[Hub]/) : Traits : Diastolic blood pressure, automated reading : ← →

chr2:95,420,294-98,024,837

Best TWAS P=1.55e-13 · Best GWAS P=3.03e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Adipose Visceral Omentum	ADRA2B	0.10	0.04	lasso	3	0.01	8.0e-02	7.3	7.4	1.5e-13	0.98	0.01	0.93	TRUE
60	GTEx	Small Intestine Terminal Ileum	TMEM127	0.27	0.23	lasso	5	0.22	1.0e-05	7.3	7.2	5.5e-13	0.96	0.01	0.96	FALSE
11	GTEx	Adrenal Gland	GPAT2	0.07	0.05	lasso	4	0.02	6.7e-02	6.9	7.2	7.5e-13	0.95	0.02	0.78	FALSE
52	GTEx	Nerve Tibial	LINC00342	0.06	0.05	lasso	4	0.04	7.0e-04	7.0	7.1	1.1e-12	0.94	0.01	0.98	FALSE
69	GTEx	Thyroid	ADRA2B	0.07	0.11	enet	13	0.10	2.4e-08	6.7	7.0	2.1e-12	0.89	0.07	0.93	FALSE
17	GTEx	Brain Frontal Cortex BA9	ITPRIPL1	0.12	0.05	lasso	3	0.03	5.1e-02	6.8	7.0	2.2e-12	0.85	0.02	0.70	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	ADRA2B	0.12	0.07	enet	10	0.09	4.4e-04	6.0	7.0	2.4e-12	0.90	0.04	0.87	FALSE
43	GTEx	Lung	FAHD2CP	0.09	0.10	lasso	5	0.10	4.3e-08	6.0	7.0	2.6e-12	0.88	0.06	0.94	FALSE
53	GTEx	Ovary	FAHD2CP	0.32	0.05	lasso	4	0.06	1.7e-02	6.2	6.9	4.2e-12	0.72	0.03	0.21	FALSE
62	GTEx	Spleen	FAHD2CP	0.18	0.18	lasso	7	0.16	6.4e-05	6.7	6.9	7.4e-12	0.88	0.05	0.86	FALSE
72	METSIM	Adipose	GPAT2	0.01	0.01	blup	119	0.01	4.4e-02	7.0	6.8	9.4e-12	0.93	0.03	0.89	FALSE
75	YFS	Blood	TMEM127	0.03	0.04	enet	6	0.04	1.5e-13	6.0	6.8	9.4e-12	0.92	0.04	0.96	FALSE
54	GTEx	Pancreas	ANKRD36C	0.05	0.05	lasso	4	0.03	1.5e-02	6.9	6.8	1.1e-11	0.88	0.04	0.59	FALSE
56	GTEx	Pancreas	FAHD2CP	0.10	0.15	lasso	3	0.13	5.2e-06	6.8	6.8	1.1e-11	0.87	0.09	0.90	FALSE
47	GTEx	Nerve Tibial	TMEM127	0.05	0.02	lasso	4	0.02	2.7e-02	6.9	6.8	1.4e-11	0.88	0.04	0.93	FALSE
46	GTEx	Muscle Skeletal	FAHD2CP	0.07	0.08	lasso	5	0.08	2.5e-08	6.8	6.7	1.5e-11	0.87	0.09	0.91	FALSE
44	GTEx	Muscle Skeletal	GPAT2	0.13	0.14	enet	11	0.16	1.1e-15	6.7	6.7	1.8e-11	0.88	0.12	0.88	FALSE
86	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GPAT2	0.03	0.03	blup	12	0.03	8.0e-05	6.9	6.7	2.1e-11	0.85	0.00	0.99	FALSE
16	GTEx	Brain Cortex	ITPRIPL1	0.22	0.02	lasso	5	0.02	6.9e-02	7.1	6.7	2.2e-11	0.71	0.03	0.71	FALSE
71	GTEx	Whole Blood	FAHD2CP	0.03	0.01	lasso	4	0.01	3.1e-02	6.7	6.7	2.2e-11	0.84	0.06	0.67	FALSE
66	GTEx	Testis	FAHD2CP	0.14	0.23	lasso	7	0.24	6.8e-11	6.0	6.7	2.4e-11	0.88	0.08	0.92	FALSE
23	GTEx	Colon Transverse	FAHD2CP	0.05	0.01	lasso	4	0.03	1.3e-02	7.3	6.7	2.9e-11	0.77	0.02	0.72	FALSE
24	GTEx	Colon Transverse	LINC00342	0.07	0.05	enet	8	0.09	5.4e-05	6.1	6.6	3.1e-11	0.86	0.06	0.89	FALSE
