TWAS hub - ADRA2B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.0990	0.0560	9.4e-04	0.037	NA	0.006	NA	0.011	4.9e-03	NA	1.5e-01	NA	8.0e-02
2	GTEx	Brain Cerebellum	0.4290	0.1010	4.9e-05	0.243	NA	0.151	NA	0.222	8.6e-08	NA	3.2e-05	NA	3.5e-07
3	GTEx	Breast Mammary Tissue	0.0830	0.0450	1.3e-03	0.000	NA	0.013	NA	0.007	3.1e-01	NA	6.6e-02	NA	1.3e-01
4	GTEx	Breast Mammary Tissue (Female)	0.0451	0.0331	6.7e-02	0.014	NA	-0.007	NA	-0.010	1.2e-01	NA	6.2e-01	NA	8.7e-01
5	GTEx	Colon Transverse	0.0710	0.0400	3.0e-03	0.096	NA	0.026	NA	0.063	2.5e-05	NA	2.0e-02	NA	6.3e-04
6	GTEx	Esophagus Gastroesophageal Junction	0.1210	0.0590	4.0e-04	0.068	NA	0.088	NA	0.072	1.8e-03	NA	4.4e-04	NA	1.4e-03
7	GTEx	Esophagus Muscularis	0.0870	0.0460	2.9e-04	0.052	NA	0.065	NA	0.054	4.4e-04	NA	9.0e-05	NA	3.2e-04
8	GTEx	Heart Left Ventricle	0.0782	0.0391	3.7e-04	0.050	NA	0.050	NA	0.054	1.1e-03	NA	1.2e-03	NA	7.6e-04
9	GTEx	Muscle Skeletal	0.0442	0.0249	5.1e-03	0.001	NA	-0.002	NA	-0.002	2.6e-01	NA	6.4e-01	NA	6.3e-01
10	GTEx	Nerve Tibial	0.1095	0.0446	1.3e-06	0.106	NA	0.108	NA	0.106	6.5e-08	NA	5.0e-08	NA	5.8e-08
11	GTEx	Thyroid	0.0710	0.0250	1.1e-08	0.109	NA	0.104	NA	0.104	1.0e-08	NA	2.4e-08	NA	2.5e-08
12	TCGA	Colon Adenocarcinoma	0.0650	0.0440	6.3e-04	0.014	0.047	0.037	NA	0.038	5.1e-02	9.9e-04	3.2e-03	NA	2.8e-03
13	TCGA	Kidney Renal Clear Cell Carcinoma	0.0528	0.0254	1.2e-09	0.060	0.091	0.088	NA	0.085	2.4e-07	2.2e-10	4.2e-10	NA	8.5e-10
14	TCGA	Brain Lower Grade Glioma	0.0841	0.0484	1.7e-03	0.015	0.017	0.016	NA	0.015	6.5e-03	4.4e-03	5.3e-03	NA	6.4e-03
15	TCGA	Pheochromocytoma and Paraganglioma	0.0530	0.0380	8.8e-03	0.014	0.018	0.010	NA	0.014	8.4e-02	6.3e-02	1.3e-01	NA	8.6e-02
16	TCGA	Stomach Adenocarcinoma	0.0290	0.0200	4.5e-03	0.018	0.024	0.002	NA	0.014	1.7e-02	6.8e-03	2.1e-01	NA	3.0e-02
17	TCGA	Thyroid Carcinoma	0.0580	0.0410	1.7e-03	0.021	0.031	0.039	NA	0.020	3.8e-03	4.7e-04	9.3e-05	NA	4.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17
Blood Eosinophil Count	38.1	293.1	424.4	18.0	-7.4	18.8	16.6	17.0	20.2	15.1	20.6	16.2	17.5	18.6	20.1	19.7	-6.7	19.2	18.9	12.2
Diastolic blood pressure, automated reading	10.8	33.3	54.5	7.4	-3.9	5.8	4.0	6.0	7.0	5.9	6.4	5.9	5.7	7.0	6.4	6.0	-3.2	6.2	6.1	2.6
Comparative body size at age 10	6.4	17.6	25.3	-4.7	3.5	-4.6	-2.9	-4.5	-5.0	-3.9	-4.7	-3.8	-4.2	-4.7	-4.6	-4.3	3.9	-4.3	-4.5	-2.1
Ever unenthusiastic/disinterested for a whole week	5.4	6.6	12.0	-2.8	3.5	-2.3	-0.8	-3.2	-3.5	-1.6	-3.4	-0.9	-2.6	-3.2	-2.9	-2.3	2.7	-2.3	-2.5	0.2
Medication: Ibuprofen	4.8	5.8	9.5	-2.7	1.2	-1.9	-0.7	-2.8	-3.0	-3.1	-2.8	-2.4	-2.6	-2.5	-2.6	-2.5	2.0	-2.5	-2.6	-1.4
Pulse rate, automated reading	4.8	15.5	21.3	4.4	-2.1	4.2	3.5	3.9	4.6	3.2	4.5	4.6	4.1	4.1	4.4	4.3	-2.2	4.3	4.4	2.9
Pulse rate	4.2	7.2	9.8	2.8	-2.4	3.1	2.5	2.7	2.8	2.6	2.8	2.7	2.7	2.6	2.8	2.8	-2.5	2.8	2.9	1.4
Medication: Ramipril	4.1	5.2	9.6	2.1	-1.9	1.3	-0.9	2.6	2.8	3.1	3.0	1.4	2.5	2.8	2.5	2.1	-2.7	2.1	2.4	0.9
Mouth/teeth dental problems: Dentures	4.0	6.8	14.3	2.1	1.0	2.2	2.2	2.7	2.7	2.3	2.7	2.1	3.2	2.5	3.0	3.2	0.7	3.2	3.0	3.8
Friendships satisfaction	4.0	5.0	7.6	-2.4	1.1	-2.7	-2.1	-2.4	-2.8	-1.4	-2.7	-2.0	-2.5	-2.2	-2.5	-2.4	1.4	-2.4	-2.5	-1.4
Basal cell carcinoma (self-reported)	3.9	4.6	7.9	-2.0	2.2	-2.2	-1.8	-2.3	-2.3	-2.0	-2.8	-1.8	-2.2	-2.1	-2.4	-2.1	2.7	-1.9	-2.1	-0.6
Supplements: Zinc	3.8	4.1	11.2	-2.3	3.3	-1.6	-0.4	-1.7	-2.1	-2.2	-2.0	-1.7	-1.4	-2.1	-2.2	-1.8	3.2	-1.7	-1.9	1.2
Loud music exposure frequency	3.8	4.2	9.9	-1.4	1.1	-0.8	0.3	-3.1	-2.4	-2.4	-2.9	-1.0	-2.6	-2.0	-2.3	-2.0	2.5	-1.8	-2.2	-1.3
Myopia	3.8	5.5	9.0	-2.3	1.0	-3.0	-2.4	-2.4	-2.6	-2.5	-2.6	-2.3	-2.6	-2.5	-2.3	-2.4	1.2	-2.5	-2.5	-1.8
Qualifications: nursing, teaching	3.5	5.4	11.2	-3.2	2.7	-1.9	-1.2	-2.3	-3.0	-1.1	-2.7	-2.4	-1.9	-3.3	-2.7	-2.4	1.2	-2.5	-2.4	-0.4
Vitamin and mineral supplements	3.4	4.6	9.6	3.1	-1.2	1.2	0.5	2.4	2.8	1.6	2.2	2.5	2.2	2.5	2.6	2.5	0.1	2.7	2.4	0.9
Medication: Ibuprofen (e.g. Nurofen)	3.3	4.1	6.7	-2.4	1.1	-1.4	-0.5	-2.5	-2.6	-2.1	-2.4	-2.0	-2.3	-2.2	-2.3	-2.3	1.1	-2.3	-2.3	-1.3
Health satisfaction	3.2	4.2	7.5	-1.8	2.7	-1.6	-1.3	-2.5	-2.6	-1.3	-2.3	-1.3	-2.2	-2.4	-2.3	-2.1	2.0	-2.2	-2.3	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	3.1	7.0	10.3	2.7	0.0	2.9	2.5	2.6	3.2	2.4	3.0	2.5	2.8	2.9	3.0	3.1	0.1	3.1	3.0	2.5
Serious illness, injury or assault to yourself	3.1	3.8	8.7	-3.0	2.5	-2.2	-1.4	-2.0	-2.6	-2.3	-2.3	-2.1	-1.5	-2.5	-1.5	-1.3	1.1	-1.4	-1.4	0.1
Had major operations	3.1	3.6	4.9	2.0	-0.8	1.4	1.9	1.9	2.1	1.2	2.0	2.2	2.2	2.2	2.1	2.2	-0.1	2.2	2.1	1.9
Alzheimer’s Disease (in father)	3.0	3.2	6.9	-1.9	0.2	-1.0	-0.9	-2.1	-2.1	-1.4	-1.9	-2.6	-2.0	-1.8	-1.8	-2.0	0.0	-2.0	-2.0	-2.2
Hip circumference	3.0	12.9	19.6	-3.0	2.5	-4.4	-3.5	-4.3	-3.5	-4.0	-3.8	-3.6	-3.9	-3.1	-3.8	-3.6	3.9	-3.4	-3.8	-1.9
Family relationship satisfaction	3.0	3.7	5.5	-2.2	1.5	-1.8	-1.5	-2.4	-2.2	-0.9	-1.8	-1.8	-2.2	-2.1	-2.2	-2.2	1.3	-2.3	-2.3	-1.1
Average weekly champagne plus white wine intake	2.9	4.0	6.1	-2.3	2.0	-2.3	-2.5	-1.9	-2.4	-1.1	-2.4	-1.7	-1.7	-2.3	-2.3	-2.0	1.6	-1.9	-1.9	0.3
High cholesterol (Self-reported)	2.9	5.2	10.6	3.3	-1.9	2.3	1.6	2.3	3.0	2.1	2.6	1.8	2.2	3.0	2.6	2.4	-1.1	2.3	2.2	0.7
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	12.5	-1.2	3.4	-1.2	0.6	-2.2	-1.7	-1.6	-2.0	-0.8	-1.0	-1.5	-0.8	-0.5	3.5	-0.6	-0.9	1.7
Age at First Birth	2.7	3.9	6.4	1.8	-1.0	2.1	1.0	2.4	2.4	1.9	2.3	0.9	2.4	2.5	2.2	2.1	-1.4	2.2	2.2	1.2
