Hub : Genes

PPIL6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0830	0.0360	2.1e-04	0.017	0.039	0.025	0.040	0.021	2.9e-03	1.4e-05	4.8e-04	1.2e-05	1.1e-03
2	GTEx	Brain Cerebellum	0.3020	0.0930	2.2e-03	0.144	NA	0.020	NA	0.112	4.8e-05	NA	8.2e-02	NA	3.5e-04
3	GTEx	Brain Cortex	0.2890	0.1070	7.0e-03	0.220	NA	0.140	NA	0.179	9.9e-07	NA	1.1e-04	NA	1.1e-05
4	GTEx	Cells Transformed fibroblasts	0.0650	0.0350	7.7e-03	-0.001	NA	-0.002	NA	-0.003	3.9e-01	NA	4.6e-01	NA	7.3e-01
5	GTEx	Thyroid	0.1690	0.0490	4.5e-07	0.054	NA	0.101	NA	0.115	5.4e-05	NA	3.9e-08	NA	4.4e-09
6	NTR	Blood	0.0217	0.0105	5.6e-04	0.007	0.007	0.006	0.006	0.007	1.6e-03	2.0e-03	2.9e-03	3.0e-03	2.1e-03
7	TCGA	Breast Invasive Carcinoma	0.0529	0.0204	1.5e-10	0.039	0.056	0.059	NA	0.054	1.3e-08	1.3e-11	3.9e-12	NA	2.7e-11
8	TCGA	Brain Lower Grade Glioma	0.0527	0.0289	6.0e-04	0.035	0.021	0.015	NA	0.020	6.6e-05	1.8e-03	7.0e-03	NA	2.0e-03
9	TCGA	Liver Hepatocellular Carcinoma	0.0750	0.0560	8.8e-03	0.028	0.016	0.011	NA	0.013	1.8e-02	5.8e-02	9.4e-02	NA	7.7e-02
10	TCGA	Thyroid Carcinoma	0.0950	0.0390	7.1e-07	0.085	0.072	0.076	NA	0.073	1.1e-08	1.4e-07	7.7e-08	NA	1.4e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.4	0.6	1.8	0.3	-0.3	-0.5	-0.4	-1.0	1.4	-0.9	-0.3	-0.7	-1.0
Bipolar Disorder or Schizophrenia	0.3	0.8	2.4	1.3	1.4	1.0	0.5	-0.5	0.7	0.1	0.1	-1.5	-0.0
Depressed Affect (Nagel 2018)	1.2	2.4	4.9	1.7	-1.2	-1.2	-2.0	-1.4	2.2	-1.8	-1.1	-1.0	-1.5
Depression (Nagel 2018)	0.8	1.2	2.2	1.5	-0.2	-0.6	-1.2	-1.3	1.4	-1.1	-0.8	-1.3	-0.8
Intelligence (Savage-Jansen 2018)	0.2	0.5	2.0	0.5	-0.1	0.2	-1.1	-0.8	0.5	-0.6	0.0	-1.4	0.2
Neuroticism (Nagel 2018)	1.2	2.8	5.6	1.7	-1.0	-1.1	-1.9	-1.8	2.4	-2.0	-1.0	-1.7	-1.6
Schizophrenia (2018)	0.6	1.3	4.0	1.4	2.0	1.6	1.0	0.1	-0.2	0.8	0.4	-1.4	0.8
Schizophrenia vs Biploar Disorder	0.7	0.9	3.4	-1.2	-0.0	0.1	1.0	0.5	-1.8	0.7	-0.3	1.3	0.4
Worry (Nagel 2018)	0.5	1.0	3.3	0.1	-1.8	-1.0	-0.7	-0.7	0.8	-1.2	-0.5	-0.3	-1.3
Alzheimer’s Disease (in mother)	0.6	0.7	1.3	0.8	-0.3	-0.2	-1.2	-0.9	1.1	-0.2	-1.0	-1.0	-0.6
Alzheimer’s Disease (in father)	0.8	0.8	1.7	0.8	1.3	1.2	0.3	0.9	-0.3	1.0	1.2	0.1	1.1
Alzheimer’s Disease (including proxy)	0.8	1.1	4.1	2.0	1.0	1.0	-0.7	-0.4	1.3	0.4	-0.0	-1.6	0.2
Crohns Disease (2017)	0.8	1.8	4.8	-2.2	-1.0	-1.4	-0.2	-0.3	-1.4	-0.7	-1.6	1.6	-1.6
Irritable Bowel Disease (IBD)	0.5	1.3	5.0	-1.7	0.6	-0.3	1.1	0.6	-2.2	0.6	-0.4	1.6	-0.3
Ulcerative Colitis (UC)	0.7	1.3	3.3	-0.6	1.3	0.5	1.4	1.1	-1.8	1.3	0.7	1.1	0.7
Major Depression (MDD)	2.0	2.4	5.3	1.7	0.1	-0.7	-1.3	-1.7	1.9	-1.9	-1.4	-2.3	-1.4
Reaction Time	1.3	2.4	4.0	1.0	-0.6	-0.9	-1.8	-1.9	2.0	-1.5	-1.5	-2.0	-1.5
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.1	0.5	-0.3	-1.0	-1.2	-1.4	0.9	-1.3	-0.7	-1.1	-0.9
Breast Cancer	0.7	1.7	3.8	-0.3	-0.7	-1.0	-1.4	-1.9	0.9	-1.4	-1.9	-1.6	-1.0
Ovarian Cancer	0.8	1.1	2.5	1.1	0.2	1.6	0.8	1.1	0.3	0.5	1.6	-0.0	1.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.9	2.7	5.1	1.7	0.3	-0.9	-2.1	-2.1	2.2	-1.7	-0.8	-2.1	-1.1
Bipolar Disorder (2011)	2.4	2.3	7.8	1.9	1.0	0.6	-0.9	-1.3	2.5	-1.2	-0.5	-2.8	-0.7
Body Mass Index (BMI) (2010)	2.0	2.8	9.6	-2.3	-2.6	-1.5	1.1	0.7	-1.1	0.3	-1.0	3.1	-0.8
Coronary Artery Disease (CAD)	0.9	1.1	2.5	0.6	1.0	1.4	1.4	1.1	0.1	0.9	1.6	0.1	1.2
Crohns Disease (2012)	1.4	2.3	5.2	-2.3	-1.5	-2.0	-0.7	-1.2	0.2	-1.5	-1.8	1.0	-1.9
Mean Putamen Volume	1.0	1.1	3.1	0.9	-1.1	-0.5	-1.1	-1.0	1.8	-1.3	-0.5	-1.1	-0.8
Fasting Glucose	0.6	0.7	2.2	-1.5	-1.0	-0.7	0.9	-0.1	-1.0	-0.3	-0.8	1.1	0.1
HbA1C	2.5	2.7	6.9	-1.6	-2.4	-2.6	-0.3	-1.3	-0.5	-1.4	-2.3	1.3	-1.2
HDL Cholesterol	1.0	1.6	3.1	0.5	1.8	1.0	1.2	1.4	-1.3	1.4	1.5	0.7	1.2
LDL Cholesterol	3.0	4.8	11.5	3.4	0.7	-0.9	-1.7	-2.3	2.6	-2.4	-1.9	-2.8	-1.7
Lupus	0.1	0.1	0.7	-0.2	0.9	-0.1	-0.2	-0.4	0.3	-0.2	-0.1	-0.3	-0.2
Neuroticism (2016)	1.4	2.0	6.1	-0.2	-1.1	-1.3	-1.3	-1.7	2.5	-1.9	-0.9	-0.9	-1.1
