.8
Current tobacco smoking	0.2	0.3	1.1	-0.4	1.0	-0.0	0.2	-0.5	0.0	0.1	1.0	0.1	-0.6
Average weekly fortified wine intake	0.1	0.2	0.7	-0.0	0.1	-0.3	0.9	-0.4	0.1	-0.3	0.6	-0.3	-0.2
Maternal smoking around birth	1.5	2.2	4.0	-1.3	-1.2	1.5	-1.9	-0.0	1.4	-2.0	-1.7	1.6	-1.3
Fed-up feelings	0.4	0.8	2.3	-1.3	0.2	1.5	-0.4	0.5	-0.0	0.7	-0.4	1.5	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	0.3	-0.0	0.2	-0.6	-0.5	-0.4	0.0	-0.5	0.2	-0.3
Relative age voice broke	1.3	2.0	5.7	0.6	1.2	-0.1	1.4	1.4	1.5	2.2	1.2	-0.2	2.4
Taking other prescription medications	1.4	2.1	6.2	-0.3	-2.1	0.0	-2.5	-0.4	0.7	-2.2	-2.1	-0.0	-0.4
Age when periods started (menarche)	0.9	2.2	5.7	2.2	0.3	-2.4	0.5	-1.3	-1.4	-0.0	1.1	-2.3	0.9
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	6.3	-2.0	0.3	2.5	-1.1	2.2	1.9	-0.4	-0.8	2.4	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	5.3	-1.1	0.0	1.6	-0.0	2.3	2.0	1.1	-1.0	1.3	1.0
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	2.7	-1.2	-0.4	1.2	-0.5	1.3	1.6	0.2	-1.0	1.1	0.5
Qualifications: CSEs or equivalent	1.7	2.2	4.4	-2.1	1.1	2.1	1.1	1.5	0.7	1.7	1.2	2.0	-0.4
Serious illness, injury or assault to yourself	0.9	1.1	4.3	1.1	0.3	-1.1	-1.3	-2.1	-0.5	-0.9	0.7	-0.8	-0.9
High blood pressure	0.9	2.4	4.6	0.7	-1.6	-1.6	-1.9	-1.9	-0.8	-2.1	-1.7	-1.6	-0.8
Hayfever, allergic rhinitis or eczema	0.9	1.9	5.1	1.6	-1.2	-2.1	1.3	-0.6	0.5	-0.7	-0.3	-2.2	1.5
Multivitamins +/- minerals	0.1	0.1	0.3	-0.2	0.0	0.0	0.3	0.5	0.6	0.3	0.0	-0.0	0.5
Stomach or abdominal pain in last month	0.6	0.7	1.7	0.8	0.7	-1.3	0.5	-1.2	-0.8	-0.2	0.7	-1.2	-0.4
Supplements: Glucosamine	0.1	0.1	0.6	-0.2	-0.0	-0.3	0.8	-0.0	-0.7	-0.0	0.4	-0.3	-0.1
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.4	-0.6	1.5	1.1	0.1	1.0	0.8	1.5	0.4	1.2	0.1
Medication: Atenolol	1.8	2.3	4.2	0.7	-1.6	-1.3	-1.7	-2.1	-1.0	-2.0	-1.7	-1.2	-1.3
Medication: Levothyroxine sodium	0.9	1.4	4.6	1.5	-0.8	-0.5	-2.1	-0.9	0.9	-1.3	-1.7	-0.5	0.5
Sitting height	0.2	1.4	4.2	-2.1	-0.3	1.5	1.8	0.9	0.0	0.0	1.0	1.4	-0.6
Chronic bronchitis/emphysema (father)	0.7	0.8	2.7	-0.1	-0.5	0.4	-0.5	1.3	1.6	0.0	-1.6	0.2	0.9
High blood pressure (mother)	1.2	1.6	3.3	1.8	0.0	-1.8	0.4	-1.7	-1.8	-0.0	0.4	-1.7	-0.2
Body mass index (BMI)	0.2	0.8	2.3	-1.4	-0.6	0.5	0.5	-0.2	-1.5	-0.0	-0.5	0.7	-1.5
Impedance of leg (left)	0.5	2.4	12.5	0.6	0.1	0.5	-1.9	1.4	3.5	-0.2	-1.1	0.3	2.1
Leg predicted mass (left)	0.7	3.5	7.3	-2.1	0.9	1.4	2.7	-0.2	-2.6	1.3	2.0	1.6	-2.2
Trunk fat mass	0.1	0.5	1.1	-1.0	-0.6	0.5	-0.1	-0.0	-1.0	-0.0	-0.8	0.6	-0.9
Waist circumference	0.5	1.7	4.4	-2.0	-0.9	1.7	-0.2	0.1	-0.7	-0.7	-1.1	1.7	-2.1
Number of incorrect matches in round	1.2	2.0	4.6	-0.3	-1.0	0.0	-2.0	-1.8	-0.5	-2.0	-1.5	0.3	-2.2
Past tobacco smoking	2.6	4.7	10.7	2.4	1.8	-2.3	3.3	0.3	-0.2	2.3	1.8	-2.5	2.7
Alcohol usually taken with meals	0.4	0.6	1.7	0.8	-0.6	-0.8	-1.3	-0.9	-0.8	-0.6	-0.8	-0.8	-0.2