Medication: Lansoprazole	2.7	3.0	5.9	0.8	-0.0	1.7	1.9	2.1	1.4	1.9	2.0	1.2	2.4	1.4	2.2	2.1	-0.7	1.9	2.0	1.9
Peak expiratory flow (PEF)	2.7	6.3	11.0	2.8	-0.4	2.5	1.9	2.5	2.7	1.6	2.4	2.9	3.0	2.9	2.5	2.8	-0.2	3.0	2.8	3.3
Impedance of leg (right)	2.6	12.8	18.0	4.2	-1.7	3.9	3.4	3.5	4.2	3.1	3.8	3.9	3.7	3.8	4.0	4.0	-1.6	4.0	4.0	2.5
Impedance of leg (left)	2.6	12.8	18.1	4.2	-2.2	4.0	3.6	3.5	4.1	3.0	3.5	4.1	3.5	3.8	3.9	3.9	-1.8	4.0	3.9	2.4
Mouth/teeth dental problems	2.6	4.0	6.8	-2.0	-0.5	-1.9	-1.2	-1.6	-2.2	-1.8	-1.9	-1.7	-1.9	-2.4	-2.6	-2.6	0.6	-2.6	-2.5	-2.5
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.1	5.4	-1.2	-0.5	-1.7	-1.1	-2.1	-1.5	-2.1	-1.8	-1.9	-2.3	-1.7	-1.7	-2.0	1.0	-2.0	-2.1	-2.2
Supplements: Vitamin C	2.6	3.1	7.5	-2.7	1.3	-1.3	-1.5	-1.4	-2.2	-1.1	-1.8	-2.5	-1.5	-1.6	-2.1	-2.0	0.4	-2.1	-1.9	-0.1
Ever depressed for a whole week	2.6	3.1	5.7	-2.0	1.5	-1.3	-0.7	-1.9	-2.3	-0.7	-2.0	-1.0	-2.0	-2.4	-2.1	-2.1	1.2	-2.1	-2.1	-1.3
Heel T-Score	2.5	19.8	33.1	5.7	-2.9	3.9	2.4	4.6	5.7	4.8	4.9	4.5	4.1	5.8	4.8	4.8	-1.8	5.0	4.9	2.3
Nervous feelings	2.5	4.7	6.3	2.3	-1.2	2.1	1.7	2.2	2.3	2.1	2.1	2.2	2.1	2.4	2.5	2.4	-1.9	2.3	2.5	1.9
Medication: Simvastatin	2.5	3.6	8.0	2.8	-0.3	2.1	0.8	2.0	2.3	1.9	1.8	1.8	2.0	2.5	2.3	1.9	-1.1	1.9	2.0	1.0
Migraine (self-reported)	2.4	3.0	5.3	-2.2	1.3	-1.4	-0.2	-2.0	-2.3	-1.4	-2.2	-1.1	-1.9	-2.3	-2.2	-1.9	1.0	-1.9	-1.9	-0.7
Ulcerative Colitis (UC)	2.3	4.4	7.1	2.2	-0.4	1.6	0.6	1.8	2.3	2.4	2.4	2.2	2.7	2.5	2.3	2.2	-1.0	2.1	2.3	2.6
Ovarian Cancer	2.3	3.0	6.4	-1.5	2.0	-1.8	-0.8	-2.5	-2.0	-1.6	-2.1	-0.9	-1.9	-2.1	-1.6	-1.6	1.8	-1.7	-1.8	-0.1
Heart disease (siblings)	2.3	2.8	5.2	-2.3	1.3	-1.9	-1.8	-1.8	-1.8	-0.8	-1.9	-2.1	-1.8	-1.7	-1.8	-1.7	1.2	-1.6	-1.6	-0.3
Bipolar Disorder or Schizophrenia	2.2	5.5	12.4	-3.5	2.4	-2.4	-0.6	-2.1	-3.4	-2.5	-3.1	-2.1	-2.0	-3.4	-1.9	-1.5	2.2	-1.7	-1.8	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.0	8.3	2.7	0.2	2.4	1.6	2.2	2.9	2.0	2.6	2.2	2.3	2.6	2.5	2.6	0.3	2.6	2.4	1.8
Qualifications: None of the above	2.2	4.7	7.3	2.7	-0.7	2.2	1.6	2.5	2.7	1.6	2.7	2.7	2.4	2.7	2.3	2.2	-0.5	2.2	2.1	0.9
Chronic bronchitis/emphysema (mother)	2.2	2.6	4.7	2.0	-0.1	2.1	1.9	1.6	1.7	1.4	1.6	1.4	1.7	1.8	2.2	1.8	-0.4	1.7	1.6	0.5
Alzheimer’s Disease (in mother)	2.1	2.5	4.9	1.3	-1.6	1.7	1.1	1.5	1.8	2.2	2.0	1.2	1.7	1.3	1.6	1.4	-2.0	1.3	1.6	0.7
Crohns Disease (2012)	2.1	3.4	4.8	-2.0	-0.2	-1.9	-2.1	-1.7	-1.8	-1.7	-1.8	-2.1	-1.9	-1.9	-2.0	-2.2	-1.0	-2.2	-1.9	-1.7
Ulcerative Colitis	2.1	3.1	5.1	2.1	-0.5	1.4	0.8	1.3	1.8	1.8	1.6	2.2	2.0	2.0	2.1	2.0	-0.3	1.9	2.0	2.3
Allergy or Eczema	2.1	5.4	13.4	-2.0	-0.7	-2.1	-2.7	-2.1	-1.5	-2.0	-1.2	-3.7	-2.7	-1.9	-2.4	-2.8	-0.3	-2.9	-2.8	-3.1
Chronic bronchitis/emphysema (father)	2.0	2.3	9.1	-1.3	3.0	-1.1	-0.4	-1.3	-1.2	-2.3	-1.2	-1.6	-0.7	-1.3	-1.0	-0.9	2.8	-0.9	-1.1	1.0
Illnesses of mother	2.0	2.5	5.8	-1.5	0.9	-1.7	-1.1	-2.0	-1.6	-2.4	-1.8	-1.9	-1.9	-1.5	-1.2	-1.3	0.8	-1.5	-1.5	-1.2
Medication: Ventolin 100micrograms inhaler	1.9	2.4	6.1	-1.7	-1.0	-1.5	-2.5	-0.8	-1.1	-1.6	-0.5	-1.9	-1.3	-1.4	-1.3	-1.6	-1.6	-1.7	-1.4	-2.1
Commuting to job workplace: Public transport	1.9	2.3	4.9	1.6	0.3	1.2	0.3	1.5	1.5	2.2	1.4	1.3	1.6	1.5	1.9	1.8	-0.6	1.8	1.9	1.7
Chronotype (morning person)	1.8	4.2	8.8	2.5	-3.0	1.8	0.2	2.5	2.5	2.5	1.9	2.1	1.6	2.5	1.5	1.6	-2.4	1.8	2.0	0.4
Hayfever, allergic rhinitis or eczema	1.8	3.8	10.0	-1.4	-1.3	-1.6	-2.3	-1.8	-1.1	-1.3	-0.9	-2.6	-2.3	-1.3	-2.0	-2.5	-0.6	-2.5	-2.4	-3.2
Guilty feelings	1.8	2.8	5.1	-2.0	1.4	-1.7	-0.7	-1.6	-1.9	-2.0	-1.7	-1.5	-1.6	-2.3	-1.6	-1.7	1.3	-1.8	-1.8	-1.0
Bipolar Disorder (2018)	1.7	2.6	9.1	-2.1	3.0	-1.4	-0.2	-1.4	-2.0	-1.7	-1.9	-1.4	-0.9	-2.0	-1.2	-0.9	2.3	-0.9	-1.1	0.7
Cardiovascular Disease	1.7	5.6	11.9	3.2	-3.4	2.2	0.9	2.1	3.0	2.1	2.7	2.1	1.7	3.4	2.4	2.0	-2.1	2.2	2.1	-0.6
Alcohol intake frequency.	1.7	3.9	7.4	-1.9	1.0	-2.7	-2.5	-2.3	-2.2	-1.8	-2.3	-1.9	-2.1	-2.2	-1.7	-1.9	0.6	-2.1	-2.0	-1.4
Leg fat-free mass (right)	1.7	9.1	12.2	-2.7	2.1	-3.2	-2.5	-3.5	-3.3	-3.2	-3.5	-2.9	-3.2	-2.9	-3.3	-3.1	3.4	-2.9	-3.3	-1.6
Leg predicted mass (right)	1.7	9.2	12.4	-2.7	2.1	-3.3	-2.6	-3.5	-3.3	-3.2	-3.5	-2.9	-3.2	-2.9	-3.3	-3.1	3.4	-2.9	-3.3	-1.6
Schizophrenia (2018)	1.6	3.2	8.2	-2.9	0.7	-2.0	-0.6	-1.6	-2.7	-1.9	-2.4	-1.7	-1.7	-2.7	-1.5	-1.2	0.9	-1.4	-1.5	-1.1
Reaction Time	1.6	3.0	7.6	-1.9	1.6	-0.9	-1.0	-2.2	-2.5	-1.2	-2.8	-2.2	-2.2	-2.0	-1.5	-1.6	0.4	-1.6	-1.5	-0.5
Prostate Cancer	1.6	2.3	4.6	1.6	-0.9	1.8	1.4	1.6	1.6	2.1	1.4	1.8	1.3	2.0	1.2	1.4	-0.4	1.6	1.6	1.2
Coronary Artery Disease (CAD)	1.6	2.0	4.5	-0.3	0.3	-1.8	-2.1	-1.3	-1.3	-0.7	-1.5	-1.0	-1.3	-1.2	-1.8	-1.8	0.6	-1.9	-1.8	-1.3
BMI	1.6	9.2	17.0	-2.5	0.8	-3.4	-3.0	-3.6	-2.9	-4.1	-2.8	-3.5	-3.6	-2.5	-2.8	-3.0	1.8	-3.0	-3.3	-3.2
Leg fat-free mass (left)	1.6	8.7	12.2	-2.6	2.4	-3.2	-2.6	-3.5	-3.1	-3.0	-3.3	-3.0	-3.1	-2.8	-3.1	-3.0	3.5	-2.8	-3.2	-1.5
Multivitamins +/- minerals	1.6	2.0	3.9	-2.0	1.0	-0.4	0.7	-1.6	-1.8	-1.5	-1.4	-1.4	-1.5	-1.6	-1.7	-1.6	0.7	-1.7	-1.7	-0.7
Stomach or abdominal pain in last month	1.6	2.0	3.2	1.5	-0.2	1.6	1.5	1.2	1.8	1.0	1.6	1.0	1.5	1.6	1.8	1.7	-0.3	1.7	1.6	1.5
Body mass index (BMI)	1.6	6.7	10.6	-2.4	1.6	-3.2	-3.0	-3.0	-2.5	-2.7	-2.4	-3.2	-2.9	-2.2	-2.4	-2.6	2.0	-2.6	-2.8	-2.1
Leg predicted mass (left)	1.6	8.6	11.8	-2.6	2.4	-3.2	-2.7	-3.4	-3.1	-3.0	-3.3	-3.0	-3.0	-2.7	-3.1	-2.9	3.4	-2.7	-3.1	-1.5
