Hub : Genes

STAT2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1100	0.0370	3.1e-05	0.069	NA	0.051	NA	0.050	2.8e-06	NA	4.9e-05	NA	6.1e-05
2	GTEx	Liver	0.3230	0.0970	8.9e-05	0.166	NA	0.062	NA	0.141	2.2e-05	NA	8.4e-03	NA	9.9e-05
3	GTEx	Nerve Tibial	0.0817	0.0406	8.5e-03	0.046	NA	0.015	NA	0.027	3.4e-04	NA	2.6e-02	NA	5.0e-03
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0670	0.0470	1.8e-03	0.042	0.040	0.042	NA	0.035	1.9e-03	0.0023	1.9e-03	NA	4.4e-03
5	TCGA	Lung Adenocarcinoma	0.0163	0.0113	3.1e-03	0.016	0.013	0.007	NA	0.008	5.2e-03	0.0096	4.0e-02	NA	3.2e-02
6	TCGA	Testicular Germ Cell Tumors	0.3280	0.1310	6.3e-03	0.004	0.044	0.055	NA	0.002	2.2e-01	0.0120	5.0e-03	NA	2.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.0	0.0	0.2	0.4	-0.1	-0.2	0.1	-0.0	0.0
Bipolar Disorder or Schizophrenia	1.2	2.8	5.1	1.9	-2.0	1.7	-1.2	-2.2	-0.2
Depressed Affect (Nagel 2018)	2.1	4.4	5.9	2.1	-2.4	2.0	-1.6	-2.4	-1.8
Depression (Nagel 2018)	1.0	1.5	3.2	1.8	-1.3	1.0	-0.9	-1.5	0.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.3	0.7	0.1	-0.4	1.2	0.2	-0.3
Neuroticism (Nagel 2018)	0.4	1.0	1.6	0.3	-1.3	1.0	-1.1	-1.0	-1.1
Schizophrenia (2018)	2.3	4.8	7.7	2.1	-2.5	2.3	-1.8	-2.8	-1.5
Schizophrenia vs Biploar Disorder	0.9	1.2	2.2	0.5	-1.3	1.2	-0.7	-1.5	-1.1
Worry (Nagel 2018)	0.4	0.8	1.9	-0.4	-1.1	0.9	-1.4	-0.8	-0.3
Alzheimer’s Disease (in mother)	0.3	0.4	0.9	0.4	-0.9	0.7	-0.3	-0.9	-0.2
Alzheimer’s Disease (in father)	0.5	0.6	0.8	-0.8	0.9	-0.7	0.5	0.9	0.6
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	-0.6	0.3	-0.2	0.6	0.2	0.4
Crohns Disease (2017)	0.1	0.2	0.4	0.6	-0.2	0.0	0.3	-0.4	-0.6
Irritable Bowel Disease (IBD)	0.1	0.1	0.3	0.4	-0.3	0.1	0.1	-0.5	-0.5
Ulcerative Colitis (UC)	0.1	0.1	0.4	0.5	-0.0	-0.1	0.5	-0.1	-0.6
Major Depression (MDD)	0.2	0.3	0.6	0.2	-0.5	0.8	-0.6	-0.6	0.0
Reaction Time	1.3	2.4	3.7	-1.7	1.8	-1.9	1.3	1.7	0.8
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	0.7	-0.5	0.1	0.7	-0.1	-0.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.5	0.6	1.9	-0.0	1.4	-0.8	0.4	0.9	-0.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.5	0.7	3.0	0.7	0.6	-0.5	0.1	0.1	1.7
Bipolar Disorder (2011)	0.1	0.1	0.6	0.0	0.0	0.0	-0.5	-0.8	0.0
Body Mass Index (BMI) (2010)	0.9	1.2	2.0	0.6	-1.1	1.4	-1.1	-1.4	-0.9
Coronary Artery Disease (CAD)	2.1	2.6	3.8	1.4	-1.8	1.6	0.0	-1.9	-1.9
Crohns Disease (2012)	0.1	0.1	0.3	0.5	-0.3	0.1	-0.3	-0.2	0.4
Mean Putamen Volume	0.5	0.6	1.0	0.3	-0.8	1.0	-0.9	-0.6	0.9
Fasting Glucose	0.8	1.0	1.7	-0.5	1.2	-1.3	1.0	1.1	0.5
HbA1C	0.9	1.0	2.2	-0.4	-1.1	1.5	-0.3	-1.2	-1.0
HDL Cholesterol	0.5	0.8	1.3	-1.1	0.9	-1.1	0.6	0.9	0.3
LDL Cholesterol	0.2	0.4	1.4	-1.2	0.4	-0.4	0.4	0.2	-0.4
Lupus	1.6	2.4	3.3	-1.5	1.6	-1.8	1.3	1.5	1.5
Neuroticism (2016)	0.7	1.1	1.9	1.2	-0.7	1.2	-0.5	-0.9	-1.4
Primary Biliary Cirrhosis	2.1	3.0	5.8	1.1	-2.2	2.2	-1.3	-2.4	0.0
Rheumatoid Arthritis	0.4	0.5	2.9	-1.7	0.1	0.2	-0.1	0.0	0.2
Schizophrenia (2014)	0.8	1.9	3.3	1.3	-1.6	1.4	-0.8	-1.8	-1.0
Triglycerides	0.7	1.1	1.8	-0.8	1.1	-1.3	1.3	1.3	-0.1
