[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) : ← →

chr4:105,373,669-107,622,327

Best TWAS P=6.56e-23 · Best GWAS P=5.65e-26 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
13	GTEx	Esophagus Gastroesophageal Junction	PPA2	0.29	0.15	lasso	5	0.14	8.8e-06	-10.5	-9.8	6.6e-23	0.89	0.00	0.99	TRUE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	INTS12	0.03	0.02	blup	49	0.02	6.4e-03	9.2	-9.7	2.5e-22	0.11	0.01	0.87	TRUE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	INTS12	0.08	0.10	enet	11	0.10	9.9e-12	9.2	-8.9	3.6e-19	0.10	0.01	0.99	TRUE
10	GTEx	Cells EBV-transformed lymphocytes	GSTCD	0.16	0.07	lasso	17	0.03	4.3e-02	8.5	8.9	4.2e-19	-0.08	0.36	0.12	TRUE
3	GTEx	Adipose Subcutaneous	GSTCD	0.08	0.07	lasso	8	0.07	2.9e-06	7.5	8.8	9.0e-19	-0.13	0.89	0.08	TRUE
5	GTEx	Adrenal Gland	INTS12	0.23	0.02	enet	21	0.04	1.4e-02	2.7	-7.5	5.7e-14	0.06	0.18	0.07	TRUE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPA2	0.11	0.03	blup	84	0.03	4.7e-04	-7.0	-5.4	7.3e-08	0.55	0.22	0.61	TRUE
11	GTEx	Cells Transformed fibroblasts	PPA2	0.11	0.03	lasso	3	0.01	6.5e-02	-4.6	-5.2	2.2e-07	0.59	0.28	0.38	TRUE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	GSTCD	0.07	0.05	lasso	4	0.04	6.6e-05	9.4	9.7	4.6e-22	-0.09	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	INTS12	0.04	0.03	blup	49	0.04	7.1e-08	8.4	-9.6	5.2e-22	0.09	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	INTS12	0.12	0.06	blup	50	0.08	1.2e-04	9.2	-9.6	5.2e-22	0.10	0.01	0.98	FALSE
6	GTEx	Artery Aorta	PPA2	0.11	-0.01	enet	24	0.01	1.6e-01	-10.5	-9.4	8.1e-21	0.68	0.01	0.86	FALSE
1	CommonMind	Brain Pre-frontal Cortex	INTS12	0.06	0.06	enet	5	0.05	2.9e-07	9.4	-9.4	8.2e-21	0.08	0.75	0.25	FALSE
36	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INTS12	0.32	0.00	blup	49	0.06	1.8e-04	8.4	-9.4	8.2e-21	0.09	0.01	0.80	FALSE
27	GTEx	Thyroid	INTS12	0.07	0.05	lasso	7	0.03	1.2e-03	9.2	-9.2	2.3e-20	0.08	0.70	0.20	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	INTS12	0.08	0.10	lasso	2	0.10	2.9e-11	9.2	-9.2	2.8e-20	0.08	0.01	0.99	FALSE
12	GTEx	Cells Transformed fibroblasts	INTS12	0.15	0.16	lasso	9	0.17	9.5e-13	8.5	-9.2	5.3e-20	0.08	0.84	0.16	FALSE
21	GTEx	Nerve Tibial	GSTCD	0.09	0.03	enet	16	0.02	1.3e-02	8.0	9.2	5.7e-20	-0.13	0.56	0.05	FALSE
14	GTEx	Esophagus Mucosa	PPA2	0.18	0.06	enet	14	0.12	2.5e-08	7.4	-9.1	7.8e-20	0.75	0.02	0.98	FALSE
25	GTEx	Skin Sun Exposed Lower leg	GSTCD	0.08	0.02	lasso	6	0.01	3.8e-02	7.8	9.1	9.0e-20	-0.14	0.68	0.15	FALSE
