TWAS hub - MICAL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1720	0.0410	1.1e-12	0.118	0.116	0.143	0.139	0.144	3.4e-14	5.3e-14	4.5e-17	1.5e-16	4.0e-17
2	GTEx	Artery Tibial	0.0793	0.0393	2.8e-03	0.024	NA	0.008	NA	0.009	5.1e-03	NA	7.5e-02	NA	6.5e-02
3	GTEx	Esophagus Muscularis	0.4520	0.0790	5.4e-08	0.182	NA	0.263	NA	0.230	3.3e-11	NA	3.7e-16	NA	4.2e-14
4	GTEx	Testis	0.2840	0.0910	4.2e-04	0.025	NA	0.020	NA	0.005	2.8e-02	NA	4.2e-02	NA	1.9e-01
5	METSIM	Adipose	0.0602	0.0221	2.4e-05	0.014	0.026	0.027	0.028	0.028	2.9e-03	8.4e-05	5.6e-05	3.8e-05	4.5e-05
6	NTR	Blood	0.0410	0.0154	2.7e-06	0.026	0.012	0.014	0.012	0.018	8.3e-09	7.5e-05	2.0e-05	8.9e-05	1.1e-06
7	ROSMAP	Brain Pre-frontal Cortex	0.2051	0.0430	0.0e+00	0.172	0.184	0.184	0.185	0.181	1.4e-21	4.0e-23	4.5e-23	2.9e-23	9.6e-23
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0499	0.0281	8.4e-03	0.004	-0.002	0.003	NA	0.000	1.0e-01	9.5e-01	1.4e-01	NA	3.4e-01
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0426	0.0224	5.4e-03	0.009	0.016	0.011	NA	0.011	3.3e-02	6.3e-03	1.6e-02	NA	1.7e-02
10	TCGA	Brain Lower Grade Glioma	0.0762	0.0301	2.4e-11	0.113	0.111	0.118	NA	0.120	8.9e-13	1.5e-12	2.9e-13	NA	1.8e-13
11	TCGA	Stomach Adenocarcinoma	0.0890	0.0460	3.2e-03	0.011	0.013	0.003	NA	0.002	4.8e-02	3.5e-02	1.7e-01	NA	2.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	7	8	9	10	11
Sitting height	6.3	44.5	153.8	5.4	-12.4	-5.7	-8.0	3.1	7.3	-0.8	-7.5	9.4	1.0
Body Mass Index (BMI) (2010)	5.5	7.5	13.4	3.7	-2.5	2.1	-0.5	3.5	3.6	3.3	1.3	3.6	2.7
Forced expiratory volume in 1-second (FEV1)	5.4	18.4	57.5	4.6	-7.6	-3.2	-5.0	2.8	4.8	0.2	-2.8	6.3	3.0
Forced expiratory volume in 1-second (FEV1), Best measure	4.8	15.3	48.2	4.4	-6.9	-2.2	-4.4	2.8	4.4	0.5	-2.6	5.9	2.8
Forced vital capacity (FVC)	4.7	18.2	55.1	4.2	-7.4	-4.0	-5.7	2.4	4.5	-0.6	-3.2	5.9	2.8
Leg fat-free mass (right)	4.7	24.9	80.1	5.2	-8.9	-3.2	-6.8	3.1	5.1	0.5	-3.8	7.1	3.4
Leg fat-free mass (left)	4.6	24.6	75.2	5.4	-8.7	-3.1	-6.5	3.4	5.3	0.8	-3.3	7.1	3.6
Breastfed as a baby	4.6	5.8	15.9	-2.3	-1.7	-3.3	-1.6	-2.5	-0.9	-3.2	-4.0	-0.2	-2.9
Whole body water mass	4.6	26.1	83.4	5.1	-9.1	-3.8	-7.0	2.8	5.2	0.2	-4.1	7.2	3.3
Leg predicted mass (right)	4.6	24.4	78.9	5.1	-8.9	-3.2	-6.7	3.0	5.0	0.5	-3.9	7.0	3.3
Leg predicted mass (left)	4.5	23.9	73.7	5.2	-8.6	-3.1	-6.5	3.2	5.1	0.7	-3.4	7.0	3.5
Peak expiratory flow (PEF)	4.5	10.3	34.0	3.5	-5.8	-1.7	-3.4	2.2	3.9	0.4	-2.1	5.1	1.6
Arm fat-free mass (right)	4.5	22.8	72.4	4.6	-8.5	-4.0	-6.8	2.5	4.6	0.2	-3.9	6.5	3.3
Arm predicted mass (right)	4.5	22.9	72.1	4.7	-8.5	-3.9	-6.8	2.6	4.7	0.2	-3.7	6.5	3.5
Whole body fat-free mass	4.5	25.8	83.4	5.0	-9.1	-3.7	-7.0	2.8	5.1	0.1	-4.1	7.2	3.3
Trunk fat-free mass	4.4	25.5	82.3	4.7	-9.1	-4.0	-7.0	2.5	5.1	-0.3	-4.3	7.1	2.9
Trunk predicted mass	4.4	25.0	81.4	4.7	-9.0	-3.9	-6.9	2.5	5.0	-0.2	-4.3	7.0	2.8
Basal metabolic rate	4.4	24.3	75.3	5.3	-8.7	-3.2	-6.5	3.2	5.2	0.6	-3.4	7.0	3.7
Height	4.1	78.6	231.0	8.8	-15.2	-7.2	-10.4	6.4	11.2	0.5	-6.3	12.7	5.2
Arm fat-free mass (left)	4.1	20.8	68.4	4.4	-8.3	-3.6	-6.2	2.5	4.5	-0.0	-3.7	6.3	3.1
Forced vital capacity (FVC), Best measure	4.0	14.5	44.4	4.0	-6.7	-3.3	-4.9	2.2	4.0	-0.3	-3.0	5.4	2.6
Arm predicted mass (left)	4.0	20.1	65.9	4.2	-8.1	-3.8	-6.2	2.5	4.3	-0.2	-3.7	6.2	3.0
Bipolar Disorder (2011)	3.8	3.6	9.1	-2.5	2.6	-0.7	1.2	-1.9	-2.9	-1.4	0.1	-3.0	-1.2
Birth weight	3.7	7.9	24.5	0.9	-4.6	-3.7	-4.9	0.3	2.0	-2.0	-3.6	2.6	0.3
Friendships satisfaction	3.6	4.4	9.4	-2.7	2.6	-1.3	3.1	-1.7	-1.8	-1.5	-0.9	-3.0	-2.4
Standing height	3.5	34.5	108.2	4.6	-10.4	-5.6	-8.7	2.5	6.2	-1.4	-5.4	8.0	2.1
Weight	3.4	16.9	45.0	5.2	-6.7	-1.4	-4.4	3.5	4.7	2.1	-1.5	5.7	4.3
Supplements: Glucosamine	3.3	4.3	7.6	-2.7	2.3	-1.8	-0.1	-2.4	-2.6	-2.3	-0.4	-2.7	-2.3
Age when periods started (menarche)	2.7	6.4	14.7	3.5	-3.8	0.6	-0.8	2.2	3.6	2.4	-1.1	3.8	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.6	3.2	5.9	-2.4	2.4	1.1	1.2	-1.8	-2.4	-0.8	0.0	-2.3	-2.4