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	-0.1	-0.5	-0.3	0.6	0.3	0.6
Ulcerative Colitis	0.8	1.2	2.0	-1.0	1.4	-1.2	1.1	1.2	-0.5
Blood Eosinophil Count	0.0	0.3	0.5	0.5	0.4	-0.3	0.4	0.7	0.6
Blood Platelet Count	0.6	7.1	9.1	2.9	2.9	-3.0	2.9	2.7	-0.3
Blood Red Count	3.5	34.0	47.0	3.6	-6.7	6.7	-6.1	-6.9	-4.0
Blood White Count	0.4	3.1	5.5	0.7	-2.0	2.0	-1.5	-2.3	-1.6
Heel T-Score	0.7	5.3	16.0	4.0	-2.2	2.1	-1.5	-2.1	0.5
BMI	0.4	2.2	7.5	-1.0	-0.9	1.0	-1.4	-1.1	-2.7
Height	5.0	96.5	137.4	-6.5	11.5	-11.3	9.7	11.7	6.7
Waist Hip Ratio (WHR)	0.8	3.4	5.1	-1.6	2.0	-2.0	2.2	2.3	0.3
Systolic Blood Pressure	0.0	0.2	0.6	0.2	0.2	0.1	0.7	0.1	-0.8
Smoking Status	1.3	3.1	4.6	-2.2	1.9	-2.0	1.5	2.0	-0.3
Allergy or Eczema	0.7	1.9	3.9	0.2	1.4	-1.3	1.4	2.0	1.3
Cardiovascular Disease	1.0	3.3	4.3	2.1	-1.8	1.8	-1.2	-1.9	-2.0
Hypothyroidism (self reported)	1.1	2.5	8.3	2.9	-1.1	1.0	-0.9	-1.2	1.5
Respiratory disease	0.3	0.8	2.3	1.5	0.7	-0.7	0.9	0.6	-0.2
Type 2 Diabetes (T2D) (2018)	2.2	4.1	12.5	1.9	-1.5	1.6	-0.8	-1.6	-3.5
Lung FEV1/FVC ratio	0.1	0.7	3.8	-1.9	-0.1	-0.1	-0.7	0.0	0.2
Lung FVC	2.2	11.0	21.5	-4.6	3.4	-3.2	3.7	3.0	0.1
Neuroticism	0.2	0.5	2.2	-0.2	-0.6	0.4	-0.4	-0.4	-1.5
Chronotype (morning person)	3.9	8.9	11.7	-2.9	3.2	-3.0	3.3	3.4	1.7
Hair Pigment	0.0	0.7	1.8	-1.2	-0.1	0.1	0.8	-0.4	-1.4
Tanning	0.6	7.4	11.2	-1.4	3.2	-3.1	2.5	3.3	2.1
Hand grip strength (left)	0.4	1.0	1.7	-1.3	1.1	-1.0	0.8	1.1	0.1
Number of treatments/medications taken	0.8	1.5	2.9	-1.7	0.9	-1.2	1.5	0.8	-0.9
Average weekly spirits intake	2.7	3.3	4.6	2.0	-1.8	1.6	-1.0	-2.1	-2.1
Sensitivity / hurt feelings	0.2	0.3	0.9	-0.9	-0.6	0.5	-0.3	-0.6	-0.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	0.8	-0.4	0.3	-0.5	-0.6	-0.0
Hearing difficulty/problems: Yes	0.3	0.5	2.7	0.2	-0.2	0.2	0.3	-0.2	-1.6
Relative age of first facial hair	0.5	1.0	1.2	0.8	-1.1	1.1	-1.1	-0.9	1.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.6	0.1	0.5	-0.4	0.8	0.4	0.3
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	-0.2	0.5	-0.6	0.4	0.5	-0.4
Ever had hysterectomy (womb removed)	0.7	0.7	1.2	-0.4	1.0	-1.0	0.8	1.1	0.7
Systolic blood pressure, automated reading	0.0	0.0	0.1	-0.2	0.1	-0.1	0.2	0.3	-0.1
Eye problems/disorders: Diabetes related eye disease	3.1	3.4	5.3	2.3	-2.1	1.9	-1.9	-1.8	-0.1
Angina	0.5	0.7	2.0	0.5	-0.6	0.9	-0.7	-1.4	0.4
Medication for hormone replacement therapy	0.1	0.2	0.3	0.2	0.3	-0.4	-0.5	0.6	0.4
Vitamin and mineral supplements	0.3	0.4	0.5	0.5	-0.7	0.7	-0.7	-0.4	-0.5
Supplements: Zinc	2.4	2.6	4.5	0.6	1.5	-1.9	1.1	2.0	2.1
Medication: Co-codamol	0.8	1.0	3.1	-1.8	0.8	-1.0	0.6	0.8	-0.0
Medication: Metformin	0.5	0.6	1.9	1.1	0.2	-0.3	0.7	0.4	-1.4
Diabetes (father)	0.5	0.6	2.4	-1.5	0.7	-0.6	0.4	0.5	-0.4
Diabetes (mother)	0.3	0.4	0.8	0.2	-0.5	0.9	-0.7	-0.6	-0.3
Severe depression (siblings)	0.2	0.2	0.3	0.5	0.3	-0.5	0.4	0.3	0.4
Pack years adult smoking proportion	2.2	3.4	4.9	0.5	-2.1	2.1	-1.4	-2.2	-2.0
Impedance of leg (right)	0.6	2.7	6.7	2.6	-1.1	0.8	-1.0	-0.8	2.4
Leg fat-free mass (left)	1.9	9.9	14.9	-3.9	3.6	-3.4	2.8	3.4	-0.6
