TWAS hub - SEPN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.356	0.0850	1.6e-06	0.228	NA	0.205	NA	0.257	2.3e-07	NA	1.0e-06	NA	3.3e-08
2	GTEx	Cells Transformed fibroblasts	0.097	0.0360	6.3e-05	0.068	NA	0.056	NA	0.059	7.7e-06	NA	4.9e-05	NA	3.1e-05
3	GTEx	Muscle Skeletal	0.145	0.0334	6.0e-14	0.168	NA	0.171	NA	0.173	3.3e-16	NA	1.7e-16	NA	1.1e-16
4	GTEx	Thyroid	0.097	0.0420	4.1e-04	0.033	NA	0.035	NA	0.038	1.4e-03	NA	1.0e-03	NA	7.0e-04
5	ROSMAP	Brain Pre-frontal Cortex	0.113	0.0277	1.1e-16	0.170	0.146	0.146	0.159	0.167	2.5e-21	2.5e-18	2.8e-18	6.6e-20	7.2e-21
6	TCGA	Prostate Adenocarcinoma	0.134	0.0738	1.2e-04	0.016	0.035	0.045	NA	0.025	6.8e-03	1.3e-04	1.7e-05	NA	1.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Asthma (self-reported)	5.4	10.8	13.2	3.4	3.0	3.5	3.3	3.6	2.8
Asthma	4.8	9.4	12.2	3.0	2.5	3.4	3.3	3.5	2.6
Hair/balding pattern: Pattern 2	4.4	5.5	8.3	2.3	0.9	2.9	2.7	2.9	1.8
Falls in the last year	4.3	5.8	6.7	-2.5	-2.2	-2.1	-2.3	-2.6	-2.6
Neck or shoulder pain in last month	4.3	6.1	9.6	-3.1	-2.9	-2.2	-2.0	-2.2	-2.2
Ever had prostate specific antigen (PSA) test	4.3	4.9	8.6	-2.4	0.8	-2.6	-2.9	-2.6	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	3.8	12.2	30.1	-3.2	1.8	-3.6	-5.5	-3.9	-1.2
HbA1C	3.7	4.1	5.2	-2.0	-2.2	-2.2	-1.3	-2.3	-2.0
Waist Hip Ratio (WHR)	3.7	16.5	28.5	-5.3	-5.0	-4.3	-2.0	-3.9	-2.6
Forced vital capacity (FVC)	3.6	13.9	31.9	-3.8	2.5	-4.0	-5.7	-4.0	-0.2
Forced expiratory volume in 1-second (FEV1)	3.6	12.2	27.6	-3.6	2.1	-3.7	-5.3	-3.8	-0.5
Forced vital capacity (FVC), Best measure	3.5	12.8	34.3	-2.9	2.2	-3.7	-5.9	-3.8	-0.8
Blood Red Count	2.9	28.0	42.9	-6.1	-6.5	-5.1	-4.1	-4.8	-4.7
Comparative height size at age 10	2.9	15.7	31.8	-3.9	2.6	-4.6	-5.6	-4.4	-0.5
Mother’s age at death	2.8	3.5	8.6	-1.8	1.3	-1.7	-2.9	-2.1	-0.3
Maternal smoking around birth	2.7	3.9	9.5	1.2	-0.1	2.1	3.1	2.1	1.9
Pain experienced in last month	2.7	4.5	7.4	2.7	1.6	2.1	2.2	2.0	1.9
Medication: Ventolin 100micrograms inhaler	2.6	3.3	4.0	1.7	2.0	1.9	1.9	1.9	1.4
Supplements: Zinc	2.5	2.7	5.3	1.4	0.8	2.3	1.5	2.2	1.3
Allergy	2.5	5.9	7.5	-1.8	-2.3	-2.7	-2.7	-2.7	-2.1
Trunk fat percentage	2.4	9.5	21.2	-2.9	-4.6	-2.6	-2.0	-2.5	-3.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.6	7.7	1.5	2.8	1.5	1.2	1.5	2.4
Supplements: Vitamin C	2.4	2.9	11.4	0.9	3.4	0.9	-0.5	0.6	1.9
Had menopause	2.3	2.9	4.7	1.7	-0.5	2.1	2.2	2.0	0.8
Ever taken oral contraceptive pill	2.3	2.6	4.5	-1.6	-1.4	-2.1	-1.2	-2.1	-0.9
Eye problems/disorders: Diabetes related eye disease	2.2	2.4	8.4	0.5	-2.9	1.1	1.7	1.0	-1.0
Heart disease (mother)	2.2	2.7	6.6	-1.4	-2.0	-1.2	-0.7	-1.3	-2.6
Commuting to job workplace: Cycle	2.2	2.7	3.8	1.9	1.8	1.6	1.1	1.7	1.6
Hand grip strength (right)	2.1	5.7	12.2	-2.5	-0.1	-2.8	-3.5	-2.6	-0.9
Knee pain experienced in last month	2.1	3.2	4.6	-2.1	-1.3	-2.0	-1.8	-1.9	-1.5
Height	2.0	38.4	88.7	-5.6	3.3	-6.7	-9.4	-7.1	-2.1
Body fat percentage	2.0	8.0	20.5	-2.6	-4.5	-2.3	-1.6	-2.2	-2.9
Number of children fathered	2.0	2.3	3.2	-0.9	-1.7	-1.4	-1.8	-1.4	-1.8