Primary Biliary Cirrhosis	0.7	1.0	4.3	1.6	1.2	0.9	-0.6	-0.6	0.3	-0.5	-0.5	-2.1	0.1
Rheumatoid Arthritis	2.1	2.9	7.1	-1.3	1.3	1.3	1.3	2.0	-2.7	2.0	1.6	1.8	1.2
Schizophrenia (2014)	0.3	0.7	2.7	0.7	1.4	0.8	0.3	-0.9	0.7	-0.2	-0.5	-1.6	-0.2
Triglycerides	0.7	1.2	2.7	0.7	-0.0	-0.2	-0.8	-1.5	0.8	-1.5	-1.4	-1.6	-1.0
Type 2 Diabetes (T2D) (2012)	3.1	3.5	6.7	-1.4	-2.6	-2.6	-1.0	-1.9	1.2	-2.1	-2.0	0.6	-2.3
Ulcerative Colitis	0.1	0.1	0.5	-0.3	0.6	-0.5	0.7	-0.1	-0.1	-0.0	-0.0	0.4	-0.2
Blood Eosinophil Count	1.7	13.1	41.5	4.6	3.5	0.5	-3.0	-4.1	4.0	-3.3	-1.4	-6.4	-1.4
Blood Platelet Count	1.2	14.2	37.2	1.5	1.1	-1.5	-2.7	-5.3	5.0	-4.5	-2.7	-6.1	-3.2
Blood Red Count	2.8	26.8	87.4	-1.8	-9.3	-7.0	-4.5	-2.5	-2.0	-3.0	-6.7	4.1	-5.1
Blood White Count	0.5	3.7	18.0	1.7	2.6	1.8	0.3	-1.5	1.4	-1.1	0.5	-4.2	0.2
Heel T-Score	0.1	0.7	3.2	1.8	-1.1	-0.4	-0.8	0.6	-0.5	-0.0	-0.4	0.7	-0.1
BMI	0.4	2.5	7.4	-0.0	-2.7	-2.6	-1.0	-0.9	-0.2	-1.6	-1.3	1.0	-2.0
Height	4.7	90.2	219.0	-10.7	-2.5	2.8	10.9	12.0	-9.1	8.9	8.6	14.8	7.4
Waist Hip Ratio (WHR)	0.4	1.8	7.4	2.7	1.1	0.3	-0.1	-0.5	2.5	-0.8	0.0	-1.5	-0.3
Systolic Blood Pressure	0.4	1.9	6.1	-1.1	-1.1	-0.6	1.7	0.9	-2.5	0.6	-1.0	2.1	-0.5
Smoking Status	0.3	0.7	3.9	0.5	0.9	0.7	-0.5	-0.7	0.5	-0.4	-0.2	-2.0	-0.4
Allergy or Eczema	0.1	0.4	0.8	-0.3	0.1	-0.9	-0.5	-0.7	-0.9	-0.6	-0.5	0.5	-0.8
Cardiovascular Disease	0.7	2.2	6.8	-0.8	0.0	0.6	2.6	1.8	-1.9	1.2	1.0	1.8	1.3
Hypothyroidism (self reported)	2.1	4.8	9.5	1.0	-1.8	-1.7	-2.2	-2.4	2.3	-2.5	-3.1	-1.9	-2.5
Respiratory disease	2.4	5.2	10.2	2.4	0.6	-1.0	-2.9	-2.8	2.1	-2.3	-2.2	-3.2	-2.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	1.4	0.3	0.2	0.1	1.2	0.4	-0.2	0.1	-0.0	0.1	0.2
Lung FEV1/FVC ratio	0.7	3.4	8.6	-1.3	-2.2	0.6	2.2	2.5	-1.4	1.6	1.0	2.9	1.0
Lung FVC	1.5	7.6	24.5	-2.0	-0.3	0.5	2.4	3.8	-3.0	2.9	2.6	4.9	1.4
Neuroticism	0.6	1.6	6.4	1.6	-0.1	-0.1	-0.9	-1.0	2.5	-1.5	-0.3	-1.3	-0.7
Chronotype (morning person)	1.3	3.0	9.4	-2.8	-2.4	-1.6	-0.0	0.6	-1.8	0.1	-0.8	3.1	-0.3
Hair Pigment	0.1	3.3	7.5	2.5	2.1	2.7	1.6	1.4	0.8	1.2	2.1	-0.1	2.0
Tanning	0.1	0.6	1.1	-0.9	-0.1	0.4	0.8	0.9	-1.0	0.9	1.1	0.6	0.7
Hand grip strength (left)	1.1	2.9	6.2	-0.0	0.7	1.5	1.6	2.5	-0.6	1.9	2.5	1.7	2.0
Number of treatments/medications taken	0.7	1.3	2.9	1.1	1.3	1.7	1.4	1.1	-0.2	0.8	1.2	-0.3	1.3
Average weekly spirits intake	0.1	0.1	0.3	0.5	-0.3	-0.0	-0.1	-0.0	0.5	0.2	0.2	-0.1	0.5
Sensitivity / hurt feelings	1.9	3.2	10.4	2.2	-0.1	-0.7	-1.1	-2.0	3.2	-1.9	-0.9	-2.5	-1.1
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.7	0.7	-0.2	-0.5	-1.3	-0.9	0.8	-1.0	-0.7	-1.0	-0.5
Hearing difficulty/problems: Yes	2.2	3.4	5.8	0.8	-1.6	-1.8	-1.3	-2.2	2.2	-2.4	-2.2	-1.6	-1.6
Relative age of first facial hair	0.9	1.9	4.0	1.6	1.7	1.6	0.5	0.9	0.7	1.0	2.0	-1.0	1.8
Other serious medical condition/disability diagnosed by doctor	1.0	1.4	5.4	1.8	0.6	0.9	-1.0	-1.0	1.1	-0.7	-0.2	-2.3	0.3
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.8	-0.1	0.4	0.7	0.4	0.8	0.4	0.8	1.4	0.6	1.2
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	-0.4	0.6	0.3	-0.0	0.4	-0.5	0.5	0.4	0.6	0.6
Systolic blood pressure, automated reading	0.7	2.2	6.9	-1.3	-1.7	-1.3	0.8	0.3	-2.6	-0.0	-1.5	2.2	-0.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.9	-0.2	-0.8	0.1	-0.3	0.6	-0.2	0.0	0.2	0.9	-0.1
Angina	0.2	0.2	0.6	0.2	0.7	-0.1	-0.0	-0.6	-0.8	-0.3	-0.3	-0.7	0.0
Medication for hormone replacement therapy	1.0	1.1	3.0	0.9	1.3	0.2	-0.8	-1.2	1.6	-0.8	-0.2	-1.7	-0.3
Vitamin and mineral supplements	1.3	1.7	2.7	-0.3	0.7	1.2	1.5	1.6	-1.4	1.6	1.4	1.1	1.6
Supplements: Zinc	0.5	0.6	2.0	1.0	1.4	0.6	-0.2	-0.4	0.8	0.0	0.1	-1.2	0.2
Medication: Co-codamol	0.2	0.2	1.3	-0.4	0.2	-0.5	-0.0	-0.4	-1.1	0.0	-0.3	-0.1	0.2
Medication: Metformin	0.1	0.1	0.5	0.3	0.7	0.4	-0.0	-0.0	0.1	-0.1	-0.0	-0.6	-0.3
Diabetes (father)	1.1	1.4	2.7	0.1	1.6	1.4	0.9	1.1	-1.2	1.4	1.1	-0.1	1.4
Diabetes (mother)	2.1	2.7	9.3	-3.1	-1.9	-0.9	1.3	0.9	-2.1	0.5	-0.2	2.5	-0.1