Medication: Blood pressure	1.6	3.1	5.2	2.2	-2.3	1.9	0.8	2.0	2.1	1.5	1.9	1.6	1.4	2.2	1.9	1.6	-1.8	1.6	1.7	-0.2
Impedance of whole body	1.6	8.0	10.7	3.2	-2.6	2.9	2.3	3.3	3.2	2.9	3.2	3.3	3.1	3.0	2.6	2.7	-2.1	2.8	2.9	1.4
Current tobacco smoking	1.5	2.4	4.2	-1.3	1.5	-2.1	-1.2	-1.7	-1.6	-1.8	-1.5	-0.5	-1.7	-1.8	-1.7	-1.7	1.0	-1.7	-1.7	-0.9
High blood pressure	1.5	4.3	7.6	2.5	-2.7	1.6	-0.1	2.2	2.7	2.2	2.8	1.2	1.8	2.7	2.3	1.8	-2.3	1.8	1.9	-0.4
Supplements: Glucosamine	1.5	2.0	4.8	1.0	0.4	1.4	2.0	1.2	1.2	0.5	1.4	1.3	1.5	1.1	1.4	1.7	0.7	1.7	1.6	2.2
Alcohol usually taken with meals	1.5	2.5	4.3	-0.7	0.2	-1.7	-1.5	-1.8	-1.5	-1.2	-2.1	-1.2	-2.0	-1.5	-1.9	-1.9	1.4	-1.7	-1.9	-1.5
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	5.0	-1.7	0.9	-1.5	-1.0	-1.8	-2.1	-0.9	-1.9	-2.2	-1.5	-2.2	-1.4	-1.3	0.6	-1.5	-1.5	-0.7
Number of full brothers	1.5	1.9	4.8	1.6	1.9	0.8	0.5	1.2	1.3	0.9	1.1	1.8	1.5	1.3	1.4	1.4	0.8	1.4	1.4	2.2
Arm fat mass (left)	1.5	6.2	10.6	-2.2	1.3	-3.1	-3.0	-2.7	-2.3	-2.6	-2.3	-3.2	-2.6	-2.1	-2.4	-2.5	2.3	-2.5	-2.7	-2.0
Body Mass Index (BMI) (2010)	1.4	1.9	3.4	-1.3	1.5	-1.0	-0.5	-1.8	-1.6	-1.6	-1.8	-1.3	-1.5	-1.6	-1.2	-1.2	1.4	-1.2	-1.4	-0.7
Waist circumference	1.4	5.1	8.4	-1.7	2.6	-2.9	-2.6	-2.7	-2.0	-2.7	-2.2	-2.8	-2.3	-1.8	-1.7	-1.9	2.8	-1.9	-2.1	-0.9
Arm fat mass (right)	1.4	5.8	9.2	-2.0	1.2	-3.0	-2.9	-2.6	-2.2	-2.5	-2.2	-3.0	-2.5	-2.0	-2.4	-2.5	2.2	-2.4	-2.7	-1.9
Illnesses of father: None of the above (group 1)	1.4	1.7	2.5	1.4	-1.4	1.3	0.7	1.2	1.4	1.1	1.3	1.3	1.3	1.3	1.6	1.5	-1.5	1.4	1.5	0.6
Wears glasses or contact lenses	1.4	1.6	4.2	1.2	-2.1	0.7	0.0	1.7	1.2	1.0	1.0	1.3	1.4	1.0	1.4	1.3	-1.9	1.2	1.4	0.5
Illnesses of father: High blood pressure	1.4	1.7	4.6	1.3	-2.1	0.9	-0.1	1.7	1.6	1.5	2.0	0.7	1.1	1.2	1.0	0.8	-1.9	0.8	0.9	-0.7
Commuting to job workplace: Cycle	1.4	1.7	3.2	-1.3	1.0	-0.9	0.0	-1.2	-1.8	-1.5	-1.4	-0.8	-1.2	-1.7	-1.4	-1.3	1.4	-1.3	-1.4	-1.2
Schizophrenia (2014)	1.3	2.8	7.1	-2.7	1.2	-2.0	-0.5	-1.7	-2.4	-1.9	-2.3	-1.8	-1.6	-2.2	-1.0	-0.8	1.7	-0.9	-1.1	-0.2
Had menopause	1.3	1.6	4.2	-1.5	-1.4	-1.2	-1.4	-0.1	-1.3	0.6	-0.8	-1.4	-0.7	-1.4	-1.1	-1.2	-2.1	-1.4	-1.0	-1.6
Allergy	1.3	3.0	8.0	0.8	0.5	1.6	2.3	1.6	1.0	1.3	0.8	2.0	1.9	1.1	1.9	2.3	0.3	2.4	2.3	2.8
Weight	1.3	6.1	10.5	-2.0	2.1	-3.0	-2.5	-3.0	-2.4	-2.7	-2.6	-2.6	-2.6	-2.1	-2.4	-2.3	3.2	-2.2	-2.6	-1.1
Eye problems/disorders: None of the above	1.3	1.5	5.2	1.2	1.4	0.8	0.6	1.1	1.2	1.1	1.0	1.4	1.5	0.6	1.3	1.4	0.2	1.2	1.3	2.3
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	6.8	-1.3	1.5	-1.4	-0.4	-2.0	-1.3	-1.9	-1.3	-0.9	-1.5	-1.7	-2.1	-1.9	2.6	-1.8	-2.1	-0.4
Osteoporosis (self-reported)	1.3	1.6	7.7	0.1	-1.1	0.0	-1.7	1.8	1.0	2.2	1.2	0.4	1.1	1.4	0.3	0.4	-2.8	0.4	0.9	0.2
Smoking status: Current	1.3	2.0	4.2	-1.2	1.1	-2.0	-1.2	-1.7	-1.4	-1.7	-1.2	-0.6	-1.6	-1.6	-1.5	-1.5	0.9	-1.5	-1.6	-0.8
Average weekly spirits intake	1.2	1.4	3.5	-1.5	1.1	-0.4	-0.0	-1.2	-1.0	-1.3	-0.7	-1.9	-1.4	-1.2	-1.4	-1.3	1.1	-1.3	-1.4	-0.7
Average weekly fortified wine intake	1.2	1.4	8.5	-1.3	2.9	-0.4	0.4	-0.6	-1.1	-0.5	-0.9	-0.6	-0.1	-1.4	-0.6	-0.4	2.4	-0.4	-0.6	1.4
Arm fat percentage (right)	1.2	4.9	9.4	-2.0	0.3	-2.8	-3.0	-2.2	-1.9	-1.9	-1.8	-3.1	-2.3	-1.8	-2.2	-2.4	1.1	-2.4	-2.5	-2.3
Arm fat percentage (left)	1.2	5.0	10.5	-2.0	0.4	-3.0	-3.2	-2.2	-1.9	-1.9	-1.7	-3.1	-2.2	-1.8	-2.1	-2.4	1.2	-2.4	-2.5	-2.3
Whole body water mass	1.2	6.6	12.7	-2.1	2.5	-2.6	-1.9	-3.2	-2.7	-2.8	-3.1	-2.4	-2.8	-2.4	-2.6	-2.4	3.6	-2.2	-2.6	-0.8
Miserableness	1.2	2.0	4.2	-1.3	0.0	-1.9	-2.0	-0.9	-1.2	-1.2	-0.9	-1.0	-1.2	-1.0	-1.8	-1.8	0.2	-1.8	-1.8	-1.9
Ever taken oral contraceptive pill	1.2	1.3	2.7	-0.5	1.1	-0.6	-0.0	-1.5	-0.6	-1.6	-0.9	-0.8	-1.5	-0.9	-1.5	-1.3	1.6	-1.1	-1.3	-0.9
Arm fat-free mass (left)	1.2	6.0	14.4	-1.9	2.8	-2.5	-1.7	-3.0	-2.5	-3.1	-2.9	-2.1	-2.5	-2.3	-2.3	-2.0	3.8	-1.8	-2.3	-0.3
Major Depression (MDD)	1.1	1.4	6.2	-1.6	2.5	-0.6	0.2	-0.9	-1.1	-1.4	-0.7	-1.2	-0.4	-1.4	-0.4	-0.2	2.2	-0.3	-0.5	0.8
HbA1C	1.1	1.2	2.6	1.6	-0.7	0.3	-0.6	1.0	1.4	1.6	1.4	1.6	1.0	1.5	0.9	0.9	-1.0	0.9	1.0	0.5
Exposure to tobacco smoke at home	1.1	1.3	3.8	1.5	1.1	0.9	0.3	0.7	1.4	-0.2	0.8	1.1	1.0	1.7	1.0	1.1	0.8	1.3	1.1	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	9.3	-1.4	3.0	-1.1	-0.2	-1.0	-1.0	-0.9	-0.6	-1.0	-0.5	-1.2	-0.7	-0.4	2.6	-0.5	-0.7	1.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	4.3	-1.8	1.7	-0.9	-0.1	-1.4	-2.0	-1.4	-2.1	-1.0	-1.1	-1.9	-1.4	-1.1	0.9	-1.1	-1.0	0.7
Medication: Amlodipine	1.1	1.6	2.6	1.4	0.2	1.3	0.3	1.3	1.5	1.4	1.5	1.0	1.5	1.2	1.6	1.4	-1.3	1.3	1.5	0.9
Medication for pain relief, constipation, heartburn	1.1	1.9	3.3	1.7	-1.2	0.8	0.1	1.6	1.7	1.7	1.6	1.4	1.4	1.8	1.4	1.4	-0.9	1.5	1.5	0.3
Angina (self-reported)	1.1	1.5	2.3	-1.0	1.5	-1.2	-1.4	-1.2	-1.1	-1.4	-1.4	-0.7	-1.0	-1.2	-1.3	-1.4	1.4	-1.2	-1.3	-0.1
Age at last live birth	1.1	1.6	3.7	-1.3	0.3	-1.0	0.4	-1.3	-1.5	-1.9	-1.5	-1.1	-1.5	-1.6	-1.4	-1.2	0.9	-1.3	-1.4	-0.8
Hypertension (Self-reported)	1.1	3.1	7.2	2.2	-2.7	1.4	-0.3	1.7	2.3	1.9	2.2	0.8	1.3	2.3	1.8	1.3	-2.2	1.3	1.4	-0.9
Illnesses of siblings: Diabetes	1.1	1.3	4.5	0.4	1.2	0.3	0.0	1.6	0.9	1.9	1.0	0.9	1.7	0.7	0.9	1.0	0.3	1.0	1.0	2.1
Whole body fat-free mass	1.1	6.5	12.9	-2.0	2.5	-2.5	-1.9	-3.2	-2.7	-2.8	-3.1	-2.3	-2.7	-2.3	-2.6	-2.3	3.6	-2.1	-2.5	-0.7
Commuting to job workplace: Walk	1.1	1.2	2.7	-1.0	-0.7	-0.8	-1.4	-0.7	-1.3	0.4	-1.4	-1.4	-1.0	-1.1	-0.9	-1.0	-1.6	-1.1	-0.8	-1.1