Nervous feelings	0.3	0.5	2.3	0.9	0.7	-0.4	-1.5	-0.2	0.4	0.9	-0.6	-0.3	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.4	-0.0	0.3	0.6	-0.1	0.5	1.2	0.4	-0.6	0.5	0.8
Hearing difficulty/problems with background noise	0.4	0.7	2.2	-1.0	-0.3	0.5	-0.9	-0.5	-0.8	-1.0	-0.2	0.6	-1.5
Hair/balding pattern: Pattern 2	1.9	2.4	6.1	-1.3	1.6	0.5	1.7	-0.1	-2.0	1.8	2.5	0.8	-1.3
Had menopause	0.4	0.6	1.1	0.1	-0.9	-0.3	-0.9	0.6	1.0	-0.6	-1.0	-0.6	0.9
Had other major operations	0.4	0.5	1.8	1.1	0.2	-0.6	1.4	-0.2	0.3	0.2	0.9	-0.6	0.7
Forced vital capacity (FVC)	0.2	0.9	4.6	-0.5	0.5	0.5	2.1	0.6	-0.2	0.6	1.6	0.5	0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	8.0	-1.0	0.5	1.5	0.6	2.8	2.3	1.4	-0.5	1.2	1.7
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	2.8	-0.1	1.4	1.2	0.4	1.5	1.6	1.7	0.6	1.1	1.1
Qualifications: None of the above	1.8	3.9	11.4	-1.5	-3.4	0.2	-2.4	-0.5	-0.2	-3.3	-2.6	0.1	-1.2
Financial difficulties in last 2 years	0.3	0.4	0.7	-0.8	0.4	0.7	0.6	0.8	-0.5	0.5	0.4	0.6	-0.3
Mouth/teeth dental problems	1.6	2.4	4.4	1.2	-1.8	-2.1	-0.7	-2.0	-1.0	-1.9	-1.4	-2.0	-0.1
Heart attack	3.2	4.1	10.4	0.8	-2.7	-0.8	-3.1	-2.1	-0.5	-2.5	-3.2	-0.7	-1.2
Allergy	0.5	1.2	2.2	-1.2	1.3	1.4	-0.5	0.1	-1.1	0.5	0.7	1.5	-1.4
Pain all over the body in last month	0.6	0.6	1.7	0.9	-0.2	-1.0	-1.1	-1.3	-0.7	-0.5	-0.7	-0.8	-0.4
Diabetes (self-reported)	0.7	1.0	4.3	-0.8	-2.1	-0.1	-0.8	0.1	0.7	-1.5	-1.4	-0.2	-0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	1.0	0.2	-1.0	0.0	-0.4	0.5	0.5	-0.4	-0.6	-0.0	0.3
Medication: Ramipril	2.1	2.6	5.5	0.4	-2.0	-1.1	-1.6	-1.6	-2.3	-2.0	-1.6	-1.1	-1.5
Medication: Simvastatin	0.8	1.2	3.1	0.3	-1.6	-0.7	-1.8	-0.5	-0.2	-1.5	-1.5	-0.7	-0.3
Fluid intelligence score	0.4	0.9	2.6	-1.5	0.4	1.6	-0.6	0.6	0.1	-0.1	0.0	1.6	-0.8
Illnesses of siblings	1.7	2.4	4.2	-0.5	2.1	0.9	1.9	1.6	1.7	2.0	1.9	0.8	1.1
Neuroticism score	1.0	2.1	4.9	-1.4	1.1	2.2	-0.2	1.8	1.3	1.7	0.1	2.2	0.2
Weight	0.4	1.8	4.4	-2.1	0.1	1.4	1.3	0.1	-1.8	0.5	0.6	1.5	-1.9
Impedance of arm (right)	0.3	1.2	5.0	2.2	0.8	-0.9	-1.1	-0.3	0.8	0.9	-0.2	-1.1	1.3
Arm fat percentage (right)	0.1	0.4	1.4	-0.3	-0.8	0.0	-0.2	-0.4	-1.1	-0.0	-1.2	-0.0	-0.8
Trunk fat-free mass	0.6	3.3	6.4	-2.5	0.7	1.8	2.5	0.2	-2.0	0.6	2.0	2.0	-2.2
Hip circumference	0.3	1.4	4.1	-1.4	0.7	0.5	1.7	-0.0	-2.0	1.1	1.2	0.6	-1.2
Time employed in main current job	2.8	3.2	6.3	1.6	-2.5	-2.4	-0.2	-1.4	-0.5	-2.3	-1.7	-2.5	0.8
Alcohol intake versus 10 years previously	1.2	1.7	4.9	-1.8	0.2	1.7	-0.8	0.1	-1.2	-0.7	0.2	1.9	-2.2
Father’s age at death	1.6	2.2	7.9	2.8	-0.4	-2.1	0.1	-1.4	0.0	0.1	-0.9	-2.1	1.4
Worrier / anxious feelings	0.6	1.1	4.8	0.2	1.0	0.8	0.1	1.5	1.0	2.2	0.1	0.7	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.4	0.6	0.8	-0.2	1.2	-0.4	-0.7	0.9	0.6	-0.2	-0.2
