[Hub]/) : Traits : Diastolic blood pressure, automated reading :

chr12:122,625,212-124,715,313

Best TWAS P=1.81e-14 · Best GWAS P=5.93e-13 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex RILPL1 0.03 0.00 blup 379 0.02 1.5e-03 -7.0 -6.1 1.2e-09 0.74 0.06 0.77 FALSE
2 CommonMind Brain Pre-frontal Cortex SETD8 0.04 0.01 blup 352 0.02 2.8e-03 -4.5 5.5 3.4e-08 -0.80 0.12 0.86 TRUE
3 GTEx Adipose Subcutaneous CDK2AP1 0.20 0.18 lasso 11 0.19 1.0e-15 -6.8 6.8 1.2e-11 -0.92 0.14 0.86 FALSE
4 GTEx Adipose Subcutaneous RP11-282O18.3 0.15 0.14 lasso 7 0.15 2.0e-12 -6.9 7.0 2.2e-12 -0.93 0.13 0.87 FALSE
5 GTEx Adipose Visceral Omentum MPHOSPH9 0.07 0.02 lasso 4 0.00 3.5e-01 -6.7 -5.8 7.9e-09 0.90 0.05 0.65 FALSE
6 GTEx Adipose Visceral Omentum CDK2AP1 0.14 0.14 lasso 4 0.11 2.7e-06 -6.7 6.3 2.1e-10 -0.87 0.12 0.88 FALSE
7 GTEx Adipose Visceral Omentum ARL6IP4 0.08 0.02 lasso 5 0.06 3.7e-04 5.5 7.0 2.0e-12 -0.80 0.14 0.46 FALSE
8 GTEx Adipose Visceral Omentum RP11-282O18.3 0.14 0.11 enet 12 0.10 6.7e-06 -6.7 6.5 5.8e-11 -0.92 0.12 0.88 FALSE
9 GTEx Artery Aorta MPHOSPH9 0.08 0.01 lasso 4 0.04 4.6e-03 5.6 -7.5 9.0e-14 0.78 0.06 0.81 FALSE
10 GTEx Artery Aorta CDK2AP1 0.17 0.19 lasso 2 0.15 8.0e-09 -6.8 6.8 7.5e-12 -0.93 0.10 0.90 FALSE
11 GTEx Artery Aorta C12orf65 0.11 0.07 lasso 10 0.08 5.8e-05 -5.5 5.5 4.0e-08 -0.83 0.05 0.94 FALSE
12 GTEx Artery Aorta RP11-282O18.3 0.18 0.19 lasso 9 0.16 4.3e-09 -6.8 7.0 2.7e-12 -0.96 0.09 0.91 FALSE
13 GTEx Artery Tibial MPHOSPH9 0.05 0.03 lasso 3 0.03 2.2e-03 -5.5 -6.4 1.6e-10 0.93 0.08 0.87 FALSE
14 GTEx Artery Tibial PITPNM2 0.11 0.05 lasso 4 0.04 2.7e-04 -5.9 6.3 3.3e-10 -0.50 0.66 0.07 TRUE
15 GTEx Artery Tibial CDK2AP1 0.17 0.07 enet 36 0.09 1.1e-07 -5.5 5.3 9.4e-08 -0.68 0.14 0.86 FALSE
16 GTEx Artery Tibial ABCB9 0.04 0.02 lasso 2 0.01 3.0e-02 -4.8 -6.1 8.9e-10 0.92 0.09 0.84 FALSE
17 GTEx Artery Tibial SETD8 0.07 0.03 lasso 7 0.03 2.2e-03 -6.9 -6.4 1.3e-10 0.90 0.06 0.90 FALSE
18 GTEx Artery Tibial RP11-282O18.3 0.17 0.08 enet 26 0.10 2.4e-08 -5.5 5.3 1.2e-07 -0.66 0.13 0.87 FALSE
19 GTEx Brain Hypothalamus OGFOD2 0.24 0.14 lasso 4 0.14 4.0e-04 -7.0 -6.0 1.8e-09 0.86 0.12 0.75 FALSE
