[Hub]/) : Traits : Age when periods started (menarche) :

chr16:68,901,284-70,725,815

Best TWAS P=1.7e-16 · Best GWAS P=3.77e-23 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex NOB1 0.04 0.05 enet 12 0.04 7.2e-06 -6.1 6.1 1.1e-09 0.69 0.61 0.38 FALSE
2 GTEx Adipose Subcutaneous NFAT5 0.09 0.02 enet 19 0.05 8.2e-05 -5.4 -7.7 1.5e-14 -0.55 0.02 0.91 TRUE
3 GTEx Brain Cerebellar Hemisphere PDXDC2P 0.33 0.16 enet 11 0.27 1.4e-07 6.4 5.3 1.1e-07 0.46 0.54 0.19 TRUE
4 GTEx Brain Nucleus accumbens basal ganglia PDXDC2P 0.26 0.17 lasso 5 0.13 2.2e-04 5.4 5.2 2.4e-07 0.44 0.34 0.05 TRUE
5 GTEx Testis WWP2 0.30 0.10 lasso 5 0.16 9.2e-08 -5.3 -6.1 1.4e-09 -0.53 0.66 0.03 TRUE
6 GTEx Thyroid NOB1 0.03 0.01 enet 6 0.02 7.7e-03 -6.4 6.8 1.4e-11 0.73 0.18 0.43 FALSE
7 GTEx Thyroid CTD-2033A16.3 0.03 0.02 enet 7 0.02 6.7e-03 -1.7 5.2 2.3e-07 0.66 0.18 0.36 FALSE
8 METSIM Adipose NOB1 0.03 0.03 lasso 2 0.03 2.8e-05 -5.7 6.7 1.8e-11 0.76 0.07 0.92 FALSE
9 METSIM Adipose WWP2 0.08 0.04 enet 19 0.07 2.7e-10 7.7 8.2 1.7e-16 0.69 0.66 0.34 TRUE
10 The Cancer Genome Atlas Breast Invasive Carcinoma CLEC18A 0.16 0.17 enet 10 0.19 6.8e-37 6.5 5.8 7.9e-09 0.50 0.96 0.04 FALSE
11 The Cancer Genome Atlas Breast Invasive Carcinoma NFAT5 0.02 0.01 enet 5 0.01 6.6e-04 -5.0 -7.5 6.2e-14 -0.73 0.02 0.48 TRUE
12 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CLEC18A 0.10 0.06 lasso 2 0.04 6.3e-03 6.5 6.5 1.0e-10 0.52 0.04 0.20 FALSE
13 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma PDXDC2 0.20 0.02 blup 26 0.07 1.8e-04 5.4 5.5 3.6e-08 0.42 0.06 0.33 FALSE
14 The Cancer Genome Atlas Colon Adenocarcinoma CLEC18A 0.14 0.18 lasso 5 0.15 4.5e-09 6.5 6.7 1.9e-11 0.55 0.41 0.59 FALSE
15 The Cancer Genome Atlas Glioblastoma Multiforme PDXDC2 0.10 0.12 lasso 3 0.10 4.7e-04 6.5 6.5 1.0e-10 0.52 0.01 0.85 FALSE
16 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CLEC18A 0.20 0.12 lasso 3 0.15 2.7e-16 6.3 5.2 2.4e-07 0.44 0.98 0.02 FALSE
17 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PDXDC2 0.14 0.05 enet 6 0.05 3.2e-06 5.4 5.2 2.3e-07 0.43 0.14 0.84 FALSE
18 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CLEC18C 0.06 0.05 lasso 1 0.04 3.8e-05 5.4 5.4 7.1e-08 0.44 0.65 0.12 FALSE
19 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PDXDC2 0.03 0.04 enet 4 0.04 4.0e-05 5.4 5.4 6.1e-08 0.45 0.19 0.70 FALSE
20 The Cancer Genome Atlas Brain Lower Grade Glioma PDXDC2 0.15 0.25 enet 12 0.29 8.2e-33 5.4 5.5 5.0e-08 0.45 0.14 0.86 FALSE
21 The Cancer Genome Atlas Lung Adenocarcinoma CLEC18A 0.13 0.17 enet 11 0.17 1.8e-19 6.5 5.8 4.9e-09 0.48 0.97 0.03 FALSE
22 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CLEC18A 0.06 0.10 lasso 1 0.09 6.9e-11 6.4 6.4 2.0e-10 0.52 0.94 0.06 FALSE
23 The Cancer Genome Atlas Pancreatic Adenocarcinoma NOB1 0.13 0.01 blup 35 0.03 1.8e-02 -3.7 -7.7 1.6e-14 -0.53 0.01 0.32 FALSE
24 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma CLEC18A 0.20 0.14 enet 12 0.15 1.5e-06 6.4 5.6 2.2e-08 0.47 0.51 0.24 FALSE
25 The Cancer Genome Atlas Rectum Adenocarcinoma CLEC18A 0.15 0.03 blup 23 0.09 4.3e-03 5.4 6.7 2.1e-11 0.63 0.01 0.41 FALSE
26 The Cancer Genome Atlas Soft Tissue Sarcoma CLEC18A 0.12 0.11 lasso 2 0.11 3.4e-07 6.6 6.6 3.1e-11 0.55 0.62 0.36 FALSE
27 The Cancer Genome Atlas Soft Tissue Sarcoma PDXDC2 0.05 0.01 blup 26 0.03 9.5e-03 5.4 6.3 3.8e-10 0.52 0.02 0.54 FALSE
28 The Cancer Genome Atlas Skin Cutaneous Melanoma CLEC18A 0.17 0.09 enet 8 0.11 8.5e-04 5.4 7.2 6.6e-13 0.63 0.01 0.83 FALSE
29 The Cancer Genome Atlas Stomach Adenocarcinoma CLEC18A 0.07 0.05 blup 23 0.04 3.7e-04 6.4 5.9 2.8e-09 0.48 0.20 0.28 FALSE
30 The Cancer Genome Atlas Testicular Germ Cell Tumors CLEC18A 0.20 0.09 lasso 5 0.08 8.8e-04 7.7 7.7 1.5e-14 0.70 0.00 0.93 FALSE
31 The Cancer Genome Atlas Thyroid Carcinoma CLEC18A 0.24 0.26 blup 23 0.27 1.3e-26 6.4 5.5 4.5e-08 0.45 0.98 0.02 TRUE