[Hub]/) : Traits : Peak expiratory flow (PEF) : ← →

chr6:108,994,161-110,710,018

Best TWAS P=2.93e-10 · Best GWAS P=3.89e-09 conditioned to 0.591

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	AK9	0.12	0.09	lasso	7	0.10	2.1e-08	-5.6	5.3	8.8e-08	-0.91	0.06	0.93	FALSE
2	GTEx	Adipose Visceral Omentum	AK9	0.10	0.02	enet	27	0.04	2.7e-03	-5.6	5.2	2.6e-07	-0.90	0.05	0.93	FALSE
3	GTEx	Adipose Visceral Omentum	RP11-425D10.10	0.16	0.10	lasso	6	0.06	7.2e-04	-5.6	-5.5	3.5e-08	0.95	0.06	0.91	FALSE
4	GTEx	Artery Aorta	SMPD2	0.10	0.04	enet	11	0.03	1.5e-02	-5.1	-5.2	1.9e-07	0.91	0.05	0.93	FALSE
5	GTEx	Artery Tibial	MICAL1	0.08	0.02	lasso	3	0.01	6.5e-02	-5.8	-5.8	5.4e-09	0.99	0.02	0.96	FALSE
6	GTEx	Artery Tibial	AK9	0.13	0.12	enet	18	0.13	3.5e-10	-5.5	5.7	9.9e-09	-0.95	0.08	0.92	FALSE
7	GTEx	Artery Tibial	RP11-425D10.10	0.10	0.10	lasso	4	0.10	3.9e-08	-5.8	-6.2	7.5e-10	0.98	0.02	0.98	FALSE
8	GTEx	Brain Caudate basal ganglia	AK9	0.20	0.16	enet	16	0.17	1.1e-05	-5.4	5.3	9.8e-08	-0.91	0.08	0.89	FALSE
9	GTEx	Brain Cerebellar Hemisphere	AK9	0.24	0.17	lasso	3	0.11	1.0e-03	-5.6	5.5	4.2e-08	-0.97	0.07	0.80	FALSE
10	GTEx	Breast Mammary Tissue	SMPD2	0.14	0.09	lasso	5	0.05	2.2e-03	-5.1	-5.1	2.8e-07	0.87	0.12	0.75	FALSE
11	GTEx	Breast Mammary Tissue	RP11-425D10.10	0.12	0.12	lasso	1	0.08	5.1e-05	-5.6	-5.6	2.6e-08	0.97	0.04	0.96	FALSE
12	GTEx	Breast Mammary Tissue (Male)	AK9	0.10	0.03	lasso	3	-0.01	5.4e-01	-5.1	5.4	6.9e-08	-0.96	0.03	0.48	FALSE
13	GTEx	Breast Mammary Tissue (Female)	AK9	0.12	0.15	lasso	1	0.12	1.9e-04	-5.6	5.6	2.6e-08	-0.97	0.05	0.69	FALSE
14	GTEx	Breast Mammary Tissue (Female)	RP11-425D10.10	0.14	0.04	lasso	10	0.02	6.5e-02	-5.6	-5.5	3.6e-08	0.97	0.03	0.50	FALSE
15	GTEx	Cells Transformed fibroblasts	SMPD2	0.20	0.13	lasso	9	0.15	3.1e-11	-5.1	-5.2	1.8e-07	0.90	0.22	0.77	FALSE
16	GTEx	Colon Transverse	RP11-425D10.10	0.12	0.13	enet	21	0.14	2.2e-07	-5.8	-5.7	1.1e-08	0.97	0.03	0.97	FALSE
17	GTEx	Esophagus Mucosa	SMPD2	0.17	0.20	lasso	10	0.22	2.2e-14	-5.6	-5.7	1.4e-08	0.98	0.02	0.98	FALSE
18	GTEx	Esophagus Mucosa	AK9	0.11	0.06	lasso	13	0.04	6.0e-04	-5.4	5.2	1.7e-07	-0.91	0.03	0.96	FALSE
19	GTEx	Esophagus Mucosa	RP11-425D10.10	0.09	0.13	lasso	5	0.12	1.1e-08	-5.6	-5.6	2.4e-08	0.97	0.08	0.92	FALSE
20	GTEx	Esophagus Muscularis	CD164	0.04	0.02	enet	6	0.01	1.0e-01	-5.6	-5.7	1.3e-08	0.96	0.04	0.83	FALSE
21	GTEx	Heart Atrial Appendage	RP11-425D10.10	0.12	0.11	lasso	5	0.07	4.0e-04	-5.6	-5.4	5.4e-08	0.91	0.06	0.92	FALSE
22	GTEx	Ovary	RP11-425D10.10	0.15	0.10	lasso	5	0.02	9.0e-02	-5.6	-5.6	1.9e-08	0.98	0.04	0.85	FALSE
23	GTEx	Pancreas	SMPD2	0.09	0.07	lasso	3	0.08	2.1e-04	-5.1	-5.3	1.3e-07	0.84	0.14	0.65	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	SMPD2	0.27	0.15	lasso	10	0.17	1.6e-09	-5.6	-5.5	3.0e-08	0.94	0.07	0.93	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	RP11-425D10.10	0.20	0.27	lasso	5	0.27	5.5e-15	-5.5	-5.5	2.9e-08	0.98	0.07	0.93	FALSE
26	GTEx	Skin Sun Exposed Lower leg	SMPD2	0.19	0.19	lasso	12	0.24	1.6e-19	-5.4	-5.7	1.0e-08	0.97	0.09	0.91	FALSE
27	GTEx	Skin Sun Exposed Lower leg	RP11-425D10.10	0.19	0.23	enet	18	0.23	3.4e-19	-5.5	-5.6	1.7e-08	0.95	0.07	0.93	FALSE
