Best TWAS P=6.66e-08 · Best GWAS P=5.76e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Left Ventricle | ACVR2A | 0.07 | 0.08 | lasso | 1 | 0.07 | 9.3e-05 | 5.4 | 5.4 | 6.7e-08 | 1.00 | 0.02 | 0.97 | TRUE |
| 2 | GTEx | Testis | ORC4 | 0.24 | 0.24 | lasso | 16 | 0.24 | 8.9e-11 | 5.4 | 5.4 | 8.6e-08 | 0.99 | 0.02 | 0.98 | FALSE |
| 3 | YFS | Blood | ACVR2A | 0.08 | 0.09 | enet | 15 | 0.09 | 1.5e-27 | 5.0 | 5.2 | 2.1e-07 | 0.85 | 0.11 | 0.89 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ORC4L | 0.04 | 0.03 | enet | 7 | 0.03 | 5.4e-07 | 4.6 | 5.3 | 1.5e-07 | 0.80 | 0.03 | 0.96 | FALSE |