Lung FVC	1.9	9.6	19.5	-2.7	2.0	-3.1	-4.4	-3.4	-2.3
Osteoarthritis (self-reported)	1.9	2.5	4.2	-1.5	-0.6	-2.0	-1.4	-1.6	-1.9
Coronary Artery Disease (CAD)	1.8	2.2	6.9	-1.9	-2.6	-1.0	-0.6	-1.2	0.2
Vitamin and mineral supplements	1.8	2.5	11.0	-0.9	-3.3	-0.1	0.8	0.2	-1.5
Fed-up feelings	1.8	3.3	7.7	0.6	-1.7	2.0	2.8	2.2	-0.1
Serious illness, injury or assault to yourself	1.8	2.2	4.2	1.1	2.0	1.1	1.0	1.3	1.9
Happiness	1.8	2.2	4.2	1.0	0.9	2.0	1.5	2.0	0.9
Osteoporosis (self-reported)	1.8	2.2	6.2	0.8	1.2	1.3	1.4	1.1	2.5
Unable to work because of sickness or disability	1.8	2.3	5.2	-2.3	-1.6	-1.7	-0.5	-1.6	0.8
Shortness of breath walking on level ground	1.7	2.1	3.5	1.0	1.9	1.5	0.9	1.4	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.7	10.5	-1.2	1.8	-1.7	-3.2	-1.9	-0.5
Blood Eosinophil Count	1.6	12.4	22.9	3.6	-0.7	4.1	4.8	4.0	2.1
Respiratory disease	1.6	3.5	4.2	2.0	2.0	1.9	2.0	1.7	1.6
Supplements: Glucosamine	1.6	2.1	4.7	-0.6	2.2	-1.4	-1.8	-1.4	0.2
Trunk fat mass	1.6	6.9	8.4	-2.6	-2.9	-2.6	-2.6	-2.6	-2.5
Standing height	1.6	15.5	37.5	-3.3	3.1	-4.1	-6.1	-4.1	-0.7
Cholesterol lowering medication	1.6	2.4	4.9	1.2	-0.6	1.5	2.2	1.7	1.6
Basal cell carcinoma (self-reported)	1.6	1.9	3.8	1.8	0.2	1.4	1.9	1.4	0.4
Multivitamins +/- minerals	1.5	1.9	8.2	1.1	2.9	-0.3	-0.8	-0.2	1.2
Alcohol intake versus 10 years previously	1.5	2.2	3.1	-1.0	-1.8	-1.5	-1.6	-1.3	-1.6
Worrier / anxious feelings	1.5	2.9	11.6	0.0	3.4	0.2	0.4	0.4	2.3
Chronic bronchitis/emphysema (mother)	1.5	1.8	6.3	-1.2	-2.5	-0.1	1.3	0.3	1.1
Leg fat percentage (right)	1.5	5.5	20.4	-1.5	-4.5	-1.2	-0.6	-1.0	-2.7
Hayfever, allergic rhinitis or eczema	1.4	3.1	4.7	1.3	1.5	2.0	2.2	2.1	1.4
Mouth/teeth dental problems	1.4	2.1	6.6	1.8	2.6	1.1	0.8	1.0	0.1
Hair/balding pattern: Pattern 3	1.4	2.0	4.0	-1.1	0.0	-1.8	-2.0	-1.9	-0.4
Mouth/teeth dental problems: Dentures	1.4	2.3	4.0	-0.9	-2.0	-1.8	-1.4	-1.8	-0.9
Birth weight of first child	1.4	2.6	4.1	-2.0	0.4	-1.9	-1.9	-1.9	-0.7
Gout (self-reported)	1.4	2.0	3.7	-1.7	-1.9	-1.3	-0.4	-1.1	-1.5
Commuting to job workplace: Walk	1.4	1.5	3.4	-1.1	0.6	-1.3	-1.8	-1.3	-0.7
Supplements: Fish oil (including cod liver oil)	1.4	1.8	9.5	0.9	3.1	0.0	-0.6	-0.3	0.1
Rheumatoid Arthritis	1.3	1.8	2.8	1.6	1.3	1.2	1.3	0.9	1.7
Systolic Blood Pressure	1.3	6.4	14.1	2.0	3.8	2.1	1.9	1.8	3.0
Hand grip strength (left)	1.3	3.4	8.5	-2.3	0.2	-2.0	-2.9	-1.7	-0.3
Diabetes (mother)	1.3	1.6	5.9	-1.6	-2.4	-0.8	0.0	-0.7	-0.3
Waist circumference	1.3	4.9	7.0	-2.4	-2.6	-2.4	-1.5	-2.2	-2.0
Hearing difficulty/problems with background noise	1.3	2.1	3.9	1.2	-0.7	1.7	2.0	2.0	0.0
Pain all over the body in last month	1.3	1.4	2.3	-1.4	0.3	-1.5	-1.5	-1.3	0.2
Impedance of arm (right)	1.3	6.1	20.4	-2.6	-4.5	-1.6	-0.4	-1.3	-2.2
Impedance of arm (left)	1.3	6.2	14.1	-3.0	-3.8	-2.2	-1.0	-1.9	-2.1
Health satisfaction	1.3	1.6	4.2	-2.0	-0.7	-0.9	-1.6	-0.9	-0.9
Mouth/teeth dental problems: Loose teeth	1.3	1.6	5.2	-1.6	-2.3	-0.7	-0.9	-0.4	-0.2
Emphysema/chronic bronchitis	1.3	1.4	2.4	0.2	0.8	1.5	1.6	1.5	1.0
Whole body fat mass	1.3	5.3	7.4	-2.3	-2.7	-2.3	-2.1	-2.3	-2.1