Osteoarthritis (self-reported)	1.1	1.4	3.7	0.3	-0.1	0.3	-0.4	1.9	1.2	1.0	1.9	0.5	1.9	1.2	1.3	1.4	-1.0	1.3	1.4	0.7
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.9	-1.3	1.3	-1.7	-1.4	-1.5	-1.1	-1.0	-0.9	-1.5	-1.5	-1.0	-0.8	-1.0	0.9	-1.0	-1.1	-0.7
Basal metabolic rate	1.1	6.3	13.0	-1.9	2.4	-2.6	-2.0	-3.1	-2.6	-2.8	-2.9	-2.4	-2.6	-2.2	-2.5	-2.3	3.6	-2.1	-2.5	-0.7
Average weekly beer plus cider intake	1.1	1.5	2.7	1.6	-0.5	1.5	1.0	0.8	1.5	1.3	1.2	1.3	1.1	1.2	1.6	1.3	-1.2	1.2	1.3	0.8
Medication: Cholesterol lowering	1.0	1.6	3.6	1.7	-1.2	1.4	0.2	1.3	1.9	1.0	1.9	0.6	1.2	1.7	1.4	1.0	-1.2	1.0	1.1	-0.1
Breastfed as a baby	1.0	1.2	3.8	-1.9	0.7	-1.3	-1.3	-0.7	-1.4	-0.9	-1.1	-2.0	-0.6	-1.5	-0.7	-0.8	-0.3	-1.0	-0.7	-0.1
Glaucoma (self-reported)	1.0	1.2	5.9	-1.1	-0.9	-1.3	-2.4	-0.8	-0.7	-0.4	-1.0	-1.6	-1.0	-0.6	-0.6	-0.8	-1.0	-0.7	-0.5	-1.0
Arm fat-free mass (right)	1.0	4.9	12.0	-1.6	2.6	-2.2	-1.6	-2.8	-2.3	-2.7	-2.7	-2.0	-2.3	-2.1	-2.0	-1.8	3.5	-1.6	-2.0	-0.3
Knee pain experienced in last month	1.0	1.5	2.7	1.6	-0.1	1.2	1.5	0.8	1.4	0.1	1.1	1.1	1.2	1.6	1.6	1.6	0.5	1.6	1.4	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.6	1.6	0.7	0.1	0.2	0.8	1.5	0.6	1.2	1.1	1.0	1.2	1.0	1.1	1.6	1.2	0.9	1.3
Hearing aid user	1.0	1.1	3.1	1.2	-0.8	1.5	0.6	0.8	1.3	1.8	1.3	0.3	0.9	1.0	1.0	1.0	-0.6	1.1	1.1	1.1
Tinnitus: Yes, now most or all of the time	1.0	1.1	2.7	-0.2	0.0	-0.8	-0.6	-1.6	-0.8	-0.8	-1.1	-0.6	-1.6	-1.1	-1.3	-1.3	0.5	-1.2	-1.3	-1.5
Vascular/heart problems diagnosed by doctor	1.0	2.6	6.3	-2.0	2.5	-1.0	0.7	-1.6	-2.1	-1.7	-2.0	-0.9	-1.2	-2.1	-1.6	-1.1	2.2	-1.2	-1.3	0.7
Arm predicted mass (left)	1.0	5.1	12.4	-1.7	2.7	-2.3	-1.6	-2.8	-2.3	-2.9	-2.8	-1.9	-2.3	-2.1	-2.1	-1.8	3.5	-1.6	-2.0	-0.2
Angina	0.9	1.2	2.2	-0.9	1.2	-1.1	-1.5	-1.1	-1.0	-1.3	-1.3	-0.8	-0.9	-1.0	-1.3	-1.3	0.9	-1.2	-1.2	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.5	0.0	1.9	0.5	1.0	0.9	0.4	0.8	0.7	0.6	1.3	0.1	0.7	0.8	1.6	0.8	0.6	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	4.9	-0.2	1.8	0.6	1.9	0.1	0.1	-0.9	0.3	0.3	0.4	0.3	0.8	1.1	2.2	1.0	0.6	1.6
Medication: Allopurinol	0.9	1.2	2.7	-1.2	-0.2	-1.1	-1.6	-1.1	-1.0	-0.3	-0.9	-1.4	-1.1	-1.3	-1.1	-1.2	-0.6	-1.1	-1.0	-1.6
Whole body fat mass	0.9	3.6	6.1	-1.3	1.1	-2.3	-2.4	-2.3	-1.6	-2.0	-1.8	-2.5	-2.0	-1.4	-1.7	-1.8	2.3	-1.6	-2.0	-1.4
Number of full sisters	0.9	1.0	3.4	-1.0	1.7	-1.1	-0.2	-1.0	-1.2	-1.4	-1.0	-0.7	-0.8	-1.1	-0.6	-0.6	1.9	-0.7	-0.9	0.0
Illnesses of father: Heart disease	0.9	1.2	2.1	-1.2	1.1	-1.3	-1.2	-1.0	-1.3	-1.4	-1.3	-0.5	-1.0	-1.4	-1.2	-1.1	0.3	-1.1	-1.0	-0.3
Average weekly red wine intake	0.9	1.3	3.3	1.6	-0.5	0.8	0.8	0.9	1.5	1.0	1.1	1.0	1.2	1.8	1.3	1.3	0.6	1.4	1.2	0.7
Irritability	0.9	1.5	3.9	-1.9	2.0	-1.9	-1.8	-0.7	-0.9	-0.5	-0.7	-1.4	-0.5	-1.1	-1.1	-1.1	1.0	-1.1	-1.1	0.2
Crohns Disease (2017)	0.8	1.8	4.8	-1.5	0.7	-2.0	-2.2	-1.1	-1.4	-0.1	-1.4	-1.2	-0.9	-1.6	-1.5	-1.6	-0.7	-1.6	-1.3	-0.4
Lupus	0.8	1.2	3.4	0.1	0.7	1.1	0.4	1.0	0.1	0.4	0.0	0.3	1.0	0.6	1.5	1.6	-1.4	1.5	1.8	1.9
Waist Hip Ratio (WHR)	0.8	3.7	8.5	1.4	1.3	1.5	1.1	2.3	1.8	1.0	1.9	1.0	2.4	1.6	2.9	2.7	-0.8	2.4	2.5	2.5
Systolic blood pressure, automated reading	0.8	2.4	9.2	-0.0	-2.1	-1.5	-2.6	-0.6	-0.6	0.2	-1.1	-1.2	-1.5	-0.7	-1.2	-1.7	-1.5	-1.6	-1.5	-3.0
Medication: Co-codamol	0.8	1.0	2.6	1.0	0.2	0.2	-0.0	0.4	0.9	0.3	0.5	0.9	1.1	1.0	1.5	1.5	0.3	1.5	1.4	1.6
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.8	0.5	1.6	0.6	0.8	0.6	0.6	1.4	0.8	0.9	1.0	0.7	0.6	0.8	0.6	0.9	0.8	1.7
Trunk fat mass	0.8	3.5	5.9	-1.3	1.1	-2.3	-2.3	-2.2	-1.6	-2.0	-1.8	-2.3	-2.0	-1.4	-1.8	-1.8	2.4	-1.6	-2.0	-1.4
Trunk fat-free mass	0.8	4.3	11.2	-1.5	2.4	-2.0	-1.3	-2.8	-2.2	-2.3	-2.7	-1.7	-2.2	-1.9	-2.0	-1.8	3.4	-1.6	-2.0	-0.1
Hair/balding pattern: Pattern 3	0.8	1.2	2.3	1.2	-1.5	0.6	1.1	1.4	1.1	0.7	0.9	0.6	1.1	1.0	1.5	1.4	0.6	1.4	1.1	0.3
Happiness	0.8	1.0	3.1	-1.5	1.1	-1.4	-1.8	-0.7	-1.2	0.3	-0.6	-0.2	-0.7	-1.2	-1.1	-1.0	-0.4	-1.1	-0.8	0.4
Trunk predicted mass	0.8	4.7	11.8	-1.5	2.4	-2.1	-1.4	-2.9	-2.3	-2.4	-2.8	-1.8	-2.3	-2.0	-2.1	-1.9	3.4	-1.6	-2.0	-0.2
Tense / ‘highly strung’	0.8	1.3	2.2	0.7	-0.4	0.8	0.7	1.2	1.2	1.1	1.4	1.1	1.4	1.0	1.5	1.3	-1.1	1.2	1.4	1.3
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	4.7	2.2	0.3	1.3	0.2	0.4	1.3	0.8	0.5	1.1	0.5	1.6	1.1	1.0	0.3	1.1	1.0	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.6	-1.1	0.7	-0.9	-0.9	-1.1	-1.2	-0.8	-1.1	-0.9	-1.2	-1.3	-0.9	-1.0	0.0	-1.1	-0.9	-0.4
Arm predicted mass (right)	0.8	4.2	11.2	-1.5	2.4	-2.1	-1.6	-2.6	-2.1	-2.5	-2.5	-1.9	-2.1	-1.8	-1.9	-1.6	3.3	-1.4	-1.8	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	3.6	1.0	-0.5	1.3	1.3	1.1	1.1	1.9	1.3	1.9	1.6	1.2	1.3	1.4	-0.7	1.4	1.5	1.2
Ever had prostate specific antigen (PSA) test	0.8	0.9	4.9	0.4	2.0	0.4	1.0	0.1	0.3	-0.5	0.2	0.7	0.8	0.4	0.5	0.7	2.2	0.8	0.5	1.6
Age started oral contraceptive pill	0.8	1.0	2.2	-1.5	-0.3	-1.3	-1.4	-0.2	-1.2	-0.2	-0.9	-0.7	-0.6	-1.1	-1.2	-1.2	-1.3	-1.3	-0.9	-0.5
Pain experienced in last month	0.8	1.4	2.5	-0.6	1.2	-0.5	-0.2	-1.6	-1.4	-0.2	-1.6	-0.7	-1.4	-1.3	-1.4	-1.3	1.2	-1.3	-1.5	-0.9
Intelligence (Savage-Jansen 2018)	0.7	2.3	4.7	-2.0	0.1	-1.3	-1.1	-1.3	-1.7	-0.3	-1.2	-1.6	-1.2	-2.2	-1.9	-1.9	-0.3	-1.9	-1.7	-1.5
Sensitivity / hurt feelings	0.7	1.2	2.3	-1.5	0.9	-1.3	-1.3	-0.7	-1.2	-1.3	-1.2	-1.2	-0.9	-1.5	-1.1	-1.1	-0.2	-1.1	-1.0	-0.6
Father’s age at death	0.7	0.9	2.2	1.1	-0.2	0.8	0.4	0.5	1.2	0.6	0.9	0.4	0.9	1.5	1.3	1.3	0.1	1.3	1.2	1.2
