TWAS hub - E2F1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.062	0.0320	1.2e-03	0.008	0.017	0.013	0.02	0.019	3.0e-02	0.0028	7.9e-03	0.0016	2.0e-03
2	GTEx	Artery Tibial	0.270	0.0985	2.6e-03	-0.003	NA	-0.002	NA	-0.002	6.0e-01	NA	4.9e-01	NA	5.5e-01
3	GTEx	Brain Cortex	0.217	0.0920	8.9e-04	0.142	NA	0.100	NA	0.133	1.0e-04	NA	1.0e-03	NA	1.7e-04
4	GTEx	Brain Hippocampus	0.391	0.1074	6.8e-06	0.253	NA	0.182	NA	0.185	1.2e-06	NA	4.7e-05	NA	4.1e-05
5	GTEx	Brain Hypothalamus	0.261	0.1100	2.2e-03	0.020	NA	0.013	NA	0.121	1.1e-01	NA	1.6e-01	NA	9.1e-04
6	GTEx	Brain Putamen basal ganglia	0.180	0.0690	5.0e-04	0.215	NA	0.163	NA	0.206	7.7e-06	NA	1.1e-04	NA	1.2e-05
7	GTEx	Esophagus Mucosa	0.071	0.0360	2.4e-03	0.037	NA	0.027	NA	0.027	1.6e-03	NA	5.8e-03	NA	5.9e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5	6	7
Tanning	60.7	741.0	1989.2	44.6	21.6	23.9	25.7	29.4	-25.2
Hair Pigment	30.5	869.8	2411.0	-49.1	-20.9	-26.2	-26.4	-32.5	28.3
Height	16.5	317.4	566.4	23.8	11.6	19.3	18.6	21.7	-18.2
Standing height	15.7	155.5	297.2	17.2	7.6	13.0	13.9	14.7	-12.4
Trunk fat-free mass	15.2	87.1	187.7	13.7	6.1	9.7	8.8	11.0	-9.6
Trunk predicted mass	15.0	85.8	185.0	13.6	6.1	9.6	8.8	10.9	-9.6
Whole body fat-free mass	14.4	82.2	182.2	13.5	5.7	9.5	8.1	10.8	-9.4
Whole body water mass	14.4	82.3	182.2	13.5	5.7	9.4	8.1	10.8	-9.5
Forced expiratory volume in 1-second (FEV1), predicted	14.1	29.3	51.9	7.2	3.4	6.0	4.6	6.9	-6.0
Sitting height	13.9	98.8	225.0	15.0	5.7	9.8	10.4	11.6	-9.7
Arm fat-free mass (right)	13.6	69.7	166.4	12.9	4.9	8.5	6.7	9.9	-9.0
Arm predicted mass (right)	13.6	69.7	164.7	12.8	5.0	8.5	6.7	10.0	-9.1
Basal metabolic rate	13.1	72.6	163.8	12.8	5.1	8.9	7.1	10.3	-9.0
Leg fat-free mass (right)	12.8	68.5	156.2	12.5	5.0	8.8	7.0	9.9	-8.5
Leg predicted mass (right)	12.8	68.1	153.8	12.4	5.0	8.8	7.1	9.9	-8.5
Arm predicted mass (left)	12.8	64.8	153.8	12.4	5.0	8.1	6.5	9.6	-8.7
Arm fat-free mass (left)	12.4	62.9	152.1	12.3	4.7	8.0	6.5	9.4	-8.4
Leg fat-free mass (left)	12.1	64.0	146.4	12.1	4.7	8.4	6.7	9.6	-8.5
Leg predicted mass (left)	12.1	64.2	146.4	12.1	4.8	8.5	6.8	9.6	-8.4
Comparative height size at age 10	11.5	63.6	102.0	10.1	5.1	8.9	8.8	9.7	-8.2
Weight	8.2	40.4	101.2	10.1	2.9	6.7	4.0	8.0	-7.0
Forced vital capacity (FVC), Best measure	7.3	26.6	42.0	6.0	2.8	6.2	6.3	6.5	-4.8
Hip circumference	6.4	27.7	68.2	8.3	2.0	5.7	2.0	7.1	-5.8
Forced vital capacity (FVC)	6.3	24.3	38.3	6.0	2.4	5.9	5.7	6.2	-4.8
Heel T-Score	5.3	41.8	84.6	-7.2	-3.6	-8.5	-4.8	-9.2	6.9
Blood clot in the leg (DVT)	4.5	5.8	18.5	4.3	0.3	1.3	3.4	2.2	-2.0
Chronic bronchitis/emphysema (father)	4.4	5.2	11.6	2.5	2.2	3.4	1.4	3.2	-1.4
Deep venous thrombosis (DVT) (self-reported)	4.4	5.7	17.1	4.1	0.4	1.4	3.4	2.2	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	3.9	12.5	23.2	4.4	1.3	3.9	4.8	4.1	-3.4
Depression (Nagel 2018)	3.6	5.4	16.0	-1.5	-2.0	-2.5	-4.0	-2.3	1.9
Forced expiratory volume in 1-second (FEV1)	3.4	11.4	20.0	4.3	0.9	3.7	4.5	4.0	-3.2
Age started oral contraceptive pill	3.4	4.3	9.9	-1.8	-1.3	-2.7	-0.1	-2.8	3.1
