Hub : Genes

TTC30A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.121 0.0360 4.4e-09 0.087 0.089 0.079 NA 0.089 8.9e-11 6.0e-11 7.0e-10 NA 5.4e-11
2 GTEx Brain Cerebellum 0.130 0.0600 2.1e-03 0.134 NA 0.027 NA 0.141 9.1e-05 NA 5.2e-02 NA 5.8e-05
3 GTEx Cells EBV-transformed lymphocytes 0.203 0.0840 3.6e-03 0.052 NA 0.084 NA 0.069 8.4e-03 NA 1.1e-03 NA 2.9e-03
4 GTEx Skin Sun Exposed Lower leg 0.074 0.0330 7.4e-03 0.054 NA 0.009 NA 0.034 3.0e-05 NA 5.6e-02 NA 8.3e-04
5 TCGA Brain Lower Grade Glioma 0.054 0.0303 9.4e-05 0.033 0.034 0.037 NA 0.030 9.8e-05 7.9e-05 4.1e-05 NA 2.0e-04
6 TCGA Lung Adenocarcinoma 0.058 0.0356 4.1e-04 0.002 0.013 -0.001 NA 0.005 1.8e-01 1.1e-02 4.3e-01 NA 8.5e-02
7 TCGA Thyroid Carcinoma 0.052 0.0310 2.6e-03 0.022 0.023 0.027 NA 0.015 3.1e-03 2.6e-03 1.1e-03 NA 1.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 1.0 1.6 3.4 1.1 1.1 1.6 0.9 0.4 1.8 1.1
Bipolar Disorder or Schizophrenia 0.1 0.3 0.6 0.4 0.2 0.6 0.3 -0.1 0.8 0.7
Depressed Affect (Nagel 2018) 0.4 0.8 2.2 -0.9 -1.5 0.6 -0.1 -1.3 -0.2 -0.9
Depression (Nagel 2018) 0.2 0.3 1.4 0.3 -0.0 0.1 -0.7 -1.2 -0.4 0.2
Intelligence (Savage-Jansen 2018) 0.5 1.4 4.8 0.3 -0.4 2.2 1.2 0.6 1.7 0.3
Neuroticism (Nagel 2018) 1.2 2.7 7.8 -2.5 -2.8 0.7 0.3 -1.8 -0.6 -0.8
Schizophrenia (2018) 0.1 0.2 0.4 -0.4 -0.7 -0.5 -0.3 -0.5 -0.5 0.0
Schizophrenia vs Biploar Disorder 1.1 1.4 2.3 -1.5 -1.5 -1.1 -0.7 -1.0 -1.4 -0.8
Worry (Nagel 2018) 1.6 3.4 9.1 -3.0 -2.7 -0.1 0.2 -1.8 -1.5 -1.3
Alzheimer’s Disease (in mother) 0.6 0.7 1.9 -0.8 -0.8 -1.4 -0.7 0.2 -0.8 -0.9
Alzheimer’s Disease (in father) 0.4 0.4 2.4 0.1 -0.2 -0.4 0.2 1.6 0.4 0.4
Alzheimer’s Disease (including proxy) 0.6 0.9 3.9 0.2 0.6 -2.0 -0.3 1.3 -0.7 -0.2
Crohns Disease (2017) 0.4 0.8 2.6 -0.8 -1.1 1.6 0.7 -0.3 0.8 0.1
Irritable Bowel Disease (IBD) 0.5 1.2 2.5 -1.4 -1.5 1.1 -0.0 -1.6 0.5 -0.7
Ulcerative Colitis (UC) 0.6 1.2 2.4 -1.3 -1.5 0.5 -0.6 -1.6 0.0 -1.2
Major Depression (MDD) 1.0 1.2 2.1 -0.8 -0.6 -0.9 -1.3 -1.4 -1.2 -1.1
Reaction Time 0.7 1.4 4.5 -0.5 0.3 -2.1 -1.1 -1.2 -1.3 -0.8
Verbal and Numeric Reasoning (VNR) 0.5 1.3 5.4 0.0 -0.7 2.3 0.3 0.7 1.6 -0.3
Breast Cancer 0.2 0.4 1.0 -0.2 -0.5 0.5 1.0 0.6 0.8 0.2
Ovarian Cancer 1.0 1.3 2.8 -1.7 -1.5 0.8 -0.1 -0.7 -0.0 -1.6
Prostate Cancer 0.2 0.3 1.2 0.3 -0.2 0.1 0.3 1.1 0.0 0.7
Age at First Birth 0.5 0.7 2.1 -0.1 0.5 -0.9 -1.5 0.1 -0.7 -1.2
Bipolar Disorder (2011) 1.1 1.0 3.2 1.6 1.8 0.3 -0.9 0.6 0.5 0.0
Body Mass Index (BMI) (2010) 0.2 0.2 0.6 0.5 0.8 -0.4 -0.6 -0.2 -0.1 -0.4
Coronary Artery Disease (CAD) 1.5 1.8 3.7 1.5 1.7 0.1 1.0 1.9 0.5 1.5
Crohns Disease (2012) 1.4 2.3 5.3 0.6 -0.5 2.3 1.6 1.4 2.0 1.3
Mean Putamen Volume 2.2 2.5 4.1 -2.0 -1.7 -0.1 -1.5 -1.6 -1.3 -2.0
Fasting Glucose 0.1 0.1 0.2 0.0 0.3 -0.4 -0.2 -0.5 0.0 0.2
HbA1C 2.3 2.6 7.2 -0.8 -0.8 2.1 2.7 0.0 1.5 1.7
HDL Cholesterol 0.3 0.5 1.1 0.4 0.0 0.6 1.1 0.8 0.7 0.7
LDL Cholesterol 0.3 0.5 1.1 -0.3 -0.3 1.0 0.8 0.4 1.0 0.6
Lupus 0.7 1.1 5.4 -0.0 0.4 -2.3 -0.5 -0.5 -1.3 -0.1
Neuroticism (2016) 0.7 1.1 2.4 -1.3 -1.5 1.0 1.4 -0.6 0.2 0.0
Primary Biliary Cirrhosis 0.6 0.9 2.7 -1.5 -1.6 -0.6 -0.1 -0.5 -0.9 -0.1
Rheumatoid Arthritis 0.4 0.5 1.6 0.5 0.9 -0.4 0.7 -0.5 0.2 1.3
Schizophrenia (2014) 0.1 0.3 0.7 -0.2 -0.5 -0.5 -0.8 -0.7 -0.5 -0.3