Worrier / anxious feelings	0.7	1.3	2.9	-1.6	0.7	-1.7	-1.2	-0.9	-1.1	-1.4	-0.6	-1.0	-1.1	-1.5	-1.2	-1.2	0.2	-1.3	-1.2	-0.7
Neck or shoulder pain in last month	0.7	1.0	2.0	-0.9	-0.4	-1.4	-1.3	-0.9	-0.6	-1.3	-0.5	-0.4	-1.2	-0.7	-1.4	-1.3	-0.2	-1.2	-1.1	-1.0
Mean time to correctly identify matches	0.7	1.4	3.9	-1.3	1.7	-0.4	-1.0	-1.4	-1.7	-0.2	-2.0	-1.7	-1.2	-1.3	-0.8	-0.8	-0.2	-0.9	-0.6	0.6
Leg fat mass (right)	0.7	2.6	4.5	-1.0	1.3	-2.0	-2.0	-2.1	-1.3	-1.9	-1.5	-2.0	-1.8	-1.1	-1.3	-1.4	2.1	-1.2	-1.6	-1.1
Long-standing illness, disability or infirmity	0.7	1.0	2.9	-1.0	0.7	-1.5	-1.7	-0.7	-0.7	-0.7	-0.3	-1.2	-0.9	-1.0	-0.9	-1.1	0.2	-1.1	-1.1	-1.0
Medication: Aspirin	0.7	0.9	2.8	-0.8	-1.3	-1.3	-1.7	0.2	-0.3	-0.9	-0.1	-1.0	-0.5	-0.9	-0.5	-0.8	-1.3	-0.9	-0.8	-1.3
Financial situation satisfaction	0.7	0.8	3.9	-0.7	0.9	-0.1	0.9	-1.1	-0.8	-1.2	-0.7	-0.7	-0.9	-0.5	-0.6	-0.7	2.0	-0.8	-1.0	-0.2
Medication: Bendroflumethiazide	0.7	1.0	4.3	1.0	-2.1	0.5	-0.1	1.0	1.3	0.5	1.6	0.2	0.6	1.1	0.9	0.6	-1.0	0.5	0.5	-1.3
Medication: Paracetamol	0.7	1.2	3.8	-1.1	1.5	-0.7	0.2	-0.8	-1.3	-1.1	-0.9	-1.2	-0.9	-1.2	-1.0	-0.9	1.9	-1.0	-1.2	-0.2
Leg fat mass (left)	0.7	2.8	5.0	-1.0	1.2	-2.0	-1.9	-2.2	-1.4	-2.0	-1.6	-2.0	-1.9	-1.1	-1.4	-1.4	2.2	-1.3	-1.7	-1.2
Lung FVC	0.6	3.3	5.2	1.4	-1.0	1.9	1.1	1.7	1.4	2.3	1.4	1.9	2.2	1.4	1.9	2.0	-2.1	2.0	2.3	1.9
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.7	0.6	-0.9	0.7	-0.3	1.1	0.9	1.3	1.1	0.3	0.7	1.1	0.7	0.7	-1.3	0.6	0.8	0.0
Trunk fat percentage	0.6	2.3	4.3	-1.1	0.4	-2.0	-2.1	-1.6	-1.2	-1.5	-1.2	-2.0	-1.5	-1.0	-1.4	-1.5	1.7	-1.4	-1.6	-1.5
Hearing difficulty/problems with background noise	0.6	0.9	2.3	-0.7	1.5	-0.8	-0.7	-1.4	-1.0	-0.6	-1.0	-1.0	-0.9	-0.9	-0.9	-0.9	1.1	-0.9	-1.0	0.2
Pain all over the body in last month	0.6	0.6	2.6	0.3	-0.9	-0.2	-1.6	0.8	0.8	0.9	1.0	-0.5	0.4	0.7	0.2	0.0	-1.6	0.1	0.3	-0.5
Diabetes (self-reported)	0.6	1.0	2.6	1.6	-1.2	0.6	-0.7	0.9	1.4	1.6	1.3	0.1	0.9	1.3	0.8	0.3	-1.0	0.3	0.4	-0.5
Neuroticism score	0.6	1.2	3.9	-2.0	1.3	-1.5	-1.0	-0.7	-1.1	-1.4	-0.5	-1.4	-0.7	-1.3	-1.0	-1.0	0.3	-1.1	-1.0	-0.2
Number of live births	0.6	0.8	3.8	-0.8	0.1	-1.5	-1.9	-0.1	-0.6	0.5	-0.1	-1.0	-0.5	-0.8	-0.8	-0.8	-0.1	-0.9	-0.9	-1.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.9	1.6	0.8	1.0	1.0	0.5	0.9	-0.2	0.5	1.1	1.3	1.2	1.4	1.3	0.8	1.2	1.1	1.7
High blood pressure (siblings)	0.6	0.9	1.8	1.0	-0.5	1.1	1.3	0.6	1.0	1.0	1.1	1.1	0.8	0.6	1.0	1.0	-0.2	0.9	1.0	0.8
Forced vital capacity (FVC), Best measure	0.6	2.1	5.1	1.5	0.0	1.9	2.2	0.8	0.9	1.6	0.7	2.0	1.5	1.0	1.2	1.6	0.8	1.7	1.5	1.8
Medication: Omeprazole	0.6	0.7	2.1	-0.9	0.5	-0.7	-0.5	-1.0	-1.2	-0.3	-1.2	-0.5	-0.7	-1.5	-1.0	-0.9	0.7	-0.8	-0.8	-0.3
Mood swings	0.6	1.1	6.1	-1.2	2.5	-1.1	-0.7	-0.8	-0.8	-1.1	-0.7	-0.7	-0.5	-1.0	-0.7	-0.6	1.5	-0.6	-0.7	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	4.0	0.1	2.0	-0.5	0.1	-1.0	-0.3	-0.3	-0.7	-0.0	-0.2	-0.2	0.4	0.4	1.5	0.4	0.2	1.4
Asthma (self-reported)	0.6	1.1	3.5	-0.5	0.4	-0.9	-1.9	-0.6	-0.7	-0.3	-0.3	-1.4	-0.9	-0.8	-1.0	-1.4	-0.6	-1.6	-1.4	-1.6
Number of operations (self-reported)	0.6	0.8	1.9	0.3	-0.8	0.4	0.2	1.4	1.1	0.6	1.1	-0.4	1.3	1.1	1.1	1.1	-0.6	1.1	1.1	0.7
Fractured/broken bones in last 5 years	0.6	0.7	1.2	1.0	-0.3	0.6	0.8	0.8	1.0	0.7	0.9	1.0	0.9	0.5	1.0	1.1	-0.5	1.1	1.1	0.5
Worry (Nagel 2018)	0.5	1.0	1.9	0.5	0.3	0.4	0.6	1.1	1.1	0.6	1.3	1.0	1.2	0.9	1.3	1.2	-1.0	1.0	1.2	1.4
Bipolar Disorder (2011)	0.5	0.5	1.4	-1.2	0.8	-1.1	-0.8	0.3	-0.9	-0.2	-0.5	-0.3	0.0	-0.9	-0.7	-0.4	0.9	-0.5	-0.5	0.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.9	0.2	-1.7	-0.1	-1.5	0.2	-0.3	-0.3	-0.1	-0.6	-0.3	-0.2	-0.1	-0.3	-1.7	-0.4	-0.2	-1.2
Systolic Blood Pressure	0.5	2.3	8.6	0.2	-2.8	-1.1	-2.6	-0.6	-0.2	0.5	-0.9	-0.9	-1.2	-0.1	-0.8	-1.3	-2.5	-1.1	-0.9	-2.9
Hypothyroidism (self reported)	0.5	1.1	2.3	1.5	0.4	0.9	0.3	0.9	1.1	0.2	0.8	0.8	1.4	1.3	1.4	1.3	-0.3	1.1	1.2	1.3
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.3	-0.9	1.1	-0.1	0.4	-1.1	-0.9	-0.4	-0.7	-0.6	-1.0	-0.9	-0.9	-0.8	0.9	-0.7	-0.8	-0.2
Relative age of first facial hair	0.5	1.0	2.5	0.3	0.4	1.5	0.7	0.7	0.8	1.6	0.9	0.8	0.9	0.8	1.0	1.0	-1.3	0.9	1.2	1.4
Townsend deprivation index at recruitment	0.5	0.8	3.6	-0.5	1.9	-0.2	0.6	-1.1	-1.0	-1.0	-1.0	0.1	-0.7	-0.8	-0.5	-0.4	1.4	-0.4	-0.5	0.6
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.8	0.1	-0.3	-1.2	-1.2	-0.9	-0.3	-1.3	-0.5	-0.3	-0.8	-0.6	-0.6	-0.8	1.0	-0.7	-0.9	-1.0
Impedance of arm (right)	0.5	2.3	8.2	1.3	-2.9	1.3	0.7	1.9	1.5	1.9	1.7	1.4	1.4	1.4	0.7	0.6	-2.5	0.6	0.9	-0.6
Lung cancer (father)	0.5	0.6	1.2	0.5	0.2	1.1	1.1	0.2	0.3	0.4	0.3	0.8	0.9	0.2	1.0	1.1	-0.8	1.0	1.1	1.0
Impedance of arm (left)	0.5	2.5	5.3	1.4	-2.3	1.2	0.6	2.2	1.7	2.2	2.0	1.7	1.9	1.5	1.0	0.9	-2.1	1.0	1.2	0.1
Length of working week for main job	0.5	0.6	1.5	0.5	-0.2	-0.1	0.4	-1.2	-0.3	-1.0	-0.4	0.1	-1.0	-0.0	-0.9	-0.9	0.9	-0.8	-0.9	-1.2
Ever highly irritable/argumentative for 2 days	0.5	0.7	2.1	0.0	1.2	-0.8	-0.7	-1.0	-0.4	-1.0	-0.6	-0.3	-0.8	-0.3	-0.8	-0.9	1.4	-0.8	-1.0	-0.5
Medication: Paracetamol	0.5	0.9	4.0	-1.0	2.0	-0.1	0.6	-0.8	-1.0	-0.5	-0.9	-0.9	-0.7	-1.1	-0.6	-0.5	1.6	-0.6	-0.7	0.5
Body fat percentage	0.5	2.0	4.8	-0.9	0.5	-1.9	-2.2	-1.5	-1.0	-1.4	-1.0	-2.1	-1.4	-0.9	-1.2	-1.3	1.4	-1.2	-1.4	-1.4
Heart disease (mother)	0.5	0.6	1.7	0.4	-0.4	0.1	0.2	1.2	0.6	0.3	0.7	0.9	1.3	0.4	0.8	0.9	-0.3	0.9	1.0	1.0
