Hub : Genes

E2F1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.062 0.0320 1.2e-03 0.008 0.017 0.013 0.02 0.019 3.0e-02 0.0028 7.9e-03 0.0016 2.0e-03
2 GTEx Artery Tibial 0.270 0.0985 2.6e-03 -0.003 NA -0.002 NA -0.002 6.0e-01 NA 4.9e-01 NA 5.5e-01
3 GTEx Brain Cortex 0.217 0.0920 8.9e-04 0.142 NA 0.100 NA 0.133 1.0e-04 NA 1.0e-03 NA 1.7e-04
4 GTEx Brain Hippocampus 0.391 0.1074 6.8e-06 0.253 NA 0.182 NA 0.185 1.2e-06 NA 4.7e-05 NA 4.1e-05
5 GTEx Brain Hypothalamus 0.261 0.1100 2.2e-03 0.020 NA 0.013 NA 0.121 1.1e-01 NA 1.6e-01 NA 9.1e-04
6 GTEx Brain Putamen basal ganglia 0.180 0.0690 5.0e-04 0.215 NA 0.163 NA 0.206 7.7e-06 NA 1.1e-04 NA 1.2e-05
7 GTEx Esophagus Mucosa 0.071 0.0360 2.4e-03 0.037 NA 0.027 NA 0.027 1.6e-03 NA 5.8e-03 NA 5.9e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.2 0.3 1.5 -0.3 0.0 -1.2 -0.0 -0.4 0.2 0.6
Bipolar Disorder or Schizophrenia 0.1 0.3 0.9 0.9 0.0 0.3 0.6 -0.1 0.9 -0.2
Depressed Affect (Nagel 2018) 1.1 2.2 9.5 0.1 0.0 -1.5 -1.4 -3.1 -0.9 1.1
Depression (Nagel 2018) 3.6 5.4 16.0 -1.5 0.0 -2.0 -2.5 -4.0 -2.3 1.9
Intelligence (Savage-Jansen 2018) 0.5 1.4 6.7 2.6 0.0 -1.3 -0.3 -0.2 0.5 -1.2
Neuroticism (Nagel 2018) 1.3 3.0 8.5 -0.6 0.0 -2.0 -2.0 -2.9 -1.5 1.3
Schizophrenia (2018) 0.4 0.8 1.8 1.3 0.0 1.3 0.8 0.2 1.0 -0.7
Schizophrenia vs Biploar Disorder 0.2 0.3 1.3 1.1 0.0 0.2 -0.0 0.3 0.3 0.8
Worry (Nagel 2018) 0.6 1.2 3.0 -1.1 0.0 -1.0 -1.2 -1.7 -1.1 0.9
Alzheimer’s Disease (in mother) 1.9 2.3 5.1 -1.2 0.0 -1.9 -2.2 -0.7 -2.0 0.9
Alzheimer’s Disease (in father) 0.2 0.2 0.5 -0.7 0.0 0.1 -0.1 -0.7 -0.3 -0.2
Alzheimer’s Disease (including proxy) 1.3 1.9 3.4 -1.2 0.0 -1.8 -1.9 -0.8 -1.8 1.0
Crohns Disease (2017) 0.8 1.7 3.7 1.1 0.0 1.6 1.4 1.1 1.2 -1.9
Irritable Bowel Disease (IBD) 0.5 1.3 2.6 1.6 0.0 0.9 0.9 1.2 1.0 -1.6
Ulcerative Colitis (UC) 0.1 0.2 0.7 0.9 0.0 -0.3 -0.1 0.7 0.1 -0.5
Major Depression (MDD) 0.3 0.4 1.4 0.5 0.0 -0.8 -0.5 -1.2 -0.2 -0.2
Reaction Time 0.3 0.6 1.5 -1.1 0.0 0.7 0.7 1.2 0.6 -0.2
Verbal and Numeric Reasoning (VNR) 0.2 0.6 1.8 1.0 0.0 -1.4 -0.4 -0.8 -0.0 -0.5
Breast Cancer 0.4 1.0 3.9 1.2 0.0 -2.0 -0.8 -0.9 0.1 0.1
Ovarian Cancer 0.4 0.5 0.9 -0.9 0.0 0.9 -0.4 0.7 -0.3 1.0
Prostate Cancer 0.1 0.2 0.8 0.9 0.0 -0.5 0.2 0.1 0.4 0.5
Age at First Birth 0.6 0.8 1.8 -1.0 0.0 -0.6 -1.3 0.7 -1.1 1.0
Bipolar Disorder (2011) 0.1 0.1 0.4 0.2 0.0 -0.4 -0.4 -0.6 -0.5 0.1
Body Mass Index (BMI) (2010) 0.5 0.7 2.2 1.5 0.0 0.6 1.0 -0.3 0.8 -0.7
Coronary Artery Disease (CAD) 0.5 0.6 1.5 -1.1 0.0 -1.2 -0.5 -1.0 -0.5 -0.5
Crohns Disease (2012) 0.4 0.6 1.7 -0.4 0.0 0.9 0.9 0.8 0.5 -1.3
Mean Putamen Volume 1.2 1.3 5.0 2.2 0.0 0.8 0.9 1.0 0.9 -1.0
Fasting Glucose 2.6 3.1 7.9 -0.4 0.0 -1.5 -2.8 0.1 -2.8 1.8
HbA1C 1.4 1.5 4.4 2.1 0.0 0.7 1.4 -0.3 1.8 -0.9
HDL Cholesterol 0.4 0.7 3.5 0.1 0.0 -1.9 -0.6 -0.4 -0.3 0.9
LDL Cholesterol 0.1 0.2 0.7 -0.2 0.0 0.3 0.4 0.4 0.3 0.8
Lupus 1.8 2.8 5.2 2.0 0.0 1.4 1.9 2.3 2.1 -0.7
Neuroticism (2016) 0.3 0.5 2.7 -0.3 0.0 -0.6 -0.0 -1.6 -0.1 -0.3
Primary Biliary Cirrhosis 3.2 4.5 8.8 3.0 0.0 1.1 2.6 1.6 2.9 -2.0
Rheumatoid Arthritis 0.2 0.3 0.9 0.0 0.0 -1.0 -0.7 0.4 -0.7 0.0
Schizophrenia (2014) 0.6 1.2 3.8 1.9 0.0 1.1 0.9 0.7 1.4 -0.5
