[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) :

chr4:105,373,669-107,622,327

Best TWAS P=6.56e-23 · Best GWAS P=5.65e-26 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex INTS12 0.06 0.06 enet 5 0.05 2.9e-07 9.4 -9.4 8.2e-21 0.08 0.75 0.25 FALSE
2 GTEx Adipose Subcutaneous PPA2 0.15 0.02 enet 36 0.06 7.0e-06 5.4 -5.7 9.4e-09 0.35 0.26 0.14 FALSE
3 GTEx Adipose Subcutaneous GSTCD 0.08 0.07 lasso 8 0.07 2.9e-06 7.5 8.8 9.0e-19 -0.13 0.89 0.08 TRUE
4 GTEx Adipose Visceral Omentum PPA2 0.15 0.04 lasso 6 0.05 9.1e-04 5.6 -6.2 5.3e-10 0.37 0.12 0.19 FALSE
5 GTEx Adrenal Gland INTS12 0.23 0.02 enet 21 0.04 1.4e-02 2.7 -7.5 5.7e-14 0.06 0.18 0.07 TRUE
6 GTEx Artery Aorta PPA2 0.11 -0.01 enet 24 0.01 1.6e-01 -10.5 -9.4 8.1e-21 0.68 0.01 0.86 FALSE
7 GTEx Artery Aorta INTS12 0.13 0.14 lasso 3 0.14 6.5e-08 8.4 -8.6 9.7e-18 0.09 0.69 0.28 FALSE
8 GTEx Brain Cerebellum PPA2 0.22 0.01 lasso 4 0.03 3.7e-02 -7.0 -5.3 8.8e-08 0.56 0.08 0.16 FALSE
9 GTEx Brain Cortex PPA2 0.14 0.09 lasso 9 0.09 1.6e-03 -7.9 -8.0 1.1e-15 0.79 0.06 0.60 FALSE
10 GTEx Cells EBV-transformed lymphocytes GSTCD 0.16 0.07 lasso 17 0.03 4.3e-02 8.5 8.9 4.2e-19 -0.08 0.36 0.12 TRUE
11 GTEx Cells Transformed fibroblasts PPA2 0.11 0.03 lasso 3 0.01 6.5e-02 -4.6 -5.2 2.2e-07 0.59 0.28 0.38 TRUE
12 GTEx Cells Transformed fibroblasts INTS12 0.15 0.16 lasso 9 0.17 9.5e-13 8.5 -9.2 5.3e-20 0.08 0.84 0.16 FALSE
13 GTEx Esophagus Gastroesophageal Junction PPA2 0.29 0.15 lasso 5 0.14 8.8e-06 -10.5 -9.8 6.6e-23 0.89 0.00 0.99 TRUE
14 GTEx Esophagus Mucosa PPA2 0.18 0.06 enet 14 0.12 2.5e-08 7.4 -9.1 7.8e-20 0.75 0.02 0.98 FALSE
15 GTEx Esophagus Muscularis INTS12 0.12 0.10 lasso 15 0.10 1.3e-06 9.2 -8.9 6.7e-19 0.06 0.81 0.17 FALSE
16 GTEx Heart Atrial Appendage PPA2 0.15 0.05 lasso 7 0.06 7.4e-04 -7.7 -6.9 5.1e-12 0.65 0.19 0.50 FALSE
17 GTEx Lung PPA2 0.09 0.02 enet 16 0.03 1.4e-03 3.1 -6.4 1.8e-10 0.49 0.14 0.52 FALSE
18 GTEx Lung NPNT 0.07 0.02 enet 24 0.04 2.3e-04 9.2 -5.7 1.0e-08 0.00 0.04 0.92 FALSE
19 GTEx Muscle Skeletal PPA2 0.19 0.06 enet 28 0.11 8.7e-11 -7.3 -5.2 2.0e-07 0.60 0.69 0.30 FALSE
20 GTEx Nerve Tibial PPA2 0.13 0.07 enet 23 0.07 2.1e-05 -7.0 -6.9 5.2e-12 0.59 0.24 0.63 FALSE
21 GTEx Nerve Tibial GSTCD 0.09 0.03 enet 16 0.02 1.3e-02 8.0 9.2 5.7e-20 -0.13 0.56 0.05 FALSE
22 GTEx Ovary PPA2 0.18 0.10 lasso 3 0.14 2.2e-04 -7.0 -7.3 2.6e-13 0.69 0.02 0.90 FALSE
23 GTEx Pituitary GSTCD 0.28 0.14 lasso 5 0.09 2.8e-03 8.4 7.8 5.7e-15 -0.12 0.33 0.10 FALSE