Trunk fat mass	3.3	14.4	37.6	6.1	0.5	3.9	1.0	5.1	-4.4
Primary Biliary Cirrhosis	3.2	4.5	8.8	3.0	1.1	2.6	1.6	2.9	-2.0
Ever had hysterectomy (womb removed)	3.2	3.6	8.0	2.6	2.0	1.5	1.3	1.5	-2.8
Headache pain in last month	3.2	5.5	10.4	3.2	1.1	2.8	2.3	2.9	-2.2
Glaucoma (self-reported)	3.0	3.6	8.5	2.9	1.5	1.4	1.9	1.8	-2.4
Hand grip strength (right)	2.9	7.9	18.3	4.3	0.1	2.3	4.1	3.1	-2.3
Wears glasses or contact lenses	2.8	3.2	6.9	-2.6	-1.2	-2.0	-0.6	-2.6	1.7
Maternal smoking around birth	2.7	4.0	10.0	2.0	3.2	1.9	1.2	1.8	-2.3
Whole body fat mass	2.7	11.2	31.0	5.6	0.3	3.4	0.2	4.5	-4.0
Fasting Glucose	2.6	3.1	7.9	-0.4	-1.5	-2.8	0.1	-2.8	1.8
Knee pain experienced in last month	2.6	4.0	7.1	-2.7	-1.3	-1.7	-2.6	-2.0	2.4
Hair/balding pattern: Pattern 2	2.5	3.2	10.9	-3.3	-0.9	-0.6	-2.4	-1.2	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	2.9	5.2	0.1	2.3	2.2	1.3	2.1	-2.0
Supplements: Zinc	2.3	2.5	4.2	1.7	2.1	1.7	1.1	1.8	-1.6
Supplements: Fish oil (including cod liver oil)	2.3	3.0	7.5	-1.4	-0.5	-2.4	0.5	-2.7	2.3
Leg fat mass (left)	2.3	8.9	24.7	5.0	0.2	2.7	-0.8	3.9	-3.8
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	2.9	10.9	-1.4	-0.4	-1.6	-3.3	-1.7	1.5
High blood pressure (mother)	2.2	3.1	9.1	3.0	0.3	1.3	1.6	1.6	-2.3
Average weekly champagne plus white wine intake	2.2	3.0	6.9	1.3	2.6	1.9	2.3	1.4	-1.2
Type 2 Diabetes (T2D) (2012)	2.1	2.4	5.3	-1.5	-2.2	-1.6	-0.6	-1.4	2.3
Blood Platelet Count	2.1	24.1	37.3	-6.0	-3.8	-6.0	-3.9	-6.1	5.5
Leg fat mass (right)	2.1	8.1	21.5	4.6	0.2	2.6	-0.9	3.7	-3.7
Eye problems/disorders: Cataract	2.1	2.5	5.6	-0.3	-2.1	-2.1	-0.8	-1.4	2.4
Irritability	2.1	3.6	8.0	-2.6	-1.2	-1.5	-2.8	-1.7	1.8
Basal cell carcinoma (self-reported)	2.1	2.6	9.9	-3.2	-0.4	-1.0	-1.4	-1.7	1.4
Alzheimer’s Disease (in mother)	1.9	2.3	5.1	-1.2	-1.9	-2.2	-0.7	-2.0	0.9
Impedance of leg (right)	1.9	9.2	27.3	-5.2	-2.2	-3.2	-2.4	-3.2	2.5
Impedance of leg (left)	1.9	9.1	24.3	-4.9	-2.3	-3.2	-2.6	-3.2	2.6
Father’s age at death	1.9	2.5	6.6	1.1	1.9	1.4	2.6	1.4	-1.4
Noisy workplace	1.9	2.4	8.8	-1.9	3.0	1.3	1.1	0.5	-1.1
Arm fat mass (right)	1.9	7.8	22.0	4.7	0.2	2.8	-0.1	3.7	-3.3
Worry too long after embarrassment	1.9	3.2	7.5	-1.9	-1.9	-1.7	-2.7	-1.7	1.2
Arm fat mass (left)	1.9	7.8	22.4	4.7	0.1	2.7	-0.0	3.7	-3.3
Impedance of whole body	1.9	9.6	27.2	-5.2	-2.5	-3.2	-1.6	-3.4	3.1
Lupus	1.8	2.8	5.2	2.0	1.4	1.9	2.3	2.1	-0.7
Waist circumference	1.8	6.6	18.2	4.3	0.3	2.8	0.1	3.5	-2.8
Nervous feelings	1.8	3.3	15.0	-3.9	-0.9	-1.3	-1.7	-1.5	1.0
Falls in the last year	1.8	2.5	5.5	-0.1	-1.9	-2.3	-1.3	-2.0	1.7
Depression (self-reported)	1.8	2.2	3.7	1.6	1.4	1.5	-1.6	1.5	-1.9
Comparative body size at age 10	1.8	4.9	12.3	1.2	2.6	2.3	1.2	2.6	-3.5
Hand grip strength (left)	1.7	4.6	11.8	3.4	0.1	1.6	3.1	2.1	-1.8
Frequency of depressed mood in last 2 weeks	1.7	2.4	11.9	-1.6	-0.6	-0.9	-3.5	-1.0	0.2
Osteoarthritis (self-reported)	1.7	2.1	4.4	-0.2	-1.5	-1.5	-1.7	-1.7	2.1
Type 2 Diabetes (T2D) (2018)	1.6	3.0	6.8	1.3	-2.3	-2.6	-1.5	-1.6	1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.8	6.6	-2.2	-1.5	-2.6	-1.4	-2.5	2.1