Triglycerides 0.2 0.3 0.9 0.4 0.0 0.5 -0.4 -0.2 -0.7 1.0
Type 2 Diabetes (T2D) (2012) 2.1 2.4 5.3 -1.5 0.0 -2.2 -1.6 -0.6 -1.4 2.3
Ulcerative Colitis 0.5 0.7 2.5 0.8 0.0 0.6 0.3 1.6 0.6 -1.0
Blood Eosinophil Count 0.1 0.5 2.1 -0.7 0.0 -0.4 0.6 -1.5 0.5 0.5
Blood Platelet Count 2.1 24.1 37.3 -6.0 0.0 -3.8 -6.0 -3.9 -6.1 5.5
Blood Red Count 1.2 11.5 30.2 -5.5 0.0 -1.5 -3.6 -1.9 -4.2 3.7
Blood White Count 0.2 1.6 6.7 0.9 0.0 -0.9 -0.8 -2.6 -0.5 1.3
Heel T-Score 5.3 41.8 84.6 -7.2 0.0 -3.6 -8.5 -4.8 -9.2 6.9
BMI 0.6 3.4 11.2 3.3 0.0 -0.7 1.1 -2.2 1.8 -1.7
Height 16.5 317.4 566.4 23.8 0.0 11.6 19.3 18.6 21.7 -18.2
Waist Hip Ratio (WHR) 1.3 5.9 11.7 -3.1 0.0 -2.0 -2.7 -1.1 -3.4 2.8
Systolic Blood Pressure 0.6 2.8 11.4 3.4 0.0 -0.2 0.7 2.2 1.5 -0.8
Smoking Status 0.1 0.3 2.3 0.0 0.0 0.2 0.0 -1.5 -0.1 -0.1
Allergy or Eczema 0.0 0.1 0.3 0.6 0.0 0.4 -0.1 0.1 -0.3 -0.5
Cardiovascular Disease 0.5 1.8 5.8 2.4 0.0 -0.6 0.9 -0.4 1.8 -1.5
Hypothyroidism (self reported) 0.6 1.5 4.6 2.1 0.0 -1.6 -1.3 -0.1 -0.9 0.9
Respiratory disease 0.1 0.2 0.4 0.4 0.0 -0.1 -0.5 0.7 -0.6 0.2
Type 2 Diabetes (T2D) (2018) 1.6 3.0 6.8 1.3 0.0 -2.3 -2.6 -1.5 -1.6 1.7
Lung FEV1/FVC ratio 0.5 2.8 6.6 0.2 0.0 -2.4 -2.6 0.2 -2.3 1.4
Lung FVC 0.4 2.1 7.8 -1.5 0.0 0.2 2.8 0.6 2.1 -0.0
Neuroticism 0.7 1.6 9.4 -0.2 0.0 -1.2 -0.6 -3.1 -0.3 0.1
Chronotype (morning person) 0.4 1.0 3.0 -1.4 0.0 0.2 -0.8 1.7 -0.9 0.6
Hair Pigment 30.5 869.8 2411.0 -49.1 0.0 -20.9 -26.2 -26.4 -32.5 28.3
Tanning 60.7 741.0 1989.2 44.6 0.0 21.6 23.9 25.7 29.4 -25.2
Hand grip strength (left) 1.7 4.6 11.8 3.4 0.0 0.1 1.6 3.1 2.1 -1.8
Number of treatments/medications taken 0.4 0.8 2.4 1.5 0.0 -1.1 -0.1 -1.1 0.2 1.0
Average weekly spirits intake 0.9 1.1 3.4 -1.0 0.0 1.8 0.6 -0.7 0.2 -1.5
Sensitivity / hurt feelings 0.5 0.9 3.4 1.0 0.0 0.1 0.6 -0.8 1.0 -1.9
Frequency of depressed mood in last 2 weeks 1.7 2.4 11.9 -1.6 0.0 -0.6 -0.9 -3.5 -1.0 0.2
Hearing difficulty/problems: Yes 0.2 0.3 0.6 -0.5 0.0 0.8 -0.3 0.5 -0.7 0.4
Relative age of first facial hair 0.3 0.6 1.2 -0.8 0.0 0.8 1.1 -1.0 0.7 -0.2
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 5.1 0.1 0.0 -0.5 0.4 -2.3 0.2 -0.6
Ever used hormone-replacement therapy (HRT) 0.6 0.8 3.3 1.8 0.0 0.4 0.3 1.3 0.7 -0.2
Ever had hysterectomy (womb removed) 3.2 3.6 8.0 2.6 0.0 2.0 1.5 1.3 1.5 -2.8
Systolic blood pressure, automated reading 0.5 1.3 7.7 2.8 0.0 -0.7 -0.6 0.9 0.2 0.2
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 1.7 0.7 0.0 0.2 0.4 1.3 0.8 -0.4
Angina 0.8 1.0 5.9 2.4 0.0 -0.5 -0.1 -0.6 0.6 0.5
Medication for hormone replacement therapy 0.3 0.4 1.4 0.5 0.0 1.2 0.7 0.5 0.4 -0.0
Vitamin and mineral supplements 0.2 0.3 0.9 -0.9 0.0 -0.2 0.6 -0.4 0.4 -0.4
Supplements: Zinc 2.3 2.5 4.2 1.7 0.0 2.1 1.7 1.1 1.8 -1.6
Medication: Co-codamol 0.7 0.8 2.2 0.6 0.0 1.5 1.0 -0.4 1.0 -1.0
Medication: Metformin 0.4 0.5 1.7 0.8 0.0 0.9 -0.6 -1.3 -0.3 -0.4
Diabetes (father) 0.1 0.1 0.3 0.1 0.0 0.2 -0.3 0.2 -0.1 0.5
Diabetes (mother) 0.2 0.3 1.6 1.2 0.0 -0.3 -0.2 -0.2 0.1 0.1
Severe depression (siblings) 0.2 0.2 1.0 1.0 0.0 -0.6 -0.5 -0.1 -0.2 0.1
Pack years adult smoking proportion 1.5 2.2 5.3 2.3 0.0 1.8 1.3 0.5 1.6 -1.7
Impedance of leg (right) 1.9 9.2 27.3 -5.2 0.0 -2.2 -3.2 -2.4 -3.2 2.5
