TWAS hub - CBFA2T2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1570	0.0580	1.9e-03	0.002	NA	0.011	NA	0.003	2.0e-01	NA	4.0e-02	NA	1.6e-01
2	GTEx	Artery Aorta	0.2260	0.0630	2.2e-06	0.111	NA	0.178	NA	0.165	1.1e-06	NA	4.5e-10	NA	2.1e-09
3	GTEx	Brain Cerebellum	0.2710	0.0800	3.2e-05	0.072	NA	0.101	NA	0.096	3.6e-03	NA	6.7e-04	NA	9.1e-04
4	GTEx	Cells Transformed fibroblasts	0.0790	0.0350	3.8e-03	0.066	NA	0.033	NA	0.046	1.1e-05	NA	1.5e-03	NA	2.3e-04
5	GTEx	Muscle Skeletal	0.0528	0.0240	2.7e-03	0.011	NA	0.012	NA	0.012	2.8e-02	NA	2.0e-02	NA	2.3e-02
6	GTEx	Pituitary	0.3620	0.1310	9.1e-03	-0.011	NA	0.004	NA	-0.011	8.1e-01	NA	2.6e-01	NA	8.5e-01
7	GTEx	Testis	0.1040	0.0470	5.4e-03	0.070	NA	0.068	NA	0.065	5.0e-04	NA	6.1e-04	NA	7.7e-04
8	GTEx	Thyroid	0.1110	0.0400	1.0e-04	0.046	NA	0.059	NA	0.038	1.8e-04	NA	2.6e-05	NA	6.5e-04
9	ROSMAP	Brain Pre-frontal Cortex	0.0791	0.0246	1.0e-07	0.082	0.058	0.070	0.069	0.079	1.1e-10	5.3e-08	2.6e-09	3.3e-09	2.3e-10
10	TCGA	Colon Adenocarcinoma	0.1250	0.0990	6.0e-03	0.036	0.011	0.016	NA	0.026	3.5e-03	6.9e-02	3.8e-02	NA	1.1e-02
11	TCGA	Brain Lower Grade Glioma	0.0179	0.0130	1.0e-02	0.008	0.011	0.001	NA	0.005	4.0e-02	1.8e-02	2.5e-01	NA	7.7e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Tanning	56.1	684.7	1874.9	-10.4	26.4	29.9	19.3	19.6	43.3	25.7	17.5	21.0	28.3	31.5
Hair Pigment	27.1	771.9	2188.2	10.7	-26.5	-31.2	-18.8	-23.0	-46.8	-28.0	-16.8	-20.6	-31.3	-33.9
Trunk fat-free mass	14.9	85.6	134.6	7.5	11.1	8.7	6.7	8.7	8.5	11.6	9.4	6.8	10.9	10.3
Trunk predicted mass	14.8	84.5	134.6	7.5	11.1	8.6	6.6	8.7	8.5	11.6	9.3	6.7	10.8	10.2
Height	14.6	281.2	453.7	14.8	19.2	14.9	11.5	17.3	11.2	21.1	17.0	12.1	21.3	19.8
Whole body fat-free mass	14.2	81.1	130.0	7.4	10.8	8.3	6.2	8.8	8.0	11.4	9.2	6.4	10.7	10.0
Whole body water mass	14.2	81.1	132.2	7.4	10.9	8.3	6.2	8.9	8.0	11.5	9.2	6.4	10.6	10.0
Forced expiratory volume in 1-second (FEV1), predicted	13.5	28.0	45.4	3.3	5.7	4.8	3.8	5.9	4.5	6.6	5.9	3.6	6.7	6.0
Basal metabolic rate	13.1	72.6	121.0	7.0	10.1	7.8	5.7	8.7	7.5	11.0	8.6	5.8	10.2	9.4
Standing height	13.0	129.4	212.4	10.0	12.8	10.0	7.8	11.7	8.5	14.6	11.1	7.9	14.5	13.4
Arm fat-free mass (right)	12.9	66.0	106.1	5.9	9.6	7.4	5.6	8.7	7.5	10.3	8.2	5.6	9.8	9.1
Arm predicted mass (right)	12.9	65.9	106.9	5.9	9.6	7.3	5.7	8.5	7.4	10.3	8.2	5.6	9.8	9.1
Leg fat-free mass (right)	12.8	68.3	114.5	6.9	9.9	7.5	5.6	8.2	6.8	10.7	8.6	5.9	9.8	9.1
Leg predicted mass (right)	12.7	68.0	112.4	6.9	9.9	7.6	5.5	8.2	6.8	10.6	8.6	5.8	9.8	9.1
Leg predicted mass (left)	12.3	65.3	108.2	7.2	9.8	7.5	5.4	8.1	6.6	10.4	8.3	5.7	9.5	8.8
Arm predicted mass (left)	12.3	62.5	102.0	5.9	9.4	7.3	5.4	8.1	7.6	10.1	7.8	5.5	9.3	8.8
Leg fat-free mass (left)	12.2	64.8	108.2	7.1	9.7	7.5	5.4	8.1	6.5	10.4	8.3	5.6	9.5	8.8
Arm fat-free mass (left)	11.8	60.0	100.1	6.1	9.2	7.1	5.3	8.2	7.0	10.0	7.7	5.2	9.2	8.6
Sitting height	11.3	80.0	132.2	7.6	10.0	8.1	6.0	9.4	8.4	11.5	7.8	5.8	11.2	10.4
Comparative height size at age 10	10.0	55.2	96.2	8.0	7.8	6.3	5.3	7.3	4.2	9.0	7.2	5.6	9.8	9.0
Weight	8.2	40.5	72.1	5.2	7.2	5.7	3.6	7.6	5.2	8.5	6.2	3.6	8.0	6.9
Hip circumference	6.3	27.2	50.7	4.3	5.5	4.3	2.4	6.9	4.0	7.1	4.5	2.6	7.0	5.8
Forced vital capacity (FVC), Best measure	6.2	22.6	41.0	4.6	4.9	3.8	3.4	5.1	1.6	6.2	5.3	3.1	6.4	5.6
Chronic bronchitis/emphysema (father)	5.9	6.9	13.2	1.6	2.5	2.1	2.6	2.3	0.8	3.1	3.6	2.5	3.2	3.3
Maternal smoking around birth	5.4	7.9	13.7	2.9	3.7	3.3	3.3	1.0	3.2	3.0	2.6	2.9	1.7	2.2
Forced vital capacity (FVC)	5.2	20.1	38.0	4.7	4.5	3.2	2.9	4.9	1.3	6.1	4.8	2.6	6.2	5.3
Heel T-Score	4.5	35.8	88.5	-2.3	-5.6	-4.0	-2.5	-8.0	-2.1	-8.2	-5.7	-3.7	-9.4	-8.0
Eye problems/disorders: Cataract	4.3	4.9	14.2	-3.8	-3.0	-2.3	-2.3	-0.4	-0.9	-1.8	-2.3	-2.5	-1.3	-1.8
Primary Biliary Cirrhosis	3.9	5.6	9.4	1.9	2.1	2.9	1.3	2.6	2.1	2.8	1.9	1.7	3.1	2.8
Wears glasses or contact lenses	3.6	4.2	8.3	-1.0	-2.6	-1.5	-1.2	-2.5	-1.3	-2.9	-2.6	-0.9	-2.4	-2.0
Age started oral contraceptive pill	3.5	4.4	7.5	-0.5	-1.8	-2.3	-1.6	-2.4	-2.7	-2.1	-2.1	-1.6	-2.5	-2.3