Ever had bowel cancer screening	2.6	3.0	7.2	-2.4	2.0	1.0	1.9	-1.9	-2.4	-0.6	0.1	-2.7	-1.3
Blood Red Count	2.5	24.4	60.8	4.9	-1.5	4.1	-7.8	5.2	3.2	2.5	7.4	6.4	5.1
Hip circumference	2.5	10.8	22.8	4.8	-4.7	0.5	-2.1	3.4	4.0	2.9	-0.1	4.5	3.6
Alcohol drinker status: Previous	2.4	2.8	5.5	-2.0	-0.3	-1.3	-1.3	-2.4	-2.2	-2.1	-1.8	-1.0	-1.9
Chronotype (morning person)	2.3	5.3	13.8	3.1	-2.4	1.0	-1.7	2.3	3.4	2.0	1.0	3.7	1.8
Other serious medical condition/disability diagnosed by doctor	2.3	3.0	7.3	-2.3	2.0	-0.1	1.6	-1.7	-2.7	-1.3	-0.1	-2.7	-1.5
Medication for hormone replacement therapy	2.3	2.6	5.3	-2.3	1.9	-1.3	0.2	-1.9	-1.8	-1.7	-0.8	-1.7	-2.2
Arm fat mass (right)	2.3	9.4	21.3	4.5	-3.2	1.3	-1.0	3.5	3.2	3.6	1.3	3.4	4.6
Mouth/teeth dental problems: Bleeding gums	2.3	2.9	7.5	-1.8	1.5	0.2	0.7	-2.7	-2.3	-0.5	-1.1	-2.2	-2.7
Heart disease (mother)	2.3	2.8	5.9	-2.4	1.2	-1.4	-0.9	-1.8	-2.3	-2.1	-1.0	-2.4	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	4.9	11.4	3.2	-3.3	-0.7	-0.7	2.4	2.8	1.3	-0.4	3.4	2.1
Diabetes (mother)	2.2	2.9	5.6	2.4	-2.2	0.2	-1.5	1.9	2.2	1.3	-0.0	2.3	1.9
Trunk fat mass	2.2	9.3	19.8	4.4	-3.7	0.8	-1.5	3.3	3.4	3.4	0.8	3.5	4.5
Age at first live birth	2.2	3.9	9.9	-2.1	2.8	-0.4	3.1	-1.9	-1.8	-0.4	-0.3	-3.0	-2.0
Comparative height size at age 10	2.2	11.9	39.3	2.1	-5.9	-3.4	-6.3	1.2	3.0	-1.7	-3.1	4.1	1.2
Family relationship satisfaction	2.1	2.6	7.8	-2.0	2.8	-0.2	2.1	-1.1	-1.4	-0.7	0.6	-2.3	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	15.8	1.2	-3.3	-2.4	-4.0	0.5	1.6	-0.8	-2.3	2.2	0.3
Arm fat mass (left)	2.1	8.8	19.7	4.4	-3.2	1.5	-1.1	3.2	3.0	3.6	1.1	3.2	4.4
Type 2 Diabetes (T2D) (2012)	2.0	2.4	6.2	1.8	-0.1	0.3	0.6	2.5	2.2	1.3	2.0	1.3	2.0
Blood Eosinophil Count	2.0	15.5	37.2	-5.2	6.1	-0.3	3.6	-3.9	-4.9	-1.9	0.7	-5.7	-4.2
Severe depression (siblings)	1.9	2.1	4.9	-2.2	1.0	-0.5	0.8	-1.9	-1.8	-1.2	-1.0	-2.0	-1.7
Had other major operations	1.9	2.3	6.3	-1.9	2.3	0.9	0.4	-1.4	-2.4	-0.7	1.0	-2.5	-0.6
Shortness of breath walking on level ground	1.9	2.2	7.4	1.2	1.1	2.7	1.2	1.1	0.5	2.6	1.9	0.2	1.1
Whole body fat mass	1.9	8.0	18.1	4.1	-3.2	0.8	-1.2	3.2	3.1	3.2	0.8	3.1	4.3
Leg fat mass (right)	1.9	7.3	17.3	3.9	-3.0	0.7	-1.1	3.1	2.9	3.0	0.9	2.9	4.2
HbA1C	1.8	2.0	5.9	1.6	-0.1	0.3	-1.6	1.8	1.8	0.5	1.9	2.4	0.5
LDL Cholesterol	1.8	2.9	9.6	-1.9	3.1	0.3	1.4	-0.7	-2.3	-0.9	1.7	-2.5	-0.9
Respiratory disease	1.8	3.9	12.3	-1.8	3.5	1.8	1.4	-1.3	-2.8	-0.2	2.2	-2.8	-0.2
Supplements: Zinc	1.8	2.0	4.3	-1.8	1.0	-1.8	-0.7	-1.6	-1.4	-2.1	-0.5	-1.6	-1.4
Happiness	1.8	2.2	4.7	-2.0	2.2	-0.9	2.0	-0.8	-0.9	-1.2	0.3	-2.2	-1.6
Wheeze or whistling in the chest in last year	1.8	3.2	9.5	-1.2	3.1	1.8	2.5	-0.3	-1.8	0.6	2.2	-2.4	0.7
Alcohol intake frequency.	1.8	4.3	15.4	2.5	-3.9	0.2	-2.4	1.2	1.6	0.8	-1.2	3.1	2.0
Arm fat percentage (left)	1.8	7.2	18.6	3.4	-0.3	3.1	1.2	2.8	1.6	4.3	2.9	1.2	4.2
Guilty feelings	1.8	2.7	7.8	-2.0	2.8	-0.1	1.2	-1.5	-2.1	-1.1	1.1	-2.2	-1.7
Diastolic blood pressure, automated reading	1.8	5.6	13.6	3.2	-1.9	0.6	-2.3	2.5	2.2	1.9	2.4	2.8	3.7
Leg fat mass (left)	1.8	7.1	16.5	3.9	-3.1	0.7	-1.3	2.9	2.8	3.0	0.7	2.9	4.1
Hand grip strength (right)	1.7	4.7	14.7	2.1	-3.8	-1.1	-2.8	0.8	2.6	0.6	-2.5	3.0	0.4
Medication: Atenolol	1.7	2.1	4.4	1.9	-2.1	1.0	-1.4	1.0	2.1	1.5	-0.4	2.0	0.6
Arm fat percentage (right)	1.7	6.7	16.2	3.2	-0.1	3.1	1.5	2.7	1.5	4.0	3.0	1.0	4.0
Chest pain or discomfort	1.7	2.4	6.8	-1.5	2.2	1.4	1.7	-1.4	-2.2	0.2	0.6	-2.6	-0.2
Had major operations	1.7	2.0	5.3	1.7	-2.2	-0.5	-0.8	0.9	2.3	0.8	-1.2	2.3	-0.1
Back pain experienced in last month	1.7	2.5	5.8	-1.9	1.8	0.8	0.8	-1.9	-2.4	-0.7	-0.6	-2.0	-2.3
Pack years of smoking	1.7	2.5	9.4	1.8	-0.3	1.4	0.2	2.3	1.2	1.2	2.0	1.0	3.1
Ever used hormone-replacement therapy (HRT)	1.6	2.1	7.8	-1.3	-0.6	-2.8	-0.5	-0.7	-0.2	-2.4	-1.9	0.0	-1.7
Pack years adult smoking proportion	1.6	2.5	9.1	1.7	-0.4	1.3	-0.1	2.3	1.3	1.1	1.9	1.1	3.0
