Best TWAS P=1.53e-12 · Best GWAS P=8.47e-20 conditioned to 4.02e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | SCAND2P | 0.12 | 0.05 | enet | 16 | 0.08 | 8.7e-07 | -4.249 | -5.3 | 1.0e-07 | 0.39 | 0.22 | 0.66 | FALSE |
2 | GTEx | Artery Tibial | AC103965.1 | 0.27 | 0.26 | enet | 31 | 0.30 | 1.8e-23 | 4.467 | -7.1 | 1.5e-12 | 0.56 | 1.00 | 0.00 | TRUE |
3 | GTEx | Artery Tibial | CSPG4P11 | 0.16 | 0.24 | lasso | 4 | 0.23 | 3.0e-18 | 4.467 | -5.6 | 1.9e-08 | 0.54 | 1.00 | 0.00 | FALSE |
4 | GTEx | Brain Cerebellar Hemisphere | UBE2Q2P1 | 0.18 | 0.08 | enet | 18 | 0.12 | 4.2e-04 | 4.581 | 5.3 | 1.5e-07 | -0.45 | 0.18 | 0.18 | FALSE |
5 | GTEx | Brain Cerebellum | AC103965.1 | 0.13 | 0.02 | enet | 21 | 0.01 | 2.1e-01 | 4.628 | -6.3 | 3.3e-10 | 0.67 | 0.04 | 0.71 | FALSE |
6 | GTEx | Brain Cortex | RP11-182J1.14 | 0.24 | 0.03 | enet | 14 | 0.16 | 3.2e-05 | 4.863 | 6.3 | 3.0e-10 | -0.46 | 0.07 | 0.22 | FALSE |
7 | GTEx | Breast Mammary Tissue (Male) | AC103965.1 | 0.24 | 0.14 | lasso | 4 | 0.11 | 1.4e-03 | 4.509 | -5.7 | 1.6e-08 | 0.53 | 0.12 | 0.28 | FALSE |
8 | GTEx | Breast Mammary Tissue (Male) | CSPG4P11 | 0.05 | 0.02 | lasso | 6 | 0.03 | 7.1e-02 | 4.910 | -5.2 | 1.6e-07 | 0.44 | 0.03 | 0.09 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | SCAND2P | 0.29 | 0.20 | enet | 39 | 0.21 | 6.5e-16 | -4.249 | -6.0 | 2.6e-09 | 0.32 | 0.36 | 0.60 | FALSE |
10 | GTEx | Colon Sigmoid | RN7SL417P | 0.17 | 0.06 | lasso | 4 | 0.12 | 6.1e-05 | 4.831 | 5.2 | 2.0e-07 | -0.46 | 0.28 | 0.09 | FALSE |
11 | GTEx | Colon Transverse | RP11-182J1.14 | 0.23 | 0.19 | enet | 27 | 0.18 | 3.9e-09 | 4.628 | 5.6 | 2.1e-08 | -0.46 | 1.00 | 0.00 | FALSE |
12 | GTEx | Esophagus Gastroesophageal Junction | SCAND2P | 0.21 | 0.11 | lasso | 3 | 0.12 | 3.4e-05 | -4.249 | -5.2 | 1.6e-07 | 0.39 | 0.14 | 0.35 | FALSE |
13 | GTEx | Esophagus Gastroesophageal Junction | RP11-382A20.2 | 0.13 | 0.03 | enet | 20 | 0.07 | 1.1e-03 | 3.074 | 5.6 | 2.2e-08 | -0.12 | 0.11 | 0.14 | FALSE |
14 | GTEx | Esophagus Mucosa | AC103965.1 | 0.20 | 0.19 | enet | 47 | 0.16 | 8.4e-11 | 4.467 | -5.2 | 1.5e-07 | 0.38 | 1.00 | 0.00 | FALSE |
15 | GTEx | Nerve Tibial | AC103965.1 | 0.20 | 0.22 | enet | 17 | 0.27 | 5.1e-19 | 4.467 | -6.1 | 1.2e-09 | 0.58 | 1.00 | 0.00 | FALSE |
16 | GTEx | Pituitary | AC103965.1 | 0.30 | 0.16 | enet | 10 | 0.24 | 8.4e-07 | 4.247 | -5.2 | 2.4e-07 | 0.45 | 0.40 | 0.22 | FALSE |
17 | GTEx | Prostate | RP11-182J1.16 | 0.24 | 0.06 | enet | 27 | 0.08 | 6.2e-03 | 0.093 | -5.6 | 1.7e-08 | 0.48 | 0.09 | 0.10 | FALSE |
18 | GTEx | Prostate | RP11-182J1.14 | 0.25 | 0.09 | enet | 25 | 0.09 | 2.9e-03 | 4.793 | 5.7 | 1.5e-08 | -0.35 | 0.19 | 0.07 | FALSE |
19 | GTEx | Small Intestine Terminal Ileum | RP11-182J1.14 | 0.26 | 0.01 | enet | 27 | 0.12 | 1.3e-03 | -9.050 | 6.8 | 1.4e-11 | -0.61 | 0.02 | 0.63 | TRUE |
20 | The Cancer Genome Atlas | Esophageal Carcinoma | GOLGA6L5 | 0.12 | 0.07 | blup | 7 | 0.12 | 1.0e-04 | -4.929 | -5.2 | 2.1e-07 | 0.35 | 0.00 | 0.73 | FALSE |
21 | The Cancer Genome Atlas | Glioblastoma Multiforme | GOLGA6L5 | 0.20 | 0.05 | blup | 7 | 0.07 | 4.7e-03 | -4.929 | -5.3 | 1.2e-07 | 0.35 | 0.00 | 0.43 | FALSE |
22 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZSCAN2 | 0.11 | 0.00 | blup | 46 | 0.03 | 1.2e-04 | 2.966 | 5.8 | 5.4e-09 | -0.25 | 0.01 | 0.38 | FALSE |
23 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GOLGA6L5 | 0.04 | 0.01 | blup | 7 | 0.03 | 4.9e-04 | 4.685 | -5.7 | 1.6e-08 | 0.44 | 0.00 | 0.75 | FALSE |
24 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | GOLGA6L5 | 0.06 | 0.06 | blup | 7 | 0.06 | 1.5e-04 | -4.929 | -5.2 | 2.4e-07 | 0.40 | 0.00 | 0.88 | FALSE |
25 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GOLGA6L5 | 0.06 | 0.09 | blup | 7 | 0.09 | 1.5e-10 | -3.934 | -5.5 | 4.8e-08 | 0.40 | 0.01 | 0.94 | FALSE |
26 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | WHAMM | 0.14 | 0.05 | enet | 11 | 0.08 | 1.0e-04 | -4.681 | 5.7 | 1.4e-08 | -0.15 | 0.01 | 0.98 | TRUE |
27 | The Cancer Genome Atlas | Stomach Adenocarcinoma | GOLGA6L5 | 0.07 | 0.01 | enet | 5 | 0.06 | 5.2e-05 | -3.934 | -5.3 | 1.4e-07 | 0.40 | 0.01 | 0.78 | FALSE |