TWAS hub - AGPS

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.062	0.0290	3.3e-03	0.034	NA	0.008	NA	0.018	0.00370	NA	1.0e-01	NA	2.7e-02
2	GTEx	Nerve Tibial	0.163	0.0672	1.7e-05	0.035	NA	0.061	NA	0.055	0.00150	NA	3.8e-05	NA	8.7e-05
3	GTEx	Ovary	0.215	0.0960	3.1e-03	0.041	NA	-0.012	NA	0.021	0.03600	NA	9.2e-01	NA	1.0e-01
4	GTEx	Testis	0.202	0.0720	1.1e-04	0.055	NA	0.079	NA	0.065	0.00180	NA	2.3e-04	NA	7.7e-04
5	METSIM	Adipose	0.059	0.0230	7.4e-05	0.022	0.027	0.033	0.027	0.042	0.00027	4.9e-05	8.0e-06	5.8e-05	6.6e-07
6	YFS	Blood	0.018	0.0073	4.0e-04	0.007	0.011	0.003	0.012	0.002	0.00190	8.2e-05	2.9e-02	6.5e-05	6.7e-02
7	TCGA	Thyroid Carcinoma	0.068	0.0570	6.0e-03	0.004	0.007	0.002	NA	0.003	0.13000	5.6e-02	1.9e-01	NA	1.6e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Lung FVC	7.2	36.6	83.4	-9.1	-6.6	-5.4	-4.1	-3.1	7.5	-4.2
Forced vital capacity (FVC)	5.7	22.1	38.2	-6.2	-5.6	-4.1	-2.7	-4.4	5.6	-3.1
Forced vital capacity (FVC), Best measure	4.7	17.0	36.5	-5.7	-4.5	-3.1	-1.6	-3.7	6.0	-2.0
Had other major operations	4.1	5.0	9.9	3.1	1.9	2.5	1.4	1.8	-2.5	2.1
Qualifications: nursing, teaching	4.1	6.3	10.1	-2.6	-3.2	-2.7	-2.7	-2.6	1.2	-2.1
Bilateral oophorectomy (both ovaries removed)	3.7	4.3	7.9	-2.8	-2.1	-2.2	-1.5	-1.6	1.5	-2.4
Forced expiratory volume in 1-second (FEV1)	3.6	12.0	23.3	-4.7	-4.2	-2.5	-1.4	-3.0	4.8	-1.9
Sitting height	3.5	24.9	62.3	-4.2	-6.4	-4.9	-3.1	-7.9	2.4	-3.8
Forced expiratory volume in 1-second (FEV1), Best measure	3.5	11.1	28.7	-4.7	-3.6	-2.1	-0.7	-2.8	5.4	-1.2
Breastfed as a baby	3.5	4.3	20.1	-2.8	-1.3	-0.6	0.1	-0.2	4.5	0.1
Peak expiratory flow (PEF)	3.5	8.1	12.5	-2.8	-3.5	-3.0	-2.0	-3.4	2.0	-2.8
Leg fat percentage (right)	3.5	12.6	21.6	4.7	4.4	3.0	2.4	2.7	-4.4	2.4
Leg fat percentage (left)	3.4	12.4	21.3	4.6	4.2	3.0	2.4	2.6	-4.5	2.4
Exposure to tobacco smoke outside home	3.3	4.4	10.1	1.6	2.9	1.9	0.6	3.2	-1.9	1.5
HbA1C	2.8	3.1	5.6	-1.7	-2.4	-1.8	-2.3	-1.8	0.6	-1.1
Illness, injury, bereavement, stress in last 2 years	2.8	3.4	6.9	-1.9	-2.6	-1.4	-1.5	-1.8	1.5	-1.8
Qualifications: None of the above	2.7	5.9	10.2	2.8	3.2	1.9	1.8	3.2	-2.1	1.2
Medication: Ibuprofen	2.7	3.2	7.3	-1.1	-2.1	-2.0	-0.7	-2.7	-0.9	-2.0
Sensitivity / hurt feelings	2.6	4.5	8.4	-2.4	-2.6	-2.3	-2.9	-0.3	1.6	-1.7
Body fat percentage	2.6	10.1	20.8	4.6	3.7	2.7	2.4	2.0	-3.8	2.2
Alcohol intake frequency.	2.6	6.1	14.6	2.5	3.3	2.2	0.7	3.8	-1.9	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.4	5.1	13.4	-3.7	-2.6	-1.3	0.2	-1.7	3.2	-0.8
Ever used hormone-replacement therapy (HRT)	2.3	2.9	5.9	-0.7	-1.9	-2.4	-1.3	-1.8	-0.9	-2.2
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	6.4	2.2	2.5	1.5	1.3	0.2	-1.6	1.0
Handedness (chirality/laterality): Left-handed	2.3	2.8	7.1	1.7	1.3	2.3	1.3	0.7	0.6	2.7
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.5	7.6	1.4	2.8	1.7	0.8	1.4	-0.6	1.3
Blood clot in the leg (DVT)	2.2	2.8	5.5	1.9	1.6	2.4	1.1	0.8	-1.1	2.2
Trunk fat percentage	2.1	8.2	18.2	4.3	3.2	2.4	2.2	1.8	-3.3	2.1
Arm fat percentage (right)	2.1	8.4	16.4	4.0	3.2	2.5	2.5	1.7	-3.4	2.2
Mouth/teeth dental problems: Dentures	2.1	3.5	8.7	1.9	1.7	1.8	0.0	3.0	-2.1	1.4
Loud music exposure frequency	2.1	2.3	5.1	0.6	1.5	2.2	1.8	0.4	-0.1	2.2