5	GTEx	Adipose Visceral Omentum	ANKRD36C	0.06	0.05	lasso	2	0.05	1.9e-03	6.4	6.6	4.2e-11	0.90	0.03	0.80	FALSE
41	GTEx	Lung	GPAT2	0.04	0.03	lasso	2	0.02	5.8e-03	6.8	6.6	4.4e-11	0.87	0.03	0.86	FALSE
90	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM127	0.06	0.05	lasso	1	0.05	3.8e-06	6.6	6.6	4.7e-11	0.93	0.00	0.99	FALSE
6	GTEx	Adipose Visceral Omentum	GPAT2	0.06	0.02	lasso	6	0.02	2.9e-02	6.2	6.6	5.2e-11	0.87	0.04	0.73	FALSE
34	GTEx	Heart Left Ventricle	GPAT2	0.08	0.12	enet	7	0.10	7.3e-06	6.4	6.6	5.6e-11	0.86	0.11	0.88	FALSE
8	GTEx	Adipose Visceral Omentum	FAHD2CP	0.09	0.07	lasso	5	0.06	4.0e-04	6.3	6.5	6.0e-11	0.87	0.04	0.88	FALSE
38	GTEx	Liver	LINC00342	0.12	0.03	enet	13	0.06	8.5e-03	7.2	6.5	6.0e-11	0.89	0.02	0.77	FALSE
20	GTEx	Cells Transformed fibroblasts	ITPRIPL1	0.05	0.06	lasso	6	0.02	1.5e-02	6.4	6.5	7.2e-11	0.91	0.03	0.94	FALSE
58	GTEx	Skin Sun Exposed Lower leg	GPAT2	0.04	0.03	enet	16	0.04	3.4e-04	6.4	6.5	8.1e-11	0.80	0.08	0.80	FALSE
3	GTEx	Adipose Subcutaneous	FAHD2CP	0.16	0.08	lasso	6	0.10	1.7e-08	6.8	6.5	1.0e-10	0.81	0.08	0.92	FALSE
57	GTEx	Skin Sun Exposed Lower leg	TMEM127	0.03	0.04	lasso	3	0.03	1.3e-03	7.0	6.5	1.0e-10	0.92	0.02	0.96	FALSE
79	The Cancer Genome Atlas	Colon Adenocarcinoma	ADRA2B	0.07	0.01	blup	23	0.05	9.9e-04	6.9	6.4	1.2e-10	0.88	0.02	0.90	FALSE
70	GTEx	Thyroid	LINC00342	0.09	0.09	lasso	5	0.08	1.3e-06	6.2	6.4	1.8e-10	0.76	0.25	0.74	FALSE
35	GTEx	Heart Left Ventricle	ADRA2B	0.08	0.05	lasso	4	0.05	7.6e-04	6.0	6.4	1.9e-10	0.83	0.10	0.77	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	GPAT2	0.02	0.04	lasso	1	0.03	4.0e-04	6.4	6.4	1.9e-10	0.84	0.01	0.83	FALSE
10	GTEx	Adrenal Gland	CIAO1	0.12	0.09	enet	8	0.10	1.6e-04	6.0	6.4	2.1e-10	0.83	0.06	0.84	FALSE
68	GTEx	Thyroid	GPAT2	0.03	0.02	lasso	3	0.01	5.9e-02	6.3	6.3	2.5e-10	0.84	0.06	0.58	FALSE
39	GTEx	Lung	TMEM127	0.06	0.03	enet	16	0.04	4.1e-04	7.0	6.3	2.7e-10	0.84	0.02	0.98	FALSE
87	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM127	0.05	0.01	blup	21	0.02	2.9e-03	6.6	6.3	2.7e-10	0.83	0.00	0.69	FALSE
31	GTEx	Heart Atrial Appendage	LINC00342	0.05	0.00	enet	8	0.01	1.2e-01	6.2	6.3	3.0e-10	0.80	0.03	0.69	FALSE
92	The Cancer Genome Atlas	Stomach Adenocarcinoma	LOC729234	0.05	0.06	blup	11	0.06	2.0e-05	6.0	6.3	3.5e-10	0.82	0.00	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ITPRIPL1	0.04	0.03	blup	167	0.03	4.8e-05	6.6	6.2	4.3e-10	0.83	0.03	0.97	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	GPAT2	0.08	0.02	enet	6	0.01	1.2e-01	6.0	6.2	4.3e-10	0.84	0.02	0.54	FALSE
76	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CIAO1	0.04	0.01	blup	18	0.03	1.0e-03	7.0	6.2	4.6e-10	0.77	0.01	0.81	FALSE
