Hub : Genes

MLF1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0400	0.0210	1.6e-02	0.004	0.008	0.010	0.010	0.014	9.1e-02	3.2e-02	2.1e-02	2.0e-02	6.7e-03
2	GTEx	Adipose Subcutaneous	0.0540	0.0230	2.0e-03	0.008	NA	0.029	NA	0.024	6.3e-02	NA	1.9e-03	NA	4.5e-03
3	GTEx	Adrenal Gland	0.1488	0.0650	2.2e-03	0.014	NA	-0.001	NA	0.019	9.7e-02	NA	3.4e-01	NA	6.7e-02
4	GTEx	Esophagus Mucosa	0.2250	0.0470	1.6e-15	0.299	NA	0.263	NA	0.285	2.6e-20	NA	1.0e-17	NA	2.6e-19
5	GTEx	Heart Atrial Appendage	0.1940	0.0610	4.6e-06	0.138	NA	0.115	NA	0.078	9.6e-07	NA	7.5e-06	NA	2.2e-04
6	GTEx	Heart Left Ventricle	0.2605	0.0622	8.5e-12	0.245	NA	0.236	NA	0.281	2.8e-13	NA	7.9e-13	NA	2.5e-15
7	GTEx	Lung	0.0775	0.0277	7.9e-05	0.067	NA	0.065	NA	0.055	7.3e-06	NA	1.1e-05	NA	4.5e-05
8	GTEx	Muscle Skeletal	0.1086	0.0340	3.0e-06	0.040	NA	0.092	NA	0.086	7.9e-05	NA	2.7e-09	NA	8.7e-09
9	METSIM	Adipose	0.0861	0.0293	1.9e-06	0.000	0.040	0.038	0.040	0.022	2.8e-01	1.1e-06	2.0e-06	1.1e-06	2.7e-04
10	YFS	Blood	0.0304	0.0112	7.3e-05	0.007	0.016	0.016	0.016	0.008	2.2e-03	5.1e-06	4.3e-06	4.6e-06	1.0e-03
11	TCGA	Colon Adenocarcinoma	0.0640	0.0400	6.2e-03	0.037	0.041	0.013	NA	0.027	3.2e-03	2.0e-03	5.6e-02	NA	1.0e-02
12	TCGA	Esophageal Carcinoma	0.1770	0.1050	2.9e-03	0.009	0.078	0.135	NA	0.083	1.6e-01	1.9e-03	4.6e-05	NA	1.3e-03
13	TCGA	Head and Neck Squamous Cell Carcinoma	0.0325	0.0191	6.0e-03	0.005	0.012	0.012	NA	0.006	9.0e-02	1.3e-02	1.6e-02	NA	5.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	1.9	3.0	8.6	2.9	-1.5	-1.4	1.8	-1.8	-1.8	-1.3	-2.1	0.1	1.1	1.1	2.3	1.7
Bipolar Disorder or Schizophrenia	0.6	1.6	4.1	1.4	-1.4	-0.7	1.2	-1.4	-0.9	-1.1	-1.1	1.0	0.6	1.6	2.0	1.2
Depressed Affect (Nagel 2018)	1.9	3.9	10.4	1.0	2.4	3.2	-1.2	2.8	2.8	2.4	-1.3	1.4	-0.4	0.5	-0.0	2.6
Depression (Nagel 2018)	1.8	2.7	8.0	-0.6	1.5	2.1	-0.6	1.8	2.4	1.9	-0.0	2.8	0.5	0.7	-0.1	2.6
Intelligence (Savage-Jansen 2018)	0.4	1.3	4.1	-0.8	2.0	0.8	-0.3	0.7	0.3	1.2	1.1	-1.5	-2.0	-0.1	-1.3	-0.2
Neuroticism (Nagel 2018)	1.6	3.7	10.6	0.9	1.7	3.2	-0.7	3.1	3.3	1.9	-0.7	1.4	0.4	1.3	0.0	2.2
Schizophrenia (2018)	0.2	0.3	1.3	-0.6	-0.5	0.2	0.1	-0.3	0.2	-0.4	0.3	1.1	-0.2	1.1	0.8	0.2
Schizophrenia vs Biploar Disorder	1.7	2.3	4.4	-1.9	1.0	1.7	-1.9	1.5	1.9	0.6	1.5	1.8	-2.1	-0.7	-0.8	-1.0
Worry (Nagel 2018)	1.5	3.1	10.2	-1.1	1.2	3.0	-1.2	3.2	3.1	1.8	-0.2	1.2	0.9	0.8	-0.5	1.0
Alzheimer’s Disease (in mother)	0.6	0.7	2.6	0.2	-0.1	0.7	-1.6	0.1	0.7	-0.3	-0.7	-0.8	-0.3	-1.6	-0.4	-1.4
Alzheimer’s Disease (in father)	0.2	0.2	1.3	0.2	0.4	0.3	-0.3	1.1	0.8	0.4	-0.2	0.2	-0.2	-0.3	-0.4	0.5
Alzheimer’s Disease (including proxy)	0.6	0.9	3.2	-0.2	-0.0	1.1	-1.8	1.0	1.5	0.1	-0.4	-0.3	0.2	-1.5	-0.8	-0.9
Crohns Disease (2017)	0.8	1.7	4.4	-1.0	-0.6	0.9	-1.8	1.8	1.8	0.5	0.1	1.6	0.5	-1.6	-2.1	-0.3
Irritable Bowel Disease (IBD)	1.5	3.7	9.0	-1.2	0.3	1.3	-2.8	2.9	2.5	1.4	0.7	2.4	-0.2	-3.0	-2.3	-0.1
Ulcerative Colitis (UC)	1.4	2.6	6.5	-0.7	1.2	0.8	-2.0	2.4	1.6	1.7	0.7	2.2	-1.3	-2.5	-1.3	0.5
Major Depression (MDD)	0.5	0.7	3.3	0.3	0.9	0.7	0.6	-0.2	0.3	0.7	0.1	-0.8	1.8	1.2	-0.3	0.8
Reaction Time	0.7	1.4	4.8	1.2	-1.0	-0.0	0.9	-0.4	-0.3	-0.8	-1.1	1.2	2.2	0.3	2.2	1.2
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.3	0.0	1.1	0.7	-0.2	0.9	0.7	0.7	0.0	-0.4	0.2	0.2	-0.2	0.7
Breast Cancer	1.7	4.0	13.1	-0.4	0.0	1.6	-2.7	2.3	1.6	1.6	-2.7	2.1	-1.9	-3.6	-0.0	1.7
Ovarian Cancer	1.4	1.8	5.5	0.3	1.8	1.4	-1.3	1.6	1.2	1.6	-2.4	-0.2	0.5	-2.0	-0.6	0.5
Prostate Cancer	0.4	0.6	2.5	-0.8	1.4	0.6	-0.7	0.8	0.3	1.6	0.3	-0.5	-0.3	-0.2	-0.4	0.1
Age at First Birth	0.8	1.1	4.7	-0.0	-0.4	-1.1	-1.0	-0.7	-0.6	-1.3	-1.1	-0.9	1.0	-1.3	-0.2	-2.2
Bipolar Disorder (2011)	0.5	0.4	1.6	0.2	-0.7	-1.3	0.0	-1.2	-0.9	-0.1	-0.4	-0.8	0.1	-0.5	0.1	-0.1
Body Mass Index (BMI) (2010)	1.8	2.5	10.9	-1.6	-0.2	-0.1	-2.4	1.2	1.2	0.0	-1.8	-0.0	0.3	-3.3	-1.7	-2.0
Coronary Artery Disease (CAD)	1.3	1.6	5.7	1.3	-2.4	-1.0	1.0	-1.3	-1.1	-2.0	-0.1	0.3	1.5	0.8	0.9	-0.3
Crohns Disease (2012)	0.5	0.8	2.8	-0.7	-1.7	-0.3	0.2	0.0	0.1	-0.7	1.1	0.4	1.2	0.3	-1.4	-1.0
Mean Putamen Volume	1.4	1.6	7.1	1.0	0.1	-1.7	0.4	-0.8	-0.8	0.1	-2.7	0.8	-0.0	-0.2	1.4	2.3
Fasting Glucose	0.6	0.8	3.5	-1.9	-0.3	0.0	-0.8	0.1	0.3	0.1	1.6	-0.1	0.2	-0.1	-1.1	-1.3
HbA1C	1.2	1.3	4.7	-1.0	1.8	1.3	-1.0	1.1	0.1	2.2	0.2	-0.1	-1.3	-0.1	-1.6	0.6
HDL Cholesterol	0.4	0.7	1.7	-0.0	0.1	-0.2	1.1	-0.4	-0.5	0.4	1.0	1.3	-0.2	1.2	1.1	1.3
LDL Cholesterol	0.9	1.5	4.1	-1.3	1.8	2.0	-1.0	1.5	0.9	1.9	0.2	0.4	-0.7	-0.5	-1.3	0.1
Lupus	0.3	0.5	2.1	-1.2	0.4	0.6	-0.7	0.6	0.1	1.5	-0.6	0.6	0.7	-0.0	-0.3	0.5
