TWAS hub - ZBTB24

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.1060	0.0470	6.1e-04	0.114	NA	0.080	NA	0.096	1.0e-05	NA	2.0e-04	NA	4.9e-05
2	ROSMAP	Brain Pre-frontal Cortex	0.0310	0.0166	5.4e-03	0.003	0.005	-0.002	0.004	0.003	1.4e-01	7.3e-02	6.3e-01	0.1	1.1e-01
3	TCGA	Brain Lower Grade Glioma	0.0365	0.0179	4.4e-06	0.053	0.041	0.038	NA	0.044	1.2e-06	1.6e-05	3.7e-05	NA	7.8e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Sitting height	16.2	114.7	146.4	11.0	8.8	12.1
Leg fat-free mass (right)	12.6	67.1	79.0	8.1	7.5	8.9
Forced expiratory volume in 1-second (FEV1)	12.3	41.5	53.7	6.7	5.1	7.3
Leg predicted mass (right)	12.3	65.9	77.9	8.0	7.4	8.8
Leg fat-free mass (left)	12.0	63.4	74.3	7.9	7.3	8.6
Whole body water mass	12.0	68.7	83.0	8.2	7.5	9.1
Whole body fat-free mass	11.9	68.3	82.6	8.1	7.5	9.1
Leg predicted mass (left)	11.7	61.9	73.0	7.8	7.2	8.5
Trunk fat-free mass	11.6	66.4	81.7	8.0	7.3	9.0
Forced expiratory volume in 1-second (FEV1), Best measure	11.5	36.6	44.8	6.3	5.0	6.7
Trunk predicted mass	11.5	65.7	80.6	8.0	7.3	9.0
Peak expiratory flow (PEF)	11.5	26.6	32.7	5.5	4.1	5.7
Basal metabolic rate	11.4	63.0	74.8	7.8	7.3	8.7
Arm predicted mass (right)	11.3	57.9	71.9	7.4	6.9	8.5
Arm fat-free mass (right)	11.2	57.7	72.6	7.3	6.8	8.5
Arm fat-free mass (left)	10.8	55.0	68.1	7.2	6.8	8.2
Arm predicted mass (left)	10.5	53.3	65.8	7.0	6.7	8.1
Forced vital capacity (FVC)	10.2	39.2	51.7	6.4	5.0	7.2
Height	9.8	188.3	225.0	14.0	12.0	15.0
Forced vital capacity (FVC), Best measure	9.0	32.9	41.3	5.8	4.9	6.4
Standing height	8.2	81.0	106.1	9.0	7.5	10.3
Weight	8.0	39.4	44.1	6.2	6.0	6.6
Bipolar Disorder (2011)	7.6	7.3	8.4	-2.9	-2.6	-2.6
Friendships satisfaction	7.5	9.3	12.4	-2.8	-3.5	-2.7
Alcohol intake frequency.	6.9	16.0	18.3	3.8	4.3	3.9
Birth weight	6.8	14.7	21.8	3.3	3.4	4.7
Family relationship satisfaction	6.8	8.3	10.0	-2.5	-3.2	-3.0
Happiness	6.7	8.2	13.7	-2.3	-3.7	-2.4
Average weekly fortified wine intake	6.0	7.0	8.5	-2.6	-2.9	-2.4
Age when periods started (menarche)	6.0	14.3	16.4	4.0	3.4	3.9
LDL Cholesterol	5.8	9.2	10.4	-3.2	-2.6	-3.2
Body Mass Index (BMI) (2010)	5.7	7.9	9.9	3.1	2.9	2.3
Blood Eosinophil Count	4.8	37.2	39.4	-5.8	-6.3	-6.2
Hip circumference	4.8	20.8	22.2	4.7	4.4	4.6
Age at first live birth	4.8	8.5	8.6	-2.9	-2.9	-2.9
Comparative height size at age 10	4.8	26.6	32.7	4.8	4.9	5.7
Guilty feelings	4.8	7.3	8.5	-2.5	-2.9	-2.7
Wheeze or whistling in the chest in last year	4.7	8.4	10.3	-3.0	-2.4	-3.2
Impedance of leg (left)	4.6	22.2	24.2	-4.8	-4.4	-4.9
Respiratory disease	4.5	9.9	12.7	-3.4	-2.3	-3.6
Medication: Atenolol	4.5	5.6	6.4	2.4	2.5	2.2
Ever had bowel cancer screening	4.4	5.1	5.9	-2.4	-2.2	-2.1
Impedance of leg (right)	4.3	20.7	22.8	-4.6	-4.3	-4.8