20 GTEx Breast Mammary Tissue CDK2AP1 0.08 0.06 lasso 3 0.07 1.2e-04 -6.9 7.0 1.9e-12 -0.95 0.05 0.93 FALSE
21 GTEx Breast Mammary Tissue RP11-282O18.3 0.10 0.06 lasso 6 0.08 5.4e-05 -6.9 7.3 3.7e-13 -0.96 0.04 0.95 FALSE
22 GTEx Breast Mammary Tissue (Female) CDK2AP1 0.08 0.03 lasso 3 0.02 6.4e-02 -7.0 7.3 2.3e-13 -0.96 0.04 0.74 FALSE
23 GTEx Breast Mammary Tissue (Female) RP11-282O18.3 0.09 0.07 enet 8 0.08 2.8e-03 -7.1 7.4 1.8e-13 -0.97 0.03 0.91 FALSE
24 GTEx Cells Transformed fibroblasts OGFOD2 0.10 0.07 lasso 7 0.07 3.1e-06 -5.4 -6.4 1.6e-10 0.92 0.22 0.78 FALSE
25 GTEx Cells Transformed fibroblasts CDK2AP1 0.31 0.32 lasso 8 0.35 8.5e-27 -6.8 6.7 1.6e-11 -0.93 0.17 0.83 FALSE
26 GTEx Cells Transformed fibroblasts C12orf65 0.07 0.05 lasso 4 0.04 5.8e-04 -5.6 6.9 5.8e-12 -0.92 0.11 0.82 FALSE
27 GTEx Cells Transformed fibroblasts ABCB9 0.08 0.12 enet 7 0.12 4.3e-09 -5.1 -5.7 1.3e-08 0.86 0.61 0.39 FALSE
28 GTEx Cells Transformed fibroblasts ARL6IP4 0.12 0.13 lasso 2 0.12 4.0e-09 -5.1 5.8 5.9e-09 -0.75 0.95 0.05 FALSE
29 GTEx Cells Transformed fibroblasts SETD8 0.10 0.12 enet 9 0.09 1.4e-07 -4.5 -6.4 1.5e-10 0.83 0.28 0.71 FALSE
30 GTEx Cells Transformed fibroblasts RP11-282O18.3 0.25 0.29 enet 16 0.28 2.2e-21 -6.8 6.8 1.2e-11 -0.94 0.16 0.84 FALSE
31 GTEx Colon Sigmoid CDK2AP1 0.12 0.02 enet 12 0.11 1.1e-04 -6.8 6.9 4.6e-12 -0.77 0.12 0.82 FALSE
32 GTEx Colon Sigmoid C12orf65 0.08 0.04 enet 12 0.06 3.0e-03 -4.7 5.5 3.4e-08 -0.76 0.09 0.77 FALSE
33 GTEx Colon Sigmoid ABCB9 0.18 0.16 lasso 6 0.15 4.8e-06 -6.5 -6.5 8.4e-11 0.92 0.11 0.87 FALSE
34 GTEx Colon Sigmoid RP11-282O18.3 0.16 0.03 enet 12 0.15 7.1e-06 -6.8 7.1 1.7e-12 -0.75 0.12 0.85 FALSE
35 GTEx Colon Transverse CDK2AP1 0.17 0.19 enet 7 0.22 1.4e-10 -7.0 7.1 1.5e-12 -0.95 0.10 0.90 FALSE
36 GTEx Colon Transverse ABCB9 0.08 0.07 enet 5 0.09 5.3e-05 -6.8 -6.4 1.5e-10 0.88 0.16 0.78 FALSE
37 GTEx Colon Transverse RP11-282O18.3 0.18 0.19 enet 8 0.19 1.8e-09 -7.0 7.1 1.4e-12 -0.96 0.09 0.91 FALSE
38 GTEx Esophagus Gastroesophageal Junction CDK2AP1 0.14 0.06 lasso 8 0.06 4.7e-03 -6.8 6.1 1.3e-09 -0.78 0.07 0.40 FALSE
39 GTEx Esophagus Gastroesophageal Junction RP11-282O18.3 0.16 0.06 lasso 9 0.07 2.3e-03 -6.8 5.9 2.9e-09 -0.85 0.08 0.54 FALSE
