Hub : Genes

PDE11A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0470	0.0169	6.2e-05	0.037	0.044	0.035	0.042	0.042	1.2e-05	1.9e-06	2.5e-05	3.7e-06	3.5e-06
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0678	0.0338	2.1e-03	0.018	0.023	0.024	NA	0.032	3.3e-03	1.2e-03	8.3e-04	NA	1.5e-04
3	TCGA	Brain Lower Grade Glioma	0.0680	0.0297	5.6e-05	0.018	0.044	0.042	NA	0.037	3.2e-03	8.8e-06	1.5e-05	NA	4.3e-05
4	TCGA	Lung Adenocarcinoma	0.1370	0.0533	1.5e-03	-0.001	0.029	0.035	NA	-0.002	5.4e-01	2.2e-04	5.4e-05	NA	9.5e-01
5	TCGA	Prostate Adenocarcinoma	0.1382	0.0382	7.1e-14	0.122	0.145	0.163	NA	0.176	1.0e-12	6.1e-15	8.8e-17	NA	4.5e-18

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	0.8	0.6	0.2	-0.1	0.9	0.3
Bipolar Disorder or Schizophrenia	0.2	0.5	1.4	0.3	0.6	-0.2	0.7	1.2
Depressed Affect (Nagel 2018)	0.7	1.5	3.0	-1.2	-0.6	-1.7	-0.3	1.6
Depression (Nagel 2018)	0.9	1.4	2.1	-0.8	-1.2	-0.9	-1.5	1.4
Intelligence (Savage-Jansen 2018)	0.5	1.7	5.2	-0.1	0.8	-1.1	-2.3	1.1
Neuroticism (Nagel 2018)	1.7	4.1	9.1	-2.6	-1.2	-3.0	-0.7	1.5
Schizophrenia (2018)	0.2	0.4	1.7	-0.1	0.6	-0.2	0.3	1.3
Schizophrenia vs Biploar Disorder	1.3	1.7	5.4	-1.1	0.3	-1.1	-0.8	2.3
Worry (Nagel 2018)	1.0	2.2	5.3	-2.3	-1.4	-1.9	-0.1	0.2
Alzheimer’s Disease (in mother)	0.5	0.6	1.7	0.8	0.7	0.7	-1.3	-0.0
Alzheimer’s Disease (in father)	0.6	0.7	1.5	-0.2	0.4	0.6	1.1	-1.2
Alzheimer’s Disease (including proxy)	0.9	1.2	2.9	1.4	0.9	1.7	-0.3	-0.6
Crohns Disease (2017)	1.3	2.9	5.9	-1.4	-0.9	-2.4	-0.5	2.3
Irritable Bowel Disease (IBD)	0.8	1.9	4.7	-1.3	-0.9	-2.2	-0.9	1.2
Ulcerative Colitis (UC)	0.3	0.6	1.4	-0.8	-0.1	-0.9	-1.2	-0.2
Major Depression (MDD)	0.4	0.5	1.5	0.1	1.2	0.0	-0.8	0.5
Reaction Time	0.4	0.7	3.1	0.4	-0.1	0.4	-0.4	1.8
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.4	-0.6	0.1	-1.5	-0.3	0.6
Breast Cancer	0.4	1.0	3.1	-0.3	0.3	-0.9	0.9	1.8
Ovarian Cancer	0.2	0.3	1.1	-0.2	1.1	-0.3	0.4	-0.3
Prostate Cancer	1.8	2.5	8.0	-1.1	-1.8	0.4	-0.2	-2.8
Age at First Birth	0.7	1.0	2.6	0.5	-1.6	0.3	-0.9	-1.2
Bipolar Disorder (2011)	1.6	1.5	5.2	1.1	-0.7	0.7	2.3	0.5
Body Mass Index (BMI) (2010)	0.8	1.1	2.6	1.3	1.6	1.0	-0.4	-0.2
Coronary Artery Disease (CAD)	1.3	1.5	2.8	1.1	0.4	1.7	1.2	-1.4
Crohns Disease (2012)	0.7	1.1	1.6	-0.9	-0.7	-1.2	1.0	1.2
Mean Putamen Volume	0.5	0.5	1.5	-0.4	0.8	-1.2	0.2	0.6
Fasting Glucose	0.9	1.1	2.9	-0.5	-0.9	0.0	1.2	-1.7
HbA1C	1.9	2.1	6.0	-1.9	-0.5	-2.4	0.0	0.7
HDL Cholesterol	0.4	0.7	3.3	0.1	-1.8	0.1	0.1	-0.6
LDL Cholesterol	0.8	1.3	4.5	-0.5	-0.1	-1.2	0.6	2.1
Lupus	1.1	1.6	4.4	1.1	-0.8	0.6	-2.1	-1.2
Neuroticism (2016)	1.0	1.5	2.8	-1.3	-0.7	-1.5	-1.7	0.5
Primary Biliary Cirrhosis	0.1	0.2	0.8	-0.2	0.2	-0.9	0.1	0.2
Rheumatoid Arthritis	0.8	1.1	2.1	0.4	1.3	1.2	-1.5	-0.4
Schizophrenia (2014)	0.3	0.6	2.3	0.2	0.5	-0.0	0.3	1.5
Triglycerides	0.8	1.4	2.9	-0.5	0.9	-1.0	1.4	1.7