Tinnitus: Yes, but not now, but have in the past	4.3	4.6	5.6	-1.7	-2.4	-2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.3	5.1	6.1	-2.4	-1.8	-2.5
Hand grip strength (right)	4.2	11.5	15.2	3.6	2.5	3.9
Supplements: Glucosamine	4.2	5.5	6.3	-2.5	-2.3	-2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.2	8.9	10.4	3.2	2.5	3.2
Ever taken oral contraceptive pill	4.2	4.7	6.1	-1.7	-2.5	-2.3
Impedance of whole body	4.1	20.9	24.9	-4.4	-4.3	-5.0
Blood Platelet Count	4.0	46.3	48.2	-6.6	-6.9	-6.9
Chronotype (morning person)	4.0	9.3	12.6	3.1	3.6	2.4
Age at last live birth	4.0	5.9	7.6	-2.2	-2.2	-2.8
Had major operations	3.9	4.5	6.0	2.4	1.7	2.2
Sensitivity / hurt feelings	3.8	6.5	6.8	-2.6	-2.6	-2.5
Medication for hormone replacement therapy	3.8	4.3	5.3	-2.1	-2.3	-1.8
Diabetes (mother)	3.8	4.9	5.3	2.1	2.3	2.3
Had other major operations	3.8	4.7	7.0	-2.6	-1.4	-2.2
Age at First Birth	3.7	5.4	7.4	-2.1	-2.7	-2.1
Illnesses of siblings: Diabetes	3.7	4.5	5.6	2.1	2.4	1.9
Handedness (chirality/laterality): Left-handed	3.7	4.5	4.8	2.2	2.2	2.0
Lung FVC	3.6	18.1	23.0	4.3	3.6	4.8
Hearing difficulty/problems with background noise	3.5	5.5	7.3	-2.2	-2.7	-2.1
Major Depression (MDD)	3.4	4.1	5.6	-2.4	-1.4	-2.1
Chest pain or discomfort	3.4	5.0	5.8	-2.4	-2.1	-2.2
Other serious medical condition/disability diagnosed by doctor	3.3	4.3	5.4	-2.3	-1.7	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	3.3	6.8	10.6	2.5	1.8	3.3
Irritability	3.3	5.5	7.3	-2.7	-2.1	-2.2
Alcohol intake versus 10 years previously	3.2	4.8	5.2	2.2	2.1	2.3
Pain type(s) experienced in last month: Hip pain	3.2	4.0	5.5	-2.0	-1.6	-2.4
Rheumatoid Arthritis	3.1	4.2	5.2	1.7	2.1	2.3
Trunk fat mass	3.1	13.3	14.1	3.6	3.8	3.6
Hearing difficulty/problems: Yes	3.0	4.5	5.5	-1.8	-2.4	-2.2
Arm fat mass (right)	2.9	11.8	14.2	3.4	3.8	3.1
Worry too long after embarrassment	2.9	4.8	7.0	-1.7	-2.7	-2.1
Health satisfaction	2.9	3.8	4.7	-1.8	-2.2	-1.9
Medication: Bendroflumethiazide	2.9	4.3	4.8	2.0	2.2	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.8	3.3	3.9	-1.5	-2.0	-1.9
Arm fat mass (left)	2.8	11.4	13.0	3.4	3.6	3.1
Hypothyroidism (self reported)	2.7	6.2	7.8	-2.8	-1.9	-2.6
Impedance of arm (left)	2.7	12.5	16.2	-3.2	-3.4	-4.0
Length of working week for main job	2.7	2.9	4.9	1.0	2.2	1.7
Hypothyroidism/myxoedema (self-reported)	2.7	5.3	6.2	-2.5	-2.0	-2.4
Number of children fathered	2.7	3.0	4.4	1.8	1.2	2.1
Waist circumference	2.6	9.4	10.3	3.1	3.2	2.9
Alcohol usually taken with meals	2.6	4.2	4.8	-2.0	-2.0	-2.2
Whole body fat mass	2.6	10.7	11.8	3.2	3.4	3.2
Leg fat mass (left)	2.6	10.3	12.2	3.1	3.5	3.1
Primary Biliary Cirrhosis	2.5	3.6	3.8	-2.0	-1.8	-1.9
Leg fat mass (right)	2.5	9.7	11.3	3.0	3.4	3.0
Neuroticism score	2.4	5.0	7.9	-1.9	-2.8	-1.9
Blood White Count	2.3	17.4	20.3	-4.5	-4.3	-3.6
Qualifications: None of the above	2.3	4.8	5.1	2.1	2.3	2.2