Triglycerides 0.4 0.6 2.1 -0.6 -0.5 0.1 1.5 0.4 0.6 1.2
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.2 -0.4 -1.1 0.0 -0.6 -0.2 -0.7 -1.1
Ulcerative Colitis 0.6 0.9 2.1 -0.8 -1.4 1.3 -0.0 -1.2 0.7 -0.5
Blood Eosinophil Count 0.1 1.0 2.9 -1.7 -1.6 0.6 0.2 -0.5 -0.5 -0.4
Blood Platelet Count 0.1 1.4 6.5 1.4 0.8 -0.6 0.0 2.5 0.2 0.4
Blood Red Count 0.4 3.6 9.5 3.1 3.1 -0.3 -0.0 2.2 0.5 0.9
Blood White Count 0.1 0.6 3.2 0.9 1.8 0.2 0.1 -0.2 -0.0 0.1
Heel T-Score 0.2 1.7 5.4 -0.6 -1.1 0.5 -2.3 -0.7 -0.6 -2.0
BMI 0.6 3.8 13.0 2.8 3.6 -1.7 0.2 0.9 0.2 1.2
Height 0.4 7.4 25.1 -1.8 -2.8 5.0 1.4 -2.1 3.0 -0.3
Waist Hip Ratio (WHR) 0.4 1.9 7.2 1.0 1.7 -2.7 0.1 1.0 -1.0 0.4
Systolic Blood Pressure 0.8 3.8 8.7 -1.2 0.1 -2.5 -2.2 -1.8 -3.0 -1.5
Smoking Status 0.3 0.6 1.8 -0.2 0.6 1.1 1.3 -0.8 0.5 0.5
Allergy or Eczema 0.2 0.5 1.9 -0.1 -0.3 1.1 1.4 -0.2 0.7 0.3
Cardiovascular Disease 0.8 2.8 6.4 -2.5 -1.8 -0.9 -0.6 -2.1 -1.7 -1.2
Hypothyroidism (self reported) 0.3 0.6 1.7 0.1 0.2 -1.3 -1.0 0.8 -0.9 -0.2
Respiratory disease 0.2 0.4 0.8 0.9 0.6 -0.9 0.2 0.7 -0.4 0.2
Type 2 Diabetes (T2D) (2018) 0.7 1.2 2.2 -1.2 -1.5 -0.0 -1.0 -1.5 -0.5 -1.2
Lung FEV1/FVC ratio 0.6 2.8 5.1 1.5 2.2 -2.1 -1.8 1.1 -1.5 -0.8
Lung FVC 5.4 27.5 79.4 -8.9 -7.7 1.0 -0.7 -6.0 -2.8 -2.9
Neuroticism 0.7 1.6 4.7 -1.8 -2.2 1.0 1.0 -1.2 0.2 -0.1
Chronotype (morning person) 0.2 0.4 0.8 0.4 0.5 0.9 0.9 -0.0 0.6 0.4
Hair Pigment 0.1 3.7 11.3 0.6 2.2 -3.4 -1.4 -0.7 -2.6 -0.7
Tanning 0.0 0.6 1.4 0.8 0.6 0.2 0.5 1.2 0.5 1.0
Hand grip strength (left) 0.9 2.3 5.4 -2.3 -1.9 -0.2 0.2 -2.3 -0.7 -1.0
Number of treatments/medications taken 0.1 0.2 0.6 -0.5 0.0 -0.3 -0.3 -0.7 -0.7 -0.1
Average weekly spirits intake 0.5 0.6 1.8 -0.9 -1.3 0.4 -0.7 0.6 0.0 -0.8
Sensitivity / hurt feelings 1.3 2.3 4.8 -2.1 -2.2 1.1 0.9 -2.2 0.1 0.3
Frequency of depressed mood in last 2 weeks 1.0 1.4 3.0 -0.3 -0.3 -1.2 -1.7 -1.4 -1.5 -0.8
Hearing difficulty/problems: Yes 0.9 1.3 4.7 1.6 2.2 -0.9 -0.9 0.4 -0.2 0.3
Relative age of first facial hair 1.8 3.8 8.3 -1.4 0.1 -2.9 -1.8 -1.3 -2.4 -2.4
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.3 -0.0 0.3 -1.2 -1.3 -0.8 -1.5 -0.4
Ever used hormone-replacement therapy (HRT) 2.8 3.5 7.6 0.3 0.1 2.8 2.7 -0.3 2.3 2.1
Ever had hysterectomy (womb removed) 0.6 0.7 2.2 -1.5 -1.1 0.4 0.2 -0.8 -0.3 -0.5
Systolic blood pressure, automated reading 0.6 1.7 4.0 -0.6 0.7 -1.4 -1.6 -1.0 -2.0 -1.2
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 1.6 0.4 -0.2 0.4 0.4 1.3 0.7 -0.0
Angina 0.6 0.8 1.7 0.7 0.6 -1.3 -1.3 -0.2 -0.9 -0.8
Medication for hormone replacement therapy 0.8 0.9 1.9 -0.9 -0.8 1.2 1.4 -0.6 0.5 0.8
Vitamin and mineral supplements 0.4 0.6 2.0 0.9 -0.0 -0.1 0.6 1.4 0.8 0.5
Supplements: Zinc 0.5 0.6 2.3 1.0 1.5 -0.4 -0.4 -0.6 -0.3 0.3
Medication: Co-codamol 0.1 0.1 0.2 -0.4 -0.2 -0.4 0.1 -0.3 -0.2 0.1
Medication: Metformin 1.7 2.4 4.0 -1.6 -1.9 -0.7 -1.7 -1.2 -1.4 -2.0
Diabetes (father) 0.5 0.6 1.1 0.9 1.0 -0.7 -0.8 1.0 -0.1 -0.1
Diabetes (mother) 1.6 2.1 4.4 -0.1 0.7 -2.1 -1.8 -0.4 -2.1 -1.3
Severe depression (siblings) 1.9 2.2 3.5 -1.3 -1.3 -1.4 -1.9 -0.5 -1.9 -1.6
Pack years adult smoking proportion 0.5 0.8 2.2 0.2 -0.9 1.5 1.1 0.3 0.8 0.7
Impedance of leg (right) 0.4 2.1 4.6 1.8 0.3 0.9 1.5 2.1 1.4 1.3
