Hub : Genes

TTC30A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.121	0.0360	4.4e-09	0.087	0.089	0.079	NA	0.089	8.9e-11	6.0e-11	7.0e-10	NA	5.4e-11
2	GTEx	Brain Cerebellum	0.130	0.0600	2.1e-03	0.134	NA	0.027	NA	0.141	9.1e-05	NA	5.2e-02	NA	5.8e-05
3	GTEx	Cells EBV-transformed lymphocytes	0.203	0.0840	3.6e-03	0.052	NA	0.084	NA	0.069	8.4e-03	NA	1.1e-03	NA	2.9e-03
4	GTEx	Skin Sun Exposed Lower leg	0.074	0.0330	7.4e-03	0.054	NA	0.009	NA	0.034	3.0e-05	NA	5.6e-02	NA	8.3e-04
5	TCGA	Brain Lower Grade Glioma	0.054	0.0303	9.4e-05	0.033	0.034	0.037	NA	0.030	9.8e-05	7.9e-05	4.1e-05	NA	2.0e-04
6	TCGA	Lung Adenocarcinoma	0.058	0.0356	4.1e-04	0.002	0.013	-0.001	NA	0.005	1.8e-01	1.1e-02	4.3e-01	NA	8.5e-02
7	TCGA	Thyroid Carcinoma	0.052	0.0310	2.6e-03	0.022	0.023	0.027	NA	0.015	3.1e-03	2.6e-03	1.1e-03	NA	1.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.0	1.6	3.4	1.1	1.1	1.6	0.9	0.4	1.8	1.1
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	0.4	0.2	0.6	0.3	-0.1	0.8	0.7
Depressed Affect (Nagel 2018)	0.4	0.8	2.2	-0.9	-1.5	0.6	-0.1	-1.3	-0.2	-0.9
Depression (Nagel 2018)	0.2	0.3	1.4	0.3	-0.0	0.1	-0.7	-1.2	-0.4	0.2
Intelligence (Savage-Jansen 2018)	0.5	1.4	4.8	0.3	-0.4	2.2	1.2	0.6	1.7	0.3
Neuroticism (Nagel 2018)	1.2	2.7	7.8	-2.5	-2.8	0.7	0.3	-1.8	-0.6	-0.8
Schizophrenia (2018)	0.1	0.2	0.4	-0.4	-0.7	-0.5	-0.3	-0.5	-0.5	0.0
Schizophrenia vs Biploar Disorder	1.1	1.4	2.3	-1.5	-1.5	-1.1	-0.7	-1.0	-1.4	-0.8
Worry (Nagel 2018)	1.6	3.4	9.1	-3.0	-2.7	-0.1	0.2	-1.8	-1.5	-1.3
Alzheimer’s Disease (in mother)	0.6	0.7	1.9	-0.8	-0.8	-1.4	-0.7	0.2	-0.8	-0.9
Alzheimer’s Disease (in father)	0.4	0.4	2.4	0.1	-0.2	-0.4	0.2	1.6	0.4	0.4
Alzheimer’s Disease (including proxy)	0.6	0.9	3.9	0.2	0.6	-2.0	-0.3	1.3	-0.7	-0.2
Crohns Disease (2017)	0.4	0.8	2.6	-0.8	-1.1	1.6	0.7	-0.3	0.8	0.1
Irritable Bowel Disease (IBD)	0.5	1.2	2.5	-1.4	-1.5	1.1	-0.0	-1.6	0.5	-0.7
Ulcerative Colitis (UC)	0.6	1.2	2.4	-1.3	-1.5	0.5	-0.6	-1.6	0.0	-1.2
Major Depression (MDD)	1.0	1.2	2.1	-0.8	-0.6	-0.9	-1.3	-1.4	-1.2	-1.1
Reaction Time	0.7	1.4	4.5	-0.5	0.3	-2.1	-1.1	-1.2	-1.3	-0.8
Verbal and Numeric Reasoning (VNR)	0.5	1.3	5.4	0.0	-0.7	2.3	0.3	0.7	1.6	-0.3
Breast Cancer	0.2	0.4	1.0	-0.2	-0.5	0.5	1.0	0.6	0.8	0.2
Ovarian Cancer	1.0	1.3	2.8	-1.7	-1.5	0.8	-0.1	-0.7	-0.0	-1.6
Prostate Cancer	0.2	0.3	1.2	0.3	-0.2	0.1	0.3	1.1	0.0	0.7
Age at First Birth	0.5	0.7	2.1	-0.1	0.5	-0.9	-1.5	0.1	-0.7	-1.2
Bipolar Disorder (2011)	1.1	1.0	3.2	1.6	1.8	0.3	-0.9	0.6	0.5	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	0.5	0.8	-0.4	-0.6	-0.2	-0.1	-0.4
Coronary Artery Disease (CAD)	1.5	1.8	3.7	1.5	1.7	0.1	1.0	1.9	0.5	1.5
Crohns Disease (2012)	1.4	2.3	5.3	0.6	-0.5	2.3	1.6	1.4	2.0	1.3
Mean Putamen Volume	2.2	2.5	4.1	-2.0	-1.7	-0.1	-1.5	-1.6	-1.3	-2.0
Fasting Glucose	0.1	0.1	0.2	0.0	0.3	-0.4	-0.2	-0.5	0.0	0.2
HbA1C	2.3	2.6	7.2	-0.8	-0.8	2.1	2.7	0.0	1.5	1.7
HDL Cholesterol	0.3	0.5	1.1	0.4	0.0	0.6	1.1	0.8	0.7	0.7
LDL Cholesterol	0.3	0.5	1.1	-0.3	-0.3	1.0	0.8	0.4	1.0	0.6
Lupus	0.7	1.1	5.4	-0.0	0.4	-2.3	-0.5	-0.5	-1.3	-0.1
Neuroticism (2016)	0.7	1.1	2.4	-1.3	-1.5	1.0	1.4	-0.6	0.2	0.0
Primary Biliary Cirrhosis	0.6	0.9	2.7	-1.5	-1.6	-0.6	-0.1	-0.5	-0.9	-0.1
Rheumatoid Arthritis	0.4	0.5	1.6	0.5	0.9	-0.4	0.7	-0.5	0.2	1.3
