TWAS hub - COQ10A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0537	0.0224	0.0012	0.019	NA	0.034	NA	0.026	0.00550	NA	0.00028	NA	0.00120
2	TCGA	Breast Invasive Carcinoma	0.0109	0.0069	0.0039	0.004	0.004	0.006	NA	0.005	0.03800	0.04100	0.02100	NA	0.02700
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0417	0.0259	0.0010	0.020	0.025	0.024	NA	0.026	0.00200	0.00067	0.00100	NA	0.00051
4	TCGA	Lung Adenocarcinoma	0.0553	0.0410	0.0046	0.018	0.015	0.005	NA	0.006	0.00320	0.00570	0.07000	NA	0.06300
5	TCGA	Prostate Adenocarcinoma	0.0284	0.0181	0.0024	0.030	0.019	0.013	NA	0.026	0.00038	0.00420	0.01500	NA	0.00091

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Forced vital capacity (FVC), Best measure	9.6	35.2	41.9	-5.2	-5.7	-5.9	-6.5	-6.3
Number of children fathered	9.6	10.8	15.8	-3.2	-2.7	-2.9	-3.5	-4.0
Forced expiratory volume in 1-second (FEV1), predicted	9.3	19.3	26.0	-4.0	-4.2	-4.4	-4.2	-5.1
Forced expiratory volume in 1-second (FEV1), Best measure	7.7	24.6	30.7	-4.5	-4.7	-4.9	-5.5	-5.1
Ever had stillbirth, spontaneous miscarriage or termination	6.5	7.0	9.4	-2.3	-2.7	-2.7	-3.1	-2.5
Medication: Allopurinol	6.4	8.5	9.6	-3.1	-3.1	-3.0	-2.7	-2.5
Ever had prostate specific antigen (PSA) test	6.3	7.2	7.8	-2.8	-2.8	-2.8	-2.3	-2.8
Past tobacco smoking	6.1	11.2	16.1	3.3	2.5	2.8	3.9	4.0
Forced vital capacity (FVC)	6.0	23.0	29.5	-3.9	-4.5	-4.8	-5.2	-5.4
Hair/balding pattern: Pattern 4	4.9	12.0	16.2	-2.8	-3.6	-3.7	-3.1	-4.0
Height	4.6	88.9	131.8	-7.0	-9.3	-9.9	-8.9	-11.5
Guilty feelings	4.6	6.9	9.1	-2.8	-2.1	-2.3	-3.0	-2.8
Chronotype (morning person)	4.3	10.0	12.0	-2.7	-3.2	-3.4	-3.5	-3.0
Standing height	4.3	43.0	63.5	-4.8	-6.4	-6.8	-6.3	-8.0
Smoking status: Previous	4.1	6.1	9.5	-2.4	-1.7	-1.9	-3.1	-3.0
Risk taking	4.1	5.9	7.9	-1.9	-2.4	-2.5	-2.5	-2.8
Forced expiratory volume in 1-second (FEV1)	4.0	13.6	18.0	-3.1	-3.5	-3.6	-4.2	-3.9
Glaucoma (self-reported)	4.0	4.7	6.9	-1.8	-2.0	-2.1	-2.3	-2.6
Illness, injury, bereavement, stress in last 2 years	4.0	4.9	7.2	-0.9	-2.2	-2.3	-2.7	-2.5
Illnesses of father: High blood pressure	4.0	4.9	7.1	-2.4	-2.7	-2.5	-1.6	-1.7
Friendships satisfaction	3.9	4.9	5.9	2.2	2.4	2.4	2.0	1.9
Medication: Atorvastatin	3.9	4.8	8.1	1.2	2.8	2.7	1.9	1.9
Ever smoked	3.9	6.9	9.9	-2.6	-2.2	-2.4	-2.6	-3.1
Age started oral contraceptive pill	3.8	4.7	6.1	2.1	2.2	2.2	2.5	1.9
Family relationship satisfaction	3.6	4.4	4.5	-2.1	-2.1	-2.1	-2.1	-2.1
Medication: Simvastatin	3.5	5.1	5.7	2.1	2.4	2.4	2.2	2.1
Stomach or abdominal pain in last month	3.2	4.0	5.4	1.4	2.3	2.3	1.9	1.9
Medication: Blood pressure	3.2	5.6	6.7	-2.6	-2.4	-2.4	-2.0	-2.3
Had major operations	3.2	3.8	4.2	-1.9	-2.0	-2.0	-1.8	-1.9
Trunk fat-free mass	3.1	17.8	30.6	-3.2	-3.4	-3.8	-4.7	-5.5
Trunk predicted mass	3.1	17.8	30.8	-3.2	-3.4	-3.8	-4.8	-5.5
Shortness of breath walking on level ground	3.1	3.7	4.7	2.2	1.8	1.8	2.0	1.8