Trunk fat percentage	0.2	0.9	1.5	0.5	-0.9	1.1	-0.9	-0.9	-1.2
Hand grip strength (right)	0.2	0.6	1.2	-1.1	0.8	-0.7	0.4	0.9	-0.2
Townsend deprivation index at recruitment	2.1	3.0	3.8	-1.9	2.0	-1.9	1.8	1.9	-0.2
Current tobacco smoking	0.3	0.5	1.3	1.2	-0.8	0.7	-0.1	-0.6	-0.4
Average weekly fortified wine intake	0.3	0.3	0.8	0.8	0.2	-0.4	-0.4	0.3	0.9
Maternal smoking around birth	0.5	0.7	2.1	0.3	0.8	-0.8	1.4	0.3	-1.0
Fed-up feelings	1.7	3.1	6.5	1.2	-1.9	1.5	-1.4	-1.7	-2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	7.4	-0.3	-0.1	-0.1	0.4	-0.2	-2.7
Relative age voice broke	0.2	0.4	0.8	-0.1	-0.7	0.9	-0.9	-0.5	0.2
Taking other prescription medications	0.3	0.5	1.2	0.1	0.7	-0.7	1.1	0.7	0.3
Age when periods started (menarche)	0.3	0.7	1.0	-0.5	0.9	-0.9	0.7	0.9	1.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	0.6	0.2	-0.3	0.1	0.6	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.2	0.1	-1.0	1.0	-0.6	-1.1	0.6
Tinnitus: Yes, but not now, but have in the past	2.0	2.2	3.9	-1.1	1.7	-1.7	2.0	1.2	-1.0
Qualifications: CSEs or equivalent	0.7	0.9	2.5	-1.1	-0.8	0.8	-1.6	-0.8	-0.1
Serious illness, injury or assault to yourself	4.2	5.1	7.5	1.7	-2.6	2.7	-2.3	-2.7	-1.1
High blood pressure	0.1	0.3	1.0	0.3	0.4	-0.5	1.0	0.1	-0.3
Hayfever, allergic rhinitis or eczema	0.8	1.7	4.3	-0.4	1.5	-1.4	0.9	2.1	0.9
Multivitamins +/- minerals	0.0	0.0	0.1	0.0	0.3	-0.3	0.0	0.1	0.2
Stomach or abdominal pain in last month	2.2	2.8	5.3	0.3	-2.3	1.6	-2.1	-1.8	-1.0
Supplements: Glucosamine	1.5	2.0	4.8	-2.2	1.3	-1.1	1.3	1.0	-1.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.4	-0.6	0.3	-0.1	-0.6	0.2	-0.3
Medication: Atenolol	0.1	0.1	0.2	-0.0	0.5	-0.3	0.2	0.2	-0.2
Medication: Levothyroxine sodium	0.7	1.2	3.1	1.8	-1.1	1.0	-0.8	-1.0	0.5
Sitting height	1.8	13.1	18.9	-2.4	4.3	-4.3	3.9	4.3	1.2
Chronic bronchitis/emphysema (father)	0.6	0.7	1.1	1.1	-0.9	0.8	-0.2	-0.8	-0.8
High blood pressure (mother)	0.2	0.3	0.6	0.7	0.1	-0.2	0.4	0.6	0.8
Body mass index (BMI)	0.5	2.2	8.9	-1.2	-0.7	0.9	-0.8	-1.0	-3.0
Impedance of leg (left)	0.5	2.5	6.9	2.6	-1.1	0.8	-0.9	-0.7	2.2
Leg predicted mass (left)	1.9	10.1	15.3	-3.9	3.7	-3.4	2.8	3.4	-0.5
Trunk fat mass	0.1	0.4	0.9	-0.9	0.6	-0.4	0.3	0.5	-1.0
Waist circumference	0.4	1.4	2.5	-1.6	1.0	-0.9	1.0	0.9	-1.4
Number of incorrect matches in round	1.1	1.8	3.6	-1.9	1.2	-1.5	1.6	0.9	0.2
Past tobacco smoking	6.7	12.4	16.8	4.1	-3.9	3.9	-3.3	-3.9	-0.9
Alcohol usually taken with meals	0.8	1.3	6.4	0.3	0.3	-0.3	-0.7	0.7	2.5
Nervous feelings	0.3	0.5	0.7	-0.3	-0.9	0.9	-0.8	-0.8	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.6	0.2	-1.0	1.0	-1.3	-1.1	0.2
Hearing difficulty/problems with background noise	0.8	1.3	2.2	-1.5	0.9	-1.3	1.2	1.2	0.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.3	-0.2	-0.2	0.5	-0.0	-0.3
Had menopause	2.0	2.5	5.4	1.1	-1.6	1.8	-2.3	-1.5	-0.3
Had other major operations	0.6	0.8	1.2	0.9	0.8	-1.0	0.9	1.1	0.4
Forced vital capacity (FVC)	5.8	22.2	30.7	-4.5	5.4	-5.3	4.6	5.5	1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.7	0.0	-1.3	1.1	-0.5	-1.2	-0.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.8	-0.1	-0.7	0.6	-0.4	-0.6	-0.9