50	GTEx	Nerve Tibial	ITPRIPL1	0.10	0.03	lasso	4	0.03	1.7e-03	6.3	6.2	6.2e-10	0.86	0.03	0.91	FALSE
88	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ADRA2B	0.05	0.01	blup	22	0.02	6.3e-02	-2.9	6.2	6.9e-10	0.88	0.01	0.51	FALSE
33	GTEx	Heart Left Ventricle	ANKRD36C	0.05	0.04	lasso	4	0.03	1.4e-02	5.5	6.2	7.0e-10	0.82	0.04	0.90	FALSE
37	GTEx	Liver	FAHD2CP	0.18	0.14	lasso	4	0.14	9.3e-05	6.4	6.1	7.8e-10	0.88	0.06	0.76	FALSE
91	The Cancer Genome Atlas	Stomach Adenocarcinoma	ADRA2B	0.03	0.02	blup	22	0.02	6.8e-03	6.2	6.1	1.0e-09	0.86	0.01	0.65	FALSE
4	GTEx	Adipose Visceral Omentum	CIAO1	0.10	0.08	enet	16	0.08	4.8e-05	-4.4	6.1	1.2e-09	0.64	0.44	0.43	FALSE
15	GTEx	Artery Tibial	LINC00342	0.07	0.08	lasso	5	0.08	4.8e-07	5.5	6.1	1.4e-09	0.74	0.25	0.74	FALSE
85	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADRA2B	0.05	0.06	blup	22	0.09	2.2e-10	6.4	6.0	1.5e-09	0.87	0.02	0.98	FALSE
65	GTEx	Testis	CIAO1	0.34	0.24	lasso	9	0.35	1.6e-16	-3.9	6.0	1.6e-09	0.79	0.04	0.96	FALSE
36	GTEx	Heart Left Ventricle	FAHD2CP	0.10	0.02	lasso	4	0.03	7.6e-03	5.3	6.0	2.0e-09	0.79	0.08	0.61	FALSE
78	The Cancer Genome Atlas	Breast Invasive Carcinoma	STARD7	0.02	0.00	enet	7	0.01	1.4e-03	7.0	-6.0	2.1e-09	-0.70	0.00	0.60	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM127	0.05	0.02	blup	20	0.01	1.8e-02	7.0	6.0	2.1e-09	0.89	0.00	0.85	FALSE
22	GTEx	Colon Transverse	ADRA2B	0.07	0.10	lasso	1	0.06	6.3e-04	6.0	6.0	2.2e-09	0.80	0.08	0.67	FALSE
74	YFS	Blood	ARID5A	0.06	0.04	lasso	8	0.05	3.9e-17	5.3	6.0	2.7e-09	0.65	1.00	0.00	FALSE
80	The Cancer Genome Atlas	Colon Adenocarcinoma	CIAO1	0.04	0.02	blup	18	0.04	1.9e-03	-3.9	5.9	2.8e-09	0.69	0.01	0.60	FALSE
83	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GPAT2	0.02	0.02	lasso	2	0.01	1.0e-02	6.1	5.9	2.9e-09	0.77	0.01	0.57	FALSE
45	GTEx	Muscle Skeletal	ADRA2B	0.04	0.00	lasso	7	0.00	6.3e-01	7.3	5.9	3.3e-09	0.90	0.02	0.53	FALSE
29	GTEx	Esophagus Muscularis	ADRA2B	0.09	0.05	enet	17	0.06	9.0e-05	6.8	5.9	3.6e-09	0.70	0.07	0.88	FALSE
59	GTEx	Skin Sun Exposed Lower leg	LINC00342	0.05	0.05	enet	9	0.04	5.9e-04	6.2	5.9	3.6e-09	0.74	0.15	0.64	FALSE
18	GTEx	Breast Mammary Tissue	ARID5A	0.06	0.00	lasso	3	0.00	2.8e-01	5.0	5.9	3.7e-09	0.78	0.02	0.69	FALSE
49	GTEx	Nerve Tibial	GPAT2	0.09	0.08	lasso	3	0.07	9.1e-06	6.0	5.9	4.4e-09	0.80	0.32	0.56	FALSE
40	GTEx	Lung	CIAO1	0.11	0.12	lasso	2	0.16	1.6e-12	-3.9	5.9	4.7e-09	0.74	0.18	0.82	FALSE
2	GTEx	Adipose Subcutaneous	GPAT2	0.04	0.03	enet	12	0.03	2.6e-03	6.8	5.9	4.8e-09	0.80	0.07	0.84	FALSE