Leg fat-free mass (left) 12.1 64.0 146.4 12.1 0.0 4.7 8.4 6.7 9.6 -8.5
Trunk fat percentage 0.7 3.0 6.7 2.6 0.0 -1.3 1.3 -1.6 2.2 -1.8
Hand grip strength (right) 2.9 7.9 18.3 4.3 0.0 0.1 2.3 4.1 3.1 -2.3
Townsend deprivation index at recruitment 0.5 0.6 1.3 0.7 0.0 0.6 1.2 -0.9 1.0 -0.6
Current tobacco smoking 1.2 2.0 9.0 -1.2 0.0 -0.4 -0.9 -3.0 -1.2 0.8
Average weekly fortified wine intake 1.1 1.3 3.9 -2.0 0.0 0.0 -1.3 0.2 -1.6 0.9
Maternal smoking around birth 2.7 4.0 10.0 2.0 0.0 3.2 1.9 1.2 1.8 -2.3
Fed-up feelings 1.3 2.4 10.4 -0.3 0.0 -1.7 -1.3 -3.2 -0.8 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.2 2.9 10.9 -1.4 0.0 -0.4 -1.6 -3.3 -1.7 1.5
Relative age voice broke 0.3 0.4 0.6 -0.8 0.0 0.6 0.7 -0.1 0.7 -0.8
Taking other prescription medications 1.1 1.7 3.2 1.7 0.0 1.1 1.8 -0.4 1.7 -1.2
Age when periods started (menarche) 0.5 1.3 5.8 1.1 0.0 -2.4 -0.5 1.0 0.2 0.9
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.6 1.3 0.0 -0.1 0.8 0.1 0.9 -1.3
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 4.2 -1.6 0.0 -0.8 -2.1 -1.4 -1.9 1.8
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 1.0 0.4 0.0 -0.0 -0.0 0.8 0.1 -1.0
Qualifications: CSEs or equivalent 0.2 0.3 1.3 -1.1 0.0 -0.6 -0.1 -0.2 -0.2 0.2
Serious illness, injury or assault to yourself 0.4 0.4 1.4 1.2 0.0 -0.5 0.2 -0.6 0.5 -0.9
High blood pressure 0.9 2.5 8.2 2.9 0.0 -0.8 1.3 0.2 2.0 -1.8
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.5 0.3 0.0 0.4 -0.4 0.4 -0.6 -0.7
Multivitamins +/- minerals 0.2 0.2 1.1 0.0 0.0 1.1 -0.3 0.2 -0.4 0.4
Stomach or abdominal pain in last month 0.4 0.6 1.1 -1.1 0.0 0.6 1.0 -0.1 0.9 -0.7
Supplements: Glucosamine 0.2 0.2 0.9 0.2 0.0 0.3 -0.9 -0.3 -0.6 -0.2
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 1.8 0.6 0.0 -1.3 -0.4 0.1 0.1 0.3
Medication: Atenolol 0.1 0.1 0.4 0.4 0.0 0.4 -0.3 -0.6 -0.4 -0.2
Medication: Levothyroxine sodium 0.6 1.1 2.8 1.7 0.0 -0.8 -0.8 -1.6 -0.4 0.6
Sitting height 13.9 98.8 225.0 15.0 0.0 5.7 9.8 10.4 11.6 -9.7
Chronic bronchitis/emphysema (father) 4.4 5.2 11.6 2.5 0.0 2.2 3.4 1.4 3.2 -1.4
High blood pressure (mother) 2.2 3.1 9.1 3.0 0.0 0.3 1.3 1.6 1.6 -2.3
Body mass index (BMI) 0.6 2.6 6.5 2.6 0.0 -0.5 1.0 -2.3 1.6 -1.6
Impedance of leg (left) 1.9 9.1 24.3 -4.9 0.0 -2.3 -3.2 -2.6 -3.2 2.6
Leg predicted mass (left) 12.1 64.2 146.4 12.1 0.0 4.8 8.5 6.8 9.6 -8.4
Trunk fat mass 3.3 14.4 37.6 6.1 0.0 0.5 3.9 1.0 5.1 -4.4
Waist circumference 1.8 6.6 18.2 4.3 0.0 0.3 2.8 0.1 3.5 -2.8
Number of incorrect matches in round 1.0 1.7 4.9 -1.1 0.0 2.2 1.9 0.7 1.0 -0.6
Past tobacco smoking 0.1 0.2 0.4 -0.2 0.0 -0.7 -0.5 -0.1 -0.6 0.1
Alcohol usually taken with meals 0.2 0.4 0.9 0.8 0.0 0.7 0.6 1.0 0.4 -0.4
Nervous feelings 1.8 3.3 15.0 -3.9 0.0 -0.9 -1.3 -1.7 -1.5 1.0
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 4.6 -1.2 0.0 0.7 0.0 -2.2 0.0 -0.5
Hearing difficulty/problems with background noise 0.9 1.4 4.6 -1.6 0.0 2.2 -0.4 1.0 -1.1 0.5
Hair/balding pattern: Pattern 2 2.5 3.2 10.9 -3.3 0.0 -0.9 -0.6 -2.4 -1.2 1.8
Had menopause 0.4 0.5 2.2 1.5 0.0 -0.1 -0.7 -0.1 -0.6 -0.3
Had other major operations 0.2 0.3 0.7 0.3 0.0 0.2 0.7 -0.4 0.7 -0.8
Forced vital capacity (FVC) 6.3 24.3 38.3 6.0 0.0 2.4 5.9 5.7 6.2 -4.8