24 GTEx Skin Sun Exposed Lower leg PPA2 0.09 0.07 lasso 3 0.04 4.3e-04 5.6 -5.4 5.9e-08 0.29 0.67 0.02 FALSE
25 GTEx Skin Sun Exposed Lower leg GSTCD 0.08 0.02 lasso 6 0.01 3.8e-02 7.8 9.1 9.0e-20 -0.14 0.68 0.15 FALSE
26 GTEx Skin Sun Exposed Lower leg TET2 0.09 0.01 enet 18 0.02 3.6e-03 -10.0 -6.4 1.3e-10 0.63 0.05 0.72 FALSE
27 GTEx Thyroid INTS12 0.07 0.05 lasso 7 0.03 1.2e-03 9.2 -9.2 2.3e-20 0.08 0.70 0.20 FALSE
28 ROSMAP Brain Pre-frontal Cortex PPA2 0.32 0.38 lasso 2 0.38 1.1e-51 5.6 -6.1 1.3e-09 0.38 1.00 0.00 FALSE
29 YFS Blood PPA2 0.22 0.05 lasso 19 0.12 9.7e-38 -3.5 5.2 2.3e-07 -0.48 1.00 0.00 FALSE
30 The Cancer Genome Atlas Bladder Urothelial Carcinoma INTS12 0.04 0.03 blup 51 0.04 3.9e-04 8.5 -8.8 1.9e-18 0.13 0.01 0.96 FALSE
31 The Cancer Genome Atlas Breast Invasive Carcinoma INTS12 0.04 0.03 blup 49 0.04 7.1e-08 8.4 -9.6 5.2e-22 0.09 0.01 0.99 FALSE
32 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma INTS12 0.12 0.06 blup 50 0.08 1.2e-04 9.2 -9.6 5.2e-22 0.10 0.01 0.98 FALSE
33 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma INTS12 0.03 0.02 blup 49 0.02 6.4e-03 9.2 -9.7 2.5e-22 0.11 0.01 0.87 TRUE
34 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma INTS12 0.08 0.10 lasso 2 0.10 2.9e-11 9.2 -9.2 2.8e-20 0.08 0.01 0.99 FALSE
35 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PPA2 0.11 0.03 blup 84 0.03 4.7e-04 -7.0 -5.4 7.3e-08 0.55 0.22 0.61 TRUE
36 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma INTS12 0.32 0.00 blup 49 0.06 1.8e-04 8.4 -9.4 8.2e-21 0.09 0.01 0.80 FALSE
37 The Cancer Genome Atlas Brain Lower Grade Glioma GSTCD 0.07 0.05 lasso 4 0.04 6.6e-05 9.4 9.7 4.6e-22 -0.09 0.01 0.99 FALSE
38 The Cancer Genome Atlas Lung Adenocarcinoma INTS12 0.08 0.10 enet 11 0.10 9.9e-12 9.2 -8.9 3.6e-19 0.10 0.01 0.99 TRUE
39 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma INTS12 0.03 0.01 blup 49 0.03 6.0e-03 5.4 -7.5 8.5e-14 0.16 0.02 0.64 FALSE
40 The Cancer Genome Atlas Pancreatic Adenocarcinoma INTS12 0.22 0.15 lasso 6 0.16 2.3e-07 8.5 -8.8 1.3e-18 0.06 0.02 0.96 FALSE
41 The Cancer Genome Atlas Prostate Adenocarcinoma INTS12 0.15 0.11 lasso 3 0.17 2.1e-17 4.8 -7.8 6.8e-15 0.15 0.05 0.95 FALSE
42 The Cancer Genome Atlas Stomach Adenocarcinoma GSTCD 0.04 0.06 lasso 1 0.05 9.1e-05 9.1 9.1 1.0e-19 -0.09 0.03 0.89 FALSE
43 The Cancer Genome Atlas Thyroid Carcinoma INTS12 0.11 0.09 blup 49 0.11 1.3e-10 9.2 -9.1 1.4e-19 0.13 0.01 0.99 FALSE
44 The Cancer Genome Atlas Thyroid Carcinoma PPA2 0.04 0.02 blup 84 0.04 6.1e-05 -7.3 -6.8 1.5e-11 0.72 0.14 0.66 FALSE