Leg fat-free mass (left) 0.2 0.9 4.9 -1.0 0.0 0.5 0.1 -2.2 0.1 -0.3
Trunk fat percentage 1.7 6.8 18.9 4.2 4.3 -0.3 1.3 1.8 1.6 1.9
Hand grip strength (right) 1.0 2.8 7.1 -2.7 -2.1 -0.8 -0.4 -1.8 -1.2 -1.6
Townsend deprivation index at recruitment 0.3 0.4 1.3 1.2 0.7 0.2 0.5 -0.6 0.6 0.5
Current tobacco smoking 0.7 1.1 3.2 0.3 0.0 1.8 1.6 0.1 0.9 1.0
Average weekly fortified wine intake 0.4 0.5 1.0 0.3 -0.4 0.5 0.7 1.0 0.7 0.8
Maternal smoking around birth 0.9 1.3 3.6 -0.2 -0.2 -1.0 -1.9 -0.1 -1.1 -1.8
Fed-up feelings 1.6 2.8 8.1 -1.1 -0.8 -1.7 -1.0 -2.8 -2.0 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 2.9 -0.4 -0.4 -0.8 -1.4 -1.4 -1.7 -1.2
Relative age voice broke 0.3 0.4 1.0 -0.1 0.1 -1.0 -0.5 0.4 -0.6 -1.0
Taking other prescription medications 0.2 0.4 0.6 0.8 0.6 -0.7 -0.2 0.7 -0.5 -0.2
Age when periods started (menarche) 0.3 0.8 2.7 -0.5 -0.9 0.0 0.7 1.7 0.6 0.8
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 4.7 -2.1 -2.2 1.3 0.6 -0.5 0.3 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 3.2 1.5 0.6 1.8 -0.3 0.4 1.7 0.1
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 4.5 0.5 -0.0 0.7 1.0 2.1 0.5 0.6
Qualifications: CSEs or equivalent 5.9 7.7 13.6 -2.3 -1.8 -2.3 -3.2 -2.6 -3.1 -3.7
Serious illness, injury or assault to yourself 1.1 1.3 3.6 0.9 1.4 -1.9 -1.1 -0.4 -1.2 -0.2
High blood pressure 0.5 1.4 3.3 -0.7 0.9 -1.5 -0.9 -0.9 -1.8 -1.2
Hayfever, allergic rhinitis or eczema 0.4 0.8 3.6 -0.5 -0.6 0.6 1.9 0.1 0.5 0.9
Multivitamins +/- minerals 0.4 0.5 1.4 -0.5 -0.4 0.6 -0.8 -1.2 -0.3 -0.7
Stomach or abdominal pain in last month 1.7 2.1 6.0 1.7 2.5 -1.5 0.5 1.4 -0.5 1.0
Supplements: Glucosamine 1.2 1.6 3.5 0.6 0.2 1.9 1.6 0.4 1.8 1.2
Diverticular disease/diverticulitis (self-reported) 1.6 1.9 3.8 1.9 1.2 0.8 1.5 1.5 1.3 1.3
Medication: Atenolol 1.3 1.6 3.3 -0.5 0.1 -1.4 -1.8 -1.0 -1.4 -1.6
Medication: Levothyroxine sodium 0.8 1.3 2.6 1.4 1.6 -1.6 -0.7 1.0 -0.7 0.5
Sitting height 1.3 9.2 19.4 -3.3 -3.8 4.4 0.9 -3.8 1.8 -0.8
Chronic bronchitis/emphysema (father) 0.3 0.3 1.3 -0.3 -0.4 -0.2 1.1 -0.7 0.1 0.6
High blood pressure (mother) 3.4 4.7 13.2 -1.6 -0.1 -3.6 -2.0 -1.5 -2.9 -1.7
Body mass index (BMI) 1.0 4.4 15.4 2.9 3.9 -1.0 1.1 1.0 0.6 1.7
Impedance of leg (left) 0.6 3.0 5.6 2.2 0.9 0.7 1.8 2.4 1.7 1.8
Leg predicted mass (left) 0.2 1.0 5.2 -1.1 -0.1 0.5 0.0 -2.3 0.1 -0.4
Trunk fat mass 1.2 5.1 14.2 3.4 3.8 0.1 1.6 1.1 1.7 1.9
Waist circumference 1.2 4.3 12.0 2.5 3.5 -0.5 1.9 0.8 1.3 2.5
Number of incorrect matches in round 2.3 3.8 7.4 -1.4 0.1 -2.5 -1.6 -2.7 -2.7 -1.1
Past tobacco smoking 0.7 1.3 5.0 -0.8 -2.2 1.2 -0.5 0.9 0.7 0.0
Alcohol usually taken with meals 0.4 0.6 1.2 -0.8 -0.5 1.0 0.8 -0.4 1.1 0.5
Nervous feelings 0.8 1.4 6.1 -1.6 -2.5 0.7 0.4 -0.4 -0.3 -0.7
Frequency of tenseness / restlessness in last 2 weeks 2.3 3.5 11.6 -1.1 -1.1 -0.6 -1.8 -3.4 -2.0 -1.6
Hearing difficulty/problems with background noise 1.3 2.0 6.9 2.0 2.6 -0.1 0.1 0.6 0.8 1.4
Hair/balding pattern: Pattern 2 2.8 3.6 5.7 -2.3 -1.4 -1.7 -1.7 -1.6 -2.4 -1.9
Had menopause 0.8 1.0 2.4 -1.0 -1.3 1.0 -0.2 -1.5 0.3 -1.0
Had other major operations 3.7 4.5 12.6 3.5 3.2 -0.3 0.4 2.0 1.2 1.7
Forced vital capacity (FVC) 4.1 15.9 37.5 -6.1 -5.8 2.1 -0.3 -5.4 -0.9 -2.2