Impedance of leg (left)	1.6	7.6	24.4	-2.8	4.9	1.5	3.7	-1.5	-2.7	-0.2	2.5	-4.3	-1.2
Waist circumference	1.6	5.9	11.8	3.4	-3.1	0.4	-1.4	2.9	2.8	2.2	0.3	2.9	3.4
Past tobacco smoking	1.6	3.0	6.9	2.6	-1.7	-0.1	-0.7	2.2	2.1	1.4	0.4	2.1	2.6
Qualifications: nursing, teaching	1.6	2.5	8.2	-1.1	1.6	1.5	2.9	-1.7	-1.5	1.0	-0.4	-2.0	-1.7
Pain type(s) experienced in last month: Hip pain	1.6	2.1	5.3	-0.7	2.3	2.2	1.6	-0.1	-1.5	0.7	1.5	-2.1	0.3
Vascular/heart problems diagnosed by doctor	1.6	4.4	9.4	-2.5	1.4	-3.1	1.1	-1.7	-2.5	-2.9	-1.7	-1.8	-2.4
Major Depression (MDD)	1.5	1.8	5.6	-0.8	2.1	0.8	1.7	-0.5	-1.4	0.6	1.6	-2.4	0.9
Lung FVC	1.5	7.6	24.9	3.3	-5.0	-1.9	-2.6	2.3	2.5	0.2	-2.1	3.8	2.8
Sensitivity / hurt feelings	1.5	2.6	6.5	-2.0	2.5	-1.6	0.7	-0.9	-1.9	-1.7	0.1	-2.5	-1.2
Trunk fat percentage	1.5	5.9	16.2	3.4	-1.3	1.9	0.3	2.9	2.0	3.5	2.2	1.7	4.0
Alcohol intake versus 10 years previously	1.5	2.3	5.4	1.4	-2.3	-0.8	-2.3	1.2	2.1	0.3	-0.9	2.2	0.4
Number of children fathered	1.5	1.7	7.2	0.2	-2.1	-0.3	-0.2	-0.3	0.7	-0.1	-2.7	1.6	-2.0
Hypertension (Self-reported)	1.5	4.2	7.6	2.6	-2.2	2.0	-1.4	1.7	2.8	2.5	1.0	2.2	2.4
Age at First Birth	1.4	2.0	4.7	-1.9	2.2	-0.5	1.2	-1.3	-1.7	-1.2	0.3	-1.8	-1.5
Primary Biliary Cirrhosis	1.4	1.9	5.3	-1.9	1.9	0.6	0.4	-1.5	-2.3	-0.6	0.5	-2.0	-1.3
High blood pressure	1.4	3.9	6.9	2.5	-2.0	2.3	-1.5	1.5	2.6	2.5	1.0	2.0	2.1
Handedness (chirality/laterality): Left-handed	1.4	1.7	4.6	1.5	-1.9	-0.0	-2.1	1.0	1.4	-0.1	-0.5	2.1	0.7
Impedance of whole body	1.4	7.3	24.4	-2.1	4.9	2.6	3.8	-1.0	-2.2	0.6	3.0	-3.7	-1.2
Blood Platelet Count	1.3	14.7	42.1	-4.1	6.5	0.2	6.4	-2.3	-3.6	-1.1	1.5	-5.9	-2.2
Impedance of leg (right)	1.3	6.5	23.2	-2.4	4.8	1.4	3.6	-1.0	-2.2	-0.1	2.7	-3.7	-0.9
Townsend deprivation index at recruitment	1.3	1.9	3.9	1.3	-1.3	0.6	-1.9	1.7	1.5	0.0	0.8	2.0	1.8
Average weekly fortified wine intake	1.3	1.5	5.1	-1.3	2.2	-0.7	1.2	-0.3	-1.1	-0.7	1.1	-2.3	-0.3
Body mass index (BMI)	1.3	5.4	13.2	3.4	-2.4	1.2	-0.7	2.6	2.1	3.0	0.9	2.5	3.6
Number of incorrect matches in round	1.3	2.1	4.2	-1.9	0.2	-2.1	-0.4	-1.9	-1.3	-1.9	-1.6	-1.2	-1.5
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	10.4	-0.2	-0.0	-3.2	-1.9	0.3	-1.3	-1.7	-0.3	-0.2	0.5
Body fat percentage	1.3	5.1	14.8	2.9	-0.6	2.1	0.8	2.5	1.5	3.5	2.4	1.0	3.9
Age at last live birth	1.3	1.9	6.4	-1.1	2.5	1.0	2.1	-0.9	-1.0	0.4	1.0	-2.1	-0.8
Average weekly beer plus cider intake	1.3	1.9	3.9	2.0	-0.9	0.1	-0.5	1.9	1.8	1.4	1.0	1.6	1.8
Irritability	1.3	2.1	5.8	-1.8	2.3	-0.5	1.6	-0.8	-1.6	-1.2	0.8	-2.4	-0.8
Alzheimer’s Disease (including proxy)	1.2	1.8	5.3	-2.0	1.3	-0.2	-0.0	-1.5	-1.6	-1.1	-0.7	-1.4	-2.3
Blood White Count	1.2	9.0	22.9	-4.2	3.7	-0.8	2.4	-3.3	-3.8	-2.3	-0.8	-4.8	-2.6
BMI	1.2	7.2	17.7	3.7	-1.0	2.4	0.4	3.1	2.2	4.1	2.5	1.7	4.2
Systolic blood pressure, automated reading	1.2	3.4	8.0	2.4	-1.8	1.0	-1.8	1.7	1.8	1.3	1.9	2.1	2.8
Relative age voice broke	1.2	1.9	4.1	-2.0	1.0	-1.3	-0.7	-1.7	-1.4	-1.5	-1.0	-1.6	-1.8
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	4.6	-0.6	2.1	1.5	1.3	0.1	-0.5	0.4	1.6	-1.5	0.2
Alcohol usually taken with meals	1.2	1.9	6.0	-1.0	2.4	0.9	2.2	-1.2	-0.8	0.5	1.0	-1.8	-1.3
Mouth/teeth dental problems	1.2	1.9	5.5	1.6	-1.5	0.1	-0.7	1.7	2.3	0.8	0.2	2.3	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	3.1	1.6	-1.0	-0.1	-0.5	1.6	1.8	1.1	0.6	1.7	1.2
Illnesses of siblings: Diabetes	1.2	1.5	4.6	1.4	-2.2	-0.1	-1.4	1.1	1.5	0.7	-1.0	1.7	0.8
Mother’s age at death	1.2	1.5	3.7	-1.7	1.1	-1.2	-0.3	-1.2	-1.6	-1.6	-0.2	-1.9	-0.7
Medication: Bendroflumethiazide	1.2	1.9	4.6	1.6	-2.1	-0.8	-1.8	1.0	1.7	0.9	-0.6	1.6	1.3
Medication: Paracetamol	1.2	1.8	6.0	1.9	-1.2	-0.4	0.0	2.1	1.2	1.1	0.5	1.1	2.4
Supplements: Calcium	1.2	1.3	4.6	-1.4	0.1	-0.3	0.6	-1.7	-0.9	-0.9	-1.3	-1.0	-2.1
Crohns Disease (2017)	1.1	2.3	4.6	2.2	-0.7	1.0	-0.4	2.0	1.8	1.4	1.8	2.0	1.7
Rheumatoid Arthritis	1.1	1.5	6.8	0.9	-2.1	-0.2	-2.6	-0.1	-0.1	0.0	-1.4	1.3	0.7