Pulse rate	1.6	2.7	5.8	1.2	1.2	2.0	2.3	2.4	-0.9
Prospective memory result	1.6	2.0	5.1	1.5	2.3	1.0	1.9	0.8	-1.1
Myopia	1.6	2.4	4.6	1.6	1.2	2.1	1.2	2.1	-1.4
Pack years adult smoking proportion	1.5	2.2	5.3	2.3	1.8	1.3	0.5	1.6	-1.7
Pain all over the body in last month	1.5	1.7	3.0	-0.8	-1.2	-1.4	-1.7	-1.4	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	3.8	1.0	1.4	1.8	-0.7	1.8	-2.0
Handedness (chirality/laterality): Left-handed	1.5	1.8	5.8	-1.1	2.4	1.0	1.5	0.5	-1.3
Loneliness, isolation	1.5	2.1	9.5	-2.0	-0.2	-0.6	-3.1	-0.9	0.2
Eye problems/disorders: Glaucoma	1.5	1.8	4.8	2.2	0.8	0.9	2.0	1.0	-1.0
Diastolic blood pressure, automated reading	1.5	4.8	13.7	3.7	0.1	2.3	1.6	2.9	-1.8
HbA1C	1.4	1.5	4.4	2.1	0.7	1.4	-0.3	1.8	-0.9
Neuroticism score	1.4	2.8	12.0	-1.8	-1.1	-1.3	-3.5	-1.2	0.4
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	4.2	-0.6	-0.9	-1.7	-1.8	-2.1	0.8
Mouth/teeth dental problems: Loose teeth	1.4	1.6	4.4	0.9	2.1	1.2	-0.5	1.2	-1.8
Financial situation satisfaction	1.4	1.7	3.2	0.9	1.8	1.6	0.9	1.4	-1.6
Neuroticism (Nagel 2018)	1.3	3.0	8.5	-0.6	-2.0	-2.0	-2.9	-1.5	1.3
Alzheimer’s Disease (including proxy)	1.3	1.9	3.4	-1.2	-1.8	-1.9	-0.8	-1.8	1.0
Waist Hip Ratio (WHR)	1.3	5.9	11.7	-3.1	-2.0	-2.7	-1.1	-3.4	2.8
Fed-up feelings	1.3	2.4	10.4	-0.3	-1.7	-1.3	-3.2	-0.8	1.1
Financial difficulties in last 2 years	1.3	1.7	5.0	2.2	1.8	1.4	-0.3	1.2	-0.6
Impedance of arm (right)	1.3	6.1	20.9	-4.6	-1.6	-2.0	0.1	-2.6	2.9
Impedance of arm (left)	1.3	6.2	20.7	-4.5	-1.9	-2.1	-0.3	-2.6	2.8
Peak expiratory flow (PEF)	1.3	3.0	7.7	2.2	0.4	1.7	2.8	1.8	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	4.6	-2.1	-0.6	-1.5	0.0	-1.0	1.7
Commuting to job workplace: Walk	1.3	1.4	5.6	0.0	1.2	1.4	2.4	0.8	0.2
Osteoporosis (self-reported)	1.3	1.6	4.2	0.3	1.4	2.0	1.4	1.7	-0.3
Smoking status: Current	1.3	2.0	6.8	-1.6	-0.7	-1.1	-2.6	-1.5	1.1
Tinnitus: Yes, now most or all of the time	1.3	1.5	4.9	-1.1	-1.7	-0.9	-0.1	-1.0	2.2
Pain type(s) experienced in last month: Hip pain	1.3	1.6	7.7	-0.8	2.8	1.1	-0.9	0.7	-0.7
Mean Putamen Volume	1.2	1.3	5.0	2.2	0.8	0.9	1.0	0.9	-1.0
Blood Red Count	1.2	11.5	30.2	-5.5	-1.5	-3.6	-1.9	-4.2	3.7
Current tobacco smoking	1.2	2.0	9.0	-1.2	-0.4	-0.9	-3.0	-1.2	0.8
High blood pressure (siblings)	1.2	1.8	7.8	2.8	0.3	1.0	0.5	1.5	-1.0
Migraine (self-reported)	1.2	1.5	4.3	2.1	0.2	1.2	0.3	1.3	-1.8
Medication: Allopurinol	1.2	1.6	2.7	1.6	1.6	1.0	1.6	0.9	-1.2
Long-standing illness, disability or infirmity	1.2	1.8	6.4	2.5	0.2	1.4	0.1	1.6	-1.3
Illnesses of father: High blood pressure	1.2	1.5	2.9	1.1	0.6	1.6	1.2	1.5	-1.7
Commuting to job workplace: Cycle	1.2	1.5	4.4	1.0	2.1	1.1	1.6	0.6	-1.0
Heart attack/myocardial infarction (self-reported)	1.2	1.6	6.5	2.6	0.7	1.2	0.4	1.5	-0.5
Depressed Affect (Nagel 2018)	1.1	2.2	9.5	0.1	-1.5	-1.4	-3.1	-0.9	1.1
Average weekly fortified wine intake	1.1	1.3	3.9	-2.0	0.0	-1.3	0.2	-1.6	0.9
Taking other prescription medications	1.1	1.7	3.2	1.7	1.1	1.8	-0.4	1.7	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	2.9	-0.3	1.5	1.7	-1.4	1.7	-1.2