Medication: Aspirin	0.5	0.7	3.0	-0.9	-1.0	-1.2	-1.7	0.4	-0.2	-0.6	-0.0	-0.9	-0.2	-0.7	-0.3	-0.6	-1.3	-0.7	-0.5	-0.8
Medication for cholesterol	0.5	0.7	2.2	-1.0	0.4	-1.0	-0.3	-0.9	-1.1	-0.9	-1.0	-0.8	-0.7	-1.5	-0.8	-0.7	0.9	-0.7	-0.8	-0.4
Depression (Nagel 2018)	0.4	0.6	2.3	-0.7	1.5	-0.8	-0.4	-0.9	-0.8	-0.8	-0.7	-0.2	-0.5	-0.9	-0.8	-0.7	0.6	-0.8	-0.7	0.2
Schizophrenia vs Biploar Disorder	0.4	0.5	2.3	-0.0	-1.0	-0.7	-0.7	-0.9	-0.1	-1.5	-0.5	-0.8	-1.0	0.2	-0.3	-0.5	0.2	-0.5	-0.5	-0.3
Ever had hysterectomy (womb removed)	0.4	0.4	1.9	-0.5	-0.8	-0.3	-0.9	0.3	-0.0	1.2	0.2	-0.9	0.0	-0.1	-0.3	-0.4	-1.4	-0.4	-0.2	-0.4
Medication: Metformin	0.4	0.5	2.1	0.7	-0.9	-0.2	-1.1	0.1	0.7	0.2	0.7	-0.9	-0.0	0.5	0.2	-0.3	-1.4	-0.4	-0.3	-1.2
Severe depression (siblings)	0.4	0.4	3.2	-0.3	1.8	-0.2	-0.5	-0.1	-0.0	0.4	-0.1	-0.1	0.1	-0.1	-0.3	-0.1	1.2	0.1	-0.0	1.2
Maternal smoking around birth	0.4	0.6	1.5	0.9	-1.2	1.1	0.5	0.5	1.0	-0.2	1.1	-0.4	-0.0	0.8	0.4	0.3	-1.2	0.3	0.3	-1.1
Relative age voice broke	0.4	0.6	2.8	0.2	1.7	1.2	1.3	-0.5	-0.2	0.5	-0.3	0.2	0.1	-0.0	0.5	0.5	0.8	0.4	0.4	1.5
Qualifications: CSEs or equivalent	0.4	0.5	3.2	0.1	-0.1	-1.4	-0.3	-1.0	-0.2	-1.0	-0.4	0.3	-0.5	-0.3	-0.3	-0.2	1.8	-0.2	-0.4	0.3
Forced vital capacity (FVC)	0.4	1.7	3.6	1.5	-0.3	1.7	1.9	0.8	1.1	0.7	0.7	1.7	1.5	1.0	1.1	1.4	1.1	1.6	1.3	1.7
Financial difficulties in last 2 years	0.4	0.6	2.1	-0.9	1.5	-0.6	-0.2	-0.8	-0.6	-1.0	-0.9	-0.8	-0.4	-0.6	-0.2	-0.3	1.2	-0.4	-0.4	0.7
Illnesses of siblings	0.4	0.6	2.6	-0.0	-0.5	-0.4	-0.9	-0.5	-0.4	-1.2	-0.4	-0.5	-0.8	-0.1	-0.8	-0.9	-0.4	-0.8	-0.9	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	4.5	-0.8	2.1	-0.6	-0.1	-0.7	-0.9	-0.7	-0.4	0.2	-0.7	-0.9	-0.6	-0.5	1.2	-0.6	-0.7	0.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.6	1.6	-0.9	1.4	1.0	1.0	1.2	1.0	0.9	1.6	1.3	1.2	0.8	1.1	0.4	1.3	1.1	1.2
Asthma	0.4	0.8	2.8	-0.4	0.4	-0.7	-1.7	-0.4	-0.5	0.1	-0.1	-1.2	-0.6	-0.6	-0.8	-1.2	-0.8	-1.5	-1.2	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.9	1.4	-0.5	1.4	1.2	0.6	0.9	1.7	0.6	1.7	1.0	1.1	0.7	1.0	0.3	1.2	1.1	1.1
Headache pain in last month	0.4	0.8	1.7	-1.3	-0.9	-0.5	-0.0	-0.5	-1.0	-1.0	-1.1	-0.7	-1.0	-1.1	-0.6	-0.6	-1.1	-0.7	-0.6	-1.1
Gout (self-reported)	0.4	0.5	1.1	-0.5	-0.3	-0.9	-1.0	-0.8	-0.6	-0.8	-0.6	-0.9	-0.7	-0.7	-0.6	-0.7	0.4	-0.6	-0.7	-1.1
Wheeze or whistling in the chest in last year	0.4	0.8	2.2	-0.7	0.9	-1.3	-1.5	-1.0	-0.5	-0.4	-0.1	-0.7	-0.6	-0.3	-0.8	-1.1	0.1	-1.3	-1.2	-0.9
Pulse wave peak to peak time	0.4	0.5	3.8	-0.8	1.2	-0.4	0.8	-0.4	-0.5	-0.1	-0.6	0.2	-0.2	-0.3	-0.3	-0.1	1.9	-0.0	-0.3	1.0
Medication: Blood pressure	0.4	0.7	2.5	0.7	-1.6	0.1	-0.9	0.7	1.0	0.9	1.1	-0.2	0.3	1.0	0.8	0.4	-1.3	0.4	0.4	-1.1
Suffer from ‘nerves’	0.4	0.6	1.1	0.6	0.5	0.9	0.4	0.5	0.8	1.0	1.0	0.9	0.6	0.8	0.5	0.5	-1.0	0.5	0.7	0.9
Chest pain or discomfort	0.4	0.6	1.6	0.6	-0.4	0.5	1.1	0.5	0.9	-0.2	1.0	0.6	0.5	0.9	1.3	1.0	-0.2	0.9	0.8	-0.0
Leg pain on walking	0.4	0.5	2.4	-0.3	1.2	0.9	1.0	-0.4	-0.6	0.4	-0.3	0.1	0.3	-0.3	0.6	0.6	-0.3	0.5	0.6	1.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.6	0.8	-1.6	0.4	0.4	-0.2	0.1	0.3	0.1	0.6	-0.4	0.2	-0.3	-0.4	-0.7	-0.4	-0.4	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.6	-1.0	1.1	-0.0	0.7	-0.6	-0.8	-0.5	-1.0	-0.2	-0.4	-1.3	-0.3	-0.2	1.1	-0.1	-0.2	0.3
Diabetes diagnosed by doctor	0.4	0.7	1.9	1.3	-0.9	0.1	-1.0	0.8	1.2	0.9	1.4	0.0	0.8	1.2	0.5	0.1	-1.1	0.1	0.2	-0.7
Number of self-reported non-cancer illnesses	0.4	0.6	1.5	1.1	-1.2	-0.3	-1.0	0.4	1.1	1.0	1.1	0.3	0.5	1.2	0.7	0.4	-0.7	0.3	0.4	-0.2
Mother’s age at death	0.4	0.5	1.2	0.7	-0.9	1.1	0.5	0.5	0.8	0.4	0.8	0.5	0.5	1.1	0.8	0.8	-0.4	0.9	0.8	0.0
Eye problems/disorders: Glaucoma	0.4	0.5	2.4	-0.6	-0.4	-1.1	-1.5	-0.7	-0.6	-0.4	-0.9	-0.6	-0.8	-0.2	-0.6	-0.6	-0.0	-0.4	-0.4	-0.5
Medication: Atorvastatin	0.4	0.5	4.6	0.4	-2.2	0.2	-0.1	0.4	0.6	0.3	0.8	-0.3	0.3	0.1	0.2	0.1	-1.4	0.1	0.2	-0.8
Alcohol drinker status: Never	0.4	0.5	1.5	-0.6	1.2	-0.9	-1.2	-0.6	-0.9	-0.5	-1.0	-0.2	-0.5	-0.8	-0.6	-0.6	0.2	-0.6	-0.5	-0.4
Risk taking	0.4	0.6	2.7	1.6	0.4	1.1	1.4	-0.9	0.2	-0.1	-0.5	0.8	-0.5	0.3	0.0	-0.1	1.1	-0.0	-0.2	0.3
Supplements: Calcium	0.4	0.5	2.7	-1.3	1.3	-0.5	-0.4	0.2	-0.5	0.5	-0.0	-0.6	0.1	-0.5	-0.3	0.0	0.2	-0.0	0.1	1.6
Pack years of smoking	0.4	0.6	3.1	1.1	-0.1	1.1	0.6	0.7	0.3	1.1	0.1	1.7	0.6	0.6	0.4	0.5	-0.4	0.6	0.6	0.9
Irritable Bowel Disease (IBD)	0.3	0.6	2.1	0.6	0.1	-0.2	-1.0	0.4	0.6	1.4	0.6	0.6	1.2	0.6	0.5	0.4	-1.0	0.3	0.6	1.4
Triglycerides	0.3	0.5	2.1	1.2	-0.3	0.6	0.4	0.5	0.7	0.5	0.5	1.5	0.5	0.8	0.8	0.7	-0.1	0.7	0.6	0.1
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.3	0.4	-0.7	-0.7	-1.5	-0.1	0.3	0.2	0.4	-0.5	0.0	0.6	-0.5	-0.8	-0.9	-0.8	-0.7	-1.0
Neuroticism	0.3	0.7	2.2	-1.4	1.2	-1.3	-1.5	0.1	-0.6	-1.0	-0.1	-1.2	-0.0	-0.9	-0.4	-0.4	-0.4	-0.6	-0.4	-0.2
Hand grip strength (left)	0.3	0.8	1.7	1.3	-0.8	1.0	1.3	0.2	1.0	0.9	0.7	1.3	0.7	1.0	0.6	0.8	0.6	0.9	0.7	0.4
Diabetes (mother)	0.3	0.4	2.5	-1.0	1.6	-0.1	-0.2	-0.4	-0.2	-0.4	-0.5	-0.7	-0.2	-0.0	-0.1	0.0	0.6	0.1	0.0	1.2
Hand grip strength (right)	0.3	0.7	1.5	1.1	-1.2	0.8	1.1	0.4	1.1	0.5	1.0	1.2	0.6	1.1	0.4	0.5	0.1	0.7	0.5	-0.2
Had other major operations	0.3	0.4	2.9	-1.0	0.4	-0.5	-0.9	-0.1	-0.6	-0.4	-0.4	-1.7	-0.3	-0.4	-0.1	-0.2	-0.2	-0.3	-0.2	-0.3
Pulse wave Arterial Stiffness index	0.3	0.3	2.0	0.9	-0.9	0.3	-0.6	0.2	0.4	-0.1	0.4	-0.1	0.1	0.3	0.2	0.1	-1.4	0.0	0.2	-0.8