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.9	-0.5	1.4	-0.1	0.2	-0.5
Ulcerative Colitis	1.1	1.6	4.6	-2.1	-0.6	-1.5	-0.3	-0.7
Blood Eosinophil Count	0.2	1.9	4.8	-1.6	0.9	-2.2	-0.2	1.2
Blood Platelet Count	0.3	3.3	10.2	1.6	1.0	1.5	3.2	-0.7
Blood Red Count	0.4	4.0	10.5	1.3	-0.2	3.2	1.8	-2.2
Blood White Count	0.2	1.2	2.9	0.6	-0.6	0.0	1.7	1.6
Heel T-Score	0.4	3.2	7.1	-2.7	-1.3	-2.2	-0.7	1.4
BMI	0.9	5.3	12.8	3.6	1.9	3.0	-1.1	-0.5
Height	0.7	13.5	42.2	-2.1	-0.5	-2.8	-3.6	-6.5
Waist Hip Ratio (WHR)	1.1	4.9	8.8	3.0	3.0	2.5	-0.4	0.5
Systolic Blood Pressure	0.1	0.4	1.1	-0.5	0.0	-0.7	1.0	-0.1
Smoking Status	0.5	1.3	2.8	-1.1	0.3	-1.3	0.9	1.7
Allergy or Eczema	0.6	1.5	5.0	-1.0	-2.2	-0.3	1.2	-0.1
Cardiovascular Disease	0.3	0.9	3.3	-0.7	0.7	-1.8	-0.2	0.1
Hypothyroidism (self reported)	0.3	0.7	2.0	0.2	1.4	1.0	0.5	-0.1
Respiratory disease	0.5	1.0	2.7	1.6	0.3	1.4	0.6	0.3
Type 2 Diabetes (T2D) (2018)	0.5	1.0	3.5	0.3	0.9	-0.7	-1.9	-0.3
Lung FEV1/FVC ratio	0.4	2.1	4.8	1.2	-0.8	1.9	2.2	0.0
Lung FVC	4.3	21.9	54.6	-7.0	-1.5	-7.4	-1.6	1.2
Neuroticism	1.5	3.6	6.9	-2.0	-1.4	-2.6	-1.2	2.0
Chronotype (morning person)	0.3	0.7	2.5	-0.2	-0.0	-0.4	-1.6	-0.8
Hair Pigment	0.2	4.6	7.8	2.3	-0.7	2.8	-1.5	-2.7
Tanning	0.1	0.7	2.6	-0.6	-0.6	0.5	1.6	-0.3
Hand grip strength (left)	0.6	1.6	3.7	0.5	1.9	-0.6	-1.9	-0.4
Number of treatments/medications taken	0.1	0.2	0.4	-0.4	0.7	-0.5	-0.0	0.1
Average weekly spirits intake	0.5	0.7	1.8	-1.3	-0.7	-0.7	0.4	-0.7
Sensitivity / hurt feelings	2.0	3.5	7.5	-2.6	1.3	-2.7	-1.1	0.5
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.7	-0.9	-1.0	-0.7	-1.3	0.6
Hearing difficulty/problems: Yes	1.3	2.0	5.9	2.4	1.0	1.5	-0.8	0.1
Relative age of first facial hair	0.4	0.9	1.6	1.0	0.2	1.3	-1.2	-0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	1.1	-0.5	-0.2	0.5	-1.1	-0.2
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.7	-0.9	0.3	-1.0	-0.1	1.3
Ever had hysterectomy (womb removed)	2.5	2.8	4.9	-2.2	-1.5	-1.7	1.7	1.1
Systolic blood pressure, automated reading	0.1	0.3	1.0	0.2	-0.5	0.3	1.0	0.4
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.8	1.3	0.9	0.4	-1.7	1.0
Angina	0.7	0.9	2.6	1.0	0.5	0.9	-0.2	1.6
Medication for hormone replacement therapy	1.1	1.3	2.8	-0.6	-0.9	-0.7	-1.4	-1.7
Vitamin and mineral supplements	0.3	0.5	1.1	0.5	-0.2	1.0	1.0	-0.1
Supplements: Zinc	0.4	0.4	1.0	0.8	0.5	0.4	-1.0	-0.0
Medication: Co-codamol	0.3	0.3	0.6	0.8	0.2	0.3	0.6	0.6
Medication: Metformin	1.2	1.7	5.8	0.4	1.5	-0.2	-2.4	0.6
Diabetes (father)	0.9	1.1	1.8	1.4	0.6	1.1	0.9	-1.0
Diabetes (mother)	0.2	0.3	0.8	0.9	-0.3	0.6	-0.1	-0.4
Severe depression (siblings)	0.8	0.9	1.8	-0.8	0.2	-0.8	-1.2	1.4
Pack years adult smoking proportion	1.0	1.6	6.1	0.2	-0.1	-1.4	-0.1	2.5
Impedance of leg (right)	0.2	1.1	2.1	0.5	1.2	1.4	1.4	-0.2
Leg fat-free mass (left)	0.5	2.9	7.9	0.3	-0.4	-0.7	-2.4	-2.8