Serious illness, injury or assault to yourself	3.0	3.7	7.7	0.4	1.5	1.8	2.2	2.8
Gout (self-reported)	2.9	3.9	4.9	-2.2	-1.9	-2.0	-1.8	-1.9
Medication: Seretide 50 evohaler	2.9	3.3	4.7	2.0	2.2	2.1	1.5	1.2
Townsend deprivation index at recruitment	2.8	3.9	5.4	-2.3	-1.7	-1.8	-2.1	-1.9
Heart attack	2.8	3.6	4.5	2.0	2.1	2.1	1.8	1.5
Falls in the last year	2.8	3.8	5.2	1.6	2.3	2.3	1.7	1.9
Pulse wave Arterial Stiffness index	2.8	3.3	4.8	-2.2	-1.4	-1.5	-2.2	-1.6
Illnesses of father: Heart disease	2.8	3.9	6.6	1.6	2.6	2.4	1.9	1.1
Supplements: Zinc	2.7	3.0	3.3	-1.6	-1.8	-1.8	-1.7	-1.7
Medication: Cholesterol lowering	2.7	4.3	6.8	1.8	2.0	2.0	2.6	1.8
Ever had bowel cancer screening	2.7	3.1	4.7	-1.8	-1.2	-1.4	-2.0	-2.2
Mouth/teeth dental problems: Mouth ulcers	2.7	4.3	7.6	-2.8	-1.8	-1.9	-1.7	-2.0
Blood Red Count	2.6	25.4	45.2	2.7	4.7	5.2	5.0	6.7
Had menopause	2.6	3.2	3.5	1.9	1.8	1.8	1.6	1.8
Hayfever/allergic rhinitis (self-reported)	2.5	3.3	4.4	-1.6	-2.1	-2.1	-1.5	-1.7
Whole body fat-free mass	2.5	14.1	22.8	-2.8	-3.0	-3.4	-4.4	-4.8
Qualifications: CSEs or equivalent	2.4	3.2	6.0	1.7	2.4	2.2	1.0	0.9
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.9	5.8	0.9	2.1	2.2	1.8	2.4
Medication: Ventolin 100micrograms inhaler	2.4	3.1	4.7	2.1	2.2	2.0	1.2	1.1
Commuting to job workplace: Car/motor vehicle	2.4	2.8	4.1	2.0	1.7	1.7	1.3	1.6
Tinnitus: Yes, now most or all of the time	2.4	2.8	3.7	1.9	1.6	1.6	1.9	1.4
Supplements: Fish oil (including cod liver oil)	2.4	3.2	4.1	-2.0	-1.8	-1.8	-1.4	-1.8
Lung FVC	2.3	11.6	14.8	-3.5	-3.0	-3.2	-3.9	-3.4
Whole body water mass	2.3	13.2	21.6	-2.6	-2.9	-3.2	-4.3	-4.6
Average weekly beer plus cider intake	2.3	3.3	5.5	-1.0	-1.6	-1.7	-2.4	-2.1
Average weekly spirits intake	2.2	2.7	4.4	1.2	1.4	1.5	2.1	1.7
Eye problems/disorders: Diabetes related eye disease	2.2	2.4	4.0	1.4	1.2	1.3	1.6	2.0
Sitting height	2.2	15.6	18.6	-3.1	-3.9	-4.0	-4.3	-4.3
Heart attack/myocardial infarction (self-reported)	2.2	2.8	3.7	1.8	1.9	1.9	1.4	1.3
Lung cancer (father)	2.1	2.5	3.4	1.8	1.6	1.7	1.1	1.6
Health satisfaction	2.1	2.7	4.0	1.1	1.5	1.6	2.0	1.9
Handedness (chirality/laterality): Left-handed	2.1	2.5	3.3	0.9	1.8	1.8	1.5	1.7
Cholesterol lowering medication	2.1	3.1	5.1	1.0	2.2	2.2	1.2	1.8
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	4.4	0.8	1.6	1.6	2.1	1.2
Arm fat-free mass (right)	2.0	10.5	18.3	-2.3	-2.4	-2.8	-4.0	-4.3
Basal metabolic rate	2.0	11.0	17.3	-2.5	-2.6	-2.9	-4.0	-4.2
Depressed Affect (Nagel 2018)	1.9	4.0	5.5	1.0	2.3	2.4	1.7	2.3
Reaction Time	1.9	3.5	5.8	-1.3	-1.9	-1.9	-2.4	-1.8
Overall health rating	1.9	4.1	5.8	0.2	2.3	2.4	1.9	2.4
Financial situation satisfaction	1.9	2.3	5.3	0.8	1.1	1.3	1.5	2.3
Medication: Lisinopril	1.9	2.5	3.1	-1.8	-1.6	-1.6	-1.5	-1.4
Primary Biliary Cirrhosis	1.8	2.6	5.1	1.0	1.9	0.0	1.8	2.2