Medication: Atorvastatin	1.1	1.4	7.7	2.8	-0.8	-0.2	0.7	0.7	-0.4
Pack years of smoking	1.1	1.6	3.3	1.8	1.8	1.1	0.3	1.3	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	4.2	-1.6	-0.8	-2.1	-1.4	-1.9	1.8
Number of incorrect matches in round	1.0	1.7	4.9	-1.1	2.2	1.9	0.7	1.0	-0.6
Medication: Ramipril	1.0	1.2	3.1	1.0	-1.8	-0.9	-1.8	-0.4	0.7
Mouth/teeth dental problems: Dentures	1.0	1.8	4.1	2.0	1.0	1.1	1.3	1.4	-1.5
Hair/balding pattern: Pattern 4	1.0	2.3	6.4	-1.0	-1.3	-2.5	0.3	-2.4	1.2
Medication: Amlodipine	1.0	1.5	3.7	1.2	0.3	1.7	1.1	1.9	-0.8
Medication: Ibuprofen	1.0	1.1	3.0	0.3	-1.0	-1.6	-1.1	-1.7	0.5
Medication: Aspirin	1.0	1.3	4.7	0.7	-1.6	-1.0	-2.2	-0.5	0.8
Mood swings	1.0	1.7	5.4	-1.4	-0.6	-1.6	-2.3	-1.4	0.2
Vascular/heart problems diagnosed by doctor	1.0	2.7	11.0	-3.3	0.6	-1.3	0.2	-2.1	1.4
Average weekly spirits intake	0.9	1.1	3.4	-1.0	1.8	0.6	-0.7	0.2	-1.5
High blood pressure	0.9	2.5	8.2	2.9	-0.8	1.3	0.2	2.0	-1.8
Hearing difficulty/problems with background noise	0.9	1.4	4.6	-1.6	2.2	-0.4	1.0	-1.1	0.5
Heart attack	0.9	1.2	4.4	2.1	0.8	1.1	-0.1	1.3	-0.4
Qualifications: A levels/AS levels or equivalent	0.9	1.9	3.3	1.5	-0.4	1.7	1.7	1.8	-1.5
Lung cancer (father)	0.9	1.0	4.4	-0.5	1.2	-0.2	2.1	-0.7	0.8
Medication for pain relief, constipation, heartburn	0.9	1.6	5.1	0.6	1.4	1.2	2.3	1.1	-1.0
Medication: Blood pressure	0.9	1.6	5.6	2.4	-2.0	0.3	-0.4	1.1	-0.5
Suffer from ‘nerves’	0.9	1.4	2.8	-0.5	-1.4	-1.5	-1.7	-1.5	0.7
High cholesterol (Self-reported)	0.9	1.5	3.0	1.4	-1.3	-1.7	-1.7	-1.0	0.6
Leg fat percentage (left)	0.9	3.1	16.8	0.5	-2.0	-0.8	-4.1	0.1	-0.6
Number of operations (self-reported)	0.9	1.3	3.2	1.6	-0.0	1.3	-0.4	1.8	-1.3
Ever depressed for a whole week	0.9	1.2	2.0	0.9	1.4	1.1	0.9	1.3	-1.3
Crohns Disease (2017)	0.8	1.7	3.7	1.1	1.6	1.4	1.1	1.2	-1.9
Angina	0.8	1.0	5.9	2.4	-0.5	-0.1	-0.6	0.6	0.5
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	4.9	-2.2	1.7	0.5	1.0	-0.5	-0.1
Birth weight	0.8	1.8	7.2	1.7	-0.4	0.6	2.7	1.2	-0.5
Leg fat percentage (right)	0.8	3.0	16.3	0.1	-1.9	-0.8	-4.0	0.0	-0.7
Angina (self-reported)	0.8	1.1	6.6	2.6	-0.2	0.0	-0.6	0.8	0.3
Alcohol intake frequency.	0.8	1.8	4.6	-1.2	-2.1	-0.6	-1.8	-1.0	1.3
Number of full sisters	0.8	1.0	4.0	-0.0	-2.0	-0.7	-1.3	-0.1	0.7
Commuting to job workplace: Car/motor vehicle	0.8	0.9	4.1	0.2	-1.2	0.1	-2.0	0.5	0.5
Medication: Aspirin	0.8	1.1	4.1	0.4	-1.2	-0.9	-2.0	-0.5	1.0
Unable to work because of sickness or disability	0.8	1.1	2.5	-0.6	0.4	1.5	-0.6	1.6	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.2	0.4	1.2	1.4	1.2	1.5	0.4
Neuroticism	0.7	1.6	9.4	-0.2	-1.2	-0.6	-3.1	-0.3	0.1
Medication: Co-codamol	0.7	0.8	2.2	0.6	1.5	1.0	-0.4	1.0	-1.0
Trunk fat percentage	0.7	3.0	6.7	2.6	-1.3	1.3	-1.6	2.2	-1.8
Exposure to tobacco smoke outside home	0.7	1.0	2.9	-0.7	-0.9	-1.2	-1.7	-1.1	0.2
Number of children fathered	0.7	0.8	2.0	0.1	-0.6	-1.4	1.4	-1.1	-0.1
Eye problems/disorders: None of the above	0.7	0.8	2.4	-0.9	1.5	1.0	-0.2	0.4	-1.1
Smoking status: Previous	0.7	1.0	1.7	1.1	1.1	1.1	1.0	1.3	-0.9
Diabetes diagnosed by doctor	0.7	1.1	2.5	1.4	-1.3	-1.6	-1.1	-0.6	0.4