Trunk fat percentage	1.7	6.7	14.2	3.8	1.6	3.4	-1.9	-1.4
Hand grip strength (right)	0.6	1.6	2.8	0.1	1.6	-1.4	-1.7	0.7
Townsend deprivation index at recruitment	0.6	0.8	1.4	1.1	0.7	0.6	-1.2	0.8
Current tobacco smoking	0.3	0.5	1.2	-1.0	-0.2	-1.1	0.0	0.5
Average weekly fortified wine intake	0.8	1.0	2.9	-0.1	-0.2	-0.6	-1.7	1.2
Maternal smoking around birth	0.8	1.1	3.1	1.0	1.8	0.9	-0.9	0.1
Fed-up feelings	1.0	1.8	6.2	-0.0	1.1	-0.2	-2.5	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.6	-0.3	0.1	-0.7	-1.2	1.6
Relative age voice broke	0.4	0.6	1.5	0.7	-0.3	0.5	-1.2	-0.9
Taking other prescription medications	1.9	3.0	6.5	2.1	2.6	2.0	0.1	-0.1
Age when periods started (menarche)	1.3	3.2	11.9	0.7	3.5	0.1	1.5	1.1
Bilateral oophorectomy (both ovaries removed)	5.0	5.8	10.2	-3.2	-2.8	-2.9	0.9	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.6	-0.4	-0.2	-0.7	0.6	-0.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.5	-0.2	-0.5	-0.1	0.6	1.2
Qualifications: CSEs or equivalent	0.7	0.9	1.9	0.2	0.8	0.4	-1.4	-1.2
Serious illness, injury or assault to yourself	1.9	2.2	4.6	2.1	0.8	2.0	-1.1	1.0
High blood pressure	0.2	0.5	1.4	1.2	0.4	0.4	-0.8	0.4
Hayfever, allergic rhinitis or eczema	0.7	1.6	5.0	-0.9	-2.2	-0.4	1.3	0.3
Multivitamins +/- minerals	0.4	0.5	0.9	-0.3	0.3	-0.9	-0.8	-1.0
Stomach or abdominal pain in last month	1.7	2.1	5.2	2.3	-0.5	2.2	0.1	-0.7
Supplements: Glucosamine	0.6	0.8	1.6	-0.9	0.3	-1.1	0.4	1.2
Diverticular disease/diverticulitis (self-reported)	1.5	1.7	3.8	1.9	0.6	1.9	0.9	-0.4
Medication: Atenolol	0.7	0.9	3.8	0.5	-0.3	-0.1	-1.9	0.3
Medication: Levothyroxine sodium	1.6	2.6	4.6	1.6	2.1	2.1	-0.9	-0.9
Sitting height	2.0	14.1	33.4	-4.4	-3.1	-5.8	-1.9	-2.0
Chronic bronchitis/emphysema (father)	0.4	0.4	1.2	-0.5	-0.1	-0.7	-1.1	-0.4
High blood pressure (mother)	0.6	0.9	4.4	0.1	-0.1	0.2	-2.1	0.2
Body mass index (BMI)	1.3	5.5	13.7	3.7	1.1	2.9	-1.9	-0.7
Impedance of leg (left)	0.3	1.5	2.9	0.8	1.1	1.6	1.7	0.2
Leg predicted mass (left)	0.6	3.1	8.2	0.2	-0.5	-0.7	-2.5	-2.9
Trunk fat mass	1.3	5.5	11.2	3.4	1.2	2.7	-2.1	-1.9
Waist circumference	1.8	6.5	12.9	3.6	2.3	2.9	-1.8	-1.5
Number of incorrect matches in round	0.5	0.8	1.6	-1.3	-0.8	-0.1	-0.2	-1.2
Past tobacco smoking	0.9	1.7	3.3	-1.8	-1.2	-1.8	-0.5	-0.7
Alcohol usually taken with meals	2.6	4.2	6.8	-2.2	-1.7	-2.6	2.3	1.2
Nervous feelings	1.3	2.4	5.6	-2.4	-1.7	-1.5	1.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.1	-1.4	-0.8	-1.2	-1.4	0.4
Hearing difficulty/problems with background noise	1.5	2.4	3.5	1.9	1.9	1.2	-1.3	1.4
Hair/balding pattern: Pattern 2	1.6	2.0	6.3	0.8	1.7	0.1	-2.5	-0.4
Had menopause	0.7	0.8	2.8	-1.7	-0.2	-1.1	-0.3	0.3
Had other major operations	2.9	3.5	8.8	3.0	0.8	2.2	1.1	1.3
Forced vital capacity (FVC)	3.4	13.1	33.8	-5.4	-0.4	-5.8	-1.4	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	0.9	-0.8	-1.0	-0.9	0.3	0.8