Heel bone mineral density (BMD) T-score, automated (right) 1.6 3.8 6.6 -2.2 0.0 -1.5 -2.6 -1.4 -2.5 2.1
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 1.4 -0.0 0.0 1.2 0.4 -0.5 0.2 -0.8
Qualifications: None of the above 0.1 0.3 0.6 0.4 0.0 0.8 0.5 -0.7 0.6 0.1
Financial difficulties in last 2 years 1.3 1.7 5.0 2.2 0.0 1.8 1.4 -0.3 1.2 -0.6
Mouth/teeth dental problems 0.4 0.5 2.4 -1.5 0.0 0.6 -0.1 0.8 -0.5 0.3
Heart attack 0.9 1.2 4.4 2.1 0.0 0.8 1.1 -0.1 1.3 -0.4
Allergy 0.3 0.8 2.0 -1.4 0.0 -0.8 0.1 -1.3 0.1 1.0
Pain all over the body in last month 1.5 1.7 3.0 -0.8 0.0 -1.2 -1.4 -1.7 -1.4 1.5
Diabetes (self-reported) 0.4 0.7 1.9 1.4 0.0 -0.6 -1.2 -0.8 -0.4 -0.0
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.5 0.9 0.0 0.5 0.1 0.0 0.3 -1.2
Medication: Ramipril 1.0 1.2 3.1 1.0 0.0 -1.8 -0.9 -1.8 -0.4 0.7
Medication: Simvastatin 0.2 0.3 0.7 0.8 0.0 -0.3 -0.5 -0.8 -0.3 -0.4
Fluid intelligence score 0.3 0.5 2.3 0.4 0.0 -1.0 -0.2 -1.5 0.3 -0.2
Illnesses of siblings 0.5 0.6 2.9 -1.7 0.0 0.0 -0.5 0.5 -1.1 0.3
Neuroticism score 1.4 2.8 12.0 -1.8 0.0 -1.1 -1.3 -3.5 -1.2 0.4
Weight 8.2 40.4 101.2 10.1 0.0 2.9 6.7 4.0 8.0 -7.0
Impedance of arm (right) 1.3 6.1 20.9 -4.6 0.0 -1.6 -2.0 0.1 -2.6 2.9
Arm fat percentage (right) 0.4 1.5 6.8 0.6 0.0 -1.7 0.1 -2.6 0.6 -0.6
Trunk fat-free mass 15.2 87.1 187.7 13.7 0.0 6.1 9.7 8.8 11.0 -9.6
Hip circumference 6.4 27.7 68.2 8.3 0.0 2.0 5.7 2.0 7.1 -5.8
Time employed in main current job 0.4 0.4 1.6 0.1 0.0 -0.7 0.2 0.9 0.3 1.3
Alcohol intake versus 10 years previously 0.2 0.4 0.5 0.6 0.0 0.5 0.7 0.7 0.7 -0.7
Father’s age at death 1.9 2.5 6.6 1.1 0.0 1.9 1.4 2.6 1.4 -1.4
Worrier / anxious feelings 0.4 0.7 1.5 0.4 0.0 -1.2 -1.2 -0.9 -0.7 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 4.4 0.2 0.0 -0.6 0.3 -2.1 0.5 0.2
Falls in the last year 1.8 2.5 5.5 -0.1 0.0 -1.9 -2.3 -1.3 -2.0 1.7
Hair/balding pattern: Pattern 3 0.3 0.4 1.1 0.5 0.0 -0.8 -1.0 0.3 -0.7 0.6
Number of live births 0.3 0.5 1.4 -0.4 0.0 -0.7 -0.3 1.1 -0.1 1.2
Forced expiratory volume in 1-second (FEV1) 3.4 11.4 20.0 4.3 0.0 0.9 3.7 4.5 4.0 -3.2
Pulse rate 1.6 2.7 5.8 1.2 0.0 1.2 2.0 2.3 2.4 -0.9
Happiness 0.5 0.6 1.5 -0.5 0.0 -1.0 -1.0 -1.2 -0.9 0.3
Noisy workplace 1.9 2.4 8.8 -1.9 0.0 3.0 1.3 1.1 0.5 -1.1
Qualifications: A levels/AS levels or equivalent 0.9 1.9 3.3 1.5 0.0 -0.4 1.7 1.7 1.8 -1.5
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.6 -0.2 0.0 -0.2 0.1 -0.8 -0.4 0.3
Mouth/teeth dental problems: Dentures 1.0 1.8 4.1 2.0 0.0 1.0 1.1 1.3 1.4 -1.5
Asthma 0.1 0.2 0.9 0.2 0.0 0.8 0.3 0.9 0.1 -0.0
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.7 4.2 -0.6 0.0 -0.9 -1.7 -1.8 -2.1 0.8
Medication: Cholesterol lowering 0.6 0.9 2.7 1.6 0.0 -1.4 -0.8 -0.9 -0.1 0.5
Depression (self-reported) 1.8 2.2 3.7 1.6 0.0 1.4 1.5 -1.6 1.5 -1.9
Medication: Lansoprazole 0.6 0.7 1.8 -0.5 0.0 -1.4 -1.0 -1.2 -0.6 0.2
Prospective memory result 1.6 2.0 5.1 1.5 0.0 2.3 1.0 1.9 0.8 -1.1
Lung cancer (father) 0.9 1.0 4.4 -0.5 0.0 1.2 -0.2 2.1 -0.7 0.8
Illnesses of mother 0.3 0.4 0.7 -0.8 0.0 0.7 -0.6 -0.1 -0.8 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 3.9 12.5 23.2 4.4 0.0 1.3 3.9 4.8 4.1 -3.4