Falls in the last year	1.1	1.5	3.2	-1.6	-0.8	1.8	-1.2	0.9	1.3	-0.5	-1.2	1.8	-0.5
Hair/balding pattern: Pattern 3	1.3	1.9	4.7	2.0	0.2	-2.0	1.7	-0.3	0.3	0.1	0.4	-2.2	1.7
Number of live births	0.4	0.5	1.2	0.3	0.2	-0.4	0.8	0.7	1.1	0.6	0.9	-0.4	1.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	10.1	0.1	1.4	0.1	3.2	0.8	-0.5	2.0	2.1	0.1	1.0
Pulse rate	0.8	1.3	2.2	1.2	-1.4	-1.4	-1.2	-0.5	0.6	-0.9	-1.3	-1.5	1.2
Happiness	2.5	3.1	6.5	2.3	0.9	-2.1	2.2	-0.3	0.7	1.2	1.2	-2.4	2.5
Noisy workplace	1.9	2.3	9.6	1.0	0.8	-1.0	-0.1	-2.1	-3.1	-0.0	1.4	-0.6	-2.0
Qualifications: A levels/AS levels or equivalent	0.3	0.7	3.0	1.0	-0.0	-0.5	0.8	0.6	0.8	0.6	-0.3	-0.7	1.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.7	0.8	0.2	-0.6	-0.3	-0.4	0.5	0.0	-0.3	-0.4	0.5
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	0.8	-0.1	-0.3	-0.5	0.5	-0.0	0.1	-0.4	-0.5	0.7
Asthma	0.7	1.3	4.0	-0.3	0.1	0.8	1.0	2.0	1.6	1.2	-0.4	0.6	1.6
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	5.4	-1.3	2.3	2.0	0.9	1.0	-0.1	1.6	2.3	2.2	-1.1
Medication: Cholesterol lowering	1.3	1.9	4.3	0.1	-2.1	-1.0	-1.7	-1.1	-1.4	-1.8	-1.8	-0.9	-1.0
Depression (self-reported)	0.8	0.9	1.7	-1.0	1.1	1.2	0.9	0.8	-0.4	1.3	0.8	1.2	-0.4
Medication: Lansoprazole	0.8	0.9	2.3	0.8	-1.4	-0.9	-0.4	-0.6	-0.2	-1.3	-1.5	-0.9	0.2
Prospective memory result	0.8	1.0	3.2	-0.4	-0.2	-0.6	-0.2	-1.4	-1.6	-1.4	-0.2	-0.3	-1.8
Lung cancer (father)	0.7	0.8	2.7	-1.6	-0.4	1.3	-0.5	1.0	0.5	-0.5	-0.5	1.2	-0.7
Illnesses of mother	0.5	0.6	1.3	-1.0	0.5	1.0	-0.0	1.1	0.8	1.0	0.6	0.9	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	10.6	-0.6	2.2	0.9	3.3	0.8	-0.8	2.4	3.0	1.0	0.1
Pulse wave Arterial Stiffness index	1.6	1.9	4.7	0.4	-0.3	-1.4	-1.5	-2.2	-1.9	-1.4	-0.6	-1.2	-1.6
Impedance of arm (left)	0.2	1.0	3.5	1.9	0.8	-0.7	-1.4	-0.1	0.6	0.9	-0.3	-0.9	1.1
Arm fat mass (right)	0.2	0.7	2.0	-1.1	-0.2	0.6	0.6	-0.2	-1.4	0.3	-0.2	0.7	-1.3
Trunk predicted mass	0.6	3.4	6.6	-2.5	0.8	1.9	2.6	0.3	-1.9	0.8	2.0	2.1	-2.1
Standing height	0.2	2.4	6.0	-1.5	1.5	1.6	2.0	0.4	-1.1	1.1	2.5	1.7	-1.1
Length of working week for main job	0.2	0.2	0.9	-0.1	0.4	0.3	0.7	0.4	-0.9	0.7	0.2	0.2	-0.1
Exposure to tobacco smoke at home	0.5	0.5	1.8	-0.7	-0.8	0.4	-0.3	-0.3	0.6	-1.4	-1.0	0.4	-0.7
Breastfed as a baby	0.3	0.4	1.2	-0.5	0.3	-0.3	-1.1	-0.6	0.3	-1.0	0.4	-0.2	-0.7
Tense / ‘highly strung’	2.0	3.3	13.9	1.6	0.1	-0.4	0.3	1.9	3.0	1.4	-0.8	-0.8	3.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	6.8	-0.0	0.8	0.9	0.6	2.4	2.6	1.9	-0.0	0.6	2.5
Hair/balding pattern: Pattern 4	4.6	11.2	27.6	-1.9	-4.1	2.5	-3.9	1.7	4.6	-3.8	-5.2	2.1	0.2
Birth weight of first child	0.5	0.8	2.0	-1.1	0.2	1.4	0.9	0.8	0.9	0.2	1.0	1.4	0.1
Peak expiratory flow (PEF)	1.6	3.6	7.6	-1.6	2.0	1.5	2.4	1.9	0.1	2.8	2.6	1.6	0.4
Pulse wave reflection index	0.7	0.8	2.8	0.3	-0.0	-1.0	-0.5	-1.3	-1.7	-0.7	-0.0	-0.9	-1.0