Number of self-reported non-cancer illnesses	0.7	1.3	6.4	2.5	-0.5	0.3	0.2	1.1	-0.8
Supplements: Calcium	0.7	0.8	2.3	0.4	0.9	1.0	0.4	1.1	-1.5
Worry (Nagel 2018)	0.6	1.2	3.0	-1.1	-1.0	-1.2	-1.7	-1.1	0.9
Age at First Birth	0.6	0.8	1.8	-1.0	-0.6	-1.3	0.7	-1.1	1.0
Schizophrenia (2014)	0.6	1.2	3.8	1.9	1.1	0.9	0.7	1.4	-0.5
BMI	0.6	3.4	11.2	3.3	-0.7	1.1	-2.2	1.8	-1.7
Systolic Blood Pressure	0.6	2.8	11.4	3.4	-0.2	0.7	2.2	1.5	-0.8
Hypothyroidism (self reported)	0.6	1.5	4.6	2.1	-1.6	-1.3	-0.1	-0.9	0.9
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	5.1	0.1	-0.5	0.4	-2.3	0.2	-0.6
Ever used hormone-replacement therapy (HRT)	0.6	0.8	3.3	1.8	0.4	0.3	1.3	0.7	-0.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.6	1.3	-0.1	0.8	0.1	0.9	-1.3
Medication: Levothyroxine sodium	0.6	1.1	2.8	1.7	-0.8	-0.8	-1.6	-0.4	0.6
Body mass index (BMI)	0.6	2.6	6.5	2.6	-0.5	1.0	-2.3	1.6	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	4.6	-1.2	0.7	0.0	-2.2	0.0	-0.5
Medication: Cholesterol lowering	0.6	0.9	2.7	1.6	-1.4	-0.8	-0.9	-0.1	0.5
Medication: Lansoprazole	0.6	0.7	1.8	-0.5	-1.4	-1.0	-1.2	-0.6	0.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	3.7	1.9	-1.1	-1.0	-1.1	-0.6	0.4
Body fat percentage	0.6	2.3	7.2	1.6	-1.7	0.5	-2.7	1.4	-1.3
Hypertension (Self-reported)	0.6	1.8	5.2	2.3	-1.0	1.1	-0.1	1.7	-1.5
Friendships satisfaction	0.6	0.8	2.4	0.5	-1.6	-0.8	-1.4	-0.4	0.0
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.4	-0.4	-1.3	-1.1	-0.6	-1.1	1.5
Breast cancer (self-reported)	0.6	0.7	2.8	-1.7	-0.8	-0.5	-0.4	-1.0	0.4
Guilty feelings	0.6	0.9	2.1	-0.1	-1.1	-1.5	-1.3	-1.1	-0.4
Commuting to job workplace: Public transport	0.6	0.7	3.0	-0.8	0.5	0.5	1.7	0.2	-1.0
Intelligence (Savage-Jansen 2018)	0.5	1.4	6.7	2.6	-1.3	-0.3	-0.2	0.5	-1.2
Irritable Bowel Disease (IBD)	0.5	1.3	2.6	1.6	0.9	0.9	1.2	1.0	-1.6
Body Mass Index (BMI) (2010)	0.5	0.7	2.2	1.5	0.6	1.0	-0.3	0.8	-0.7
Coronary Artery Disease (CAD)	0.5	0.6	1.5	-1.1	-1.2	-0.5	-1.0	-0.5	-0.5
Ulcerative Colitis	0.5	0.7	2.5	0.8	0.6	0.3	1.6	0.6	-1.0
Cardiovascular Disease	0.5	1.8	5.8	2.4	-0.6	0.9	-0.4	1.8	-1.5
Lung FEV1/FVC ratio	0.5	2.8	6.6	0.2	-2.4	-2.6	0.2	-2.3	1.4
Sensitivity / hurt feelings	0.5	0.9	3.4	1.0	0.1	0.6	-0.8	1.0	-1.9
Systolic blood pressure, automated reading	0.5	1.3	7.7	2.8	-0.7	-0.6	0.9	0.2	0.2
Townsend deprivation index at recruitment	0.5	0.6	1.3	0.7	0.6	1.2	-0.9	1.0	-0.6
Age when periods started (menarche)	0.5	1.3	5.8	1.1	-2.4	-0.5	1.0	0.2	0.9
Illnesses of siblings	0.5	0.6	2.9	-1.7	0.0	-0.5	0.5	-1.1	0.3
Happiness	0.5	0.6	1.5	-0.5	-1.0	-1.0	-1.2	-0.9	0.3
Birth weight of first child	0.5	0.9	2.8	-0.9	-1.7	-0.9	-1.1	-0.6	0.5
Loud music exposure frequency	0.5	0.6	2.8	-0.2	1.0	0.3	-1.7	0.3	-0.1
Number of full brothers	0.5	0.7	2.8	0.2	1.2	0.4	1.7	0.3	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.4	0.8	-0.0	1.1	1.1	1.2	-0.2
Age at first live birth	0.5	0.9	2.6	-1.1	-1.6	-1.0	-0.0	-0.6	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.3	-1.1	-0.4	-1.1	-0.6	-1.0	0.1