63	GTEx	Stomach	GPAT2	0.17	0.16	lasso	2	0.12	2.0e-06	6.0	5.8	5.0e-09	0.80	0.12	0.87	FALSE
19	GTEx	Breast Mammary Tissue	ADRA2B	0.08	0.00	enet	11	0.01	6.6e-02	6.1	5.8	5.1e-09	0.85	0.02	0.85	FALSE
73	ROSMAP	Brain Pre-frontal Cortex	ITPRIPL1	0.05	0.03	lasso	10	0.04	4.0e-06	5.2	5.8	5.7e-09	0.82	0.12	0.88	FALSE
77	The Cancer Genome Atlas	Breast Invasive Carcinoma	NCAPH	0.01	0.00	blup	28	0.01	1.4e-02	-4.4	-5.8	5.7e-09	-0.71	0.03	0.48	FALSE
81	The Cancer Genome Atlas	Colon Adenocarcinoma	LOC285033	0.32	0.07	enet	7	0.12	3.5e-07	7.0	5.8	6.2e-09	0.73	0.00	0.95	FALSE
48	GTEx	Nerve Tibial	CIAO1	0.11	0.05	enet	12	0.10	2.2e-07	-4.4	5.8	7.1e-09	0.74	0.06	0.94	FALSE
9	GTEx	Adipose Visceral Omentum	LINC00342	0.12	0.01	enet	23	0.06	7.5e-04	1.5	5.7	1.0e-08	0.59	0.06	0.68	FALSE
14	GTEx	Artery Tibial	FAHD2CP	0.07	0.06	lasso	4	0.06	3.1e-05	6.1	5.7	1.1e-08	0.81	0.17	0.62	FALSE
51	GTEx	Nerve Tibial	ADRA2B	0.11	0.11	enet	6	0.11	5.0e-08	6.0	5.7	1.2e-08	0.82	0.29	0.71	FALSE
64	GTEx	Stomach	FAHD2CP	0.10	0.06	enet	14	0.08	7.9e-05	6.3	5.7	1.2e-08	0.76	0.08	0.83	FALSE
28	GTEx	Esophagus Muscularis	GPAT2	0.11	0.11	lasso	4	0.11	2.6e-07	6.0	5.7	1.5e-08	0.81	0.30	0.69	FALSE
84	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NEURL3	0.03	0.02	lasso	3	0.02	6.9e-03	5.3	5.6	2.3e-08	0.71	0.00	0.80	FALSE
82	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM127	0.06	0.05	blup	19	0.07	1.2e-04	-3.9	5.5	3.3e-08	0.61	0.03	0.77	FALSE
61	GTEx	Spleen	CIAO1	0.22	-0.01	enet	20	0.14	2.3e-04	-4.3	5.4	5.6e-08	0.72	0.05	0.63	FALSE
13	GTEx	Artery Tibial	CIAO1	0.06	0.06	lasso	4	0.04	2.8e-04	-3.9	5.4	8.1e-08	0.64	0.18	0.78	FALSE
30	GTEx	Heart Atrial Appendage	TMEM127	0.10	0.02	lasso	4	0.02	4.6e-02	5.3	5.3	9.6e-08	0.70	0.07	0.46	FALSE
12	GTEx	Artery Tibial	TMEM127	0.04	0.02	lasso	5	0.01	3.4e-02	-2.9	5.3	9.8e-08	0.80	0.04	0.81	FALSE
89	The Cancer Genome Atlas	Prostate Adenocarcinoma	GPAT2	0.03	0.04	lasso	2	0.03	2.0e-04	5.5	5.3	1.0e-07	0.71	0.02	0.52	FALSE
42	GTEx	Lung	ITPRIPL1	0.11	0.06	lasso	7	0.13	7.3e-10	-3.5	5.3	1.1e-07	0.82	0.03	0.97	FALSE
21	GTEx	Colon Transverse	FAHD2A	0.15	0.15	lasso	2	0.14	3.8e-07	4.8	5.3	1.4e-07	0.65	0.40	0.37	FALSE
55	GTEx	Pancreas	ITPRIPL1	0.12	0.01	enet	21	0.06	1.7e-03	-2.8	5.2	1.6e-07	0.70	0.08	0.72	FALSE
27	GTEx	Esophagus Muscularis	CIAO1	0.05	0.02	lasso	4	0.04	1.8e-03	-4.1	5.2	1.8e-07	0.60	0.07	0.52	FALSE
67	GTEx	Thyroid	ANKRD36C	0.07	0.01	lasso	5	0.00	1.4e-01	2.0	5.2	2.5e-07	0.56	0.02	0.25	FALSE
32	GTEx	Heart Left Ventricle	LMAN2L	0.07	0.00	enet	12	0.01	1.1e-01	3.2	5.2	2.6e-07	0.62	0.05	0.65	FALSE