Forced expiratory volume in 1-second (FEV1), Best measure	3.4	10.7	21.2	4.6	3.8	2.1	1.8	3.6	0.4	4.6	3.4	1.5	4.1	3.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.4	4.0	6.7	0.3	2.0	2.5	1.8	1.2	2.6	2.4	1.9	2.0	2.1	2.2
Type 2 Diabetes (T2D) (2018)	3.3	6.1	23.6	-4.9	-2.0	-1.2	-2.5	-0.7	3.1	-1.8	-3.0	-2.3	-1.4	-1.5
Trunk fat mass	3.2	13.6	34.8	3.1	3.4	2.8	1.1	5.9	2.5	5.1	3.0	1.1	5.2	3.9
Forced expiratory volume in 1-second (FEV1)	2.8	9.3	19.7	4.4	3.2	1.5	1.4	3.5	-0.0	4.4	3.1	1.0	4.0	3.2
Supplements: Fish oil (including cod liver oil)	2.8	3.6	15.2	-1.1	-0.7	-1.3	-0.8	-3.9	-0.6	-1.5	-2.2	-0.9	-2.8	-2.2
Impedance of whole body	2.8	14.1	27.6	-2.5	-5.3	-4.0	-3.0	-2.3	-4.2	-4.4	-4.2	-3.2	-3.4	-3.7
Supplements: Zinc	2.7	2.9	5.3	-0.0	1.9	2.0	1.4	0.9	2.3	1.6	1.5	2.2	1.6	2.0
Headache pain in last month	2.7	4.6	9.0	1.6	2.3	2.4	1.2	3.0	1.3	2.3	1.4	1.6	2.8	2.7
Alzheimer’s Disease (in mother)	2.6	3.0	5.4	-0.4	-1.2	-2.2	-1.6	-0.7	-1.8	-1.5	-2.1	-2.0	-2.0	-2.3
Fasting Glucose	2.6	3.1	8.3	-1.5	-1.5	-0.7	-1.5	-2.9	0.9	-1.8	-1.8	-1.4	-2.2	-2.3
Impedance of leg (left)	2.6	12.6	24.2	-3.3	-4.9	-3.7	-2.8	-2.0	-3.0	-4.3	-4.1	-3.2	-3.4	-3.5
Whole body fat mass	2.6	11.0	29.1	2.8	3.2	2.6	1.0	5.4	2.3	4.6	2.7	0.9	4.5	3.3
Pain type(s) experienced in last month: Hip pain	2.6	3.3	8.5	0.4	1.8	2.2	2.9	-0.5	1.2	1.2	2.5	2.8	0.6	1.2
Prospective memory result	2.5	3.1	5.6	1.4	2.4	2.3	2.2	-0.2	1.1	1.7	2.3	2.2	0.6	1.3
Myopia	2.5	3.6	7.0	0.0	1.8	1.8	1.6	1.6	2.6	2.0	1.8	1.8	2.1	2.3
Noisy workplace	2.4	3.0	7.6	2.4	1.4	1.9	2.3	-0.8	-0.6	1.0	2.4	2.8	0.6	1.0
Depression (self-reported)	2.4	2.9	6.3	-0.2	2.5	1.8	1.3	1.1	2.5	2.5	0.8	1.4	1.4	1.5
Comparative body size at age 10	2.4	6.7	11.2	1.9	3.3	2.7	2.8	1.6	2.1	3.1	3.3	2.4	2.2	2.4
Financial situation satisfaction	2.4	3.0	4.9	1.6	1.9	2.0	1.7	0.7	1.8	1.8	2.0	2.2	1.4	1.7
Lupus	2.3	3.5	7.0	0.8	2.6	2.3	1.3	0.9	2.3	2.0	1.3	1.9	2.0	2.2
Impedance of leg (right)	2.3	11.3	20.8	-2.4	-4.6	-3.3	-2.5	-2.1	-3.0	-4.1	-4.1	-3.0	-3.4	-3.4
Leg fat mass (left)	2.3	9.0	24.3	2.3	3.2	2.5	1.0	4.9	2.4	4.0	2.5	0.9	3.8	2.9
Blood Platelet Count	2.2	25.2	45.6	-4.4	-6.8	-3.6	-4.3	-4.6	-0.9	-6.3	-5.5	-4.5	-6.0	-5.7
Waist circumference	2.2	8.1	15.7	1.6	2.7	2.8	1.2	4.0	2.9	3.7	2.9	1.3	3.7	2.9
Arm fat mass (right)	2.2	8.9	20.2	2.9	3.2	2.4	0.8	4.5	2.5	4.3	2.6	0.8	3.7	2.7
Leg fat mass (right)	2.2	8.5	22.7	2.4	3.2	2.6	0.9	4.8	2.4	3.9	2.3	0.9	3.6	2.8
Handedness (chirality/laterality): Left-handed	2.2	2.7	6.6	2.3	1.5	1.6	2.6	-0.6	1.5	1.3	1.7	2.2	0.6	0.9
Average weekly champagne plus white wine intake	2.2	3.0	6.9	0.9	2.0	2.5	2.4	0.5	1.0	0.9	1.4	2.6	1.4	2.0
Financial difficulties in last 2 years	2.1	2.9	5.6	-0.1	1.9	1.8	2.4	0.8	2.1	1.2	2.0	2.1	1.2	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	5.7	1.9	1.6	1.6	1.1	2.4	1.9	1.8	1.2	1.1	1.8	1.5
Commuting to job workplace: Cycle	2.1	2.5	4.8	1.6	1.9	2.2	2.1	-0.2	1.5	1.4	1.2	2.1	0.6	1.3
Impedance of arm (left)	2.0	9.1	18.1	-1.1	-4.2	-3.3	-2.5	-2.0	-4.2	-3.1	-3.4	-2.5	-2.4	-2.9
Glaucoma (self-reported)	2.0	2.4	3.9	0.3	1.8	1.6	1.0	1.6	2.0	1.8	1.5	1.3	1.7	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	5.1	-1.6	-1.9	-2.3	-0.8	-0.4	-2.2	-0.9	-1.8	-1.2	-1.1	-1.2
Arm fat mass (left)	2.0	8.4	20.3	2.6	3.0	2.1	0.7	4.5	2.3	4.3	2.5	0.7	3.7	2.7
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	7.3	0.9	2.0	1.3	0.5	2.7	1.1	2.2	1.1	0.6	2.0	1.7
Depression (Nagel 2018)	1.9	2.9	7.1	-0.8	-0.6	-2.1	-2.1	-1.2	-0.8	-0.4	-1.7	-2.2	-2.4	-2.7
Type 2 Diabetes (T2D) (2012)	1.9	2.2	4.1	-1.3	-1.5	-0.9	-1.9	-0.6	-0.1	-2.0	-1.8	-1.3	-1.8	-1.8
Pack years adult smoking proportion	1.9	2.9	4.5	0.1	1.7	2.0	2.1	1.0	1.7	2.1	2.1	1.6	1.6	1.7
Mouth/teeth dental problems: Loose teeth	1.9	2.2	6.4	0.1	1.5	2.2	1.8	0.1	2.5	1.3	0.9	1.7	1.0	1.4
Diabetes diagnosed by doctor	1.9	3.1	12.5	-3.5	-1.0	-0.6	-1.6	0.5	3.1	-0.7	-2.1	-1.5	-0.6	-0.7
Blood clot in the leg (DVT)	1.8	2.3	6.1	1.0	2.0	1.2	0.3	2.5	0.8	2.1	0.8	0.4	2.0	1.7
Worry too long after embarrassment	1.8	3.0	4.5	-0.2	-1.5	-2.0	-2.1	-0.7	-1.7	-2.1	-1.7	-1.9	-1.8	-2.1
Medication: Allopurinol	1.8	2.4	4.8	2.2	1.9	2.1	1.3	-0.0	1.7	1.3	1.8	1.5	0.8	1.1