Impedance of arm (right)	2.3	10.7	14.8	-3.0	-2.9	-3.8
Basal cell carcinoma (self-reported)	2.3	2.8	4.4	1.3	2.1	1.5
Alzheimer’s Disease (including proxy)	2.2	3.2	5.8	-1.4	-2.4	-1.4
Relative age voice broke	2.2	3.3	7.1	-1.4	-2.7	-0.9
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.5	4.8	-1.8	-1.6	-2.2
Heart disease (mother)	2.2	2.7	4.5	-2.1	-1.5	-1.1
Myopia	2.2	3.2	6.3	1.5	2.5	1.0
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.3	4.2	-1.9	-2.0	-1.4
Asthma	2.1	4.1	5.7	-2.2	-1.3	-2.4
Tense / ‘highly strung’	2.1	3.5	4.4	-2.1	-1.9	-1.5
Medication: Ventolin 100micrograms inhaler	2.1	2.7	4.1	-1.6	-1.1	-2.0
Hypertension (Self-reported)	2.1	6.0	6.4	2.5	2.5	2.3
Mouth/teeth dental problems: Loose teeth	2.0	2.3	2.7	-1.5	-1.5	-1.6
Illnesses of father: Heart disease	2.0	2.7	3.3	-1.8	-1.4	-1.7
Back pain experienced in last month	2.0	2.9	3.2	-1.8	-1.6	-1.8
Hearing aid user	2.0	2.2	2.4	-1.5	-1.4	-1.6
Severe depression (siblings)	1.9	2.1	3.3	-1.4	-1.8	-1.1
Qualifications: CSEs or equivalent	1.9	2.4	2.7	1.6	1.6	1.5
Diastolic blood pressure, automated reading	1.9	6.0	8.8	2.2	3.0	2.2
Schizophrenia vs Biploar Disorder	1.8	2.4	3.3	1.8	1.6	1.1
High blood pressure	1.8	5.0	5.5	2.3	2.4	2.1
Neuroticism (Nagel 2018)	1.7	4.0	5.4	-1.8	-2.3	-1.8
Neuroticism (2016)	1.7	2.5	3.7	-1.2	-1.9	-1.5
Triglycerides	1.7	2.9	3.2	-1.6	-1.8	-1.7
Hand grip strength (left)	1.7	4.4	5.4	2.3	1.6	2.3
Supplements: Zinc	1.7	1.8	2.3	-1.5	-1.5	-1.0
Body mass index (BMI)	1.7	7.1	8.9	2.6	3.0	2.4
Qualifications: nursing, teaching	1.7	2.7	3.1	-1.6	-1.8	-1.5
Blood Red Count	1.6	15.9	27.8	3.8	5.3	2.3
Smoking Status	1.6	3.8	4.4	-2.0	-2.1	-1.7
Systolic blood pressure, automated reading	1.6	4.7	7.2	1.8	2.7	1.9
Past tobacco smoking	1.6	2.9	3.9	2.0	1.5	1.6
Had menopause	1.6	2.1	2.8	1.1	1.5	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.5	4.4	-1.2	-2.1	-1.3
Mood swings	1.6	2.9	5.6	-1.1	-2.4	-1.4
Commuting to job workplace: Cycle	1.6	1.9	3.1	-0.8	-1.8	-1.4
Reaction Time	1.5	2.9	3.5	-1.9	-1.4	-1.8
Mean Putamen Volume	1.5	1.7	2.5	-1.2	-1.6	-1.1
Lung FEV1/FVC ratio	1.5	7.5	10.2	3.2	1.5	3.2
Medication: Simvastatin	1.5	2.2	2.9	-1.7	-1.1	-1.6
Birth weight of first child	1.5	2.7	3.8	1.7	1.2	1.9
Asthma (self-reported)	1.5	3.0	4.4	-1.9	-1.0	-2.1
Medication: Blood pressure	1.5	2.9	5.0	0.9	2.2	1.7
Cardiovascular Disease	1.4	4.5	5.2	2.0	2.1	2.3
Vitamin and mineral supplements	1.4	1.9	2.0	1.3	1.4	1.4
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	2.1	-1.5	-1.1	-1.4
Medication: Seretide 50 evohaler	1.4	1.6	2.1	1.2	1.4	1.1
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	2.7	1.2	1.7	0.9
Medication: Gliclazide	1.4	1.5	2.0	1.4	0.8	1.4
Heart disease (siblings)	1.4	1.7	2.9	-1.3	-1.7	-0.9
Neuroticism	1.3	3.2	5.5	-1.4	-2.3	-1.4