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.9	-1.1	-0.5	-1.1	-1.7	0.7
Qualifications: None of the above	1.3	2.7	4.5	2.1	-0.1	2.1	1.9	1.1
Financial difficulties in last 2 years	0.5	0.6	0.9	0.9	0.8	0.8	-1.0	-0.1
Mouth/teeth dental problems	3.1	4.8	8.4	-2.9	-1.8	-1.6	1.8	-2.6
Heart attack	0.8	1.0	2.3	0.2	1.0	0.4	-1.2	-1.5
Allergy	0.4	0.9	2.0	-0.7	1.2	-0.7	-1.4	-0.2
Pain all over the body in last month	1.3	1.4	2.2	0.2	-1.1	1.1	-1.4	-1.5
Diabetes (self-reported)	0.9	1.3	4.5	-0.5	-0.2	-1.2	-2.1	-0.6
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	0.0	0.2	0.2	0.2	0.1
Medication: Ramipril	2.0	2.6	5.7	-2.4	1.4	-1.2	1.6	-1.1
Medication: Simvastatin	1.0	1.5	3.3	-1.3	-0.2	-1.8	-1.2	0.9
Fluid intelligence score	0.9	1.9	5.9	-1.8	0.5	-2.4	-0.1	0.2
Illnesses of siblings	0.2	0.3	0.9	-0.2	0.5	0.4	0.5	-0.9
Neuroticism score	1.5	3.1	5.3	-2.0	-0.5	-2.3	-2.0	1.4
Weight	0.9	4.4	7.4	2.5	0.6	1.4	-2.7	-2.5
Impedance of arm (right)	0.1	0.7	1.6	0.1	0.8	1.3	0.2	-1.0
Arm fat percentage (right)	1.8	7.2	15.8	4.0	1.6	3.7	-1.6	-1.0
Trunk fat-free mass	0.5	3.0	6.3	-0.9	-0.8	-2.1	-1.6	-2.5
Hip circumference	0.4	1.6	4.3	1.1	0.5	0.7	-1.2	-2.1
Time employed in main current job	0.7	0.8	1.4	-1.2	-0.8	-1.1	-0.4	-0.7
Alcohol intake versus 10 years previously	0.8	1.2	1.7	1.1	1.3	1.3	-0.6	-1.0
Father’s age at death	0.5	0.7	1.3	0.3	-0.4	0.9	1.1	-1.1
Worrier / anxious feelings	0.8	1.5	3.1	-1.5	-0.0	-1.8	-0.9	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	3.0	1.2	1.0	0.4	-1.7	1.2
Falls in the last year	1.1	1.5	3.4	1.8	-0.0	1.5	-1.1	-0.7
Hair/balding pattern: Pattern 3	0.5	0.8	1.5	0.1	-1.2	-0.2	-1.2	-0.9
Number of live births	0.2	0.3	0.8	0.3	0.3	0.9	0.4	-0.7
Forced expiratory volume in 1-second (FEV1)	2.3	7.7	19.6	-4.1	-0.8	-4.4	-0.3	-0.9
Pulse rate	0.8	1.3	2.2	1.5	0.7	0.9	-1.0	-1.4
Happiness	0.2	0.3	1.1	0.4	-0.1	0.0	0.1	1.0
Noisy workplace	0.1	0.1	0.3	-0.3	-0.5	-0.1	-0.5	-0.4
Qualifications: A levels/AS levels or equivalent	0.6	1.4	3.2	-1.8	-0.4	-1.5	1.0	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.1	0.2	0.2	0.2	-0.4	0.0	-0.2
Mouth/teeth dental problems: Dentures	3.4	5.7	10.6	3.2	3.1	1.5	-1.0	2.3
Asthma	0.3	0.5	0.7	0.8	-0.7	0.8	0.7	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.6	-0.9	-0.4	-1.2	0.4	0.6
Medication: Cholesterol lowering	0.1	0.2	0.8	-0.1	-0.9	-0.1	-0.2	0.3
Depression (self-reported)	0.5	0.6	2.5	0.5	0.2	-0.3	-0.5	1.6
Medication: Lansoprazole	1.4	1.6	5.7	0.9	-0.1	-0.2	1.3	2.4
Prospective memory result	1.0	1.2	3.7	1.9	-0.3	0.7	0.3	1.3
Lung cancer (father)	1.3	1.5	3.4	1.9	1.2	1.3	-0.9	-0.2
Illnesses of mother	1.0	1.2	4.5	0.2	-1.0	0.3	2.1	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.3	15.2	-3.9	-0.1	-3.6	-1.0	-1.5
Pulse wave Arterial Stiffness index	0.8	1.0	1.9	-0.7	1.2	-0.1	-1.0	-1.4