Illnesses of father: High blood pressure	1.8	2.2	8.4	1.5	1.3	0.9	1.3	1.6	-0.0	1.6	2.9	1.1	1.3	1.3
Basal cell carcinoma (self-reported)	1.8	2.1	8.6	0.6	-1.1	-0.9	-0.7	-1.4	-2.9	-2.0	-0.0	-0.4	-1.6	-1.7
High blood pressure (mother)	1.7	2.4	6.2	-0.0	1.0	2.1	1.3	1.8	2.5	1.2	1.2	0.9	1.6	1.7
Peak expiratory flow (PEF)	1.7	4.0	14.0	3.7	2.4	1.0	1.2	1.7	0.3	2.8	1.9	0.7	2.0	1.6
Knee pain experienced in last month	1.7	2.7	10.2	0.1	-0.6	-2.2	-1.2	-1.4	-3.2	-0.9	-0.7	-1.1	-1.8	-2.1
Taking other prescription medications	1.6	2.5	6.2	0.7	1.9	1.4	1.2	1.1	2.1	2.5	1.2	1.3	1.7	1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	7.9	-0.6	-2.1	-1.4	-1.0	-1.5	-1.3	-2.8	-1.9	-1.6	-2.8	-2.7
Impedance of arm (right)	1.6	7.5	15.2	-0.3	-3.5	-2.8	-2.2	-2.3	-3.9	-2.9	-3.1	-2.2	-2.4	-2.8
Irritability	1.6	2.6	7.4	-0.6	-1.5	-1.6	-1.4	-1.4	-2.7	-1.8	-1.6	-1.2	-1.6	-1.7
Osteoporosis (self-reported)	1.5	1.8	3.3	0.8	1.6	1.2	1.7	0.9	0.4	1.4	0.8	1.7	1.7	1.8
Neuroticism (Nagel 2018)	1.4	3.3	7.0	-0.5	-0.6	-2.2	-2.6	-0.4	-2.2	-0.9	-1.4	-2.6	-1.8	-2.4
Alzheimer’s Disease (including proxy)	1.4	2.1	3.8	-1.2	-1.0	-1.8	-1.6	-1.1	-0.4	-0.8	-1.8	-1.8	-1.7	-2.0
Ever had hysterectomy (womb removed)	1.4	1.6	3.4	1.2	1.5	1.3	1.2	0.7	0.6	1.8	1.2	1.2	1.2	1.4
Medication for hormone replacement therapy	1.4	1.6	3.0	-0.5	1.3	1.7	1.5	-0.7	1.5	1.2	1.6	1.5	0.5	1.0
Average weekly fortified wine intake	1.4	1.7	3.3	0.9	-0.9	-1.7	-0.6	-1.5	-1.3	-1.4	-0.7	-1.0	-1.8	-1.6
Falls in the last year	1.4	1.9	4.6	-0.8	-0.7	-1.0	-1.4	-0.8	1.1	-0.8	-1.7	-1.8	-1.8	-2.1
Medication: Cholesterol lowering	1.4	2.2	10.6	-3.3	-0.7	-0.6	-0.8	0.7	2.4	-1.2	-1.8	-1.1	0.2	-0.1
Eye problems/disorders: None of the above	1.4	1.6	5.0	2.2	1.4	1.3	1.8	-0.2	-0.7	0.3	1.6	1.6	0.3	0.7
Tinnitus: Yes, now most or all of the time	1.4	1.7	4.8	-1.3	-2.2	-0.9	-1.3	-1.0	-0.3	-1.9	-1.6	-1.0	-0.5	-0.8
Unable to work because of sickness or disability	1.4	1.8	5.6	2.4	1.1	0.8	-0.4	1.6	0.7	2.3	0.8	0.1	1.5	1.0
Pack years of smoking	1.4	2.1	3.9	-0.0	1.2	2.0	2.0	0.5	1.1	1.8	1.7	1.5	1.4	1.5
Average weekly spirits intake	1.3	1.6	5.1	0.8	1.3	1.8	1.6	-0.5	1.5	0.6	0.9	2.3	0.2	0.8
Hand grip strength (right)	1.3	3.6	9.5	1.6	1.6	1.4	0.6	2.9	0.9	2.5	1.6	0.3	3.1	2.3
Number of incorrect matches in round	1.3	2.2	6.1	0.9	1.4	1.7	2.0	-0.4	0.3	1.7	1.3	2.5	1.2	1.7
Diabetes (self-reported)	1.3	2.0	8.2	-2.8	-0.8	-0.0	-1.1	0.4	2.9	-0.5	-1.6	-1.0	-0.5	-0.5
Pulse rate	1.3	2.3	5.4	0.8	0.1	1.5	0.8	2.2	1.5	1.0	1.3	1.2	2.3	2.2
Hair/balding pattern: Pattern 4	1.3	3.1	6.4	0.3	-1.4	-1.9	-1.9	-1.5	-1.0	-1.5	-1.3	-2.3	-2.4	-2.5
Diastolic blood pressure, automated reading	1.3	3.9	11.3	2.0	1.5	1.0	0.5	3.4	-0.6	2.9	1.8	0.4	2.8	2.0
Mean Putamen Volume	1.2	1.4	7.0	-0.0	1.1	1.3	0.9	0.1	2.6	1.0	0.8	0.8	0.7	1.2
Waist Hip Ratio (WHR)	1.2	5.4	10.5	-2.6	-2.6	-1.3	-1.6	-2.9	-1.2	-3.2	-0.9	-1.3	-3.2	-2.9
Pain all over the body in last month	1.2	1.3	2.8	-0.3	-1.0	-0.4	-1.4	-1.7	0.8	-1.0	-1.4	-1.2	-1.3	-1.4
Mouth/teeth dental problems: Dentures	1.2	2.0	5.2	0.5	1.4	2.3	0.9	1.0	2.0	1.6	1.1	0.9	1.5	1.4
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	4.2	-0.2	-0.7	-0.7	-0.8	-1.8	-1.4	-0.8	-1.2	-0.9	-2.1	-1.8
Long-standing illness, disability or infirmity	1.2	1.9	3.4	1.7	1.4	1.4	-0.1	1.8	1.8	1.5	0.7	0.5	1.6	1.2
Commuting to job workplace: Walk	1.2	1.3	3.7	1.6	0.9	1.2	1.4	0.1	-0.1	1.1	1.9	1.0	0.8	1.0
Osteoarthritis (self-reported)	1.2	1.6	2.9	-1.4	-0.9	-1.2	-1.6	-1.0	-1.3	-0.4	-0.9	-1.3	-1.7	-1.7
Ever depressed for a whole week	1.2	1.5	2.7	1.6	1.6	1.1	1.2	1.2	1.3	0.7	1.0	1.2	1.0	1.2
Medication: Metformin	1.1	1.6	9.1	-2.3	0.6	0.6	1.1	-0.5	3.0	-0.1	0.2	0.9	-0.3	0.2
Hearing difficulty/problems with background noise	1.1	1.7	6.5	1.0	1.3	1.4	1.5	-2.6	1.4	-0.4	0.2	1.6	-0.8	-0.1
Hair/balding pattern: Pattern 2	1.1	1.3	6.1	0.5	-1.1	-0.9	-0.4	-0.9	-2.5	-1.6	-0.1	-0.1	-1.2	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	2.6	0.1	1.2	1.4	1.3	1.1	1.5	1.1	1.5	1.4	1.6	1.6
Birth weight of first child	1.1	2.0	5.4	0.3	-1.3	-2.2	-1.4	1.2	-2.3	-0.5	0.7	-2.1	-0.3	-1.3
Medication: Amlodipine	1.1	1.5	4.9	0.8	0.7	0.7	-0.2	1.7	1.5	1.4	0.6	0.4	2.2	1.7