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.2	1.3	-1.1	1.2	0.1	1.7	1.2	0.8	0.3	0.8	1.8
Pain all over the body in last month	1.1	1.1	3.4	-0.5	-1.2	-1.3	-1.8	-1.2	-1.0	-0.8	-1.6	-0.2	-0.2
Time employed in main current job	1.1	1.2	3.2	1.4	-1.1	0.9	-0.9	1.3	0.8	0.7	1.0	1.2	1.8
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	4.4	-1.7	0.3	-1.7	-0.9	-0.7	-1.0	-2.1	-1.2	-0.6	-1.1
Impedance of arm (left)	1.1	4.9	15.4	-1.1	3.9	2.9	3.3	-0.4	-1.3	1.2	2.6	-2.6	-0.8
Birth weight of first child	1.1	1.9	4.8	1.0	-1.9	-2.2	-2.0	1.1	1.5	-0.6	-1.3	1.3	0.6
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	8.2	-1.0	2.2	1.0	1.0	0.9	-0.7	-0.6	2.9	-1.9	1.6
Leg fat percentage (right)	1.1	3.8	11.4	2.3	-0.1	1.9	1.0	2.2	1.0	3.0	2.4	0.6	3.4
Number of full brothers	1.1	1.4	2.9	-1.3	-0.3	-1.1	-1.7	-1.3	-0.9	-1.6	-1.2	-0.3	-1.4
Mineral and other dietary supplements	1.1	1.5	3.8	1.7	-1.4	1.5	0.5	1.0	1.2	1.9	-0.5	1.3	1.2
Average weekly champagne plus white wine intake	1.1	1.5	5.5	-1.3	0.3	-0.2	1.4	-1.6	-1.0	-0.5	-1.4	-1.1	-2.4
Ever taken oral contraceptive pill	1.1	1.3	5.8	-0.2	2.4	0.5	1.2	0.8	-0.2	0.6	2.1	-1.0	0.3
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.5	1.4	-0.5	1.3	0.6	1.5	1.0	1.6	1.1	0.9	1.5
Hypothyroidism (self reported)	1.0	2.3	7.0	-1.6	2.5	0.4	0.8	0.5	-1.2	-1.4	2.6	-2.1	0.9
Relative age of first facial hair	1.0	2.1	3.8	-2.0	0.4	-1.6	-0.3	-1.9	-1.4	-1.8	-1.8	-1.4	-1.7
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	3.9	-1.9	1.5	-0.6	0.7	-1.5	-1.7	-1.2	0.1	-2.0	-0.9
Hearing difficulty/problems with background noise	1.0	1.6	5.2	-1.6	2.3	0.0	1.4	-1.1	-1.2	-0.5	1.0	-1.9	-0.9
Impedance of arm (right)	1.0	4.5	13.8	-1.1	3.7	2.7	3.4	-0.4	-1.2	0.8	2.5	-2.4	-0.9
Loud music exposure frequency	1.0	1.1	2.9	-0.9	-0.5	-1.7	-1.5	-1.3	-0.5	-1.4	-1.4	-0.2	-0.8
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.8	0.2	2.2	1.6	1.0	-0.1	-0.5	1.2	2.0	-0.7	0.1
Health satisfaction	1.0	1.2	3.3	-0.7	1.8	1.7	1.4	-0.3	-1.0	0.5	1.1	-1.5	-0.1
Smoking status: Previous	1.0	1.5	3.9	-1.4	1.6	0.7	1.1	-1.6	-1.3	-0.2	0.3	-1.4	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	3.8	0.6	1.1	1.8	0.7	1.1	0.5	0.9	1.9	0.4	0.6
Number of self-reported non-cancer illnesses	1.0	1.7	5.5	-1.7	1.2	0.4	-0.2	-1.6	-2.3	-0.8	0.2	-2.3	-0.3
Medication: Atorvastatin	1.0	1.3	6.2	1.0	-0.8	2.5	-0.4	-0.2	-0.1	1.9	-0.2	-0.0	1.6
Heart disease (siblings)	1.0	1.2	3.8	-1.4	1.0	-1.9	0.6	-1.0	-1.3	-1.2	-0.4	-1.1	-1.0
Reaction Time	0.9	1.8	3.8	-0.1	1.9	1.9	1.5	-0.3	-1.0	1.1	1.5	-1.9	1.3
Qualifications: CSEs or equivalent	0.9	1.2	3.7	1.1	-1.6	-0.8	-1.9	0.8	0.9	-0.0	-0.2	1.7	0.9
Had menopause	0.9	1.1	3.1	0.1	-1.7	-1.2	-1.8	0.2	0.4	-1.2	-1.4	0.7	0.6
Qualifications: None of the above	0.9	1.9	5.2	1.2	-2.3	0.4	-2.2	1.0	1.6	-0.2	-0.4	1.9	1.2
High blood pressure (siblings)	0.9	1.4	3.0	0.2	-1.7	-1.4	-1.7	0.1	1.2	-1.2	-1.7	0.9	-0.6
Mouth/teeth dental problems: Loose teeth	0.9	1.0	3.2	-1.0	1.6	-0.3	1.8	-0.7	-1.0	-0.6	0.4	-1.5	-0.6
Neck or shoulder pain in last month	0.9	1.2	2.3	-1.4	0.3	-0.5	-0.8	-1.5	-1.5	-1.1	-1.1	-1.3	-1.3
Medication: Blood pressure	0.9	1.7	4.3	1.6	-1.1	1.9	-0.5	1.1	1.6	2.1	0.4	1.1	1.0
Commuting to job workplace: Walk	0.9	0.9	6.1	-0.5	-0.4	-2.5	-0.4	-0.1	0.1	-1.2	-1.1	0.3	-0.9
Osteoarthritis (self-reported)	0.9	1.1	3.2	-1.2	0.5	-0.6	0.7	-1.5	-1.6	-0.6	-0.7	-1.8	-0.8
Hearing aid user	0.9	1.0	2.3	-1.5	1.5	0.4	0.2	-0.8	-0.9	-0.9	1.0	-1.4	-1.0
Alcohol drinker status: Never	0.9	1.1	3.9	0.9	-0.8	2.0	1.5	0.1	0.5	1.2	0.5	0.4	1.4
Schizophrenia vs Biploar Disorder	0.8	1.1	2.3	1.4	-1.2	1.0	-0.7	1.0	1.5	1.3	0.2	1.5	0.5
Crohns Disease (2012)	0.8	1.3	3.2	1.6	-0.0	0.1	-0.6	1.6	1.8	0.6	1.5	1.6	0.7
Cardiovascular Disease	0.8	2.7	5.6	2.0	-2.1	0.5	-2.4	1.2	1.9	1.5	0.4	1.8	2.1
Lung FEV1/FVC ratio	0.8	4.0	10.6	2.1	-3.2	-0.0	-1.2	2.1	3.2	1.1	0.2	3.2	1.0
Hearing difficulty/problems: Yes	0.8	1.2	4.6	-1.1	2.1	-0.4	1.4	0.3	-0.4	-0.5	1.7	-1.2	-0.4