Shortness of breath walking on level ground	2.1	2.4	4.5	2.1	1.8	1.4	0.6	0.7	-2.0	1.5
Unable to work because of sickness or disability	2.1	2.8	5.2	0.6	1.7	2.0	1.4	2.3	1.0	2.0
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	5.1	1.9	1.7	2.3	0.9	0.6	-1.3	2.2
Ulcerative Colitis	2.0	2.8	6.0	-0.9	-2.2	-1.6	-2.4	-1.8	0.6	-1.4
Medication: Levothyroxine sodium	2.0	3.4	5.9	1.7	1.9	2.4	1.2	2.0	-0.6	2.4
Alcohol usually taken with meals	2.0	3.2	5.4	-1.2	-1.5	-2.1	-2.1	-2.3	0.3	-2.2
Falls in the last year	2.0	2.7	6.1	1.8	0.2	2.3	1.8	0.7	-0.8	2.5
Prospective memory result	2.0	2.5	5.3	1.7	1.1	2.1	1.0	1.1	-1.2	2.3
Arm fat percentage (left)	2.0	8.1	16.6	4.1	3.3	2.5	2.4	1.4	-3.3	2.1
Supplements: Fish oil (including cod liver oil)	2.0	2.6	6.1	-1.4	-2.5	-2.0	-1.3	-1.0	0.6	-1.7
Mean Putamen Volume	1.9	2.2	4.3	-2.1	-1.8	-1.2	-1.2	-1.4	1.5	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.5	7.6	-1.1	-1.8	-1.5	-0.5	-2.8	-0.5	-1.5
Smoking status: Previous	1.9	2.9	4.5	1.6	2.1	1.9	2.1	1.3	-0.8	1.7
Leg fat mass (left)	1.9	7.2	12.2	3.5	3.0	2.5	2.6	0.7	-3.4	2.2
Diabetes (mother)	1.8	2.3	4.7	0.7	1.6	2.0	1.1	1.3	1.2	2.2
Stomach or abdominal pain in last month	1.8	2.3	7.9	1.7	2.8	1.1	1.0	0.6	-1.3	1.0
Exposure to tobacco smoke at home	1.8	2.0	6.2	-1.0	1.2	1.3	1.6	2.5	0.7	0.8
Age at first live birth	1.8	3.1	7.5	-1.0	-2.0	-2.1	-1.3	-2.7	1.1	-1.5
Leg fat mass (right)	1.8	6.9	11.7	3.4	3.0	2.4	2.4	0.7	-3.3	2.1
Bipolar Disorder (2011)	1.7	1.7	3.4	1.5	1.3	1.1	1.8	0.3	-1.4	0.8
Coronary Artery Disease (CAD)	1.7	2.1	3.8	1.5	1.8	1.2	1.9	1.5	-0.9	0.9
Medication: Ramipril	1.7	2.1	3.6	-1.9	-1.1	-1.2	-1.7	-0.3	1.8	-1.4
Time employed in main current job	1.7	1.9	4.2	-1.7	-1.0	-1.8	-1.2	-0.9	0.3	-2.0
Worry too long after embarrassment	1.7	2.8	8.6	-1.9	-1.8	-1.4	-1.3	-2.9	0.7	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	4.6	-2.1	-1.4	-1.3	-1.7	0.2	1.1	-1.2
Mouth/teeth dental problems	1.6	2.4	7.2	-1.7	-1.1	-1.5	0.2	-0.9	2.7	-1.4
Fluid intelligence score	1.6	3.2	7.3	-1.5	-2.7	-1.6	-1.7	-2.3	0.5	-1.4
Illnesses of mother	1.6	2.0	4.5	1.3	-1.2	-1.0	-0.1	-2.1	-1.9	-1.1
Commuting to job workplace: Car/motor vehicle	1.6	1.8	3.6	-1.8	-1.0	-1.8	-1.1	-0.3	0.2	-1.9
Fractured/broken bones in last 5 years	1.6	2.1	4.3	1.2	1.7	1.8	1.2	0.9	0.6	2.1
Myopia	1.6	2.4	14.7	-0.5	-0.5	-0.9	-0.4	-3.8	-0.0	-0.6
Medication: Blood pressure	1.5	2.7	4.9	1.5	2.0	1.9	2.2	0.3	-0.7	1.7
Ever had prostate specific antigen (PSA) test	1.5	1.7	3.3	1.8	1.6	0.9	1.4	0.5	-1.5	0.8
Ovarian Cancer	1.4	1.8	3.8	-2.0	-1.5	-1.2	-1.4	-0.1	0.9	-1.6
Neuroticism (2016)	1.4	2.0	3.9	-1.7	-1.7	-1.5	-1.3	-2.0	0.7	-0.7
Waist Hip Ratio (WHR)	1.4	6.3	19.0	1.6	3.6	2.5	0.5	4.4	-0.6	1.5
Body mass index (BMI)	1.4	6.0	10.0	3.1	2.5	2.2	2.5	0.7	-3.2	2.2
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	5.2	0.8	1.9	2.3	0.9	2.2	0.3	2.0
Whole body fat mass	1.4	5.7	11.8	3.4	2.4	2.1	2.3	0.4	-3.0	1.9
Pulse rate, automated reading	1.4	4.6	7.2	1.7	1.9	2.6	2.5	-1.6	-1.7	2.7
Comparative height size at age 10	1.4	7.6	28.1	-1.4	-3.6	-2.4	-0.5	-5.3	0.9	-1.9
Neuroticism (Nagel 2018)	1.3	3.1	6.6	-2.6	-2.3	-1.8	-1.6	-1.0	1.0	-1.4
Serious illness, injury or assault to yourself	1.3	1.6	4.1	1.0	1.4	1.7	0.9	0.3	-0.5	2.0
Past tobacco smoking	1.3	2.4	3.5	-1.3	-1.3	-1.9	-1.9	-1.6	0.6	-1.8