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 2.4 0.6 0.5 0.5 -1.6 -0.6 0.0 -0.7
Ever unenthusiastic/disinterested for a whole week 2.3 2.8 6.0 -2.0 -2.5 -0.5 -0.9 -2.0 -1.6 -1.4
Qualifications: None of the above 2.1 4.5 8.6 2.9 2.9 -0.8 1.0 2.8 1.1 2.0
Financial difficulties in last 2 years 0.4 0.5 1.2 0.5 1.0 -0.7 0.7 0.1 -0.1 1.1
Mouth/teeth dental problems 1.5 2.3 4.1 -2.0 -2.0 0.6 -1.4 -1.3 -0.4 -1.9
Heart attack 0.2 0.2 0.7 -0.3 0.1 -0.2 0.0 -0.9 -0.3 -0.6
Allergy 0.1 0.2 0.8 0.3 0.4 0.4 -0.9 0.2 0.5 -0.1
Pain all over the body in last month 0.3 0.4 1.6 0.0 0.6 -0.3 0.3 -1.2 -0.5 -0.4
Diabetes (self-reported) 1.0 1.5 2.7 -1.6 -1.6 -0.0 -1.0 -1.0 -1.1 -1.4
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 2.1 -0.7 -0.9 0.3 1.4 -0.1 0.6 0.4
Medication: Ramipril 1.1 1.4 3.6 -1.1 -0.9 0.9 1.9 0.2 1.0 1.6
Medication: Simvastatin 0.6 0.9 3.0 -1.7 -1.7 0.2 0.4 -0.6 -0.3 -0.2
Fluid intelligence score 1.1 2.3 5.9 -1.5 -2.4 2.1 -0.2 -0.9 1.0 -1.2
Illnesses of siblings 1.9 2.6 6.2 0.6 0.5 1.2 2.1 1.6 1.8 2.5
Neuroticism score 1.4 2.9 7.3 -2.2 -2.7 0.2 -0.0 -2.5 -1.0 -1.0
Weight 0.4 2.1 5.5 1.7 2.3 0.7 1.4 -0.5 1.4 1.3
Impedance of arm (right) 0.1 0.5 1.6 1.3 -0.2 0.6 -0.8 0.8 0.5 -0.4
Arm fat percentage (right) 1.8 7.0 21.7 4.0 4.7 -0.8 1.2 1.7 1.2 2.0
Trunk fat-free mass 0.5 2.9 6.9 -2.4 -1.6 1.7 1.4 -2.6 0.8 0.2
Hip circumference 0.8 3.3 5.1 1.6 2.2 1.3 2.1 -0.2 2.0 2.2
Time employed in main current job 1.1 1.3 3.9 -1.9 -2.0 0.4 0.8 -0.2 0.1 -0.6
Alcohol intake versus 10 years previously 0.8 1.3 2.7 1.0 1.6 -0.8 1.5 0.6 0.5 1.3
Father’s age at death 0.0 0.1 0.2 0.0 0.2 -0.1 -0.3 0.2 0.1 -0.4
Worrier / anxious feelings 0.8 1.5 4.2 -2.0 -2.0 0.4 0.9 -1.0 -0.7 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 2.0 0.9 0.7 -0.1 -1.4 -1.2 -0.6 -0.8
Falls in the last year 0.9 1.2 3.8 1.7 1.9 -0.8 0.5 -0.3 0.2 0.8
Hair/balding pattern: Pattern 3 0.4 0.6 1.4 -0.6 -0.5 0.1 0.9 -1.0 0.6 1.2
Number of live births 0.9 1.3 3.2 0.7 0.5 0.5 1.8 1.5 0.8 1.5
Forced expiratory volume in 1-second (FEV1) 3.1 10.5 23.9 -4.9 -4.5 1.2 -1.0 -4.4 -1.2 -2.4
Pulse rate 0.4 0.7 1.6 -0.4 0.4 -0.7 -1.0 -0.1 -1.1 -1.2
Happiness 0.5 0.7 1.6 0.0 -1.3 0.8 -0.8 -0.3 -0.3 -1.2
Noisy workplace 0.4 0.5 1.5 0.1 0.0 -0.7 0.6 1.2 -0.2 1.0
Qualifications: A levels/AS levels or equivalent 1.4 3.1 6.0 -2.4 -1.5 -1.4 -1.6 -1.8 -1.9 -1.2
Serious illness, injury or assault of a close relative in last 2 years 2.1 2.4 5.2 -1.3 -1.2 -1.4 -2.3 -1.0 -1.5 -1.9
Mouth/teeth dental problems: Dentures 1.4 2.3 6.2 2.2 2.5 -0.7 0.9 1.1 0.4 1.6
Asthma 0.1 0.2 0.4 0.5 0.5 -0.6 0.6 0.4 -0.3 0.5
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.8 -0.9 -1.3 1.1 1.2 0.4 0.7 1.0
Medication: Cholesterol lowering 0.9 1.3 3.9 -1.5 -0.7 -2.0 -0.4 -0.2 -1.6 -0.3
Depression (self-reported) 1.0 1.2 2.7 0.0 -0.3 -1.1 -1.5 -1.6 -1.2 -0.9
Medication: Lansoprazole 0.5 0.5 3.4 0.3 -0.1 -0.1 0.2 1.8 -0.0 0.4
Prospective memory result 0.7 0.9 1.9 1.4 1.2 -0.8 -0.3 1.4 -0.3 0.4
Lung cancer (father) 0.1 0.1 0.4 0.4 0.1 -0.7 0.2 0.1 -0.0 0.4
Illnesses of mother 6.7 8.3 13.8 2.4 0.8 3.7 3.0 2.8 3.7 2.7
Forced expiratory volume in 1-second (FEV1), Best measure 3.3 10.7 24.8 -5.0 -4.3 0.4 -1.1 -4.6 -2.1 -2.2