Fed-up feelings	1.8	3.3	5.8	1.0	2.4	2.3	0.9	1.8
Medication: Ibuprofen	1.8	2.2	2.6	-1.5	-1.6	-1.6	-1.3	-1.4
Comparative height size at age 10	1.8	10.1	12.1	-2.6	-3.4	-3.5	-2.9	-3.5
Fasting Glucose	1.7	2.1	4.6	-2.2	-1.4	-0.9	-1.2	-1.2
Smoking Status	1.7	4.0	7.0	-2.7	-1.5	-1.6	-2.0	-2.1
Hypothyroidism (self reported)	1.7	4.0	6.3	2.5	2.0	1.9	2.1	1.2
Pulse wave peak to peak time	1.7	2.0	3.3	1.8	1.0	1.1	1.8	1.1
Leg fat-free mass (right)	1.7	9.0	14.4	-2.2	-2.5	-2.7	-3.8	-3.5
Leg predicted mass (right)	1.7	9.2	14.5	-2.2	-2.5	-2.8	-3.8	-3.6
High cholesterol (Self-reported)	1.7	3.1	4.7	1.1	2.2	2.1	1.4	1.7
Arm fat-free mass (left)	1.7	8.8	16.2	-2.1	-2.0	-2.4	-3.7	-4.0
Supplements: Calcium	1.7	1.8	2.6	-1.2	-1.3	-1.3	-1.6	-1.3
Angina	1.6	2.0	3.4	1.3	1.9	1.8	1.2	0.7
Pack years adult smoking proportion	1.6	2.5	4.7	0.8	1.4	1.6	1.6	2.2
Leg fat-free mass (left)	1.6	8.5	14.0	-2.1	-2.4	-2.6	-3.7	-3.4
Tinnitus: Yes, but not now, but have in the past	1.6	1.8	3.3	-1.3	-0.8	-0.9	-1.8	-1.5
Leg predicted mass (left)	1.6	8.5	14.0	-2.1	-2.4	-2.6	-3.7	-3.4
Arm predicted mass (left)	1.6	8.2	14.5	-2.1	-2.0	-2.4	-3.6	-3.8
Arm predicted mass (right)	1.5	7.8	13.5	-2.0	-1.9	-2.2	-3.6	-3.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	2.6	1.2	1.6	1.6	0.6	1.3
Eye problems/disorders: Glaucoma	1.5	1.7	3.7	-0.7	-1.0	-1.2	-1.4	-1.9
Angina (self-reported)	1.4	1.8	2.9	1.2	1.7	1.6	1.2	0.7
Chest pain or discomfort	1.4	2.0	2.7	1.0	1.6	1.6	1.1	1.4
Medication: Aspirin	1.4	1.9	5.1	0.6	1.1	1.2	2.2	1.1
Number of operations (self-reported)	1.4	2.1	3.1	-1.4	-1.3	-1.3	-1.8	-1.5
Supplements: Glucosamine	1.3	1.8	2.2	-1.5	-1.5	-1.4	-1.1	-1.2
Qualifications: None of the above	1.3	2.8	4.6	-1.9	-1.0	-1.2	-1.7	-2.1
Alcohol intake versus 10 years previously	1.3	1.9	3.6	-0.9	-1.0	-1.1	-1.9	-1.7
Migraine (self-reported)	1.3	1.6	2.0	-0.8	-1.4	-1.4	-1.2	-1.4
Mother’s age at death	1.3	1.7	2.9	-1.7	-1.3	-1.3	-1.3	-0.7
Ever depressed for a whole week	1.3	1.6	2.4	1.2	1.2	1.3	1.5	1.1
Basal cell carcinoma (self-reported)	1.3	1.5	2.7	-1.1	-0.9	-1.0	-1.3	-1.7
Hearing difficulty/problems with background noise	1.2	1.9	4.5	-2.1	-0.9	-1.0	-1.5	-1.0
Financial difficulties in last 2 years	1.2	1.6	2.4	0.6	1.2	1.4	1.5	1.4
Mouth/teeth dental problems: Dentures	1.2	2.1	2.9	1.3	1.7	1.7	1.3	1.2
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.1	-1.5	-1.3	-1.3	-1.1	-1.0
Number of self-reported non-cancer illnesses	1.2	2.0	3.7	-1.9	-1.3	-1.3	-1.3	-1.2
Pack years of smoking	1.2	1.8	3.4	0.6	1.2	1.4	1.4	1.9
Waist Hip Ratio (WHR)	1.1	5.0	7.9	-2.8	-2.2	-2.2	-1.9	-2.0
Medication: Levothyroxine sodium	1.1	1.9	2.7	1.1	1.5	1.4	1.6	1.2
Medication: Gliclazide	1.1	1.3	1.5	-1.2	-1.2	-1.2	-0.9	-1.2
Depression (Nagel 2018)	1.0	1.5	2.1	0.7	1.4	1.4	1.2	1.3
Schizophrenia (2018)	1.0	2.1	6.7	0.9	1.7	0.0	0.0	2.6
Coronary Artery Disease (CAD)	1.0	1.1	2.9	1.3	1.1	0.0	0.0	1.7