Severe depression (siblings)	1.6	1.8	5.0	2.2	1.6	1.7	0.0	0.5	1.0	0.9	1.0	-1.7	1.1
Pack years adult smoking proportion	1.0	1.5	5.2	-1.1	-2.3	-1.5	0.2	-0.2	-0.1	-0.7	-1.3	1.2	-1.4
Impedance of leg (right)	2.2	10.4	19.3	2.3	-0.5	-1.6	-3.7	-4.2	3.2	-3.6	-3.4	-4.4	-3.2
Leg fat-free mass (left)	4.7	24.9	67.6	-4.7	-0.8	0.9	5.5	6.4	-5.2	4.8	4.7	8.2	3.9
Trunk fat percentage	0.6	2.3	7.5	-0.2	-2.7	-2.5	-0.8	-0.7	-0.6	-1.3	-1.3	1.2	-1.7
Hand grip strength (right)	2.4	6.4	13.0	-0.8	0.9	1.6	2.8	3.6	-1.3	2.8	3.5	3.2	2.7
Townsend deprivation index at recruitment	0.8	1.2	4.3	-1.8	-0.9	-1.0	0.1	0.6	-0.9	-0.1	-0.6	2.1	-0.8
Current tobacco smoking	0.4	0.7	1.8	-0.5	-1.1	-0.7	-0.8	-0.6	0.9	-0.9	-0.8	-0.2	-1.3
Average weekly fortified wine intake	3.5	4.1	8.8	3.0	-0.1	-1.5	-1.2	-2.2	2.9	-2.4	-1.3	-2.3	-1.7
Maternal smoking around birth	0.4	0.5	2.6	1.6	0.6	0.1	0.5	-0.1	1.3	0.0	0.2	-0.1	0.3
Fed-up feelings	0.3	0.6	2.1	0.4	-0.7	-0.2	-1.2	-0.3	1.5	-1.0	-0.0	-0.1	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	0.7	0.6	0.9	-0.6	0.3	0.2	0.8	0.5	-0.4	0.8
Relative age voice broke	1.1	1.6	4.8	2.2	1.3	1.3	0.2	0.3	1.4	0.2	1.4	-1.6	1.0
Taking other prescription medications	0.3	0.4	1.8	1.3	-0.5	0.2	-0.4	-0.3	0.9	-0.7	-0.1	-0.7	-0.1
Age when periods started (menarche)	2.1	5.0	13.0	-2.6	-1.4	0.7	2.0	2.9	-1.6	2.3	2.3	3.6	1.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.9	-0.1	0.9	0.8	0.5	0.5	-1.4	0.8	0.3	0.5	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	8.0	2.8	0.1	0.2	-1.5	-0.5	1.3	-0.3	-0.1	-1.1	-0.3
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	6.1	2.4	-0.9	-0.9	-1.7	-1.6	2.5	-2.0	-0.8	-2.0	-1.4
Qualifications: CSEs or equivalent	0.7	0.9	3.9	-1.4	-0.8	-0.9	0.8	0.5	-0.7	0.6	-0.2	2.0	-0.1
Serious illness, injury or assault to yourself	0.2	0.2	0.8	0.9	0.6	0.0	-0.4	-0.3	0.0	0.1	-0.3	-0.5	-0.4
High blood pressure	0.6	1.8	6.1	-0.6	-0.4	0.5	2.5	1.6	-1.6	1.1	0.5	1.6	1.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.2	-0.3	-0.5	-1.1	-0.8	-1.0	-0.8	-0.9	-0.9	0.4	-1.1
Multivitamins +/- minerals	1.4	1.8	3.5	0.2	-0.7	-1.4	-1.6	-1.5	1.9	-1.8	-1.1	-0.6	-1.6
Stomach or abdominal pain in last month	0.3	0.3	1.2	0.4	-0.1	-0.2	-1.1	-0.6	0.1	-0.6	-0.6	-0.7	-0.5
Supplements: Glucosamine	1.8	2.3	7.7	2.8	1.1	0.3	-0.9	-1.5	2.0	-0.5	-0.6	-2.5	-0.2
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.3	0.7	0.5	-0.4	-1.1	-0.8	0.6	-1.1	-0.6	-0.6	-0.8
Medication: Atenolol	1.4	1.7	5.8	-1.3	0.2	0.1	1.5	1.3	-2.4	1.3	0.6	1.8	1.0
Medication: Levothyroxine sodium	2.7	4.5	7.8	0.4	-2.8	-2.1	-2.0	-2.1	2.2	-2.5	-2.7	-0.5	-2.5
Sitting height	9.8	69.5	125.4	-7.0	2.0	4.8	9.7	10.7	-8.1	9.0	8.7	11.2	8.0
Chronic bronchitis/emphysema (father)	0.2	0.3	1.3	-0.4	0.3	0.7	-1.1	0.3	0.4	0.3	0.4	-0.2	0.3
High blood pressure (mother)	2.3	3.2	5.7	-1.7	-1.6	-2.2	-2.1	-1.7	0.4	-1.9	-2.2	0.3	-2.4
Body mass index (BMI)	0.3	1.3	4.8	-0.7	-2.0	-1.6	0.2	0.6	-0.9	-0.1	0.2	2.2	-0.4
Impedance of leg (left)	1.9	9.4	23.3	2.9	0.3	-0.9	-3.3	-3.8	3.1	-3.2	-3.0	-4.8	-2.7
Leg predicted mass (left)	4.7	24.7	65.4	-4.5	-0.7	1.0	5.5	6.4	-5.2	4.8	4.7	8.1	4.0
Trunk fat mass	0.7	3.0	11.2	-1.5	-2.4	-1.6	1.1	1.4	-2.0	0.5	0.5	3.4	-0.1
Waist circumference	0.5	1.9	8.5	-1.0	-1.8	-1.3	1.3	1.3	-1.0	0.5	0.6	2.9	0.0
Number of incorrect matches in round	1.0	1.6	3.0	1.7	1.6	1.6	0.4	0.9	0.9	1.2	1.6	-0.8	1.3
Past tobacco smoking	1.1	2.0	6.8	-2.0	-2.6	-1.7	-0.3	0.2	-0.6	-0.2	-0.3	2.2	-0.9
Alcohol usually taken with meals	1.3	2.0	5.6	1.1	-0.5	-0.6	-1.2	-2.0	1.2	-1.6	-1.5	-2.4	-1.1
Nervous feelings	0.6	1.1	2.8	-0.2	-1.4	-1.0	-1.3	-0.9	0.4	-1.1	-1.2	-0.5	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.5	1.5	0.4	0.7	-1.5	-0.7	1.3	-0.7	-0.1	-1.9	-0.1
Hearing difficulty/problems with background noise	1.4	2.2	4.4	0.7	0.0	-1.1	-2.0	-2.0	1.3	-1.7	-1.5	-2.1	-0.9
Hair/balding pattern: Pattern 2	0.5	0.6	2.5	-0.5	-1.6	-0.7	-0.2	-0.1	-0.1	-0.7	-0.8	1.0	-0.7