Frequency of depressed mood in last 2 weeks	1.3	1.8	3.6	-1.0	-1.9	-0.9
Townsend deprivation index at recruitment	1.3	1.8	2.2	1.5	1.3	1.2
Mouth/teeth dental problems	1.3	2.0	3.1	1.8	0.5	1.7
Medication: Amlodipine	1.3	1.8	2.0	1.2	1.4	1.4
Smoking status: Previous	1.3	1.9	2.2	-1.4	-1.2	-1.5
Mineral and other dietary supplements	1.3	1.7	2.0	1.4	1.1	1.4
Vascular/heart problems diagnosed by doctor	1.3	3.5	4.8	-1.8	-2.2	-1.5
Irritable Bowel Disease (IBD)	1.2	2.7	4.0	1.8	2.0	0.9
HbA1C	1.2	1.3	1.9	1.4	1.4	0.3
Heart attack	1.2	1.5	1.9	-1.3	-0.9	-1.4
High blood pressure (siblings)	1.2	1.7	2.8	1.4	0.6	1.7
Qualifications: College or University degree	1.2	3.9	4.9	-1.7	-2.2	-2.0
Mother’s age at death	1.2	1.4	2.3	-1.5	-1.1	-0.9
Fractured/broken bones in last 5 years	1.2	1.5	1.7	-1.3	-1.1	-1.3
Breast Cancer	1.1	2.6	3.6	-1.3	-1.6	-1.9
Medication: Levothyroxine sodium	1.1	1.9	2.9	-1.3	-1.0	-1.7
Time employed in main current job	1.1	1.3	1.5	1.1	1.2	1.2
Prospective memory result	1.1	1.3	1.6	0.9	1.2	1.3
Ever depressed for a whole week	1.1	1.4	2.5	-0.9	-1.6	-0.9
Schizophrenia (2014)	1.0	2.2	3.0	-1.1	-1.7	-1.6
Systolic Blood Pressure	1.0	4.9	7.6	1.8	2.8	2.0
Father’s age at death	1.0	1.3	1.5	-1.1	-1.2	-1.1
Falls in the last year	1.0	1.3	1.7	-1.1	-1.3	-1.1
Illnesses of mother	1.0	1.3	1.8	1.2	1.3	0.8
Breastfed as a baby	1.0	1.2	2.6	0.8	0.7	1.6
Mean time to correctly identify matches	1.0	2.0	2.1	-1.4	-1.4	-1.5
Medication: Paracetamol	1.0	1.5	1.9	1.3	1.4	0.9
Depression (Nagel 2018)	0.9	1.4	1.6	-1.1	-1.3	-1.2
Multivitamins +/- minerals	0.9	1.1	1.5	-0.9	-1.2	-1.1
Pain all over the body in last month	0.9	1.0	1.7	0.6	1.0	1.3
Medication: Blood pressure	0.9	1.6	1.8	1.4	1.3	1.1
Crohns Disease (2017)	0.8	1.8	2.9	1.4	1.7	0.6
Fasting Glucose	0.8	0.9	1.9	1.4	0.8	0.4
Medication: Paracetamol	0.8	1.3	1.6	1.3	1.2	1.0
Eye problems/disorders: None of the above	0.8	0.9	1.4	-0.7	-0.9	-1.2
Number of self-reported non-cancer illnesses	0.8	1.5	2.5	-1.6	-0.7	-1.2
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.4	-1.0	-0.7	-1.2
Depressed Affect (Nagel 2018)	0.7	1.5	2.0	-1.0	-1.4	-1.2
Alzheimer’s Disease (in mother)	0.7	0.9	0.9	-0.9	-1.0	-0.9
Ulcerative Colitis (UC)	0.7	1.4	1.8	1.3	1.3	0.8
Current tobacco smoking	0.7	1.1	1.8	-1.0	-1.3	-0.7
Stomach or abdominal pain in last month	0.7	0.9	1.2	-0.8	-0.9	-1.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.0	-0.9	-1.0	-0.9
Worrier / anxious feelings	0.7	1.3	2.7	-0.8	-1.6	-0.8
Hair/balding pattern: Pattern 4	0.7	1.7	2.4	-1.5	-1.4	-0.8
Number of full sisters	0.7	0.9	1.4	1.2	0.7	0.9
Long-standing illness, disability or infirmity	0.7	1.1	1.9	-1.4	-0.7	-1.0
Commuting to job workplace: Public transport	0.7	0.8	1.1	-0.9	-1.0	-0.8
Alcohol drinker status: Never	0.7	0.9	1.6	0.7	1.3	0.7
Average weekly beer plus cider intake	0.7	1.1	1.5	1.2	0.9	0.9