Chronic bronchitis/emphysema (mother)	1.0	1.1	3.5	0.2	-0.3	-0.6	-1.2	-1.9
Mean time to correctly identify matches	1.0	1.9	3.5	-0.4	-1.1	-1.2	-1.8	-1.9
Medication: Aspirin	1.0	1.3	3.7	0.4	1.0	1.0	1.9	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	3.4	-1.4	-1.5	-1.5	-1.9	-1.1
Wears glasses or contact lenses	1.0	1.2	1.6	-1.0	-1.0	-1.0	-1.1	-1.3
Body Mass Index (BMI) (2010)	0.9	1.2	2.9	1.2	1.7	0.0	0.6	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	2.6	1.0	1.6	1.5	0.5	1.1
Weight	0.9	4.6	8.4	-1.5	-1.6	-1.8	-2.9	-2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	1.8	-1.2	-1.2	-1.2	-1.0	-1.3
Pulse wave reflection index	0.9	1.1	2.1	-1.2	-0.5	-0.6	-1.4	-1.2
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	2.4	1.5	1.5	1.4	1.1	1.0
Medication: Amlodipine	0.9	1.3	2.2	-0.8	-1.1	-1.2	-1.0	-1.5
Leg fat percentage (right)	0.9	3.2	4.0	1.6	1.9	2.0	1.3	2.0
Pulse rate, automated reading	0.9	2.8	3.9	1.2	1.9	1.9	1.4	2.0
Suffer from ‘nerves’	0.9	1.4	2.7	-1.5	-0.7	-0.7	-1.6	-1.0
Average weekly red wine intake	0.9	1.3	2.7	0.9	1.0	1.1	1.0	1.7
Qualifications: nursing, teaching	0.9	1.3	2.0	-1.0	-1.2	-1.2	-1.4	-0.9
HbA1C	0.8	0.9	2.6	0.6	1.6	0.1	0.5	1.2
Ulcerative Colitis	0.8	1.2	2.6	-1.6	-1.3	0.0	0.0	-1.3
Pain all over the body in last month	0.8	0.9	1.2	0.9	0.9	1.0	1.1	0.7
Time employed in main current job	0.8	0.9	1.6	0.8	0.7	0.8	1.3	1.2
Alcohol intake frequency.	0.8	1.8	3.0	0.6	1.7	1.7	0.3	1.5
Crohns Disease (2017)	0.7	1.4	3.7	-1.9	-1.4	-1.1	-0.6	0.3
Ovarian Cancer	0.7	0.9	2.3	-0.1	-0.6	-0.7	-1.5	-1.1
Lupus	0.7	1.1	3.1	-0.7	-0.8	-1.2	-0.1	-1.8
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.6	0.2	1.2	1.2	1.1	1.6
Number of treatments/medications taken	0.7	1.3	2.6	-1.6	-1.0	-1.0	-1.0	-1.0
Relative age of first facial hair	0.7	1.5	3.0	1.4	0.9	0.9	1.7	1.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.1	-1.4	-0.9	-0.9	-0.7	-0.5
Diabetes (self-reported)	0.7	1.0	2.9	-0.0	0.8	0.9	0.9	1.7
Worrier / anxious feelings	0.7	1.3	2.3	0.2	1.2	1.3	1.1	1.5
Depression (self-reported)	0.7	0.8	2.2	0.5	0.7	0.9	0.7	1.5
Number of full sisters	0.7	0.8	1.5	-0.8	-1.2	-1.2	-0.2	-0.6
Knee pain experienced in last month	0.7	1.1	1.9	-1.4	-0.8	-0.9	-1.0	-1.0
Leg fat percentage (left)	0.7	2.7	3.5	1.4	1.8	1.9	1.2	1.8
Triglycerides	0.6	1.0	2.8	-1.7	-0.4	0.0	-0.9	-1.1
Blood White Count	0.6	4.3	6.6	1.4	2.6	2.5	1.7	1.9
Ever had hysterectomy (womb removed)	0.6	0.7	1.0	-0.6	-0.7	-0.8	-1.0	-1.0
Diabetes (mother)	0.6	0.7	1.4	1.2	0.9	0.8	0.5	0.6
Illnesses of siblings	0.6	0.8	1.7	1.3	0.6	0.6	0.7	1.0
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	1.7	1.3	1.0	1.0	0.7	1.1
Comparative body size at age 10	0.6	1.6	2.7	1.6	1.3	1.2	1.1	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.7	1.6	0.6	0.5	0.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.2	0.8	0.5	0.6	1.1	1.0