Had menopause	1.8	2.2	4.4	0.2	0.4	1.5	1.6	2.1	-1.4	2.0	1.5	1.5	1.7
Had other major operations	1.7	2.0	5.8	1.3	0.1	-0.2	-1.9	-1.9	0.4	-1.5	-1.6	-2.4	-1.0
Forced vital capacity (FVC)	4.9	18.9	55.2	-5.1	-0.6	0.7	4.0	5.4	-4.9	4.2	3.7	7.4	2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	6.1	2.5	0.3	0.5	-1.1	-0.0	1.0	0.1	0.3	-0.7	0.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.1	0.7	1.1	0.9	-0.0	0.3	0.7	0.7	0.4	-0.5	0.3
Qualifications: None of the above	0.8	1.8	5.2	-1.3	-0.3	0.9	0.7	1.8	-1.6	1.5	0.7	2.3	0.9
Financial difficulties in last 2 years	0.2	0.3	0.9	-0.9	-0.0	-0.5	-0.2	0.4	-0.6	-0.0	0.1	0.9	-0.1
Mouth/teeth dental problems	0.8	1.2	5.8	-2.4	-1.0	-0.5	0.3	0.7	-0.9	0.2	0.2	1.9	-0.2
Heart attack	0.7	0.9	2.5	1.5	0.8	1.1	-0.2	-0.5	1.1	-0.4	0.3	-1.6	0.3
Allergy	0.4	1.0	2.5	-0.5	-0.2	0.8	1.6	1.4	-0.2	0.9	1.1	0.9	1.2
Pain all over the body in last month	2.1	2.3	4.7	-0.3	1.4	1.4	2.2	1.5	-1.6	1.8	1.6	0.6	1.8
Diabetes (self-reported)	0.2	0.3	1.1	0.7	0.6	0.6	1.1	0.5	-0.1	0.5	0.3	-0.3	0.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.1	0.8	-0.1	-1.5	0.7	-0.7	0.4	-1.1	-0.3	0.4	-0.7
Medication: Ramipril	0.5	0.7	3.5	-0.6	0.8	0.5	0.6	0.8	-1.9	0.6	-0.0	0.6	0.3
Medication: Simvastatin	1.4	2.0	8.7	3.0	0.8	-0.4	0.1	-1.4	1.4	-1.3	-0.5	-2.1	-0.5
Fluid intelligence score	0.2	0.4	1.1	0.5	0.1	-0.0	-1.0	-0.7	1.0	-0.5	-0.1	-1.0	-0.4
Illnesses of siblings	0.8	1.1	2.0	-0.5	-1.3	-0.8	-1.4	-1.0	0.4	-1.1	-1.2	-0.5	-1.4
Neuroticism score	1.4	3.0	7.9	1.6	-0.8	-1.0	-1.8	-1.8	2.8	-2.3	-1.0	-1.7	-1.4
Weight	2.5	12.3	38.9	-3.3	-1.6	-0.1	3.7	4.4	-3.8	2.9	3.1	6.2	2.2
Impedance of arm (right)	1.3	6.3	11.3	1.2	-0.7	-1.3	-3.1	-3.4	1.7	-2.6	-3.3	-3.2	-2.7
Arm fat percentage (right)	1.0	3.9	8.3	0.0	-2.9	-2.9	-2.1	-1.7	0.1	-2.2	-2.0	0.2	-2.5
Trunk fat-free mass	5.5	31.8	71.9	-5.0	0.2	2.1	6.3	7.4	-5.5	5.7	5.8	8.5	5.0
Hip circumference	1.3	5.8	20.2	-3.2	-2.3	-1.2	2.0	2.2	-3.0	1.3	0.9	4.5	0.5
Time employed in main current job	0.9	1.0	3.3	-1.6	-1.2	-0.3	0.7	0.6	-1.8	-0.0	-0.3	1.3	-0.4
Alcohol intake versus 10 years previously	1.1	1.6	4.7	-0.4	-0.5	0.4	1.3	1.8	-1.1	1.4	1.4	2.2	1.1
Father’s age at death	0.4	0.6	1.2	-0.4	-1.1	-0.8	0.0	-1.1	0.6	-0.3	-1.0	-0.9	-0.5
Worrier / anxious feelings	0.8	1.4	3.1	0.1	-1.3	-1.4	-0.8	-1.4	1.6	-1.7	-1.0	-0.4	-1.2
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.0	1.0	-0.1	-0.8	-0.6	-2.0	1.2	-1.6	-1.8	-1.9	-1.3
Falls in the last year	0.3	0.4	1.3	0.3	0.5	0.3	-1.1	-0.6	0.5	-0.5	-0.3	-1.1	-0.5
Hair/balding pattern: Pattern 3	1.7	2.5	4.2	-1.7	-1.5	-2.0	-1.6	-2.0	0.6	-1.5	-2.0	-0.2	-1.7
Number of live births	0.3	0.4	1.7	1.3	-0.3	-0.5	-0.7	-0.5	0.2	-0.7	-0.3	-0.7	-0.4
Forced expiratory volume in 1-second (FEV1)	5.5	18.4	55.8	-5.0	-1.1	0.6	3.8	5.4	-4.8	4.1	3.5	7.5	2.4
Pulse rate	0.6	1.1	2.2	-1.5	0.4	0.7	1.1	1.2	-1.2	1.3	0.2	0.9	0.9
Happiness	2.9	3.5	10.4	3.2	0.1	-0.4	-1.5	-1.8	3.1	-1.7	-0.2	-2.5	-0.4
Noisy workplace	0.4	0.4	1.9	-1.4	-0.8	0.0	-0.1	0.7	0.2	0.2	-0.0	1.2	-0.0
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.2	-0.8	-0.1	-0.5	-1.1	-1.0	0.0	-0.7	-1.0	-0.9	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.2	-0.6	-1.1	-1.0	-0.7	-0.6	0.4	-0.6	-0.8	0.6	-0.9
Mouth/teeth dental problems: Dentures	0.5	0.8	2.3	1.0	-1.5	-0.7	-0.8	-0.9	0.8	-0.5	-1.0	-0.4	-0.5
Asthma	1.0	2.1	4.1	2.0	1.0	-0.4	-1.7	-1.6	1.3	-1.2	-1.3	-2.0	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.5	1.6	0.8	1.2	0.0	0.8	1.3	0.3	1.2	-0.3	0.8
Medication: Cholesterol lowering	0.7	1.1	4.0	0.6	1.8	0.7	2.0	0.1	-1.4	0.3	0.5	-0.5	0.7
Depression (self-reported)	0.4	0.5	1.3	-0.2	0.5	0.6	0.3	1.0	0.5	0.8	1.1	0.6	1.0
Medication: Lansoprazole	0.3	0.3	1.0	1.0	-0.3	0.7	1.0	0.5	-0.4	0.4	-0.0	0.1	0.4
Prospective memory result	0.7	0.8	2.8	-1.1	-0.9	-0.4	0.9	0.6	-1.7	0.5	-0.0	1.3	0.4
Lung cancer (father)	0.2	0.3	0.8	0.9	-0.2	0.6	-0.2	0.2	0.8	0.2	0.7	-0.3	0.4