40 GTEx Esophagus Mucosa CDK2AP1 0.30 0.36 lasso 5 0.38 1.9e-26 -7.0 6.8 1.0e-11 -0.96 0.07 0.93 FALSE
41 GTEx Esophagus Mucosa HIP1R 0.21 0.05 lasso 5 0.07 1.5e-05 3.7 5.4 6.7e-08 -0.20 0.62 0.02 FALSE
42 GTEx Esophagus Mucosa ABCB9 0.10 0.03 lasso 5 0.05 5.4e-04 -6.7 -7.2 6.6e-13 0.88 0.10 0.88 FALSE
43 GTEx Esophagus Mucosa RP11-282O18.3 0.29 0.34 lasso 4 0.34 1.9e-23 -6.8 6.6 3.7e-11 -0.94 0.11 0.89 FALSE
44 GTEx Esophagus Muscularis MPHOSPH9 0.18 0.18 enet 17 0.18 4.8e-11 -6.4 -7.1 1.3e-12 0.89 0.20 0.80 FALSE
45 GTEx Esophagus Muscularis CDK2AP1 0.17 0.10 enet 18 0.11 4.6e-07 -7.0 6.6 3.4e-11 -0.80 0.08 0.92 FALSE
46 GTEx Esophagus Muscularis C12orf65 0.06 0.04 lasso 4 0.04 2.0e-03 -6.7 6.2 6.1e-10 -0.91 0.15 0.78 FALSE
47 GTEx Esophagus Muscularis ABCB9 0.10 0.08 lasso 6 0.05 3.8e-04 -6.8 -7.4 1.1e-13 0.93 0.09 0.89 FALSE
48 GTEx Esophagus Muscularis RP11-282O18.3 0.19 0.11 lasso 6 0.10 2.1e-06 -7.0 6.9 5.1e-12 -0.93 0.09 0.91 FALSE
49 GTEx Heart Left Ventricle MPHOSPH9 0.06 0.04 lasso 5 0.04 4.2e-03 -6.7 -7.1 1.3e-12 0.86 0.06 0.84 FALSE
50 GTEx Heart Left Ventricle ABCB9 0.10 0.14 lasso 5 0.10 4.2e-06 -6.5 -6.3 3.1e-10 0.82 0.14 0.85 FALSE
51 GTEx Liver ABCB9 0.32 0.32 lasso 3 0.28 1.9e-08 -5.1 -5.2 2.3e-07 0.76 0.27 0.67 FALSE
52 GTEx Lung CDK2AP1 0.08 0.03 lasso 4 0.00 2.0e-01 -6.8 6.1 9.9e-10 -0.91 0.10 0.84 FALSE
53 GTEx Lung ABCB9 0.04 0.02 lasso 3 0.02 8.0e-03 -6.7 -6.6 3.8e-11 0.94 0.13 0.67 FALSE
54 GTEx Lung RP11-282O18.3 0.06 0.02 lasso 7 0.00 6.1e-01 -6.8 6.7 2.9e-11 -0.93 0.09 0.79 FALSE
55 GTEx Muscle Skeletal SETD8 0.16 0.02 lasso 4 0.03 3.8e-04 -6.7 -6.3 2.4e-10 0.86 0.15 0.82 FALSE
56 GTEx Nerve Tibial MPHOSPH9 0.07 0.04 lasso 4 0.01 7.0e-02 -6.5 -7.0 2.1e-12 0.93 0.09 0.78 FALSE
57 GTEx Nerve Tibial CDK2AP1 0.11 0.11 enet 25 0.09 4.4e-07 -6.9 7.3 3.2e-13 -0.92 0.12 0.88 FALSE
58 GTEx Nerve Tibial C12orf65 0.05 0.07 lasso 3 0.06 3.0e-05 -5.5 6.1 8.7e-10 -0.90 0.08 0.87 FALSE
59 GTEx Nerve Tibial ABCB9 0.06 0.04 lasso 3 0.05 3.5e-04 -6.8 -7.0 2.3e-12 0.94 0.10 0.87 FALSE
60 GTEx Nerve Tibial RP11-282O18.3 0.10 0.10 enet 28 0.08 1.9e-06 -6.9 7.0 2.0e-12 -0.85 0.12 0.88 FALSE
61 GTEx Pancreas MPHOSPH9 0.14 0.01 enet 31 0.07 9.3e-04 -6.7 7.0 2.8e-12 -0.50 0.07 0.65 TRUE