Bipolar Disorder or Schizophrenia	0.6	1.5	1.7	-1.3	-1.3	-1.1
Waist Hip Ratio (WHR)	0.6	2.6	3.6	-1.9	-1.6	-1.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	0.8	0.8	0.8	0.9
Trunk fat percentage	0.6	2.5	3.6	1.5	1.9	1.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.2	0.5	1.1	0.8
Nervous feelings	0.6	1.2	1.7	-1.1	-1.3	-0.8
Financial difficulties in last 2 years	0.6	0.8	1.5	1.2	0.5	0.8
Medication: Ramipril	0.6	0.8	1.9	0.5	1.4	0.6
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.0	0.6	0.8	1.0
Shortness of breath walking on level ground	0.6	0.7	1.3	-0.3	-0.8	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.6	1.0	1.3	0.6
Unable to work because of sickness or disability	0.6	0.8	1.1	-0.7	-1.0	-0.8
BMI	0.5	2.7	4.8	1.5	2.2	1.0
Relative age of first facial hair	0.5	1.0	1.7	-1.0	-1.3	-0.3
Allergy	0.5	1.1	1.9	1.2	-0.2	1.4
Noisy workplace	0.5	0.6	0.9	1.0	0.5	0.9
Medication for pain relief, constipation, heartburn	0.5	0.9	1.4	-0.7	-1.2	-0.9
Supplements: Vitamin C	0.5	0.6	0.9	0.6	0.7	1.0
Knee pain experienced in last month	0.5	0.8	1.7	1.3	0.7	0.6
Osteoarthritis (self-reported)	0.5	0.6	0.9	-1.0	-0.6	-0.6
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.0	-0.7	-1.0	-0.7
Medication: Lisinopril	0.5	0.7	1.1	-1.1	-0.1	-1.0
Medication: Atorvastatin	0.5	0.6	0.8	0.5	0.9	0.8
Number of operations (self-reported)	0.5	0.7	1.0	-1.0	-0.8	-0.6
Bipolar Disorder (2018)	0.4	0.7	1.2	-1.1	-0.7	-0.7
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.5	-1.2	-1.0	-0.9
Schizophrenia (2018)	0.4	0.9	1.1	-0.8	-1.1	-1.0
Pack years adult smoking proportion	0.4	0.6	1.3	0.6	1.1	0.3
Taking other prescription medications	0.4	0.5	0.9	-0.9	0.2	-0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.6	-0.7	-0.8	-0.7
Hair/balding pattern: Pattern 3	0.4	0.6	1.4	-0.1	-0.6	-1.2
Pulse rate	0.4	0.7	1.0	0.6	0.9	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	-0.6	-1.1	-0.2
Lung cancer (father)	0.4	0.4	1.1	-0.4	-1.0	-0.1
Blood clot in the leg (DVT)	0.4	0.6	1.1	-1.0	-0.1	-0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	0.7	-0.7	-0.9	-0.8
Exposure to tobacco smoke outside home	0.4	0.6	1.4	-0.4	-1.2	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.0	-0.2	-1.0	-0.7
Loneliness, isolation	0.4	0.5	1.2	-0.4	-1.1	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.0	-0.1	-0.4	-1.0
Ever smoked	0.4	0.7	1.3	-1.2	-0.7	-0.5
Age started oral contraceptive pill	0.4	0.6	1.1	-0.4	-1.0	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.1	0.6	1.1	0.4
Worry (Nagel 2018)	0.3	0.5	1.0	-0.8	-1.0	-0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.0	-1.0	-0.8	-0.9
Heel T-Score	0.3	2.5	5.4	1.1	2.3	0.9
Diabetes (father)	0.3	0.4	0.8	0.1	0.9	0.6
Number of incorrect matches in round	0.3	0.4	0.8	-0.9	-0.6	-0.3