Hair/balding pattern: Pattern 2	1.3	1.7	5.3	-1.9	-1.0	-0.6	-0.5	-1.1	2.3	-0.2
Pulse wave Arterial Stiffness index	1.3	1.6	3.3	-1.5	-1.8	-0.6	-0.3	-1.6	1.5	0.1
Trunk predicted mass	1.3	7.2	28.5	-2.5	-3.2	-1.7	-0.2	-5.3	0.8	-1.1
Mineral and other dietary supplements	1.3	1.7	6.5	1.2	2.5	1.3	0.9	0.6	-0.9	0.5
Guilty feelings	1.3	2.0	3.9	-1.5	-2.0	-1.7	-1.4	-0.6	0.6	-1.5
Medication: Omeprazole (e.g. Zanprol)	1.3	1.5	5.5	1.0	1.0	-0.2	-0.7	1.5	-2.3	-0.7
Average weekly spirits intake	1.2	1.5	4.0	-0.8	-1.8	-1.1	-0.4	-2.0	-0.1	-1.2
Ever had hysterectomy (womb removed)	1.2	1.4	2.7	-1.7	-1.1	-1.2	-0.5	-1.5	1.0	-0.9
High blood pressure (mother)	1.2	1.7	4.2	-0.6	0.8	2.1	0.6	1.0	1.4	1.9
Trunk fat mass	1.2	5.2	11.6	3.4	2.3	2.0	2.2	0.3	-2.9	1.7
Number of incorrect matches in round	1.2	2.0	7.6	-1.3	-0.6	0.8	1.0	-0.9	2.8	1.3
Trunk fat-free mass	1.2	7.1	28.4	-2.5	-3.2	-1.6	-0.1	-5.3	0.8	-1.1
Qualifications: A levels/AS levels or equivalent	1.2	2.5	5.1	-2.3	-1.5	-0.8	-0.8	-2.0	2.2	-0.7
Arm fat mass (right)	1.2	4.8	8.6	2.9	2.1	2.0	2.3	0.2	-2.8	1.9
Standing height	1.2	11.7	36.8	-2.8	-4.2	-2.8	-1.2	-6.1	2.4	-2.2
Alcohol drinker status: Never	1.2	1.5	3.4	-1.9	-1.2	-1.1	-1.5	-0.2	0.8	-1.1
Height	1.1	21.1	74.5	-3.2	-5.6	-4.0	-1.0	-8.6	1.6	-3.5
Waist circumference	1.1	4.1	7.0	2.6	2.4	1.8	1.8	0.4	-2.6	1.6
Pulse wave peak to peak time	1.1	1.3	2.8	1.4	1.7	0.5	0.4	1.3	-1.5	-0.1
Neck or shoulder pain in last month	1.1	1.5	3.7	1.4	1.9	0.7	1.5	0.2	-1.2	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.2	-0.0	-1.2	-1.8	-0.9	-0.8	-0.8	-1.7
Miserableness	1.1	2.0	5.7	-2.1	-2.4	-1.1	-1.2	-0.4	0.4	-0.9
Pain type(s) experienced in last month: Hip pain	1.1	1.4	4.0	2.0	0.8	-0.7	0.2	-0.3	-1.9	-0.7
Medication: Paracetamol	1.1	1.7	3.3	-0.7	-1.8	-1.8	-1.3	-1.2	-0.5	-1.3
Age started oral contraceptive pill	1.1	1.4	3.8	-1.4	-1.9	-1.1	-1.1	-0.0	1.0	-0.7
Pain experienced in last month	1.1	1.8	3.5	0.2	0.6	1.9	1.1	0.9	1.7	1.8
Heart disease (siblings)	1.1	1.4	4.8	1.0	1.0	0.5	0.9	1.4	-2.2	0.3
Breast Cancer	1.0	2.4	6.0	0.0	0.3	-1.9	-2.3	0.2	-1.4	-2.4
BMI	1.0	5.5	9.4	3.1	2.3	2.2	2.4	0.8	-2.9	2.1
Vitamin and mineral supplements	1.0	1.4	4.0	1.1	2.0	1.2	1.1	0.9	-1.1	0.1
Multivitamins +/- minerals	1.0	1.3	4.2	-0.9	-2.0	-1.0	-1.3	-0.1	1.2	-0.1
Diabetes (self-reported)	1.0	1.6	3.2	-1.8	-1.4	-0.7	-1.3	-0.1	1.6	-0.9
Medication: Amlodipine	1.0	1.4	3.1	0.9	1.2	1.2	1.8	1.1	0.4	1.3
Illnesses of siblings: Diabetes	1.0	1.2	3.8	1.3	1.3	0.8	0.2	-0.0	-1.9	0.6
Arm fat mass (left)	1.0	4.0	7.1	2.7	1.9	1.8	2.2	-0.0	-2.5	1.7
Worry (Nagel 2018)	0.9	1.9	6.5	-2.6	-0.8	-0.8	-0.4	-1.2	2.0	-0.4
Irritable Bowel Disease (IBD)	0.9	2.1	4.1	-1.5	-1.7	-1.5	-2.0	-0.7	-0.4	-1.6
Reaction Time	0.9	1.7	7.0	0.4	1.3	1.2	0.2	2.6	-0.2	1.2
LDL Cholesterol	0.9	1.4	4.0	-0.0	-0.5	-1.4	-2.0	0.1	-1.1	-1.4
Angina	0.9	1.1	2.5	1.0	1.2	0.5	0.2	1.5	-1.6	0.5
Qualifications: CSEs or equivalent	0.9	1.2	3.4	-1.6	-0.7	0.3	-1.0	0.8	1.8	0.7
Had menopause	0.9	1.1	2.0	-1.2	-1.1	-1.3	-0.8	0.2	0.6	-1.4
Alcohol intake versus 10 years previously	0.9	1.3	3.9	1.1	1.3	1.2	-0.2	2.0	-0.7	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	3.1	-1.3	-1.6	0.3	-0.2	0.5	1.8	1.2
Qualifications: College or University degree	0.9	2.9	7.3	-1.1	-2.2	-1.4	-1.6	-2.7	1.1	-0.9
Whole body fat-free mass	0.9	5.3	24.1	-1.9	-2.7	-1.1	0.4	-4.9	0.6	-0.6