Pulse wave Arterial Stiffness index 0.9 1.0 2.6 -1.6 -1.1 -0.1 -0.5 -1.6 -0.5 -0.6
Impedance of arm (left) 0.2 1.1 1.8 1.2 -0.8 1.3 -0.9 1.3 0.9 -0.7
Arm fat mass (right) 1.2 4.9 15.5 3.0 3.9 -0.3 1.6 0.7 1.4 2.1
Trunk predicted mass 0.5 2.9 6.9 -2.4 -1.6 1.7 1.3 -2.6 0.7 0.2
Standing height 0.6 6.1 12.6 -2.5 -3.2 3.5 0.9 -3.0 1.8 -0.6
Length of working week for main job 0.2 0.2 0.5 -0.0 0.3 -0.2 -0.7 -0.2 -0.5 -0.6
Exposure to tobacco smoke at home 0.6 0.7 1.5 -1.0 -0.2 -1.2 -0.1 -0.8 -1.1 -0.6
Breastfed as a baby 3.7 4.6 7.2 -2.7 -1.9 -1.3 -2.3 -2.2 -2.5 -1.8
Tense / ‘highly strung’ 2.3 3.8 6.9 -2.6 -2.6 -1.2 -1.0 -2.3 -1.9 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.7 5.0 -2.0 -1.4 -1.1 -0.8 -2.2 -2.0 -1.3
Hair/balding pattern: Pattern 4 0.1 0.3 0.8 0.5 0.7 -0.1 -0.9 0.0 -0.5 -0.8
Birth weight of first child 0.4 0.7 1.7 -1.0 -1.3 0.2 -0.7 1.1 -0.2 -0.8
Peak expiratory flow (PEF) 1.6 3.8 9.2 -2.7 -3.0 2.4 0.4 -1.5 0.8 -1.0
Pulse wave reflection index 0.6 0.8 2.2 -1.0 -1.5 -0.4 -0.4 -1.0 -0.4 -0.7
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.1 -1.0 -1.0 -0.0 0.5 -0.0 -0.6 0.1
Loud music exposure frequency 1.5 1.6 4.0 0.3 1.0 -2.0 -0.9 -1.1 -1.8 -1.0
Qualifications: O levels/GCSEs or equivalent 1.1 1.8 4.5 -1.9 -1.9 0.1 -0.5 -2.1 -0.6 -0.8
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.7 0.4 0.8 -0.2 0.8 0.7 0.2 0.8
Blood clot in the leg (DVT) 1.0 1.3 2.0 1.2 1.1 -1.4 -1.4 -0.4 -1.3 -0.9
Medication: Paracetamol 0.2 0.4 0.9 -0.4 -1.0 0.7 0.5 -0.6 0.0 0.6
Headache pain in last month 0.7 1.3 2.9 -0.3 -0.2 1.3 1.7 -0.4 1.1 1.7
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 4.6 0.3 -0.8 2.1 0.9 -0.0 1.4 -0.3
Glaucoma (self-reported) 0.6 0.7 3.6 1.0 0.5 -0.2 -0.1 1.9 0.2 0.4
Gout (self-reported) 0.6 0.8 2.6 0.1 0.2 0.1 -1.6 -0.6 -0.4 -1.6
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 2.3 0.4 0.6 -1.5 -0.8 1.0 -0.9 0.0
Medication: Amlodipine 1.0 1.4 4.2 1.0 2.0 -1.6 -1.0 -0.2 -1.1 0.0
Medication: Ventolin 100micrograms inhaler 1.5 1.9 4.5 0.4 -0.3 2.1 2.1 0.3 1.8 1.1
Birth weight 0.2 0.4 0.9 -0.7 -1.0 0.7 0.7 -0.1 0.4 0.1
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.8 0.9 0.4 0.2 -0.0 0.3 0.3 0.1
High blood pressure (siblings) 2.6 3.7 6.3 -1.6 -0.9 -1.3 -2.1 -2.5 -2.2 -2.3
Forced vital capacity (FVC), Best measure 3.9 14.3 33.9 -5.8 -5.2 0.9 -0.9 -5.3 -2.0 -2.3
Body fat percentage 2.2 8.7 24.2 4.6 4.9 -0.6 1.6 2.2 1.7 2.4
Leg fat percentage (right) 3.0 10.8 26.6 4.7 5.2 -0.6 2.5 2.6 1.9 3.1
Arm fat-free mass (right) 0.2 1.0 3.3 -1.4 -0.4 1.0 0.9 -1.8 0.5 0.0
Exposure to tobacco smoke outside home 0.5 0.7 2.1 0.4 0.4 -1.5 -0.3 0.6 -1.1 -0.6
Comparative body size at age 10 0.9 2.5 5.2 0.3 -0.1 2.2 2.3 0.9 2.1 1.5
Number of full brothers 0.4 0.5 1.0 0.5 0.5 -1.0 -1.0 0.1 -0.7 -0.8
Worry too long after embarrassment 1.7 2.9 10.7 -2.1 -3.3 1.2 0.3 -1.7 -0.4 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.9 5.2 -1.2 -0.8 -0.4 -1.0 -2.3 -1.8 -1.3
Wheeze or whistling in the chest in last year 0.2 0.4 0.7 0.3 0.8 -0.8 0.8 -0.0 -0.4 0.7
Number of children fathered 0.5 0.6 1.5 -1.1 -1.2 -0.1 -0.1 -0.7 -0.5 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 1.4 -0.5 -0.3 -0.3 -1.0 -0.7 -0.7 -1.2
Age at first live birth 0.5 0.8 3.0 -0.5 -0.9 1.7 0.4 0.2 1.1 0.4