Number of children fathered	1.1	1.2	5.2	0.2	-0.9	-0.5	-0.8	-0.7	0.7	-0.9	-2.3	-1.3	-0.9	-1.2
Medication: Ibuprofen	1.1	1.3	3.0	-0.8	-0.8	-0.8	-0.7	-1.3	-0.8	-1.0	-1.5	-1.1	-1.7	-1.6
Medication: Bendroflumethiazide	1.1	1.7	5.2	0.5	-0.6	-1.8	-2.0	2.0	-0.2	0.7	-0.9	-2.3	0.5	-0.6
Crohns Disease (2017)	1.0	2.2	5.6	0.7	2.4	2.0	1.6	0.9	0.8	1.7	0.5	2.0	0.7	1.5
Blood Red Count	1.0	10.1	20.7	0.6	-3.0	-2.9	-1.5	-4.4	-4.5	-3.3	-1.4	-2.1	-4.1	-4.1
Medication: Co-codamol	1.0	1.1	2.0	0.6	1.0	1.4	1.3	0.8	0.6	1.4	1.1	1.0	1.2	1.1
Nervous feelings	1.0	1.9	3.9	-0.5	-1.2	-1.8	-1.5	-0.6	-2.0	-1.3	-0.4	-1.2	-1.6	-1.9
Heart attack	1.0	1.2	3.4	-0.2	0.9	1.4	1.0	0.8	1.8	0.8	0.4	1.0	1.5	1.5
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	4.2	2.0	0.3	1.0	1.3	-1.9	-1.7	0.1	1.1	1.5	-0.7	-0.0
Age at first live birth	1.0	1.8	3.4	-0.9	-1.7	-1.8	-1.8	0.3	0.2	-1.6	-1.3	-1.8	-0.9	-1.3
Medication: Blood pressure	1.0	1.8	5.9	-0.6	-0.4	-1.0	-2.2	2.4	1.4	0.6	-0.6	-2.0	1.2	0.2
Migraine (self-reported)	1.0	1.3	4.0	-0.2	1.4	1.4	0.6	2.0	1.0	1.3	0.5	0.7	1.0	1.0
Overall health rating	1.0	2.1	10.3	1.1	1.9	1.0	0.5	1.2	3.2	1.5	0.7	0.8	0.8	0.8
High cholesterol (Self-reported)	1.0	1.7	8.5	-2.9	-0.8	-0.7	-0.5	0.3	1.1	-1.3	-2.0	-0.9	-0.9	-0.9
Medication: Atorvastatin	1.0	1.2	5.2	-2.3	-0.3	-0.3	0.2	2.0	1.3	-0.3	-0.7	-0.4	1.0	0.6
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.5	-0.3	0.8	1.3	1.0	1.0	1.9	0.7	0.3	0.9	1.6	1.6
Alcohol drinker status: Previous	1.0	1.1	4.8	-1.2	0.1	1.1	0.8	1.1	2.2	0.2	1.0	0.6	1.0	0.9
HbA1C	0.9	1.0	2.5	-0.6	0.4	0.4	0.6	0.8	1.6	1.4	0.8	0.9	-0.8	1.5
HDL Cholesterol	0.9	1.6	2.8	-1.6	-1.7	-1.5	-1.6	0.3	-1.2	-0.9	-1.2	-1.7	-0.2	-0.7
Schizophrenia (2014)	0.9	1.9	3.0	-0.6	1.7	1.4	1.7	0.7	1.6	1.4	1.5	1.1	1.5	1.3
Age when periods started (menarche)	0.9	2.1	6.5	-1.0	-0.8	-2.3	-2.0	1.6	-1.1	-0.4	-0.9	-2.5	0.2	-0.8
Father’s age at death	0.9	1.2	2.1	1.3	1.2	0.8	1.2	0.4	-0.1	1.2	1.3	1.0	1.4	1.3
Medication: Lansoprazole	0.9	1.0	3.0	-0.5	-0.8	-1.7	-1.2	-0.2	-0.6	0.1	-1.0	-1.6	-0.6	-1.2
Chronic bronchitis/emphysema (mother)	0.9	1.0	6.5	0.4	0.9	0.6	0.0	1.1	2.5	1.2	0.0	-0.0	0.7	0.6
Suffer from ‘nerves’	0.9	1.4	2.9	-0.2	-0.7	-1.2	-1.4	-0.6	-1.4	-0.0	-1.4	-1.6	-1.4	-1.7
Chest pain or discomfort	0.9	1.3	6.1	-0.8	0.2	1.4	0.7	0.7	2.5	0.2	1.1	1.1	1.0	1.1
Medication: Aspirin	0.9	1.2	4.4	-1.7	-0.4	-1.0	-1.3	0.1	1.1	-0.6	-2.1	-1.2	-0.4	-0.6
Smoking status: Previous	0.9	1.3	3.8	0.7	1.5	0.8	0.8	1.2	0.5	1.9	0.8	0.9	1.3	1.2
Medication: Aspirin	0.9	1.1	4.0	-1.7	-0.5	-0.7	-1.0	-0.0	1.2	-1.0	-2.0	-0.8	-0.3	-0.5
Illnesses of father: None of the above (group 1)	0.9	1.1	3.3	-0.5	-0.9	-1.2	-1.3	-0.8	-1.8	-0.9	-1.1	-0.8	-0.8	-0.9
Number of operations (self-reported)	0.9	1.4	4.4	0.0	1.1	0.0	-0.6	1.8	0.3	2.1	0.6	-0.1	1.9	1.3
Hand grip strength (left)	0.8	2.1	5.3	2.3	1.5	1.1	0.6	1.5	0.2	2.0	1.0	0.3	1.9	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	3.4	-0.4	0.1	-0.6	-0.9	-1.6	0.7	-0.1	-0.2	-0.8	-1.8	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	5.3	0.0	-1.3	-0.6	-0.3	-1.4	-0.4	-1.9	-1.4	-1.0	-2.3	-2.1
Multivitamins +/- minerals	0.8	1.1	3.8	-0.0	1.1	0.6	0.5	-1.5	2.0	1.0	1.1	1.1	-0.5	0.1
Had menopause	0.8	0.9	6.4	0.8	0.2	-1.1	-0.1	-0.7	-2.5	0.2	-0.7	-0.7	-0.5	-0.6
Worrier / anxious feelings	0.8	1.5	5.1	-0.4	-0.9	-1.0	-2.3	0.1	-0.9	-0.8	-1.5	-2.1	-0.8	-1.2
High blood pressure (siblings)	0.8	1.2	2.4	-0.3	1.2	0.5	0.5	1.5	1.1	1.5	0.8	0.5	1.5	1.4
Medication for pain relief, constipation, heartburn	0.8	1.4	3.8	0.8	0.9	1.3	1.6	0.1	1.0	0.7	2.0	1.4	0.9	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.1	-1.0	-1.4	-0.5	-0.8	-0.8	0.2	-1.2	-1.3	-1.0	-1.0	-1.0
Number of full sisters	0.8	1.0	3.0	-0.5	-0.9	-1.1	-1.7	0.9	-0.8	-0.6	-0.8	-1.6	0.1	-0.5
Number of self-reported non-cancer illnesses	0.8	1.4	4.2	0.0	1.3	0.1	-0.8	1.9	1.7	2.0	0.3	-0.7	1.1	0.5
Guilty feelings	0.8	1.2	2.5	-1.4	-0.4	-1.2	-1.1	-0.2	0.2	-1.1	-0.9	-1.5	-1.4	-1.6
Eye problems/disorders: Glaucoma	0.8	0.9	1.9	0.7	1.4	0.8	0.3	1.1	0.9	0.9	0.9	0.8	1.0	1.2