Had major operations	0.5	0.6	2.2	1.5	-0.2	0.6	-0.0	0.9	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.4	-1.5	-0.3	-0.7	0.4	-1.0	0.2
Miserableness	0.5	0.9	2.8	0.1	0.6	0.8	-1.7	0.9	-1.1
Medication: Bendroflumethiazide	0.5	0.8	4.2	1.1	-2.0	-0.3	0.2	0.4	-0.3
Cholesterol lowering medication	0.5	0.7	2.6	1.6	-0.3	-0.6	-0.7	-0.0	-1.1
Alcohol drinker status: Previous	0.5	0.5	2.3	1.5	-0.2	0.7	0.5	0.7	0.0
Schizophrenia (2018)	0.4	0.8	1.8	1.3	1.3	0.8	0.2	1.0	-0.7
Breast Cancer	0.4	1.0	3.9	1.2	-2.0	-0.8	-0.9	0.1	0.1
Ovarian Cancer	0.4	0.5	0.9	-0.9	0.9	-0.4	0.7	-0.3	1.0
Crohns Disease (2012)	0.4	0.6	1.7	-0.4	0.9	0.9	0.8	0.5	-1.3
HDL Cholesterol	0.4	0.7	3.5	0.1	-1.9	-0.6	-0.4	-0.3	0.9
Lung FVC	0.4	2.1	7.8	-1.5	0.2	2.8	0.6	2.1	-0.0
Chronotype (morning person)	0.4	1.0	3.0	-1.4	0.2	-0.8	1.7	-0.9	0.6
Number of treatments/medications taken	0.4	0.8	2.4	1.5	-1.1	-0.1	-1.1	0.2	1.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.7	0.7	0.2	0.4	1.3	0.8	-0.4
Medication: Metformin	0.4	0.5	1.7	0.8	0.9	-0.6	-1.3	-0.3	-0.4
Serious illness, injury or assault to yourself	0.4	0.4	1.4	1.2	-0.5	0.2	-0.6	0.5	-0.9
Stomach or abdominal pain in last month	0.4	0.6	1.1	-1.1	0.6	1.0	-0.1	0.9	-0.7
Had menopause	0.4	0.5	2.2	1.5	-0.1	-0.7	-0.1	-0.6	-0.3
Mouth/teeth dental problems	0.4	0.5	2.4	-1.5	0.6	-0.1	0.8	-0.5	0.3
Diabetes (self-reported)	0.4	0.7	1.9	1.4	-0.6	-1.2	-0.8	-0.4	-0.0
Arm fat percentage (right)	0.4	1.5	6.8	0.6	-1.7	0.1	-2.6	0.6	-0.6
Time employed in main current job	0.4	0.4	1.6	0.1	-0.7	0.2	0.9	0.3	1.3
Worrier / anxious feelings	0.4	0.7	1.5	0.4	-1.2	-1.2	-0.9	-0.7	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	4.4	0.2	-0.6	0.3	-2.1	0.5	0.2
Exposure to tobacco smoke at home	0.4	0.4	1.5	-1.2	0.4	-0.2	-0.8	-0.5	0.5
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.2	-1.1	0.2	-0.1	-0.3	-0.9	1.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.2	1.1	-0.0	0.5	0.8	0.9	-0.6
Medication: Omeprazole	0.4	0.5	0.8	0.1	0.8	0.8	0.9	0.8	0.9
Illnesses of father: Heart disease	0.4	0.6	2.4	-0.3	-0.9	-0.4	-1.5	-0.5	0.8
Arm fat percentage (left)	0.4	1.7	7.9	0.6	-1.7	0.1	-2.8	0.6	-0.7
Average weekly red wine intake	0.4	0.5	2.2	1.1	-0.1	-0.1	1.5	0.1	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	2.1	0.4	1.5	0.6	-0.7	0.5	0.1
Mineral and other dietary supplements	0.4	0.5	1.1	-0.2	-0.9	0.9	-1.1	0.9	-0.3
Illnesses of father: None of the above (group 1)	0.4	0.4	0.8	0.3	-0.7	-0.9	0.7	-0.9	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.2	-0.8	-1.5	-0.4	-0.2	-0.7	1.4
Hearing aid user	0.4	0.4	1.3	-0.6	-0.4	-0.0	1.1	-0.3	1.0
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	-0.2	-1.0	-0.7	-0.9	-0.7	0.5
Major Depression (MDD)	0.3	0.4	1.4	0.5	-0.8	-0.5	-1.2	-0.2	-0.2
Reaction Time	0.3	0.6	1.5	-1.1	0.7	0.7	1.2	0.6	-0.2
Neuroticism (2016)	0.3	0.5	2.7	-0.3	-0.6	-0.0	-1.6	-0.1	-0.3
Relative age of first facial hair	0.3	0.6	1.2	-0.8	0.8	1.1	-1.0	0.7	-0.2
Medication for hormone replacement therapy	0.3	0.4	1.4	0.5	1.2	0.7	0.5	0.4	-0.0