Qualifications: None of the above	2.1	4.5	9.7	-3.1	2.1	-2.2	2.0	1.8	0.9
Financial difficulties in last 2 years	2.2	2.9	9.7	-0.1	-1.4	1.3	-0.6	-1.9	-3.1
Mouth/teeth dental problems	0.2	0.4	2.0	1.4	-0.2	0.2	-0.2	-0.1	0.3
Heart attack	1.7	2.1	4.0	0.9	-1.5	1.4	-2.0	-1.7	0.7
Allergy	0.1	0.2	0.6	-0.4	-0.4	0.3	-0.1	-0.8	-0.1
Pain all over the body in last month	0.7	0.7	2.0	0.8	-0.7	0.8	-1.4	-0.8	0.1
Diabetes (self-reported)	2.5	3.9	8.2	2.5	-1.7	1.6	-1.0	-1.7	-2.9
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	5.0	-0.2	1.6	-1.6	1.8	2.2	0.5
Medication: Ramipril	0.2	0.2	0.6	0.8	-0.3	0.5	-0.6	-0.3	0.0
Medication: Simvastatin	2.9	4.2	5.2	1.9	-2.2	2.2	-2.0	-2.3	-1.6
Fluid intelligence score	0.2	0.4	1.4	1.2	-0.6	0.5	-0.2	-0.5	0.0
Illnesses of siblings	0.8	1.1	1.8	1.3	-1.0	0.9	-1.1	-0.7	1.0
Neuroticism score	0.4	0.8	3.2	-0.3	-0.8	0.6	-0.4	-0.7	-1.8
Weight	1.2	5.8	9.1	-3.0	2.8	-2.5	2.1	2.6	-1.0
Impedance of arm (right)	0.4	2.0	6.0	2.4	-0.9	0.7	-0.3	-0.4	2.2
Arm fat percentage (right)	0.4	1.7	4.5	-0.3	-1.2	1.3	-1.1	-1.2	-2.1
Trunk fat-free mass	4.1	23.5	33.0	-5.1	5.7	-5.5	4.3	5.6	1.4
Hip circumference	0.1	0.4	0.9	-0.8	0.5	-0.5	0.3	0.6	-1.0
Time employed in main current job	0.8	0.9	1.4	0.5	-1.2	1.1	-1.0	-1.2	0.3
Alcohol intake versus 10 years previously	1.4	2.2	2.9	-1.6	1.6	-1.7	1.4	1.6	0.0
Father’s age at death	0.5	0.7	1.1	-0.4	0.9	-0.8	1.1	0.9	0.9
Worrier / anxious feelings	0.8	1.6	3.2	0.8	-1.4	1.4	-1.8	-1.3	-0.3
Frequency of tiredness / lethargy in last 2 weeks	3.3	5.3	7.3	2.3	-2.5	2.4	-2.0	-2.7	-1.8
Falls in the last year	1.8	2.4	5.3	0.7	-1.8	1.8	-1.4	-2.3	-0.8
Hair/balding pattern: Pattern 3	0.0	0.1	0.3	0.2	0.1	-0.2	0.2	0.1	0.5
Number of live births	0.2	0.2	0.5	0.2	0.7	-0.5	0.6	0.5	-0.1
Forced expiratory volume in 1-second (FEV1)	3.8	12.7	17.9	-4.2	3.9	-3.8	3.2	4.0	1.5
Pulse rate	0.8	1.3	2.4	1.6	-1.1	1.2	-1.1	-1.2	-0.1
Happiness	0.2	0.3	0.8	0.9	-0.5	0.5	-0.1	-0.6	-0.3
Noisy workplace	0.3	0.4	0.8	-0.4	0.4	-0.5	0.8	0.3	0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.4	1.5	-0.8	0.6	-0.3	-0.2	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.2	0.1	-1.1	1.1	-1.5	-1.0	0.2
Mouth/teeth dental problems: Dentures	0.8	1.3	2.9	0.5	-1.2	1.2	-1.7	-1.1	-0.6
Asthma	0.2	0.5	1.9	1.4	-0.2	0.2	0.1	-0.3	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.7	-0.4	0.8	-1.0	1.3	0.9	-1.1
Medication: Cholesterol lowering	2.2	3.4	4.6	1.7	-1.9	1.8	-2.0	-2.1	-1.4
Depression (self-reported)	2.6	3.1	9.2	0.9	-1.5	1.5	-0.9	-1.8	-3.0
Medication: Lansoprazole	0.5	0.6	1.2	1.1	-0.7	0.7	-0.6	-0.8	-0.2
Prospective memory result	0.3	0.3	0.6	-0.2	0.7	-0.6	0.8	0.6	-0.3
Lung cancer (father)	1.9	2.2	3.5	1.2	-1.5	1.4	-1.6	-1.9	1.2
Illnesses of mother	0.2	0.2	0.8	-0.8	0.2	-0.1	-0.1	-0.0	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	6.9	21.9	27.6	-5.1	5.2	-5.1	4.5	5.3	1.9
Pulse wave Arterial Stiffness index	2.1	2.5	4.2	-0.1	1.5	-1.6	2.0	1.8	-1.7
Impedance of arm (left)	0.6	2.7	8.7	2.9	-1.2	1.0	-0.6	-0.8	2.0