Illnesses of mother	0.4	0.5	0.9	-0.2	0.2	0.3	0.6	0.8	-0.7	0.9	0.7	0.9	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	5.0	16.0	47.5	-4.6	-0.9	0.8	3.4	5.0	-4.5	3.9	3.5	6.9	2.4
Pulse wave Arterial Stiffness index	0.7	0.8	2.7	-1.7	-1.3	-0.8	-0.1	0.2	-0.4	-0.2	-0.9	1.4	-0.3
Impedance of arm (left)	1.6	7.6	14.0	1.4	-0.9	-1.6	-3.1	-3.7	2.0	-2.8	-3.6	-3.5	-3.0
Arm fat mass (right)	0.7	2.9	9.9	-1.8	-2.6	-2.2	0.3	0.8	-1.8	-0.2	-0.1	3.1	-0.8
Trunk predicted mass	5.5	31.5	70.6	-4.9	0.2	2.2	6.3	7.4	-5.5	5.7	5.8	8.4	5.0
Standing height	4.8	48.0	95.8	-6.4	0.7	3.4	8.2	9.0	-7.0	7.3	6.7	9.8	6.1
Length of working week for main job	2.8	3.1	9.3	-2.2	1.3	1.5	0.7	1.9	-3.0	1.8	1.3	1.4	1.4
Exposure to tobacco smoke at home	1.4	1.6	4.8	1.2	1.0	2.2	0.5	1.2	-0.4	1.5	1.2	-0.6	1.6
Breastfed as a baby	7.6	9.4	17.0	-0.2	3.0	3.8	2.9	3.5	-1.6	4.0	3.6	1.0	4.1
Tense / ‘highly strung’	1.0	1.7	3.7	1.8	-1.2	-0.3	-1.3	-1.0	1.8	-1.3	-0.4	-1.9	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	3.9	1.3	0.1	0.0	-0.9	-0.5	2.0	-0.4	0.1	-1.2	0.0
Hair/balding pattern: Pattern 4	0.6	1.5	5.2	2.3	1.6	1.7	0.1	0.4	0.5	0.5	0.8	-1.6	0.9
Birth weight of first child	0.7	1.2	3.2	-0.6	-0.8	0.2	1.8	1.3	0.9	0.8	1.2	1.8	0.6
Peak expiratory flow (PEF)	5.3	12.4	31.3	-4.0	-0.5	1.1	3.3	4.4	-4.4	3.4	3.0	5.6	2.4
Pulse wave reflection index	0.6	0.8	1.8	-0.5	-1.3	-1.2	-0.8	-0.6	0.7	-1.1	-0.6	0.6	-1.0
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.2	0.5	0.6	0.3	-0.4	0.3	1.1	0.1	0.9	-0.1	0.5
Loud music exposure frequency	1.1	1.2	1.7	-1.0	1.3	1.2	1.3	0.9	-0.9	1.1	1.3	0.3	1.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	5.1	-0.9	-2.2	-1.6	0.1	-0.9	0.2	-1.2	-1.1	0.4	-1.1
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	5.5	2.0	2.3	1.2	0.3	-0.4	0.2	0.5	0.4	-2.2	1.1
Blood clot in the leg (DVT)	0.1	0.1	0.6	-0.1	0.6	0.3	-0.0	-0.3	0.1	-0.2	0.3	-0.8	0.1
Medication: Paracetamol	0.4	0.7	2.4	-0.5	-1.5	-1.0	-0.7	0.4	0.6	-0.3	0.5	1.4	-0.4
Headache pain in last month	0.2	0.4	2.0	0.2	1.4	0.8	0.2	0.6	-0.4	0.5	0.6	0.1	0.6
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	5.8	-0.1	-1.1	-0.9	-2.4	-0.9	1.3	-0.7	-0.9	-0.2	-1.3
Glaucoma (self-reported)	2.6	3.1	5.7	0.9	2.4	2.4	1.8	1.8	-1.2	2.1	1.7	-0.1	1.8
Gout (self-reported)	0.1	0.2	0.8	-0.2	0.9	-0.0	0.5	0.3	-0.5	-0.1	0.4	0.5	-0.3
Hypothyroidism/myxoedema (self-reported)	2.6	5.0	7.8	1.9	-2.4	-1.4	-2.2	-2.1	2.8	-2.4	-2.7	-1.8	-2.3
Medication: Amlodipine	0.9	1.3	4.0	-0.6	-0.3	0.6	2.0	1.3	-0.5	1.0	1.5	1.2	1.1
Medication: Ventolin 100micrograms inhaler	3.7	4.8	10.5	-0.4	-0.4	-2.7	-2.5	-3.1	1.1	-2.1	-3.2	-1.4	-2.5
Birth weight	6.1	13.2	24.2	-3.1	-0.5	2.8	4.8	4.9	-1.9	4.1	4.0	4.0	3.8
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.2	-0.4	1.0	1.4	0.9	1.5	-1.4	1.2	1.0	0.5	1.0
High blood pressure (siblings)	1.3	1.9	3.9	-1.1	0.5	0.9	2.0	1.7	-0.8	1.5	1.6	1.4	1.7
Forced vital capacity (FVC), Best measure	4.2	15.2	44.4	-4.7	-0.5	0.6	3.3	4.8	-4.5	3.7	3.5	6.7	2.2
Body fat percentage	0.6	2.4	6.8	0.4	-2.6	-2.4	-1.2	-1.1	-0.1	-1.6	-1.5	0.4	-1.9
Leg fat percentage (right)	0.8	2.8	6.3	0.8	-2.5	-2.4	-1.6	-1.5	0.7	-2.0	-1.6	-0.0	-1.9
Arm fat-free mass (right)	5.1	26.0	60.7	-4.2	-0.0	1.6	5.9	6.7	-5.2	5.0	5.3	7.8	4.4
Exposure to tobacco smoke outside home	0.1	0.1	0.6	0.6	-0.1	-0.1	-0.2	-0.3	0.4	-0.2	-0.8	-0.4	-0.0
Comparative body size at age 10	0.2	0.5	1.1	-0.3	0.7	0.6	-0.3	0.8	-0.2	1.1	1.1	0.4	0.7
Number of full brothers	0.7	0.9	2.6	-0.2	1.6	1.2	0.3	0.8	-0.6	1.1	1.0	-0.1	1.2
Worry too long after embarrassment	1.2	2.1	4.1	0.5	0.4	-0.7	-1.0	-2.0	1.7	-1.9	-1.4	-1.9	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	4.1	1.9	1.3	2.0	0.5	1.5	0.6	1.3	1.9	-0.7	2.0
Wheeze or whistling in the chest in last year	3.0	5.3	8.1	2.6	0.4	-1.2	-2.8	-2.6	2.6	-2.5	-2.0	-2.8	-2.2
Number of children fathered	4.0	4.6	9.5	0.7	1.6	2.1	1.8	2.6	-1.2	2.5	3.1	1.4	2.9
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.4	1.6	1.2	1.1	0.3	0.2	0.3	0.6	0.4	-0.9	1.3