Pulse wave peak to peak time 0.8 1.0 2.5 1.6 1.1 0.4 0.6 1.4 0.7 0.6
Health satisfaction 0.3 0.4 1.8 -0.6 -0.3 -0.8 0.2 -0.4 -1.3 0.0
Shortness of breath walking on level ground 1.7 2.1 4.3 2.1 1.6 -1.2 0.4 1.8 -0.1 1.6
Qualifications: College or University degree 0.2 0.6 2.0 -0.5 -1.1 1.4 -0.4 -0.3 0.8 -0.2
Eye problems/disorders: None of the above 0.1 0.1 0.3 0.3 0.1 -0.1 -0.4 -0.3 -0.6 -0.2
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.4 -0.6 -0.2 0.2 1.2 -0.8 0.3 0.5
Emphysema/chronic bronchitis 0.5 0.6 1.8 -0.4 -0.9 1.0 0.5 -1.3 0.5 0.3
Medication for pain relief, constipation, heartburn 0.2 0.4 0.7 0.2 0.6 -0.8 -0.9 -0.4 -0.6 -0.7
Neck or shoulder pain in last month 0.8 1.2 2.7 1.4 1.5 -0.8 -0.3 1.7 -0.3 0.6
Medication: Blood pressure 1.1 1.9 4.1 1.3 2.0 -1.8 -1.2 1.5 -1.0 -0.0
Angina (self-reported) 1.1 1.5 3.0 0.2 0.2 -1.7 -1.7 -0.4 -1.5 -1.4
Migraine (self-reported) 0.1 0.1 0.4 -0.2 0.1 0.5 0.6 0.3 0.1 -0.0
Medication: Ibuprofen 1.1 1.3 2.7 -0.6 -1.0 1.2 1.6 0.8 1.1 1.4
Medication: Allopurinol 1.0 1.4 4.9 0.4 0.6 -0.2 -2.2 -0.1 -0.6 -1.9
Medication: Omeprazole 0.2 0.2 0.5 0.6 0.5 -0.3 0.4 0.7 0.1 0.1
Medication: Seretide 50 evohaler 0.8 0.9 1.9 -1.3 -0.8 -1.0 -0.3 0.0 -1.4 -1.0
Mean time to correctly identify matches 0.2 0.4 0.9 0.5 1.0 -0.8 0.5 0.1 0.2 0.8
Heart disease (mother) 1.7 2.1 5.3 -0.2 0.4 -1.2 -2.3 -1.5 -1.5 -1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.6 2.8 0.7 0.5 1.3 1.4 1.2 1.7 1.5
Whole body fat mass 1.4 6.0 17.3 3.5 4.2 -0.1 1.8 1.1 1.7 2.3
Leg fat mass (right) 1.6 6.1 18.4 3.3 4.3 -0.6 2.0 1.2 1.4 2.4
Arm predicted mass (right) 0.2 1.2 3.9 -1.5 -0.4 0.9 1.1 -2.0 0.5 0.3
Pulse rate, automated reading 0.6 1.9 8.6 1.6 2.9 -0.7 0.8 1.0 0.0 0.7
Alcohol intake frequency. 1.1 2.5 5.7 2.0 2.4 -1.4 0.7 1.7 0.1 1.5
Comparative height size at age 10 0.5 2.7 9.5 -0.4 -1.1 3.1 1.0 -1.1 2.3 0.9
Number of full sisters 0.6 0.7 1.7 0.7 1.1 -1.0 -0.3 -0.5 -1.3 -0.6
Suffer from ‘nerves’ 1.1 1.8 3.0 -1.7 -1.2 -1.6 -0.1 -1.3 -1.7 -0.8
Overall health rating 0.1 0.2 0.4 0.3 0.1 -0.5 -0.4 0.4 -0.6 -0.6
Chest pain or discomfort 0.4 0.6 2.1 -0.1 0.3 -1.4 -0.8 -0.3 -1.2 -0.1
Had major operations 0.6 0.7 1.5 0.9 1.1 -0.7 -0.3 0.8 -0.4 1.2
Age at last live birth 0.3 0.5 1.3 0.7 0.3 -0.7 -0.8 1.2 -0.5 -0.2
Family relationship satisfaction 0.2 0.2 0.9 0.0 0.1 -0.1 0.3 -1.0 -0.6 0.1
Leg pain on walking 0.5 0.6 1.4 -0.7 -0.0 -1.1 0.5 -0.9 -1.2 0.2
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.5 2.5 -1.1 -0.6 -1.1 -0.8 -1.4 -1.5 -1.6
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.1 -1.0 -0.9 1.0 0.7 0.3 0.3 0.3
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 3.7 -1.7 -1.9 1.4 0.8 -0.1 0.4 -0.2
Medication: Aspirin 0.8 1.0 2.0 -0.5 -0.0 -0.9 -1.4 -0.8 -1.2 -1.4
Supplements: Vitamin C 0.3 0.3 0.6 0.1 0.8 -0.7 0.6 -0.5 -0.4 0.6
Knee pain experienced in last month 0.1 0.2 0.6 -0.1 -0.4 0.4 0.4 -0.5 0.2 0.8
Hypertension (Self-reported) 0.4 1.1 2.7 -0.7 0.7 -1.2 -0.6 -0.9 -1.6 -1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 -0.1 -0.2 -0.3 -0.0 -0.3 -0.3 -0.4
Illnesses of father: Heart disease 0.3 0.5 1.2 -0.7 0.0 -0.4 -0.0 -1.1 -0.9 -0.7
Illnesses of siblings: Diabetes 0.8 1.0 2.6 1.3 1.6 -0.7 0.7 0.1 0.4 1.4