Medication: Levothyroxine sodium	0.8	1.4	6.4	-0.2	1.4	0.1	0.9	2.0	0.6	-0.4	2.5	-0.4	1.3
Chronic bronchitis/emphysema (father)	0.8	0.9	2.5	-1.3	0.1	-1.5	-0.4	-1.0	-1.0	-1.6	-0.7	-0.5	-0.5
Medication: Simvastatin	0.8	1.1	3.1	-0.7	1.8	1.3	0.8	-0.5	-1.4	0.5	1.0	-1.7	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	4.5	-1.1	2.1	0.2	-1.2	-0.6	-1.4	-0.6	1.2	-1.8	-0.6
Asthma	0.8	1.6	5.5	-1.4	2.3	0.7	0.6	-0.8	-1.7	-0.3	1.4	-1.8	-0.3
Length of working week for main job	0.8	0.8	3.0	0.2	-1.5	-0.7	-1.7	-0.3	-0.4	-0.5	-1.2	0.6	1.0
Blood clot in the leg (DVT)	0.8	1.0	2.4	-1.1	0.6	-1.4	-0.3	-1.2	-1.5	-1.1	-0.3	-1.4	-0.4
Mean time to correctly identify matches	0.8	1.4	3.8	0.0	1.4	2.0	1.5	-0.1	-0.7	1.3	1.4	-1.5	1.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.6	1.6	-0.7	0.6	0.3	1.4	0.9	1.5	1.2	0.9	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	3.3	-0.6	1.8	1.4	0.6	-0.1	-0.7	0.6	1.5	-1.1	0.3
Medication: Gliclazide	0.8	0.9	2.5	1.1	-1.5	0.7	-0.4	1.0	1.6	0.6	-0.6	1.1	0.7
Tinnitus: Yes, now most or all of the time	0.8	1.0	3.7	-1.3	0.6	0.0	0.3	-1.4	-0.9	-0.7	-1.0	-0.9	-1.9
Leg fat percentage (left)	0.8	3.0	9.6	2.0	-0.2	1.9	0.8	1.8	0.7	2.8	2.0	0.4	3.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.6	-1.0	0.5	-1.6	-0.8	-1.0	-1.4	-1.3	-0.2	-1.2	-0.2
Fasting Glucose	0.7	0.8	2.3	1.1	-0.5	0.8	-0.2	1.0	1.3	1.0	0.8	1.5	0.2
Triglycerides	0.7	1.2	3.6	-1.4	1.9	0.1	0.5	-0.3	-0.9	-0.9	1.2	-1.2	-1.5
Systolic Blood Pressure	0.7	3.7	7.0	2.6	-1.8	1.8	-2.1	1.6	1.5	1.9	1.6	2.0	2.7
Smoking Status	0.7	1.6	5.0	-1.6	1.7	0.3	0.5	-1.5	-1.9	-0.4	0.3	-2.2	-0.4
Financial difficulties in last 2 years	0.7	0.9	2.1	1.2	-0.8	1.1	-0.4	0.9	1.3	1.5	0.3	1.3	0.7
Tense / ‘highly strung’	0.7	1.2	4.0	-1.0	1.7	0.7	-0.1	-0.8	-1.3	-0.2	1.2	-2.0	1.1
Medication: Paracetamol	0.7	1.2	3.8	1.3	-1.3	-1.0	-0.5	1.7	1.0	0.2	0.2	1.0	1.9
Medication: Amlodipine	0.7	1.0	5.1	0.7	-1.4	-0.8	-2.2	0.4	0.8	0.1	-0.9	0.8	0.8
Comparative body size at age 10	0.7	1.9	6.1	-1.0	-0.8	-2.5	-1.4	-1.2	-1.4	-2.1	-1.9	-0.6	-0.1
Worry too long after embarrassment	0.7	1.2	4.7	-1.2	2.2	0.4	-0.1	-0.6	-1.1	-0.8	0.9	-1.5	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.7	-0.7	0.6	1.4	1.4	-0.6	0.4	0.7	0.1	0.0	-1.6
Qualifications: College or University degree	0.7	2.2	8.2	-1.3	2.0	0.3	2.9	-1.4	-1.1	-0.0	-0.2	-1.9	-1.9
Eye problems/disorders: None of the above	0.7	0.9	2.9	-1.4	1.0	-0.1	0.2	-1.2	-0.8	-1.1	-0.2	-0.6	-1.7
Medication: Ibuprofen	0.7	0.8	2.3	-1.4	0.3	-1.0	-0.5	-0.5	-0.9	-1.5	-1.0	-0.7	-0.9
Medication: Omeprazole	0.7	0.8	2.5	0.9	-0.3	1.6	0.7	0.7	0.5	1.5	0.7	0.4	1.2
Number of full sisters	0.7	0.9	3.2	0.1	-1.0	0.1	1.0	-0.4	0.8	0.0	-1.8	0.9	-1.6
Schizophrenia (2018)	0.6	1.3	3.9	-1.2	1.0	0.4	0.4	-2.0	-1.8	-0.2	-0.5	-1.4	-1.4
Alzheimer’s Disease (in father)	0.6	0.6	1.6	-1.0	-0.4	-1.0	-0.5	-0.6	-0.7	-1.1	-1.3	-0.2	-1.0
Irritable Bowel Disease (IBD)	0.6	1.5	3.9	2.0	-1.1	1.0	-0.6	1.1	1.3	1.6	0.4	1.8	1.0
Neuroticism (2016)	0.6	0.9	2.5	-0.7	1.6	-1.5	1.3	0.4	0.6	-1.0	0.8	-0.5	-0.9
Schizophrenia (2014)	0.6	1.3	2.5	-1.2	1.5	0.3	0.9	-1.6	-1.6	-0.3	-0.0	-1.4	-1.6
Hand grip strength (left)	0.6	1.7	5.4	1.1	-2.3	-0.6	-1.9	0.1	1.4	0.5	-1.6	1.8	0.2
High blood pressure (mother)	0.6	0.8	2.7	1.0	0.5	0.6	-0.1	1.3	0.8	0.6	1.6	0.5	1.4
Hair/balding pattern: Pattern 2	0.6	0.8	2.4	1.1	-0.6	0.0	-0.2	1.3	1.2	0.5	0.9	0.9	1.6
Heart attack	0.6	0.8	2.3	-1.3	1.4	0.4	0.1	-1.1	-0.8	-0.4	0.1	-1.5	-0.9
Hair/balding pattern: Pattern 3	0.6	0.9	2.2	0.6	1.1	0.9	1.2	0.7	1.3	1.0	1.5	0.5	-0.4
Noisy workplace	0.6	0.7	2.3	0.3	-0.8	-0.4	-1.5	0.9	1.3	-0.5	0.3	1.2	0.6
Prospective memory result	0.6	0.7	1.6	0.8	-1.3	-0.7	-1.2	0.7	0.9	-0.4	0.0	0.9	1.0
Pulse wave Arterial Stiffness index	0.6	0.7	2.9	0.5	-0.5	-0.3	-0.8	1.1	1.2	-0.5	1.0	1.7	0.2
Hair/balding pattern: Pattern 4	0.6	1.6	3.7	-1.9	0.8	-0.4	-0.9	-1.6	-1.7	-1.3	-0.4	-1.9	-0.9
Glaucoma (self-reported)	0.6	0.7	3.6	-0.8	-0.5	-0.1	-0.3	-1.9	-1.2	-0.3	-1.1	-0.6	-0.5