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.3	1.5	0.8	-1.4	0.3	-1.1	-0.9	0.3	0.9	-1.3	0.4
Loud music exposure frequency	0.4	0.5	1.3	0.3	0.4	0.5	-0.3	1.0	0.8	1.2	-0.4	0.4	0.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.0	-0.0	1.4	0.3	1.4	0.2	-0.1	1.1	1.4	0.4	-0.2
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	4.2	-0.6	1.6	1.4	1.2	2.0	1.5	1.5	1.1	1.2	1.1
Blood clot in the leg (DVT)	1.5	1.9	4.0	-1.5	1.2	1.6	0.2	0.8	-0.1	2.0	1.9	1.8	-1.0
Medication: Paracetamol	0.1	0.2	0.8	-0.4	-0.2	0.2	0.9	-0.2	-0.7	-0.2	0.1	0.3	-0.5
Headache pain in last month	0.2	0.3	0.9	0.7	-0.4	-0.8	0.1	-0.3	-0.6	-0.3	-0.3	-0.9	0.3
Medication for cholesterol, blood pressure or diabetes	3.9	6.5	11.9	-1.4	3.5	2.6	2.7	2.5	1.7	3.4	3.0	2.6	0.8
Glaucoma (self-reported)	0.6	0.7	2.5	0.5	-1.6	-0.9	-0.3	-0.1	0.3	-1.2	-0.7	-1.1	0.6
Gout (self-reported)	1.5	2.1	5.7	-0.1	-1.6	-0.8	-2.3	-1.4	-0.8	-2.4	-1.3	-0.7	-1.4
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.5	1.0	-0.6	0.2	-1.9	-0.1	1.3	-0.5	-1.4	0.1	1.0
Medication: Amlodipine	0.2	0.3	0.7	-0.1	-0.8	-0.5	-0.5	-0.7	-0.1	-0.8	-0.4	-0.5	-0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.3	-0.6	0.1	0.9	0.8	1.1	0.1	0.5	0.1	0.8	0.4
Birth weight	0.5	1.2	4.1	-0.3	-0.7	-0.9	-0.0	-1.6	-2.0	-1.1	0.2	-0.7	-1.3
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.3	-0.8	0.3	1.1	-0.3	0.9	0.5	0.3	-0.0	1.1	-0.1
High blood pressure (siblings)	1.5	2.2	4.5	0.5	-2.1	-0.6	-1.5	-1.2	-1.7	-2.1	-2.0	-0.7	-0.9
Forced vital capacity (FVC), Best measure	0.7	2.5	7.6	-1.0	1.6	1.3	2.8	1.0	-0.4	1.6	2.6	1.4	0.0
Body fat percentage	0.1	0.4	1.8	-0.8	-0.9	0.4	-0.6	0.1	-0.4	-0.3	-1.3	0.3	-0.6
Leg fat percentage (right)	0.3	1.1	2.9	-1.0	-1.3	0.3	-1.4	-0.5	0.0	-1.2	-1.7	0.4	-1.1
Arm fat-free mass (right)	0.7	3.5	10.2	-3.2	0.3	2.3	2.2	1.1	-1.0	0.6	1.5	2.5	-1.7
Exposure to tobacco smoke outside home	0.1	0.2	0.6	-0.3	-0.1	0.4	-0.2	-0.8	0.5	0.0	0.0	0.5	-0.6
Comparative body size at age 10	0.4	1.1	2.2	-1.5	0.6	1.3	1.2	0.3	-1.3	0.6	0.5	1.4	-1.3
Number of full brothers	0.3	0.4	1.6	0.8	0.4	-0.3	-0.6	-0.5	-1.2	0.5	-0.1	-0.3	-0.4
Worry too long after embarrassment	0.6	1.0	2.5	-0.5	0.9	1.2	0.2	1.3	0.9	1.6	0.7	1.2	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	4.0	0.8	0.8	-0.8	0.9	0.9	0.6	1.5	0.3	-0.9	2.0
Wheeze or whistling in the chest in last year	0.5	0.8	2.8	-0.6	-1.7	-0.1	-0.9	-0.3	0.6	-1.5	-1.2	0.0	-0.4
Number of children fathered	0.6	0.6	1.4	-1.1	-0.9	0.7	-0.5	0.6	0.6	-1.2	-0.8	0.6	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.8	-0.2	-0.8	-0.1	-1.1	-0.8	-0.4	-1.3	-0.9	-0.1	-1.0
Age at first live birth	0.5	0.9	3.4	0.5	0.8	0.3	0.9	1.1	1.1	1.9	0.5	0.0	1.2
Pulse wave peak to peak time	1.9	2.2	5.6	-0.7	0.4	1.7	1.6	2.4	1.9	1.5	0.7	1.5	1.4
Health satisfaction	0.4	0.6	1.8	1.3	0.3	-1.0	0.6	-0.5	-0.1	0.6	0.4	-1.0	0.7