Impedance of arm (left)	0.1	0.5	1.0	-0.6	1.0	0.5	0.2	-0.9
Arm fat mass (right)	1.4	5.7	11.6	3.4	1.4	2.8	-2.1	-1.7
Trunk predicted mass	0.5	3.0	6.6	-0.8	-0.8	-2.1	-1.6	-2.6
Standing height	0.7	7.1	18.1	-2.2	-0.8	-2.9	-1.9	-4.3
Length of working week for main job	0.5	0.5	1.4	0.3	0.2	-0.8	0.7	1.2
Exposure to tobacco smoke at home	0.7	0.8	2.9	0.8	0.3	-0.1	-1.7	0.5
Breastfed as a baby	0.9	1.1	2.5	-1.6	0.4	-1.1	-0.7	-1.2
Tense / ‘highly strung’	0.6	1.0	1.9	-1.3	-0.2	-1.4	-0.5	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	4.4	-0.2	0.2	-0.4	-2.1	0.9
Hair/balding pattern: Pattern 4	1.8	4.5	8.5	-2.4	-2.9	-0.7	2.7	0.5
Birth weight of first child	1.0	1.9	5.2	-1.6	-0.9	-2.3	-0.8	0.4
Peak expiratory flow (PEF)	1.8	4.1	11.7	-2.7	-0.1	-3.4	1.1	-0.6
Pulse wave reflection index	0.6	0.8	1.6	-0.5	1.1	0.5	0.6	-1.3
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.7	0.0	-0.6	-0.8	0.9	0.5
Loud music exposure frequency	2.0	2.2	4.6	2.1	0.8	1.8	-1.0	-1.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.7	-0.5	0.4	-1.1	-1.3	-0.8
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	1.8	1.2	0.5	1.4	-1.1	-0.0
Blood clot in the leg (DVT)	2.1	2.7	5.9	2.4	1.7	2.1	0.4	-0.1
Medication: Paracetamol	1.1	1.8	3.8	-0.7	-0.5	-1.5	1.5	1.9
Headache pain in last month	0.9	1.6	4.3	-0.6	-0.4	-1.4	1.1	2.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	-0.6	0.5	-0.3	0.1	-0.2
Glaucoma (self-reported)	1.5	1.7	5.3	0.7	0.3	1.7	-0.0	-2.3
Gout (self-reported)	0.7	0.9	2.4	1.0	1.1	-0.1	-0.4	1.5
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.9	0.7	1.3	1.4	-0.2	-0.6
Medication: Amlodipine	0.8	1.1	2.8	0.5	-0.4	1.7	-1.0	-1.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	-0.2	-0.9	-0.5	0.3	-0.8
Birth weight	0.7	1.6	4.5	-0.8	2.1	-1.1	1.2	0.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.8	-0.2	-1.3	-0.1	1.9	1.2
High blood pressure (siblings)	0.6	0.8	2.3	-1.5	-0.0	-1.0	-0.8	0.3
Forced vital capacity (FVC), Best measure	2.6	9.3	20.5	-4.5	-0.0	-4.4	-1.9	-1.8
Body fat percentage	2.1	8.4	18.2	4.3	1.8	3.9	-1.7	-1.4
Leg fat percentage (right)	2.3	8.4	19.9	4.5	1.5	4.3	-0.6	-1.2
Arm fat-free mass (right)	0.3	1.7	3.8	-0.1	-0.4	-1.3	-1.7	-2.0
Exposure to tobacco smoke outside home	4.5	6.0	15.1	3.9	2.0	3.1	-1.0	0.2
Comparative body size at age 10	0.4	1.1	3.1	-0.6	1.8	-0.7	-0.1	1.3
Number of full brothers	0.8	1.0	2.8	1.7	-0.4	1.0	-0.9	-0.7
Worry too long after embarrassment	1.6	2.7	5.7	-1.9	-0.6	-2.4	-1.9	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	5.6	-0.1	0.2	-0.6	-1.3	2.4
Wheeze or whistling in the chest in last year	0.4	0.8	2.1	1.4	-0.4	0.6	-0.9	0.8
Number of children fathered	0.3	0.4	0.5	-0.6	-0.7	-0.7	0.0	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.2	-0.6	-1.3	-0.9	1.5	1.5
Age at first live birth	0.8	1.4	2.9	-1.6	-0.9	-1.7	0.9	-0.3
Pulse wave peak to peak time	0.6	0.8	1.4	0.7	-1.2	-0.0	0.8	1.2