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.9	-0.3	-0.5	-1.1	-1.1	-1.0	-0.8	-1.0	-1.7	-1.0	-0.5	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	3.3	0.2	-0.1	-0.1	1.1	0.9	-0.8	0.8	0.1	1.0	1.8	1.8
Irritable Bowel Disease (IBD)	0.7	1.6	3.6	0.6	1.8	1.7	1.0	0.9	1.9	1.7	0.3	1.3	0.5	1.1
Breast Cancer	0.7	1.7	4.9	-1.6	-0.7	-0.8	-2.0	1.3	1.1	-0.5	-2.2	-1.7	0.3	-0.2
Rheumatoid Arthritis	0.7	0.9	4.4	0.7	-0.8	-0.6	-1.1	0.0	-2.1	-0.3	-0.3	-1.2	-0.5	-1.1
Townsend deprivation index at recruitment	0.7	1.0	4.3	-0.2	0.4	1.1	0.8	0.9	0.3	0.5	2.1	1.2	1.1	1.1
Fed-up feelings	0.7	1.3	4.2	-0.4	-0.6	-0.8	-2.1	0.1	-0.5	0.2	-1.2	-2.0	-0.9	-1.4
High blood pressure	0.7	1.9	8.6	0.3	0.7	0.4	-0.5	2.9	1.5	1.7	0.7	-0.7	2.0	1.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.4	-0.9	-1.0	-0.9	-1.6	0.5	0.1	0.3	-1.2	-1.3	0.3	-0.2
Medication: Atenolol	0.7	0.9	6.9	0.0	0.9	1.0	0.5	-0.5	2.6	0.0	-0.2	0.9	-0.3	0.1
Medication: Ramipril	0.7	0.9	3.5	-0.6	-0.6	-0.2	-1.4	0.6	0.2	-0.4	-1.9	-1.4	-0.4	-0.9
Fluid intelligence score	0.7	1.4	3.8	-0.5	-1.0	-1.9	-1.3	1.1	-1.9	-0.3	-1.3	-1.5	0.1	-0.4
Neuroticism score	0.7	1.4	2.8	0.0	-0.5	-1.1	-1.7	-0.3	-1.6	-0.7	-0.7	-1.6	-1.3	-1.7
Alcohol intake versus 10 years previously	0.7	1.1	3.3	0.8	1.4	0.7	0.3	0.7	1.8	1.4	1.3	0.5	0.6	0.7
Birth weight	0.7	1.5	4.5	2.1	1.5	-0.4	-0.3	1.6	-0.3	2.1	1.2	-0.5	1.0	0.4
Number of full brothers	0.7	0.9	2.2	0.3	0.9	1.3	1.5	0.6	1.0	1.2	1.0	1.0	0.1	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	4.0	-2.0	0.0	0.2	0.7	-0.9	0.3	0.1	0.9	1.0	0.5	0.7
Friendships satisfaction	0.7	0.9	1.2	-1.0	-1.0	-0.9	-1.0	1.1	0.4	-1.1	-1.1	-1.1	-0.6	-0.8
Qualifications: nursing, teaching	0.7	1.0	2.0	-1.3	1.0	1.2	0.7	0.5	1.4	0.8	1.0	1.2	0.8	0.9
Back pain experienced in last month	0.7	1.0	2.9	0.7	1.2	0.9	0.3	1.1	1.7	1.6	0.9	0.3	0.8	0.6
Miserableness	0.7	1.1	3.8	1.0	1.1	1.3	0.8	1.9	0.6	0.9	0.9	0.7	1.0	0.7
Vascular/heart problems diagnosed by doctor	0.7	2.0	8.0	0.1	-0.8	-0.7	0.2	-2.8	-1.8	-1.7	-0.6	0.6	-2.1	-1.3
Intelligence (Savage-Jansen 2018)	0.6	2.0	5.2	-2.2	-0.5	-2.3	-1.3	2.0	-1.2	0.3	-0.5	-2.0	0.4	-0.3
Worry (Nagel 2018)	0.6	1.4	3.0	-0.2	-0.2	-1.5	-1.7	-0.7	-1.7	-0.2	-0.7	-1.5	-1.2	-1.5
Verbal and Numeric Reasoning (VNR)	0.6	1.3	4.4	-0.6	-0.9	-1.7	-1.2	1.2	-2.1	-0.5	-0.5	-1.6	-0.1	-0.6
Prostate Cancer	0.6	0.9	4.4	1.4	-0.2	-0.9	-0.7	0.4	-2.1	1.0	0.1	-0.8	0.6	-0.1
Age at First Birth	0.6	0.9	1.8	-0.3	-1.1	-1.4	-0.3	-0.6	-0.6	-1.3	-0.7	-0.8	-1.3	-1.3
Body Mass Index (BMI) (2010)	0.6	0.9	2.8	0.5	-0.1	1.7	0.2	-0.7	1.5	0.4	-0.1	0.7	1.1	1.3
Crohns Disease (2012)	0.6	0.9	3.0	1.7	1.2	1.4	0.8	0.4	-0.5	0.9	-0.1	1.3	-0.0	0.6
BMI	0.6	3.3	8.0	1.0	2.3	0.8	-0.1	2.8	2.6	2.8	1.7	-0.1	1.9	1.1
Cardiovascular Disease	0.6	2.0	8.1	-0.3	1.1	0.2	-0.2	2.8	2.3	1.5	0.9	-0.7	1.7	1.0
Lung FEV1/FVC ratio	0.6	3.0	5.9	1.8	-0.3	-1.6	-1.9	-1.4	-1.5	-0.9	-1.9	-2.1	-2.2	-2.4
Sensitivity / hurt feelings	0.6	1.0	3.5	0.5	1.7	0.4	-0.0	1.9	-0.7	1.0	1.4	-0.2	0.7	0.3
Severe depression (siblings)	0.6	0.6	4.2	-1.4	0.2	0.4	-0.0	-0.1	2.1	-0.4	-0.4	-0.3	-0.3	-0.2
Trunk fat percentage	0.6	2.5	13.6	0.9	0.3	0.4	-0.9	3.7	0.3	2.0	0.2	-0.9	2.3	1.0
Relative age voice broke	0.6	0.9	3.8	1.0	0.7	0.2	-0.0	1.3	-1.9	0.8	1.2	0.4	0.7	0.5
Stomach or abdominal pain in last month	0.6	0.8	1.9	1.0	0.5	0.6	0.3	1.3	1.4	1.0	0.8	0.5	1.1	0.8
Illnesses of siblings	0.6	0.8	2.5	0.6	-0.6	-0.8	-0.2	-1.1	-1.6	-0.8	-0.5	-0.3	-1.2	-1.1
Number of live births	0.6	0.8	3.1	-1.3	-1.0	-1.0	-0.3	0.1	-0.8	-0.8	-1.8	-0.7	-0.1	-0.2
Qualifications: A levels/AS levels or equivalent	0.6	1.3	4.1	0.2	0.6	1.2	0.1	2.0	1.1	0.6	0.1	0.5	1.9	1.7
Lung cancer (father)	0.6	0.7	2.9	-1.2	-0.1	0.8	0.9	-1.7	0.1	-0.7	0.3	1.1	-0.4	0.1
Loud music exposure frequency	0.6	0.6	1.3	0.9	1.1	0.4	1.0	0.2	-0.1	1.1	1.0	1.1	0.1	0.4
Exposure to tobacco smoke outside home	0.6	0.8	1.9	-1.4	-1.0	-1.1	-0.5	-0.3	-0.9	-0.5	-0.5	-1.0	-1.0	-1.2
Wheeze or whistling in the chest in last year	0.6	1.1	9.9	-0.7	-0.2	0.2	-0.0	0.4	3.1	0.3	0.7	-0.9	-0.4	-0.6
Heart disease (mother)	0.6	0.7	5.2	0.4	-0.3	1.5	0.0	0.1	2.3	0.2	-0.0	0.0	0.5	0.5