Loneliness, isolation	0.6	0.9	1.5	-0.5	1.2	1.2	-0.1	1.0
Mineral and other dietary supplements	0.6	0.7	0.8	0.8	0.9	0.9	0.8	0.9
Commuting to job workplace: Public transport	0.6	0.7	1.1	-0.9	-1.0	-1.0	-0.7	-0.4
Bipolar Disorder or Schizophrenia	0.5	1.3	3.9	0.3	1.5	0.0	0.0	2.0
Neuroticism (Nagel 2018)	0.5	1.1	1.9	-0.1	1.4	1.4	0.4	1.2
Neuroticism (2016)	0.5	0.7	1.3	0.2	0.9	1.2	0.4	1.1
Allergy or Eczema	0.5	1.2	2.1	-0.3	-1.4	-1.4	-0.1	-1.4
Medication: Metformin	0.5	0.7	1.3	-1.1	-1.0	-0.9	-0.3	-0.3
Maternal smoking around birth	0.5	0.7	1.4	-0.4	-0.8	-0.8	-1.2	-0.7
Age when periods started (menarche)	0.5	1.2	3.5	1.9	1.0	0.7	0.5	-0.7
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.2	-0.0	-1.2	-1.2	-0.1	-1.5
Number of incorrect matches in round	0.5	0.9	1.7	-1.0	-0.4	-0.6	-1.0	-1.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	0.9	0.7	0.9	0.9	0.7	0.7
Father’s age at death	0.5	0.6	1.1	-0.6	-1.0	-1.0	-0.1	-0.8
Happiness	0.5	0.6	1.0	1.0	1.0	0.9	0.3	0.5
Age at first live birth	0.5	1.0	1.6	1.3	0.8	0.8	1.0	0.9
Neck or shoulder pain in last month	0.5	0.8	1.8	0.1	1.3	1.2	0.8	-0.0
Hearing aid user	0.5	0.6	1.1	-1.1	-0.9	-0.9	-0.4	-0.4
Schizophrenia vs Biploar Disorder	0.4	0.5	1.9	-0.5	0.8	0.0	0.0	1.4
Worry (Nagel 2018)	0.4	0.7	1.2	-0.3	1.0	1.1	0.4	1.1
Mean Putamen Volume	0.4	0.4	1.0	0.7	1.0	0.0	0.0	0.8
HDL Cholesterol	0.4	0.7	1.5	0.0	-1.2	0.0	-1.0	-1.0
Heel T-Score	0.4	3.5	5.9	1.3	1.6	1.6	2.4	2.2
Cardiovascular Disease	0.4	1.4	3.3	-0.1	1.1	1.2	1.2	1.8
Tanning	0.4	4.9	10.8	-0.2	-1.7	-2.0	-2.6	-3.3
Sensitivity / hurt feelings	0.4	0.7	1.2	-0.6	1.1	1.0	-0.6	0.6
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	0.5	1.1	1.0	0.3	0.5
Pulse rate	0.4	0.7	1.5	0.7	0.6	0.7	0.8	1.2
Peak expiratory flow (PEF)	0.4	1.0	2.1	-0.2	-0.9	-0.9	-1.4	-1.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.7	0.2	0.0	0.2	1.3	1.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	0.8	-0.9	-0.8	-0.8	-0.7	-0.6
High blood pressure (siblings)	0.4	0.6	0.9	-1.0	-0.5	-0.6	-0.9	-0.9
Emphysema/chronic bronchitis	0.4	0.5	0.9	0.4	1.0	0.9	0.4	0.6
Illnesses of siblings: Diabetes	0.4	0.5	1.7	0.1	0.5	0.5	1.3	0.6
Arm fat percentage (left)	0.4	1.5	3.0	1.1	1.2	1.3	0.6	1.7
Mood swings	0.4	0.8	1.6	0.3	1.2	1.2	0.5	0.9
Diabetes diagnosed by doctor	0.4	0.7	2.1	-0.2	0.6	0.7	0.8	1.4
Commuting to job workplace: Walk	0.4	0.4	0.7	-0.8	-0.8	-0.8	-0.2	-0.3
Medication for cholesterol	0.4	0.5	1.0	0.1	-1.0	-1.0	-0.4	-0.8
Breast cancer (self-reported)	0.4	0.4	0.7	0.5	0.9	0.8	0.3	0.5
Fractured/broken bones in last 5 years	0.4	0.5	0.9	0.4	1.0	0.9	0.3	0.6
Alzheimer’s Disease (in father)	0.3	0.3	0.6	0.3	0.5	0.3	-0.7	-0.8
LDL Cholesterol	0.3	0.5	2.5	-1.6	-0.2	0.0	0.0	-0.4
Blood Platelet Count	0.3	3.8	9.4	-1.5	-1.6	-1.8	-1.2	-3.1
Vitamin and mineral supplements	0.3	0.4	0.7	0.3	0.7	0.7	0.3	0.8