Smoking status: Previous 0.9 1.4 4.9 1.0 2.2 -1.5 0.8 0.5 -0.5 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.6 2.7 -1.4 -1.6 0.2 -1.2 -1.4 -1.1 -1.6
Whole body fat-free mass 0.3 1.8 6.4 -1.9 -0.8 1.2 0.8 -2.5 0.5 0.0
Leg fat-free mass (right) 0.2 1.2 6.2 -1.3 -0.2 0.5 -0.0 -2.5 0.1 -0.4
Arm fat percentage (left) 1.7 6.6 20.2 4.0 4.5 -0.7 1.0 1.9 1.2 1.8
Average weekly red wine intake 0.5 0.8 2.4 -0.8 -0.4 1.0 0.9 -1.6 0.6 0.5
Handedness (chirality/laterality): Left-handed 1.7 2.0 4.7 1.7 2.2 -1.4 -1.8 -0.3 -0.9 -0.8
Mood swings 0.4 0.7 2.1 -0.1 -0.4 -0.6 -0.6 -1.4 -1.0 -0.9
Loneliness, isolation 0.4 0.6 2.6 -0.7 -1.6 0.6 0.5 -0.1 0.4 0.3
Long-standing illness, disability or infirmity 0.7 1.0 2.6 0.3 0.6 -1.3 -1.6 0.5 -1.2 -0.9
Ever had bowel cancer screening 0.4 0.4 1.5 0.0 -0.1 0.3 1.2 0.5 0.8 0.7
Diabetes diagnosed by doctor 0.7 1.1 1.9 -1.4 -1.3 -0.1 -0.9 -1.0 -1.0 -1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 2.7 0.9 1.3 -1.6 0.4 0.7 -0.4 0.7
Friendships satisfaction 0.7 0.9 1.8 -0.9 -1.3 -0.3 -0.9 0.5 -1.2 -0.9
Qualifications: nursing, teaching 1.1 1.7 4.2 -2.0 -2.0 0.9 0.3 -1.7 -0.1 -0.2
Commuting to job workplace: Walk 0.5 0.6 1.4 -1.2 -0.7 -0.6 -0.2 -1.0 -0.7 -0.1
Eye problems/disorders: Cataract 0.9 1.0 2.9 -1.5 -1.1 -0.3 -0.4 -1.7 -0.3 -0.7
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.1 -0.9 -1.1 0.2 -0.1 -0.2 -0.2 -0.4
Medication for cholesterol 0.4 0.6 1.8 0.4 0.0 -0.8 -1.2 1.3 -0.1 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 4.6 -2.1 -1.7 -0.2 0.6 -1.1 -0.4 0.3
Back pain experienced in last month 0.8 1.2 4.2 0.2 0.3 -0.1 1.2 1.5 0.4 2.0
Mineral and other dietary supplements 0.4 0.5 2.0 0.4 0.1 -1.2 -0.3 1.4 -0.3 -0.2
Breast cancer (self-reported) 0.5 0.6 1.3 1.0 1.2 -0.4 -0.5 1.1 -0.3 -0.3
Asthma (self-reported) 0.1 0.2 0.8 0.4 0.4 -0.9 0.4 0.5 -0.5 0.2
Osteoporosis (self-reported) 0.3 0.3 2.2 0.3 -0.0 -0.2 -0.1 1.5 0.1 -0.1
Osteoarthritis (self-reported) 0.4 0.6 2.0 0.5 0.4 -0.8 -1.4 -0.5 -0.8 -0.3
Medication: Aspirin 0.6 0.8 1.9 -0.5 0.0 -0.9 -1.2 -0.7 -0.9 -1.4
Medication: Gliclazide 1.7 2.0 3.7 -0.9 -0.8 -1.3 -1.9 -0.8 -1.8 -1.6
Illnesses of father: None of the above (group 1) 1.7 2.2 3.7 1.0 -0.1 1.9 1.7 1.2 1.9 1.6
Smoking status: Current 0.6 1.0 3.1 0.4 0.3 1.8 1.4 -0.2 1.0 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.7 5.8 14.3 -3.8 -3.0 -0.3 -1.4 -2.7 -2.0 -2.0
Whole body water mass 0.4 2.0 7.0 -2.0 -0.9 1.2 0.9 -2.6 0.5 0.0
Leg predicted mass (right) 0.2 1.2 6.0 -1.4 -0.3 0.6 -0.0 -2.4 0.1 -0.4
Arm fat mass (left) 0.9 3.7 12.1 2.7 3.5 -0.3 1.4 0.8 1.1 1.7
Number of self-reported non-cancer illnesses 0.1 0.1 0.2 0.5 0.4 -0.4 -0.3 -0.1 -0.3 -0.5
Average weekly champagne plus white wine intake 1.2 1.6 3.8 0.7 0.2 1.0 1.9 0.4 1.5 1.9
Miserableness 1.7 2.9 6.0 -2.2 -2.5 0.0 -0.8 -2.4 -1.0 -1.3
Guilty feelings 0.8 1.2 3.7 -1.2 -1.9 1.3 0.1 -0.7 0.4 -0.7
Wears glasses or contact lenses 0.3 0.4 0.8 -0.0 -0.5 0.8 0.0 -0.8 0.3 -0.9
Ever taken oral contraceptive pill 0.4 0.4 1.0 0.1 -0.3 1.0 -0.4 1.0 0.7 -0.7
Hearing aid user 0.4 0.5 1.4 0.3 0.2 0.9 -0.9 -0.4 -0.1 -1.2
Mother’s age at death 0.8 1.0 2.5 -0.9 -0.5 -1.2 -0.7 -0.5 -1.6 -1.1
Financial situation satisfaction 0.5 0.6 1.6 -0.3 0.0 -1.0 -0.5 -1.0 -1.3 -0.7