Arm fat mass (right)	0.3	1.2	4.0	-1.7	0.4	-0.3	0.3	0.3	-2.0
Trunk predicted mass	4.1	23.6	33.1	-5.1	5.8	-5.5	4.3	5.6	1.3
Standing height	4.7	47.0	68.6	-4.5	8.1	-8.0	6.7	8.3	4.5
Length of working week for main job	0.2	0.3	1.5	-0.3	-0.1	0.0	0.1	-0.1	-1.2
Exposure to tobacco smoke at home	0.2	0.2	0.3	-0.3	0.6	-0.3	-0.1	0.5	0.5
Breastfed as a baby	0.3	0.3	1.0	1.0	0.1	-0.3	0.2	0.6	0.6
Tense / ‘highly strung’	0.4	0.7	1.7	-1.3	-0.5	0.4	0.2	-0.5	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.5	-0.6	1.1	-1.6	1.2	1.4	-0.7
Hair/balding pattern: Pattern 4	4.8	11.7	17.8	-1.9	3.9	-4.1	3.7	4.2	2.0
Birth weight of first child	0.1	0.2	0.6	0.6	0.3	-0.5	0.8	0.2	0.2
Peak expiratory flow (PEF)	0.5	1.2	1.7	-1.3	1.1	-1.1	0.4	1.2	1.1
Pulse wave reflection index	0.9	1.1	2.3	-0.4	1.0	-1.3	1.5	1.2	-0.7
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	-0.3	0.3	-0.4	0.6	0.6	-0.7
Loud music exposure frequency	1.1	1.2	3.9	-1.2	-0.8	0.9	0.0	-0.7	-2.0
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	6.3	2.5	-1.2	1.1	-1.0	-1.2	-1.5
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.3	-1.8	0.8	-0.7	0.9	0.4	-0.2
Blood clot in the leg (DVT)	0.4	0.5	1.6	-1.3	-0.1	0.0	0.1	-0.0	-1.3
Medication: Paracetamol	0.5	0.9	4.4	-0.8	-0.2	0.1	0.4	-0.5	-2.1
Headache pain in last month	0.0	0.1	0.2	-0.0	-0.2	0.2	-0.4	-0.2	-0.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.8	0.4	-1.0	1.2	-1.3	-0.8	0.4
Glaucoma (self-reported)	4.5	5.3	7.4	-2.0	2.4	-2.7	2.7	2.6	0.7
Gout (self-reported)	2.3	3.1	4.0	-1.9	1.8	-2.0	2.0	2.0	-0.0
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	5.1	2.2	-0.9	0.8	-0.7	-0.9	1.1
Medication: Amlodipine	1.3	1.8	2.6	-0.9	1.6	-1.6	1.1	1.4	1.4
Medication: Ventolin 100micrograms inhaler	1.2	1.5	2.8	1.7	-1.1	1.1	-1.0	-0.9	-1.4
Birth weight	0.5	1.0	2.8	0.9	0.9	-0.9	0.1	0.9	1.7
Chronic bronchitis/emphysema (mother)	1.9	2.2	3.3	-0.6	1.7	-1.8	1.6	1.8	0.9
High blood pressure (siblings)	0.8	1.2	3.9	-2.0	1.1	-0.7	0.8	0.8	-0.2
Forced vital capacity (FVC), Best measure	8.6	31.5	41.7	-5.2	6.3	-6.3	5.9	6.5	2.4
Body fat percentage	0.5	1.9	2.6	0.6	-1.4	1.5	-1.4	-1.5	-1.6
Leg fat percentage (right)	0.8	3.0	4.3	0.7	-1.9	1.9	-2.1	-2.0	-1.4
Arm fat-free mass (right)	2.7	14.1	20.1	-4.2	4.5	-4.2	3.3	4.2	0.0
Exposure to tobacco smoke outside home	0.3	0.3	1.6	-1.3	0.2	-0.0	-0.1	-0.2	-0.6
Comparative body size at age 10	0.4	1.1	3.8	0.5	-0.9	0.9	-1.9	-0.7	-0.8
Number of full brothers	0.1	0.2	0.3	-0.3	-0.2	0.5	-0.4	-0.5	-0.3
Worry too long after embarrassment	0.4	0.6	1.0	1.0	-1.0	1.0	-0.7	-0.7	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	5.2	0.5	0.1	-0.2	0.5	0.0	-2.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.7	0.5	-0.1	0.0	0.4	-0.2	-0.8
Number of children fathered	10.2	11.5	16.1	-3.2	4.0	-3.9	3.4	3.9	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.1	0.2	0.2	-0.2	0.2	-0.2	0.0	-0.4
Age at first live birth	1.0	1.9	8.5	2.9	-1.2	0.6	-0.6	-0.8	0.2
Pulse wave peak to peak time	1.4	1.7	3.6	-0.1	-1.1	1.1	-1.6	-1.3	1.9