Age at first live birth	1.6	2.9	10.2	1.9	1.2	-0.1	-0.9	-1.8	2.8	-1.3	0.0	-3.2	-0.2
Pulse wave peak to peak time	0.8	0.9	1.9	1.3	1.3	1.2	0.7	0.5	-0.1	0.8	1.4	-0.8	0.7
Health satisfaction	1.5	1.9	3.8	1.9	-0.3	-0.5	-1.5	-1.6	1.7	-1.4	-0.9	-1.9	-0.9
Shortness of breath walking on level ground	2.3	2.7	4.7	0.4	-1.4	-1.9	-2.0	-1.9	1.1	-1.6	-2.2	-0.7	-2.1
Qualifications: College or University degree	0.4	1.1	5.3	0.5	1.7	0.5	-0.6	-1.1	0.6	-0.8	-0.1	-2.3	0.1
Eye problems/disorders: None of the above	0.2	0.2	0.8	-0.6	0.2	0.2	-0.3	-0.4	0.3	-0.1	0.0	-0.9	0.7
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.9	1.1	0.3	-0.7	-0.7	-1.5	1.7	-1.1	-1.0	-1.4	-0.8
Emphysema/chronic bronchitis	0.8	0.9	1.8	0.7	0.8	0.9	1.3	1.0	0.1	1.0	1.3	0.2	1.1
Medication for pain relief, constipation, heartburn	0.2	0.4	0.9	-0.2	0.1	-0.5	-0.4	-0.9	-0.5	-0.5	-1.0	-0.8	-0.5
Neck or shoulder pain in last month	0.6	0.8	1.8	1.3	1.1	1.4	0.5	0.5	0.4	0.9	0.7	-0.9	1.0
Medication: Blood pressure	0.6	1.1	5.0	-0.2	0.1	0.6	2.2	1.1	-1.2	0.5	0.8	0.7	1.1
Angina (self-reported)	0.1	0.2	0.7	0.1	0.7	-0.0	0.2	-0.3	-0.9	-0.1	-0.0	-0.5	0.1
Migraine (self-reported)	0.6	0.7	1.8	0.6	0.8	1.1	0.6	0.9	-0.0	0.8	1.3	-0.0	1.0
Medication: Ibuprofen	0.7	0.9	2.6	1.6	0.8	1.2	-0.1	0.6	1.4	0.2	1.0	-0.5	0.7
Medication: Allopurinol	0.3	0.4	1.4	0.2	1.2	0.5	0.8	0.7	-0.3	0.2	1.0	0.6	0.1
Medication: Omeprazole	0.2	0.3	1.9	0.3	-1.4	-0.3	-0.2	-0.2	0.3	-0.2	-0.4	0.2	-0.1
Medication: Seretide 50 evohaler	0.4	0.4	1.7	-0.6	-0.2	-0.2	0.6	0.8	-0.5	0.2	0.8	1.3	0.3
Mean time to correctly identify matches	0.8	1.5	2.9	1.4	-0.3	-0.6	-1.3	-1.5	1.2	-1.0	-1.3	-1.7	-1.2
Heart disease (mother)	1.4	1.7	6.9	2.6	1.9	1.1	0.4	-0.2	1.1	0.1	0.6	-1.9	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	6.6	2.5	2.3	1.0	-0.8	-1.1	1.2	-0.2	-0.6	-2.6	0.2
Whole body fat mass	0.6	2.4	8.8	-1.2	-2.4	-1.6	0.9	1.2	-1.6	0.2	0.4	3.0	-0.3
Leg fat mass (right)	0.5	2.1	7.7	-0.9	-2.4	-1.7	0.7	1.0	-1.4	-0.0	0.4	2.8	-0.2
Arm predicted mass (right)	5.0	25.7	61.8	-4.3	-0.2	1.4	5.8	6.6	-5.2	5.0	5.2	7.9	4.3
Pulse rate, automated reading	0.1	0.2	0.8	-0.7	-0.6	0.1	-0.3	0.2	-0.9	0.3	-0.6	0.2	-0.2
Alcohol intake frequency.	2.9	6.7	13.6	-2.5	-0.0	1.1	1.8	3.5	-3.4	3.2	2.2	3.7	2.1
Comparative height size at age 10	3.0	16.5	30.7	-3.4	1.5	2.1	4.5	5.2	-4.9	4.5	3.4	5.5	3.7
Number of full sisters	1.1	1.4	2.8	-0.8	1.6	1.7	0.2	1.4	-0.2	1.4	1.4	0.9	1.1
Suffer from ‘nerves’	0.2	0.3	1.6	0.3	-1.3	-0.5	-0.1	0.4	-0.4	0.1	-0.2	0.6	-0.2
Overall health rating	0.0	0.1	0.4	0.6	-0.1	0.6	-0.1	0.1	0.3	0.2	-0.0	-0.3	0.0
Chest pain or discomfort	1.3	1.9	7.0	2.2	1.7	0.6	-1.0	-0.9	1.2	-0.7	-0.2	-2.7	-0.3
Had major operations	1.8	2.1	5.9	-2.4	-0.3	0.6	1.6	1.4	-1.4	1.4	0.9	2.2	1.1
Age at last live birth	1.5	2.2	6.1	1.1	0.4	-1.0	-1.1	-2.1	1.6	-1.7	-1.1	-2.5	-1.0
Family relationship satisfaction	3.4	4.2	10.8	3.0	0.6	-0.3	-1.9	-2.1	3.3	-2.0	-0.5	-2.9	-0.5
Leg pain on walking	1.5	1.9	5.2	0.0	-0.8	-1.5	-2.3	-1.3	1.6	-1.4	-1.2	-0.0	-1.7
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	5.0	-1.6	-2.2	-1.5	-0.0	-0.4	-0.3	-0.6	-0.8	1.4	-0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.1	0.1	0.2	0.3	0.0	0.4	-1.1	0.6	0.4	-0.1	0.7
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.2	1.1	0.1	1.3	1.5	0.9	-0.4	0.8	0.9	-0.3	1.2
Medication: Aspirin	0.2	0.2	1.1	1.0	0.4	-0.1	0.6	-0.1	0.7	-0.2	0.3	-0.2	-0.1
Supplements: Vitamin C	0.3	0.3	1.4	-0.5	0.0	-0.0	0.1	0.6	-1.2	0.5	0.3	0.8	0.4
Knee pain experienced in last month	0.2	0.3	1.6	1.3	0.3	0.2	0.5	0.5	0.4	0.5	0.3	0.6	0.3
Hypertension (Self-reported)	0.8	2.1	6.8	-0.5	-0.3	0.5	2.6	1.8	-1.8	1.2	0.7	1.8	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.3	-0.6	0.0	0.1	0.0	-0.2	-0.1	0.2	-0.3	0.2	-0.1
Illnesses of father: Heart disease	1.6	2.2	4.6	0.8	-0.4	-1.7	-1.0	-2.1	1.0	-1.9	-1.9	-1.2	-1.6