Shortness of breath walking on level ground	1.3	1.5	4.7	1.1	-0.8	-1.5	-1.2	-2.2	-1.0	-1.0	-1.0	-1.3	-0.7
Qualifications: College or University degree	0.7	2.2	8.5	0.3	0.6	0.1	1.6	2.2	1.9	1.5	0.6	-0.1	2.9
Eye problems/disorders: None of the above	1.3	1.5	3.2	-1.8	0.9	1.7	0.5	1.0	-0.4	1.1	1.0	1.7	-1.0
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.5	-0.8	0.1	1.4	-1.1	1.5	1.9	0.1	-0.4	1.4	0.7
Emphysema/chronic bronchitis	0.9	1.0	2.2	-0.0	-1.5	-0.4	-0.7	0.3	1.3	-1.4	-1.4	-0.5	0.9
Medication for pain relief, constipation, heartburn	0.2	0.4	1.1	0.9	0.0	-1.0	0.4	-0.5	0.2	0.1	0.1	-1.0	0.7
Neck or shoulder pain in last month	0.9	1.2	3.3	-0.3	1.6	1.0	0.8	1.3	0.5	1.8	0.9	1.0	0.9
Medication: Blood pressure	4.2	7.5	11.8	1.7	-3.1	-3.0	-2.7	-3.4	-2.6	-3.2	-2.5	-2.9	-1.4
Angina (self-reported)	1.8	2.4	7.1	2.3	-1.2	-1.8	-0.3	-0.0	1.0	0.0	-1.4	-1.9	2.7
Migraine (self-reported)	0.3	0.3	1.7	-0.4	-1.3	-0.0	-0.1	-0.2	-0.5	-0.9	-0.2	-0.0	-0.6
Medication: Ibuprofen	1.7	2.1	4.4	-1.2	1.9	1.9	0.9	0.9	0.2	1.3	2.1	2.0	-1.0
Medication: Allopurinol	2.5	3.3	10.2	0.0	-2.8	-0.6	-2.4	-1.6	-0.2	-3.2	-2.3	-0.6	-1.2
Medication: Omeprazole	0.4	0.5	1.4	1.2	-0.4	-1.0	-0.4	-0.7	-0.2	-0.2	-0.7	-1.0	0.7
Medication: Seretide 50 evohaler	1.7	2.0	6.9	0.8	-2.0	-0.8	-1.9	-0.5	0.3	-1.7	-2.6	-0.9	0.4
Mean time to correctly identify matches	1.1	2.0	4.6	2.1	-0.8	-2.1	-0.8	-1.5	-0.5	-0.8	-1.4	-2.1	0.7
Heart disease (mother)	0.1	0.2	0.5	-0.2	0.4	0.5	0.4	0.4	0.7	-0.1	0.4	0.5	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.0	-1.0	1.3	1.0	0.8	1.0	-0.1	1.1	1.4	1.0	-0.2
Whole body fat mass	0.2	0.7	1.9	-1.4	-0.5	0.8	0.2	-0.0	-1.2	0.0	-0.5	0.8	-1.3
Leg fat mass (right)	0.3	1.2	3.7	-1.9	-0.6	1.0	0.0	-0.2	-1.1	-0.4	-0.5	1.2	-1.9
Arm predicted mass (right)	0.8	4.2	10.4	-3.2	0.8	2.2	2.6	0.8	-1.6	0.9	2.0	2.5	-2.1
Pulse rate, automated reading	1.0	3.4	7.8	2.0	-2.3	-2.1	-1.1	-1.3	0.2	-2.1	-2.8	-2.2	0.9
Alcohol intake frequency.	0.1	0.3	1.9	-0.2	-0.1	-0.4	-0.5	-0.4	-1.4	-0.0	-0.0	-0.3	-0.7
Comparative height size at age 10	0.4	2.3	6.9	-2.6	0.0	2.3	0.4	0.6	-0.5	-0.1	1.0	2.3	-2.0
Number of full sisters	0.6	0.8	2.7	-1.0	0.5	0.7	-0.6	-0.3	-1.4	-0.1	0.3	0.9	-1.6
Suffer from ‘nerves’	1.9	3.0	5.3	2.3	-1.3	-2.2	-1.5	-2.1	-1.0	-0.9	-2.2	-2.2	0.0
Overall health rating	0.2	0.5	1.7	0.2	-0.9	0.1	-1.0	-0.4	0.8	-0.4	-1.3	0.0	-0.1
Chest pain or discomfort	0.3	0.4	1.0	0.9	-0.0	-1.0	0.8	-0.6	0.3	-0.1	-0.2	-1.0	0.7
Had major operations	0.8	0.9	2.4	-0.7	-0.6	0.9	-1.2	0.8	1.6	-0.6	-1.5	0.8	-0.0
Age at last live birth	0.2	0.3	1.1	0.3	0.6	0.5	0.5	0.8	0.4	1.1	0.3	0.3	0.4
Family relationship satisfaction	4.0	4.9	11.6	-0.4	2.9	0.9	3.4	1.6	0.9	3.4	3.3	0.9	1.3
Leg pain on walking	0.4	0.5	1.6	-0.3	0.2	0.3	-0.9	-1.3	-0.8	-0.4	0.1	0.6	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.9	0.0	0.8	0.0	-0.1	-0.8	-0.7	0.7	1.0	0.2	-1.0