Health satisfaction	2.1	2.7	3.8	1.6	-1.8	1.7	-1.2	-1.9	-1.5
Shortness of breath walking on level ground	2.4	2.8	4.2	1.8	-1.9	1.8	-1.3	-2.1	-1.0
Qualifications: College or University degree	0.1	0.4	1.3	1.1	0.3	-0.2	-0.2	0.9	-0.0
Eye problems/disorders: None of the above	0.5	0.6	3.3	-0.4	0.0	0.1	0.5	0.1	-1.8
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.4	0.1	-0.5	0.5	-0.3	-0.6	0.1
Emphysema/chronic bronchitis	0.7	0.8	2.3	1.5	-0.3	0.8	-1.1	-0.5	-0.4
Medication for pain relief, constipation, heartburn	0.6	1.0	2.6	-0.2	0.9	-0.8	0.9	1.0	1.6
Neck or shoulder pain in last month	0.2	0.3	1.2	-1.1	-0.1	0.0	-0.3	-0.1	-0.6
Medication: Blood pressure	2.2	3.9	5.8	-1.2	2.3	-2.3	2.4	2.0	1.0
Angina (self-reported)	0.5	0.7	2.0	0.6	-0.6	0.8	-0.5	-1.4	0.5
Migraine (self-reported)	1.6	1.9	3.0	-1.6	1.2	-1.4	0.6	1.5	1.7
Medication: Ibuprofen	1.4	1.6	3.3	-0.6	1.2	-1.4	1.8	1.4	-1.1
Medication: Allopurinol	4.1	5.5	7.4	-2.4	2.3	-2.7	2.5	2.7	0.9
Medication: Omeprazole	0.1	0.1	0.4	-0.3	-0.1	0.2	-0.7	-0.2	-0.4
Medication: Seretide 50 evohaler	0.9	1.1	1.6	0.5	-1.2	1.1	-1.3	-1.2	-0.7
Mean time to correctly identify matches	1.3	2.4	3.8	-1.4	1.9	-1.9	1.3	1.6	0.9
Heart disease (mother)	0.6	0.8	2.6	-0.2	0.7	-0.7	0.6	0.7	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.9	-0.7	0.8	-0.5	0.9	0.4	-0.1
Whole body fat mass	0.2	0.8	2.2	-1.3	0.6	-0.5	0.4	0.5	-1.5
Leg fat mass (right)	0.2	0.7	2.7	-1.1	0.1	0.0	-0.2	-0.1	-1.6
Arm predicted mass (right)	2.1	10.6	15.4	-3.9	3.9	-3.6	2.8	3.5	-0.2
Pulse rate, automated reading	1.1	3.5	5.0	0.8	-2.0	1.9	-1.7	-2.2	-2.2
Alcohol intake frequency.	1.0	2.2	3.3	1.4	-1.5	1.4	-1.8	-1.7	-1.1
Comparative height size at age 10	1.8	9.8	13.6	-1.6	3.5	-3.7	2.9	3.7	2.9
Number of full sisters	0.5	0.6	2.2	-1.5	0.7	-0.5	0.6	0.5	-0.0
Suffer from ‘nerves’	0.8	1.3	3.5	-1.9	0.9	-1.1	0.6	1.1	-0.8
Overall health rating	2.1	4.4	7.0	0.1	-2.5	2.2	-1.8	-2.7	-2.3
Chest pain or discomfort	1.6	2.2	2.8	1.5	-1.5	1.3	-1.3	-1.7	-1.6
Had major operations	2.6	3.1	4.4	-1.9	1.8	-2.0	2.1	1.7	0.5
Age at last live birth	0.5	0.8	3.4	1.9	-0.7	0.5	-0.1	-0.6	0.0
Family relationship satisfaction	3.1	3.8	7.1	-1.7	2.1	-2.1	2.7	1.9	-0.6
Leg pain on walking	0.0	0.0	0.2	-0.2	0.2	-0.2	0.4	0.1	-0.0
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.2	1.0	-1.0	1.3	-1.0	-1.5	-0.4
Commuting to job workplace: Car/motor vehicle	2.1	2.4	3.5	1.9	-1.7	1.6	-1.6	-1.7	-0.3
Illness, injury, bereavement, stress in last 2 years	3.5	4.3	6.9	-0.7	2.5	-2.3	1.9	2.6	1.8
Medication: Aspirin	0.5	0.7	1.4	0.7	-0.8	0.8	-1.2	-1.0	0.2
Supplements: Vitamin C	0.1	0.2	0.7	-0.0	-0.2	0.2	0.3	-0.4	0.8
Knee pain experienced in last month	0.9	1.3	2.7	-1.2	1.0	-1.1	1.6	0.9	-0.9
Hypertension (Self-reported)	0.1	0.4	1.1	0.2	0.5	-0.6	1.1	0.3	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.1	-0.1	-1.4	1.4	-1.8	-1.3	0.2
Illnesses of father: Heart disease	0.8	1.2	1.8	0.1	-1.3	1.0	-0.9	-1.3	-1.4
Illnesses of siblings: Diabetes	0.8	1.0	4.2	0.6	-0.7	0.6	-0.1	-0.7	-2.0
Smoking status: Previous	4.9	7.3	13.3	-3.6	2.9	-3.0	2.0	2.9	0.8