Relative age voice broke	0.3	0.4	1.0	0.5	0.4	0.4	1.0	0.7
Taking other prescription medications	0.3	0.4	0.8	-0.8	-0.3	-0.4	-0.9	-0.7
Chronic bronchitis/emphysema (father)	0.3	0.4	0.9	0.2	0.4	0.5	1.0	0.8
Had other major operations	0.3	0.3	0.8	0.2	-0.0	-0.2	-0.9	-0.9
Prospective memory result	0.3	0.3	0.5	-0.5	-0.7	-0.7	-0.1	-0.6
Exposure to tobacco smoke at home	0.3	0.3	1.3	1.1	0.1	0.0	0.3	-0.5
Birth weight of first child	0.3	0.6	1.6	-0.3	-1.2	-1.1	0.2	-0.3
Loud music exposure frequency	0.3	0.3	0.5	-0.2	0.6	0.6	0.5	0.7
Medication: Paracetamol	0.3	0.5	1.3	-1.2	-0.5	-0.4	-0.8	0.2
Birth weight	0.3	0.6	1.0	0.8	-0.6	-0.7	0.7	-1.0
Body fat percentage	0.3	1.2	2.3	1.0	1.0	1.1	0.6	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.8	0.3	0.2	-1.1	-0.2
Medication: Omeprazole	0.3	0.4	1.2	0.1	0.6	0.6	-1.1	0.2
Heart disease (mother)	0.3	0.3	1.0	-0.3	-0.3	-0.4	-1.0	-0.6
Leg pain on walking	0.3	0.4	0.7	0.7	0.8	0.6	0.6	-0.2
Hypertension (Self-reported)	0.3	0.9	2.8	-1.7	-0.6	-0.6	-0.8	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	-0.4	-0.7	-0.7	-0.9	-0.4
Osteoarthritis (self-reported)	0.3	0.4	0.7	0.8	0.8	0.6	-0.3	-0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.9	0.3	0.9	0.7	-0.1	-0.3
Commuting to job workplace: Cycle	0.3	0.4	0.8	-0.6	-0.9	-0.8	0.2	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.5	0.3	0.6	0.6	-0.5	0.7
Heart disease (siblings)	0.3	0.4	1.6	-1.3	-0.3	-0.2	-0.5	-0.1
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.4	-0.5	-1.2	-1.1	0.2	-0.2
Major Depression (MDD)	0.2	0.2	0.4	-0.7	0.4	0.3	0.0	0.7
Age at First Birth	0.2	0.2	0.8	0.9	-0.2	0.0	0.4	-0.4
Schizophrenia (2014)	0.2	0.5	2.5	-0.1	0.4	0.0	0.0	1.6
Systolic Blood Pressure	0.2	0.8	3.1	-1.8	-0.7	-0.6	0.1	0.0
Respiratory disease	0.2	0.4	0.6	0.3	-0.8	-0.7	-0.3	-0.7
Neuroticism	0.2	0.4	0.9	-0.9	0.7	0.7	-0.2	0.5
Hand grip strength (left)	0.2	0.5	1.1	0.1	-0.7	-0.8	-0.3	-1.1
Medication: Co-codamol	0.2	0.2	0.6	-0.1	-0.3	-0.4	-0.6	-0.8
Diabetes (father)	0.2	0.2	0.4	0.0	-0.6	-0.6	0.1	-0.6
Hand grip strength (right)	0.2	0.5	0.9	0.1	-1.0	-1.0	-0.1	-0.8
Current tobacco smoking	0.2	0.3	1.0	-0.4	0.1	0.2	1.0	0.6
Average weekly fortified wine intake	0.2	0.2	1.0	1.0	0.1	0.0	0.1	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.1	-0.4	0.2	0.3	0.8	1.0
High blood pressure	0.2	0.6	2.1	-1.4	-0.3	-0.4	-0.7	-0.4
High blood pressure (mother)	0.2	0.3	0.6	-0.2	-0.7	-0.8	-0.5	-0.2
Body mass index (BMI)	0.2	0.8	1.4	0.5	1.2	1.1	-0.2	0.9
Waist circumference	0.2	0.8	1.5	-1.0	-0.4	-0.5	-1.2	-0.9
Alcohol usually taken with meals	0.2	0.4	0.7	-0.4	-0.8	-0.8	-0.7	-0.1
Nervous feelings	0.2	0.4	0.9	-0.6	0.5	0.5	-0.2	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.5	-0.5	0.1	0.3	1.0	1.2
Fluid intelligence score	0.2	0.3	0.5	0.6	0.5	0.5	0.7	0.6
Neuroticism score	0.2	0.5	0.7	-0.9	0.6	0.6	-0.4	0.7
Impedance of arm (right)	0.2	0.7	1.4	-0.1	-1.2	-0.9	0.9	0.8