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.3	0.8	-1.0	-1.0	-1.4	-1.7	-1.8	-1.3	-0.7	-0.9	-1.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.1	-1.3	0.6	1.1	1.8	1.6	0.4	0.9	1.1	0.9	0.2
Medication: Aspirin	0.7	1.0	3.9	-0.4	-1.1	0.8	-2.0	0.5	0.8	-0.7	-1.4	0.7	-0.2
Supplements: Vitamin C	1.0	1.2	2.5	-0.4	1.5	0.7	1.3	1.3	0.7	1.6	1.4	0.7	0.7
Knee pain experienced in last month	0.4	0.6	1.7	0.5	-0.5	-0.8	-0.7	-1.3	-0.6	-0.7	-0.6	-0.7	-0.7
Hypertension (Self-reported)	1.0	2.8	5.2	0.7	-1.6	-1.6	-2.0	-2.2	-1.2	-2.3	-1.6	-1.5	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	11.8	1.1	-0.8	-0.6	2.1	1.8	1.6	1.0	-1.1	-1.1	3.4
Illnesses of father: Heart disease	0.7	0.9	2.3	1.5	-0.8	-1.1	-0.1	-0.3	0.0	-0.7	-1.3	-1.2	1.0
Illnesses of siblings: Diabetes	0.7	0.8	1.8	0.7	-1.0	-0.7	-1.1	-1.2	-0.6	-1.4	-1.0	-0.6	-0.5
Smoking status: Previous	3.2	4.7	8.9	-2.5	-1.7	2.6	-3.0	0.1	-0.2	-2.0	-1.7	2.7	-2.8
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.1	9.8	-0.7	2.7	1.3	2.8	1.1	-1.0	3.1	3.1	1.4	-0.1
Whole body fat-free mass	0.6	3.7	7.9	-2.5	0.8	1.8	2.8	0.3	-2.1	1.0	2.1	2.0	-2.1
Leg fat-free mass (right)	0.8	4.5	11.0	-2.3	1.3	1.7	3.3	0.4	-2.6	1.7	2.5	1.9	-2.0
Arm fat percentage (left)	0.1	0.5	1.9	-0.6	-0.6	0.3	-0.3	-0.2	-1.4	0.2	-1.0	0.3	-1.0
Average weekly red wine intake	0.8	1.2	3.7	1.4	1.4	-0.7	0.1	-0.5	-1.1	1.9	1.2	-0.6	0.5
Handedness (chirality/laterality): Left-handed	1.3	1.5	3.3	0.6	1.6	0.6	1.6	1.1	1.3	1.8	0.8	0.5	1.6
Mood swings	1.0	1.8	3.3	-1.8	0.9	1.8	0.9	1.5	0.5	1.6	1.3	1.8	-0.1
Loneliness, isolation	1.0	1.4	2.4	-1.4	-0.8	1.5	-1.6	1.2	1.3	-0.1	-1.2	1.5	-0.0
Long-standing illness, disability or infirmity	0.9	1.3	4.9	-0.6	-0.9	0.9	-2.2	0.1	0.8	-1.0	-1.9	1.0	-0.3
Ever had bowel cancer screening	1.8	2.1	5.0	2.2	1.3	-1.7	1.4	-1.3	-1.5	0.9	1.6	-1.6	0.3
Diabetes diagnosed by doctor	0.7	1.1	3.8	-0.3	-2.0	-0.4	-1.2	-0.8	-0.2	-1.6	-1.3	-0.3	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.7	0.6	0.1	-0.6	-1.1	-1.6	-1.5	-0.6	0.2	-0.3	-1.3
Friendships satisfaction	0.9	1.1	3.7	1.0	1.0	-0.5	1.2	0.8	-0.0	1.9	0.6	-0.7	1.4
Qualifications: nursing, teaching	0.8	1.3	2.6	1.1	-1.6	-0.8	-0.2	0.3	1.4	-0.6	-1.6	-1.0	1.6
Commuting to job workplace: Walk	1.0	1.1	3.8	0.8	0.3	-0.4	1.7	0.7	0.9	1.3	-0.1	-0.5	2.0
Eye problems/disorders: Cataract	0.6	0.7	1.8	1.4	-0.1	-1.0	-0.1	-0.6	0.7	-0.4	-0.8	-1.1	0.9
Mouth/teeth dental problems: Mouth ulcers	2.9	4.6	11.0	-1.6	2.8	2.0	2.6	1.1	-0.4	2.5	3.3	2.2	-1.1
Medication for cholesterol	0.5	0.7	2.0	-0.9	0.5	0.9	1.4	0.9	-0.2	0.8	1.2	0.8	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.3	1.1	-0.4	-0.9	0.2	-0.8	-0.8	0.2	0.1	-0.9	0.3
Back pain experienced in last month	1.4	2.0	4.3	-1.1	2.1	1.8	0.5	1.1	0.1	1.9	1.4	1.8	-0.7
Mineral and other dietary supplements	0.1	0.1	0.3	0.1	0.3	0.3	0.0	0.2	-0.5	0.6	0.1	0.3	-0.0