Neuroticism (2016)	0.8	1.1	4.8	1.3	0.8	1.2	-0.1	0.8	0.9	0.9	-0.8	1.7	-0.1	0.3	0.2	2.2
Primary Biliary Cirrhosis	0.8	1.2	2.6	0.9	1.0	1.3	-0.9	1.6	1.1	1.4	-1.3	1.1	0.7	-0.7	-1.1	0.9
Rheumatoid Arthritis	0.3	0.4	0.9	-0.6	0.5	-0.8	0.9	-0.9	-0.7	-0.4	-0.4	0.2	0.7	0.8	0.7	0.1
Schizophrenia (2014)	0.2	0.4	1.6	-0.9	-0.6	-0.3	0.3	-0.4	0.1	-0.7	0.6	1.2	-0.3	1.1	0.2	0.1
Triglycerides	1.8	3.0	6.9	-1.5	1.7	1.7	-2.3	2.0	1.6	2.6	-1.0	1.0	-0.9	-2.2	-2.2	0.3
Type 2 Diabetes (T2D) (2012)	0.9	1.0	3.9	-0.7	-0.3	0.9	-1.1	1.3	2.0	-0.6	1.0	0.7	1.1	-0.2	-0.9	-1.0
Ulcerative Colitis	0.7	1.0	5.8	-0.9	-0.4	-1.0	-1.3	0.8	0.1	0.3	-0.4	1.5	-0.3	-2.4	0.2	-0.1
Blood Eosinophil Count	0.5	3.7	9.2	-1.0	1.5	2.8	-2.2	2.8	3.0	1.8	-0.2	2.4	-1.2	-1.5	-1.4	1.1
Blood Platelet Count	0.3	3.1	9.5	1.0	-2.0	-0.4	1.3	-0.3	-0.5	-0.9	-1.8	3.0	1.8	0.8	3.1	2.5
Blood Red Count	0.1	1.4	8.0	-1.8	-0.8	-0.3	-0.4	-1.0	-0.1	-1.5	0.4	-1.3	1.0	-0.3	-0.6	-2.8
Blood White Count	0.2	1.8	4.2	2.0	-0.9	-0.4	1.5	-0.9	-1.2	-0.7	-0.2	2.0	0.6	1.3	2.0	1.7
Heel T-Score	0.1	0.9	4.7	-1.7	0.6	0.8	-0.5	1.1	0.2	-0.2	-2.2	-0.4	0.8	-0.7	-0.7	-0.3
BMI	0.8	4.5	16.7	-2.9	-1.1	-0.4	-3.0	1.4	1.1	-0.9	0.2	0.3	-2.4	-4.1	-1.0	-3.5
Height	1.2	24.0	96.2	1.4	-0.8	-1.9	7.0	-6.5	-5.2	-1.9	3.1	-5.9	6.2	9.8	2.3	1.0
Waist Hip Ratio (WHR)	0.5	2.3	13.2	1.6	1.2	1.0	1.6	0.0	-0.5	1.6	-0.4	1.5	-0.1	1.9	0.6	3.6
Systolic Blood Pressure	1.5	7.7	22.7	-2.9	0.6	2.9	-3.7	4.4	4.8	0.4	1.3	3.1	1.0	-2.2	-2.4	-2.0
Smoking Status	1.0	2.4	11.2	-0.3	1.9	1.0	1.4	1.2	0.5	1.6	0.0	2.4	-0.5	1.7	-0.1	3.4
Allergy or Eczema	0.1	0.3	0.8	-0.9	0.1	-0.6	-0.7	0.5	0.5	0.5	-0.2	-0.7	-0.7	-0.2	-0.2	-0.6
Cardiovascular Disease	1.9	6.4	15.2	-2.3	-0.5	3.0	-3.6	3.9	3.9	0.8	-1.2	3.1	1.1	-3.2	-1.3	0.2
Hypothyroidism (self reported)	0.6	1.4	3.3	-1.6	0.4	1.5	-1.2	1.1	1.8	-0.6	1.2	-0.0	-0.4	-0.5	-1.6	-1.6
Respiratory disease	0.7	1.5	5.3	-0.7	-0.2	0.2	-0.9	1.9	1.6	0.4	0.5	1.9	-2.3	-1.1	-0.1	0.8
Type 2 Diabetes (T2D) (2018)	1.1	2.1	5.1	-0.3	0.1	2.1	-1.7	2.2	2.2	0.2	-1.9	1.0	-0.5	-2.1	0.3	0.7
Lung FEV1/FVC ratio	1.1	5.8	18.7	-1.1	0.9	2.8	-4.3	3.1	3.1	1.9	0.5	0.9	-1.0	-3.8	-2.1	-1.5
Lung FVC	4.8	24.2	50.1	6.3	-2.2	-4.5	7.1	-7.1	-6.7	-1.5	-3.5	0.2	0.2	5.7	5.0	5.7
Neuroticism	1.3	3.2	8.2	1.0	1.2	2.7	-0.1	2.7	2.6	1.5	-1.2	2.0	0.7	1.2	0.6	2.9
Chronotype (morning person)	0.8	1.7	5.7	0.6	-0.0	0.8	1.7	0.2	0.5	0.8	1.7	1.6	1.4	2.4	0.1	2.1
Hair Pigment	0.1	1.5	3.8	-1.1	1.6	1.4	-1.1	1.3	1.0	2.0	-0.4	1.8	-0.3	-1.0	-0.9	0.9
Tanning	0.0	0.6	1.5	1.1	0.1	-0.9	-0.1	-0.5	-0.9	-0.0	-1.2	-0.6	-1.1	-1.2	0.3	-0.1
Hand grip strength (left)	2.5	6.7	12.0	3.1	-1.6	-3.2	3.5	-3.0	-3.4	-2.0	-1.4	-1.6	1.7	2.6	3.3	1.7
Number of treatments/medications taken	2.7	4.9	10.9	-1.5	1.5	2.5	-2.4	2.9	2.9	2.5	-0.8	3.3	-1.6	-2.1	-1.0	2.1
Average weekly spirits intake	0.9	1.1	3.6	-1.1	0.4	0.9	-1.7	0.3	0.8	0.4	0.7	-0.4	-0.4	-1.8	-0.4	-1.9
Sensitivity / hurt feelings	1.6	2.7	8.7	-0.5	1.8	3.0	-1.6	2.4	2.7	1.9	0.4	1.4	0.1	0.2	-0.7	0.9
Frequency of depressed mood in last 2 weeks	1.4	2.0	5.5	-0.5	1.0	1.8	-0.7	1.8	2.3	1.9	0.5	1.8	-0.7	0.6	-0.8	2.1
Hearing difficulty/problems: Yes	0.3	0.5	1.8	1.3	0.3	0.9	0.8	0.4	0.4	-0.2	0.5	0.0	-0.8	0.9	0.9	0.7
Relative age of first facial hair	0.2	0.4	1.5	-0.2	0.4	-0.4	-0.1	0.1	-0.1	-0.1	-1.2	-0.6	1.0	-1.1	0.7	0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	3.7	-0.7	0.5	0.3	-0.0	-0.0	0.4	0.2	1.9	-0.6	-1.3	1.4	-0.5	-1.0
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.7	-1.1	0.8	1.7	0.1	0.7	0.8	1.0	1.2	0.9	0.0	0.9	-0.7	0.7
Ever had hysterectomy (womb removed)	0.7	0.7	2.0	-0.3	-0.3	-0.7	-0.5	-0.7	-1.1	-0.7	-1.1	-1.4	-0.8	-1.2	0.4	-1.1
Systolic blood pressure, automated reading	1.5	4.3	14.5	-2.5	-1.1	1.3	-2.3	1.6	2.2	-1.7	2.2	1.3	2.1	-1.6	-1.7	-3.8
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.6	0.4	0.3	1.1	-0.5	1.4	1.6	0.0	0.8	0.8	-0.1	-0.5	0.4	-0.0
Angina	0.6	0.7	4.1	0.1	-0.6	0.6	-0.9	0.6	0.5	-0.2	0.7	-0.1	-2.0	-1.1	-0.5	-1.0
Medication for hormone replacement therapy	1.2	1.4	4.2	-1.8	1.3	1.3	-0.6	0.9	1.1	0.7	1.6	-0.9	-0.2	0.7	-2.0	-0.8
Vitamin and mineral supplements	0.2	0.2	0.9	0.9	-0.2	0.6	-0.2	0.4	0.6	0.2	-0.1	0.1	0.4	-0.3	-0.5	0.7
Supplements: Zinc	1.5	1.6	5.6	-0.2	-0.8	-0.4	1.8	-1.1	-0.3	-1.4	-0.4	0.2	2.4	2.2	1.8	0.1
Medication: Co-codamol	0.9	1.0	2.7	-1.1	1.3	1.0	-1.2	1.1	1.1	1.7	-0.4	0.1	0.2	-1.0	-1.2	0.0
Medication: Metformin	1.9	2.7	6.8	-0.2	0.3	2.6	-2.4	2.2	2.6	0.3	-1.4	1.3	-1.3	-2.2	0.6	-0.0
Diabetes (father)	0.4	0.5	2.1	-0.6	0.3	1.5	-0.8	0.3	0.8	1.1	-0.3	-0.9	0.7	0.0	-0.5	-0.2