Average weekly red wine intake	0.9	1.4	3.2	-1.2	-1.6	-0.8	-0.2	-1.8	0.8	-0.9
Whole body water mass	0.9	5.4	23.8	-2.0	-2.8	-1.2	0.4	-4.9	0.6	-0.6
Medication: Bendroflumethiazide	0.9	1.4	2.7	1.1	1.6	0.9	1.3	1.2	-1.0	0.8
Medication: Atorvastatin	0.9	1.1	3.8	0.7	1.6	0.6	0.4	1.9	-0.3	0.2
Average weekly beer plus cider intake	0.9	1.2	6.9	-0.1	0.8	0.6	-0.8	2.6	-0.5	-0.0
Alzheimer’s Disease (including proxy)	0.8	1.1	5.2	0.9	2.3	0.9	0.2	0.1	-0.7	0.8
Hypothyroidism (self reported)	0.8	1.9	3.7	0.3	1.5	1.9	0.6	1.9	0.8	1.6
Hearing difficulty/problems: Yes	0.8	1.2	3.6	1.1	-0.5	0.9	-0.1	-1.1	-1.9	1.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.7	0.0	-0.5	1.3	1.0	-0.3	1.1	1.6
Medication for hormone replacement therapy	0.8	0.9	1.9	-1.0	-0.3	-1.4	-0.4	-1.3	0.4	-1.2
Medication: Metformin	0.8	1.2	4.2	-1.2	-0.6	-0.8	-2.1	0.4	0.9	-0.8
Taking other prescription medications	0.8	1.2	2.9	1.2	1.2	0.7	0.2	1.7	-1.2	0.6
Supplements: Glucosamine	0.8	1.1	3.5	-0.3	-1.9	-1.0	-1.0	-0.8	-0.7	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.2	-0.9	-1.0	0.8	0.3	0.3	1.8	1.8
Headache pain in last month	0.8	1.5	3.1	-0.7	-0.8	-1.8	-1.2	-0.2	-1.2	-1.7
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.2	-1.1	-0.7	-0.9	-1.8	0.0	0.1	-1.1
Heart disease (mother)	0.8	1.0	2.6	0.1	0.6	0.9	0.6	1.6	1.5	0.9
Number of full sisters	0.8	0.9	2.7	0.7	0.2	1.5	0.8	0.5	0.5	1.7
Chest pain or discomfort	0.8	1.2	3.9	0.3	0.7	1.5	1.0	0.2	-0.5	2.0
Leg fat-free mass (right)	0.8	4.0	19.9	-1.2	-2.3	-0.5	1.0	-4.5	0.6	-0.1
Diabetes diagnosed by doctor	0.8	1.3	3.1	-1.4	-1.3	-0.6	-1.7	-0.5	1.1	-0.6
Eye problems/disorders: Cataract	0.8	0.9	2.2	-1.5	-1.3	-0.8	-0.2	-1.0	-0.6	-0.6
Leg predicted mass (right)	0.8	4.2	20.3	-1.3	-2.4	-0.6	1.0	-4.5	0.6	-0.2
Irritability	0.8	1.4	4.1	-1.8	-2.0	-0.1	0.1	-1.3	0.9	0.4
Alcohol drinker status: Previous	0.8	0.9	1.9	1.1	1.1	0.9	0.5	1.0	-1.4	0.5
Intelligence (Savage-Jansen 2018)	0.7	2.2	5.2	-0.1	-1.8	-1.2	-1.5	-2.3	-1.5	-1.1
Schizophrenia vs Biploar Disorder	0.7	0.9	1.8	-1.4	-0.8	-0.2	-0.9	1.3	1.1	-0.1
Crohns Disease (2017)	0.7	1.5	2.3	-1.4	-1.4	-1.4	-1.5	-0.3	-0.3	-1.5
HDL Cholesterol	0.7	1.1	4.6	0.5	0.1	-0.0	0.6	-2.1	-1.6	0.2
Respiratory disease	0.7	1.7	4.0	1.4	2.0	1.2	1.5	-0.1	-0.9	1.0
Neuroticism	0.7	1.6	3.0	-1.7	-1.7	-1.4	-1.1	-1.1	-0.1	-1.0
Diabetes (father)	0.7	0.8	1.8	1.3	0.5	1.2	0.6	0.9	0.1	1.0
Severe depression (siblings)	0.7	0.8	2.5	-0.9	-0.4	0.1	-0.9	1.1	1.6	0.3
Townsend deprivation index at recruitment	0.7	1.0	3.1	1.2	-0.0	0.8	-0.4	1.8	-1.1	0.6
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.2	0.3	-0.6	-0.5	-1.1	-1.5	-0.8	-0.6
Impedance of leg (left)	0.7	3.2	9.5	2.2	2.4	0.6	-0.8	3.1	-1.2	0.1
Nervous feelings	0.7	1.3	2.5	-1.4	-0.9	-0.9	-1.0	-1.4	1.6	-0.4
Medication: Simvastatin	0.7	1.0	2.1	-1.5	-0.6	-0.9	-1.3	0.0	0.6	-1.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	2.4	-1.5	-1.4	-0.3	-0.8	-1.5	1.0	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.8	2.4	-0.9	-1.5	0.3	0.1	0.0	1.1	1.2
Medication for pain relief, constipation, heartburn	0.7	1.1	2.4	0.5	0.9	1.3	1.1	0.3	1.2	1.5
Angina (self-reported)	0.7	0.9	2.2	0.8	1.2	0.6	0.1	1.5	-1.2	0.6
Ever taken oral contraceptive pill	0.7	0.7	2.2	0.1	-0.5	-1.2	-1.5	-0.7	-0.3	-0.8