Gout (self-reported)	0.6	0.8	3.3	1.4	-0.4	0.7	-0.6	0.7	0.6	1.3	0.4	0.4	1.8
Migraine (self-reported)	0.6	0.7	2.3	-0.7	-0.4	-1.5	-0.3	-0.3	-0.9	-1.5	-1.1	-0.6	-0.2
Long-standing illness, disability or infirmity	0.6	0.8	3.4	-1.2	0.8	0.7	0.2	-1.0	-1.4	-0.5	0.0	-1.8	0.2
Asthma (self-reported)	0.6	1.2	4.2	-1.2	2.1	0.8	0.5	-0.7	-1.6	-0.1	1.2	-1.5	-0.3
Osteoporosis (self-reported)	0.6	0.8	3.0	1.1	0.1	0.1	0.1	0.9	0.5	0.7	1.7	0.2	1.7
Wears glasses or contact lenses	0.6	0.7	2.8	-0.5	-0.4	-1.3	0.1	-0.3	0.2	-0.7	-1.3	0.6	-1.7
Medication: Lisinopril	0.6	0.7	2.3	-0.8	1.0	1.5	0.5	-1.0	-1.2	0.5	0.1	-0.9	-0.3
Risk taking	0.6	0.9	2.8	0.4	-0.7	0.8	1.4	-1.1	0.1	1.4	-1.7	-0.2	-1.0
Myopia	0.6	0.8	2.2	1.5	-1.1	1.2	-1.1	0.4	0.4	1.3	0.2	0.9	0.7
Basal cell carcinoma (self-reported)	0.6	0.7	3.1	0.2	-1.6	0.2	-1.8	-0.4	-0.2	-0.2	-1.1	0.8	0.3
Bipolar Disorder or Schizophrenia	0.5	1.3	4.7	-1.1	1.1	-0.2	0.3	-1.8	-2.2	-0.5	-0.5	-1.7	-0.7
Neuroticism (Nagel 2018)	0.5	1.1	3.3	-1.0	1.8	-0.5	0.3	-0.2	-1.2	-0.9	1.3	-1.7	0.4
Breast Cancer	0.5	1.1	4.3	-0.7	2.1	0.6	1.8	-0.2	-0.2	0.2	1.4	-0.9	-1.2
Vitamin and mineral supplements	0.5	0.7	2.5	0.9	-1.6	0.7	0.4	0.3	0.9	1.1	-1.1	1.0	0.0
Multivitamins +/- minerals	0.5	0.6	1.8	-0.7	1.2	-1.1	-0.5	0.1	-0.7	-1.3	0.8	-0.4	-0.1
Nervous feelings	0.5	0.9	3.5	-0.3	0.8	0.2	-1.0	0.0	-0.7	-0.6	1.7	-0.6	1.9
Neuroticism score	0.5	1.0	3.4	-1.2	1.8	-0.7	0.3	-0.1	-0.5	-1.1	1.3	-1.5	-0.1
Falls in the last year	0.5	0.7	1.8	-1.1	1.0	0.5	0.1	-0.7	-1.4	-1.0	0.1	-1.1	-0.8
Medication: Lansoprazole	0.5	0.6	2.4	0.7	-0.4	1.6	-0.1	0.6	0.2	1.0	0.9	0.3	0.9
Exposure to tobacco smoke at home	0.5	0.6	1.1	-1.0	-0.2	0.6	-0.7	-0.8	-1.0	-0.8	-0.8	-1.0	-0.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.9	1.1	0.2	0.5	-0.3	1.4	1.0	1.0	1.0	0.8	0.7
Headache pain in last month	0.5	0.8	3.0	-1.0	-0.2	-0.8	-1.1	-0.5	-1.4	-1.7	-0.7	-0.2	-0.9
Medication: Seretide 50 evohaler	0.5	0.5	1.6	1.1	-1.0	-0.6	-0.5	0.9	0.5	0.2	-0.5	1.3	0.5
Knee pain experienced in last month	0.5	0.8	1.6	0.9	-0.9	1.0	0.7	1.1	1.3	1.0	0.0	1.1	-0.5
Diabetes diagnosed by doctor	0.5	0.8	4.5	0.7	-0.7	2.1	0.3	0.2	0.5	1.4	-0.4	-0.2	0.8
Medication for cholesterol	0.5	0.8	2.3	0.9	-0.2	0.7	1.5	0.9	1.2	0.9	0.4	1.2	-0.6
Commuting to job workplace: Public transport	0.5	0.6	2.1	-0.6	0.7	-1.5	0.7	-0.5	-0.7	-0.8	-0.5	-0.9	-0.4
Medication: Blood pressure	0.5	1.0	3.6	1.0	-1.5	-0.1	-1.9	0.1	0.5	0.3	-0.3	0.4	1.8
Ever smoked	0.5	0.8	2.4	-1.5	0.7	-0.2	0.1	-1.0	-1.3	-1.1	-0.2	-1.1	-1.1
Ever depressed for a whole week	0.5	0.6	1.4	-1.2	0.8	-0.2	-0.1	-0.8	-0.8	-1.0	-0.4	-0.9	-1.0
Cholesterol lowering medication	0.5	0.7	3.6	0.1	0.2	-0.0	-1.2	0.4	-0.8	-0.2	0.7	-1.0	1.9
Pain experienced in last month	0.5	0.8	2.3	1.1	-0.4	-0.1	0.6	1.0	1.4	0.9	0.6	0.6	1.5
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.6	-1.4	1.1	-1.2	0.3	-1.2	-1.6	-1.3	-0.4	-1.6	-0.9
Alzheimer’s Disease (in mother)	0.4	0.4	0.9	-0.7	0.9	0.7	0.2	-0.9	-0.8	-0.0	0.2	-0.8	-0.9
Waist Hip Ratio (WHR)	0.4	1.9	4.6	-1.9	1.2	-1.6	-1.0	-0.9	-1.7	-2.1	0.3	-1.9	-0.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.9	-1.0	0.9	-0.7	-0.4	-0.5	-0.8	-0.9	0.5	-0.9	-0.3
Medication: Co-codamol	0.4	0.5	2.1	0.8	-0.0	1.0	0.7	-0.3	0.3	1.5	0.7	0.0	0.5
Maternal smoking around birth	0.4	0.6	2.4	-0.6	-0.1	-1.4	-1.6	-0.4	-0.3	-0.8	-0.7	0.1	-0.9
Stomach or abdominal pain in last month	0.4	0.4	0.9	-0.9	0.9	0.6	0.9	-0.1	-0.8	-0.6	0.6	-0.6	-0.6
Diabetes (self-reported)	0.4	0.6	3.5	0.5	-0.1	1.9	1.0	0.3	0.3	1.1	0.0	-0.5	0.7
Lung cancer (father)	0.4	0.5	1.7	-0.9	0.2	-0.5	-0.7	-0.6	-0.8	-1.3	-0.6	-0.3	-0.6
Pulse wave reflection index	0.4	0.5	1.5	0.9	-0.1	0.6	0.0	1.2	1.1	0.6	0.7	1.2	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	-0.7	-0.0	0.8	0.6	-1.0	-0.9	0.1	-1.0	-0.9	-0.2
Pulse wave peak to peak time	0.4	0.5	1.8	-0.2	-0.2	0.1	0.3	-1.0	-0.9	0.4	-1.3	-1.3	-0.0
Emphysema/chronic bronchitis	0.4	0.5	1.3	-0.4	-0.7	-0.7	-1.1	-0.5	-0.7	-0.8	-1.2	-0.5	0.1