Arm fat percentage (left)	1.3	5.0	14.4	-1.8	-3.8	-1.8	-0.8	-1.6	-2.4
Mineral and other dietary supplements	1.3	1.8	7.7	-0.2	-2.8	0.5	1.3	0.6	-0.8
Pain type(s) experienced in last month: Hip pain	1.3	1.6	4.5	-2.1	-0.5	-1.1	-1.4	-1.2	-0.4
Fasting Glucose	1.2	1.4	4.8	-0.8	-1.6	-0.1	-0.7	-0.2	-2.2
Allergy or Eczema	1.2	3.1	4.2	1.4	2.0	1.9	1.5	1.8	1.9
Relative age of first facial hair	1.2	2.4	4.0	2.0	0.9	1.7	1.7	1.7	0.9
Relative age voice broke	1.2	1.8	2.7	1.6	-0.2	1.6	1.6	1.7	0.6
Arm fat percentage (right)	1.2	4.8	15.5	-1.7	-3.9	-1.5	-0.5	-1.4	-2.4
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	3.7	-0.4	-1.8	1.4	1.9	1.5	0.8
Number of live births	1.2	1.7	3.0	-1.7	-1.6	-1.1	-0.2	-1.2	-1.4
Exposure to tobacco smoke at home	1.2	1.4	5.0	0.7	-2.2	0.9	1.1	0.8	-0.3
Hair/balding pattern: Pattern 4	1.2	2.9	4.8	-2.1	-0.5	-2.2	-0.9	-2.2	-1.5
Loud music exposure frequency	1.2	1.3	4.1	-1.4	-2.0	-0.8	-0.5	-0.7	-0.7
High blood pressure (siblings)	1.2	1.8	3.1	-1.2	1.1	-1.1	-1.8	-1.0	1.6
Alcohol intake frequency.	1.2	2.7	4.7	-2.2	-0.2	-2.0	-1.8	-2.1	-0.0
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.4	-1.0	-1.9	-1.1	-0.5	-1.0	-1.5
Age started oral contraceptive pill	1.2	1.5	3.2	1.8	1.6	1.2	0.2	0.8	1.2
Schizophrenia vs Biploar Disorder	1.1	1.5	4.8	0.2	2.2	0.7	-0.0	0.9	1.6
Hearing difficulty/problems: Yes	1.1	1.7	7.8	-0.1	-2.8	0.0	0.6	0.2	-1.4
Sitting height	1.1	7.8	21.1	-0.8	4.6	-1.7	-4.3	-2.0	-0.0
Trunk predicted mass	1.1	6.0	21.1	0.1	4.6	-1.4	-3.2	-1.5	0.9
Long-standing illness, disability or infirmity	1.1	1.7	2.8	1.3	-0.7	1.5	1.7	1.6	0.7
Eye problems/disorders: Cataract	1.1	1.2	2.6	-1.6	-0.7	-1.3	-0.7	-1.1	-1.0
Average weekly champagne plus white wine intake	1.1	1.5	2.6	-1.5	1.1	-1.4	-1.0	-1.6	-0.1
Leg fat percentage (left)	1.1	4.1	17.8	-1.2	-4.2	-0.8	-0.1	-0.7	-2.1
Impedance of whole body	1.1	5.5	17.4	-2.6	-4.2	-1.6	-0.5	-1.4	-2.0
Mean Putamen Volume	1.0	1.2	5.1	-0.1	0.4	-0.6	-0.9	-0.8	-2.3
Lupus	1.0	1.5	2.1	1.4	-1.0	1.3	1.1	1.5	-0.9
Triglycerides	1.0	1.7	3.1	1.1	-1.4	1.5	1.8	1.2	0.1
Medication: Metformin	1.0	1.4	5.8	-0.1	-2.4	0.2	1.4	0.6	-0.1
Impedance of leg (right)	1.0	5.0	18.1	-1.8	-4.3	-1.1	-0.2	-0.8	-2.6
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	3.2	0.5	-1.4	0.7	-0.3	0.5	-1.8
Trunk fat-free mass	1.0	6.0	20.2	0.0	4.5	-1.4	-3.3	-1.5	0.8
Tense / ‘highly strung’	1.0	1.6	3.0	-0.0	0.5	1.7	1.7	1.2	1.4
Arm fat-free mass (right)	1.0	4.9	14.5	-0.2	3.8	-1.4	-3.2	-1.6	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.1	-1.3	-0.1	-0.8	-1.3	-1.0	-1.5
Illnesses of siblings: Diabetes	1.0	1.3	2.4	-1.5	-1.6	-0.9	-0.5	-1.2	-0.7
Eye problems/disorders: Glaucoma	1.0	1.2	1.8	1.3	-0.6	1.2	1.2	1.4	-0.6
Age at First Birth	0.9	1.3	1.9	1.4	1.0	1.0	0.5	1.2	1.4
Angina	0.9	1.1	2.5	1.6	0.2	0.9	1.0	1.3	0.9
Alcohol usually taken with meals	0.9	1.5	7.5	0.7	2.7	0.1	-0.8	-0.2	0.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.0	-1.3	0.2	-1.4	-1.1	-1.2	0.3
Medication: Ramipril	0.9	1.2	2.4	1.1	0.6	0.8	1.5	0.9	1.4
Father’s age at death	0.9	1.2	2.6	-1.1	1.4	-0.9	-1.6	-0.8	-0.0