Health satisfaction	0.8	1.0	3.0	1.1	0.7	0.5	-1.7	0.2
Shortness of breath walking on level ground	1.4	1.7	3.8	1.8	-0.2	1.2	0.1	1.9
Qualifications: College or University degree	0.7	2.2	3.3	-1.8	-1.2	-1.7	1.5	-1.2
Eye problems/disorders: None of the above	0.3	0.3	1.6	0.0	-0.1	-0.2	1.3	0.2
Mouth/teeth dental problems: Loose teeth	1.7	2.0	2.8	-1.7	-1.4	-1.6	-0.1	1.7
Emphysema/chronic bronchitis	0.3	0.3	0.7	0.4	0.3	-0.8	-0.7	0.4
Medication for pain relief, constipation, heartburn	0.5	0.8	2.4	0.4	-0.1	1.0	-0.7	-1.5
Neck or shoulder pain in last month	0.9	1.3	2.6	1.4	0.3	1.3	-0.0	1.6
Medication: Blood pressure	0.4	0.8	2.1	1.5	-0.4	1.2	0.3	-0.0
Angina (self-reported)	0.7	0.9	1.8	1.0	0.8	0.9	-0.6	1.4
Migraine (self-reported)	0.3	0.4	1.7	-0.3	-0.5	-0.2	1.3	0.1
Medication: Ibuprofen	1.0	1.3	2.5	-1.1	-0.5	-1.6	0.7	1.3
Medication: Allopurinol	0.3	0.4	1.3	0.7	-0.2	-0.1	1.2	0.5
Medication: Omeprazole	2.3	2.8	5.5	1.5	2.3	1.3	-2.1	-0.3
Medication: Seretide 50 evohaler	1.0	1.1	2.7	1.6	0.0	1.5	-0.2	-0.8
Mean time to correctly identify matches	0.5	0.9	4.0	0.1	-0.5	0.3	0.3	2.0
Heart disease (mother)	0.3	0.4	0.7	-0.9	-0.1	-0.6	-0.5	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.8	-0.8	0.5	-0.9	-0.3	0.9
Whole body fat mass	1.7	6.9	13.7	3.7	1.6	3.0	-2.2	-2.1
Leg fat mass (right)	1.9	7.3	15.5	3.9	1.5	3.4	-1.9	-2.0
Arm predicted mass (right)	0.4	1.9	3.6	-0.2	-0.5	-1.5	-1.9	-1.9
Pulse rate, automated reading	1.4	4.4	10.6	3.3	-0.4	2.8	0.6	-1.8
Alcohol intake frequency.	1.2	2.7	6.2	2.5	0.9	2.2	-1.3	-0.1
Comparative height size at age 10	1.0	5.4	10.6	-2.5	-2.1	-2.2	-0.7	-3.2
Number of full sisters	2.2	2.7	4.2	1.8	0.2	1.5	-1.9	-2.0
Suffer from ‘nerves’	0.2	0.4	1.1	-0.8	0.4	-0.1	-0.1	-1.1
Overall health rating	0.7	1.6	4.5	1.1	0.9	1.0	-2.1	0.7
Chest pain or discomfort	0.5	0.7	1.8	1.2	-0.1	0.2	-0.7	1.3
Had major operations	0.2	0.3	1.0	0.2	0.4	1.0	0.4	-0.0
Age at last live birth	0.3	0.4	0.7	0.5	-0.4	0.8	0.8	-0.5
Family relationship satisfaction	0.2	0.3	0.9	0.2	-0.1	0.1	-0.9	0.8
Leg pain on walking	0.3	0.3	0.9	0.3	0.9	0.6	-0.6	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.9	-1.0	0.8	-0.5	-0.8	-0.8
Commuting to job workplace: Car/motor vehicle	1.8	2.0	4.3	-2.0	-0.4	-2.1	1.0	0.7
Illness, injury, bereavement, stress in last 2 years	2.4	2.9	5.5	-2.3	-1.1	-2.3	1.4	-0.6
Medication: Aspirin	0.1	0.2	0.4	-0.6	0.1	-0.2	-0.6	0.4
Supplements: Vitamin C	0.3	0.4	0.9	0.3	1.0	0.4	-0.5	0.7
Knee pain experienced in last month	0.6	0.9	2.6	-0.4	0.1	-1.6	0.1	1.4
Hypertension (Self-reported)	0.1	0.4	1.1	1.1	0.2	0.7	-0.5	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.4	1.5	1.5	1.0	-0.5	0.4
Illnesses of father: Heart disease	0.5	0.7	1.3	-0.9	-0.3	-0.3	-1.1	1.1
Illnesses of siblings: Diabetes	1.6	2.0	3.9	2.0	1.3	1.2	-1.3	1.1