62 GTEx Pancreas CDK2AP1 0.24 0.27 lasso 3 0.26 3.1e-11 -7.0 7.0 2.5e-12 -0.96 0.08 0.92 FALSE
63 GTEx Pancreas ABCB9 0.12 0.00 lasso 12 -0.01 6.3e-01 5.5 -6.2 7.9e-10 0.51 0.07 0.12 TRUE
64 GTEx Pancreas ARL6IP4 0.07 0.07 lasso 2 0.07 9.6e-04 -6.5 6.9 7.1e-12 -0.89 0.06 0.78 FALSE
65 GTEx Pancreas SETD8 0.20 0.12 lasso 5 0.13 3.4e-06 -6.8 6.6 4.5e-11 -0.91 0.16 0.83 FALSE
66 GTEx Pancreas RP11-282O18.3 0.22 0.24 lasso 5 0.24 2.3e-10 -6.8 7.0 3.7e-12 -0.95 0.10 0.90 TRUE
67 GTEx Skin Not Sun Exposed Suprapubic CDK2AP1 0.17 0.12 lasso 10 0.12 3.4e-07 -6.5 7.1 1.1e-12 -0.95 0.09 0.91 FALSE
68 GTEx Skin Not Sun Exposed Suprapubic ABCB9 0.13 0.15 lasso 11 0.11 2.1e-06 -5.1 -6.5 1.1e-10 0.83 0.21 0.79 FALSE
69 GTEx Skin Not Sun Exposed Suprapubic RP11-282O18.3 0.13 0.10 lasso 6 0.09 1.9e-05 -6.7 7.0 1.8e-12 -0.95 0.10 0.90 FALSE
70 GTEx Skin Sun Exposed Lower leg MPHOSPH9 0.06 0.05 enet 9 0.06 2.1e-05 -7.0 -7.7 1.8e-14 0.89 0.07 0.90 TRUE
71 GTEx Skin Sun Exposed Lower leg CDK2AP1 0.21 0.22 lasso 5 0.22 3.4e-18 -6.8 7.0 2.9e-12 -0.93 0.17 0.83 FALSE
72 GTEx Skin Sun Exposed Lower leg ABCB9 0.09 0.08 lasso 5 0.08 4.3e-07 -5.1 -6.3 3.3e-10 0.81 0.16 0.84 FALSE
73 GTEx Skin Sun Exposed Lower leg RP11-282O18.3 0.17 0.20 lasso 6 0.20 2.2e-16 -6.8 6.7 1.7e-11 -0.92 0.16 0.84 FALSE
74 GTEx Small Intestine Terminal Ileum ABCB9 0.23 0.21 enet 12 0.22 1.0e-05 -6.7 -7.0 2.1e-12 0.88 0.13 0.58 FALSE
75 GTEx Stomach MPHOSPH9 0.17 0.08 lasso 5 0.10 1.2e-05 -6.8 -6.9 4.6e-12 0.94 0.07 0.92 FALSE
76 GTEx Testis MPHOSPH9 0.28 0.27 enet 23 0.32 1.3e-14 -6.7 -6.9 4.0e-12 0.96 0.04 0.96 FALSE
77 GTEx Testis CDK2AP1 0.20 0.14 lasso 5 0.13 2.0e-06 -6.7 6.4 1.9e-10 -0.82 0.07 0.93 FALSE
78 GTEx Thyroid MPHOSPH9 0.10 0.08 enet 20 0.09 2.0e-07 -6.9 -6.6 3.3e-11 0.93 0.05 0.95 FALSE
79 GTEx Thyroid PITPNM2 0.04 0.07 lasso 2 0.06 1.6e-05 -7.0 -7.0 2.0e-12 0.95 0.06 0.92 FALSE
80 GTEx Thyroid CDK2AP1 0.08 0.09 enet 7 0.10 8.2e-08 -6.8 7.1 1.4e-12 -0.95 0.11 0.89 FALSE
81 GTEx Thyroid RP11-282O18.3 0.06 0.06 enet 6 0.06 3.6e-05 -6.8 7.0 2.6e-12 -0.94 0.10 0.90 FALSE
82 METSIM Adipose CDK2AP1 0.11 0.14 enet 23 0.14 1.7e-20 -6.8 7.2 7.3e-13 -0.92 0.12 0.88 FALSE