Medication: Allopurinol	0.4	0.5	2.0	1.2	-0.8	0.2	-0.5	0.6	0.5	0.8	-0.2	0.4	1.4
Suffer from ‘nerves’	0.4	0.6	1.7	0.6	-0.5	0.9	-1.3	0.8	0.5	0.4	0.9	0.8	1.2
Illnesses of father: Heart disease	0.4	0.5	2.7	-0.3	1.6	-0.2	0.3	-0.1	-0.7	-0.2	1.1	-1.2	0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.2	-0.7	0.9	-1.1	-0.9	-0.1	-0.2	-1.1	1.1	-0.2	-0.1
Number of operations (self-reported)	0.4	0.6	1.4	-1.1	0.6	-0.7	-0.8	-0.9	-1.0	-1.2	-0.2	-0.9	-0.6
Commuting to job workplace: Cycle	0.4	0.5	1.5	-0.6	1.1	-0.4	1.1	0.6	0.3	-0.6	1.2	-0.1	-0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	-1.0	1.2	0.7	0.1	-0.8	-0.4	-0.1	0.3	-1.2	-0.6
Bipolar Disorder (2018)	0.3	0.4	1.5	-0.3	0.6	-0.8	0.1	-0.4	-1.2	-0.6	0.1	-1.0	0.8
Depressed Affect (Nagel 2018)	0.3	0.6	2.2	-0.0	1.1	0.1	1.1	0.5	0.1	0.2	1.5	-0.8	0.8
Depression (Nagel 2018)	0.3	0.5	1.3	-0.2	1.1	0.1	0.8	-0.0	-0.6	0.5	1.0	-1.2	0.5
Worry (Nagel 2018)	0.3	0.6	3.2	0.1	0.3	-0.7	-1.1	0.2	-0.6	-0.5	1.0	-0.6	1.8
Mean Putamen Volume	0.3	0.3	1.2	-0.6	1.1	-0.6	0.4	-0.1	-0.4	0.0	0.7	-0.9	0.5
HDL Cholesterol	0.3	0.5	2.4	-0.2	-1.0	-0.8	-0.3	-1.0	-0.7	-0.6	-1.6	-0.0	0.1
Neuroticism	0.3	0.7	1.8	-1.1	1.4	-0.9	0.1	-0.1	-0.4	-1.3	0.6	-1.1	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	2.7	-0.1	0.7	1.4	1.6	-0.2	-0.1	0.6	0.5	-0.7	-0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.0	-1.0	0.6	0.4	-0.6	-0.9	-0.7	-0.6	-0.3	-0.9	-0.5
Illnesses of siblings	0.3	0.5	2.1	0.2	1.0	0.9	0.2	0.3	-0.2	0.6	1.4	-0.1	0.6
Father’s age at death	0.3	0.4	1.2	-0.8	1.1	-0.4	0.7	-0.5	0.0	-0.3	0.1	-0.8	-1.0
Worrier / anxious feelings	0.3	0.5	1.9	-0.3	0.8	-1.4	-0.3	0.5	0.0	-1.1	0.9	-0.4	0.5
Pulse rate	0.3	0.5	3.0	-0.2	-0.9	-1.0	-1.7	-0.4	0.2	-0.7	-0.3	0.5	0.2
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.9	0.0	1.2	1.4	1.2	-0.0	-0.3	0.8	0.7	-0.5	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.7	0.8	-0.2	0.1	0.2	1.3	0.5	0.4	0.5	0.8	0.8
Medication: Cholesterol lowering	0.3	0.5	2.8	0.2	0.1	1.7	0.1	-0.6	-0.5	1.2	-0.1	-0.3	-0.1
Depression (self-reported)	0.3	0.4	1.3	-0.2	-0.8	-1.1	-0.6	-0.3	-0.1	-0.6	-1.1	0.2	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.4	-1.0	1.2	0.6	1.0	-0.5	-0.3	-0.4	0.3	-1.1	-0.3
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.8	-0.5	-0.2	-1.3	-0.2	-0.2	0.4	-0.6	-0.8	-0.4	-0.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.6	-0.7	0.7	-1.1	0.5	-0.1	-0.6	-1.3	0.0	-0.4	-0.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.9	-0.7	0.0	-0.2	-0.5	-0.9	-1.0	-0.8	-0.3	-0.6	-0.1
Mood swings	0.3	0.5	1.6	-0.6	1.3	0.1	1.0	0.6	0.5	-0.7	0.7	-0.6	-0.5
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.8	0.4	-0.4	0.7	-0.1	-0.4	0.6	1.3	-0.4	0.4	-0.5
Fractured/broken bones in last 5 years	0.3	0.4	1.3	-0.4	1.2	-0.2	0.6	0.0	-0.5	-0.7	0.8	-1.0	0.4
Ulcerative Colitis (UC)	0.2	0.4	1.0	0.9	-1.0	-0.0	-0.5	0.3	0.5	0.7	-0.9	1.0	-0.0
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.5	-0.1	1.1	-0.5	1.2	-0.0	-0.8	0.3	0.3	-1.0	0.1
Coronary Artery Disease (CAD)	0.2	0.3	1.5	-0.3	-0.7	-0.7	0.1	-0.3	-0.1	0.0	-1.2	0.1	-0.8
Heel T-Score	0.2	1.6	2.8	1.5	-0.8	1.6	0.8	1.1	1.0	1.6	1.7	1.3	1.4
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.5	0.3	-0.1	1.2	-0.2	0.3	0.1	0.2	0.3	-0.4	1.2
Ever had hysterectomy (womb removed)	0.2	0.3	0.9	-0.3	-0.4	0.2	0.7	-0.1	-0.1	-1.0	-0.6	0.5	-0.8
Angina	0.2	0.2	0.5	-0.5	0.7	0.2	0.5	-0.7	-0.6	-0.0	0.1	-0.7	-0.4
Medication: Metformin	0.2	0.3	1.5	0.2	0.2	1.2	0.5	-0.2	-0.1	0.6	0.3	-0.8	0.9
Diabetes (father)	0.2	0.3	1.0	-0.2	-0.7	0.5	-0.3	-1.0	-0.6	0.1	-0.8	-0.6	-0.2
Current tobacco smoking	0.2	0.4	1.6	-0.3	0.6	0.3	-0.9	0.4	-0.3	-0.2	0.9	-0.6	1.3
Fed-up feelings	0.2	0.3	1.3	-0.5	0.3	-1.0	-0.6	0.5	0.2	-1.2	0.3	-0.2	0.3
Taking other prescription medications	0.2	0.3	0.9	-0.4	0.7	0.5	0.6	0.5	-0.6	-0.3	0.9	-0.8	0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.7	0.0	-0.7	0.4	-0.5	-0.4	-0.1	-0.6	-0.6	0.5	-0.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.6	-0.5	0.8	-0.5	-0.2	-0.0	-0.6	-0.8	0.7	-0.6	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	2.8	-0.0	0.2	0.9	1.7	-0.4	-0.0	0.5	0.1	-0.4	-0.5