Forced expiratory volume in 1-second (FEV1), predicted	9.6	20.0	27.5	-3.5	5.2	-5.2	4.7	5.2	2.2
Whole body fat-free mass	3.1	17.9	24.9	-4.7	5.0	-4.7	3.8	4.8	0.5
Leg fat-free mass (right)	2.0	10.5	15.4	-3.9	3.8	-3.5	3.0	3.5	-0.5
Arm fat percentage (left)	0.7	2.8	5.5	0.4	-1.6	1.7	-1.6	-1.7	-2.4
Average weekly red wine intake	1.1	1.7	2.9	1.0	-1.7	1.5	-1.3	-1.4	0.6
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.0	0.7	-1.6	1.5	-1.7	-1.4	-0.1
Mood swings	0.5	0.9	2.7	0.3	-1.0	0.7	-0.3	-1.0	-1.6
Loneliness, isolation	0.8	1.0	2.4	-0.4	-1.1	0.9	-0.9	-0.9	-1.5
Long-standing illness, disability or infirmity	0.5	0.8	1.6	1.0	-0.9	0.6	-0.2	-0.8	-1.3
Ever had bowel cancer screening	2.7	3.2	5.9	-1.2	2.4	-1.9	1.5	2.4	-0.5
Diabetes diagnosed by doctor	2.2	3.6	10.6	2.1	-1.4	1.4	-0.5	-1.5	-3.2
Ever had stillbirth, spontaneous miscarriage or termination	4.1	4.4	6.0	-1.8	2.4	-2.4	2.3	2.5	0.6
Friendships satisfaction	2.1	2.6	4.0	1.4	-1.8	1.9	-1.7	-2.0	-0.3
Qualifications: nursing, teaching	0.6	1.0	1.5	1.0	0.8	-1.0	0.7	1.2	1.1
Commuting to job workplace: Walk	0.1	0.2	0.4	-0.6	0.3	-0.2	0.2	0.5	-0.3
Eye problems/disorders: Cataract	0.6	0.7	1.9	1.4	-0.2	0.2	-0.1	-0.4	1.4
Mouth/teeth dental problems: Mouth ulcers	2.4	3.9	7.2	-2.7	1.9	-2.1	2.1	1.9	0.0
Medication for cholesterol	0.3	0.4	0.7	-0.2	0.6	-0.8	0.8	0.8	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.5	-0.7	0.5	-0.3	0.2	0.1	-0.3
Back pain experienced in last month	0.3	0.5	1.6	-0.9	-0.3	-0.1	0.2	-0.4	-1.3
Mineral and other dietary supplements	0.7	0.9	1.7	1.3	-0.8	0.8	-0.8	-0.9	1.0
Breast cancer (self-reported)	0.8	1.0	2.5	1.6	-0.6	0.5	-0.6	-0.5	1.5
Asthma (self-reported)	0.2	0.3	1.5	1.2	0.1	-0.1	0.3	0.1	-0.6
Osteoporosis (self-reported)	0.3	0.3	0.9	-0.4	-0.4	0.1	0.7	-0.5	-0.9
Osteoarthritis (self-reported)	0.2	0.2	0.7	-0.8	0.4	-0.3	-0.4	0.3	-0.4
Medication: Aspirin	1.0	1.3	1.8	1.2	-1.2	1.0	-1.3	-1.3	0.5
Medication: Gliclazide	1.1	1.2	1.8	-0.7	1.4	-1.2	1.2	1.2	-0.8
Illnesses of father: None of the above (group 1)	0.5	0.6	2.9	0.7	0.1	-0.0	-0.2	-0.2	1.7
Smoking status: Current	0.1	0.2	0.4	0.5	-0.2	0.1	0.5	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	4.6	-2.1	1.1	-1.0	1.1	1.1	-0.6
Whole body water mass	3.0	17.0	23.7	-4.6	4.9	-4.6	3.7	4.7	0.4
Leg predicted mass (right)	2.0	10.8	15.4	-3.9	3.8	-3.5	3.0	3.6	-0.5
Arm fat mass (left)	0.2	1.0	4.2	-1.3	0.2	-0.1	0.0	0.1	-2.1
Number of self-reported non-cancer illnesses	0.5	0.9	1.7	-0.2	1.0	-1.3	1.2	1.2	-0.3
Average weekly champagne plus white wine intake	0.8	1.1	5.1	0.8	0.4	0.2	-0.6	0.4	2.2
Miserableness	0.7	1.3	3.0	1.0	-1.1	0.9	-0.5	-1.2	-1.7
Guilty feelings	4.3	6.5	8.8	-2.7	2.6	-2.9	2.8	3.0	0.2
Wears glasses or contact lenses	1.7	1.9	4.4	-1.0	1.3	-1.3	0.7	1.6	2.1
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.3	-0.0	-0.1	0.3	-0.2	0.5
Hearing aid user	0.4	0.4	1.2	1.1	0.4	-0.5	0.8	0.4	-0.2
Mother’s age at death	0.7	0.9	1.7	-0.5	0.6	-0.9	1.2	1.0	-1.3
Financial situation satisfaction	3.4	4.2	6.6	0.5	-2.2	2.2	-1.4	-2.5	-2.6
Tinnitus: Yes, now most or all of the time	2.0	2.3	6.2	2.5	-1.6	1.4	-1.2	-1.3	0.4