Number of full brothers	0.9	1.1	2.0	0.6	-1.1	1.2	1.4	1.2	0.6
Leg fat mass (right)	0.9	3.3	8.5	-1.4	-2.9	-1.4	-1.3	-1.3	-2.1
Arm predicted mass (right)	0.9	4.7	14.8	-0.1	3.9	-1.3	-3.0	-1.5	0.6
Pulse rate, automated reading	0.9	3.0	13.8	-0.8	-3.7	0.1	1.4	0.4	-1.1
Whole body fat-free mass	0.9	5.1	14.7	-0.3	3.8	-1.5	-3.3	-1.6	0.6
Whole body water mass	0.9	5.1	14.8	-0.3	3.9	-1.5	-3.3	-1.6	0.5
Hearing aid user	0.9	1.0	1.8	1.3	-0.3	0.9	1.3	1.2	0.3
Average weekly beer plus cider intake	0.9	1.3	6.6	-0.1	-2.6	0.3	0.9	0.4	-0.1
Fractured/broken bones in last 5 years	0.9	1.1	2.4	0.8	-1.6	0.9	1.0	1.0	-0.9
Heart disease (siblings)	0.9	1.1	1.9	0.6	1.0	1.3	0.4	1.2	1.4
Blood Platelet Count	0.8	9.8	18.1	-1.3	-2.5	-3.4	-3.1	-3.4	-4.3
Cardiovascular Disease	0.8	2.5	8.2	1.2	1.4	1.1	1.2	1.1	2.9
Systolic blood pressure, automated reading	0.8	2.3	6.9	1.8	2.6	1.3	0.9	0.8	0.9
Diabetes (father)	0.8	0.9	2.9	0.7	-1.7	0.4	1.3	0.5	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.5	0.3	-0.5	1.6	1.5	1.3	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	3.1	-1.5	-0.1	-1.7	-1.5	-1.8	-1.0
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.4	1.6	0.4	1.3	1.1	1.1	0.1
Peak expiratory flow (PEF)	0.8	2.0	5.1	-1.2	1.5	-1.1	-2.2	-1.2	0.4
Birth weight	0.8	1.7	4.2	-1.2	0.5	-1.4	-2.0	-1.3	-0.9
Medication: Omeprazole	0.8	1.0	3.8	-1.3	-1.9	-0.3	0.4	-0.1	-0.5
Suffer from ‘nerves’	0.8	1.3	2.2	-0.4	-1.2	1.2	1.5	1.0	1.3
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.6	0.8	-0.3	1.3	1.2	1.3	-0.1
Arm fat mass (left)	0.8	3.3	4.7	-1.6	-2.2	-1.9	-1.6	-1.8	-1.8
Financial situation satisfaction	0.8	1.0	1.9	1.0	-0.3	1.1	1.1	1.4	0.8
Illnesses of father: High blood pressure	0.8	1.0	2.1	1.3	-0.1	1.0	1.4	0.7	0.8
Basal metabolic rate	0.8	4.2	10.2	-0.6	3.0	-1.7	-3.2	-1.7	0.2
Arm fat-free mass (left)	0.8	3.9	11.4	0.1	3.4	-1.2	-2.9	-1.4	0.4
Irritability	0.8	1.3	5.1	-1.4	-2.2	0.0	0.7	-0.0	-0.6
Neuroticism (2016)	0.7	1.0	3.0	-1.7	-0.4	-1.0	-0.7	-1.0	-0.7
Ulcerative Colitis	0.7	1.1	1.9	0.9	-0.7	1.1	1.4	0.9	1.0
Leg fat-free mass (left)	0.7	4.0	10.2	-1.0	2.4	-1.8	-3.2	-1.9	-0.1
Qualifications: CSEs or equivalent	0.7	1.0	1.2	1.1	0.9	1.0	0.9	0.9	1.1
Impedance of leg (left)	0.7	3.6	15.3	-1.6	-3.9	-0.6	0.3	-0.5	-1.8
Leg predicted mass (left)	0.7	3.8	9.9	-0.8	2.5	-1.7	-3.1	-1.8	-0.1
Diabetes (self-reported)	0.7	1.0	3.4	0.2	-1.8	0.2	1.1	0.8	0.8
Illnesses of siblings	0.7	1.0	1.8	1.1	-1.1	0.3	1.1	0.4	-1.4
Pulse rate	0.7	1.2	4.5	-0.6	-2.1	0.7	1.1	0.7	0.6
Glaucoma (self-reported)	0.7	0.8	1.6	0.9	-0.3	1.1	1.1	1.3	-0.2
Pulse wave peak to peak time	0.7	0.9	1.9	-0.3	0.8	-1.0	-1.4	-1.1	-0.6
Medication: Seretide 50 evohaler	0.7	0.8	2.2	0.6	1.5	0.7	0.8	0.8	0.7
Chest pain or discomfort	0.7	1.0	2.2	-0.7	-1.5	0.7	1.3	0.5	-1.0
Family relationship satisfaction	0.7	0.9	2.0	0.4	-0.0	1.4	1.0	1.4	0.4
Leg fat-free mass (right)	0.7	3.7	8.6	-0.7	2.9	-1.4	-2.9	-1.6	0.5
Mood swings	0.7	1.3	2.7	0.5	-0.5	1.3	1.6	1.4	0.9
Ever had bowel cancer screening	0.7	0.9	2.4	-0.3	1.5	0.8	0.0	0.6	1.3
Diabetes diagnosed by doctor	0.7	1.1	4.9	-0.4	-2.2	0.0	1.2	0.5	0.3