Diabetes (mother)	0.6	0.7	3.0	-1.1	-1.5	-0.1	-0.4	0.4	0.6	-0.9	0.5	0.3	-0.1	-1.0	-1.7	-0.6
Severe depression (siblings)	1.6	1.8	3.8	-0.7	0.3	0.8	-1.6	1.7	1.5	1.8	-1.0	1.9	-0.2	-1.2	-0.7	1.9
Pack years adult smoking proportion	0.4	0.5	1.6	0.5	1.1	0.7	0.6	-0.2	-0.5	1.3	0.3	-0.5	-0.4	1.2	-0.2	0.9
Impedance of leg (right)	0.4	2.0	6.9	-1.4	2.6	1.0	-0.1	-0.7	-0.4	1.2	1.0	-2.0	1.0	0.7	-2.6	-1.3
Leg fat-free mass (left)	0.2	1.1	3.9	0.0	-2.0	-0.6	1.2	-0.6	-0.5	-1.3	0.3	0.1	1.0	1.3	1.8	0.7
Trunk fat percentage	0.4	1.6	5.6	-2.4	-0.4	0.3	-1.2	-0.0	-0.1	-0.2	0.4	-0.4	-2.2	-1.7	-0.6	-2.2
Hand grip strength (right)	2.8	7.6	16.2	4.0	-1.5	-3.2	3.5	-3.4	-3.5	-2.2	-1.3	-2.2	1.6	2.8	3.0	1.7
Townsend deprivation index at recruitment	0.7	1.0	4.0	-0.1	1.1	0.4	0.3	0.9	0.6	0.7	2.0	-0.0	-2.0	0.5	-1.4	-0.4
Current tobacco smoking	1.5	2.5	7.0	-0.1	2.4	1.3	-0.2	1.7	1.4	2.6	1.0	2.2	-0.6	0.4	-1.7	2.1
Average weekly fortified wine intake	0.4	0.5	1.4	-0.7	-0.1	1.2	-1.2	0.5	0.6	0.3	0.8	-0.0	0.6	-0.6	-0.6	-0.7
Maternal smoking around birth	0.8	1.2	6.5	1.1	1.0	0.6	0.6	0.7	0.6	1.2	0.8	1.4	-0.8	0.8	0.6	2.5
Fed-up feelings	2.4	4.3	9.8	0.7	2.7	3.1	-0.2	2.7	2.8	2.7	0.8	1.8	-1.2	1.4	-0.9	2.8
Frequency of unenthusiasm / disinterest in last 2 weeks	3.5	4.7	12.7	-1.4	1.6	2.6	-1.1	2.8	3.3	2.5	0.3	3.6	-0.5	0.4	-1.3	2.9
Relative age voice broke	0.9	1.4	9.1	0.5	0.1	-0.4	1.3	-1.2	-0.5	-0.9	-0.9	-1.3	3.0	1.2	1.1	-0.1
Taking other prescription medications	1.4	2.1	4.3	-1.0	1.2	1.6	-2.0	2.1	2.0	1.8	-0.6	1.7	-0.6	-1.4	-0.8	1.0
Age when periods started (menarche)	0.1	0.3	1.2	0.4	-0.1	-0.5	0.5	-0.3	-0.4	0.1	0.8	0.3	-1.1	0.6	-1.1	0.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.1	-1.0	-0.3	-0.4	-0.9	-0.1	-0.7	0.3	1.1	-1.3	-1.1	-1.1	-0.7	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	5.4	-1.2	-0.8	-1.1	-0.0	-0.1	-0.9	-0.5	-2.3	0.5	1.3	-0.9	0.3	0.2
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	5.1	-0.7	2.3	0.7	-1.5	1.1	0.6	1.4	0.4	-0.3	-1.7	-1.5	-0.9	-0.4
Qualifications: CSEs or equivalent	2.7	3.6	8.4	-0.6	1.5	1.7	-2.7	2.9	2.7	1.8	-0.6	1.3	-0.6	-2.6	-2.5	-0.1
Serious illness, injury or assault to yourself	0.8	1.0	2.8	1.4	0.0	0.0	1.4	0.1	-0.4	0.3	0.9	0.9	-1.7	1.1	0.5	1.6
High blood pressure	1.9	5.3	10.0	-3.2	-1.4	2.1	-3.1	3.1	3.1	-0.6	-0.7	2.7	1.9	-3.1	-1.0	-0.8
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	-0.1	0.3	-0.3	-0.3	0.6	0.4	0.5	-0.6	-0.7	-0.5	0.0	0.2	-0.3
Multivitamins +/- minerals	0.3	0.4	1.5	-0.4	0.8	0.6	-0.8	0.1	-0.1	0.8	-0.1	-0.7	-1.2	-0.4	-0.1	-0.5
Stomach or abdominal pain in last month	2.9	3.7	10.8	-1.5	-0.4	2.3	-1.9	3.3	3.0	1.3	0.0	3.1	-0.7	-1.2	-0.9	1.4
Supplements: Glucosamine	0.4	0.5	1.6	0.4	-0.2	-1.1	-0.2	-0.7	-1.3	0.2	-0.3	-0.6	-0.3	-0.9	1.1	-0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.4	-1.2	-0.3	0.1	-0.7	0.7	0.7	0.1	0.6	-0.2	-0.8	-0.3	-0.6	-0.5
Medication: Atenolol	1.2	1.5	5.1	-2.2	-0.2	0.9	-1.0	1.2	1.3	1.2	1.6	2.0	0.1	-0.4	-0.8	0.6
Medication: Levothyroxine sodium	0.2	0.3	0.8	-0.0	0.7	0.4	0.5	0.1	0.3	-0.6	0.6	-0.6	-0.6	0.9	-0.8	-0.3
Sitting height	1.0	7.3	24.2	0.8	-1.4	-1.6	3.7	-3.8	-2.7	-1.6	0.6	-2.4	3.9	4.9	2.2	1.4
Chronic bronchitis/emphysema (father)	0.4	0.5	2.7	-0.0	-0.3	-0.1	0.9	-0.5	-0.5	-0.2	0.8	-0.6	-1.7	0.6	0.5	0.7
High blood pressure (mother)	2.4	3.4	8.2	-1.8	-0.1	1.9	-2.7	2.6	2.9	0.3	-0.3	1.9	1.0	-2.2	-2.3	-0.7
Body mass index (BMI)	0.7	2.8	11.4	-1.7	-2.4	-0.6	-2.0	0.4	0.2	-1.3	-0.8	0.7	-2.1	-3.4	0.2	-2.1
Impedance of leg (left)	0.4	2.1	8.5	-1.1	2.9	1.0	0.2	-0.7	-0.4	1.1	0.9	-2.3	0.9	1.1	-2.4	-1.2
Leg predicted mass (left)	0.2	1.1	3.9	0.0	-2.0	-0.6	1.2	-0.7	-0.5	-1.4	0.4	0.0	1.1	1.4	1.8	0.6
Trunk fat mass	0.3	1.1	3.8	-1.9	-1.1	-0.3	-0.6	-0.6	-0.7	-0.8	0.4	-0.8	-1.5	-1.1	0.1	-1.9
Waist circumference	0.2	0.8	2.5	-1.4	-1.6	0.0	-0.8	0.2	0.1	-0.7	-0.4	0.5	-1.1	-1.5	0.6	-1.0
Number of incorrect matches in round	0.8	1.4	2.9	-0.9	0.9	1.6	-1.7	1.5	1.5	0.9	-0.1	1.0	0.3	-0.9	-1.6	-1.0
Past tobacco smoking	1.3	2.4	11.5	0.0	-0.9	0.2	-1.9	-0.5	0.5	-0.3	1.8	-2.0	1.4	-1.4	-1.7	-3.4
Alcohol usually taken with meals	0.9	1.4	4.5	-1.2	0.3	0.2	-1.6	-0.2	0.3	-0.3	-0.8	-1.9	1.0	-1.8	-0.7	-2.1
Nervous feelings	0.5	1.0	3.0	-0.1	0.7	1.4	-0.7	1.7	1.7	0.9	-0.9	1.1	0.8	-0.0	-0.4	0.8
Frequency of tenseness / restlessness in last 2 weeks	2.8	4.3	14.3	0.6	0.9	2.1	-1.5	2.7	2.9	2.7	0.7	3.8	-1.1	-0.8	-0.5	3.0
Hearing difficulty/problems with background noise	1.4	2.2	7.4	1.9	-1.2	-0.4	1.8	-0.8	-0.9	-1.6	-1.4	0.8	0.5	1.2	2.7	2.2