Smoking status: Previous	1.4	2.1	4.3	1.9	1.0	2.1	0.9	0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.8	12.4	0.2	0.4	0.4	-2.5	-3.5
Whole body fat-free mass	0.5	2.9	6.7	-0.3	-0.7	-1.6	-2.1	-2.6
Leg fat-free mass (right)	0.5	2.7	6.0	-0.1	-0.7	-1.1	-2.5	-2.4
Arm fat percentage (left)	1.7	6.9	14.6	3.8	1.6	3.6	-1.7	-1.3
Average weekly red wine intake	2.4	3.5	8.5	-1.8	-1.3	-2.0	2.9	0.4
Handedness (chirality/laterality): Left-handed	1.3	1.5	3.5	1.1	-0.2	1.7	-1.9	-0.2
Mood swings	0.3	0.5	2.2	-0.1	0.6	0.0	-1.5	-0.1
Loneliness, isolation	0.9	1.3	2.3	-1.1	-1.5	-1.5	-0.7	-0.2
Long-standing illness, disability or infirmity	0.5	0.8	1.1	1.0	1.0	1.0	-1.1	0.1
Ever had bowel cancer screening	0.2	0.2	0.5	-0.2	0.6	0.4	-0.0	-0.7
Diabetes diagnosed by doctor	0.9	1.5	6.1	0.3	0.7	-0.4	-2.5	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	4.8	1.9	1.6	2.2	0.0	-0.3
Friendships satisfaction	0.7	0.8	1.7	0.9	1.3	-0.4	-0.6	1.0
Qualifications: nursing, teaching	2.0	3.1	7.1	-2.6	-1.1	-2.7	-0.9	0.1
Commuting to job workplace: Walk	0.1	0.2	0.4	-0.6	0.2	-0.5	-0.2	0.2
Eye problems/disorders: Cataract	2.0	2.3	9.9	-0.3	0.9	-0.9	-3.1	0.5
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.8	-0.1	-0.6	-1.1	-1.7	0.5
Medication for cholesterol	0.5	0.7	2.9	-0.2	-0.5	-0.2	0.7	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.7	-1.6	0.7	-1.4	-1.2	0.5
Back pain experienced in last month	0.7	1.0	1.8	-0.4	-0.1	-1.1	1.3	1.3
Mineral and other dietary supplements	1.2	1.6	3.8	1.7	0.4	1.9	-0.8	-0.9
Breast cancer (self-reported)	0.7	0.9	2.5	0.6	1.6	0.0	-0.3	1.1
Asthma (self-reported)	0.2	0.5	0.9	0.9	-0.7	0.8	0.7	-0.2
Osteoporosis (self-reported)	0.7	0.9	1.3	1.2	1.0	1.1	-0.8	-0.4
Osteoarthritis (self-reported)	0.2	0.3	0.6	0.8	0.8	0.1	-0.6	-0.0
Medication: Aspirin	0.2	0.3	0.5	-0.5	0.4	-0.3	-0.6	0.7
Medication: Gliclazide	0.6	0.7	1.8	0.8	0.3	0.4	-1.4	-0.8
Illnesses of father: None of the above (group 1)	0.8	1.0	2.2	1.5	1.4	0.8	0.5	0.0
Smoking status: Current	0.2	0.3	0.7	-0.7	-0.5	-0.8	-0.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	4.9	10.0	-3.2	-2.0	-3.2	0.8	-0.1
Whole body water mass	0.5	3.0	6.2	-0.4	-0.7	-1.7	-2.3	-2.5
Leg predicted mass (right)	0.5	2.8	6.1	-0.1	-0.7	-1.2	-2.4	-2.5
Arm fat mass (left)	1.3	5.4	10.6	3.2	1.5	2.6	-2.1	-1.8
Number of self-reported non-cancer illnesses	0.2	0.3	0.9	1.0	0.2	0.8	0.4	-0.1
Average weekly champagne plus white wine intake	0.4	0.6	1.9	-0.0	0.8	-0.1	0.6	-1.4
Miserableness	1.9	3.3	8.5	-1.8	-0.5	-2.9	-0.6	2.1
Guilty feelings	1.2	1.8	4.9	-1.4	0.3	-2.2	-0.2	1.5
Wears glasses or contact lenses	1.6	1.9	7.8	-0.7	-1.0	-0.4	2.8	0.0
Ever taken oral contraceptive pill	0.9	1.0	2.2	-0.4	-0.7	-0.8	1.3	1.5
Hearing aid user	0.9	1.0	1.9	-1.1	-1.4	-0.9	-0.5	1.1
Mother’s age at death	1.0	1.2	3.4	0.3	1.2	1.0	-1.8	-0.5
Financial situation satisfaction	0.2	0.3	1.0	0.3	-0.0	0.2	-1.0	-0.6