Allergy	0.2	0.6	2.6	0.5	-1.3	-0.1	0.1	0.5	1.6	0.2	-0.6	0.9	0.0
Medication: Ramipril	0.2	0.2	0.7	0.4	-0.5	0.4	-0.8	-0.2	0.3	0.4	0.4	0.5	0.6
Number of live births	0.2	0.3	1.0	-0.3	0.5	0.7	0.1	-0.1	-0.4	-0.2	0.8	-1.0	0.8
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	0.1	0.7	0.7	0.5	0.3	-0.1	0.5	0.9	-0.5	0.6
Illnesses of mother	0.2	0.2	0.8	0.2	-0.8	-0.7	-0.0	0.1	0.4	-0.2	-0.3	0.9	-0.4
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.1	0.4	-0.9	0.5	-1.0	-0.1	-0.0	0.2	-0.5	0.4	0.5
Medication for pain relief, constipation, heartburn	0.2	0.3	0.9	-0.4	1.0	0.1	0.2	-0.8	-0.5	-0.1	0.6	-0.6	-0.6
Overall health rating	0.2	0.4	2.9	0.3	0.1	1.7	-0.0	0.4	-0.0	0.8	0.4	-0.2	0.5
Leg pain on walking	0.2	0.3	0.8	0.2	0.4	-0.2	0.8	0.9	0.1	-0.2	0.9	-0.1	0.9
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.9	-0.2	-0.2	-0.1	-0.2	-0.7	-0.9	-0.3	-0.4	-0.5	0.6
Supplements: Vitamin C	0.2	0.3	1.0	0.4	-1.0	-0.4	-0.8	0.0	0.8	-0.4	-0.1	0.5	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.8	0.5	-0.1	0.3	0.5	0.4	0.4	0.9	0.1	0.5	-0.0
Average weekly red wine intake	0.2	0.3	1.8	-0.0	0.3	-0.5	1.4	-0.4	0.4	0.5	-0.2	-0.3	-0.8
Medication: Aspirin	0.2	0.2	0.6	0.7	-0.2	0.5	0.4	0.5	0.6	0.8	0.1	-0.3	0.7
Miserableness	0.2	0.3	1.0	-0.9	0.6	-0.1	-0.5	-0.5	-0.3	-1.0	0.2	-0.3	-0.8
High cholesterol (Self-reported)	0.2	0.4	0.9	-0.3	0.7	0.6	-0.7	-0.1	-0.8	0.1	0.8	-0.9	0.7
Illnesses of father: High blood pressure	0.2	0.3	0.8	-0.7	0.4	-0.1	-0.9	-0.7	-0.7	-0.7	0.3	-0.4	-0.1
Unable to work because of sickness or disability	0.2	0.2	0.9	-0.4	0.8	0.9	0.2	-0.1	0.0	0.2	0.5	-0.6	0.4
Ovarian Cancer	0.1	0.2	0.7	0.0	-0.4	0.5	0.2	0.1	0.6	0.1	-0.6	0.2	-0.8
Lupus	0.1	0.2	0.9	-0.4	0.6	0.2	0.3	-0.2	-0.4	0.3	-0.4	-0.1	-1.0
Ulcerative Colitis	0.1	0.2	0.5	0.6	-0.2	-0.3	-0.6	0.4	0.4	0.7	-0.4	0.6	-0.1
Allergy or Eczema	0.1	0.3	1.2	0.1	0.2	-1.0	-1.1	0.2	-0.4	-0.6	0.1	0.8	-0.7
Hair Pigment	0.1	1.9	6.2	-1.8	-0.4	-1.3	-1.8	-0.8	-0.9	-2.5	-1.5	-0.4	-1.7
Number of treatments/medications taken	0.1	0.2	0.7	-0.6	-0.3	-0.1	-0.6	-0.3	-0.6	-0.5	-0.4	-0.8	0.4
Average weekly spirits intake	0.1	0.1	0.5	-0.4	0.1	-0.4	-0.6	-0.1	0.4	-0.4	-0.2	-0.0	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	-0.3	-0.2	0.0	0.1	-0.5	-0.1	0.2	-0.5	-0.6	-0.3
Serious illness, injury or assault to yourself	0.1	0.2	0.8	-0.0	0.3	0.9	0.4	-0.2	-0.2	0.5	0.2	-0.7	0.2
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.6	0.2	-0.2	-0.7	0.6	-0.2	0.2	0.5	0.7	0.0
Fluid intelligence score	0.1	0.2	0.7	-0.1	0.8	0.3	0.8	-0.1	-0.1	0.5	0.2	-0.7	-0.5
Exposure to tobacco smoke outside home	0.1	0.2	1.1	-0.3	0.4	1.0	-0.0	-0.0	-0.1	-0.1	0.8	-0.2	0.0
Angina (self-reported)	0.1	0.1	0.3	-0.3	0.4	0.1	0.4	-0.6	-0.5	0.1	-0.1	-0.4	-0.2
Pulse rate, automated reading	0.1	0.4	2.0	0.2	-0.1	0.1	-1.0	0.3	0.3	0.3	0.9	-0.1	1.4
Medication: Aspirin	0.1	0.1	0.2	0.4	-0.1	0.4	0.2	0.3	0.5	0.4	-0.0	-0.2	0.3
Loneliness, isolation	0.1	0.1	0.3	-0.2	0.5	0.3	0.3	-0.6	-0.1	0.4	0.2	-0.6	-0.2
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.1	0.4	-0.5	0.3	0.3	-0.4	-0.1	-0.0	-0.4	0.3
Breast cancer (self-reported)	0.1	0.1	0.6	-0.0	-0.2	0.8	0.0	-0.2	-0.5	0.3	-0.4	-0.0	-0.0
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	-0.3	-0.2	-0.2	-0.0	-0.2	-0.2	-0.5	-0.6	0.2	-0.7
Smoking status: Current	0.1	0.2	1.2	-0.2	0.1	0.1	-1.0	0.2	-0.2	-0.3	0.3	-0.4	1.1
Financial situation satisfaction	0.1	0.1	0.4	-0.3	0.1	-0.1	0.6	-0.2	0.4	0.0	-0.4	-0.5	-0.2
Eye problems/disorders: Glaucoma	0.1	0.2	1.0	-0.3	0.1	0.3	0.5	-1.0	-0.3	0.4	-0.3	-0.4	0.0
Age started oral contraceptive pill	0.1	0.1	0.5	-0.3	0.7	0.4	0.3	0.5	0.3	-0.2	0.5	-0.4	-0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.3	1.2	0.3	-0.8	0.2	-0.3	-0.1	-0.4	0.3	-1.1	0.3	0.6

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