Pulse wave Arterial Stiffness index 0.2 0.3 1.0 1.0 0.0 0.1 0.6 0.4 0.6 0.0
Impedance of arm (left) 1.3 6.2 20.7 -4.5 0.0 -1.9 -2.1 -0.3 -2.6 2.8
Arm fat mass (right) 1.9 7.8 22.0 4.7 0.0 0.2 2.8 -0.1 3.7 -3.3
Trunk predicted mass 15.0 85.8 185.0 13.6 0.0 6.1 9.6 8.8 10.9 -9.6
Standing height 15.7 155.5 297.2 17.2 0.0 7.6 13.0 13.9 14.7 -12.4
Length of working week for main job 0.1 0.1 0.2 0.5 0.0 -0.3 -0.2 -0.1 -0.2 0.4
Exposure to tobacco smoke at home 0.4 0.4 1.5 -1.2 0.0 0.4 -0.2 -0.8 -0.5 0.5
Breastfed as a baby 0.1 0.2 0.6 -0.3 0.0 0.8 0.0 0.1 -0.2 -0.6
Tense / ‘highly strung’ 0.2 0.3 1.1 -0.8 0.0 0.2 0.3 -1.0 0.0 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 2.9 -0.3 0.0 1.5 1.7 -1.4 1.7 -1.2
Hair/balding pattern: Pattern 4 1.0 2.3 6.4 -1.0 0.0 -1.3 -2.5 0.3 -2.4 1.2
Birth weight of first child 0.5 0.9 2.8 -0.9 0.0 -1.7 -0.9 -1.1 -0.6 0.5
Peak expiratory flow (PEF) 1.3 3.0 7.7 2.2 0.0 0.4 1.7 2.8 1.8 -1.5
Pulse wave reflection index 0.2 0.3 1.3 0.2 0.0 -0.4 0.0 -0.2 -0.5 1.2
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.4 -0.4 0.0 1.2 -0.5 -0.1 -0.8 -0.1
Loud music exposure frequency 0.5 0.6 2.8 -0.2 0.0 1.0 0.3 -1.7 0.3 -0.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.6 0.9 0.0 -0.9 0.4 0.1 0.6 -1.3
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.9 0.1 0.0 -0.7 0.2 -1.4 0.5 0.3
Blood clot in the leg (DVT) 4.5 5.8 18.5 4.3 0.0 0.3 1.3 3.4 2.2 -2.0
Medication: Paracetamol 0.2 0.3 1.1 0.2 0.0 -0.7 0.2 -1.1 0.2 -0.2
Headache pain in last month 3.2 5.5 10.4 3.2 0.0 1.1 2.8 2.3 2.9 -2.2
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 4.9 -2.2 0.0 1.7 0.5 1.0 -0.5 -0.1
Glaucoma (self-reported) 3.0 3.6 8.5 2.9 0.0 1.5 1.4 1.9 1.8 -2.4
Gout (self-reported) 0.1 0.1 0.6 0.3 0.0 0.8 0.2 0.3 -0.0 -0.1
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 3.7 1.9 0.0 -1.1 -1.0 -1.1 -0.6 0.4
Medication: Amlodipine 1.0 1.5 3.7 1.2 0.0 0.3 1.7 1.1 1.9 -0.8
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.2 -1.1 0.0 0.2 -0.1 -0.3 -0.9 1.0
Birth weight 0.8 1.8 7.2 1.7 0.0 -0.4 0.6 2.7 1.2 -0.5
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.2 1.1 0.0 -0.0 0.5 0.8 0.9 -0.6
High blood pressure (siblings) 1.2 1.8 7.8 2.8 0.0 0.3 1.0 0.5 1.5 -1.0
Forced vital capacity (FVC), Best measure 7.3 26.6 42.0 6.0 0.0 2.8 6.2 6.3 6.5 -4.8
Body fat percentage 0.6 2.3 7.2 1.6 0.0 -1.7 0.5 -2.7 1.4 -1.3
Leg fat percentage (right) 0.8 3.0 16.3 0.1 0.0 -1.9 -0.8 -4.0 0.0 -0.7
Arm fat-free mass (right) 13.6 69.7 166.4 12.9 0.0 4.9 8.5 6.7 9.9 -9.0
Exposure to tobacco smoke outside home 0.7 1.0 2.9 -0.7 0.0 -0.9 -1.2 -1.7 -1.1 0.2
Comparative body size at age 10 1.8 4.9 12.3 1.2 0.0 2.6 2.3 1.2 2.6 -3.5
Number of full brothers 0.5 0.7 2.8 0.2 0.0 1.2 0.4 1.7 0.3 -0.4
Worry too long after embarrassment 1.9 3.2 7.5 -1.9 0.0 -1.9 -1.7 -2.7 -1.7 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.5 2.0 3.8 1.0 0.0 1.4 1.8 -0.7 1.8 -2.0
Wheeze or whistling in the chest in last year 0.2 0.4 0.9 0.8 0.0 -0.6 -0.8 -0.9 -0.3 0.3
Number of children fathered 0.7 0.8 2.0 0.1 0.0 -0.6 -1.4 1.4 -1.1 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.4 0.8 0.0 -0.0 1.1 1.1 1.2 -0.2
Age at first live birth 0.5 0.9 2.6 -1.1 0.0 -1.6 -1.0 -0.0 -0.6 1.1