Commuting to job workplace: Public transport	0.2	0.3	0.5	-0.6	0.3	-0.6	0.5	0.7	0.3
Eye problems/disorders: Glaucoma	2.1	2.5	3.8	-1.1	1.8	-1.9	1.7	1.8	0.7
Medication: Blood pressure	0.1	0.1	0.2	0.3	-0.2	0.4	-0.3	-0.5	-0.3
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.1	1.1	0.2	-0.4	0.2	0.2	0.5
Supplements: Fish oil (including cod liver oil)	2.2	2.9	5.0	-2.2	1.8	-1.7	1.5	2.0	-0.6
High cholesterol (Self-reported)	1.5	2.6	3.6	1.0	-1.9	1.7	-1.7	-1.9	-1.4
Medication: Bendroflumethiazide	0.2	0.3	1.4	0.2	0.1	-0.3	0.4	0.0	1.2
Medication: Paracetamol	0.7	1.1	4.8	-0.8	-0.5	0.2	0.3	-0.7	-2.2
Medication: Lisinopril	1.3	1.7	3.5	-0.4	1.4	-1.5	1.9	1.4	-0.7
Medication: Atorvastatin	2.3	2.8	4.5	1.3	-1.9	1.7	-1.5	-2.1	-1.2
Illnesses of father: High blood pressure	2.2	2.8	3.8	-1.8	1.7	-1.8	2.0	1.9	-0.2
Alcohol drinker status: Never	0.1	0.2	0.6	0.8	-0.2	0.3	-0.1	0.0	0.4
Ever smoked	4.0	7.0	9.1	-2.7	3.0	-3.0	2.9	3.0	0.4
Basal metabolic rate	2.5	13.9	19.1	-4.3	4.4	-4.1	3.3	4.2	0.1
Leg fat percentage (left)	0.7	2.6	3.4	0.6	-1.8	1.8	-1.8	-1.8	-1.5
Arm fat-free mass (left)	2.5	12.9	19.0	-4.4	4.2	-4.0	3.0	4.0	0.0
Number of operations (self-reported)	1.0	1.5	2.7	0.1	1.3	-1.6	1.4	1.7	0.3
Average weekly beer plus cider intake	2.9	4.2	8.9	-3.0	2.1	-2.1	2.0	1.7	0.3
Irritability	0.2	0.3	1.0	-1.0	-0.1	-0.1	0.1	0.1	-1.0
Risk taking	4.1	5.9	9.4	-2.0	3.1	-2.7	2.6	2.6	1.0
Ever had prostate specific antigen (PSA) test	4.9	5.7	9.0	-1.0	2.7	-2.7	2.4	3.0	1.8
Fractured/broken bones in last 5 years	0.8	1.1	4.5	0.3	-0.6	0.4	0.4	-1.0	-2.1
Age started oral contraceptive pill	2.3	2.9	5.6	2.0	-1.7	1.9	-1.2	-2.4	-0.5
Diastolic blood pressure, automated reading	0.1	0.3	0.8	0.9	-0.2	0.3	-0.2	-0.2	-0.8
Ever depressed for a whole week	0.8	1.0	1.6	0.9	-1.2	1.1	-0.9	-1.3	-0.1
Unable to work because of sickness or disability	0.4	0.5	2.0	0.2	-0.7	0.6	-0.3	-0.5	-1.4
Commuting to job workplace: Cycle	0.1	0.1	0.4	-0.1	0.3	-0.5	-0.0	0.7	-0.1
Myopia	0.5	0.8	2.3	0.9	-0.7	0.7	-0.0	-0.8	-1.5
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.4	-0.2	-0.2	0.2	-0.6	0.2	0.1
Cholesterol lowering medication	1.7	2.5	4.0	1.3	-1.8	2.0	-1.2	-2.0	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.3	0.1	-0.7	0.7	-1.1	-0.6	-1.0
Pain experienced in last month	0.3	0.5	1.6	1.3	0.0	0.2	0.2	0.0	1.2
Supplements: Calcium	1.4	1.5	2.4	-0.3	1.3	-1.4	1.1	1.6	1.3
Basal cell carcinoma (self-reported)	1.6	1.9	3.1	-1.3	1.5	-1.6	1.2	1.8	-0.5
Heart attack/myocardial infarction (self-reported)	1.2	1.6	3.1	0.6	-1.2	1.2	-1.8	-1.6	0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.6	-1.3	-0.2	0.1	-0.1	-0.0	-1.2
Heart disease (siblings)	0.3	0.4	1.7	0.0	0.0	-0.3	0.6	-0.2	-1.3
Alcohol drinker status: Previous	0.1	0.1	0.6	0.3	0.0	0.1	-0.8	-0.1	-0.1
Pack years of smoking	1.6	2.3	3.7	0.5	-1.8	1.9	-1.1	-1.9	-1.5
Impedance of whole body	0.6	3.2	10.3	3.2	-1.5	1.2	-0.9	-1.0	1.9
Leg fat mass (left)	0.2	0.8	3.1	-1.2	0.2	-0.1	0.0	0.0	-1.8
Arm predicted mass (left)	2.3	11.9	18.9	-4.3	4.0	-3.8	2.8	3.8	0.1