83 METSIM Adipose MPHOSPH9 0.03 0.01 bslmm 348 0.01 1.2e-02 -7.2 -6.6 4.1e-11 0.77 0.04 0.88 FALSE
84 NTR Blood ARL6IP4 0.01 0.02 enet 9 0.01 9.8e-06 5.5 5.1 3.1e-07 -0.57 0.47 0.27 FALSE
85 YFS Blood MPHOSPH9 0.05 0.07 enet 31 0.07 3.7e-23 -6.7 -6.4 1.3e-10 0.96 0.03 0.97 FALSE
86 YFS Blood SBNO1 0.03 0.03 lasso 6 0.03 1.2e-09 -6.8 6.1 9.2e-10 -0.93 0.06 0.94 FALSE
87 The Cancer Genome Atlas Bladder Urothelial Carcinoma ABCB9 0.05 0.04 enet 5 0.04 2.4e-04 -6.7 -5.7 1.6e-08 0.90 0.00 0.98 FALSE
88 The Cancer Genome Atlas Bladder Urothelial Carcinoma CDK2AP1 0.09 0.08 lasso 2 0.06 5.9e-06 -6.8 6.8 1.4e-11 -0.92 0.02 0.98 FALSE
89 The Cancer Genome Atlas Breast Invasive Carcinoma CDK2AP1 0.07 0.08 lasso 7 0.08 5.0e-16 -6.8 7.1 1.4e-12 -0.97 0.01 0.99 FALSE
90 The Cancer Genome Atlas Breast Invasive Carcinoma RILPL2 0.02 0.01 enet 8 0.01 2.6e-02 -6.8 -6.6 4.9e-11 0.85 0.01 0.98 FALSE
91 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CDK2AP1 0.07 0.07 blup 34 0.05 1.1e-03 -6.8 7.2 6.1e-13 -0.96 0.01 0.89 FALSE
92 The Cancer Genome Atlas Colon Adenocarcinoma CDK2AP1 0.12 0.17 lasso 4 0.17 6.3e-10 -6.8 6.8 9.7e-12 -0.93 0.01 0.99 FALSE
93 The Cancer Genome Atlas Colon Adenocarcinoma RILPL2 0.09 0.09 blup 43 0.08 3.1e-05 -6.9 -6.4 1.9e-10 0.83 0.01 0.99 FALSE
94 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ABCB9 0.03 0.02 enet 9 0.03 3.4e-04 -6.7 -5.8 4.9e-09 0.77 0.00 0.93 TRUE
95 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CDK2AP1 0.14 0.15 lasso 2 0.14 7.8e-16 -6.8 6.7 2.0e-11 -0.92 0.06 0.94 FALSE
96 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CDK2AP1 0.11 0.13 lasso 5 0.14 5.9e-16 -6.8 7.0 2.8e-12 -0.97 0.01 0.99 FALSE
97 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma C12orf65 0.05 0.04 blup 34 0.05 1.0e-03 -4.5 5.8 5.7e-09 -0.81 0.04 0.68 FALSE
98 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CDK2AP1 0.12 0.10 lasso 2 0.11 6.3e-07 -6.8 6.7 2.6e-11 -0.91 0.04 0.96 FALSE
99 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PITPNM2 0.06 0.07 lasso 5 0.09 1.2e-05 -7.2 6.7 1.9e-11 -0.96 0.02 0.97 FALSE
100 The Cancer Genome Atlas Liver Hepatocellular Carcinoma ABCB9 0.19 0.22 enet 9 0.22 7.7e-11 -4.8 -5.7 1.0e-08 0.79 0.57 0.43 FALSE