Medication for cholesterol	0.7	1.0	4.4	-0.4	-1.1	-0.2	-0.5	-0.2	-2.1
Leg predicted mass (right)	0.7	3.6	8.8	-0.6	3.0	-1.4	-2.8	-1.5	0.5
Number of self-reported non-cancer illnesses	0.7	1.2	3.9	0.5	0.4	0.9	1.0	1.0	2.0
Miserableness	0.7	1.3	2.3	-0.6	0.3	1.1	1.4	1.2	1.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	3.2	-1.3	-1.8	-0.2	0.1	-0.1	-0.7
Leg fat mass (left)	0.7	2.6	7.4	-1.3	-2.7	-1.2	-1.1	-1.2	-1.7
Depression (Nagel 2018)	0.6	0.8	1.8	-1.3	-1.3	-0.6	-0.5	-0.8	0.5
Irritable Bowel Disease (IBD)	0.6	1.5	2.3	1.4	0.5	1.5	0.7	1.2	1.5
Heel T-Score	0.6	5.1	8.5	-1.3	0.7	-2.8	-2.0	-2.9	-2.9
Type 2 Diabetes (T2D) (2018)	0.6	1.1	5.2	-0.3	-2.3	-0.1	1.1	0.5	0.0
Average weekly spirits intake	0.6	0.7	1.1	-0.8	0.6	-0.9	-1.0	-1.0	-0.7
Ever had hysterectomy (womb removed)	0.6	0.7	2.7	-1.0	-1.6	-0.1	0.4	-0.1	0.1
Current tobacco smoking	0.6	0.9	2.9	-1.1	-1.7	-0.6	0.1	-0.6	-0.9
Taking other prescription medications	0.6	0.9	2.6	-0.0	0.1	1.0	0.8	1.0	1.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.3	-0.7	-1.5	-0.6	-0.4	-0.7	-0.6
Past tobacco smoking	0.6	1.1	5.2	0.8	2.3	0.0	-0.5	-0.4	0.0
Fluid intelligence score	0.6	1.3	2.3	-1.4	0.3	-1.5	-1.0	-1.4	0.7
Neuroticism score	0.6	1.2	2.7	-0.9	0.1	1.0	1.4	0.9	1.6
Weight	0.6	2.9	7.0	-1.5	-0.1	-1.9	-2.6	-1.9	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.1	-0.3	0.1	-0.8	-1.5	-1.0	-1.0
Arm fat mass (right)	0.6	2.6	4.4	-1.4	-2.1	-1.5	-1.3	-1.5	-1.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.3	-0.9	0.1	0.3	0.6	0.3	1.8
Worry too long after embarrassment	0.6	0.9	2.7	-0.4	1.6	0.1	-0.5	-0.1	1.6
Age at first live birth	0.6	1.1	3.1	1.7	1.8	0.6	-0.4	0.4	-0.0
Angina (self-reported)	0.6	0.8	1.9	1.4	0.1	0.6	0.8	1.0	0.9
Illnesses of father: Heart disease	0.6	0.8	1.0	1.0	-0.0	1.0	1.0	0.9	-0.8
Smoking status: Previous	0.6	0.9	4.0	-1.0	-2.0	-0.4	-0.1	0.1	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.6	-0.8	-1.3	-0.8	-0.9	-0.8	-1.1
High cholesterol (Self-reported)	0.6	1.0	3.9	-0.3	-2.0	0.2	1.4	0.2	0.3
Arm predicted mass (left)	0.6	3.1	9.5	0.0	3.1	-1.0	-2.6	-1.1	0.5
Bipolar Disorder (2018)	0.5	0.8	2.0	0.8	-1.2	0.4	1.4	0.2	-0.8
Schizophrenia (2018)	0.5	1.0	2.6	-1.6	-1.4	-0.8	-0.4	-0.5	-0.3
Alzheimer’s Disease (in mother)	0.5	0.5	1.3	1.1	0.3	0.8	0.8	0.7	-0.1
Alzheimer’s Disease (in father)	0.5	0.6	1.3	-0.6	0.2	-0.5	-1.0	-0.7	-1.1
Ulcerative Colitis (UC)	0.5	1.0	2.3	1.5	-0.0	0.9	1.0	0.8	1.0
Prostate Cancer	0.5	0.7	1.3	1.0	0.4	0.9	0.9	1.2	0.5
Sensitivity / hurt feelings	0.5	0.9	2.3	-0.8	-0.6	0.8	1.5	0.7	0.9
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.9	-1.0	-1.7	0.2	0.8	0.2	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.2	0.1	-0.6	1.1	0.9	1.1	0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.1	0.9	0.2	0.6	0.2	0.5	-1.5
Number of incorrect matches in round	0.5	0.8	1.5	0.2	1.2	-0.8	-1.1	-0.8	0.8
Noisy workplace	0.5	0.6	2.5	-1.0	-1.6	-0.1	-0.2	-0.3	-0.2
Qualifications: A levels/AS levels or equivalent	0.5	1.0	4.8	1.0	2.2	0.3	-0.1	0.2	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	0.9	0.1	-0.9	0.8	0.9	0.8	-0.4