Relative age voice broke	0.3	0.4	0.6	-0.8	0.6	0.7	-0.1	0.7	-0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.8	0.6	-1.3	-0.4	0.1	0.1	0.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.4	-0.0	1.2	0.4	-0.5	0.2	-0.8
Allergy	0.3	0.8	2.0	-1.4	-0.8	0.1	-1.3	0.1	1.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.5	0.9	0.5	0.1	0.0	0.3	-1.2
Fluid intelligence score	0.3	0.5	2.3	0.4	-1.0	-0.2	-1.5	0.3	-0.2
Hair/balding pattern: Pattern 3	0.3	0.4	1.1	0.5	-0.8	-1.0	0.3	-0.7	0.6
Number of live births	0.3	0.5	1.4	-0.4	-0.7	-0.3	1.1	-0.1	1.2
Illnesses of mother	0.3	0.4	0.7	-0.8	0.7	-0.6	-0.1	-0.8	0.6
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.4	-0.4	1.2	-0.5	-0.1	-0.8	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.6	0.9	-0.9	0.4	0.1	0.6	-1.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.9	0.1	-0.7	0.2	-1.4	0.5	0.3
Neck or shoulder pain in last month	0.3	0.4	1.1	-0.9	-0.0	-0.8	-0.4	-1.0	0.4
Mean time to correctly identify matches	0.3	0.6	2.1	-1.4	0.4	-0.4	0.7	-0.5	1.0
Pulse rate, automated reading	0.3	1.1	2.0	1.2	0.9	1.2	1.3	1.4	-0.2
Overall health rating	0.3	0.7	1.3	1.0	0.7	0.6	-0.9	0.9	-1.1
Leg pain on walking	0.3	0.4	1.8	0.3	1.3	-0.4	0.3	-0.6	-0.3
Illnesses of siblings: Diabetes	0.3	0.4	1.6	1.3	-0.4	0.2	-0.7	0.5	0.2
Back pain experienced in last month	0.3	0.4	1.2	1.1	0.5	0.5	-0.1	0.7	-0.7
Medication: Blood pressure	0.3	0.5	1.8	1.3	-0.6	0.2	-1.1	0.2	-0.2
Medication: Lisinopril	0.3	0.4	1.9	1.4	-0.6	0.1	-0.2	0.6	0.2
Alcohol drinker status: Never	0.3	0.4	1.8	0.7	-1.3	0.1	-0.6	0.2	0.4
Risk taking	0.3	0.5	2.6	1.6	-0.5	-0.1	0.3	0.3	-0.6
Bipolar Disorder (2018)	0.2	0.3	1.5	-0.3	-1.2	-0.0	-0.4	0.2	0.6
Schizophrenia vs Biploar Disorder	0.2	0.3	1.3	1.1	0.2	-0.0	0.3	0.3	0.8
Alzheimer’s Disease (in father)	0.2	0.2	0.5	-0.7	0.1	-0.1	-0.7	-0.3	-0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.8	1.0	-1.4	-0.4	-0.8	-0.0	-0.5
Rheumatoid Arthritis	0.2	0.3	0.9	0.0	-1.0	-0.7	0.4	-0.7	0.0
Triglycerides	0.2	0.3	0.9	0.4	0.5	-0.4	-0.2	-0.7	1.0
Blood White Count	0.2	1.6	6.7	0.9	-0.9	-0.8	-2.6	-0.5	1.3
Hearing difficulty/problems: Yes	0.2	0.3	0.6	-0.5	0.8	-0.3	0.5	-0.7	0.4
Vitamin and mineral supplements	0.2	0.3	0.9	-0.9	-0.2	0.6	-0.4	0.4	-0.4
Diabetes (mother)	0.2	0.3	1.6	1.2	-0.3	-0.2	-0.2	0.1	0.1
Severe depression (siblings)	0.2	0.2	1.0	1.0	-0.6	-0.5	-0.1	-0.2	0.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	1.0	0.4	-0.0	-0.0	0.8	0.1	-1.0
Qualifications: CSEs or equivalent	0.2	0.3	1.3	-1.1	-0.6	-0.1	-0.2	-0.2	0.2
Multivitamins +/- minerals	0.2	0.2	1.1	0.0	1.1	-0.3	0.2	-0.4	0.4
Supplements: Glucosamine	0.2	0.2	0.9	0.2	0.3	-0.9	-0.3	-0.6	-0.2
Alcohol usually taken with meals	0.2	0.4	0.9	0.8	0.7	0.6	1.0	0.4	-0.4
Had other major operations	0.2	0.3	0.7	0.3	0.2	0.7	-0.4	0.7	-0.8
Medication: Simvastatin	0.2	0.3	0.7	0.8	-0.3	-0.5	-0.8	-0.3	-0.4
Alcohol intake versus 10 years previously	0.2	0.4	0.5	0.6	0.5	0.7	0.7	0.7	-0.7
Pulse wave Arterial Stiffness index	0.2	0.3	1.0	1.0	0.1	0.6	0.4	0.6	0.0
Tense / ‘highly strung’	0.2	0.3	1.1	-0.8	0.2	0.3	-1.0	0.0	0.1
Pulse wave reflection index	0.2	0.3	1.3	0.2	-0.4	0.0	-0.2	-0.5	1.2
Medication: Paracetamol	0.2	0.3	1.1	0.2	-0.7	0.2	-1.1	0.2	-0.2