28	GTEx	Small Intestine Terminal Ileum	RP11-425D10.10	0.16	0.07	lasso	9	0.06	1.5e-02	-5.6	-5.5	4.8e-08	0.93	0.04	0.63	FALSE
29	GTEx	Testis	ZBTB24	0.11	0.11	lasso	4	0.10	4.9e-05	-5.6	5.5	3.8e-08	-0.94	0.11	0.85	FALSE
30	GTEx	Testis	SMPD2	0.28	0.18	lasso	7	0.17	7.6e-08	-5.1	-5.2	2.2e-07	0.88	0.21	0.79	FALSE
31	GTEx	Thyroid	AK9	0.11	0.08	enet	22	0.13	1.9e-10	-5.8	5.1	3.1e-07	-0.92	0.02	0.98	FALSE
32	GTEx	Vagina	RP11-425D10.10	0.42	0.22	lasso	19	0.17	9.0e-05	-5.6	-5.7	1.0e-08	0.98	0.03	0.94	FALSE
33	GTEx	Whole Blood	RP11-425D10.10	0.04	0.03	enet	16	0.03	6.2e-04	-5.6	-5.6	2.6e-08	0.97	0.03	0.96	FALSE
34	METSIM	Adipose	AK9	0.05	0.03	lasso	6	0.02	1.0e-04	-5.1	5.5	4.7e-08	-0.94	0.02	0.98	FALSE
35	METSIM	Adipose	SMPD2	0.06	0.08	enet	14	0.08	2.0e-12	-5.1	-6.3	2.9e-10	0.90	0.22	0.78	TRUE
36	YFS	Blood	SMPD2	0.06	0.08	lasso	7	0.08	2.5e-24	-5.1	-5.1	2.8e-07	0.86	0.38	0.62	FALSE
37	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AKD1	0.08	0.06	blup	114	0.05	4.7e-05	-5.4	5.4	5.7e-08	-0.89	0.05	0.95	FALSE
38	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SMPD2	0.04	0.04	blup	43	0.05	3.9e-05	-5.8	-5.7	1.2e-08	0.97	0.01	0.98	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMPD2	0.04	0.07	lasso	4	0.07	8.8e-14	-5.1	-5.2	2.3e-07	0.86	0.27	0.73	FALSE
40	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SMPD2	0.07	0.08	blup	45	0.07	2.3e-04	-5.1	-5.6	2.9e-08	0.92	0.03	0.93	FALSE
41	The Cancer Genome Atlas	Colon Adenocarcinoma	SMPD2	0.17	0.14	lasso	4	0.14	2.3e-08	-5.1	-5.2	1.7e-07	0.80	0.23	0.77	FALSE
42	The Cancer Genome Atlas	Esophageal Carcinoma	SMPD2	0.12	0.09	blup	41	0.07	2.6e-03	-5.6	-5.7	1.0e-08	0.99	0.01	0.88	FALSE
43	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AKD1	0.07	0.06	blup	116	0.06	4.2e-07	-5.9	5.4	5.8e-08	-0.94	0.02	0.98	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SMPD2	0.05	0.07	lasso	4	0.06	9.6e-08	-5.1	-5.3	1.1e-07	0.84	0.18	0.82	FALSE
45	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AKD1	0.11	0.06	lasso	3	0.06	2.7e-04	-5.4	5.4	7.3e-08	-0.92	0.04	0.96	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	AKD1	0.12	0.11	lasso	6	0.12	9.8e-14	-5.4	5.4	7.1e-08	-0.92	0.08	0.92	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZBTB24	0.04	0.05	lasso	4	0.04	7.8e-06	-5.8	5.7	1.1e-08	-0.99	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PPIL6	0.07	0.03	blup	53	0.02	5.8e-02	-5.1	5.6	2.2e-08	-0.94	0.02	0.57	FALSE
49	The Cancer Genome Atlas	Lung Adenocarcinoma	AKD1	0.05	0.03	blup	122	0.04	1.3e-05	-5.3	5.6	1.7e-08	-0.94	0.02	0.98	FALSE
50	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AKD1	0.06	0.07	lasso	4	0.05	2.8e-06	-5.6	5.3	9.6e-08	-0.89	0.04	0.96	FALSE
51	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SMPD2	0.04	0.06	blup	45	0.06	8.9e-08	-5.1	-5.3	1.3e-07	0.90	0.07	0.93	FALSE
52	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SMPD2	0.10	0.04	lasso	2	0.07	1.2e-03	-5.1	-5.2	1.7e-07	0.73	0.03	0.51	FALSE
53	The Cancer Genome Atlas	Stomach Adenocarcinoma	SMPD2	0.07	0.07	blup	44	0.08	3.4e-06	-5.8	-5.7	1.4e-08	0.96	0.01	0.99	FALSE