Pulse wave peak to peak time 0.1 0.1 0.3 -0.1 0.0 0.2 0.1 0.2 0.3 -0.6
Health satisfaction 0.1 0.2 0.9 0.9 0.0 0.4 -0.3 0.2 0.1 -0.1
Shortness of breath walking on level ground 0.1 0.2 0.6 0.4 0.0 0.8 -0.2 -0.1 -0.2 -0.5
Qualifications: College or University degree 0.2 0.7 2.2 1.2 0.0 -0.3 0.1 1.5 0.9 -0.0
Eye problems/disorders: None of the above 0.7 0.8 2.4 -0.9 0.0 1.5 1.0 -0.2 0.4 -1.1
Mouth/teeth dental problems: Loose teeth 1.4 1.6 4.4 0.9 0.0 2.1 1.2 -0.5 1.2 -1.8
Emphysema/chronic bronchitis 0.1 0.1 0.3 -0.3 0.0 0.2 -0.6 -0.2 -0.6 -0.1
Medication for pain relief, constipation, heartburn 0.9 1.6 5.1 0.6 0.0 1.4 1.2 2.3 1.1 -1.0
Neck or shoulder pain in last month 0.3 0.4 1.1 -0.9 0.0 -0.0 -0.8 -0.4 -1.0 0.4
Medication: Blood pressure 0.9 1.6 5.6 2.4 0.0 -2.0 0.3 -0.4 1.1 -0.5
Angina (self-reported) 0.8 1.1 6.6 2.6 0.0 -0.2 0.0 -0.6 0.8 0.3
Migraine (self-reported) 1.2 1.5 4.3 2.1 0.0 0.2 1.2 0.3 1.3 -1.8
Medication: Ibuprofen 1.0 1.1 3.0 0.3 0.0 -1.0 -1.6 -1.1 -1.7 0.5
Medication: Allopurinol 1.2 1.6 2.7 1.6 0.0 1.6 1.0 1.6 0.9 -1.2
Medication: Omeprazole 0.4 0.5 0.8 0.1 0.0 0.8 0.8 0.9 0.8 0.9
Medication: Seretide 50 evohaler 0.1 0.1 0.6 -0.8 0.0 -0.1 -0.1 -0.3 -0.4 0.3
Mean time to correctly identify matches 0.3 0.6 2.1 -1.4 0.0 0.4 -0.4 0.7 -0.5 1.0
Heart disease (mother) 0.1 0.1 0.2 -0.1 0.0 -0.0 0.4 0.3 0.4 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.3 -1.1 0.0 -0.4 -1.1 -0.6 -1.0 0.1
Whole body fat mass 2.7 11.2 31.0 5.6 0.0 0.3 3.4 0.2 4.5 -4.0
Leg fat mass (right) 2.1 8.1 21.5 4.6 0.0 0.2 2.6 -0.9 3.7 -3.7
Arm predicted mass (right) 13.6 69.7 164.7 12.8 0.0 5.0 8.5 6.7 10.0 -9.1
Pulse rate, automated reading 0.3 1.1 2.0 1.2 0.0 0.9 1.2 1.3 1.4 -0.2
Alcohol intake frequency. 0.8 1.8 4.6 -1.2 0.0 -2.1 -0.6 -1.8 -1.0 1.3
Comparative height size at age 10 11.5 63.6 102.0 10.1 0.0 5.1 8.9 8.8 9.7 -8.2
Number of full sisters 0.8 1.0 4.0 -0.0 0.0 -2.0 -0.7 -1.3 -0.1 0.7
Suffer from ‘nerves’ 0.9 1.4 2.8 -0.5 0.0 -1.4 -1.5 -1.7 -1.5 0.7
Overall health rating 0.3 0.7 1.3 1.0 0.0 0.7 0.6 -0.9 0.9 -1.1
Chest pain or discomfort 0.1 0.2 0.5 0.7 0.0 0.6 0.4 0.1 0.6 0.3
Had major operations 0.5 0.6 2.2 1.5 0.0 -0.2 0.6 -0.0 0.9 -0.7
Age at last live birth 0.2 0.3 1.0 0.2 0.0 -0.4 0.5 0.9 1.0 0.0
Family relationship satisfaction 0.2 0.2 0.5 0.3 0.0 -0.4 -0.5 0.4 -0.6 0.7
Leg pain on walking 0.3 0.4 1.8 0.3 0.0 1.3 -0.4 0.3 -0.6 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 2.4 -1.5 0.0 -0.3 -0.7 0.4 -1.0 0.2
Commuting to job workplace: Car/motor vehicle 0.8 0.9 4.1 0.2 0.0 -1.2 0.1 -2.0 0.5 0.5
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 -0.4 0.0 -0.2 -0.4 0.3 0.1 0.2
Medication: Aspirin 1.0 1.3 4.7 0.7 0.0 -1.6 -1.0 -2.2 -0.5 0.8
Supplements: Vitamin C 0.2 0.2 0.8 0.3 0.0 -0.6 -0.2 0.9 0.1 0.0
Knee pain experienced in last month 2.6 4.0 7.1 -2.7 0.0 -1.3 -1.7 -2.6 -2.0 2.4
Hypertension (Self-reported) 0.6 1.8 5.2 2.3 0.0 -1.0 1.1 -0.1 1.7 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.6 4.6 -2.1 0.0 -0.6 -1.5 0.0 -1.0 1.7
Illnesses of father: Heart disease 0.4 0.6 2.4 -0.3 0.0 -0.9 -0.4 -1.5 -0.5 0.8
Illnesses of siblings: Diabetes 0.3 0.4 1.6 1.3 0.0 -0.4 0.2 -0.7 0.5 0.2