Breast cancer (self-reported)	1.5	1.8	3.0	1.6	-1.6	-1.4	-1.7	-1.0	0.4	-1.4	-1.3	-1.5	0.7
Asthma (self-reported)	0.6	1.3	3.9	-0.5	0.2	1.0	1.0	2.0	1.6	1.2	-0.1	0.8	1.4
Osteoporosis (self-reported)	0.9	1.2	2.4	1.2	0.8	-1.0	1.4	0.3	-0.0	1.6	0.6	-1.1	1.6
Osteoarthritis (self-reported)	0.7	0.9	1.5	0.2	-0.8	-0.5	-1.1	-1.2	-1.0	-1.2	-1.2	-0.4	-1.1
Medication: Aspirin	1.3	1.7	5.8	-0.8	-1.5	1.1	-2.4	0.6	0.7	-1.1	-2.1	1.0	-0.5
Medication: Gliclazide	0.6	0.6	2.2	-0.6	-0.4	0.1	-0.9	-1.0	-0.7	-1.1	-0.1	0.3	-1.5
Illnesses of father: None of the above (group 1)	1.0	1.3	4.6	0.9	-0.1	-1.4	1.3	0.3	0.9	0.5	0.5	-1.5	2.1
Smoking status: Current	0.2	0.2	0.9	-0.1	0.9	-0.2	0.0	-0.7	0.0	0.1	0.8	-0.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	4.0	0.4	1.4	0.1	2.0	0.7	0.1	1.6	1.3	0.1	0.9
Whole body water mass	0.6	3.6	7.6	-2.5	0.8	1.8	2.8	0.3	-2.1	1.0	2.0	2.1	-2.1
Leg predicted mass (right)	0.8	4.5	11.3	-2.2	1.4	1.6	3.4	0.3	-2.7	1.8	2.6	1.8	-2.0
Arm fat mass (left)	0.2	0.9	2.4	-1.4	-0.3	0.8	0.5	0.0	-1.5	0.3	-0.3	0.9	-1.5
Number of self-reported non-cancer illnesses	0.4	0.7	2.8	-0.0	-0.9	0.0	-1.7	-0.5	0.6	-1.0	-1.2	0.1	-0.2
Average weekly champagne plus white wine intake	1.2	1.7	3.6	1.9	-1.2	-1.8	-0.0	-1.2	0.3	-1.4	-0.6	-1.9	0.8
Miserableness	1.2	2.0	6.7	-2.6	0.2	2.1	0.5	1.1	-0.4	0.2	0.8	2.2	-1.4
Guilty feelings	2.5	3.8	8.6	-1.4	2.0	1.9	1.3	2.3	2.2	2.9	1.7	1.9	1.2
Wears glasses or contact lenses	0.9	1.1	2.2	1.5	-0.7	-1.2	-1.3	-1.0	-0.2	-0.8	-1.3	-1.2	0.4
Ever taken oral contraceptive pill	0.2	0.3	0.7	0.8	0.4	-0.7	0.0	-0.8	0.0	0.0	-0.2	-0.7	0.3
Hearing aid user	3.0	3.4	8.3	0.5	-2.9	-1.2	-2.4	-1.5	-0.1	-2.8	-2.5	-1.2	-0.7
Mother’s age at death	0.3	0.4	0.9	0.9	0.9	-0.3	-0.5	-0.8	-0.5	0.5	0.9	-0.2	-0.2
Financial situation satisfaction	0.5	0.6	2.2	1.5	-0.0	-0.9	-0.3	-1.1	-0.9	0.3	-0.2	-0.9	0.2
Tinnitus: Yes, now most or all of the time	0.7	0.9	2.0	-0.9	-0.9	0.8	-1.4	0.8	-0.8	-0.2	-1.4	0.6	-0.9
Commuting to job workplace: Public transport	1.6	1.9	5.4	2.3	0.8	-2.0	0.0	-0.5	-0.4	1.0	0.1	-2.1	1.8
Eye problems/disorders: Glaucoma	0.3	0.4	0.9	0.7	-0.6	-0.8	0.6	0.1	0.6	-0.5	0.2	-0.9	0.8
Medication: Blood pressure	0.4	0.8	2.5	-0.0	-0.1	-0.5	-0.6	-1.5	-1.2	-0.8	0.2	-0.2	-1.6
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.5	0.9	1.9	-0.6	1.0	-0.6	-0.5	0.8	1.6	-0.5	0.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.1	1.0	-0.4	-1.0	0.4	-0.4	0.4	-0.3	-0.4	-1.1	0.7
High cholesterol (Self-reported)	1.4	2.5	5.2	2.3	-1.4	-2.2	-1.5	-1.3	-0.8	-0.6	-1.6	-2.2	0.9
Medication: Bendroflumethiazide	1.1	1.7	4.5	-0.7	-1.8	0.0	-1.7	-1.1	-1.0	-2.1	-1.0	0.2	-1.5
Medication: Paracetamol	0.3	0.5	1.3	-0.3	-0.9	0.0	0.1	-0.8	-0.9	-1.1	-0.8	0.2	-1.0
Medication: Lisinopril	0.3	0.4	1.4	-0.4	0.1	0.2	0.8	1.2	0.8	0.9	0.3	0.2	0.8
Medication: Atorvastatin	0.5	0.6	1.5	0.9	-0.9	-0.8	-0.7	-0.3	0.2	-0.2	-1.2	-0.8	0.8