Illnesses of siblings: Diabetes	1.7	2.1	4.1	-0.8	1.0	0.8	2.0	1.7	-1.4	1.5	1.3	2.0	1.3
Smoking status: Previous	0.8	1.2	4.0	1.7	1.7	0.8	-0.2	-0.7	0.7	-0.4	-0.3	-2.0	0.3
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.1	8.8	-1.3	1.3	1.4	3.0	3.0	-1.8	2.2	2.7	2.8	2.3
Whole body fat-free mass	5.4	30.7	72.4	-4.8	-0.1	1.8	6.2	7.3	-5.6	5.6	5.6	8.5	4.8
Leg fat-free mass (right)	5.4	28.7	69.4	-4.5	-0.2	1.6	6.1	7.0	-5.7	5.4	5.2	8.3	4.5
Arm fat percentage (left)	1.0	3.9	8.9	-0.1	-3.0	-3.0	-1.8	-1.7	0.0	-2.2	-2.0	0.3	-2.5
Average weekly red wine intake	0.2	0.2	0.8	-0.6	-0.1	-0.5	-0.2	-0.9	0.4	-0.5	-0.3	-0.6	0.2
Handedness (chirality/laterality): Left-handed	1.4	1.7	5.4	-2.3	-0.2	-0.4	0.9	1.2	-1.7	0.9	0.3	2.2	0.2
Mood swings	1.3	2.3	7.4	1.1	-0.5	-1.0	-2.2	-1.4	2.7	-1.7	-0.8	-0.9	-1.4
Loneliness, isolation	0.3	0.4	2.8	1.7	0.0	-0.4	-0.4	-0.4	0.2	-0.1	-0.1	-0.7	0.2
Long-standing illness, disability or infirmity	0.5	0.8	2.6	1.6	0.3	1.2	-0.6	0.2	0.8	0.2	0.7	-1.3	0.6
Ever had bowel cancer screening	2.4	2.8	11.9	3.5	1.7	1.5	-0.8	-0.8	1.4	-0.4	0.2	-2.7	0.4
Diabetes diagnosed by doctor	0.6	1.0	2.7	0.4	1.0	1.2	1.6	1.1	-0.4	1.0	0.9	0.0	1.0
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.5	6.7	-0.9	-1.1	-1.8	-2.6	-1.7	0.3	-1.8	-1.8	-0.3	-1.8
Friendships satisfaction	3.0	3.7	10.5	2.7	1.4	0.4	-1.8	-1.5	3.2	-1.3	0.6	-3.1	0.1
Qualifications: nursing, teaching	0.6	1.0	5.1	1.1	1.2	1.2	0.2	-0.2	0.1	0.4	0.3	-2.2	0.5
Commuting to job workplace: Walk	0.3	0.3	1.6	-1.3	-0.4	-0.1	0.9	0.1	-0.3	0.2	0.0	0.7	0.3
Eye problems/disorders: Cataract	0.3	0.3	1.6	1.2	-0.0	-0.5	-0.2	-0.4	0.8	-0.6	-0.2	-0.2	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	-0.1	-0.8	-0.8	-0.5	0.1	-0.3	-0.7	-0.2	0.7	-0.8
Medication for cholesterol	0.3	0.5	2.0	-1.4	-1.1	-0.4	-0.7	-0.2	-0.4	-0.0	-0.6	0.6	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	6.6	1.2	-0.6	-0.5	-1.5	-1.7	2.6	-1.8	-1.0	-1.7	-1.3
Back pain experienced in last month	1.2	1.8	5.1	2.2	1.6	0.6	-0.9	-1.1	1.7	-0.2	0.0	-2.2	-0.0
Mineral and other dietary supplements	0.7	1.0	1.8	-1.2	0.1	0.6	1.1	1.3	-1.2	0.8	1.1	1.3	0.4
Breast cancer (self-reported)	0.2	0.3	1.1	0.0	0.4	1.1	-0.6	0.5	-0.2	0.6	0.6	0.0	0.5
Asthma (self-reported)	0.8	1.6	3.5	1.9	0.8	-0.3	-1.6	-1.4	1.2	-1.0	-1.1	-1.7	-0.9
Osteoporosis (self-reported)	1.5	1.8	4.2	-1.4	-2.1	-1.5	-0.4	-1.1	-0.8	-1.4	-1.8	0.3	-1.4
Osteoarthritis (self-reported)	1.4	1.8	10.7	3.3	1.3	1.2	-0.0	0.1	0.8	0.5	0.8	-1.4	0.8
Medication: Aspirin	0.2	0.3	1.6	1.2	0.4	-0.3	0.4	-0.2	0.9	-0.3	0.3	-0.2	-0.2
Medication: Gliclazide	0.9	1.0	3.6	-1.9	-0.0	0.9	0.4	1.2	-0.7	1.0	0.8	1.2	0.9
Illnesses of father: None of the above (group 1)	0.2	0.3	0.7	0.5	0.1	0.7	0.3	0.8	0.5	0.6	0.8	0.2	0.5
Smoking status: Current	0.1	0.2	1.1	-1.0	-0.6	-0.2	-0.4	0.1	0.1	-0.2	-0.3	0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.5	13.4	-2.5	-2.4	-0.9	0.7	1.6	-2.1	1.0	0.7	3.7	-0.2
Whole body water mass	5.4	30.7	73.1	-4.9	-0.1	1.8	6.2	7.2	-5.6	5.5	5.6	8.6	4.7
Leg predicted mass (right)	5.3	28.4	68.1	-4.5	-0.2	1.6	6.1	7.0	-5.6	5.4	5.2	8.3	4.5
Arm fat mass (left)	0.6	2.4	8.8	-1.6	-2.3	-1.8	0.5	1.0	-1.8	0.0	0.2	3.0	-0.5
Number of self-reported non-cancer illnesses	1.4	2.4	13.4	3.7	1.5	1.6	0.9	0.1	0.4	0.2	0.5	-2.0	1.0
Average weekly champagne plus white wine intake	1.4	1.9	4.2	2.1	1.5	1.9	0.9	0.5	0.1	1.3	1.2	-1.2	1.9
Miserableness	0.2	0.3	1.4	0.2	0.4	0.1	-1.2	-0.3	1.1	-0.4	-0.1	-0.4	-0.3
Guilty feelings	2.2	3.3	7.5	1.7	0.3	-0.9	-1.8	-2.4	2.0	-2.2	-1.3	-2.7	-1.3
Wears glasses or contact lenses	0.2	0.2	0.7	0.3	0.1	0.3	0.0	0.3	0.0	0.8	0.4	0.5	0.8
Ever taken oral contraceptive pill	5.2	5.8	10.2	0.6	-1.4	-2.7	-2.5	-3.0	2.4	-3.2	-2.5	-1.7	-2.8
Hearing aid user	0.7	0.8	2.4	1.1	0.0	0.3	-0.2	-0.9	1.3	-0.7	-0.9	-1.6	-0.3
Mother’s age at death	0.3	0.4	2.1	0.6	0.4	0.6	-0.7	-0.4	-0.2	-0.2	0.0	-1.5	-0.1
Financial situation satisfaction	0.2	0.3	0.7	0.4	-0.6	0.4	-0.4	0.3	0.7	0.3	0.9	-0.4	0.6