Schizophrenia (2014)	0.1	0.3	0.7	-0.2	-0.5	-0.5	-0.8	-0.7	-0.5	-0.3
Triglycerides	0.4	0.6	2.1	-0.6	-0.5	0.1	1.5	0.4	0.6	1.2
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.2	-0.4	-1.1	0.0	-0.6	-0.2	-0.7	-1.1
Ulcerative Colitis	0.6	0.9	2.1	-0.8	-1.4	1.3	-0.0	-1.2	0.7	-0.5
Blood Eosinophil Count	0.1	1.0	2.9	-1.7	-1.6	0.6	0.2	-0.5	-0.5	-0.4
Blood Platelet Count	0.1	1.4	6.5	1.4	0.8	-0.6	0.0	2.5	0.2	0.4
Blood Red Count	0.4	3.6	9.5	3.1	3.1	-0.3	-0.0	2.2	0.5	0.9
Blood White Count	0.1	0.6	3.2	0.9	1.8	0.2	0.1	-0.2	-0.0	0.1
Heel T-Score	0.2	1.7	5.4	-0.6	-1.1	0.5	-2.3	-0.7	-0.6	-2.0
BMI	0.6	3.8	13.0	2.8	3.6	-1.7	0.2	0.9	0.2	1.2
Height	0.4	7.4	25.1	-1.8	-2.8	5.0	1.4	-2.1	3.0	-0.3
Waist Hip Ratio (WHR)	0.4	1.9	7.2	1.0	1.7	-2.7	0.1	1.0	-1.0	0.4
Systolic Blood Pressure	0.8	3.8	8.7	-1.2	0.1	-2.5	-2.2	-1.8	-3.0	-1.5
Smoking Status	0.3	0.6	1.8	-0.2	0.6	1.1	1.3	-0.8	0.5	0.5
Allergy or Eczema	0.2	0.5	1.9	-0.1	-0.3	1.1	1.4	-0.2	0.7	0.3
Cardiovascular Disease	0.8	2.8	6.4	-2.5	-1.8	-0.9	-0.6	-2.1	-1.7	-1.2
Hypothyroidism (self reported)	0.3	0.6	1.7	0.1	0.2	-1.3	-1.0	0.8	-0.9	-0.2
Respiratory disease	0.2	0.4	0.8	0.9	0.6	-0.9	0.2	0.7	-0.4	0.2
Type 2 Diabetes (T2D) (2018)	0.7	1.2	2.2	-1.2	-1.5	-0.0	-1.0	-1.5	-0.5	-1.2
Lung FEV1/FVC ratio	0.6	2.8	5.1	1.5	2.2	-2.1	-1.8	1.1	-1.5	-0.8
Lung FVC	5.4	27.5	79.4	-8.9	-7.7	1.0	-0.7	-6.0	-2.8	-2.9
Neuroticism	0.7	1.6	4.7	-1.8	-2.2	1.0	1.0	-1.2	0.2	-0.1
Chronotype (morning person)	0.2	0.4	0.8	0.4	0.5	0.9	0.9	-0.0	0.6	0.4
Hair Pigment	0.1	3.7	11.3	0.6	2.2	-3.4	-1.4	-0.7	-2.6	-0.7
Tanning	0.0	0.6	1.4	0.8	0.6	0.2	0.5	1.2	0.5	1.0
Hand grip strength (left)	0.9	2.3	5.4	-2.3	-1.9	-0.2	0.2	-2.3	-0.7	-1.0
Number of treatments/medications taken	0.1	0.2	0.6	-0.5	0.0	-0.3	-0.3	-0.7	-0.7	-0.1
Average weekly spirits intake	0.5	0.6	1.8	-0.9	-1.3	0.4	-0.7	0.6	0.0	-0.8
Sensitivity / hurt feelings	1.3	2.3	4.8	-2.1	-2.2	1.1	0.9	-2.2	0.1	0.3
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.0	-0.3	-0.3	-1.2	-1.7	-1.4	-1.5	-0.8
Hearing difficulty/problems: Yes	0.9	1.3	4.7	1.6	2.2	-0.9	-0.9	0.4	-0.2	0.3
Relative age of first facial hair	1.8	3.8	8.3	-1.4	0.1	-2.9	-1.8	-1.3	-2.4	-2.4
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.3	-0.0	0.3	-1.2	-1.3	-0.8	-1.5	-0.4
Ever used hormone-replacement therapy (HRT)	2.8	3.5	7.6	0.3	0.1	2.8	2.7	-0.3	2.3	2.1
Ever had hysterectomy (womb removed)	0.6	0.7	2.2	-1.5	-1.1	0.4	0.2	-0.8	-0.3	-0.5
Systolic blood pressure, automated reading	0.6	1.7	4.0	-0.6	0.7	-1.4	-1.6	-1.0	-2.0	-1.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.6	0.4	-0.2	0.4	0.4	1.3	0.7	-0.0
Angina	0.6	0.8	1.7	0.7	0.6	-1.3	-1.3	-0.2	-0.9	-0.8
Medication for hormone replacement therapy	0.8	0.9	1.9	-0.9	-0.8	1.2	1.4	-0.6	0.5	0.8
Vitamin and mineral supplements	0.4	0.6	2.0	0.9	-0.0	-0.1	0.6	1.4	0.8	0.5
Supplements: Zinc	0.5	0.6	2.3	1.0	1.5	-0.4	-0.4	-0.6	-0.3	0.3
Medication: Co-codamol	0.1	0.1	0.2	-0.4	-0.2	-0.4	0.1	-0.3	-0.2	0.1
Medication: Metformin	1.7	2.4	4.0	-1.6	-1.9	-0.7	-1.7	-1.2	-1.4	-2.0
Diabetes (father)	0.5	0.6	1.1	0.9	1.0	-0.7	-0.8	1.0	-0.1	-0.1
Diabetes (mother)	1.6	2.1	4.4	-0.1	0.7	-2.1	-1.8	-0.4	-2.1	-1.3
Severe depression (siblings)	1.9	2.2	3.5	-1.3	-1.3	-1.4	-1.9	-0.5	-1.9	-1.6
Pack years adult smoking proportion	0.5	0.8	2.2	0.2	-0.9	1.5	1.1	0.3	0.8	0.7