Birth weight of first child	0.3	0.5	3.3	-0.1	0.9	0.9	1.0	-0.0	0.1	0.3	-0.3	-0.1	0.5	0.1	0.5	0.8	0.4	0.8	0.8	1.8
Shortness of breath walking on level ground	0.3	0.4	2.1	-0.5	1.4	-0.1	0.3	-0.8	-0.9	0.1	-0.6	-0.3	-0.6	-0.7	-0.2	-0.3	1.0	-0.4	-0.5	0.0
Ever had bowel cancer screening	0.3	0.3	1.0	-1.0	0.5	-0.6	-0.3	-0.4	-1.0	-0.4	-0.9	-1.0	-0.4	-0.5	-0.1	-0.1	0.1	-0.1	-0.1	-0.5
Eye problems/disorders: Cataract	0.3	0.3	2.1	-0.8	-1.4	0.0	-0.2	0.5	-0.3	0.1	0.1	-0.6	-0.1	-0.4	-0.4	-0.4	-1.0	-0.3	-0.2	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.9	-0.0	-1.7	-0.3	-0.8	-0.7	0.3	-0.4	-0.0	-0.7	-1.0	0.2	-0.2	-0.3	-1.2	-0.2	-0.1	-1.0
Mineral and other dietary supplements	0.3	0.4	1.3	1.1	-1.1	0.1	-0.6	0.5	0.7	0.7	0.2	0.4	0.2	0.6	0.8	0.5	-0.9	0.4	0.5	-0.4
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.3	-1.0	1.1	-0.0	0.8	-0.4	-0.6	-0.3	-0.1	-0.2	-0.2	-0.7	-0.7	-0.5	1.0	-0.5	-0.5	0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.3	-0.8	0.1	-0.6	-0.5	-0.5	-1.0	0.1	-0.7	-0.2	-0.3	-1.1	-0.8	-0.7	0.0	-0.8	-0.7	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.0	0.5	0.3	-0.4	-1.0	0.7	0.6	0.9	0.8	0.0	0.9	0.5	0.4	0.4	0.3	0.5	0.5	0.7
Neuroticism (Nagel 2018)	0.2	0.4	0.9	0.2	0.8	-0.2	-0.5	0.8	0.5	0.1	0.6	0.6	0.9	0.4	0.6	0.6	-0.7	0.5	0.6	0.9
Alzheimer’s Disease (including proxy)	0.2	0.3	1.2	0.2	-1.1	0.8	0.8	0.0	0.2	1.0	0.3	0.0	0.0	0.0	0.3	0.2	-0.9	0.2	0.2	-0.9
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.0	-0.8	0.1	-0.1	0.2	-0.5	-0.6	0.2	-0.4	-0.7	-0.6	-1.0	-0.7	-0.6	-0.4	-0.7	-0.5	-0.9
Breast Cancer	0.2	0.4	1.7	0.1	-0.9	0.1	-0.2	0.0	0.0	0.1	0.0	-0.8	-0.3	0.1	0.9	0.8	-1.3	0.6	0.6	-1.3
Mean Putamen Volume	0.2	0.2	1.0	-0.1	-0.1	0.6	0.6	0.6	0.2	1.0	0.3	0.4	0.6	0.1	0.1	0.3	-0.2	0.4	0.4	0.7
Fasting Glucose	0.2	0.3	1.4	0.3	0.2	0.8	0.6	0.5	0.4	1.2	0.5	0.4	0.5	0.3	0.4	0.4	-0.2	0.4	0.4	0.3
LDL Cholesterol	0.2	0.3	1.0	0.2	-0.1	-0.4	-0.4	-0.4	-0.3	0.3	-0.1	0.6	-0.2	-0.2	-1.0	-1.0	0.1	-1.0	-0.9	-0.6
Neuroticism (2016)	0.2	0.3	1.2	-0.6	-0.7	-0.5	-1.1	-0.1	-0.2	-0.4	0.0	-0.6	-0.4	-0.6	-0.8	-0.7	-0.0	-0.6	-0.6	-0.6
Rheumatoid Arthritis	0.2	0.2	0.7	0.2	0.8	0.6	0.4	0.6	0.7	0.6	0.7	0.4	0.3	0.3	0.0	0.2	0.2	0.3	0.3	0.8
Blood Red Count	0.2	2.0	8.9	-0.8	-1.5	-1.4	-1.4	-1.3	-1.2	-0.5	-1.1	-0.9	-1.7	-0.8	-1.2	-1.5	-1.1	-1.5	-1.4	-3.0
Blood White Count	0.2	1.2	4.6	-0.9	-0.3	-0.9	-0.1	-1.3	-0.9	-1.0	-0.4	-0.7	-1.7	-1.0	-0.9	-1.1	0.4	-1.2	-1.3	-2.1
Height	0.2	3.7	10.4	-1.2	1.9	-1.5	-0.6	-1.9	-2.6	-1.4	-3.2	-0.7	-1.6	-2.5	-2.3	-1.6	3.2	-1.3	-1.6	0.5
Smoking Status	0.2	0.4	1.5	-0.4	0.5	-1.2	-0.9	-0.8	-0.4	-1.2	0.0	-0.3	-0.4	-0.5	-0.3	-0.4	0.5	-0.5	-0.5	-0.0
Medication for hormone replacement therapy	0.2	0.3	1.2	-1.0	0.5	0.0	-0.3	-0.1	-0.2	0.6	0.1	-1.1	-0.2	0.1	-0.7	-0.6	0.0	-0.6	-0.5	0.4
Fed-up feelings	0.2	0.3	1.2	-0.3	1.1	-0.5	0.2	-0.6	-0.4	-1.1	-0.3	0.1	-0.3	-0.2	-0.2	-0.1	1.0	-0.2	-0.4	0.3
Taking other prescription medications	0.2	0.4	2.4	0.2	-0.6	-0.8	-1.6	0.4	0.2	0.2	0.5	-0.4	0.2	-0.1	-0.0	-0.3	-1.3	-0.5	-0.3	-0.6
Medication: Atenolol	0.2	0.3	0.7	-0.4	-0.6	-0.4	-0.5	-0.7	-0.4	-0.3	-0.4	-0.7	-0.8	-0.4	-0.4	-0.5	-0.5	-0.4	-0.4	-0.8
Medication: Levothyroxine sodium	0.2	0.4	2.5	0.4	0.4	-0.2	0.5	-0.7	-0.3	-1.6	-0.8	-0.2	-0.4	0.0	0.1	-0.0	1.2	-0.1	-0.3	-0.3
Hair/balding pattern: Pattern 2	0.2	0.3	1.2	0.5	-0.2	0.0	0.3	0.7	0.7	0.4	1.1	0.7	0.8	0.7	0.3	0.4	-0.2	0.4	0.4	0.4
Fluid intelligence score	0.2	0.4	2.3	-0.0	-1.5	0.1	0.2	0.4	0.1	1.1	0.3	0.1	0.0	-0.2	-0.2	-0.3	-1.1	-0.3	-0.1	-1.2
Time employed in main current job	0.2	0.3	1.2	0.2	-1.1	0.0	-0.7	-0.0	0.1	-0.5	-0.3	-1.1	-0.5	0.0	0.3	0.2	-0.7	0.2	0.2	-0.8
Alcohol intake versus 10 years previously	0.2	0.2	0.9	0.9	0.4	0.7	0.6	-0.4	0.4	-0.6	0.0	0.1	0.1	0.3	0.7	0.4	0.5	0.3	0.3	0.4
Falls in the last year	0.2	0.2	0.9	-0.4	0.9	-0.4	-0.4	-0.4	-0.2	-0.4	-0.3	-0.9	-0.4	-0.4	-0.3	-0.5	0.3	-0.5	-0.5	-0.0
Noisy workplace	0.2	0.3	1.5	0.2	0.7	0.2	0.9	-0.6	-0.2	0.0	-0.5	0.3	-0.6	-0.3	-0.0	-0.1	1.2	-0.1	-0.3	-0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.5	4.1	-0.6	-1.1	0.1	-0.6	0.4	-0.4	0.8	-0.1	-0.8	0.4	-0.7	0.2	0.2	-2.0	0.0	0.4	-0.0
Depression (self-reported)	0.2	0.2	0.9	-0.7	-0.2	-0.9	-0.8	-0.7	-0.4	-0.1	-0.3	-0.7	-0.5	-0.4	-0.4	-0.4	0.1	-0.4	-0.4	0.1
Pulse wave reflection index	0.2	0.3	0.7	0.6	-0.1	0.5	0.5	-0.0	0.6	-0.3	0.6	0.3	0.4	0.6	0.8	0.8	0.1	0.8	0.7	0.3
Blood clot in the leg (DVT)	0.2	0.3	0.9	0.5	0.4	-0.3	-0.8	0.6	0.5	1.0	0.7	0.1	0.7	0.4	0.3	0.3	0.3	0.4	0.4	0.5
Leg fat percentage (right)	0.2	0.8	2.6	-0.2	0.9	-1.3	-1.6	-1.1	-0.3	-1.0	-0.4	-1.3	-0.8	-0.2	-0.3	-0.5	1.3	-0.4	-0.7	-0.7
Worry too long after embarrassment	0.2	0.4	1.6	-0.4	1.3	0.1	-0.1	1.0	0.6	-0.3	0.9	0.1	0.9	0.3	0.3	0.4	-0.1	0.4	0.5	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	0.4	0.4	0.4	0.5	-0.2	0.2	-0.7	-0.2	0.1	0.2	0.2	0.5	0.5	0.3	0.5	0.4	0.7
Age at first live birth	0.2	0.4	2.1	-0.6	-0.1	-0.4	0.8	-0.4	-0.7	-1.4	-0.9	-0.3	-0.6	-0.5	-0.3	-0.2	0.8	-0.2	-0.3	0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.7	-0.8	-0.3	-0.1	-0.4	-0.4	-0.5	-0.3	-0.4	-0.8	-0.6	-0.1	-0.2	-0.3	-0.8	-0.3	-0.2	-0.7
Emphysema/chronic bronchitis	0.2	0.3	1.8	-0.4	-0.4	-0.0	-0.3	0.4	-0.2	-0.9	-0.1	-0.6	-0.1	-0.5	-0.2	-0.3	-1.4	-0.5	-0.2	-0.4
Comparative height size at age 10	0.2	1.3	3.0	-0.8	0.7	-1.5	-1.7	-0.8	-1.3	-0.9	-1.3	-1.0	-0.7	-1.4	-1.6	-1.2	1.0	-1.0	-1.1	-0.2
Overall health rating	0.2	0.5	3.5	-0.7	1.9	-0.4	-0.3	-0.7	-0.9	-0.8	-0.7	-0.6	-0.4	-1.0	-0.1	-0.2	0.7	-0.4	-0.4	-0.0