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.5	0.8	1.2	0.9	1.1	-0.0	0.1	0.9	0.1	-0.9	0.9
Commuting to job workplace: Public transport	0.5	0.6	2.5	1.1	-0.2	-0.7	0.0	-0.7	1.6	-0.6	-0.0	-0.6	-0.6
Eye problems/disorders: Glaucoma	0.5	0.6	1.6	0.5	0.8	1.3	0.7	0.9	-0.3	1.1	0.6	-0.2	0.5
Medication: Blood pressure	0.6	1.1	2.3	-0.4	0.5	0.4	1.5	1.3	-1.5	1.1	0.9	1.1	1.1
Pain type(s) experienced in last month: Hip pain	2.2	2.8	5.4	2.0	-0.3	-0.7	-1.6	-2.1	1.8	-1.6	-1.6	-2.3	-1.7
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.0	0.2	-1.0	-1.1	-1.1	-1.1	0.4	-0.9	-1.4	-0.3	-0.6
High cholesterol (Self-reported)	0.7	1.2	6.7	2.6	1.2	-0.1	1.0	-0.4	0.5	-1.0	0.2	-1.1	-0.0
Medication: Bendroflumethiazide	1.0	1.6	4.5	-0.8	0.5	0.2	2.1	1.2	-1.6	1.0	0.8	1.9	1.0
Medication: Paracetamol	0.5	0.8	2.2	-0.7	-1.5	-1.2	-0.8	-0.1	0.6	-0.7	0.2	1.3	-0.8
Medication: Lisinopril	0.5	0.7	2.7	1.0	1.6	0.7	0.8	-0.4	-0.2	0.1	-0.1	-1.2	0.5
Medication: Atorvastatin	1.2	1.5	3.0	0.3	1.4	1.4	1.4	1.5	-1.7	1.2	1.2	0.2	1.0
Illnesses of father: High blood pressure	0.1	0.1	0.4	-0.4	0.1	0.6	-0.4	0.1	-0.0	0.1	-0.1	-0.3	0.3
Alcohol drinker status: Never	0.4	0.5	1.8	0.1	-0.4	0.1	-0.3	0.9	-1.3	1.0	0.3	0.6	0.7
Ever smoked	0.5	0.8	3.6	1.0	1.9	1.2	0.7	0.3	-0.0	0.3	0.4	-1.0	0.6
Basal metabolic rate	4.6	25.5	66.6	-4.6	-0.5	1.2	5.6	6.6	-5.2	4.8	4.9	8.2	4.0
Leg fat percentage (left)	0.5	1.6	4.0	1.1	-2.0	-1.9	-1.1	-1.1	0.4	-1.4	-1.1	-0.1	-1.4
Arm fat-free mass (left)	4.9	24.6	57.3	-3.9	0.2	1.7	5.5	6.7	-4.9	5.0	5.3	7.6	4.4
Number of operations (self-reported)	0.1	0.1	0.3	0.3	-0.1	0.5	-0.4	-0.4	0.2	-0.1	-0.3	-0.5	-0.1
Average weekly beer plus cider intake	1.2	1.7	6.8	-2.6	-1.6	-1.5	-0.1	-0.4	-0.6	-0.9	-1.0	1.3	-1.1
Irritability	1.7	2.9	5.9	2.3	0.4	-0.4	-2.0	-1.9	2.1	-2.0	-0.8	-2.4	-1.0
Risk taking	1.1	1.6	3.8	0.4	1.9	1.4	1.1	1.1	-0.7	1.4	1.7	-0.3	1.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.9	0.3	-0.1	0.7	0.9	0.2	-0.0	0.4	0.5	-0.1	0.5
Fractured/broken bones in last 5 years	1.3	1.6	3.4	0.8	0.3	-1.4	-1.9	-1.5	1.1	-1.3	-1.4	-0.8	-1.6
Age started oral contraceptive pill	0.2	0.3	1.4	0.5	-1.2	-0.0	-0.1	-0.3	0.7	-0.6	-0.3	-0.5	-0.3
Diastolic blood pressure, automated reading	1.1	3.5	6.9	-2.0	-2.4	-2.6	-0.0	-0.2	-2.6	-0.7	-1.9	2.5	-1.3
Ever depressed for a whole week	0.7	0.9	4.4	2.1	0.4	0.5	-0.0	-0.2	1.7	-0.0	0.5	-0.9	0.4
Unable to work because of sickness or disability	0.4	0.5	3.9	-0.4	0.2	0.2	-2.0	-0.2	0.4	-0.4	-0.2	-0.6	-0.4
Commuting to job workplace: Cycle	1.2	1.4	4.0	0.6	-0.5	-1.1	-2.0	-1.1	1.4	-1.2	-1.1	-0.5	-1.5
Myopia	0.7	1.1	5.2	-1.4	0.6	-0.1	0.9	0.5	-2.3	0.9	-0.3	1.0	0.4
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.5	0.7	0.7	-0.0	-1.9	-0.9	1.5	-0.5	0.3	-1.3	-0.7
Cholesterol lowering medication	0.5	0.8	5.3	2.3	-0.4	-0.7	0.5	-0.3	0.6	-0.8	0.1	-0.6	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	3.1	-0.3	-1.8	-1.1	-0.2	-0.4	0.0	-0.5	-1.0	0.7	-0.6
Pain experienced in last month	0.2	0.3	1.6	-1.0	-1.3	-0.3	-0.4	0.2	0.0	-0.4	0.1	0.6	-0.2
Supplements: Calcium	2.3	2.6	6.8	1.3	2.0	2.6	1.1	1.3	-0.2	1.9	1.6	-0.8	1.9
Basal cell carcinoma (self-reported)	2.5	3.0	5.4	-0.6	0.7	1.9	1.9	2.3	-2.1	2.3	1.4	1.4	1.7
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.0	1.4	0.7	0.9	-0.2	-0.5	1.0	-0.3	0.2	-1.3	0.1
Deep venous thrombosis (DVT) (self-reported)	0.0	0.1	0.3	-0.1	0.3	0.1	0.2	-0.2	-0.1	-0.3	0.2	-0.5	0.0
Heart disease (siblings)	1.0	1.2	6.3	2.5	0.5	-0.3	-0.2	-0.8	1.9	-0.3	-0.3	-1.2	0.1
Alcohol drinker status: Previous	4.0	4.6	11.6	0.4	3.4	3.1	1.5	2.0	-1.3	2.4	2.0	-0.4	2.5
Pack years of smoking	1.2	1.7	6.4	-1.0	-2.5	-1.7	-0.1	-0.5	0.1	-0.8	-1.6	1.0	-1.6
Impedance of whole body	2.0	10.3	20.9	2.2	-0.4	-1.5	-3.6	-4.3	2.6	-3.4	-3.9	-4.6	-3.3
Leg fat mass (left)	0.5	2.0	7.6	-0.8	-2.2	-1.4	1.0	1.2	-1.6	0.3	0.6	2.8	0.0
Arm predicted mass (left)	4.6	23.5	55.5	-3.7	0.1	1.6	5.4	6.5	-4.8	4.9	5.2	7.5	4.3