Impedance of leg (right)	0.4	2.1	4.6	1.8	0.3	0.9	1.5	2.1	1.4	1.3
Leg fat-free mass (left)	0.2	0.9	4.9	-1.0	0.0	0.5	0.1	-2.2	0.1	-0.3
Trunk fat percentage	1.7	6.8	18.9	4.2	4.3	-0.3	1.3	1.8	1.6	1.9
Hand grip strength (right)	1.0	2.8	7.1	-2.7	-2.1	-0.8	-0.4	-1.8	-1.2	-1.6
Townsend deprivation index at recruitment	0.3	0.4	1.3	1.2	0.7	0.2	0.5	-0.6	0.6	0.5
Current tobacco smoking	0.7	1.1	3.2	0.3	0.0	1.8	1.6	0.1	0.9	1.0
Average weekly fortified wine intake	0.4	0.5	1.0	0.3	-0.4	0.5	0.7	1.0	0.7	0.8
Maternal smoking around birth	0.9	1.3	3.6	-0.2	-0.2	-1.0	-1.9	-0.1	-1.1	-1.8
Fed-up feelings	1.6	2.8	8.1	-1.1	-0.8	-1.7	-1.0	-2.8	-2.0	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.9	-0.4	-0.4	-0.8	-1.4	-1.4	-1.7	-1.2
Relative age voice broke	0.3	0.4	1.0	-0.1	0.1	-1.0	-0.5	0.4	-0.6	-1.0
Taking other prescription medications	0.2	0.4	0.6	0.8	0.6	-0.7	-0.2	0.7	-0.5	-0.2
Age when periods started (menarche)	0.3	0.8	2.7	-0.5	-0.9	0.0	0.7	1.7	0.6	0.8
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	4.7	-2.1	-2.2	1.3	0.6	-0.5	0.3	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.2	1.5	0.6	1.8	-0.3	0.4	1.7	0.1
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	4.5	0.5	-0.0	0.7	1.0	2.1	0.5	0.6
Qualifications: CSEs or equivalent	5.9	7.7	13.6	-2.3	-1.8	-2.3	-3.2	-2.6	-3.1	-3.7
Serious illness, injury or assault to yourself	1.1	1.3	3.6	0.9	1.4	-1.9	-1.1	-0.4	-1.2	-0.2
High blood pressure	0.5	1.4	3.3	-0.7	0.9	-1.5	-0.9	-0.9	-1.8	-1.2
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.6	-0.5	-0.6	0.6	1.9	0.1	0.5	0.9
Multivitamins +/- minerals	0.4	0.5	1.4	-0.5	-0.4	0.6	-0.8	-1.2	-0.3	-0.7
Stomach or abdominal pain in last month	1.7	2.1	6.0	1.7	2.5	-1.5	0.5	1.4	-0.5	1.0
Supplements: Glucosamine	1.2	1.6	3.5	0.6	0.2	1.9	1.6	0.4	1.8	1.2
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	3.8	1.9	1.2	0.8	1.5	1.5	1.3	1.3
Medication: Atenolol	1.3	1.6	3.3	-0.5	0.1	-1.4	-1.8	-1.0	-1.4	-1.6
Medication: Levothyroxine sodium	0.8	1.3	2.6	1.4	1.6	-1.6	-0.7	1.0	-0.7	0.5
Sitting height	1.3	9.2	19.4	-3.3	-3.8	4.4	0.9	-3.8	1.8	-0.8
Chronic bronchitis/emphysema (father)	0.3	0.3	1.3	-0.3	-0.4	-0.2	1.1	-0.7	0.1	0.6
High blood pressure (mother)	3.4	4.7	13.2	-1.6	-0.1	-3.6	-2.0	-1.5	-2.9	-1.7
Body mass index (BMI)	1.0	4.4	15.4	2.9	3.9	-1.0	1.1	1.0	0.6	1.7
Impedance of leg (left)	0.6	3.0	5.6	2.2	0.9	0.7	1.8	2.4	1.7	1.8
Leg predicted mass (left)	0.2	1.0	5.2	-1.1	-0.1	0.5	0.0	-2.3	0.1	-0.4
Trunk fat mass	1.2	5.1	14.2	3.4	3.8	0.1	1.6	1.1	1.7	1.9
Waist circumference	1.2	4.3	12.0	2.5	3.5	-0.5	1.9	0.8	1.3	2.5
Number of incorrect matches in round	2.3	3.8	7.4	-1.4	0.1	-2.5	-1.6	-2.7	-2.7	-1.1
Past tobacco smoking	0.7	1.3	5.0	-0.8	-2.2	1.2	-0.5	0.9	0.7	0.0
Alcohol usually taken with meals	0.4	0.6	1.2	-0.8	-0.5	1.0	0.8	-0.4	1.1	0.5
Nervous feelings	0.8	1.4	6.1	-1.6	-2.5	0.7	0.4	-0.4	-0.3	-0.7
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.5	11.6	-1.1	-1.1	-0.6	-1.8	-3.4	-2.0	-1.6
Hearing difficulty/problems with background noise	1.3	2.0	6.9	2.0	2.6	-0.1	0.1	0.6	0.8	1.4
Hair/balding pattern: Pattern 2	2.8	3.6	5.7	-2.3	-1.4	-1.7	-1.7	-1.6	-2.4	-1.9
Had menopause	0.8	1.0	2.4	-1.0	-1.3	1.0	-0.2	-1.5	0.3	-1.0
Had other major operations	3.7	4.5	12.6	3.5	3.2	-0.3	0.4	2.0	1.2	1.7