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.8 -0.1 -0.7 1.3 0.0 -0.4 0.3 -0.2
Commuting to job workplace: Public transport 0.1 0.2 0.4 -0.3 -0.5 -0.4 -0.1 -0.7 -0.0 -0.3
Eye problems/disorders: Glaucoma 0.4 0.5 0.9 -0.4 -0.5 -0.7 -0.9 0.7 -0.9 -0.8
Medication: Blood pressure 0.3 0.5 1.9 -0.1 0.6 0.3 1.0 -1.4 -0.1 0.3
Pain type(s) experienced in last month: Hip pain 1.8 2.3 5.2 2.3 1.4 1.4 0.4 1.4 1.8 1.2
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.5 -0.9 -1.0 1.5 -0.1 -1.6 0.5 -0.2
High cholesterol (Self-reported) 0.1 0.2 0.6 -0.8 -0.7 -0.3 0.1 -0.2 -0.5 -0.1
Medication: Bendroflumethiazide 0.4 0.7 1.9 1.1 1.4 -0.5 0.1 1.0 -0.1 0.4
Medication: Paracetamol 0.3 0.5 1.7 -0.2 -0.7 1.3 0.5 -0.5 0.5 0.7
Medication: Lisinopril 1.3 1.7 3.6 -0.7 -0.4 -1.8 -1.8 0.0 -1.9 -1.1
Medication: Atorvastatin 0.8 0.9 2.1 0.7 1.2 -1.4 -1.1 -0.6 -0.7 -0.3
Illnesses of father: High blood pressure 2.8 3.5 5.7 -1.0 -0.2 -1.7 -2.4 -2.1 -2.3 -2.2
Alcohol drinker status: Never 1.3 1.6 3.5 -1.9 -1.7 0.3 -0.7 -1.6 -0.6 -1.1
Ever smoked 0.4 0.6 1.4 0.2 1.2 -0.2 1.1 -1.2 -0.1 0.6
Basal metabolic rate 0.2 1.2 4.6 -1.1 -0.1 1.1 1.0 -2.1 0.7 0.3
Leg fat percentage (left) 3.1 11.3 28.0 4.7 5.3 -0.6 2.7 2.5 1.9 3.3
Arm fat-free mass (left) 0.3 1.3 5.4 -1.5 -0.3 0.6 1.0 -2.3 0.3 0.2
Number of operations (self-reported) 1.2 1.8 4.1 1.7 1.4 0.5 0.8 1.2 1.2 2.0
Average weekly beer plus cider intake 0.7 1.1 2.4 -1.0 -1.5 -0.6 -0.9 -1.0 -0.3 -1.4
Irritability 1.0 1.8 4.6 -1.6 -1.9 0.7 -0.3 -2.1 -0.5 -0.9
Risk taking 1.1 1.5 4.9 -0.3 0.9 -2.2 -1.0 -1.1 -1.6 -0.1
Ever had prostate specific antigen (PSA) test 1.1 1.3 4.1 1.4 2.0 -0.9 -0.1 -0.5 0.4 1.2
Fractured/broken bones in last 5 years 0.5 0.6 1.1 0.6 0.8 -0.8 -0.8 -1.1 -0.8 -0.6
Age started oral contraceptive pill 0.8 1.0 2.2 -0.9 -1.4 1.1 -0.4 -1.5 0.3 -0.5
Diastolic blood pressure, automated reading 0.3 0.9 3.8 0.8 2.0 -0.5 -0.6 -0.8 -0.5 -0.2
Ever depressed for a whole week 0.7 0.9 3.7 -1.3 -1.9 0.2 0.1 -0.9 -0.5 -0.1
Unable to work because of sickness or disability 3.0 3.8 8.6 -0.2 0.3 -2.8 -2.9 0.3 -2.5 -2.0
Commuting to job workplace: Cycle 0.5 0.6 1.4 -0.5 -0.0 -1.2 -0.5 -0.7 -0.9 -1.0
Myopia 0.6 0.9 2.5 -1.0 -1.6 0.2 -0.2 -0.8 -0.6 -1.2
Vascular/heart problems diagnosed by doctor 0.4 1.0 2.3 0.7 -0.9 1.1 0.6 1.1 1.5 0.9
Cholesterol lowering medication 0.2 0.3 0.9 -0.2 -0.2 0.8 0.7 -0.9 0.5 -0.2
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.9 0.8 0.4 -0.2 0.5 1.0 0.3 0.1
Pain experienced in last month 1.0 1.6 4.2 -0.2 0.0 -1.1 -2.0 -0.5 -1.2 -2.0
Supplements: Calcium 0.5 0.6 1.3 -1.1 -1.1 -0.5 0.7 0.1 -0.8 0.3
Basal cell carcinoma (self-reported) 0.8 1.0 2.2 0.2 -0.5 1.3 1.1 1.5 0.9 0.9
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.9 -0.4 -0.0 -0.2 -0.1 -0.9 -0.3 -0.8
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 2.1 1.1 1.1 -1.4 -1.2 -0.3 -1.4 -0.7
Heart disease (siblings) 0.3 0.3 0.8 0.9 0.8 0.1 0.2 -0.8 0.2 -0.4
Alcohol drinker status: Previous 0.4 0.5 1.3 0.7 0.5 0.1 0.9 1.1 0.3 0.7
Pack years of smoking 0.7 1.0 2.9 0.3 -0.8 1.7 1.3 0.1 1.0 0.8
Impedance of whole body 0.2 1.2 3.5 1.9 0.2 0.7 -0.1 1.9 0.9 0.2
Leg fat mass (left) 1.7 6.5 19.5 3.4 4.4 -0.6 2.0 1.2 1.4 2.6
Arm predicted mass (left) 0.3 1.3 5.5 -1.4 -0.1 0.8 1.0 -2.3 0.4 0.3