Hair/balding pattern: Pattern 2	1.1	1.4	6.8	-0.6	-0.4	-0.6	1.0	-1.6	-0.8	-1.4	0.1	-1.1	2.6	1.4	0.8	-0.7
Had menopause	1.4	1.8	4.7	-0.4	-1.6	-1.0	1.6	-2.2	-2.0	-1.5	0.5	-0.9	0.0	1.5	1.6	-0.2
Had other major operations	0.7	0.8	2.2	-0.4	-1.5	-0.3	-0.9	0.3	0.1	-0.3	0.9	1.0	-0.5	-1.5	-1.3	-0.9
Forced vital capacity (FVC)	4.1	15.8	44.4	4.0	-0.4	-2.8	6.7	-5.0	-4.5	-0.5	-0.8	-0.8	2.3	6.7	3.5	5.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.8	-1.3	-0.8	-1.2	0.3	0.1	-0.7	-0.7	-1.3	0.4	0.8	-0.6	0.2	0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	5.0	-0.3	0.0	0.1	-0.3	0.4	-0.0	0.7	-0.9	1.4	-2.2	-0.6	0.2	1.0
Qualifications: None of the above	0.6	1.3	4.0	-1.6	0.4	0.9	0.6	0.5	0.0	1.1	2.0	1.6	-1.4	0.9	-0.9	0.8
Financial difficulties in last 2 years	1.8	2.4	10.1	0.4	0.7	0.1	2.5	-0.3	-0.3	0.5	2.9	0.6	-0.7	3.2	0.6	1.9
Mouth/teeth dental problems	0.6	0.9	3.0	-0.6	-1.3	-1.6	-1.1	-0.7	-0.2	0.1	-0.1	-0.7	-0.2	-1.1	-0.6	-1.7
Heart attack	1.3	1.6	3.4	-0.9	0.7	1.2	-1.1	1.8	1.0	1.8	-0.9	1.0	-1.8	-1.3	-0.0	1.6
Allergy	0.4	0.9	5.1	0.7	-0.5	0.3	1.2	-1.0	-0.5	-0.9	0.4	0.3	2.3	0.8	0.7	0.8
Pain all over the body in last month	0.8	0.9	3.1	0.5	0.4	1.6	0.8	0.4	0.7	0.2	-0.0	1.0	1.4	1.8	-0.0	1.2
Diabetes (self-reported)	3.2	4.9	13.8	0.2	0.4	2.7	-3.1	3.3	3.3	1.2	-1.8	2.2	-1.0	-3.7	0.1	0.8
Hayfever/allergic rhinitis (self-reported)	0.9	1.3	3.1	-0.7	0.5	1.3	-1.8	1.5	1.7	1.6	0.7	-0.1	-0.5	-0.8	-1.2	-0.3
Medication: Ramipril	0.6	0.8	2.3	0.3	-1.5	-0.6	-0.9	0.4	0.1	-0.3	-1.2	1.5	-0.6	-1.1	1.1	0.6
Medication: Simvastatin	0.9	1.3	4.0	-0.6	-1.3	1.2	-1.3	1.4	1.6	-0.4	-1.1	2.0	0.7	-1.1	-0.0	0.2
Fluid intelligence score	0.3	0.6	3.2	-0.2	0.1	-1.2	-0.3	-0.4	-0.9	-0.4	-0.7	-1.8	0.7	-0.9	0.3	-0.8
Illnesses of siblings	1.3	1.9	7.3	1.6	0.8	-0.3	1.7	-1.3	-1.1	-0.6	1.7	-2.0	0.4	2.7	-0.1	-0.7
Neuroticism score	2.1	4.4	11.2	0.5	1.8	3.3	-0.7	3.3	3.3	2.2	0.0	2.5	-0.3	0.9	-0.2	2.8
Weight	0.2	1.1	4.5	-1.4	-2.1	-0.7	0.2	-1.0	-0.9	-1.6	0.4	-0.7	0.1	-0.1	1.1	-1.2
Impedance of arm (right)	0.4	1.7	6.2	1.2	2.0	0.6	1.4	-0.6	-0.4	1.1	2.3	-0.9	0.3	2.5	-0.7	0.2
Arm fat percentage (right)	0.5	2.1	7.5	-1.3	-1.7	-0.5	-1.4	0.1	-0.1	-0.9	0.5	0.4	-2.6	-2.7	-0.0	-2.2
Trunk fat-free mass	0.4	2.0	6.0	0.3	-1.9	-0.9	1.5	-1.3	-1.1	-1.7	0.4	-0.9	2.4	1.9	1.7	0.4
Hip circumference	0.4	1.8	6.7	-1.5	-2.6	-1.1	-0.1	-0.8	-0.5	-2.1	0.8	-0.6	-0.1	-0.6	0.9	-2.5
Time employed in main current job	0.2	0.2	0.9	-0.5	1.0	0.2	-0.7	0.5	-0.1	0.6	0.2	-0.3	-0.3	-0.6	-0.0	0.0
Alcohol intake versus 10 years previously	2.3	3.4	7.3	1.3	0.6	1.9	-2.7	1.9	2.3	2.3	-0.4	2.5	-2.0	-2.4	-1.0	1.0
Father’s age at death	2.1	2.8	9.2	0.2	-1.4	-1.7	0.7	-2.3	-1.6	-2.0	0.5	-3.0	1.3	0.3	-0.2	-2.7
Worrier / anxious feelings	0.8	1.6	6.4	-0.5	0.0	1.7	-1.6	2.5	2.5	0.8	0.7	1.2	0.1	-0.2	-0.4	0.0
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	5.0	-0.7	1.5	1.4	-1.9	2.2	2.1	1.4	-0.1	1.9	-1.9	-1.0	-0.4	0.5
Falls in the last year	1.6	2.2	6.4	-0.9	0.3	1.0	-1.2	2.1	1.4	1.9	0.8	2.5	-2.2	-0.7	-1.0	1.3
Hair/balding pattern: Pattern 3	0.6	0.9	3.3	0.1	0.1	-0.4	1.4	-0.8	-0.8	0.3	0.5	-1.0	-1.8	1.5	0.6	0.8
Number of live births	0.1	0.2	0.7	0.4	-0.7	0.8	-0.5	0.1	0.3	0.4	-0.1	-0.1	-0.1	-0.7	0.3	0.1
Forced expiratory volume in 1-second (FEV1)	2.6	8.7	23.0	3.3	-0.3	-2.3	4.8	-4.0	-3.5	-0.5	-0.7	-1.1	2.3	4.6	2.4	3.5
Pulse rate	0.2	0.3	1.2	0.4	-0.5	0.4	0.3	-0.0	0.1	-0.3	0.7	-0.8	0.5	0.4	-0.1	-1.1
Happiness	0.8	1.0	3.2	0.4	-1.2	-0.5	0.9	-1.6	-0.9	-0.9	-0.7	0.3	0.8	0.9	1.8	0.7
Noisy workplace	0.5	0.6	2.8	-0.8	0.4	0.1	-0.3	0.9	0.7	0.2	-0.9	1.7	0.2	-0.6	-0.6	1.0
Qualifications: A levels/AS levels or equivalent	0.6	1.3	5.8	1.1	0.2	-1.2	-0.6	-0.3	-0.8	-0.0	-2.3	-1.4	-0.5	-2.4	0.4	-0.2
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	4.7	-0.3	-2.2	-1.1	0.8	-1.3	-1.1	-1.6	-0.4	1.1	1.3	0.5	1.3	-0.1
Mouth/teeth dental problems: Dentures	1.0	1.7	4.5	-0.0	2.1	1.6	1.1	0.9	0.4	1.0	1.9	1.7	-0.2	1.4	-1.1	1.4
Asthma	0.6	1.1	4.0	0.2	-0.9	-0.6	0.2	1.0	0.4	-0.2	-0.9	2.0	-1.8	-0.5	1.0	1.6
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	4.4	1.2	1.3	2.0	-1.0	1.7	2.1	1.5	0.1	1.6	-1.5	-1.2	-0.1	1.6
Medication: Cholesterol lowering	0.4	0.6	1.8	0.3	-0.4	1.4	-1.1	1.0	0.6	0.4	-0.2	0.5	-0.9	-1.2	-0.3	-0.2
Depression (self-reported)	0.3	0.3	1.2	0.4	0.2	0.1	0.9	-0.2	-0.3	-0.0	0.1	-0.7	0.9	1.1	0.7	0.1
Medication: Lansoprazole	0.7	0.8	4.2	0.3	2.0	1.3	-0.2	0.9	0.6	0.3	-0.1	-0.4	-1.4	-0.2	-0.6	-0.6
Prospective memory result	1.1	1.3	6.3	-0.3	-0.9	0.5	1.0	0.2	0.6	-0.4	0.1	2.5	1.7	1.6	-0.5	1.6