Tinnitus: Yes, now most or all of the time	0.8	0.9	3.8	-0.2	1.9	-0.7	-0.4	0.3
Commuting to job workplace: Public transport	0.8	0.9	3.3	0.7	0.2	0.5	-1.8	-0.7
Eye problems/disorders: Glaucoma	0.7	0.8	3.1	0.1	-0.0	0.9	-0.1	-1.8
Medication: Blood pressure	0.1	0.2	0.6	-0.2	0.8	-0.4	-0.5	0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.5	1.2	0.1	0.9	0.8	0.0
Supplements: Fish oil (including cod liver oil)	1.7	2.3	5.6	-1.8	0.1	-2.4	1.4	0.7
High cholesterol (Self-reported)	0.1	0.1	0.4	-0.3	0.3	-0.7	0.0	0.3
Medication: Bendroflumethiazide	1.1	1.7	4.4	1.3	0.0	2.1	-0.2	-1.5
Medication: Paracetamol	1.3	2.0	4.0	-1.1	-0.7	-1.6	1.3	2.0
Medication: Lisinopril	0.4	0.6	1.1	1.1	-0.6	0.4	-1.1	-0.2
Medication: Atorvastatin	1.0	1.3	3.8	0.9	0.8	1.1	-0.3	-1.9
Illnesses of father: High blood pressure	0.3	0.3	1.1	-0.5	-1.0	-0.1	0.1	-0.5
Alcohol drinker status: Never	2.6	3.1	7.7	-1.9	-0.4	-2.8	-0.5	2.0
Ever smoked	0.4	0.7	1.7	0.8	0.8	0.3	0.6	1.3
Basal metabolic rate	0.5	2.7	7.3	0.3	-0.3	-0.9	-2.3	-2.7
Leg fat percentage (left)	2.2	8.1	19.7	4.4	1.5	4.2	-0.5	-0.9
Arm fat-free mass (left)	0.4	2.1	5.5	0.2	-0.5	-1.2	-2.3	-1.8
Number of operations (self-reported)	0.2	0.3	1.0	0.4	-0.1	0.7	1.0	0.1
Average weekly beer plus cider intake	1.7	2.4	5.5	1.5	2.4	-0.5	-1.7	1.1
Irritability	1.5	2.5	4.4	-1.5	-1.5	-2.1	-1.3	1.4
Risk taking	1.7	2.6	4.2	1.4	2.0	0.9	-2.0	1.3
Ever had prostate specific antigen (PSA) test	1.8	2.1	4.1	1.3	-0.8	2.0	0.2	-2.0
Fractured/broken bones in last 5 years	2.0	2.6	6.3	1.5	0.7	2.0	-0.2	-2.5
Age started oral contraceptive pill	1.7	2.1	4.0	-2.0	-0.6	-1.8	0.3	1.6
Diastolic blood pressure, automated reading	0.4	1.3	2.6	1.2	0.4	1.0	1.6	-1.1
Ever depressed for a whole week	0.8	1.0	2.3	-1.0	-0.2	-1.5	-0.1	1.2
Unable to work because of sickness or disability	0.5	0.7	1.6	1.3	-0.2	1.3	-0.5	0.1
Commuting to job workplace: Cycle	0.2	0.2	0.5	0.4	0.2	0.4	0.4	0.7
Myopia	4.3	6.3	25.4	0.0	-1.5	1.2	-1.5	-5.0
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	-0.7	0.1	-0.2	0.5	-0.1
Cholesterol lowering medication	0.9	1.3	4.2	0.3	2.0	0.4	-1.1	-0.8
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	4.8	1.8	2.2	1.1	-0.8	0.7
Pain experienced in last month	0.6	1.0	2.9	0.2	-0.8	1.1	-0.5	-1.7
Supplements: Calcium	0.5	0.6	1.3	-0.8	-1.2	-0.6	-0.6	-0.0
Basal cell carcinoma (self-reported)	0.5	0.6	1.3	-1.0	-0.2	0.1	1.1	-1.0
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.0	0.2	0.6	0.2	-1.4	-1.2
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	5.3	2.3	1.6	2.0	0.4	0.3
Heart disease (siblings)	1.1	1.3	2.8	1.7	1.3	0.8	0.8	0.8
Alcohol drinker status: Previous	1.7	2.0	4.0	2.0	1.9	1.4	0.3	-0.4
Pack years of smoking	1.0	1.5	5.8	0.2	0.4	-1.2	0.2	2.4
Impedance of whole body	0.1	0.7	1.6	0.1	1.2	1.3	0.8	-0.3
Leg fat mass (left)	1.8	6.9	15.6	4.0	1.4	3.3	-1.7	-1.8
Arm predicted mass (left)	0.4	2.1	4.7	0.2	-0.4	-1.0	-2.2	-2.1