Arm fat percentage (right)	0.2	0.7	1.7	0.6	0.7	0.8	0.3	1.3
Number of live births	0.2	0.2	0.4	0.0	-0.4	-0.5	-0.6	-0.6
Noisy workplace	0.2	0.2	0.4	0.1	-0.7	-0.6	0.3	-0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.8	-0.6	-0.9	-0.6	0.3	0.7
Asthma	0.2	0.3	1.2	1.1	0.2	0.2	0.6	0.2
Medication: Lansoprazole	0.2	0.2	0.7	-0.1	0.3	0.4	0.3	0.8
Illnesses of mother	0.2	0.2	0.4	0.4	0.6	0.6	0.4	-0.1
Length of working week for main job	0.2	0.2	0.6	-0.5	-0.2	-0.1	0.8	0.1
Breastfed as a baby	0.2	0.2	0.4	-0.4	-0.6	-0.6	-0.3	-0.2
Tense / ‘highly strung’	0.2	0.3	0.4	-0.6	0.5	0.5	-0.7	0.6
Blood clot in the leg (DVT)	0.2	0.2	0.8	-0.2	0.4	0.3	-0.9	0.1
Exposure to tobacco smoke outside home	0.2	0.3	0.9	0.2	0.9	0.8	0.3	-0.0
Qualifications: College or University degree	0.2	0.5	1.0	-0.5	-1.0	-0.9	-0.7	-0.3
Eye problems/disorders: None of the above	0.2	0.2	0.5	-0.7	-0.6	-0.5	-0.3	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	0.2	-0.4	-0.4	-0.3	-0.7
Long-standing illness, disability or infirmity	0.2	0.3	0.6	-0.7	0.2	0.3	0.4	0.8
Eye problems/disorders: Cataract	0.2	0.3	0.4	0.5	0.6	0.6	0.5	0.4
Illnesses of father: None of the above (group 1)	0.2	0.3	0.8	0.7	-0.2	-0.1	-0.9	-0.0
Smoking status: Current	0.2	0.3	1.2	-1.1	-0.5	-0.4	0.3	0.0
Average weekly champagne plus white wine intake	0.2	0.3	0.6	0.7	-0.8	-0.7	0.1	-0.1
Miserableness	0.2	0.3	1.2	0.2	0.2	0.3	0.2	1.1
Medication: Blood pressure	0.2	0.4	0.9	0.3	1.0	0.9	0.2	0.3
Medication: Paracetamol	0.2	0.2	1.0	-1.0	0.0	0.1	0.0	0.4
Myopia	0.2	0.3	0.6	-0.8	-0.1	0.1	0.4	0.7
Pain experienced in last month	0.2	0.3	0.7	0.2	-0.9	-0.7	-0.2	0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.9	-0.0	0.3	0.3	-0.9	0.2
Impedance of whole body	0.2	0.8	2.0	0.3	-0.5	-0.2	1.4	1.3
Bipolar Disorder (2018)	0.1	0.1	0.5	-0.7	0.3	0.0	0.0	-0.1
Alzheimer’s Disease (in mother)	0.1	0.2	0.7	-0.2	-0.1	0.0	-0.1	0.8
Alzheimer’s Disease (including proxy)	0.1	0.2	0.8	-0.3	-0.2	-0.3	-0.9	-0.2
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	-0.8	-0.5	-0.4	-0.1	0.4
Crohns Disease (2012)	0.1	0.1	0.2	-0.5	0.4	0.0	0.0	0.4
Rheumatoid Arthritis	0.1	0.1	0.5	-0.7	-0.4	0.0	-0.1	-0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	-0.7	0.4	0.0	0.0	-0.3
Blood Eosinophil Count	0.1	1.0	2.8	1.7	0.5	0.4	1.3	-0.3
BMI	0.1	0.5	0.9	0.3	0.8	0.8	-0.5	1.0
Lung FEV1/FVC ratio	0.1	0.4	1.9	-0.5	0.1	0.1	-1.4	0.2
Hearing difficulty/problems: Yes	0.1	0.1	0.1	-0.1	0.4	0.3	-0.2	0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.3	0.2	0.1	-0.0	-0.5
Systolic blood pressure, automated reading	0.1	0.3	1.6	-1.2	0.1	0.1	-0.2	-0.1
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.1	-0.6	-0.5	0.3	-0.3
Severe depression (siblings)	0.1	0.1	0.2	-0.4	-0.1	-0.1	0.1	-0.4
Impedance of leg (right)	0.1	0.7	2.5	0.4	-0.0	0.1	1.6	0.9