Forced vital capacity (FVC)	4.1	15.9	37.5	-6.1	-5.8	2.1	-0.3	-5.4	-0.9	-2.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.4	0.6	0.5	0.5	-1.6	-0.6	0.0	-0.7
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	6.0	-2.0	-2.5	-0.5	-0.9	-2.0	-1.6	-1.4
Qualifications: None of the above	2.1	4.5	8.6	2.9	2.9	-0.8	1.0	2.8	1.1	2.0
Financial difficulties in last 2 years	0.4	0.5	1.2	0.5	1.0	-0.7	0.7	0.1	-0.1	1.1
Mouth/teeth dental problems	1.5	2.3	4.1	-2.0	-2.0	0.6	-1.4	-1.3	-0.4	-1.9
Heart attack	0.2	0.2	0.7	-0.3	0.1	-0.2	0.0	-0.9	-0.3	-0.6
Allergy	0.1	0.2	0.8	0.3	0.4	0.4	-0.9	0.2	0.5	-0.1
Pain all over the body in last month	0.3	0.4	1.6	0.0	0.6	-0.3	0.3	-1.2	-0.5	-0.4
Diabetes (self-reported)	1.0	1.5	2.7	-1.6	-1.6	-0.0	-1.0	-1.0	-1.1	-1.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.1	-0.7	-0.9	0.3	1.4	-0.1	0.6	0.4
Medication: Ramipril	1.1	1.4	3.6	-1.1	-0.9	0.9	1.9	0.2	1.0	1.6
Medication: Simvastatin	0.6	0.9	3.0	-1.7	-1.7	0.2	0.4	-0.6	-0.3	-0.2
Fluid intelligence score	1.1	2.3	5.9	-1.5	-2.4	2.1	-0.2	-0.9	1.0	-1.2
Illnesses of siblings	1.9	2.6	6.2	0.6	0.5	1.2	2.1	1.6	1.8	2.5
Neuroticism score	1.4	2.9	7.3	-2.2	-2.7	0.2	-0.0	-2.5	-1.0	-1.0
Weight	0.4	2.1	5.5	1.7	2.3	0.7	1.4	-0.5	1.4	1.3
Impedance of arm (right)	0.1	0.5	1.6	1.3	-0.2	0.6	-0.8	0.8	0.5	-0.4
Arm fat percentage (right)	1.8	7.0	21.7	4.0	4.7	-0.8	1.2	1.7	1.2	2.0
Trunk fat-free mass	0.5	2.9	6.9	-2.4	-1.6	1.7	1.4	-2.6	0.8	0.2
Hip circumference	0.8	3.3	5.1	1.6	2.2	1.3	2.1	-0.2	2.0	2.2
Time employed in main current job	1.1	1.3	3.9	-1.9	-2.0	0.4	0.8	-0.2	0.1	-0.6
Alcohol intake versus 10 years previously	0.8	1.3	2.7	1.0	1.6	-0.8	1.5	0.6	0.5	1.3
Father’s age at death	0.0	0.1	0.2	0.0	0.2	-0.1	-0.3	0.2	0.1	-0.4
Worrier / anxious feelings	0.8	1.5	4.2	-2.0	-2.0	0.4	0.9	-1.0	-0.7	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.0	0.9	0.7	-0.1	-1.4	-1.2	-0.6	-0.8
Falls in the last year	0.9	1.2	3.8	1.7	1.9	-0.8	0.5	-0.3	0.2	0.8
Hair/balding pattern: Pattern 3	0.4	0.6	1.4	-0.6	-0.5	0.1	0.9	-1.0	0.6	1.2
Number of live births	0.9	1.3	3.2	0.7	0.5	0.5	1.8	1.5	0.8	1.5
Forced expiratory volume in 1-second (FEV1)	3.1	10.5	23.9	-4.9	-4.5	1.2	-1.0	-4.4	-1.2	-2.4
Pulse rate	0.4	0.7	1.6	-0.4	0.4	-0.7	-1.0	-0.1	-1.1	-1.2
Happiness	0.5	0.7	1.6	0.0	-1.3	0.8	-0.8	-0.3	-0.3	-1.2
Noisy workplace	0.4	0.5	1.5	0.1	0.0	-0.7	0.6	1.2	-0.2	1.0
Qualifications: A levels/AS levels or equivalent	1.4	3.1	6.0	-2.4	-1.5	-1.4	-1.6	-1.8	-1.9	-1.2
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	5.2	-1.3	-1.2	-1.4	-2.3	-1.0	-1.5	-1.9
Mouth/teeth dental problems: Dentures	1.4	2.3	6.2	2.2	2.5	-0.7	0.9	1.1	0.4	1.6
Asthma	0.1	0.2	0.4	0.5	0.5	-0.6	0.6	0.4	-0.3	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.8	-0.9	-1.3	1.1	1.2	0.4	0.7	1.0
Medication: Cholesterol lowering	0.9	1.3	3.9	-1.5	-0.7	-2.0	-0.4	-0.2	-1.6	-0.3
Depression (self-reported)	1.0	1.2	2.7	0.0	-0.3	-1.1	-1.5	-1.6	-1.2	-0.9
Medication: Lansoprazole	0.5	0.5	3.4	0.3	-0.1	-0.1	0.2	1.8	-0.0	0.4
Prospective memory result	0.7	0.9	1.9	1.4	1.2	-0.8	-0.3	1.4	-0.3	0.4
Lung cancer (father)	0.1	0.1	0.4	0.4	0.1	-0.7	0.2	0.1	-0.0	0.4
Illnesses of mother	6.7	8.3	13.8	2.4	0.8	3.7	3.0	2.8	3.7	2.7
Forced expiratory volume in 1-second (FEV1), Best measure	3.3	10.7	24.8	-5.0	-4.3	0.4	-1.1	-4.6	-2.1	-2.2