Leg pain on walking	0.6	0.7	1.4	-0.0	1.2	-0.0	1.1	-0.9	-1.0	0.4	1.2	1.2	-0.5	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.2	0.6	-0.6	-0.8	-0.5	-1.1	-1.1	-0.9	-0.9	-0.4	-0.8	-1.0
Illnesses of father: Heart disease	0.6	0.9	4.1	-1.0	-0.6	0.6	-0.3	-1.2	2.0	-0.8	-1.1	-0.3	-0.4	-0.2
Mood swings	0.6	1.1	2.6	1.0	0.2	-1.0	-1.5	-1.0	-0.4	-0.6	-0.6	-1.3	-1.4	-1.6
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.8	-1.1	-0.9	-0.3	-0.6	-0.6	0.9	-1.3	-1.7	-0.7	-0.9	-0.8
Medication: Gliclazide	0.6	0.7	3.8	-1.7	-0.3	0.2	0.1	-0.2	1.9	-0.5	-0.8	0.0	-0.5	-0.3
Smoking status: Current	0.6	1.0	2.7	0.0	-0.5	-0.7	-0.9	-1.6	-0.8	-0.9	-0.2	-0.7	-1.6	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	4.6	0.2	-1.4	-1.3	-0.8	0.2	-2.1	-1.2	-1.0	-1.0	-0.5	-0.8
Average weekly beer plus cider intake	0.6	0.8	3.1	-0.7	1.1	0.5	0.6	1.0	1.8	0.8	1.0	0.3	0.6	0.6
Depressed Affect (Nagel 2018)	0.5	1.0	3.1	0.1	0.0	-1.0	-1.8	0.1	-0.4	-0.4	-0.8	-1.8	-1.0	-1.4
Schizophrenia (2018)	0.5	1.0	2.0	-1.1	1.1	1.4	1.2	-0.1	1.2	1.1	0.6	1.1	0.7	1.0
Reaction Time	0.5	0.9	2.6	1.6	0.9	-0.2	0.6	0.7	-1.4	0.9	1.4	0.8	0.5	0.4
Bipolar Disorder (2011)	0.5	0.5	2.2	-0.3	0.3	1.1	-0.2	-1.1	1.5	0.6	-0.0	-0.4	-0.4	-0.3
Triglycerides	0.5	0.9	3.4	-1.4	0.1	0.9	0.5	-1.6	1.8	-0.3	-0.1	0.4	-0.6	-0.1
Ever used hormone-replacement therapy (HRT)	0.5	0.6	3.4	0.7	1.2	0.1	0.3	0.4	-0.1	1.8	0.4	-0.2	0.8	0.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.2	0.6	1.0	0.0	0.4	1.5	0.5	0.7	1.1	0.5	0.6	0.5
Body mass index (BMI)	0.5	2.3	6.8	0.9	1.6	1.3	0.1	2.6	1.5	2.2	1.4	0.1	1.7	1.1
Had other major operations	0.5	0.6	1.4	1.2	0.8	0.4	0.7	1.2	0.0	1.0	0.0	0.6	0.9	0.6
Qualifications: None of the above	0.5	1.0	1.8	1.1	1.4	1.0	1.2	1.0	0.6	0.8	1.3	1.0	0.6	0.7
Happiness	0.5	0.6	1.3	-0.2	-0.1	-1.1	-0.9	0.1	0.3	-0.9	-0.1	-0.8	-1.1	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.9	-1.7	-0.7	0.7	-0.1	-0.9	0.8	-0.8	-0.4	0.6	-0.3	0.2
Illnesses of mother	0.5	0.6	1.9	-1.3	0.1	-0.9	-0.0	-1.4	-0.8	-0.5	-0.3	0.0	-0.9	-0.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.3	1.3	0.4	0.5	1.5	-0.7	0.3	-0.0	0.4	1.1	-0.7	-0.3
Gout (self-reported)	0.5	0.7	3.0	1.7	0.6	0.9	0.3	-1.0	1.1	0.1	0.6	0.6	-0.1	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.7	0.2	-0.4	0.7	-0.0	1.2	-0.2	-0.4	0.2	0.5	1.3	1.2
Health satisfaction	0.5	0.6	5.3	-0.4	0.5	-0.5	0.2	0.5	2.3	0.5	-0.0	0.2	-0.1	0.1
Neck or shoulder pain in last month	0.5	0.7	1.8	1.1	0.9	-0.2	0.8	-1.0	1.3	-0.3	0.0	0.2	-1.1	-0.7
Pulse rate, automated reading	0.5	1.5	2.7	-1.4	-0.9	1.2	1.4	1.6	0.5	0.3	1.0	1.0	1.6	1.6
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.5	-0.9	-0.2	-1.2	-0.9	0.9	-1.1	0.0	-0.8	-0.8	0.4	0.1
Hypertension (Self-reported)	0.5	1.4	7.1	0.3	0.4	0.0	-0.7	2.7	1.1	1.3	0.6	-0.9	1.8	0.9
Illnesses of siblings: Diabetes	0.5	0.6	1.5	-1.2	0.4	0.6	0.2	1.1	0.9	0.6	1.0	0.4	0.4	0.5
Mineral and other dietary supplements	0.5	0.7	3.7	-0.4	-1.0	0.2	-0.3	1.9	0.3	-0.5	0.7	-0.2	1.1	0.6
Breast cancer (self-reported)	0.5	0.5	1.5	-1.2	-1.0	-0.6	-0.5	-0.5	-0.2	-1.2	-0.6	-0.2	-0.6	-0.6
Medication: Lisinopril	0.5	0.7	3.2	-1.3	0.2	-0.4	-0.1	1.5	1.8	0.4	-0.1	-0.4	0.4	0.4
Supplements: Calcium	0.5	0.6	1.3	0.9	0.9	0.7	0.4	0.9	-0.5	0.4	-0.2	0.8	1.0	1.2
Bipolar Disorder or Schizophrenia	0.4	0.9	3.2	-0.9	0.7	1.3	0.7	0.5	1.8	1.2	0.3	0.4	0.7	0.8
Coronary Artery Disease (CAD)	0.4	0.4	1.5	1.2	-0.0	0.1	-0.3	1.1	0.1	-0.3	-0.7	-0.3	-0.8	-0.8
Ulcerative Colitis	0.4	0.6	1.7	0.3	0.6	0.3	0.8	1.1	1.3	1.1	0.4	0.7	0.3	0.4
Hypothyroidism (self reported)	0.4	1.0	3.1	-1.0	-0.1	-1.4	-1.3	-0.2	0.4	0.4	-0.5	-1.8	-0.9	-1.2
Lung FVC	0.4	2.3	9.4	1.6	0.2	-0.1	0.1	1.2	-3.1	0.5	1.4	0.8	2.3	1.9
Hearing difficulty/problems: Yes	0.4	0.7	3.6	1.9	0.9	0.6	0.1	-0.8	-0.8	-0.5	-0.3	0.5	-0.8	-0.5
Vitamin and mineral supplements	0.4	0.5	1.7	0.6	-0.9	0.4	0.4	1.3	-0.9	-1.0	-0.3	-0.1	0.5	0.2
Diabetes (father)	0.4	0.5	2.7	-1.6	-0.7	0.2	0.6	0.2	1.3	-0.8	-0.0	0.1	0.1	0.2
Current tobacco smoking	0.4	0.7	2.5	0.1	-0.2	-0.4	-0.7	-1.6	-0.2	-0.6	-0.1	-0.6	-1.4	-1.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	2.5	1.6	1.2	-0.7	0.1	0.3	0.4	0.4	0.5	-0.2	-0.1	-0.2