Trunk fat percentage	0.1	0.4	1.0	0.7	0.4	0.5	0.1	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.6	-0.8	-0.4	-0.3	0.1	0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.6	0.1	0.3	0.2	-0.7	-0.2
Multivitamins +/- minerals	0.1	0.1	0.2	0.5	-0.3	-0.3	0.1	-0.3
Medication: Atenolol	0.1	0.1	0.3	-0.1	0.5	0.4	0.1	-0.4
Impedance of leg (left)	0.1	0.7	2.6	0.3	-0.1	0.1	1.6	0.9
Trunk fat mass	0.1	0.4	1.2	-0.2	-0.5	-0.5	-1.1	-0.5
Mouth/teeth dental problems	0.1	0.1	0.2	0.4	-0.5	-0.4	-0.2	0.2
Allergy	0.1	0.2	0.7	-0.8	0.3	0.3	-0.3	0.4
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	-0.0	0.5	0.4	0.1	-0.2
Impedance of arm (left)	0.1	0.7	1.2	0.2	-0.8	-0.5	1.1	1.1
Arm fat mass (right)	0.1	0.3	1.2	-0.4	-0.1	-0.2	-1.1	-0.3
Number of full brothers	0.1	0.1	0.1	0.3	0.3	0.3	0.3	0.4
Worry too long after embarrassment	0.1	0.2	0.8	-0.2	0.2	0.3	0.1	0.9
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.3	0.3	0.4	0.4	0.3	0.5
Medication for pain relief, constipation, heartburn	0.1	0.2	0.7	0.4	-0.2	-0.4	-0.2	-0.8
Whole body fat mass	0.1	0.4	1.2	-0.3	-0.3	-0.4	-1.1	-0.5
Age at last live birth	0.1	0.1	0.3	0.4	-0.2	-0.1	0.2	0.6
Supplements: Vitamin C	0.1	0.1	0.2	-0.5	-0.2	-0.1	0.3	0.1
Back pain experienced in last month	0.1	0.2	0.3	-0.3	0.6	0.5	0.6	0.1
Asthma (self-reported)	0.1	0.2	0.7	0.8	-0.3	-0.3	0.4	-0.1
Osteoporosis (self-reported)	0.1	0.1	0.5	-0.7	-0.0	0.0	-0.1	0.3
Ever taken oral contraceptive pill	0.1	0.1	0.4	0.2	-0.6	-0.5	0.2	0.1
Medication: Bendroflumethiazide	0.1	0.1	0.5	0.7	-0.1	-0.1	0.1	-0.3
Alcohol drinker status: Never	0.1	0.1	0.2	-0.4	-0.3	-0.3	-0.5	0.2
Diastolic blood pressure, automated reading	0.1	0.2	0.4	-0.5	0.6	0.6	-0.3	0.3
Unable to work because of sickness or disability	0.1	0.1	0.3	-0.3	0.2	0.3	0.2	0.6
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.9	0.9	-0.3	-0.3	0.4	0.1
Ulcerative Colitis (UC)	0.0	0.0	0.0	-0.1	-0.0	-0.1	-0.2	-0.0
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.1	-0.0	-0.4	-0.3	0.3	0.4
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.2	5.5	-2.3	-0.4	-0.3	-0.1	0.0
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	-0.1	0.0	0.0	0.1	-0.3
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	-0.3	-0.1	-0.1	0.2	0.1
Medication: Ramipril	0.0	0.1	0.1	0.0	-0.3	-0.2	0.1	0.3
Hip circumference	0.0	0.2	0.7	0.1	0.1	-0.0	-0.8	-0.4
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.2	-0.3
Headache pain in last month	0.0	0.1	0.1	-0.2	0.4	0.3	-0.2	0.1
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	-0.2	0.1	0.1	-0.1	-0.0
Leg fat mass (right)	0.0	0.1	0.3	0.3	0.4	0.4	-0.6	0.0
Arm fat mass (left)	0.0	0.2	0.9	-0.1	0.1	0.1	-0.9	-0.1
Irritability	0.0	0.1	0.1	0.4	0.3	0.2	-0.2	-0.0
Alcohol drinker status: Previous	0.0	0.0	0.1	0.2	0.0	0.1	-0.3	0.1
Leg fat mass (left)	0.0	0.1	0.5	0.1	0.3	0.3	-0.7	-0.1

Hub : Genes

COQ10A

Models

Trait associations