Lung cancer (father)	1.9	2.2	7.2	1.0	-2.0	-1.7	1.3	-1.5	-1.9	-0.9	-1.4	0.6	-0.8	0.7	2.7	1.5
Illnesses of mother	2.2	2.8	7.4	2.2	-0.6	-2.7	2.2	-1.8	-2.1	-0.6	-0.4	-0.5	0.4	1.4	2.5	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.7	8.5	19.0	4.3	-0.4	-2.1	4.4	-3.9	-3.2	-0.8	-1.0	-1.0	2.1	4.3	2.8	3.0
Pulse wave Arterial Stiffness index	0.3	0.4	1.5	-0.5	0.6	0.6	0.1	0.6	0.6	0.5	1.2	0.0	-0.4	0.6	-0.8	0.1
Impedance of arm (left)	0.4	1.7	6.4	0.5	2.5	1.0	0.8	-0.2	-0.0	1.5	1.9	-1.4	0.1	2.1	-1.1	0.1
Arm fat mass (right)	0.4	1.5	4.2	-1.5	-1.8	-0.5	-1.1	-0.2	-0.3	-1.2	0.2	-0.2	-1.8	-2.0	0.3	-2.0
Trunk predicted mass	0.4	2.2	6.2	0.4	-1.9	-0.9	1.7	-1.4	-1.2	-1.8	0.4	-1.0	2.5	2.0	1.8	0.5
Standing height	1.0	9.7	44.6	1.0	-0.0	-0.5	4.5	-3.1	-2.4	-1.0	2.3	-3.0	4.9	6.7	1.7	1.7
Length of working week for main job	1.9	2.1	6.4	-1.1	2.0	1.4	-0.9	1.4	1.3	1.3	2.0	-0.9	-1.0	0.2	-2.5	-1.0
Exposure to tobacco smoke at home	1.3	1.4	4.4	0.5	1.0	1.2	-0.5	1.2	0.9	1.8	-0.0	1.4	-1.6	-0.2	-1.0	2.1
Breastfed as a baby	0.7	0.9	4.1	1.1	0.1	-0.7	-0.0	-1.0	-0.9	-0.6	0.6	-2.0	-1.1	-0.3	-0.5	-1.4
Tense / ‘highly strung’	2.7	4.5	10.2	-1.5	1.1	3.2	-1.1	2.9	2.9	2.5	-1.2	3.0	1.1	0.6	-0.2	2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.4	18.6	1.3	1.2	0.5	3.3	-0.6	-0.0	0.1	1.8	0.3	0.7	4.3	0.9	2.5
Hair/balding pattern: Pattern 4	0.6	1.5	5.1	2.3	-0.2	1.2	0.6	1.1	0.9	-0.0	-0.2	2.1	1.7	0.6	-1.1	1.1
Birth weight of first child	0.4	0.7	2.0	0.1	0.7	-1.4	-0.0	-1.0	-0.8	0.4	-0.4	-1.4	0.9	-0.6	0.9	-0.5
Peak expiratory flow (PEF)	0.3	0.7	3.7	1.3	0.0	-0.5	0.3	-0.9	-0.5	-0.5	-0.5	-1.9	0.5	0.2	0.6	-0.7
Pulse wave reflection index	0.3	0.3	1.2	-0.7	0.6	-0.1	0.3	0.5	0.5	0.2	1.1	0.5	-0.1	0.9	0.1	0.4
Ever highly irritable/argumentative for 2 days	1.2	1.5	5.7	-1.3	0.9	1.2	0.2	1.1	1.2	1.6	-0.3	1.5	-1.3	0.4	-0.2	2.4
Loud music exposure frequency	2.0	2.2	12.2	1.9	-0.5	-0.1	0.9	0.1	-0.2	-0.1	-1.7	1.2	-0.8	1.1	3.5	2.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.4	0.3	1.2	0.6	-1.3	1.0	0.8	1.1	-1.6	-0.1	-0.1	-1.9	-0.6	0.5
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	0.4	0.8	1.1	0.2	0.2	0.4	-0.2	-1.0	-0.6	-0.1	0.7	-0.3	0.8
Blood clot in the leg (DVT)	0.7	0.9	2.6	-0.1	-0.9	-1.1	-0.3	-0.9	-1.2	-1.2	-0.6	-0.3	-1.6	-0.3	-0.4	-1.4
Medication: Paracetamol	1.1	1.8	3.9	1.0	1.0	1.4	-0.7	1.7	1.6	1.5	0.3	1.4	-2.0	-1.3	0.2	1.9
Headache pain in last month	6.3	10.8	26.2	-2.3	3.8	4.6	-3.6	4.8	5.1	3.8	2.3	1.7	-1.1	-1.1	-3.5	0.0
Medication for cholesterol, blood pressure or diabetes	1.4	2.2	6.3	0.3	0.1	-2.4	2.3	-2.5	-2.2	-0.5	-0.0	-1.0	0.5	1.9	1.0	0.6
Glaucoma (self-reported)	0.8	0.9	2.5	-0.2	-1.4	-1.6	-0.6	-0.3	-0.6	-0.8	0.7	-0.7	-0.7	-1.4	0.3	-1.5
Gout (self-reported)	0.6	0.8	2.7	0.7	-0.4	-1.5	0.9	-0.3	-0.7	-1.3	0.7	0.7	1.7	0.6	0.4	0.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.2	-0.3	0.5	1.1	0.2	0.5	1.0	-0.5	0.4	0.8	-0.5	0.5	-0.8	0.3
Medication: Amlodipine	0.9	1.3	7.2	-0.3	-1.6	0.1	-0.2	0.5	0.5	-0.7	-1.0	2.7	1.9	-0.3	0.5	0.9
Medication: Ventolin 100micrograms inhaler	1.2	1.5	4.8	-0.3	0.4	0.7	-2.0	1.1	1.2	1.3	-2.1	0.7	-1.1	-2.2	0.1	0.3
Birth weight	1.3	2.8	9.1	0.5	-0.5	-2.0	1.4	-1.9	-3.0	-0.9	-0.9	-2.7	-1.6	-0.0	1.9	-1.2
Chronic bronchitis/emphysema (mother)	0.8	0.9	3.2	-0.4	0.5	1.8	0.1	0.5	0.7	0.9	-0.9	1.6	1.4	0.3	-0.4	1.4
High blood pressure (siblings)	0.9	1.3	6.5	-1.2	-1.6	-0.3	-1.5	0.7	0.8	-0.6	-1.0	0.9	-0.6	-2.5	-0.1	-0.9
Forced vital capacity (FVC), Best measure	4.2	15.2	40.8	5.0	-0.7	-3.0	6.3	-4.9	-4.2	-1.3	-0.6	-1.0	2.3	6.4	3.6	4.4
Body fat percentage	0.5	2.1	6.3	-2.5	-0.9	0.1	-1.5	-0.0	-0.1	-0.5	0.3	-0.4	-2.3	-2.3	-0.6	-2.5
Leg fat percentage (right)	0.8	3.0	12.2	-2.9	-1.1	-0.1	-2.1	-0.1	-0.2	-0.6	-0.8	-0.3	-1.9	-3.5	-1.0	-2.7
Arm fat-free mass (right)	0.2	1.1	2.7	-0.9	-1.6	-0.4	0.9	-1.0	-0.7	-1.3	0.2	-1.0	1.6	1.2	1.2	0.0
Exposure to tobacco smoke outside home	0.9	1.1	4.5	0.5	-0.8	-0.6	0.3	0.6	0.1	0.4	-1.8	2.1	-1.0	-0.3	0.7	1.9
Comparative body size at age 10	0.7	1.9	11.0	-3.3	-0.9	-0.6	-1.0	0.3	0.1	-1.3	0.6	0.6	-0.9	-1.8	-0.6	-2.0
Number of full brothers	1.2	1.5	4.7	-1.7	0.4	0.4	-0.8	1.4	1.4	0.5	1.4	0.6	-2.2	-0.9	-1.6	-0.4
Worry too long after embarrassment	0.3	0.4	1.4	0.7	-0.1	0.8	0.1	0.6	0.8	0.0	0.6	1.2	0.6	0.8	0.8	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	8.1	0.9	-0.1	0.2	2.3	-0.3	0.1	-0.4	-0.2	1.3	0.8	2.9	1.3	2.2
Wheeze or whistling in the chest in last year	1.9	3.5	7.6	-1.6	0.8	0.9	-1.9	2.4	1.9	2.1	-1.7	2.8	-2.3	-2.3	0.3	1.7