Medication: Levothyroxine sodium	0.4	0.7	1.5	-0.9	0.1	-1.0	-1.2	-0.3	1.1	0.3	-0.8	-1.1	-0.6	-0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.2	1.1	0.7	0.7	0.9	0.1	0.5	0.0	0.6	1.1	0.1	0.4
Mouth/teeth dental problems	0.4	0.6	3.8	0.9	-0.2	-1.0	-0.2	-0.9	-1.9	-0.1	0.1	0.2	-0.7	-0.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.8	0.9	1.3	0.4	0.4	0.6	0.9	0.3	0.7	0.7	-0.3	0.3
Hair/balding pattern: Pattern 3	0.4	0.6	1.9	-0.4	-0.7	-0.8	-1.2	-0.4	0.2	-0.3	-0.7	-1.4	-0.7	-0.9
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.0	-0.8	0.2	-1.0	-1.2	0.1	0.9	0.7	-0.3	-1.4	-0.7	-1.1
Medication: Ventolin 100micrograms inhaler	0.4	0.5	3.5	0.8	-0.0	-0.0	0.3	-1.9	0.5	0.0	0.5	0.1	-0.7	-0.6
Body fat percentage	0.4	1.5	9.2	0.6	0.0	0.1	-1.1	3.0	-0.0	1.4	-0.1	-1.2	1.4	0.3
Qualifications: College or University degree	0.4	1.2	4.9	-2.2	-1.1	-0.1	-1.1	1.0	1.0	-0.8	-1.6	-0.6	0.6	0.4
Angina (self-reported)	0.4	0.6	2.4	-1.3	0.4	0.4	-0.1	0.9	1.5	0.2	-0.4	-0.2	0.7	0.7
Alcohol intake frequency.	0.4	0.9	1.7	-0.5	-1.1	-1.3	-1.1	0.2	-0.7	-1.2	0.0	-1.2	-0.9	-1.1
Had major operations	0.4	0.5	1.3	0.5	0.4	-0.1	-1.1	0.6	-0.3	1.0	0.6	-0.5	0.9	0.7
Age at last live birth	0.4	0.6	1.9	-0.5	-0.8	-0.6	-0.6	1.4	1.2	-0.4	-0.7	-0.5	0.8	0.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.8	0.8	0.3	-0.9	-1.3	0.0	-0.4	0.6	-0.3	-1.0	-0.1	-0.5
Loneliness, isolation	0.4	0.6	2.7	-0.8	-0.3	0.4	0.3	-0.4	1.6	-0.8	0.7	0.0	-0.9	-0.7
Asthma (self-reported)	0.4	0.9	2.8	-0.0	0.5	0.5	1.6	0.5	1.6	0.7	1.7	0.8	0.2	0.4
Commuting to job workplace: Public transport	0.4	0.5	3.1	0.1	-0.5	1.2	0.4	0.1	1.7	-0.1	0.5	0.5	0.4	0.5
Medication: Paracetamol	0.4	0.7	2.0	0.5	-0.6	-1.0	-1.2	0.5	-0.4	-0.1	-1.0	-1.4	-0.4	-0.9
Heart disease (siblings)	0.4	0.5	2.0	-0.3	-0.2	0.4	0.9	-0.5	1.4	-1.0	-0.4	0.5	-0.6	-0.2
Ulcerative Colitis (UC)	0.3	0.5	4.1	-0.1	0.4	0.4	-0.0	0.2	2.0	0.9	-0.2	0.2	-0.1	0.1
Major Depression (MDD)	0.3	0.3	1.2	0.7	0.9	-0.2	0.2	1.1	0.7	-0.3	0.2	-0.4	-0.4	-0.5
Ovarian Cancer	0.3	0.3	1.3	-0.4	0.4	-0.7	0.6	-1.1	0.7	0.2	0.8	0.3	-0.2	-0.0
Neuroticism	0.3	0.8	2.9	0.4	0.3	-0.9	-1.7	0.2	-1.5	0.1	-0.4	-1.3	-0.4	-0.9
Number of treatments/medications taken	0.3	0.6	2.7	-0.5	-0.0	-0.3	-0.9	0.6	1.6	0.7	-0.8	-0.8	0.5	0.1
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.4	0.1	-0.0	-0.7	-0.9	-0.5	-0.0	-0.1	-0.3	-0.8	-1.1	-1.2
Relative age of first facial hair	0.3	0.7	1.9	0.7	0.8	0.6	0.6	0.3	-0.8	0.9	1.4	0.9	0.8	0.7
Angina	0.3	0.5	1.9	-1.4	0.2	0.3	-0.3	0.7	1.3	-0.1	-0.3	-0.3	0.6	0.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.2	-0.6	0.2	0.2	-0.2	0.7	0.7	1.1	0.0	-0.1	0.9	0.8
Past tobacco smoking	0.3	0.5	1.9	0.0	-0.8	-0.7	-0.4	-0.5	-0.5	-1.4	-0.8	-0.6	-0.7	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	1.1	0.6	0.7	0.4	0.2	1.1	1.0	0.9	0.1	0.0	-0.1
Arm fat percentage (right)	0.3	1.0	4.5	1.4	0.2	-0.0	-1.1	2.1	-0.0	1.1	-0.2	-1.1	0.7	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.1	1.1	0.9	-0.2	-0.9	0.4	0.1	1.0	0.7	-0.4	0.4	0.1
Asthma	0.3	0.6	2.6	-0.2	0.3	0.2	1.4	0.3	1.1	0.5	1.6	0.7	0.1	0.3
Pulse wave Arterial Stiffness index	0.3	0.4	1.1	-0.2	0.1	0.7	0.5	0.5	1.1	0.3	0.9	0.3	0.7	0.6
Length of working week for main job	0.3	0.3	1.7	-0.7	-0.7	0.1	-0.2	-0.4	-0.3	-0.1	-1.3	0.0	0.1	0.2
Exposure to tobacco smoke at home	0.3	0.3	1.4	0.3	0.0	0.6	1.1	-0.3	-0.2	-0.3	-0.1	1.2	0.1	0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.7	0.4	0.7	-0.3	-1.3	0.5	1.1	0.2	-0.3	-0.8	0.6	0.2
Medication: Paracetamol	0.3	0.4	1.4	0.7	-0.3	-0.4	-1.1	1.2	-0.5	0.3	-0.6	-0.8	0.3	-0.2
Shortness of breath walking on level ground	0.3	0.4	1.1	-0.0	1.1	-0.6	1.0	-0.1	0.3	0.4	0.7	0.8	-0.2	0.0
Emphysema/chronic bronchitis	0.3	0.3	0.7	0.6	0.7	0.6	0.1	-0.6	0.7	0.6	0.5	0.2	-0.8	-0.6
Medication: Omeprazole	0.3	0.4	1.3	0.2	-0.4	-0.2	0.4	0.3	-0.8	0.4	-0.5	0.4	1.1	1.2
Medication: Seretide 50 evohaler	0.3	0.3	1.9	0.6	0.4	-0.7	0.3	0.1	-0.3	0.1	1.4	0.1	-0.3	-0.5
Supplements: Vitamin C	0.3	0.3	1.0	-0.3	0.0	-0.5	-1.0	0.2	1.0	-0.3	-0.8	-0.5	-0.2	-0.2
Ever taken oral contraceptive pill	0.3	0.3	1.2	-0.8	0.3	0.1	0.4	0.2	1.1	0.2	0.9	-0.1	0.6	0.3
Mother’s age at death	0.3	0.4	2.0	0.1	-0.9	-0.4	0.5	0.0	-1.4	-0.7	-0.5	0.3	-0.1	0.2