Pulse wave Arterial Stiffness index	0.9	1.0	2.6	-1.6	-1.1	-0.1	-0.5	-1.6	-0.5	-0.6
Impedance of arm (left)	0.2	1.1	1.8	1.2	-0.8	1.3	-0.9	1.3	0.9	-0.7
Arm fat mass (right)	1.2	4.9	15.5	3.0	3.9	-0.3	1.6	0.7	1.4	2.1
Trunk predicted mass	0.5	2.9	6.9	-2.4	-1.6	1.7	1.3	-2.6	0.7	0.2
Standing height	0.6	6.1	12.6	-2.5	-3.2	3.5	0.9	-3.0	1.8	-0.6
Length of working week for main job	0.2	0.2	0.5	-0.0	0.3	-0.2	-0.7	-0.2	-0.5	-0.6
Exposure to tobacco smoke at home	0.6	0.7	1.5	-1.0	-0.2	-1.2	-0.1	-0.8	-1.1	-0.6
Breastfed as a baby	3.7	4.6	7.2	-2.7	-1.9	-1.3	-2.3	-2.2	-2.5	-1.8
Tense / ‘highly strung’	2.3	3.8	6.9	-2.6	-2.6	-1.2	-1.0	-2.3	-1.9	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.7	5.0	-2.0	-1.4	-1.1	-0.8	-2.2	-2.0	-1.3
Hair/balding pattern: Pattern 4	0.1	0.3	0.8	0.5	0.7	-0.1	-0.9	0.0	-0.5	-0.8
Birth weight of first child	0.4	0.7	1.7	-1.0	-1.3	0.2	-0.7	1.1	-0.2	-0.8
Peak expiratory flow (PEF)	1.6	3.8	9.2	-2.7	-3.0	2.4	0.4	-1.5	0.8	-1.0
Pulse wave reflection index	0.6	0.8	2.2	-1.0	-1.5	-0.4	-0.4	-1.0	-0.4	-0.7
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.1	-1.0	-1.0	-0.0	0.5	-0.0	-0.6	0.1
Loud music exposure frequency	1.5	1.6	4.0	0.3	1.0	-2.0	-0.9	-1.1	-1.8	-1.0
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	4.5	-1.9	-1.9	0.1	-0.5	-2.1	-0.6	-0.8
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	0.4	0.8	-0.2	0.8	0.7	0.2	0.8
Blood clot in the leg (DVT)	1.0	1.3	2.0	1.2	1.1	-1.4	-1.4	-0.4	-1.3	-0.9
Medication: Paracetamol	0.2	0.4	0.9	-0.4	-1.0	0.7	0.5	-0.6	0.0	0.6
Headache pain in last month	0.7	1.3	2.9	-0.3	-0.2	1.3	1.7	-0.4	1.1	1.7
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	4.6	0.3	-0.8	2.1	0.9	-0.0	1.4	-0.3
Glaucoma (self-reported)	0.6	0.7	3.6	1.0	0.5	-0.2	-0.1	1.9	0.2	0.4
Gout (self-reported)	0.6	0.8	2.6	0.1	0.2	0.1	-1.6	-0.6	-0.4	-1.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.3	0.4	0.6	-1.5	-0.8	1.0	-0.9	0.0
Medication: Amlodipine	1.0	1.4	4.2	1.0	2.0	-1.6	-1.0	-0.2	-1.1	0.0
Medication: Ventolin 100micrograms inhaler	1.5	1.9	4.5	0.4	-0.3	2.1	2.1	0.3	1.8	1.1
Birth weight	0.2	0.4	0.9	-0.7	-1.0	0.7	0.7	-0.1	0.4	0.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.8	0.9	0.4	0.2	-0.0	0.3	0.3	0.1
High blood pressure (siblings)	2.6	3.7	6.3	-1.6	-0.9	-1.3	-2.1	-2.5	-2.2	-2.3
Forced vital capacity (FVC), Best measure	3.9	14.3	33.9	-5.8	-5.2	0.9	-0.9	-5.3	-2.0	-2.3
Body fat percentage	2.2	8.7	24.2	4.6	4.9	-0.6	1.6	2.2	1.7	2.4
Leg fat percentage (right)	3.0	10.8	26.6	4.7	5.2	-0.6	2.5	2.6	1.9	3.1
Arm fat-free mass (right)	0.2	1.0	3.3	-1.4	-0.4	1.0	0.9	-1.8	0.5	0.0
Exposure to tobacco smoke outside home	0.5	0.7	2.1	0.4	0.4	-1.5	-0.3	0.6	-1.1	-0.6
Comparative body size at age 10	0.9	2.5	5.2	0.3	-0.1	2.2	2.3	0.9	2.1	1.5
Number of full brothers	0.4	0.5	1.0	0.5	0.5	-1.0	-1.0	0.1	-0.7	-0.8
Worry too long after embarrassment	1.7	2.9	10.7	-2.1	-3.3	1.2	0.3	-1.7	-0.4	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.9	5.2	-1.2	-0.8	-0.4	-1.0	-2.3	-1.8	-1.3
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	0.3	0.8	-0.8	0.8	-0.0	-0.4	0.7
Number of children fathered	0.5	0.6	1.5	-1.1	-1.2	-0.1	-0.1	-0.7	-0.5	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.4	-0.5	-0.3	-0.3	-1.0	-0.7	-0.7	-1.2
Age at first live birth	0.5	0.8	3.0	-0.5	-0.9	1.7	0.4	0.2	1.1	0.4
