Best TWAS P=3.09e-23 · Best GWAS P=9.4e-19 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | BOK | 0.20 | 0.12 | lasso | 4 | 0.12 | 1.4e-06 | -8.8 | -8.4 | 5.6e-17 | 0.97 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Brain Frontal Cortex BA9 | SEPT2 | 0.30 | -0.01 | enet | 32 | 0.02 | 1.1e-01 | 3.3 | 5.6 | 1.6e-08 | -0.13 | 0.07 | 0.05 | TRUE |
| 3 | GTEx | Heart Atrial Appendage | BOK | 0.15 | 0.01 | enet | 18 | 0.08 | 2.1e-04 | -8.8 | -7.7 | 1.2e-14 | 0.60 | 0.01 | 0.93 | FALSE |
| 4 | GTEx | Liver | AC114730.8 | 0.23 | -0.01 | enet | 27 | 0.03 | 6.5e-02 | -8.8 | 5.4 | 5.5e-08 | -0.51 | 0.01 | 0.79 | FALSE |
| 5 | GTEx | Whole Blood | PASK | 0.25 | 0.15 | enet | 10 | 0.21 | 4.4e-19 | 5.7 | -5.5 | 3.0e-08 | 0.01 | 1.00 | 0.00 | TRUE |
| 6 | GTEx | Whole Blood | MTERFD2 | 0.10 | 0.06 | enet | 16 | 0.06 | 3.0e-06 | 5.2 | -6.6 | 3.1e-11 | 0.07 | 0.90 | 0.00 | TRUE |
| 7 | METSIM | Adipose | BOK | 0.06 | 0.03 | lasso | 6 | 0.03 | 7.8e-06 | -8.8 | -9.9 | 3.1e-23 | 0.95 | 0.00 | 1.00 | TRUE |
| 8 | NTR | Blood | SEPT2 | 0.18 | 0.10 | enet | 34 | 0.14 | 1.0e-43 | 3.3 | 5.4 | 7.8e-08 | -0.13 | 1.00 | 0.00 | TRUE |
| 9 | YFS | Blood | PASK | 0.31 | 0.46 | lasso | 11 | 0.48 | 1.8e-181 | 4.8 | -5.2 | 1.8e-07 | -0.01 | 1.00 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C2orf54 | 0.09 | 0.10 | lasso | 3 | 0.10 | 3.1e-19 | -5.5 | 5.5 | 3.5e-08 | -0.07 | 0.12 | 0.88 | FALSE |
| 11 | The Cancer Genome Atlas | Colon Adenocarcinoma | C2orf54 | 0.08 | 0.03 | lasso | 1 | 0.02 | 2.1e-02 | -5.5 | 5.5 | 4.6e-08 | -0.07 | 0.05 | 0.70 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C2orf54 | 0.18 | 0.23 | lasso | 4 | 0.22 | 1.4e-24 | -5.5 | 5.4 | 6.6e-08 | -0.07 | 0.13 | 0.87 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C2orf54 | 0.33 | 0.27 | lasso | 2 | 0.27 | 1.4e-15 | -5.5 | 5.7 | 9.3e-09 | -0.06 | 0.14 | 0.86 | TRUE |
| 14 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | C2orf54 | 0.29 | 0.31 | enet | 6 | 0.32 | 1.5e-15 | -5.1 | 5.5 | 3.5e-08 | -0.07 | 0.29 | 0.71 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SEPT2 | 0.14 | 0.00 | enet | 7 | 0.02 | 7.7e-04 | 2.8 | 5.2 | 2.3e-07 | -0.09 | 0.04 | 0.66 | FALSE |
| 16 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | BOK | 0.19 | -0.01 | lasso | 4 | 0.01 | 1.2e-01 | -8.8 | -6.9 | 5.2e-12 | 0.86 | 0.00 | 0.76 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | BOK | 0.07 | 0.04 | lasso | 5 | 0.03 | 1.8e-04 | 7.5 | -8.1 | 5.0e-16 | 0.76 | 0.01 | 0.97 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C2orf54 | 0.41 | 0.37 | lasso | 2 | 0.40 | 1.1e-44 | -5.5 | 5.3 | 8.6e-08 | -0.07 | 0.16 | 0.84 | FALSE |