Medication: Lisinopril	0.7	1.0	2.6	-0.3	1.6	1.0	1.1	0.8	0.8	0.7
Number of operations (self-reported)	0.7	1.0	2.2	1.4	0.5	0.4	0.4	-1.5	-1.4	0.5
Risk taking	0.7	1.1	4.0	-0.2	0.1	1.3	0.3	0.7	1.0	2.0
Ulcerative Colitis (UC)	0.6	1.1	2.6	-0.9	-1.4	-0.9	-1.6	-0.9	-0.4	-0.8
Verbal and Numeric Reasoning (VNR)	0.6	1.4	4.5	-0.3	-1.8	-0.7	-0.7	-2.1	-0.8	-0.7
Lung FEV1/FVC ratio	0.6	3.2	6.4	1.7	1.2	2.5	1.8	1.5	-0.1	2.5
Relative age of first facial hair	0.6	1.2	2.5	-0.7	1.3	1.4	0.0	1.1	0.9	1.6
Systolic blood pressure, automated reading	0.6	1.8	6.1	-0.3	1.2	1.1	2.5	0.2	1.2	1.4
Impedance of leg (right)	0.6	2.9	9.6	1.9	2.2	0.2	-1.1	3.1	-0.8	-0.2
Leg fat-free mass (left)	0.6	3.2	16.7	-0.9	-1.8	-0.4	1.1	-4.1	0.4	0.0
Leg predicted mass (left)	0.6	3.3	17.1	-0.9	-1.9	-0.4	1.1	-4.1	0.4	0.0
Financial difficulties in last 2 years	0.6	0.8	1.5	0.2	1.2	1.1	1.1	0.7	0.2	1.2
Neuroticism score	0.6	1.2	3.3	-1.8	-1.4	-0.7	-1.2	-0.5	0.9	-0.1
Tense / ‘highly strung’	0.6	1.1	3.9	-2.0	-0.8	-0.1	-0.1	-0.7	1.5	0.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	3.6	-0.0	-0.5	-0.6	0.2	-1.9	-0.9	-0.4
Medication: Paracetamol	0.6	1.0	1.9	-0.5	-1.4	-1.2	-1.2	-0.8	-0.7	-0.8
High blood pressure (siblings)	0.6	0.8	2.6	-1.6	-0.5	-0.7	-0.0	-0.2	1.4	-0.6
Arm fat-free mass (right)	0.6	2.9	14.9	-1.4	-1.7	-0.7	0.3	-3.9	0.2	-0.4
Medication: Omeprazole	0.6	0.8	2.4	0.6	0.6	-0.3	-0.7	1.1	-1.6	-0.6
Medication: Seretide 50 evohaler	0.6	0.7	1.3	-0.3	0.9	1.0	1.1	-0.5	-0.2	1.1
Mean time to correctly identify matches	0.6	1.2	6.4	0.5	0.7	0.6	0.1	2.5	-0.8	0.5
Arm predicted mass (right)	0.6	3.2	16.0	-1.5	-1.9	-0.8	0.4	-4.0	0.2	-0.4
Overall health rating	0.6	1.4	4.6	0.5	1.9	-0.0	-0.4	2.1	-1.0	-0.2
Leg pain on walking	0.6	0.7	1.9	-0.3	0.9	0.8	1.4	0.5	0.7	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.1	5.6	-0.5	-0.7	-0.7	0.8	-2.4	0.8	-0.0
Back pain experienced in last month	0.6	0.8	2.6	-0.1	-0.8	-0.6	0.2	-1.6	-1.4	-0.5
Osteoporosis (self-reported)	0.6	0.7	2.5	0.3	1.6	0.7	1.0	0.9	-0.1	0.4
Illnesses of father: None of the above (group 1)	0.6	0.8	1.7	0.9	0.8	-1.0	-0.1	0.3	-1.3	-1.0
Number of self-reported non-cancer illnesses	0.6	1.1	3.2	1.0	1.7	0.4	-0.2	-0.6	-1.8	0.1
Financial situation satisfaction	0.6	0.7	2.0	-0.2	0.3	1.3	0.7	0.5	0.7	1.4
Illnesses of father: High blood pressure	0.6	0.7	2.0	-0.6	-0.3	0.9	0.4	0.1	1.4	1.3
Basal metabolic rate	0.6	3.4	17.9	-1.1	-2.0	-0.6	0.7	-4.2	0.1	-0.2
Arm fat-free mass (left)	0.6	3.0	13.6	-1.6	-2.0	-0.6	0.5	-3.7	0.1	-0.2
Arm predicted mass (left)	0.6	3.0	14.2	-1.6	-1.9	-0.7	0.5	-3.8	0.2	-0.2
Alzheimer’s Disease (in mother)	0.5	0.6	2.9	-0.2	1.7	0.4	-0.5	1.0	0.4	-0.1
Crohns Disease (2012)	0.5	0.8	1.6	0.3	-0.7	-1.1	-0.7	-0.7	-1.2	-1.3
Triglycerides	0.5	0.8	3.5	-0.8	-0.4	-0.4	-1.9	1.0	-0.2	-0.7
Type 2 Diabetes (T2D) (2012)	0.5	0.5	2.3	-0.3	0.2	-0.3	0.3	1.5	1.0	-0.3
Blood Red Count	0.5	5.2	11.5	2.9	3.0	1.9	3.4	0.2	-1.1	1.5
Cardiovascular Disease	0.5	1.8	7.1	-2.7	-0.1	0.2	-0.3	0.5	2.2	-0.3
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.3	-1.2	-0.8	-0.8	-1.5	0.1	1.2	-0.8
Hand grip strength (left)	0.5	1.4	4.6	-2.1	-0.3	0.8	0.9	0.4	1.7	0.4
Hand grip strength (right)	0.5	1.4	4.7	-2.2	0.0	0.8	0.3	0.8	1.9	0.2
Relative age voice broke	0.5	0.8	2.9	0.2	1.4	0.7	-0.3	1.7	-0.3	0.2