Pulse wave peak to peak time	0.8	1.0	2.5	1.6	1.1	0.4	0.6	1.4	0.7	0.6
Health satisfaction	0.3	0.4	1.8	-0.6	-0.3	-0.8	0.2	-0.4	-1.3	0.0
Shortness of breath walking on level ground	1.7	2.1	4.3	2.1	1.6	-1.2	0.4	1.8	-0.1	1.6
Qualifications: College or University degree	0.2	0.6	2.0	-0.5	-1.1	1.4	-0.4	-0.3	0.8	-0.2
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.3	0.1	-0.1	-0.4	-0.3	-0.6	-0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.4	-0.6	-0.2	0.2	1.2	-0.8	0.3	0.5
Emphysema/chronic bronchitis	0.5	0.6	1.8	-0.4	-0.9	1.0	0.5	-1.3	0.5	0.3
Medication for pain relief, constipation, heartburn	0.2	0.4	0.7	0.2	0.6	-0.8	-0.9	-0.4	-0.6	-0.7
Neck or shoulder pain in last month	0.8	1.2	2.7	1.4	1.5	-0.8	-0.3	1.7	-0.3	0.6
Medication: Blood pressure	1.1	1.9	4.1	1.3	2.0	-1.8	-1.2	1.5	-1.0	-0.0
Angina (self-reported)	1.1	1.5	3.0	0.2	0.2	-1.7	-1.7	-0.4	-1.5	-1.4
Migraine (self-reported)	0.1	0.1	0.4	-0.2	0.1	0.5	0.6	0.3	0.1	-0.0
Medication: Ibuprofen	1.1	1.3	2.7	-0.6	-1.0	1.2	1.6	0.8	1.1	1.4
Medication: Allopurinol	1.0	1.4	4.9	0.4	0.6	-0.2	-2.2	-0.1	-0.6	-1.9
Medication: Omeprazole	0.2	0.2	0.5	0.6	0.5	-0.3	0.4	0.7	0.1	0.1
Medication: Seretide 50 evohaler	0.8	0.9	1.9	-1.3	-0.8	-1.0	-0.3	0.0	-1.4	-1.0
Mean time to correctly identify matches	0.2	0.4	0.9	0.5	1.0	-0.8	0.5	0.1	0.2	0.8
Heart disease (mother)	1.7	2.1	5.3	-0.2	0.4	-1.2	-2.3	-1.5	-1.5	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	2.8	0.7	0.5	1.3	1.4	1.2	1.7	1.5
Whole body fat mass	1.4	6.0	17.3	3.5	4.2	-0.1	1.8	1.1	1.7	2.3
Leg fat mass (right)	1.6	6.1	18.4	3.3	4.3	-0.6	2.0	1.2	1.4	2.4
Arm predicted mass (right)	0.2	1.2	3.9	-1.5	-0.4	0.9	1.1	-2.0	0.5	0.3
Pulse rate, automated reading	0.6	1.9	8.6	1.6	2.9	-0.7	0.8	1.0	0.0	0.7
Alcohol intake frequency.	1.1	2.5	5.7	2.0	2.4	-1.4	0.7	1.7	0.1	1.5
Comparative height size at age 10	0.5	2.7	9.5	-0.4	-1.1	3.1	1.0	-1.1	2.3	0.9
Number of full sisters	0.6	0.7	1.7	0.7	1.1	-1.0	-0.3	-0.5	-1.3	-0.6
Suffer from ‘nerves’	1.1	1.8	3.0	-1.7	-1.2	-1.6	-0.1	-1.3	-1.7	-0.8
Overall health rating	0.1	0.2	0.4	0.3	0.1	-0.5	-0.4	0.4	-0.6	-0.6
Chest pain or discomfort	0.4	0.6	2.1	-0.1	0.3	-1.4	-0.8	-0.3	-1.2	-0.1
Had major operations	0.6	0.7	1.5	0.9	1.1	-0.7	-0.3	0.8	-0.4	1.2
Age at last live birth	0.3	0.5	1.3	0.7	0.3	-0.7	-0.8	1.2	-0.5	-0.2
Family relationship satisfaction	0.2	0.2	0.9	0.0	0.1	-0.1	0.3	-1.0	-0.6	0.1
Leg pain on walking	0.5	0.6	1.4	-0.7	-0.0	-1.1	0.5	-0.9	-1.2	0.2
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	2.5	-1.1	-0.6	-1.1	-0.8	-1.4	-1.5	-1.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.1	-1.0	-0.9	1.0	0.7	0.3	0.3	0.3
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.7	-1.7	-1.9	1.4	0.8	-0.1	0.4	-0.2
Medication: Aspirin	0.8	1.0	2.0	-0.5	-0.0	-0.9	-1.4	-0.8	-1.2	-1.4
Supplements: Vitamin C	0.3	0.3	0.6	0.1	0.8	-0.7	0.6	-0.5	-0.4	0.6
Knee pain experienced in last month	0.1	0.2	0.6	-0.1	-0.4	0.4	0.4	-0.5	0.2	0.8
Hypertension (Self-reported)	0.4	1.1	2.7	-0.7	0.7	-1.2	-0.6	-0.9	-1.6	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.1	-0.2	-0.3	-0.0	-0.3	-0.3	-0.4
Illnesses of father: Heart disease	0.3	0.5	1.2	-0.7	0.0	-0.4	-0.0	-1.1	-0.9	-0.7
Illnesses of siblings: Diabetes	0.8	1.0	2.6	1.3	1.6	-0.7	0.7	0.1	0.4	1.4