Number of children fathered	0.9	1.0	3.7	-0.1	-0.0	0.2	-1.3	-0.0	-0.2	-0.6	-1.2	-1.6	0.9	-1.9	-0.4	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	7.0	2.6	-1.7	-1.3	2.2	-1.9	-2.0	-1.3	0.2	-0.1	0.7	1.6	1.4	0.9
Age at first live birth	1.3	2.3	5.5	-0.1	2.0	0.7	-2.3	1.2	1.2	1.5	0.7	-0.9	-1.2	-1.4	-2.4	-2.0
Pulse wave peak to peak time	0.4	0.4	1.7	0.5	-0.6	-0.7	-0.0	-0.8	-0.8	-0.4	-1.3	-0.3	0.7	-0.5	0.8	-0.1
Health satisfaction	0.9	1.2	2.9	0.1	-0.1	1.2	-1.3	0.9	1.0	1.0	-1.2	1.7	-0.8	-1.1	-0.4	1.7
Shortness of breath walking on level ground	2.0	2.3	9.8	-0.7	1.2	1.4	-1.5	1.7	1.3	1.9	-0.0	1.5	-3.1	-1.4	-1.0	1.0
Qualifications: College or University degree	1.5	4.8	16.9	1.4	-1.9	-2.6	1.1	-2.7	-2.6	-2.8	0.0	-4.1	0.6	0.6	1.8	-2.5
Eye problems/disorders: None of the above	0.1	0.1	0.6	-0.0	0.1	0.4	-0.1	-0.1	-0.1	0.8	-0.1	-0.4	0.2	0.6	0.3	0.3
Mouth/teeth dental problems: Loose teeth	1.7	2.0	10.2	-1.3	-0.9	-0.3	2.1	-1.1	-0.6	-1.7	2.0	-0.4	0.9	3.2	-0.2	-0.5
Emphysema/chronic bronchitis	0.7	0.8	1.7	-1.2	1.1	1.0	-1.2	0.7	0.6	1.2	-0.6	0.2	-1.3	-0.5	-0.3	0.1
Medication for pain relief, constipation, heartburn	2.1	3.6	7.4	-0.2	-1.5	-2.7	1.4	-1.7	-1.9	-2.7	0.1	-2.5	2.5	1.4	-0.2	-2.7
Neck or shoulder pain in last month	2.2	3.2	12.5	-0.2	2.6	2.1	-1.0	1.9	1.5	3.5	-0.3	1.1	-1.4	-0.7	-1.9	1.7
Medication: Blood pressure	1.6	2.8	8.1	-1.5	0.1	2.4	-2.0	2.8	2.8	0.8	1.1	2.2	0.6	-0.9	-0.9	0.2
Angina (self-reported)	0.6	0.8	5.4	0.3	-0.6	0.4	-0.9	0.4	0.3	-0.3	0.8	-0.4	-2.3	-1.1	-0.4	-1.1
Migraine (self-reported)	0.9	1.1	3.4	-1.8	0.6	1.3	-1.1	1.1	1.9	0.3	0.6	0.5	0.9	0.3	-1.0	-0.6
Medication: Ibuprofen	2.4	2.9	6.6	0.6	1.9	2.6	-1.4	2.2	2.5	2.1	0.4	2.1	-1.0	-1.2	-0.7	1.5
Medication: Allopurinol	0.2	0.3	1.1	-0.7	-0.0	-0.6	0.5	0.5	-0.1	-0.9	0.6	0.4	1.1	0.6	0.5	-0.1
Medication: Omeprazole	0.6	0.7	3.1	-1.1	0.9	1.4	-0.8	0.3	0.5	1.8	0.0	0.6	0.5	-0.2	-0.6	0.6
Medication: Seretide 50 evohaler	1.6	1.9	9.5	-0.6	0.5	0.1	-0.3	0.7	0.5	0.7	-3.1	1.6	-0.3	-0.4	2.1	2.3
Mean time to correctly identify matches	0.6	1.2	4.1	0.5	-0.9	-0.4	1.1	-1.1	-1.1	-0.8	-1.1	1.3	1.5	0.6	2.0	1.0
Heart disease (mother)	0.8	1.0	4.2	-0.7	0.9	1.4	-0.8	0.4	0.5	1.0	0.2	-0.3	-1.0	-0.0	-2.1	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	4.0	-0.4	-0.2	0.3	-1.2	1.1	0.4	-0.7	-0.5	-0.4	-0.7	-2.0	-1.1	-1.5
Whole body fat mass	0.3	1.4	4.2	-1.9	-1.5	-0.3	-0.8	-0.4	-0.6	-1.1	0.2	-0.7	-1.5	-1.6	0.1	-2.0
Leg fat mass (right)	0.4	1.6	4.5	-2.0	-1.8	-0.4	-1.0	-0.4	-0.4	-1.3	-0.3	-0.5	-1.2	-2.1	-0.1	-2.0
Arm predicted mass (right)	0.3	1.6	3.6	-0.5	-1.9	-1.0	1.3	-1.4	-1.1	-1.7	-0.1	-1.1	1.7	1.3	1.6	0.1
Pulse rate, automated reading	0.5	1.5	8.7	-1.2	-0.8	0.0	-1.2	0.3	0.6	-0.7	0.4	-1.0	2.1	-0.9	-0.6	-3.0
Alcohol intake frequency.	0.8	2.0	7.7	-1.1	-0.7	0.5	-2.6	1.4	1.9	0.3	0.4	0.9	-0.8	-2.8	-1.0	-1.0
Comparative height size at age 10	0.4	2.4	13.2	-1.0	0.2	-0.7	1.6	-1.2	-1.3	0.2	1.7	-1.6	2.2	3.6	0.4	0.4
Number of full sisters	0.7	0.9	3.3	-0.5	0.1	1.8	-1.3	0.9	1.6	0.6	0.2	0.7	0.6	-0.6	-1.2	0.2
Suffer from ‘nerves’	1.1	1.8	5.0	-1.4	1.3	2.2	-0.3	1.9	2.0	1.7	0.3	0.6	0.6	1.2	-0.7	1.1
Overall health rating	1.1	2.3	5.0	1.3	0.8	2.1	-0.8	2.2	2.2	1.3	0.9	1.8	-2.2	-0.2	-0.5	1.5
Chest pain or discomfort	1.6	2.3	6.0	-1.3	-0.3	1.2	-2.1	2.4	2.3	0.6	-1.3	1.8	-1.0	-1.8	-1.1	0.5
Had major operations	0.8	1.0	2.5	-0.5	0.8	0.5	-0.4	1.2	0.5	0.9	-1.6	1.1	-1.5	-0.2	0.7	1.5
Age at last live birth	1.4	2.0	4.7	0.6	2.1	1.3	-1.8	1.1	1.0	2.2	0.7	0.1	-1.7	-1.5	-1.7	-0.6
Family relationship satisfaction	0.9	1.1	5.2	-0.5	-0.9	-1.5	-0.3	-1.2	-1.3	-0.3	-2.3	-0.4	0.6	-1.0	0.8	0.1
Leg pain on walking	1.4	1.8	6.5	2.5	1.2	1.4	0.5	0.7	0.5	1.2	0.4	-0.1	-2.5	0.4	0.5	1.9
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	4.2	0.7	-0.2	0.4	0.0	1.1	1.4	0.0	-0.5	1.7	0.2	-0.3	0.1	2.1
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.5	-0.4	0.1	1.2	-0.5	0.7	0.7	1.0	-0.5	0.7	0.3	-0.7	-1.2	0.8
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.1	-0.3	1.1	0.6	-0.9	0.2	0.5	0.4	-1.0	-0.1	0.9	-0.5	-0.2	-1.0
Medication: Aspirin	2.3	3.0	6.2	-0.4	0.9	2.1	-1.8	2.4	2.1	2.5	-0.8	2.4	-1.7	-1.6	-0.3	1.6
Supplements: Vitamin C	0.5	0.6	2.9	-1.0	-0.3	-1.1	0.3	-0.4	-0.6	-0.6	-1.7	0.1	-0.1	-0.4	1.2	-0.0
Knee pain experienced in last month	1.0	1.5	9.0	-0.9	0.5	0.0	-1.4	0.5	0.1	1.5	-0.4	-0.2	-3.0	-1.9	-1.2	-0.0
Hypertension (Self-reported)	2.1	5.8	12.2	-3.5	-1.4	2.2	-3.2	3.4	3.5	-0.5	-0.5	3.0	1.5	-3.0	-0.9	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.8	-0.8	0.2	0.4	0.8	-0.2	0.2	-0.2	-0.3	0.6	0.3	0.9	0.5	0.7
Illnesses of father: Heart disease	1.3	1.8	6.6	1.9	-2.6	-1.3	0.9	-1.0	-0.7	-2.1	-0.2	0.9	-0.2	-0.0	1.8	0.3