Age when periods started (menarche)	0.5	1.3	2.8	-0.1	-0.3	-0.9	-1.7	0.5	-1.5	-1.7
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.0	-0.4	-1.7	-0.8	-1.1	-1.6	-0.6	-0.7
Hearing difficulty/problems with background noise	0.5	0.9	2.7	1.3	-0.9	0.3	-0.2	-0.6	-1.6	0.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.7	-1.3	-1.0	0.0	-0.1	0.2	1.1	0.4
Heart attack	0.5	0.6	2.5	0.1	0.8	-0.3	-1.6	0.6	-0.5	-0.6
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.5	-0.3	-0.4	-0.4	-1.6	-0.6	-0.9	-0.4
Weight	0.5	2.4	4.5	1.7	0.5	0.9	1.8	-2.1	-2.0	1.0
Worrier / anxious feelings	0.5	1.0	2.5	-1.6	-0.6	-1.1	-0.6	-0.9	1.1	-0.7
Medication: Lansoprazole	0.5	0.5	2.1	0.8	0.7	0.5	0.4	0.4	-1.4	0.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.4	-0.7	0.4	0.9	1.2	0.1	0.8	0.9
Suffer from ‘nerves’	0.5	0.7	1.4	-0.9	0.7	0.9	0.6	0.4	1.1	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.7	-0.5	0.1	0.3	-0.2	0.9	1.6	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.4	-0.1	-0.1	-0.6	-0.6	0.2	-1.6	-0.8
Medication: Gliclazide	0.5	0.6	2.0	-0.4	-0.3	0.8	-0.6	-0.5	1.4	0.8
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.8	-0.4	-1.0	-1.1	0.1	0.0	0.5	-1.4
Diastolic blood pressure, automated reading	0.5	1.4	4.4	0.6	1.6	1.0	2.1	-0.7	-0.4	1.0
Ever depressed for a whole week	0.5	0.6	1.8	-1.0	-1.3	0.1	-1.0	0.1	0.7	0.2
Heart attack/myocardial infarction (self-reported)	0.5	0.7	3.3	-0.0	0.7	-0.4	-1.8	0.5	-0.5	-0.6
Depressed Affect (Nagel 2018)	0.4	0.8	1.6	-0.8	-1.3	-1.0	-0.7	0.2	-0.9	-1.1
Schizophrenia (2014)	0.4	0.8	1.8	-0.2	0.3	1.0	1.3	1.3	0.6	0.8
Systolic Blood Pressure	0.4	2.0	6.1	-1.0	0.9	1.1	1.6	-0.1	2.5	1.5
Allergy or Eczema	0.4	1.1	2.7	-0.1	-1.5	-1.1	-0.5	-1.6	-0.8	-0.9
Supplements: Zinc	0.4	0.5	2.0	0.3	-1.4	-0.5	0.1	0.0	-0.6	0.7
Average weekly fortified wine intake	0.4	0.4	1.3	0.2	-0.1	-0.6	0.1	-0.7	-1.2	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.2	-0.4	-0.6	0.7	0.5	1.0	0.9	1.1
High blood pressure	0.4	1.0	1.8	-0.7	1.3	1.2	1.3	0.5	0.7	1.0
Pulse rate	0.4	0.7	1.6	-0.6	-0.1	1.1	0.6	-1.3	0.3	1.1
Lung cancer (father)	0.4	0.5	1.1	1.0	0.8	0.2	-0.2	1.0	-0.9	0.0
Birth weight of first child	0.4	0.8	2.2	-1.5	-0.6	-0.4	-0.7	-0.4	1.2	-0.8
Glaucoma (self-reported)	0.4	0.4	1.0	0.8	1.0	0.6	0.7	0.3	-0.6	0.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.4	0.1	-0.0	-1.0	-1.1	-0.5	-0.2	-1.2
Birth weight	0.4	0.8	1.7	-0.6	-0.3	-0.6	-1.0	1.0	1.3	-1.1
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.5	0.9	0.0	-0.3	-0.7	-0.6	-1.2	-0.1
Comparative body size at age 10	0.4	1.2	4.2	-0.2	-0.2	-1.5	0.4	-1.0	-0.8	-2.1
Wheeze or whistling in the chest in last year	0.4	0.7	1.3	0.6	1.0	0.7	0.2	-0.7	-1.1	1.1
Medication: Aspirin	0.4	0.5	1.7	-0.7	0.7	0.2	-0.4	1.3	0.7	-0.2
Friendships satisfaction	0.4	0.5	1.0	-0.9	-1.0	0.2	0.1	0.9	0.6	0.5
Commuting to job workplace: Walk	0.4	0.4	1.1	-0.9	-0.6	-0.2	-0.4	-0.7	1.1	0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.9	-0.8	-0.8	-0.5	-0.6	-1.7	-0.2	-0.1
Breast cancer (self-reported)	0.4	0.5	2.1	0.7	0.3	0.8	-0.2	1.4	-0.3	0.3
Asthma (self-reported)	0.4	0.8	2.3	0.7	1.5	1.0	0.6	-0.5	-0.7	0.8
Medication: Aspirin	0.4	0.5	1.5	-0.8	0.4	-0.0	-0.7	1.2	0.5	-0.6
Pack years of smoking	0.4	0.5	2.0	-0.1	-0.6	-0.4	-0.7	-0.3	-1.4	-0.8
