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chr20:31,382,860-34,697,305

Best TWAS P=1.56e-11 · Best GWAS P=5.42e-11 conditioned to 0.428

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
21	The Cancer Genome Atlas	Stomach Adenocarcinoma	GDF5	0.09	0.04	enet	13	0.05	2.4e-04	6.6	6.7	1.6e-11	0.85	0.00	0.99	TRUE
6	GTEx	Brain Putamen basal ganglia	E2F1	0.18	0.22	lasso	6	0.21	1.2e-05	-6.3	6.2	6.0e-10	0.01	0.03	0.94	TRUE
2	GTEx	Artery Tibial	TP53INP2	0.09	0.08	lasso	1	0.07	5.6e-06	5.8	5.8	6.1e-09	0.06	0.01	0.98	TRUE
3	GTEx	Artery Tibial	GSS	0.06	0.02	enet	25	0.04	7.7e-04	5.8	6.2	6.6e-10	0.35	0.20	0.39	FALSE
13	The Cancer Genome Atlas	Colon Adenocarcinoma	CBFA2T2	0.13	0.04	lasso	1	0.03	1.1e-02	-6.2	6.2	7.1e-10	0.01	0.01	0.69	FALSE
8	GTEx	Testis	CBFA2T2	0.10	0.07	enet	11	0.07	6.1e-04	-6.0	6.1	1.1e-09	-0.02	0.06	0.88	FALSE
1	CommonMind	Brain Pre-frontal Cortex	E2F1	0.06	0.01	bslmm	268	0.02	1.6e-03	-6.0	6.0	2.1e-09	0.06	0.04	0.74	FALSE
19	The Cancer Genome Atlas	Prostate Adenocarcinoma	GDF5	0.05	0.05	lasso	5	0.04	7.2e-05	6.6	6.0	2.6e-09	0.95	0.00	1.00	FALSE
4	GTEx	Brain Hippocampus	E2F1	0.39	0.25	lasso	8	0.18	4.1e-05	-6.3	5.9	4.5e-09	-0.01	0.02	0.95	FALSE
5	GTEx	Brain Hypothalamus	E2F1	0.26	0.02	lasso	5	0.12	9.1e-04	2.7	5.7	1.3e-08	0.06	0.04	0.57	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	GGT7	0.02	0.02	lasso	3	0.02	2.2e-04	5.8	-5.5	3.5e-08	-0.09	0.01	0.90	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	UQCC	0.15	0.21	blup	67	0.22	1.2e-20	5.3	-5.5	4.6e-08	-0.88	0.46	0.54	FALSE
11	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	UQCC	0.03	0.04	blup	67	0.03	2.6e-03	5.0	-5.4	5.2e-08	-0.91	0.02	0.91	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	UQCC1	0.05	0.05	lasso	5	0.06	1.7e-08	5.2	-5.4	5.8e-08	-0.84	0.22	0.78	FALSE
9	NTR	Blood	UQCC	0.01	0.01	enet	6	0.00	1.6e-02	5.0	-5.4	6.0e-08	-0.89	0.09	0.77	FALSE
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	CBFA2T2	0.02	0.01	blup	31	0.01	1.8e-02	-6.1	5.3	9.6e-08	0.02	0.01	0.70	FALSE
18	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	UQCC	0.22	0.21	lasso	7	0.18	1.9e-07	4.9	-5.3	1.1e-07	-0.84	0.30	0.70	FALSE
7	GTEx	Breast Mammary Tissue (Male)	UQCC1	0.06	0.04	lasso	1	0.02	1.4e-01	5.3	-5.3	1.2e-07	-0.90	0.04	0.12	FALSE
20	The Cancer Genome Atlas	Soft Tissue Sarcoma	UQCC	0.07	0.06	blup	66	0.07	5.2e-05	5.0	-5.3	1.2e-07	-0.89	0.02	0.97	FALSE
22	The Cancer Genome Atlas	Thyroid Carcinoma	CEP250	0.05	0.03	blup	43	0.04	5.8e-05	4.3	5.3	1.2e-07	0.78	0.12	0.83	FALSE
17	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GDF5	0.05	0.02	blup	76	0.04	1.4e-03	5.0	5.2	2.4e-07	0.89	0.03	0.91	FALSE
14	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CEP250	0.02	0.01	blup	43	0.02	8.0e-04	4.3	5.1	3.1e-07	0.79	0.03	0.83	FALSE
16	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UQCC	0.07	0.08	blup	67	0.07	1.1e-08	5.0	-5.1	3.1e-07	-0.82	0.05	0.95	FALSE