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.3	0.1	0.1	-0.3	-0.5	-0.4	-0.4	-1.1	-0.9	-0.3	-0.6	-0.3	-0.6	-0.4	0.7	-0.3	-0.4	-0.3
Medication: Gliclazide	0.2	0.2	1.1	0.5	-0.5	0.5	0.1	0.2	0.2	0.9	0.2	0.3	0.2	0.1	0.4	0.3	-1.1	0.2	0.3	-0.1
Medication: Lisinopril	0.2	0.2	1.3	0.6	-0.8	0.2	-0.3	0.6	0.2	0.6	0.1	0.2	0.1	0.3	-0.1	-0.2	-0.7	-0.1	-0.1	-1.1
Leg fat percentage (left)	0.2	0.9	2.4	-0.3	0.7	-1.4	-1.6	-1.2	-0.5	-1.1	-0.6	-1.4	-1.1	-0.3	-0.5	-0.6	1.3	-0.6	-0.8	-0.8
Unable to work because of sickness or disability	0.2	0.3	1.4	0.2	1.2	-0.2	-0.6	0.2	0.3	0.9	0.2	-0.1	0.6	0.6	0.4	0.3	0.3	0.3	0.3	1.0
Alcohol drinker status: Previous	0.2	0.3	1.1	0.7	0.1	0.2	1.1	-0.4	0.2	-0.1	-0.3	0.6	-0.4	0.5	0.3	0.3	1.1	0.4	0.1	0.1
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	0.4	-0.0	-0.1	-0.7	0.7	0.6	0.3	0.7	0.5	0.6	0.5	0.2	0.2	-0.8	0.2	0.3	0.0
HDL Cholesterol	0.1	0.2	1.0	0.5	-1.0	-0.1	0.3	0.1	0.5	-0.5	0.6	-0.1	0.2	0.6	0.1	0.0	0.2	0.1	-0.0	-0.3
Primary Biliary Cirrhosis	0.1	0.2	1.3	0.0	0.6	0.2	-0.0	0.3	-0.0	1.1	-0.2	-0.1	0.5	-0.1	0.6	0.4	-0.2	0.2	0.4	0.9
Respiratory disease	0.1	0.3	1.4	0.4	-0.5	-0.2	-1.0	0.4	0.2	0.3	0.7	-0.2	0.1	0.1	0.1	-0.3	-1.2	-0.5	-0.3	-0.9
Lung FEV1/FVC ratio	0.1	0.5	4.2	-0.0	-0.5	-1.1	-2.0	0.6	0.4	0.8	0.4	0.2	0.2	0.4	-0.6	-0.5	-0.7	-0.4	-0.2	-0.1
Hair Pigment	0.1	2.8	3.9	-1.9	0.8	-1.6	-0.5	-1.9	-1.9	-1.7	-1.8	-1.6	-2.0	-1.7	-1.8	-1.8	1.6	-1.9	-1.9	-0.9
Number of treatments/medications taken	0.1	0.2	0.5	0.1	-0.5	-0.2	-0.7	0.1	0.2	-0.0	0.5	-0.3	-0.1	0.2	-0.2	-0.4	-0.7	-0.5	-0.4	-0.6
Hearing difficulty/problems: Yes	0.1	0.1	0.5	0.3	-0.4	0.3	-0.4	0.0	0.7	0.1	0.7	-0.2	-0.1	0.7	-0.0	-0.0	-0.4	0.1	0.2	0.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	-0.5	0.5	-0.2	-0.5	-0.0	-0.4	-0.0	-0.0	-0.6	-0.3	-0.7	-0.3	-0.4	0.1	-0.5	-0.5	-0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.5	-0.2	0.7	0.2	0.1	-0.3	-0.5	-0.1	-0.6	-0.0	-0.0	-0.5	0.1	-0.1	0.3	-0.1	-0.2	-0.1
Diabetes (father)	0.1	0.1	0.5	0.2	-0.6	0.1	0.6	0.2	0.3	0.7	0.3	0.7	-0.0	0.4	-0.2	-0.1	0.0	-0.0	-0.0	-0.4
Pack years adult smoking proportion	0.1	0.2	1.7	0.7	0.4	0.6	0.3	-0.0	-0.3	0.5	-0.5	1.3	0.0	0.1	-0.2	-0.1	0.2	-0.0	-0.0	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	1.1	-0.0	1.1	-0.6	-0.5	-0.2	0.0	-0.4	0.1	0.1	0.1	-0.0	-0.0	-0.1	0.2	-0.2	-0.1	0.6
Age when periods started (menarche)	0.1	0.3	1.7	0.4	-1.3	-0.3	0.1	0.0	0.2	-1.3	-0.2	0.2	-0.3	0.4	-0.0	-0.0	0.4	0.1	-0.1	-0.5
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.7	-0.4	-0.5	-0.2	-0.6	0.3	0.1	0.0	0.0	-0.3	0.1	0.1	0.2	0.1	-0.8	0.1	0.3	0.5
Sitting height	0.1	0.4	2.2	0.5	-0.0	0.3	0.7	-0.5	-0.1	-0.3	-0.5	0.8	0.2	0.2	-0.1	0.3	1.5	0.5	0.2	1.2
High blood pressure (mother)	0.1	0.2	0.7	0.1	0.6	-0.4	-0.8	0.0	-0.4	0.3	-0.2	0.5	0.1	-0.4	-0.7	-0.4	0.5	-0.3	-0.3	0.4
Number of incorrect matches in round	0.1	0.2	0.6	0.4	0.1	0.5	0.8	0.1	0.4	-0.6	0.1	-0.1	0.1	0.3	0.5	0.4	0.5	0.4	0.3	0.1
Past tobacco smoking	0.1	0.1	0.7	0.1	-0.8	0.0	0.2	0.6	0.1	0.5	-0.2	0.2	0.1	0.1	0.1	0.1	-0.5	0.2	0.2	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	1.3	-0.1	0.6	-0.1	0.4	-0.8	-0.3	0.2	-0.2	-0.2	-0.5	-0.1	-0.3	-0.2	1.1	-0.2	-0.3	0.4
Heart attack	0.1	0.2	0.7	0.6	0.5	0.1	-0.2	0.2	0.6	-0.0	0.2	0.6	0.4	0.3	0.2	0.3	0.5	0.4	0.3	0.9
Prospective memory result	0.1	0.2	0.8	-0.6	0.9	0.3	0.7	-0.3	-0.5	-0.4	-0.5	-0.3	-0.3	-0.0	-0.2	-0.1	0.5	-0.2	-0.2	0.3
Standing height	0.1	1.0	7.9	0.7	1.2	0.2	0.9	-0.4	-0.1	-0.6	-0.7	0.9	0.2	0.1	-0.4	0.1	2.8	0.5	0.1	1.8
Hair/balding pattern: Pattern 4	0.1	0.3	1.0	-0.3	0.6	0.1	-0.5	-0.7	-0.6	-1.0	-0.7	-0.6	-0.6	-0.5	-0.3	-0.5	-0.0	-0.5	-0.5	-0.4
Birth weight	0.1	0.2	0.7	0.2	-0.4	-0.2	-0.4	0.7	0.2	0.5	0.3	0.9	0.7	-0.2	-0.3	-0.0	-0.2	0.1	0.2	0.6
Exposure to tobacco smoke outside home	0.1	0.1	0.7	0.4	0.5	-0.0	-0.1	-0.3	0.2	-0.8	-0.0	0.1	0.1	0.4	0.4	0.4	0.2	0.4	0.3	0.6
Number of children fathered	0.1	0.1	0.3	0.0	-0.5	-0.1	-0.0	0.2	0.5	-0.1	0.5	0.5	0.5	0.2	0.2	0.2	-0.3	0.3	0.3	0.3
Qualifications: College or University degree	0.1	0.4	1.0	-1.0	0.9	-0.2	0.6	-0.5	-0.9	-0.5	-0.8	-0.6	-0.3	-0.7	-0.4	-0.2	0.5	-0.2	-0.2	0.8
Medication: Seretide 50 evohaler	0.1	0.1	0.4	0.2	0.1	0.2	-0.1	0.1	-0.0	0.4	0.2	-0.0	0.1	-0.3	0.4	0.2	-0.6	-0.1	0.1	-0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.8	0.8	-0.9	0.2	-0.0	-0.2	0.3	-0.5	0.1	0.7	0.0	0.4	-0.2	-0.3	-0.2	-0.2	-0.2	-0.5
Back pain experienced in last month	0.1	0.2	0.5	0.2	-0.5	0.2	0.7	0.2	0.3	0.1	0.7	0.5	0.3	0.5	0.7	0.5	-0.1	0.5	0.4	-0.2
Breast cancer (self-reported)	0.1	0.1	0.5	0.0	0.7	-0.3	0.1	0.3	0.2	-0.5	0.4	0.0	0.4	0.1	0.3	0.4	0.7	0.3	0.3	0.3
Ever smoked	0.1	0.1	0.6	0.1	0.7	0.1	-0.1	-0.5	0.0	-0.4	0.4	0.3	-0.2	-0.0	-0.3	-0.3	0.2	-0.3	-0.3	0.4
Cholesterol lowering medication	0.1	0.2	1.1	0.8	1.1	0.2	0.4	0.1	0.1	0.2	-0.2	0.5	0.2	0.3	0.3	0.2	0.7	0.1	0.1	0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.6	0.4	0.4	-0.1	-0.4	0.2	0.5	-0.2	0.2	0.4	0.3	0.3	0.3	0.3	0.4	0.5	0.4	0.8
Blood Platelet Count	0.0	0.4	2.0	-0.5	-0.3	-0.5	-0.6	0.3	0.2	-0.1	0.8	-0.9	0.4	-0.3	1.0	0.7	-1.4	0.4	0.6	-0.3
Tanning	0.0	0.2	1.0	-0.1	1.0	-0.2	-0.6	-0.3	-0.5	0.1	-0.5	0.1	0.1	-0.1	-0.4	-0.3	0.3	-0.2	-0.2	0.6
Smoking status: Previous	0.0	0.0	0.1	-0.2	0.3	0.4	0.0	-0.1	-0.1	-0.1	0.2	-0.3	0.3	-0.1	0.1	-0.0	0.0	-0.1	-0.1	0.3
Loneliness, isolation	0.0	0.1	0.4	-0.2	0.2	0.0	0.1	0.2	0.0	-0.1	0.2	-0.1	0.2	-0.2	0.2	0.3	0.2	0.2	0.2	0.6

Hub : Genes

ADRA2B

Models

Trait associations