Impedance of whole body	0.4	1.9	6.0	2.0	1.7	0.2	-0.7	2.5	0.0	-0.1
Prostate Cancer	0.3	0.5	2.3	0.3	-0.4	0.5	-0.2	0.5	1.5	0.4
Lupus	0.3	0.5	1.1	0.1	0.8	1.1	0.6	0.4	0.0	0.9
Blood Platelet Count	0.3	3.1	8.9	1.8	2.8	1.3	0.0	3.0	-0.4	0.1
Heel T-Score	0.3	2.3	6.7	-1.4	-2.6	-1.2	-1.6	-0.4	1.9	-0.1
Number of treatments/medications taken	0.3	0.5	0.8	-0.7	-0.9	-0.8	-0.8	-0.2	0.3	-0.9
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.3	-0.5	-1.2	-0.3	0.0	-0.4	1.0	0.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.0	0.4	1.0	0.1	0.3	0.4	-1.0	-0.2
Pack years adult smoking proportion	0.3	0.5	2.1	-0.0	-0.4	-0.3	-0.6	-0.5	-1.5	-0.7
Fed-up feelings	0.3	0.6	1.5	-0.6	-0.2	1.0	0.2	1.2	0.4	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	2.6	0.4	-1.6	-0.2	-1.0	0.5	-0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.8	-0.1	-1.4	-0.1	-0.8	0.7	1.0	0.4
Hip circumference	0.3	1.2	4.5	1.1	0.1	-0.1	0.8	-2.1	-1.3	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.9	-0.7	-0.4	-0.5	-1.0	0.2	-0.5	-0.6
Asthma	0.3	0.7	1.5	0.7	1.2	0.6	0.6	-1.0	-0.7	0.6
Depression (self-reported)	0.3	0.3	1.7	0.4	-0.0	0.5	0.2	0.0	0.1	1.3
Hair/balding pattern: Pattern 4	0.3	0.8	2.4	-0.1	1.0	-0.2	-1.5	1.2	-0.7	-0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.4	0.1	-0.9	-1.2	-0.8	-0.3	0.2	-0.9
Number of full brothers	0.3	0.4	1.0	0.4	0.5	1.0	0.1	0.5	-0.4	0.8
Eye problems/disorders: None of the above	0.3	0.3	0.7	0.6	0.2	0.4	-0.9	0.5	0.8	0.4
Migraine (self-reported)	0.3	0.3	1.2	-0.2	-0.4	-0.9	0.3	0.3	-0.4	-1.1
Knee pain experienced in last month	0.3	0.4	1.2	-0.3	-0.5	-0.5	-1.1	0.6	-0.6	-0.7
Hypertension (Self-reported)	0.3	0.9	1.6	-0.7	1.3	1.0	1.2	0.2	0.8	0.9
Illnesses of father: Heart disease	0.3	0.4	1.3	-0.9	-1.2	0.1	0.1	-0.7	0.1	0.2
Mood swings	0.3	0.5	2.3	0.0	0.2	0.7	-0.3	1.5	0.3	0.7
Loneliness, isolation	0.3	0.4	0.8	-0.5	-0.9	-0.7	-0.9	-0.2	-0.0	-0.5
Eye problems/disorders: Glaucoma	0.3	0.4	0.8	-0.1	0.4	0.6	0.8	0.9	0.5	0.4
Commuting to job workplace: Cycle	0.3	0.4	2.0	-0.1	0.3	0.5	-0.2	1.4	0.6	0.4
Cholesterol lowering medication	0.3	0.4	1.9	-0.4	0.4	-0.2	-0.3	1.4	0.2	-0.6
Supplements: Calcium	0.3	0.3	1.3	-0.8	-0.4	-0.2	0.4	-0.2	1.1	0.4
Bipolar Disorder (2018)	0.2	0.4	1.0	0.8	-0.7	-0.3	0.3	-0.3	-1.0	-0.5
Depression (Nagel 2018)	0.2	0.3	1.3	-0.1	-1.1	-0.3	0.8	0.0	0.0	0.3
Schizophrenia (2018)	0.2	0.3	1.5	-0.5	0.1	0.5	1.2	0.1	0.4	0.4
Fasting Glucose	0.2	0.2	0.5	-0.2	0.7	-0.1	0.3	-0.6	0.5	-0.5
Rheumatoid Arthritis	0.2	0.2	0.8	0.8	0.5	0.1	0.0	-0.0	-0.9	0.3
Blood Eosinophil Count	0.2	1.8	5.3	-1.9	-0.9	-1.1	-0.9	-0.5	2.3	-0.8
Smoking Status	0.2	0.5	2.1	-0.8	-1.5	-0.5	0.0	-0.3	0.4	-0.6
Chronotype (morning person)	0.2	0.4	2.0	-0.1	-0.1	-0.6	-1.4	-0.3	0.7	-0.3
Hair Pigment	0.2	5.1	15.6	0.8	1.5	3.4	2.3	-0.4	-0.2	4.0
Current tobacco smoking	0.2	0.3	1.1	-0.7	-1.1	-0.4	-0.4	-0.0	0.3	-0.6
Medication: Atenolol	0.2	0.2	1.0	0.2	-0.0	-0.3	-0.4	-0.3	-1.0	-0.4
Chronic bronchitis/emphysema (father)	0.2	0.2	0.6	-0.6	-0.4	0.3	-0.4	0.8	-0.1	-0.2
Allergy	0.2	0.4	1.0	-0.4	0.4	-0.5	0.2	1.0	1.0	-0.3
Pain all over the body in last month	0.2	0.2	0.5	0.4	-0.1	0.3	0.6	-0.1	-0.7	0.5
Illnesses of siblings	0.2	0.3	1.0	0.2	-0.7	-0.4	-1.0	0.1	0.3	-0.2
Impedance of arm (right)	0.2	0.7	2.2	1.5	0.8	0.1	-0.1	1.4	0.5	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.9	0.5	-0.3	0.3	0.5	0.9	-0.7	0.8