Depression (self-reported)	0.5	0.6	1.1	-0.7	-0.4	1.0	1.0	0.8	0.5
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.9	-1.0	-1.7	-0.0	-0.0	0.1	-0.2
Exposure to tobacco smoke outside home	0.5	0.6	2.4	0.1	-1.6	0.7	0.5	0.5	0.4
Medication: Allopurinol	0.5	0.6	2.5	-0.4	-1.6	0.3	0.9	0.3	-0.1
Overall health rating	0.5	1.1	1.8	0.3	-0.6	1.3	1.2	1.2	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.9	0.7	0.9	0.8	-0.1	0.6	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.4	-0.8	-1.5	0.2	0.4	0.3	-0.8
Back pain experienced in last month	0.5	0.7	2.4	-1.2	-1.5	0.1	0.2	0.5	-0.2
Medication: Blood pressure	0.5	1.0	2.2	-0.3	1.5	-0.8	-0.5	-0.8	1.5
Medication: Atorvastatin	0.5	0.7	2.0	-0.4	-1.4	0.2	0.8	-0.0	-1.1
Supplements: Calcium	0.5	0.5	1.8	-1.4	-0.2	0.1	0.0	0.0	1.1
Alcohol drinker status: Previous	0.5	0.5	1.5	-0.3	-1.2	-0.8	0.0	-1.0	0.1
Bipolar Disorder or Schizophrenia	0.4	0.9	3.6	-0.7	-1.9	-0.4	0.6	-0.3	-0.8
Worry (Nagel 2018)	0.4	0.8	1.9	-1.2	1.1	0.2	0.5	0.1	1.4
Crohns Disease (2017)	0.4	0.8	1.5	0.6	0.6	1.2	-0.1	1.0	1.2
HDL Cholesterol	0.4	0.7	1.2	-1.1	1.0	-0.8	-0.7	-0.7	0.4
Smoking Status	0.4	0.9	2.6	-0.0	-0.8	1.0	1.6	1.1	0.3
Neuroticism	0.4	0.9	2.2	-1.5	0.9	0.2	0.3	0.1	1.5
Chronotype (morning person)	0.4	0.9	4.4	0.7	2.1	0.3	0.5	0.3	0.0
Townsend deprivation index at recruitment	0.4	0.5	1.2	0.8	-0.9	0.5	1.1	0.5	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.6	-0.9	-0.2	-1.2	-1.2	-1.3	-0.6
High blood pressure	0.4	1.0	3.1	0.1	1.6	-0.3	-0.2	-0.4	1.8
Chronic bronchitis/emphysema (father)	0.4	0.5	1.2	0.4	-0.0	0.7	0.7	0.6	1.1
High blood pressure (mother)	0.4	0.6	2.4	0.1	0.3	0.6	0.5	0.6	1.6
Nervous feelings	0.4	0.8	2.5	-0.3	1.2	0.4	0.6	0.2	1.6
Qualifications: None of the above	0.4	0.8	2.4	-0.8	-1.5	-0.5	0.1	-0.3	-1.1
Time employed in main current job	0.4	0.4	0.7	-0.4	-0.5	-0.7	-0.4	-0.8	-0.8
Illnesses of mother	0.4	0.5	1.1	0.1	0.8	-0.7	-1.1	-0.7	-0.6
Pulse wave Arterial Stiffness index	0.4	0.4	0.9	0.2	-0.6	0.7	0.9	0.8	0.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.9	0.8	1.4	0.6	0.7	0.3	0.4
Comparative body size at age 10	0.4	1.0	1.9	-0.9	-0.4	-1.3	-1.4	-1.1	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	-0.3	-0.4	1.0	0.9	1.0	0.4
Qualifications: College or University degree	0.4	1.3	6.0	0.6	2.5	-0.5	-0.9	-0.3	0.1
Medication for pain relief, constipation, heartburn	0.4	0.8	3.1	0.8	1.8	0.3	0.6	0.3	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.4	-1.2	-0.6	0.1	-0.0	-0.3	-0.9
Number of full sisters	0.4	0.5	1.7	0.5	-0.5	0.7	1.3	0.7	0.3
Hypertension (Self-reported)	0.4	1.0	2.9	0.1	1.7	-0.3	-0.2	-0.4	1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.6	-1.1	1.1	-0.6	-1.3	-0.6	0.3
Loneliness, isolation	0.4	0.5	0.9	0.5	0.2	0.9	0.9	0.8	0.7
Friendships satisfaction	0.4	0.5	1.5	0.0	0.2	1.2	0.7	1.1	-0.0
Qualifications: nursing, teaching	0.4	0.6	1.1	-0.0	0.9	-0.8	-1.1	-0.6	0.8
Medication: Lisinopril	0.4	0.6	0.9	0.9	0.4	0.9	0.9	0.9	0.1
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.6	-1.3	-0.6	-1.1	-0.7	-1.1	-0.4