Leg fat percentage (left)	0.3	1.0	4.4	-0.9	-0.4	-0.2	-1.4	2.1	0.3	0.2	-0.8	-1.5	0.0	-0.7
Bipolar Disorder (2018)	0.2	0.4	2.0	-0.1	-0.2	0.4	-0.4	1.0	1.4	0.6	-0.2	-0.7	0.4	-0.1
Schizophrenia vs Biploar Disorder	0.2	0.2	1.3	-1.1	0.6	-0.0	-0.2	0.3	-0.6	-0.0	-0.1	0.3	0.6	0.4
Neuroticism (2016)	0.2	0.3	1.0	0.6	0.4	-0.5	-1.0	0.5	-0.1	0.7	0.0	-0.6	0.4	-0.2
Systolic Blood Pressure	0.2	1.0	4.7	-0.1	0.2	0.0	-0.1	1.5	2.2	1.1	-0.2	-0.6	1.4	0.9
Respiratory disease	0.2	0.4	1.3	-0.3	0.7	-0.3	0.5	-0.3	1.2	0.7	0.7	-0.0	-0.8	-0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.8	0.9	0.5	0.3	-0.2	0.7	-0.0	0.7	-0.0	0.4	0.3	0.2
Systolic blood pressure, automated reading	0.2	0.5	2.1	-0.2	-0.6	-0.3	-1.2	0.1	0.0	0.4	-1.0	-1.4	0.1	-0.3
Serious illness, injury or assault to yourself	0.2	0.2	1.1	-0.5	-0.1	0.2	-0.0	1.0	0.6	0.8	-0.0	-0.2	0.4	0.1
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.9	0.8	0.4	-0.2	-0.1	-1.4	0.5	-0.2	0.0	0.2	-0.8	-0.4
Supplements: Glucosamine	0.2	0.2	0.5	-0.7	0.2	-0.6	-0.2	-0.6	-0.6	0.3	-0.4	-0.1	-0.6	-0.5
Allergy	0.2	0.5	2.0	-0.4	-0.9	0.1	-0.5	0.8	-1.4	-0.9	-0.8	-0.4	0.3	0.0
Medication: Simvastatin	0.2	0.3	2.1	-0.5	0.5	0.2	-0.1	0.0	1.4	-0.1	-0.8	-0.2	-0.2	-0.1
Time employed in main current job	0.2	0.2	0.6	0.5	-0.3	-0.3	-0.6	-0.0	0.8	-0.2	-0.5	-0.4	0.5	0.4
Breastfed as a baby	0.2	0.3	1.5	-0.3	-0.1	-0.1	0.6	-0.8	-1.2	-0.1	0.7	0.4	-0.1	-0.1
Pulse wave reflection index	0.2	0.2	1.3	-0.2	-0.0	-0.3	-0.2	-1.1	-0.6	-0.3	0.3	-0.4	-0.2	-0.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.8	-0.6	-0.7	-0.0	-0.0	0.5	0.9	0.0	0.4	-0.6	0.5	-0.0
Leg fat percentage (right)	0.2	0.8	4.1	-0.4	-0.3	-0.0	-1.3	2.0	0.2	0.2	-0.9	-1.4	-0.0	-0.7
Family relationship satisfaction	0.2	0.2	0.6	0.3	0.5	-0.8	-0.5	-0.3	-0.5	0.0	-0.1	-0.4	-0.8	-0.6
Arm fat percentage (left)	0.2	0.9	4.7	0.9	-0.1	-0.2	-1.1	2.2	-0.2	1.1	-0.2	-1.1	0.8	-0.2
Alcohol drinker status: Never	0.2	0.3	1.1	0.2	0.1	-0.3	-1.1	0.9	-0.6	-0.0	-0.4	-0.6	0.1	0.0
Ever smoked	0.2	0.3	0.9	0.2	0.5	0.7	0.3	-0.4	0.8	0.9	0.9	0.4	0.1	0.2
Risk taking	0.2	0.4	2.6	0.8	0.1	0.1	0.3	1.6	0.1	0.5	-0.4	-0.3	0.3	-0.0
Pain experienced in last month	0.2	0.3	1.1	-0.9	-1.0	-0.5	-0.5	0.4	-0.3	-0.4	-0.1	-0.6	0.5	0.3
LDL Cholesterol	0.1	0.2	1.0	-0.3	-0.5	-0.5	0.8	0.0	-0.2	-0.2	1.0	-0.0	0.4	0.3
Blood White Count	0.1	1.0	4.6	-2.1	-0.3	0.4	-0.6	-0.5	2.1	-0.5	-0.7	-0.4	-0.5	-0.2
Smoking Status	0.1	0.3	1.4	0.1	1.0	0.1	-0.4	-0.4	0.6	1.2	0.5	0.1	-0.3	-0.2
Allergy or Eczema	0.1	0.3	2.0	0.7	0.3	-0.4	-0.2	-1.4	0.3	-0.4	0.2	0.2	-0.5	-0.2
Chronotype (morning person)	0.1	0.3	0.8	0.6	-0.1	-0.3	0.1	-0.6	-0.5	-0.9	-0.6	0.0	-0.8	-0.7
Diabetes (mother)	0.1	0.1	0.5	0.0	0.2	0.7	0.0	0.2	0.3	0.5	0.3	-0.1	0.1	0.0
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.5	-0.2	-0.3	-0.4	0.4	-0.1	0.1	-0.1	-0.5	-0.3	-0.5
Alcohol usually taken with meals	0.1	0.2	0.5	0.7	0.1	0.3	0.5	-0.3	-0.7	0.0	-0.2	0.7	0.3	0.7
Tense / ‘highly strung’	0.1	0.1	1.1	-0.1	-0.2	0.1	-0.4	-0.0	-1.0	0.2	-0.1	-0.1	0.0	-0.1
Pulse wave peak to peak time	0.1	0.2	0.6	0.8	0.6	-0.1	-0.1	0.1	-0.6	0.5	-0.2	0.1	0.1	0.1
Mean time to correctly identify matches	0.1	0.1	0.2	0.0	0.3	-0.5	0.0	-0.4	-0.4	0.0	-0.0	0.5	-0.5	-0.4
Average weekly red wine intake	0.1	0.2	1.8	0.0	-0.2	-0.2	-0.4	0.0	0.2	-0.4	-1.3	-0.3	0.1	0.1
Ever had bowel cancer screening	0.1	0.1	0.3	-0.4	0.4	-0.2	0.1	0.1	0.1	0.1	-0.6	-0.0	-0.4	-0.3
Medication for cholesterol	0.1	0.1	0.5	-0.4	-0.4	-0.1	0.3	0.1	0.2	-0.7	-0.3	0.1	-0.0	0.1
Hearing aid user	0.1	0.2	0.9	1.0	-0.1	-0.2	-0.1	-0.4	-0.7	-0.4	-0.3	0.1	-0.1	-0.0
Medication: Blood pressure	0.1	0.3	0.9	0.8	0.7	0.0	-0.4	0.5	0.5	0.9	-0.1	-0.2	0.3	-0.0
Cholesterol lowering medication	0.1	0.2	0.8	-0.3	0.9	-0.2	-0.2	0.7	0.2	0.7	0.2	-0.3	-0.2	-0.3
Alzheimer’s Disease (in father)	0.0	0.0	0.1	0.1	0.1	-0.0	-0.1	-0.3	0.2	-0.2	-0.0	0.2	-0.4	-0.2
Blood Eosinophil Count	0.0	0.4	1.5	0.6	-1.0	-0.1	-0.7	0.3	0.2	0.0	-1.2	-0.5	0.5	0.1
Fractured/broken bones in last 5 years	0.0	0.1	0.2	-0.2	0.1	0.2	0.3	-0.0	-0.3	0.2	-0.2	-0.1	-0.4	-0.3

Hub : Genes

CBFA2T2

Models

Trait associations