101 The Cancer Genome Atlas Liver Hepatocellular Carcinoma CDK2AP1 0.11 0.11 enet 5 0.11 1.2e-05 -6.8 6.9 5.5e-12 -0.94 0.01 0.98 FALSE
102 The Cancer Genome Atlas Lung Adenocarcinoma CDK2AP1 0.03 0.04 lasso 1 0.04 1.2e-05 -6.8 6.8 1.4e-11 -0.92 0.02 0.98 FALSE
103 The Cancer Genome Atlas Lung Adenocarcinoma RILPL2 0.04 0.02 blup 43 0.02 6.1e-04 -5.8 -5.8 5.7e-09 0.69 0.01 0.94 FALSE
104 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ABCB9 0.06 0.06 enet 7 0.07 5.2e-08 -5.3 -5.8 8.0e-09 0.85 0.05 0.95 FALSE
105 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CDK2AP1 0.04 0.04 lasso 3 0.03 3.8e-04 -6.8 6.7 2.0e-11 -0.93 0.02 0.95 FALSE
106 The Cancer Genome Atlas Lung Squamous Cell Carcinoma OGFOD2 0.02 0.04 lasso 3 0.03 1.3e-04 -5.0 -5.2 2.7e-07 0.77 0.01 0.94 FALSE
107 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma CDK2AP1 0.07 0.06 enet 7 0.06 7.0e-05 -6.8 7.0 2.0e-12 -0.88 0.01 0.93 FALSE
108 The Cancer Genome Atlas Pancreatic Adenocarcinoma CDK2AP1 0.12 0.14 blup 34 0.15 7.2e-07 -6.5 7.5 5.1e-14 -0.93 0.02 0.98 FALSE
109 The Cancer Genome Atlas Prostate Adenocarcinoma ARL6IP4 0.03 0.04 blup 17 0.04 1.6e-05 -5.4 6.5 6.4e-11 -0.83 0.04 0.94 FALSE
110 The Cancer Genome Atlas Prostate Adenocarcinoma CDK2AP1 0.06 0.07 lasso 2 0.06 1.7e-06 -6.8 6.7 1.5e-11 -0.92 0.02 0.98 FALSE
111 The Cancer Genome Atlas Stomach Adenocarcinoma CDK2AP1 0.09 0.10 lasso 2 0.10 1.8e-07 -6.8 7.0 2.7e-12 -0.93 0.01 0.99 FALSE
112 The Cancer Genome Atlas Testicular Germ Cell Tumors CDK2AP1 0.13 0.10 blup 34 0.11 8.2e-05 -6.7 6.8 8.6e-12 -0.92 0.01 0.97 FALSE
113 The Cancer Genome Atlas Thyroid Carcinoma CDK2AP1 0.08 0.10 lasso 2 0.10 1.3e-09 -6.8 6.8 9.0e-12 -0.93 0.04 0.96 FALSE
114 The Cancer Genome Atlas Thyroid Carcinoma MPHOSPH9 0.27 0.09 lasso 4 0.09 9.8e-09 -5.6 -6.2 4.5e-10 0.82 0.08 0.92 FALSE
115 The Cancer Genome Atlas Thyroid Carcinoma OGFOD2 0.02 0.00 enet 4 0.02 2.7e-03 -5.3 -5.3 1.1e-07 0.71 0.01 0.40 FALSE
116 The Cancer Genome Atlas Thyroid Carcinoma PITPNM2 0.04 0.03 enet 5 0.05 8.1e-06 -4.5 -7.2 4.2e-13 0.75 0.03 0.96 FALSE
117 The Cancer Genome Atlas Thyroid Carcinoma SBNO1 0.03 0.01 blup 59 0.02 9.4e-03 -6.8 6.4 1.2e-10 -0.72 0.01 0.64 FALSE