Illnesses of siblings: Diabetes	1.4	1.8	10.9	-3.3	1.1	0.6	-1.6	1.1	1.2	1.3	-0.7	0.9	1.0	-0.9	-0.7	-0.3
Smoking status: Previous	1.3	2.0	7.5	-0.2	0.0	-0.8	1.7	-0.2	-1.0	-0.5	-2.5	1.0	-0.6	0.9	2.3	2.7
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	6.1	1.1	1.8	0.6	1.1	-0.4	-0.5	1.1	1.5	-2.5	0.3	2.0	-1.2	0.4
Whole body fat-free mass	0.3	1.7	4.0	0.2	-2.0	-0.7	1.4	-1.0	-0.9	-1.6	0.3	-0.5	2.0	1.7	1.8	0.5
Leg fat-free mass (right)	0.3	1.5	4.2	0.4	-2.0	-0.6	1.5	-0.7	-0.5	-1.5	0.4	-0.0	1.2	1.8	2.0	0.8
Arm fat percentage (left)	0.6	2.3	8.5	-1.8	-1.5	-0.4	-1.7	0.2	-0.1	-0.7	0.2	0.1	-2.9	-2.9	-0.2	-2.2
Average weekly red wine intake	0.9	1.3	3.6	-0.3	-1.0	-0.9	1.1	-1.8	-1.9	-1.1	1.1	-1.4	0.9	0.8	0.2	-1.2
Handedness (chirality/laterality): Left-handed	0.7	0.8	3.1	0.1	-1.2	-0.7	0.6	-0.1	-0.2	-0.0	0.2	1.5	1.8	1.1	1.0	0.7
Mood swings	1.9	3.5	8.3	0.3	1.9	2.7	-1.1	2.9	2.7	2.4	-0.9	1.3	-0.6	0.1	-1.0	2.7
Loneliness, isolation	2.0	2.7	7.8	1.4	2.7	2.1	-0.6	1.6	1.5	2.8	0.2	1.0	-2.1	0.6	-0.4	1.6
Long-standing illness, disability or infirmity	0.5	0.7	2.5	0.5	-0.6	-0.5	0.6	0.1	-0.2	-0.1	-0.7	1.6	-1.3	0.1	1.0	1.4
Ever had bowel cancer screening	1.2	1.4	3.6	0.4	1.3	1.4	-0.4	1.7	1.4	1.9	-0.3	1.6	0.6	-0.2	0.4	1.9
Diabetes diagnosed by doctor	2.0	3.3	7.9	0.2	0.2	2.1	-2.1	2.5	2.5	0.7	-2.0	2.4	-1.0	-2.8	1.1	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	2.4	0.4	-0.6	0.2	1.1	-0.5	-0.5	-0.8	0.9	-0.9	0.4	1.6	0.3	0.0
Friendships satisfaction	0.6	0.8	2.8	0.6	-0.7	-0.6	0.8	-1.0	-0.9	-0.3	-1.2	0.6	1.7	0.7	0.4	1.2
Qualifications: nursing, teaching	0.6	1.0	5.0	1.0	-0.7	-0.7	-0.7	-0.5	-0.4	-1.3	-0.4	-1.5	0.6	-0.6	0.3	-2.2
Commuting to job workplace: Walk	0.2	0.3	1.3	0.2	0.2	0.1	-0.3	1.1	0.8	-0.2	0.4	0.9	0.1	-0.1	-0.4	-0.5
Eye problems/disorders: Cataract	0.3	0.4	1.4	1.0	-0.1	0.2	0.2	0.2	0.4	-0.3	-0.7	1.1	0.4	-0.2	0.1	1.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	4.0	0.6	-1.0	-0.0	0.8	0.3	-0.3	-1.7	-0.4	-0.5	0.9	0.0	2.0	0.4
Medication for cholesterol	1.6	2.5	9.0	3.0	0.5	-1.5	2.0	-1.9	-2.1	0.0	0.7	-1.9	-0.1	1.3	1.6	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	4.5	0.8	0.4	1.3	0.8	0.3	0.3	0.4	0.4	1.3	0.1	2.1	-0.1	1.7
Back pain experienced in last month	0.2	0.4	0.9	-0.5	1.0	-0.2	0.1	-0.6	-0.9	0.6	-0.6	-0.4	-0.9	-0.5	-0.4	0.2
Mineral and other dietary supplements	1.0	1.4	5.2	-0.2	0.7	1.7	-1.4	1.8	2.3	0.4	0.9	0.2	0.1	-0.2	-1.8	-0.3
Breast cancer (self-reported)	0.4	0.5	2.5	1.6	0.1	0.3	0.8	-0.2	-0.1	-0.1	1.2	-0.6	1.1	0.7	0.1	0.3
Asthma (self-reported)	0.5	1.0	4.5	-0.0	-0.7	-0.3	-0.4	1.4	0.7	0.1	-0.5	1.7	-2.1	-0.9	0.5	1.1
Osteoporosis (self-reported)	0.8	0.9	2.7	0.8	-0.4	-0.7	1.6	-1.0	-1.2	-0.4	-0.6	0.5	-0.0	1.5	0.8	1.5
Osteoarthritis (self-reported)	0.1	0.2	0.7	0.6	-0.0	0.0	-0.4	-0.0	0.2	0.3	-0.1	-0.1	-0.4	-0.7	-0.4	-0.8
Medication: Aspirin	2.1	2.7	5.8	-0.5	0.8	1.8	-1.9	2.1	1.9	2.4	-0.5	2.1	-2.0	-1.9	-0.5	1.2
Medication: Gliclazide	0.7	0.8	3.9	1.2	-0.9	1.0	-0.2	0.4	0.6	-0.7	-2.0	0.1	0.8	-0.3	0.9	0.9
Illnesses of father: None of the above (group 1)	0.5	0.6	3.8	-0.0	0.9	-0.6	0.4	-0.4	-0.9	0.4	-0.4	-0.6	2.0	0.3	-1.1	-0.2
Smoking status: Current	1.3	2.1	5.7	0.0	2.1	0.8	0.1	1.4	0.9	2.4	1.4	2.1	-1.0	0.5	-1.8	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.3	11.4	3.4	-1.2	-2.2	3.0	-3.4	-2.7	-1.2	-1.3	-0.5	1.8	2.4	2.7	1.9
Whole body water mass	0.3	1.8	4.0	0.3	-2.0	-0.8	1.5	-1.1	-0.9	-1.7	0.4	-0.6	1.9	1.8	1.8	0.5
Leg predicted mass (right)	0.3	1.4	4.0	0.4	-2.0	-0.6	1.5	-0.6	-0.5	-1.5	0.4	-0.1	1.2	1.8	2.0	0.8
Arm fat mass (left)	0.4	1.4	3.4	-1.6	-1.9	-0.8	-0.8	-0.4	-0.5	-1.2	0.1	-0.3	-1.7	-1.8	0.4	-1.8
Number of self-reported non-cancer illnesses	3.5	6.1	12.1	-1.4	1.9	2.9	-3.5	3.2	2.4	3.5	-0.7	2.1	-2.0	-3.0	-2.5	0.8
Average weekly champagne plus white wine intake	0.4	0.5	1.4	-0.1	0.3	1.0	-0.7	1.0	1.2	0.4	-0.7	-0.9	-0.6	-0.1	0.7	-0.0
Miserableness	1.6	2.8	6.4	1.5	1.5	2.5	-0.7	2.4	2.4	1.7	-0.0	1.1	-1.9	0.3	-0.3	2.4
Guilty feelings	0.8	1.2	5.3	0.4	0.2	0.8	1.3	0.4	0.4	0.3	0.9	0.6	2.1	2.3	0.4	1.2
Wears glasses or contact lenses	0.3	0.3	1.5	-0.0	-0.6	0.8	-0.0	-0.5	0.2	0.0	1.2	-0.3	0.3	0.5	-0.8	-0.6
Ever taken oral contraceptive pill	1.7	1.9	4.1	-0.3	1.9	2.0	0.4	0.6	0.6	2.0	2.0	-0.2	1.4	2.0	-1.3	0.6
Hearing aid user	1.0	1.1	5.0	1.1	-0.7	0.9	0.5	0.2	0.9	-0.9	1.9	0.0	0.8	2.2	0.3	-0.5
Mother’s age at death	2.4	3.0	9.3	1.5	-3.1	-2.0	0.7	-1.4	-1.3	-2.2	-2.1	-0.9	1.8	0.2	2.4	-0.5
Financial situation satisfaction	0.7	0.9	3.6	0.1	0.6	1.1	0.1	0.6	0.8	0.7	-0.3	1.9	-0.9	0.8	-0.1	1.9