Smoking status: Previous	0.9	1.4	4.9	1.0	2.2	-1.5	0.8	0.5	-0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	2.7	-1.4	-1.6	0.2	-1.2	-1.4	-1.1	-1.6
Whole body fat-free mass	0.3	1.8	6.4	-1.9	-0.8	1.2	0.8	-2.5	0.5	0.0
Leg fat-free mass (right)	0.2	1.2	6.2	-1.3	-0.2	0.5	-0.0	-2.5	0.1	-0.4
Arm fat percentage (left)	1.7	6.6	20.2	4.0	4.5	-0.7	1.0	1.9	1.2	1.8
Average weekly red wine intake	0.5	0.8	2.4	-0.8	-0.4	1.0	0.9	-1.6	0.6	0.5
Handedness (chirality/laterality): Left-handed	1.7	2.0	4.7	1.7	2.2	-1.4	-1.8	-0.3	-0.9	-0.8
Mood swings	0.4	0.7	2.1	-0.1	-0.4	-0.6	-0.6	-1.4	-1.0	-0.9
Loneliness, isolation	0.4	0.6	2.6	-0.7	-1.6	0.6	0.5	-0.1	0.4	0.3
Long-standing illness, disability or infirmity	0.7	1.0	2.6	0.3	0.6	-1.3	-1.6	0.5	-1.2	-0.9
Ever had bowel cancer screening	0.4	0.4	1.5	0.0	-0.1	0.3	1.2	0.5	0.8	0.7
Diabetes diagnosed by doctor	0.7	1.1	1.9	-1.4	-1.3	-0.1	-0.9	-1.0	-1.0	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.7	0.9	1.3	-1.6	0.4	0.7	-0.4	0.7
Friendships satisfaction	0.7	0.9	1.8	-0.9	-1.3	-0.3	-0.9	0.5	-1.2	-0.9
Qualifications: nursing, teaching	1.1	1.7	4.2	-2.0	-2.0	0.9	0.3	-1.7	-0.1	-0.2
Commuting to job workplace: Walk	0.5	0.6	1.4	-1.2	-0.7	-0.6	-0.2	-1.0	-0.7	-0.1
Eye problems/disorders: Cataract	0.9	1.0	2.9	-1.5	-1.1	-0.3	-0.4	-1.7	-0.3	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.1	-0.9	-1.1	0.2	-0.1	-0.2	-0.2	-0.4
Medication for cholesterol	0.4	0.6	1.8	0.4	0.0	-0.8	-1.2	1.3	-0.1	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	4.6	-2.1	-1.7	-0.2	0.6	-1.1	-0.4	0.3
Back pain experienced in last month	0.8	1.2	4.2	0.2	0.3	-0.1	1.2	1.5	0.4	2.0
Mineral and other dietary supplements	0.4	0.5	2.0	0.4	0.1	-1.2	-0.3	1.4	-0.3	-0.2
Breast cancer (self-reported)	0.5	0.6	1.3	1.0	1.2	-0.4	-0.5	1.1	-0.3	-0.3
Asthma (self-reported)	0.1	0.2	0.8	0.4	0.4	-0.9	0.4	0.5	-0.5	0.2
Osteoporosis (self-reported)	0.3	0.3	2.2	0.3	-0.0	-0.2	-0.1	1.5	0.1	-0.1
Osteoarthritis (self-reported)	0.4	0.6	2.0	0.5	0.4	-0.8	-1.4	-0.5	-0.8	-0.3
Medication: Aspirin	0.6	0.8	1.9	-0.5	0.0	-0.9	-1.2	-0.7	-0.9	-1.4
Medication: Gliclazide	1.7	2.0	3.7	-0.9	-0.8	-1.3	-1.9	-0.8	-1.8	-1.6
Illnesses of father: None of the above (group 1)	1.7	2.2	3.7	1.0	-0.1	1.9	1.7	1.2	1.9	1.6
Smoking status: Current	0.6	1.0	3.1	0.4	0.3	1.8	1.4	-0.2	1.0	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.7	5.8	14.3	-3.8	-3.0	-0.3	-1.4	-2.7	-2.0	-2.0
Whole body water mass	0.4	2.0	7.0	-2.0	-0.9	1.2	0.9	-2.6	0.5	0.0
Leg predicted mass (right)	0.2	1.2	6.0	-1.4	-0.3	0.6	-0.0	-2.4	0.1	-0.4
Arm fat mass (left)	0.9	3.7	12.1	2.7	3.5	-0.3	1.4	0.8	1.1	1.7
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	0.5	0.4	-0.4	-0.3	-0.1	-0.3	-0.5
Average weekly champagne plus white wine intake	1.2	1.6	3.8	0.7	0.2	1.0	1.9	0.4	1.5	1.9
Miserableness	1.7	2.9	6.0	-2.2	-2.5	0.0	-0.8	-2.4	-1.0	-1.3
Guilty feelings	0.8	1.2	3.7	-1.2	-1.9	1.3	0.1	-0.7	0.4	-0.7
Wears glasses or contact lenses	0.3	0.4	0.8	-0.0	-0.5	0.8	0.0	-0.8	0.3	-0.9
Ever taken oral contraceptive pill	0.4	0.4	1.0	0.1	-0.3	1.0	-0.4	1.0	0.7	-0.7
Hearing aid user	0.4	0.5	1.4	0.3	0.2	0.9	-0.9	-0.4	-0.1	-1.2
Mother’s age at death	0.8	1.0	2.5	-0.9	-0.5	-1.2	-0.7	-0.5	-1.6	-1.1
Financial situation satisfaction	0.5	0.6	1.6	-0.3	0.0	-1.0	-0.5	-1.0	-1.3	-0.7