Illnesses of father: High blood pressure	0.9	1.1	3.6	-1.4	0.1	1.9	0.1	0.9	0.2	0.8	0.1	1.9	-0.6
Alcohol drinker status: Never	0.9	1.1	2.7	0.9	0.3	-1.2	1.6	0.4	0.1	1.1	0.6	-1.2	1.5
Ever smoked	1.1	2.0	6.3	-1.0	-1.2	1.0	-2.5	-0.8	0.7	-2.0	-1.3	1.2	-1.5
Basal metabolic rate	0.6	3.5	6.8	-2.6	0.7	1.9	2.6	0.3	-2.0	1.0	1.9	2.1	-2.2
Leg fat percentage (left)	0.2	0.6	2.0	-1.1	-1.0	0.4	-0.8	0.1	0.1	-0.8	-1.4	0.5	-0.7
Arm fat-free mass (left)	0.7	3.5	9.5	-3.1	0.4	2.2	2.5	0.9	-1.1	0.6	1.6	2.4	-1.8
Number of operations (self-reported)	0.8	1.2	4.7	-0.1	-1.0	0.5	-2.2	0.6	1.3	-1.0	-1.7	0.5	0.1
Average weekly beer plus cider intake	1.1	1.5	3.7	-1.9	-0.5	1.4	1.8	1.6	1.4	-0.1	0.3	1.2	0.1
Irritability	0.6	1.0	3.2	-1.1	0.9	1.8	0.0	0.8	0.4	0.9	0.6	1.8	-0.3
Risk taking	0.1	0.1	0.4	0.3	0.6	-0.2	-0.5	-0.2	0.1	0.6	0.4	-0.1	-0.0
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.0	0.9	-0.6	-0.9	0.2	-0.1	-0.4	0.1	-0.9	-1.0	0.9
Fractured/broken bones in last 5 years	1.1	1.4	3.6	-1.9	-1.4	0.9	-0.6	-0.3	-0.4	-1.7	-0.4	1.0	-1.8
Age started oral contraceptive pill	0.2	0.3	0.8	0.7	0.3	-0.6	-0.3	-0.2	0.9	-0.2	-0.1	-0.6	0.9
Diastolic blood pressure, automated reading	0.3	0.8	2.5	0.4	-0.8	-0.2	-1.5	-0.6	0.2	-1.4	-1.6	-0.2	-0.3
Ever depressed for a whole week	1.8	2.3	4.8	0.4	1.3	0.8	1.6	1.8	2.2	2.0	1.1	0.6	2.0
Unable to work because of sickness or disability	0.7	0.9	3.4	0.7	-0.9	-0.6	-1.4	-1.1	-0.5	-0.6	-1.8	-0.5	-0.4
Commuting to job workplace: Cycle	0.5	0.6	0.9	1.0	0.7	-0.7	0.9	-0.1	-0.8	0.7	0.8	-0.7	0.9
Myopia	0.8	1.2	4.4	-0.9	0.5	0.7	0.4	1.7	2.1	0.7	0.1	0.6	1.4
Vascular/heart problems diagnosed by doctor	1.3	3.6	6.9	-1.0	2.2	1.7	2.4	2.1	0.8	2.6	2.4	1.7	0.8
Cholesterol lowering medication	0.9	1.3	4.0	0.8	-0.9	-0.1	-1.0	0.8	2.0	-0.4	-1.7	-0.2	1.7
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.0	1.7	-0.5	-1.7	-0.4	-1.4	-1.3	-0.4	-0.6	-1.7	0.4
Pain experienced in last month	0.9	1.5	5.3	-0.6	-1.8	0.2	-0.9	0.7	2.3	-1.5	-1.3	0.1	1.2
Supplements: Calcium	0.3	0.3	0.9	0.2	0.9	-0.4	0.9	0.3	0.4	0.6	0.5	-0.3	0.5
Basal cell carcinoma (self-reported)	2.2	2.6	6.9	2.5	-0.7	-2.6	-0.5	-1.8	-0.6	-0.6	-0.8	-2.6	1.0
Heart attack/myocardial infarction (self-reported)	2.8	3.7	10.0	0.6	-2.6	-0.5	-3.0	-1.7	-0.1	-2.4	-3.2	-0.4	-1.2
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	2.7	-1.5	0.8	1.4	0.1	0.3	-0.5	1.5	1.6	1.6	-1.4
Heart disease (siblings)	1.4	1.7	4.5	-0.5	-2.1	0.1	-1.6	-0.7	-0.7	-1.9	-2.0	0.0	-1.3
Alcohol drinker status: Previous	0.9	1.0	4.0	0.3	-0.5	-0.1	-2.0	-1.2	-1.2	-0.7	-0.6	-0.0	-1.3
Pack years of smoking	0.4	0.6	1.3	1.1	-0.2	-1.1	-0.1	-0.5	0.7	-0.8	-0.3	-1.1	0.9
Impedance of whole body	0.3	1.6	5.7	1.3	0.4	-0.1	-1.8	0.9	2.4	0.4	-0.9	-0.3	1.9
Leg fat mass (left)	0.3	1.1	3.8	-1.9	-0.6	1.1	0.3	0.1	-1.1	-0.3	-0.4	1.2	-1.7
Arm predicted mass (left)	0.8	3.9	10.2	-3.2	0.5	2.4	2.5	0.9	-1.3	0.7	1.6	2.6	-2.0