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.7	-0.1	0.5	1.6	-1.4	1.4	1.9	-0.3	1.3	0.1	0.4	-0.8	-1.1	-1.8
Commuting to job workplace: Public transport	0.4	0.5	3.0	-1.0	1.0	0.1	-0.2	-0.1	0.2	0.0	1.7	-0.1	-0.7	0.4	0.5	-0.8
Eye problems/disorders: Glaucoma	0.3	0.4	1.2	-0.4	-0.7	-1.1	-0.3	0.1	-0.3	-0.6	0.2	-0.2	-0.7	-1.0	0.1	-1.1
Medication: Blood pressure	1.6	3.1	9.4	-3.1	-1.1	1.1	-2.8	1.8	1.9	-0.2	-1.4	2.0	0.1	-2.6	-0.7	-0.7
Pain type(s) experienced in last month: Hip pain	1.4	1.7	7.0	0.7	2.4	1.6	-0.8	0.8	0.7	2.6	1.4	0.8	-0.7	-0.5	-1.0	0.8
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.5	0.3	-0.2	-0.8	0.8	-1.3	-1.6	0.1	-0.1	-0.6	-1.1	0.2	1.0	-0.1
High cholesterol (Self-reported)	1.3	2.3	7.0	-0.5	0.4	2.6	-2.3	1.8	1.9	1.4	-1.2	1.8	-0.8	-1.4	-0.6	0.7
Medication: Bendroflumethiazide	2.7	4.1	9.1	-3.0	1.4	2.3	-2.7	2.8	3.0	0.9	0.4	1.9	1.0	-1.6	-2.0	-0.6
Medication: Paracetamol	1.9	2.9	6.5	0.3	2.2	2.2	-1.2	2.3	2.1	2.5	0.7	1.1	-1.8	-1.3	-0.9	1.8
Medication: Lisinopril	0.5	0.7	2.3	-0.9	0.2	0.6	-1.5	0.6	0.5	-0.0	-0.3	-0.6	0.2	-1.4	-0.4	-1.3
Medication: Atorvastatin	1.8	2.2	6.5	-2.1	1.9	2.5	-0.4	1.5	1.6	1.8	1.1	1.3	0.5	1.1	-1.2	0.5
Illnesses of father: High blood pressure	0.3	0.4	0.9	-0.2	-1.0	-0.3	-0.6	0.6	0.8	-0.8	0.4	0.5	-0.6	-0.8	-0.2	-0.7
Alcohol drinker status: Never	0.7	0.8	2.9	-1.7	-0.8	0.7	-1.1	1.0	1.0	-0.1	0.6	0.2	1.2	-0.8	-0.5	-1.1
Ever smoked	1.7	2.9	15.4	-0.1	1.6	0.1	1.7	0.9	-0.3	1.3	-1.5	2.3	-1.9	1.1	1.5	3.9
Basal metabolic rate	0.2	1.3	3.8	-0.2	-1.9	-0.7	1.2	-1.0	-0.9	-1.6	0.4	-0.7	1.4	1.3	1.6	0.1
Leg fat percentage (left)	0.8	2.9	12.2	-2.8	-0.9	-0.0	-2.0	0.0	-0.2	-0.5	-0.9	-0.3	-2.1	-3.5	-0.9	-2.6
Arm fat-free mass (left)	0.3	1.3	4.5	-0.6	-2.1	-0.7	1.1	-1.1	-0.8	-1.7	0.2	-0.6	1.4	1.2	1.5	0.0
Number of operations (self-reported)	0.3	0.4	1.4	-0.8	-0.3	-0.1	-0.8	0.4	0.0	0.2	-0.6	0.9	-1.2	-1.1	0.6	0.2
Average weekly beer plus cider intake	0.9	1.3	5.3	2.3	-0.5	-0.8	1.9	-0.6	-0.8	-0.6	0.5	-0.1	0.1	1.9	0.8	1.1
Irritability	1.7	2.9	6.5	-0.3	1.4	2.5	-0.8	2.3	2.3	1.6	-2.1	2.4	0.4	-0.4	0.4	2.3
Risk taking	1.6	2.4	5.0	0.7	-1.6	-1.9	2.2	-2.0	-2.1	-1.2	-0.7	0.3	-0.2	1.6	1.9	1.6
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.8	-1.0	0.6	0.9	-1.7	0.4	0.7	0.4	-0.9	-0.6	1.0	-1.0	-0.9	-1.1
Fractured/broken bones in last 5 years	0.6	0.8	2.4	-1.5	-1.6	-0.1	0.3	-0.1	0.2	-0.6	1.3	1.1	0.8	0.8	0.7	-0.5
Age started oral contraceptive pill	0.6	0.7	2.1	-1.4	-1.4	-1.1	-0.4	-0.7	-0.6	-0.7	-0.1	-0.2	0.8	-0.4	0.6	-1.4
Diastolic blood pressure, automated reading	1.8	5.6	22.9	-1.9	-1.6	1.3	-3.1	1.9	2.5	-2.1	1.6	-0.1	1.4	-2.8	-2.4	-4.8
Ever depressed for a whole week	0.3	0.3	1.5	-1.2	0.1	0.9	-0.3	0.1	0.2	0.1	-0.8	0.8	-0.5	-0.1	0.4	0.1
Unable to work because of sickness or disability	0.7	1.0	7.1	-0.1	-0.2	0.9	1.3	-0.0	0.5	-0.0	0.7	0.3	-0.3	2.7	0.7	1.1
Commuting to job workplace: Cycle	0.4	0.5	2.0	-1.4	1.0	-0.2	-0.7	0.3	0.6	0.2	0.8	-0.9	0.2	0.3	-0.8	-0.7
Myopia	0.9	1.3	5.2	-0.0	-0.4	0.7	-1.5	1.5	1.3	0.2	-1.1	1.4	-0.8	-2.3	0.1	1.0
Vascular/heart problems diagnosed by doctor	2.0	5.5	11.2	3.3	1.1	-2.5	3.3	-3.2	-3.1	0.0	0.3	-2.7	-1.0	3.1	1.6	0.8
Cholesterol lowering medication	1.3	1.9	8.9	-2.7	-1.0	0.9	-1.0	0.8	1.5	-0.1	-0.8	3.0	0.9	-0.3	-0.1	0.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.8	-0.6	1.0	1.3	0.1	-0.0	0.0	1.3	-0.7	0.4	0.5	0.1	0.2	1.3
Pain experienced in last month	2.4	3.9	10.1	1.3	-3.1	-2.2	1.7	-2.1	-1.9	-3.2	-1.1	-0.2	2.7	1.1	1.9	-0.2
Supplements: Calcium	1.2	1.4	4.5	0.4	-0.9	-0.1	1.2	-0.6	-0.8	-0.4	-1.6	1.0	1.6	0.6	2.1	1.7
Basal cell carcinoma (self-reported)	1.7	2.0	5.6	1.0	-1.7	-2.4	1.9	-1.8	-1.9	-1.2	1.0	-0.9	1.2	0.8	1.0	0.3
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.1	-0.8	0.4	1.2	-0.9	1.8	1.0	1.6	-1.0	1.2	-1.5	-1.1	-0.0	1.7
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.6	-0.1	-0.7	-0.7	-0.5	-0.7	-0.9	-0.9	-0.4	-0.4	-1.9	-0.4	-0.8	-1.7
Heart disease (siblings)	1.3	1.5	5.3	-1.1	0.7	0.3	-0.6	1.0	0.6	1.8	-0.6	1.9	-1.7	-1.1	0.0	2.3
Alcohol drinker status: Previous	0.4	0.5	3.3	0.9	-0.5	-0.6	0.1	0.0	0.1	-0.3	0.8	-1.8	-0.8	0.2	0.0	-0.6
Pack years of smoking	0.5	0.7	1.6	0.7	0.4	-0.1	1.1	-1.0	-1.3	0.9	0.0	-0.7	-0.6	1.2	0.0	1.1
Impedance of whole body	0.4	2.0	8.9	-0.3	3.0	1.3	0.6	-0.3	-0.0	1.7	1.3	-1.6	0.6	1.8	-1.9	-0.2
Leg fat mass (left)	0.4	1.6	4.8	-2.2	-1.6	-0.4	-1.1	-0.2	-0.4	-1.1	-0.3	-0.4	-1.5	-2.1	-0.0	-1.9
Arm predicted mass (left)	0.4	1.8	4.6	-0.4	-2.1	-0.8	1.5	-1.4	-1.0	-2.0	0.2	-0.8	1.8	1.6	1.7	0.1