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	-0.3	0.6	0.4	0.8	-0.5	-0.6	0.6
Medication: Cholesterol lowering	0.2	0.3	0.9	-0.8	0.9	0.7	-0.4	0.4	0.3	0.3
Length of working week for main job	0.2	0.3	0.4	-0.0	0.6	0.6	0.5	-0.7	0.4	0.6
Pulse wave reflection index	0.2	0.3	1.3	-0.1	0.3	-0.2	-0.5	0.5	1.1	-0.2
Number of children fathered	0.2	0.2	0.8	-0.6	-0.2	-0.1	-0.1	0.3	0.9	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	-0.4	-0.7	0.3	0.6	-0.6	0.1	0.3
Emphysema/chronic bronchitis	0.2	0.2	0.4	-0.4	-0.6	-0.2	-0.6	0.1	-0.5	-0.5
Medication: Allopurinol	0.2	0.3	1.5	0.5	0.5	0.5	1.2	0.1	-0.1	0.2
Had major operations	0.2	0.3	0.5	0.7	0.4	0.0	0.7	-0.7	0.1	0.5
Age at last live birth	0.2	0.3	0.6	0.6	0.7	0.2	0.7	-0.8	0.4	0.5
Family relationship satisfaction	0.2	0.2	0.6	-0.0	-0.7	0.2	0.0	0.8	0.6	0.5
Long-standing illness, disability or infirmity	0.2	0.4	0.8	0.5	0.4	0.6	0.2	0.9	-0.5	0.8
Ever had bowel cancer screening	0.2	0.2	0.7	-0.4	0.1	-0.5	-0.3	-0.2	-0.5	-0.8
Medication for cholesterol	0.2	0.3	0.6	0.8	0.5	0.5	-0.0	0.6	-0.5	0.5
Osteoarthritis (self-reported)	0.2	0.2	1.1	0.1	-1.0	0.4	-0.0	0.2	0.0	0.6
Wears glasses or contact lenses	0.2	0.2	0.9	0.2	-0.3	-0.4	0.5	0.2	-0.5	-0.9
Hearing aid user	0.2	0.2	0.7	0.1	-0.2	-0.4	0.2	-0.8	-0.6	-0.1
Mother’s age at death	0.2	0.3	0.9	-0.3	0.7	-0.2	0.4	-0.2	1.0	0.3
Medication: Blood pressure	0.2	0.3	0.8	-0.9	-0.9	-0.5	0.1	0.1	0.3	-0.6
High cholesterol (Self-reported)	0.2	0.4	0.9	-0.8	0.9	-0.1	-0.0	0.9	0.1	-0.8
Ever smoked	0.2	0.4	1.1	0.6	-0.2	0.7	1.0	0.5	-0.6	0.8
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.0	0.8	-0.9	-1.0	-1.0	-0.4	-0.6	-0.9
Bipolar Disorder or Schizophrenia	0.1	0.2	1.3	0.1	-0.3	0.2	1.1	-0.1	-0.3	0.1
Alzheimer’s Disease (in father)	0.1	0.2	0.4	0.6	0.3	-0.2	0.1	-0.5	-0.7	-0.0
Major Depression (MDD)	0.1	0.2	0.4	-0.4	-0.1	0.2	-0.1	0.5	0.6	0.4
Age at First Birth	0.1	0.2	0.6	0.0	-0.0	0.0	0.7	-0.8	0.4	0.1
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	0.3	0.5	0.5	-0.3	0.3	0.2	0.7
Primary Biliary Cirrhosis	0.1	0.2	1.1	-1.1	-0.3	0.2	0.2	-0.2	0.3	0.0
Medication: Co-codamol	0.1	0.1	0.3	-0.2	0.1	0.5	0.2	-0.2	-0.2	0.3
Maternal smoking around birth	0.1	0.1	0.3	-0.2	-0.2	0.6	0.1	0.3	0.4	0.5
Father’s age at death	0.1	0.1	0.2	0.2	-0.0	-0.3	-0.3	-0.4	-0.1	-0.2
Number of live births	0.1	0.2	0.7	0.2	0.4	-0.2	-0.1	0.8	-0.4	-0.3
Happiness	0.1	0.2	0.5	0.4	-0.7	0.2	0.2	-0.5	0.0	0.4
Noisy workplace	0.1	0.1	0.8	-0.0	-0.2	-0.2	0.0	-0.9	-0.3	0.1
Impedance of arm (left)	0.1	0.7	1.7	1.3	0.6	-0.4	-0.7	1.0	0.7	-0.7
Gout (self-reported)	0.1	0.2	0.5	0.3	0.5	0.2	0.7	0.1	-0.5	-0.1
Health satisfaction	0.1	0.1	0.5	-0.2	-0.2	0.4	0.4	-0.1	-0.1	0.7
Supplements: Vitamin C	0.1	0.1	0.4	0.2	0.3	0.2	0.4	0.6	-0.4	0.3
Smoking status: Current	0.1	0.2	1.1	-0.3	-1.0	-0.2	-0.3	0.0	0.1	-0.3
Average weekly champagne plus white wine intake	0.1	0.1	0.4	0.5	-0.2	-0.2	0.0	-0.0	-0.6	-0.6
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.3	0.3	0.2	-0.1	-0.1	-0.5	-0.0
Basal cell carcinoma (self-reported)	0.1	0.1	0.4	-0.1	0.2	-0.4	0.1	-0.5	0.6	-0.3
Blood White Count	0.0	0.3	0.6	0.7	0.3	0.5	0.8	0.0	-0.8	0.5
Tanning	0.0	0.2	0.4	0.6	-0.3	0.0	0.6	-0.5	-0.1	-0.2

Hub : Genes

AGPS

Models

Trait associations