[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) :

chr20:46,838,455-48,603,940

Best TWAS P=3.66e-14 · Best GWAS P=3.15e-14 conditioned to 0.0179

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ARFGEF2 0.09 0.05 lasso 8 0.10 9.2e-13 7.6 -7.6 3.7e-14 -0.83 0.00 1.00 TRUE
2 GTEx Cells Transformed fibroblasts STAU1 0.08 0.03 lasso 6 0.02 2.3e-02 5.2 6.1 1.3e-09 0.85 0.03 0.91 FALSE
3 GTEx Colon Sigmoid CSE1L 0.18 0.12 lasso 11 0.09 4.4e-04 5.8 -5.9 4.7e-09 -0.81 0.14 0.80 FALSE
4 GTEx Colon Transverse ARFGEF2 0.11 0.07 enet 12 0.09 2.9e-05 -1.9 -5.3 1.3e-07 -0.80 0.04 0.95 FALSE
5 GTEx Esophagus Mucosa ZFAS1 0.15 0.01 enet 16 0.01 8.9e-02 6.5 5.6 2.8e-08 0.69 0.07 0.76 FALSE
6 GTEx Lung CSE1L 0.10 0.09 lasso 5 0.08 6.6e-07 5.3 -5.3 1.0e-07 -0.74 0.45 0.54 FALSE
7 GTEx Skin Sun Exposed Lower leg CSE1L 0.08 0.03 lasso 2 0.03 9.5e-04 5.8 -5.4 6.7e-08 -0.82 0.34 0.38 FALSE
8 GTEx Skin Sun Exposed Lower leg ZFAS1 0.07 0.03 enet 14 0.05 5.8e-05 6.5 5.2 1.6e-07 0.78 0.18 0.76 FALSE
9 GTEx Testis ARFGEF2 0.20 0.20 lasso 7 0.24 5.4e-11 5.3 -6.7 2.2e-11 -0.93 0.02 0.98 FALSE
10 METSIM Adipose ARFGEF2 0.04 0.03 lasso 12 0.02 9.8e-05 7.5 -7.1 1.5e-12 -0.97 0.02 0.98 FALSE
11 NTR Blood NCRNA00275 0.07 0.06 lasso 4 0.08 9.7e-25 -2.6 -5.3 9.6e-08 -0.52 1.00 0.00 FALSE
12 NTR Blood SNORD12B 0.03 0.05 lasso 8 0.05 1.9e-14 6.5 -7.0 3.6e-12 -0.95 0.11 0.89 FALSE
13 The Cancer Genome Atlas Breast Invasive Carcinoma STAU1 0.01 0.01 blup 54 0.01 6.1e-03 -4.3 -5.5 4.1e-08 -0.45 0.03 0.13 FALSE
14 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CSE1L 0.03 0.05 lasso 1 0.03 9.3e-05 5.2 -5.2 1.7e-07 -0.76 0.30 0.61 FALSE
15 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CSE1L 0.05 0.07 blup 50 0.07 3.2e-08 5.7 -5.4 6.5e-08 -0.81 0.39 0.61 FALSE
16 The Cancer Genome Atlas Brain Lower Grade Glioma ARFGEF2 0.05 0.04 lasso 5 0.05 3.2e-06 7.6 -7.0 2.0e-12 -0.95 0.00 1.00 FALSE
17 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma C20orf199 0.05 0.06 lasso 4 0.06 1.0e-04 6.6 6.6 5.7e-11 0.91 0.00 0.96 FALSE
18 The Cancer Genome Atlas Thyroid Carcinoma ARFGEF2 0.06 0.01 blup 79 0.03 4.2e-04 -3.8 -5.4 6.2e-08 -0.43 0.75 0.05 FALSE
19 The Cancer Genome Atlas Thyroid Carcinoma DDX27 0.08 0.05 lasso 3 0.05 1.9e-05 6.5 5.4 7.3e-08 0.85 0.06 0.90 FALSE