Hair/balding pattern: Pattern 2	0.3	0.4	0.4	0.6	0.5	0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.1	-0.2	1.0	0.1
Fluid intelligence score	0.3	0.5	0.8	-0.6	-0.9	-0.7
Illnesses of siblings	0.3	0.4	0.9	-0.5	-0.4	-0.9
Number of live births	0.3	0.4	0.8	-0.9	-0.3	-0.5
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.0	-0.7	-0.6	-1.0
Mouth/teeth dental problems: Dentures	0.3	0.5	0.8	-0.6	0.5	-0.9
Medication: Lansoprazole	0.3	0.4	0.9	0.5	0.9	0.3
Pulse wave Arterial Stiffness index	0.3	0.3	0.5	0.7	0.5	0.5
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.0	-0.1	-1.0	0.0
Body fat percentage	0.3	1.0	2.0	0.8	1.4	0.6
Neck or shoulder pain in last month	0.3	0.4	0.8	-0.9	-0.5	-0.3
Medication: Ibuprofen	0.3	0.3	0.7	-0.5	-0.9	-0.2
Leg pain on walking	0.3	0.4	0.4	-0.5	-0.7	-0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.7	-0.4	0.8	0.5
Breast cancer (self-reported)	0.3	0.4	1.1	0.0	1.1	0.4
Miserableness	0.3	0.6	1.1	-0.5	-1.0	-0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	-0.7	-0.2	-0.8
Risk taking	0.3	0.5	0.6	0.6	0.8	0.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	-0.9	0.0	-0.6
Pack years of smoking	0.3	0.5	1.3	0.5	1.1	0.1
Ovarian Cancer	0.2	0.3	0.4	0.7	0.2	0.5
Coronary Artery Disease (CAD)	0.2	0.2	0.3	0.5	0.2	0.5
Crohns Disease (2012)	0.2	0.3	0.6	0.8	0.5	0.1
HDL Cholesterol	0.2	0.3	0.7	0.3	-0.1	0.8
Ulcerative Colitis	0.2	0.2	0.4	0.6	0.5	0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.8	-0.4	0.9	-0.1
Number of treatments/medications taken	0.2	0.3	0.8	-0.3	0.9	0.2
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.3	0.0	-0.5	0.6
Angina	0.2	0.3	0.5	-0.7	-0.2	-0.6
Medication: Co-codamol	0.2	0.2	0.5	0.2	0.7	-0.1
Medication: Metformin	0.2	0.2	0.6	-0.7	-0.1	-0.3
Maternal smoking around birth	0.2	0.3	1.0	-0.1	-1.0	0.0
Fed-up feelings	0.2	0.4	0.9	-0.3	-1.0	-0.4
Serious illness, injury or assault to yourself	0.2	0.3	0.5	-0.4	-0.7	-0.4
High blood pressure (mother)	0.2	0.2	0.3	-0.4	-0.5	-0.6
Arm fat percentage (right)	0.2	0.8	2.0	0.7	1.4	0.1
Depression (self-reported)	0.2	0.3	0.5	0.4	0.5	0.7
Gout (self-reported)	0.2	0.2	0.3	0.5	0.6	0.4
Medication: Allopurinol	0.2	0.3	0.6	0.5	0.2	0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.4	-0.4	0.7	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	0.4	0.7	0.0
Arm fat percentage (left)	0.2	0.9	2.0	0.8	1.4	0.2
Diabetes diagnosed by doctor	0.2	0.4	0.8	0.2	0.9	0.5
Eye problems/disorders: Cataract	0.2	0.2	0.4	-0.6	-0.4	-0.2
Medication for cholesterol	0.2	0.4	0.9	1.0	-0.3	0.1
Osteoporosis (self-reported)	0.2	0.2	0.6	-0.1	0.8	-0.1
Smoking status: Current	0.2	0.4	0.7	-0.5	-0.9	-0.1
Wears glasses or contact lenses	0.2	0.2	0.3	0.6	0.1	0.5
High cholesterol (Self-reported)	0.2	0.4	0.6	-0.8	-0.5	-0.5
Alzheimer’s Disease (in father)	0.1	0.2	0.3	0.2	-0.6	0.3