42	The Cancer Genome Atlas	Stomach Adenocarcinoma	GSTCD	0.04	0.06	lasso	1	0.05	9.1e-05	9.1	9.1	1.0e-19	-0.09	0.03	0.89	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	INTS12	0.11	0.09	blup	49	0.11	1.3e-10	9.2	-9.1	1.4e-19	0.13	0.01	0.99	FALSE
15	GTEx	Esophagus Muscularis	INTS12	0.12	0.10	lasso	15	0.10	1.3e-06	9.2	-8.9	6.7e-19	0.06	0.81	0.17	FALSE
40	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	INTS12	0.22	0.15	lasso	6	0.16	2.3e-07	8.5	-8.8	1.3e-18	0.06	0.02	0.96	FALSE
30	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	INTS12	0.04	0.03	blup	51	0.04	3.9e-04	8.5	-8.8	1.9e-18	0.13	0.01	0.96	FALSE
7	GTEx	Artery Aorta	INTS12	0.13	0.14	lasso	3	0.14	6.5e-08	8.4	-8.6	9.7e-18	0.09	0.69	0.28	FALSE
9	GTEx	Brain Cortex	PPA2	0.14	0.09	lasso	9	0.09	1.6e-03	-7.9	-8.0	1.1e-15	0.79	0.06	0.60	FALSE
23	GTEx	Pituitary	GSTCD	0.28	0.14	lasso	5	0.09	2.8e-03	8.4	7.8	5.7e-15	-0.12	0.33	0.10	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	INTS12	0.15	0.11	lasso	3	0.17	2.1e-17	4.8	-7.8	6.8e-15	0.15	0.05	0.95	FALSE
39	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	INTS12	0.03	0.01	blup	49	0.03	6.0e-03	5.4	-7.5	8.5e-14	0.16	0.02	0.64	FALSE
22	GTEx	Ovary	PPA2	0.18	0.10	lasso	3	0.14	2.2e-04	-7.0	-7.3	2.6e-13	0.69	0.02	0.90	FALSE
16	GTEx	Heart Atrial Appendage	PPA2	0.15	0.05	lasso	7	0.06	7.4e-04	-7.7	-6.9	5.1e-12	0.65	0.19	0.50	FALSE
20	GTEx	Nerve Tibial	PPA2	0.13	0.07	enet	23	0.07	2.1e-05	-7.0	-6.9	5.2e-12	0.59	0.24	0.63	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	PPA2	0.04	0.02	blup	84	0.04	6.1e-05	-7.3	-6.8	1.5e-11	0.72	0.14	0.66	FALSE
26	GTEx	Skin Sun Exposed Lower leg	TET2	0.09	0.01	enet	18	0.02	3.6e-03	-10.0	-6.4	1.3e-10	0.63	0.05	0.72	FALSE
17	GTEx	Lung	PPA2	0.09	0.02	enet	16	0.03	1.4e-03	3.1	-6.4	1.8e-10	0.49	0.14	0.52	FALSE
4	GTEx	Adipose Visceral Omentum	PPA2	0.15	0.04	lasso	6	0.05	9.1e-04	5.6	-6.2	5.3e-10	0.37	0.12	0.19	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	PPA2	0.32	0.38	lasso	2	0.38	1.1e-51	5.6	-6.1	1.3e-09	0.38	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	PPA2	0.15	0.02	enet	36	0.06	7.0e-06	5.4	-5.7	9.4e-09	0.35	0.26	0.14	FALSE
18	GTEx	Lung	NPNT	0.07	0.02	enet	24	0.04	2.3e-04	9.2	-5.7	1.0e-08	0.00	0.04	0.92	FALSE
24	GTEx	Skin Sun Exposed Lower leg	PPA2	0.09	0.07	lasso	3	0.04	4.3e-04	5.6	-5.4	5.9e-08	0.29	0.67	0.02	FALSE
8	GTEx	Brain Cerebellum	PPA2	0.22	0.01	lasso	4	0.03	3.7e-02	-7.0	-5.3	8.8e-08	0.56	0.08	0.16	FALSE
19	GTEx	Muscle Skeletal	PPA2	0.19	0.06	enet	28	0.11	8.7e-11	-7.3	-5.2	2.0e-07	0.60	0.69	0.30	FALSE
29	YFS	Blood	PPA2	0.22	0.05	lasso	19	0.12	9.7e-38	-3.5	5.2	2.3e-07	-0.48	1.00	0.00	FALSE