Smoking status: Previous 0.7 1.0 1.7 1.1 0.0 1.1 1.1 1.0 1.3 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 14.1 29.3 51.9 7.2 0.0 3.4 6.0 4.6 6.9 -6.0
Whole body fat-free mass 14.4 82.2 182.2 13.5 0.0 5.7 9.5 8.1 10.8 -9.4
Leg fat-free mass (right) 12.8 68.5 156.2 12.5 0.0 5.0 8.8 7.0 9.9 -8.5
Arm fat percentage (left) 0.4 1.7 7.9 0.6 0.0 -1.7 0.1 -2.8 0.6 -0.7
Average weekly red wine intake 0.4 0.5 2.2 1.1 0.0 -0.1 -0.1 1.5 0.1 -0.5
Handedness (chirality/laterality): Left-handed 1.5 1.8 5.8 -1.1 0.0 2.4 1.0 1.5 0.5 -1.3
Mood swings 1.0 1.7 5.4 -1.4 0.0 -0.6 -1.6 -2.3 -1.4 0.2
Loneliness, isolation 1.5 2.1 9.5 -2.0 0.0 -0.2 -0.6 -3.1 -0.9 0.2
Long-standing illness, disability or infirmity 1.2 1.8 6.4 2.5 0.0 0.2 1.4 0.1 1.6 -1.3
Ever had bowel cancer screening 0.1 0.1 0.3 -0.0 0.0 -0.2 -0.5 -0.1 -0.4 0.1
Diabetes diagnosed by doctor 0.7 1.1 2.5 1.4 0.0 -1.3 -1.6 -1.1 -0.6 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 2.1 0.4 0.0 1.5 0.6 -0.7 0.5 0.1
Friendships satisfaction 0.6 0.8 2.4 0.5 0.0 -1.6 -0.8 -1.4 -0.4 0.0
Qualifications: nursing, teaching 0.2 0.3 0.8 0.1 0.0 0.7 0.9 -0.2 0.8 -0.6
Commuting to job workplace: Walk 1.3 1.4 5.6 0.0 0.0 1.2 1.4 2.4 0.8 0.2
Eye problems/disorders: Cataract 2.1 2.5 5.6 -0.3 0.0 -2.1 -2.1 -0.8 -1.4 2.4
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.4 -0.4 0.0 -1.3 -1.1 -0.6 -1.1 1.5
Medication for cholesterol 0.2 0.3 1.1 -0.9 0.0 0.4 0.1 1.0 0.0 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.5 2.9 5.2 0.1 0.0 2.3 2.2 1.3 2.1 -2.0
Back pain experienced in last month 0.3 0.4 1.2 1.1 0.0 0.5 0.5 -0.1 0.7 -0.7
Mineral and other dietary supplements 0.4 0.5 1.1 -0.2 0.0 -0.9 0.9 -1.1 0.9 -0.3
Breast cancer (self-reported) 0.6 0.7 2.8 -1.7 0.0 -0.8 -0.5 -0.4 -1.0 0.4
Asthma (self-reported) 0.2 0.3 1.0 0.3 0.0 0.9 0.4 1.0 0.2 -0.5
Osteoporosis (self-reported) 1.3 1.6 4.2 0.3 0.0 1.4 2.0 1.4 1.7 -0.3
Osteoarthritis (self-reported) 1.7 2.1 4.4 -0.2 0.0 -1.5 -1.5 -1.7 -1.7 2.1
Medication: Aspirin 0.8 1.1 4.1 0.4 0.0 -1.2 -0.9 -2.0 -0.5 1.0
Medication: Gliclazide 0.2 0.2 0.6 -0.1 0.0 0.3 -0.8 0.6 -0.5 0.3
Illnesses of father: None of the above (group 1) 0.4 0.4 0.8 0.3 0.0 -0.7 -0.9 0.7 -0.9 0.7
Smoking status: Current 1.3 2.0 6.8 -1.6 0.0 -0.7 -1.1 -2.6 -1.5 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 2.2 -0.8 0.0 -1.5 -0.4 -0.2 -0.7 1.4
Whole body water mass 14.4 82.3 182.2 13.5 0.0 5.7 9.4 8.1 10.8 -9.5
Leg predicted mass (right) 12.8 68.1 153.8 12.4 0.0 5.0 8.8 7.1 9.9 -8.5
Arm fat mass (left) 1.9 7.8 22.4 4.7 0.0 0.1 2.7 -0.0 3.7 -3.3
Number of self-reported non-cancer illnesses 0.7 1.3 6.4 2.5 0.0 -0.5 0.3 0.2 1.1 -0.8
Average weekly champagne plus white wine intake 2.2 3.0 6.9 1.3 0.0 2.6 1.9 2.3 1.4 -1.2
Miserableness 0.5 0.9 2.8 0.1 0.0 0.6 0.8 -1.7 0.9 -1.1
Guilty feelings 0.6 0.9 2.1 -0.1 0.0 -1.1 -1.5 -1.3 -1.1 -0.4
Wears glasses or contact lenses 2.8 3.2 6.9 -2.6 0.0 -1.2 -2.0 -0.6 -2.6 1.7
Ever taken oral contraceptive pill 0.2 0.2 0.6 0.7 0.0 0.0 0.0 0.8 0.5 0.2
Hearing aid user 0.4 0.4 1.3 -0.6 0.0 -0.4 -0.0 1.1 -0.3 1.0
Mother’s age at death 0.2 0.3 0.9 -1.0 0.0 0.6 -0.1 0.7 0.0 -0.3
Financial situation satisfaction 1.4 1.7 3.2 0.9 0.0 1.8 1.6 0.9 1.4 -1.6