Alzheimer’s Disease (including proxy)	0.3	0.5	1.3	1.1	0.4	0.7	0.9	0.6	-0.1
Major Depression (MDD)	0.3	0.3	1.5	0.5	1.2	0.2	0.0	0.3	0.3
Reaction Time	0.3	0.6	1.7	-0.1	1.1	0.5	0.3	0.6	1.3
Verbal and Numeric Reasoning (VNR)	0.3	0.6	0.9	-0.8	0.9	-0.9	-0.9	-0.7	0.3
Ovarian Cancer	0.3	0.3	0.5	0.5	0.3	0.7	0.7	0.6	0.6
Bipolar Disorder (2011)	0.3	0.3	1.1	-0.6	-1.0	-0.1	0.4	-0.0	-0.3
LDL Cholesterol	0.3	0.5	1.0	0.2	-0.8	0.7	1.0	0.8	0.2
Primary Biliary Cirrhosis	0.3	0.5	0.8	-0.0	-0.9	0.7	0.9	0.8	-0.3
BMI	0.3	2.0	2.7	-1.4	-1.6	-1.4	-1.5	-1.3	-1.2
Hypothyroidism (self reported)	0.3	0.6	2.8	-0.0	-1.7	-0.2	-0.1	-0.2	-0.8
Number of treatments/medications taken	0.3	0.5	2.3	-0.6	0.3	0.0	-0.2	0.2	1.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.2	-1.1	0.7	-0.2	-0.7	-0.6	0.1
Medication: Co-codamol	0.3	0.3	1.0	-0.8	0.3	-0.3	-1.0	-0.5	-0.2
Stomach or abdominal pain in last month	0.3	0.4	1.4	-1.2	-0.2	0.1	-0.3	0.0	-1.0
Hip circumference	0.3	1.4	3.1	-0.5	-0.2	-1.3	-1.8	-1.4	-1.1
Medication: Cholesterol lowering	0.3	0.5	2.4	-0.2	-1.6	0.2	0.5	0.5	0.1
Prospective memory result	0.3	0.4	0.9	0.9	0.9	0.6	0.5	0.5	-0.1
Migraine (self-reported)	0.3	0.3	0.9	0.3	-0.4	0.2	0.5	0.7	1.0
Medication: Gliclazide	0.3	0.3	1.4	-0.1	-1.2	-0.2	0.5	0.1	-0.3
Smoking status: Current	0.3	0.5	1.7	-0.9	-1.3	-0.2	0.4	-0.3	-0.6
Guilty feelings	0.3	0.5	1.8	-1.3	-0.8	-0.3	-0.5	-0.4	-0.2
Wears glasses or contact lenses	0.3	0.4	0.9	-0.0	0.2	0.9	0.4	0.7	0.9
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.6	-0.3	1.3	0.4	-0.3	0.2	-0.3
Alcohol drinker status: Never	0.3	0.3	0.7	-0.5	-0.4	-0.5	-0.8	-0.8	-0.4
Ever smoked	0.3	0.5	2.0	-0.8	-1.4	-0.5	-0.2	-0.2	0.2
Ever depressed for a whole week	0.3	0.4	0.7	-0.5	-0.3	-0.7	-0.8	-0.6	-0.5
Myopia	0.3	0.5	1.3	-0.1	0.8	0.7	0.1	0.7	1.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	3.3	-0.1	-1.1	0.3	0.1	0.2	-1.8
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.5	0.7	-0.4	0.6	0.7	0.7	0.2
Depressed Affect (Nagel 2018)	0.2	0.5	1.1	-0.0	-0.4	0.7	1.0	0.9	0.5
Neuroticism (Nagel 2018)	0.2	0.4	1.9	-1.4	0.4	-0.1	0.2	-0.0	0.6
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	0.4	0.7	-0.1	-0.6	-0.4	-0.3
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.9	0.5	-1.0	0.2	0.7	-0.1	0.0
Medication for hormone replacement therapy	0.2	0.2	1.1	0.1	-1.1	-0.3	0.0	-0.3	0.2
Severe depression (siblings)	0.2	0.2	0.6	0.3	0.8	-0.1	0.0	-0.1	0.6
Pack years adult smoking proportion	0.2	0.2	0.9	0.2	-0.5	0.3	0.4	0.1	-1.0
Average weekly fortified wine intake	0.2	0.3	0.9	-0.4	0.1	-0.4	-0.9	-0.6	-0.1
Age when periods started (menarche)	0.2	0.4	1.1	0.3	1.0	-0.1	-0.9	-0.4	-0.7
Medication: Levothyroxine sodium	0.2	0.4	1.6	-0.5	-1.3	-0.3	-0.1	-0.2	-0.7
Had other major operations	0.2	0.2	0.6	0.1	-0.2	0.8	0.5	0.6	0.4
Financial difficulties in last 2 years	0.2	0.3	0.7	-0.8	-0.7	-0.5	-0.2	-0.3	-0.3
Medication: Simvastatin	0.2	0.3	0.8	0.2	-0.4	0.3	0.7	0.6	0.9
Medication: Lansoprazole	0.2	0.2	0.7	-0.8	-0.2	-0.1	-0.6	-0.2	0.1
Breastfed as a baby	0.2	0.2	0.9	-1.0	0.1	-0.1	-0.4	-0.4	-0.2