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.8	-0.1	-0.7	1.3	0.0	-0.4	0.3	-0.2
Commuting to job workplace: Public transport	0.1	0.2	0.4	-0.3	-0.5	-0.4	-0.1	-0.7	-0.0	-0.3
Eye problems/disorders: Glaucoma	0.4	0.5	0.9	-0.4	-0.5	-0.7	-0.9	0.7	-0.9	-0.8
Medication: Blood pressure	0.3	0.5	1.9	-0.1	0.6	0.3	1.0	-1.4	-0.1	0.3
Pain type(s) experienced in last month: Hip pain	1.8	2.3	5.2	2.3	1.4	1.4	0.4	1.4	1.8	1.2
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.5	-0.9	-1.0	1.5	-0.1	-1.6	0.5	-0.2
High cholesterol (Self-reported)	0.1	0.2	0.6	-0.8	-0.7	-0.3	0.1	-0.2	-0.5	-0.1
Medication: Bendroflumethiazide	0.4	0.7	1.9	1.1	1.4	-0.5	0.1	1.0	-0.1	0.4
Medication: Paracetamol	0.3	0.5	1.7	-0.2	-0.7	1.3	0.5	-0.5	0.5	0.7
Medication: Lisinopril	1.3	1.7	3.6	-0.7	-0.4	-1.8	-1.8	0.0	-1.9	-1.1
Medication: Atorvastatin	0.8	0.9	2.1	0.7	1.2	-1.4	-1.1	-0.6	-0.7	-0.3
Illnesses of father: High blood pressure	2.8	3.5	5.7	-1.0	-0.2	-1.7	-2.4	-2.1	-2.3	-2.2
Alcohol drinker status: Never	1.3	1.6	3.5	-1.9	-1.7	0.3	-0.7	-1.6	-0.6	-1.1
Ever smoked	0.4	0.6	1.4	0.2	1.2	-0.2	1.1	-1.2	-0.1	0.6
Basal metabolic rate	0.2	1.2	4.6	-1.1	-0.1	1.1	1.0	-2.1	0.7	0.3
Leg fat percentage (left)	3.1	11.3	28.0	4.7	5.3	-0.6	2.7	2.5	1.9	3.3
Arm fat-free mass (left)	0.3	1.3	5.4	-1.5	-0.3	0.6	1.0	-2.3	0.3	0.2
Number of operations (self-reported)	1.2	1.8	4.1	1.7	1.4	0.5	0.8	1.2	1.2	2.0
Average weekly beer plus cider intake	0.7	1.1	2.4	-1.0	-1.5	-0.6	-0.9	-1.0	-0.3	-1.4
Irritability	1.0	1.8	4.6	-1.6	-1.9	0.7	-0.3	-2.1	-0.5	-0.9
Risk taking	1.1	1.5	4.9	-0.3	0.9	-2.2	-1.0	-1.1	-1.6	-0.1
Ever had prostate specific antigen (PSA) test	1.1	1.3	4.1	1.4	2.0	-0.9	-0.1	-0.5	0.4	1.2
Fractured/broken bones in last 5 years	0.5	0.6	1.1	0.6	0.8	-0.8	-0.8	-1.1	-0.8	-0.6
Age started oral contraceptive pill	0.8	1.0	2.2	-0.9	-1.4	1.1	-0.4	-1.5	0.3	-0.5
Diastolic blood pressure, automated reading	0.3	0.9	3.8	0.8	2.0	-0.5	-0.6	-0.8	-0.5	-0.2
Ever depressed for a whole week	0.7	0.9	3.7	-1.3	-1.9	0.2	0.1	-0.9	-0.5	-0.1
Unable to work because of sickness or disability	3.0	3.8	8.6	-0.2	0.3	-2.8	-2.9	0.3	-2.5	-2.0
Commuting to job workplace: Cycle	0.5	0.6	1.4	-0.5	-0.0	-1.2	-0.5	-0.7	-0.9	-1.0
Myopia	0.6	0.9	2.5	-1.0	-1.6	0.2	-0.2	-0.8	-0.6	-1.2
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.3	0.7	-0.9	1.1	0.6	1.1	1.5	0.9
Cholesterol lowering medication	0.2	0.3	0.9	-0.2	-0.2	0.8	0.7	-0.9	0.5	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.9	0.8	0.4	-0.2	0.5	1.0	0.3	0.1
Pain experienced in last month	1.0	1.6	4.2	-0.2	0.0	-1.1	-2.0	-0.5	-1.2	-2.0
Supplements: Calcium	0.5	0.6	1.3	-1.1	-1.1	-0.5	0.7	0.1	-0.8	0.3
Basal cell carcinoma (self-reported)	0.8	1.0	2.2	0.2	-0.5	1.3	1.1	1.5	0.9	0.9
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.9	-0.4	-0.0	-0.2	-0.1	-0.9	-0.3	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.1	1.1	1.1	-1.4	-1.2	-0.3	-1.4	-0.7
Heart disease (siblings)	0.3	0.3	0.8	0.9	0.8	0.1	0.2	-0.8	0.2	-0.4
Alcohol drinker status: Previous	0.4	0.5	1.3	0.7	0.5	0.1	0.9	1.1	0.3	0.7
Pack years of smoking	0.7	1.0	2.9	0.3	-0.8	1.7	1.3	0.1	1.0	0.8
Impedance of whole body	0.2	1.2	3.5	1.9	0.2	0.7	-0.1	1.9	0.9	0.2
Leg fat mass (left)	1.7	6.5	19.5	3.4	4.4	-0.6	2.0	1.2	1.4	2.6
Arm predicted mass (left)	0.3	1.3	5.5	-1.4	-0.1	0.8	1.0	-2.3	0.4	0.3