Wheeze or whistling in the chest in last year	0.2	0.4	0.9	0.8	-0.6	-0.8	-0.9	-0.3	0.3
Qualifications: College or University degree	0.2	0.7	2.2	1.2	-0.3	0.1	1.5	0.9	-0.0
Age at last live birth	0.2	0.3	1.0	0.2	-0.4	0.5	0.9	1.0	0.0
Family relationship satisfaction	0.2	0.2	0.5	0.3	-0.4	-0.5	0.4	-0.6	0.7
Supplements: Vitamin C	0.2	0.2	0.8	0.3	-0.6	-0.2	0.9	0.1	0.0
Qualifications: nursing, teaching	0.2	0.3	0.8	0.1	0.7	0.9	-0.2	0.8	-0.6
Medication for cholesterol	0.2	0.3	1.1	-0.9	0.4	0.1	1.0	0.0	0.1
Asthma (self-reported)	0.2	0.3	1.0	0.3	0.9	0.4	1.0	0.2	-0.5
Medication: Gliclazide	0.2	0.2	0.6	-0.1	0.3	-0.8	0.6	-0.5	0.3
Ever taken oral contraceptive pill	0.2	0.2	0.6	0.7	0.0	0.0	0.8	0.5	0.2
Mother’s age at death	0.2	0.3	0.9	-1.0	0.6	-0.1	0.7	0.0	-0.3
Fractured/broken bones in last 5 years	0.2	0.3	1.0	1.0	0.0	-0.6	-0.4	-0.5	0.6
Heart disease (siblings)	0.2	0.3	0.6	-0.5	0.2	-0.8	-0.6	-0.7	0.4
Bipolar Disorder or Schizophrenia	0.1	0.3	0.9	0.9	0.3	0.6	-0.1	0.9	-0.2
Ulcerative Colitis (UC)	0.1	0.2	0.7	0.9	-0.3	-0.1	0.7	0.1	-0.5
Prostate Cancer	0.1	0.2	0.8	0.9	-0.5	0.2	0.1	0.4	0.5
Bipolar Disorder (2011)	0.1	0.1	0.4	0.2	-0.4	-0.4	-0.6	-0.5	0.1
LDL Cholesterol	0.1	0.2	0.7	-0.2	0.3	0.4	0.4	0.3	0.8
Blood Eosinophil Count	0.1	0.5	2.1	-0.7	-0.4	0.6	-1.5	0.5	0.5
Smoking Status	0.1	0.3	2.3	0.0	0.2	0.0	-1.5	-0.1	-0.1
Respiratory disease	0.1	0.2	0.4	0.4	-0.1	-0.5	0.7	-0.6	0.2
Diabetes (father)	0.1	0.1	0.3	0.1	0.2	-0.3	0.2	-0.1	0.5
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.3	0.4	-0.4	0.4	-0.6	-0.7
Medication: Atenolol	0.1	0.1	0.4	0.4	0.4	-0.3	-0.6	-0.4	-0.2
Past tobacco smoking	0.1	0.2	0.4	-0.2	-0.7	-0.5	-0.1	-0.6	0.1
Qualifications: None of the above	0.1	0.3	0.6	0.4	0.8	0.5	-0.7	0.6	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.6	-0.2	-0.2	0.1	-0.8	-0.4	0.3
Asthma	0.1	0.2	0.9	0.2	0.8	0.3	0.9	0.1	-0.0
Length of working week for main job	0.1	0.1	0.2	0.5	-0.3	-0.2	-0.1	-0.2	0.4
Breastfed as a baby	0.1	0.2	0.6	-0.3	0.8	0.0	0.1	-0.2	-0.6
Gout (self-reported)	0.1	0.1	0.6	0.3	0.8	0.2	0.3	-0.0	-0.1
Pulse wave peak to peak time	0.1	0.1	0.3	-0.1	0.2	0.1	0.2	0.3	-0.6
Health satisfaction	0.1	0.2	0.9	0.9	0.4	-0.3	0.2	0.1	-0.1
Shortness of breath walking on level ground	0.1	0.2	0.6	0.4	0.8	-0.2	-0.1	-0.2	-0.5
Emphysema/chronic bronchitis	0.1	0.1	0.3	-0.3	0.2	-0.6	-0.2	-0.6	-0.1
Medication: Seretide 50 evohaler	0.1	0.1	0.6	-0.8	-0.1	-0.1	-0.3	-0.4	0.3
Heart disease (mother)	0.1	0.1	0.2	-0.1	-0.0	0.4	0.3	0.4	0.4
Chest pain or discomfort	0.1	0.2	0.5	0.7	0.6	0.4	0.1	0.6	0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.4	-0.2	-0.4	0.3	0.1	0.2
Ever had bowel cancer screening	0.1	0.1	0.3	-0.0	-0.2	-0.5	-0.1	-0.4	0.1
Medication: Paracetamol	0.1	0.2	0.5	0.7	-0.7	-0.6	-0.2	-0.4	0.1
Ever smoked	0.1	0.2	0.5	-0.6	0.7	0.3	-0.3	0.2	-0.2
Average weekly beer plus cider intake	0.1	0.2	0.6	0.8	-0.0	0.3	-0.3	0.6	0.4
Pain experienced in last month	0.1	0.1	0.4	0.2	-0.2	0.3	0.0	0.6	-0.6
Allergy or Eczema	0.0	0.1	0.3	0.6	0.4	-0.1	0.1	-0.3	-0.5

Hub : Genes

E2F1

Models

Trait associations