Medication: Paracetamol	0.2	0.4	1.1	-1.0	-0.7	-0.0	-0.2	0.1	0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	2.1	0.1	-1.5	0.4	0.3	0.4	-0.5
Wheeze or whistling in the chest in last year	0.2	0.3	1.8	0.1	0.4	0.0	0.2	0.3	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.1	0.2	1.1	-0.0	-0.5	-0.2	0.0
Medication: Ibuprofen	0.2	0.3	1.2	-0.0	-0.0	-0.1	-1.1	-0.4	-0.5
Leg pain on walking	0.2	0.3	0.9	-0.9	-0.4	-0.3	-0.7	-0.0	0.1
Illnesses of father: None of the above (group 1)	0.2	0.3	0.8	-0.3	0.9	-0.4	-0.8	0.1	0.3
Medication: Bendroflumethiazide	0.2	0.3	1.5	0.1	0.3	0.1	0.0	0.0	1.2
Number of operations (self-reported)	0.2	0.3	0.6	-0.5	0.2	-0.4	-0.6	-0.8	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	0.5	0.2	0.7	0.3	0.8	0.5
Pack years of smoking	0.2	0.4	1.1	0.6	-0.5	0.4	0.4	0.2	-1.0
Breast Cancer	0.1	0.2	0.7	0.2	-0.6	-0.3	0.0	-0.1	-0.8
Crohns Disease (2012)	0.1	0.2	0.5	-0.1	0.5	0.0	-0.6	0.0	0.7
Schizophrenia (2014)	0.1	0.2	1.2	-1.1	-0.3	-0.4	0.1	-0.2	-0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.3	-0.4	-0.6	-0.4	0.2	-0.5	0.1
Hair Pigment	0.1	2.8	9.4	0.9	-3.1	0.8	1.7	1.1	-1.4
Tanning	0.1	0.7	1.3	-1.1	0.1	-1.0	-0.9	-1.0	0.3
Medication: Atenolol	0.1	0.1	0.4	-0.5	0.0	0.1	0.2	-0.1	0.7
Body mass index (BMI)	0.1	0.6	2.6	-0.1	-1.6	-0.2	-0.0	-0.2	-0.8
Heart attack	0.1	0.1	0.2	0.5	-0.5	0.3	0.4	0.4	0.1
Lung cancer (father)	0.1	0.2	0.5	-0.0	0.2	-0.5	-0.2	-0.3	0.7
Pulse wave reflection index	0.1	0.1	0.3	0.1	0.1	0.3	0.6	0.2	-0.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	0.7	0.7	0.3	-0.2	0.3	0.3
Blood clot in the leg (DVT)	0.1	0.2	0.5	0.3	0.0	0.5	-0.1	0.7	0.3
Headache pain in last month	0.1	0.2	0.5	-0.0	-0.6	-0.6	-0.3	-0.3	-0.7
Medication: Amlodipine	0.1	0.1	0.3	-0.3	0.2	0.4	-0.2	0.1	0.6
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.2	0.2	-0.0	-0.6	-0.3	0.4
Medication: Blood pressure	0.1	0.2	0.3	-0.4	-0.2	-0.5	-0.5	-0.3	-0.4
Mean time to correctly identify matches	0.1	0.2	0.5	-0.1	0.7	0.1	-0.2	0.2	0.7
Age at last live birth	0.1	0.2	0.6	-0.3	-0.2	-0.4	-0.8	-0.4	-0.5
Medication: Aspirin	0.1	0.2	0.5	0.1	-0.6	0.2	0.2	0.2	-0.7
Average weekly red wine intake	0.1	0.2	0.4	0.4	0.7	0.4	-0.1	0.4	0.4
Medication: Aspirin	0.1	0.1	0.4	-0.3	-0.5	0.0	0.1	0.1	-0.6
Medication: Paracetamol	0.1	0.2	0.5	-0.7	-0.4	0.1	-0.1	0.3	0.7
Risk taking	0.1	0.2	0.5	-0.7	-0.0	-0.0	0.1	-0.0	0.7
Diastolic blood pressure, automated reading	0.1	0.4	1.7	1.3	0.3	0.5	0.4	0.2	0.0
Blood White Count	0.0	0.2	0.5	0.0	-0.1	0.4	0.0	0.5	-0.7
Lung FEV1/FVC ratio	0.0	0.2	0.7	0.1	0.8	0.6	-0.5	0.3	0.3
Length of working week for main job	0.0	0.0	0.1	-0.3	-0.0	-0.2	-0.1	-0.2	-0.3
Had major operations	0.0	0.0	0.1	0.1	0.1	-0.2	-0.1	-0.2	0.4
Handedness (chirality/laterality): Left-handed	0.0	0.1	0.1	-0.1	-0.3	0.3	0.2	0.3	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.2	-0.3	-0.1	-0.1	0.0	0.0	-0.4
Breast cancer (self-reported)	0.0	0.0	0.1	0.2	0.1	-0.1	0.0	-0.0	-0.2
Commuting to job workplace: Public transport	0.0	0.0	0.1	-0.1	-0.3	-0.1	-0.0	-0.1	-0.1

Hub : Genes

SEPN1

Models

Trait associations