Tinnitus: Yes, now most or all of the time 1.3 1.5 4.9 -1.1 0.0 -1.7 -0.9 -0.1 -1.0 2.2
Commuting to job workplace: Public transport 0.6 0.7 3.0 -0.8 0.0 0.5 0.5 1.7 0.2 -1.0
Eye problems/disorders: Glaucoma 1.5 1.8 4.8 2.2 0.0 0.8 0.9 2.0 1.0 -1.0
Medication: Blood pressure 0.3 0.5 1.8 1.3 0.0 -0.6 0.2 -1.1 0.2 -0.2
Pain type(s) experienced in last month: Hip pain 1.3 1.6 7.7 -0.8 0.0 2.8 1.1 -0.9 0.7 -0.7
Supplements: Fish oil (including cod liver oil) 2.3 3.0 7.5 -1.4 0.0 -0.5 -2.4 0.5 -2.7 2.3
High cholesterol (Self-reported) 0.9 1.5 3.0 1.4 0.0 -1.3 -1.7 -1.7 -1.0 0.6
Medication: Bendroflumethiazide 0.5 0.8 4.2 1.1 0.0 -2.0 -0.3 0.2 0.4 -0.3
Medication: Paracetamol 0.1 0.2 0.5 0.7 0.0 -0.7 -0.6 -0.2 -0.4 0.1
Medication: Lisinopril 0.3 0.4 1.9 1.4 0.0 -0.6 0.1 -0.2 0.6 0.2
Medication: Atorvastatin 1.1 1.4 7.7 2.8 0.0 -0.8 -0.2 0.7 0.7 -0.4
Illnesses of father: High blood pressure 1.2 1.5 2.9 1.1 0.0 0.6 1.6 1.2 1.5 -1.7
Alcohol drinker status: Never 0.3 0.4 1.8 0.7 0.0 -1.3 0.1 -0.6 0.2 0.4
Ever smoked 0.1 0.2 0.5 -0.6 0.0 0.7 0.3 -0.3 0.2 -0.2
Basal metabolic rate 13.1 72.6 163.8 12.8 0.0 5.1 8.9 7.1 10.3 -9.0
Leg fat percentage (left) 0.9 3.1 16.8 0.5 0.0 -2.0 -0.8 -4.1 0.1 -0.6
Arm fat-free mass (left) 12.4 62.9 152.1 12.3 0.0 4.7 8.0 6.5 9.4 -8.4
Number of operations (self-reported) 0.9 1.3 3.2 1.6 0.0 -0.0 1.3 -0.4 1.8 -1.3
Average weekly beer plus cider intake 0.1 0.2 0.6 0.8 0.0 -0.0 0.3 -0.3 0.6 0.4
Irritability 2.1 3.6 8.0 -2.6 0.0 -1.2 -1.5 -2.8 -1.7 1.8
Risk taking 0.3 0.5 2.6 1.6 0.0 -0.5 -0.1 0.3 0.3 -0.6
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.1 -0.2 0.0 -1.0 -0.7 -0.9 -0.7 0.5
Fractured/broken bones in last 5 years 0.2 0.3 1.0 1.0 0.0 0.0 -0.6 -0.4 -0.5 0.6
Age started oral contraceptive pill 3.4 4.3 9.9 -1.8 0.0 -1.3 -2.7 -0.1 -2.8 3.1
Diastolic blood pressure, automated reading 1.5 4.8 13.7 3.7 0.0 0.1 2.3 1.6 2.9 -1.8
Ever depressed for a whole week 0.9 1.2 2.0 0.9 0.0 1.4 1.1 0.9 1.3 -1.3
Unable to work because of sickness or disability 0.8 1.1 2.5 -0.6 0.0 0.4 1.5 -0.6 1.6 -1.3
Commuting to job workplace: Cycle 1.2 1.5 4.4 1.0 0.0 2.1 1.1 1.6 0.6 -1.0
Myopia 1.6 2.4 4.6 1.6 0.0 1.2 2.1 1.2 2.1 -1.4
Vascular/heart problems diagnosed by doctor 1.0 2.7 11.0 -3.3 0.0 0.6 -1.3 0.2 -2.1 1.4
Cholesterol lowering medication 0.5 0.7 2.6 1.6 0.0 -0.3 -0.6 -0.7 -0.0 -1.1
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 2.2 0.4 0.0 1.2 1.4 1.2 1.5 0.4
Pain experienced in last month 0.1 0.1 0.4 0.2 0.0 -0.2 0.3 0.0 0.6 -0.6
Supplements: Calcium 0.7 0.8 2.3 0.4 0.0 0.9 1.0 0.4 1.1 -1.5
Basal cell carcinoma (self-reported) 2.1 2.6 9.9 -3.2 0.0 -0.4 -1.0 -1.4 -1.7 1.4
Heart attack/myocardial infarction (self-reported) 1.2 1.6 6.5 2.6 0.0 0.7 1.2 0.4 1.5 -0.5
Deep venous thrombosis (DVT) (self-reported) 4.4 5.7 17.1 4.1 0.0 0.4 1.4 3.4 2.2 -2.1
Heart disease (siblings) 0.2 0.3 0.6 -0.5 0.0 0.2 -0.8 -0.6 -0.7 0.4
Alcohol drinker status: Previous 0.5 0.5 2.3 1.5 0.0 -0.2 0.7 0.5 0.7 0.0
Pack years of smoking 1.1 1.6 3.3 1.8 0.0 1.8 1.1 0.3 1.3 -1.3
Impedance of whole body 1.9 9.6 27.2 -5.2 0.0 -2.5 -3.2 -1.6 -3.4 3.1
Leg fat mass (left) 2.3 8.9 24.7 5.0 0.0 0.2 2.7 -0.8 3.9 -3.8
Arm predicted mass (left) 12.8 64.8 153.8 12.4 0.0 5.0 8.1 6.5 9.6 -8.7