Lupus	0.1	0.1	0.2	-0.3	-0.2	-0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.5	0.1	-0.1
Allergy or Eczema	0.1	0.3	0.7	0.3	0.9	-0.1
Tanning	0.1	0.8	1.2	0.5	1.1	0.9
Ever had hysterectomy (womb removed)	0.1	0.2	0.3	0.3	0.5	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.4	-0.5	-0.3	-0.7
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.8	0.3	0.9	-0.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.6	0.2	-0.0
Diabetes (self-reported)	0.1	0.1	0.3	-0.3	0.5	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.5	0.0	-0.0
Medication: Cholesterol lowering	0.1	0.1	0.3	0.0	0.5	0.1
Pulse wave reflection index	0.1	0.1	0.2	0.4	-0.1	0.1
Loud music exposure frequency	0.1	0.2	0.4	0.0	0.1	0.7
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.4	0.2	0.0
Glaucoma (self-reported)	0.1	0.1	0.3	-0.0	0.3	0.6
Leg fat percentage (right)	0.1	0.3	0.9	0.3	1.0	0.0
Comparative body size at age 10	0.1	0.3	0.7	-0.1	0.3	0.8
Emphysema/chronic bronchitis	0.1	0.1	0.3	-0.1	0.4	0.5
Angina (self-reported)	0.1	0.1	0.2	-0.5	-0.1	-0.3
Medication: Omeprazole	0.1	0.2	0.4	0.3	0.6	0.2
Pulse rate, automated reading	0.1	0.3	0.7	-0.2	0.8	0.2
Suffer from ‘nerves’	0.1	0.2	0.3	0.6	-0.0	0.5
Average weekly red wine intake	0.1	0.2	0.3	-0.3	-0.5	-0.3
Commuting to job workplace: Walk	0.1	0.1	0.1	0.2	-0.1	0.4
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	0.4	-0.1	0.2
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.5	-0.4	-0.2
Financial situation satisfaction	0.1	0.2	0.5	-0.1	-0.7	-0.2
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.4	-0.2	-0.2
Leg fat percentage (left)	0.1	0.4	1.1	0.3	1.0	0.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	0.5	-0.1	0.4
Cholesterol lowering medication	0.1	0.2	0.6	-0.8	-0.1	-0.2
Pain experienced in last month	0.1	0.1	0.2	0.4	0.3	0.3
Supplements: Calcium	0.1	0.1	0.3	-0.4	-0.5	-0.2
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.2	0.0	0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.1	0.2	-0.2	-0.4	0.5
Average weekly spirits intake	0.0	0.0	0.0	-0.1	0.0	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.1	-0.1	-0.4	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.1	-0.1	0.2	-0.2
Exposure to tobacco smoke at home	0.0	0.0	0.1	0.0	-0.3	0.0
Headache pain in last month	0.0	0.0	0.1	-0.0	0.3	0.1
Number of full brothers	0.0	0.0	0.1	-0.1	-0.3	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.2	-0.3	0.0
Pulse wave peak to peak time	0.0	0.0	0.0	-0.2	0.1	0.2
Migraine (self-reported)	0.0	0.1	0.1	-0.1	0.2	0.3
Overall health rating	0.0	0.1	0.1	-0.1	-0.3	-0.3
Medication: Aspirin	0.0	0.0	0.1	-0.2	0.3	0.1
Medication: Aspirin	0.0	0.1	0.1	-0.1	0.3	0.2
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	-0.2	-0.2	0.2

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