TWAS hub - HIP1R

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.058	0.031	3.6e-03	0.021	0.013	0.037	0.019	0.038	1.1e-03	0.0081	2.4e-05	0.0019	1.9e-05
2	GTEx	Esophagus Mucosa	0.214	0.072	5.7e-06	0.049	NA	0.055	NA	0.072	3.1e-04	NA	1.5e-04	NA	1.5e-05
3	GTEx	Skin Sun Exposed Lower leg	0.092	0.031	6.5e-05	0.115	NA	0.093	NA	0.110	8.8e-10	NA	4.2e-08	NA	2.1e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Leg fat mass (right)	9.7	37.7	61.7	-6.1	7.9	3.8
Leg fat mass (left)	9.5	37.3	60.8	-6.1	7.8	3.7
Body mass index (BMI)	9.2	39.0	59.1	-6.4	7.7	4.1
Leg fat percentage (right)	9.1	33.1	49.8	-6.0	7.1	3.6
Hip circumference	9.0	38.8	61.0	-5.9	7.8	4.5
Whole body fat mass	9.0	37.7	63.7	-5.8	8.0	4.1
Arm fat percentage (left)	8.9	35.4	56.7	-5.8	7.5	3.9
Body fat percentage	8.7	34.5	56.4	-5.6	7.5	4.0
Leg fat percentage (left)	8.7	31.6	47.5	-5.9	6.9	3.5
Diabetes diagnosed by doctor	8.5	14.0	16.1	-3.7	4.0	3.5
Trunk fat mass	8.4	35.9	61.8	-5.4	7.9	4.0
Arm fat mass (right)	8.4	34.7	58.6	-5.7	7.7	3.6
Arm fat mass (left)	8.4	34.6	57.0	-5.8	7.5	3.7
Arm fat percentage (right)	8.1	32.0	52.9	-5.5	7.3	3.6
Trunk fat percentage	8.0	32.0	53.0	-5.2	7.3	4.0
Diastolic blood pressure, automated reading	7.1	21.9	29.2	-4.8	5.4	3.6
BMI	7.0	40.8	70.2	-6.2	8.4	3.8
Medication: Metformin	7.0	9.9	11.6	-3.4	3.1	2.9
Diabetes (self-reported)	6.8	10.5	12.3	-2.7	3.4	3.5
Weight	6.6	32.5	57.0	-5.2	7.5	3.6
Alzheimer’s Disease (in mother)	6.5	7.6	11.6	2.2	-3.4	-2.5
Type 2 Diabetes (T2D) (2018)	6.3	11.8	13.7	-3.0	3.7	3.5
Mouth/teeth dental problems	5.6	8.6	13.0	-3.4	3.6	1.2
Medication for hormone replacement therapy	5.5	6.2	8.2	-1.5	2.8	2.9
Pulse rate, automated reading	5.5	17.7	26.2	-4.8	5.1	2.0
Taking other prescription medications	5.0	7.8	8.8	-2.8	3.0	2.6
Waist Hip Ratio (WHR)	4.9	22.1	35.9	6.0	-5.0	-2.3
Father’s age at death	4.5	6.0	9.2	2.3	-3.0	-1.9
Pulse rate	4.3	7.3	11.8	-3.4	3.1	0.5
Medication for cholesterol	4.3	6.5	7.5	2.7	-2.5	-2.3
Waist circumference	4.2	15.3	26.4	-3.2	5.1	3.1
Long-standing illness, disability or infirmity	4.2	6.4	8.6	-2.5	2.9	2.0
Alzheimer’s Disease (including proxy)	4.0	5.8	8.8	1.8	-2.3	-3.0
Commuting to job workplace: Walk	3.9	4.3	6.7	-1.7	1.8	2.6
Medication: Cholesterol lowering	3.8	6.0	8.3	-1.6	2.7	2.9
HDL Cholesterol	3.7	6.2	9.8	-3.1	2.3	1.8
High cholesterol (Self-reported)	3.6	6.3	12.2	-1.5	2.1	3.5
Leg fat-free mass (left)	3.5	18.4	36.3	-3.5	6.0	2.6
Leg predicted mass (left)	3.4	18.2	35.9	-3.4	6.0	2.7
Commuting to job workplace: Cycle	3.4	4.1	7.1	2.0	-2.7	-1.1
Mouth/teeth dental problems: Loose teeth	3.3	4.0	6.8	2.1	-2.6	-0.9
Fractured/broken bones in last 5 years	3.3	4.3	5.7	2.2	-2.4	-1.5
Medication: Co-codamol	3.2	3.7	6.9	-1.7	2.6	1.1
HbA1C	3.1	3.4	5.6	-2.4	2.0	0.9
Number of treatments/medications taken	3.1	5.6	6.1	-2.1	2.5	2.5
Frequency of tiredness / lethargy in last 2 weeks	3.1	5.0	6.1	-2.5	2.3	1.9
Mouth/teeth dental problems: Bleeding gums	3.1	4.0	5.2	1.9	-2.3	-1.8
Number of self-reported non-cancer illnesses	3.1	5.4	6.3	-2.0	2.5	2.5
Hearing aid user	3.1	3.5	5.0	0.7	-2.2	-2.2
Cardiovascular Disease	3.0	10.0	11.7	-2.7	3.3	3.4
Leg fat-free mass (right)	3.0	16.0	31.7	-3.2	5.6	2.5
Leg predicted mass (right)	3.0	15.8	31.2	-3.2	5.6	2.5
Basal metabolic rate	3.0	16.7	32.8	-3.4	5.7	2.4
Serious illness, injury or assault of a close relative in last 2 years	2.9	3.3	4.8	-1.6	1.7	2.2
Medication: Amlodipine	2.9	4.0	4.5	-1.8	2.0	2.1
Medication: Gliclazide	2.9	3.3	4.2	-1.3	2.0	2.0
Pain type(s) experienced in last month: Hip pain	2.9	3.7	5.0	-1.1	2.2	2.2
Heart disease (mother)	2.8	3.4	5.6	-0.6	2.0	2.4
Pulse wave reflection index	2.7	3.4	3.8	1.9	-1.9	-1.7
Illnesses of father: None of the above (group 1)	2.7	3.3	4.5	2.1	-2.1	-1.1
Arm fat-free mass (left)	2.7	13.5	25.2	-3.2	5.0	2.2
Financial difficulties in last 2 years	2.6	3.5	5.4	-1.2	2.3	2.0
Age started oral contraceptive pill	2.6	3.2	5.8	0.9	-2.4	-1.7
Arm predicted mass (left)	2.6	13.3	24.7	-3.3	5.0	2.1
Ever had hysterectomy (womb removed)	2.5	2.8	4.8	-2.2	1.6	1.1
Headache pain in last month	2.5	4.3	7.4	1.1	-2.7	-2.1
Arm predicted mass (right)	2.5	12.5	22.5	-3.3	4.7	2.0
Illness, injury, bereavement, stress in last 2 years	2.5	3.0	3.9	1.2	-2.0	-1.9
Fed-up feelings	2.4	4.4	5.5	-2.1	2.4	1.8
Noisy workplace	2.4	3.0	6.7	0.3	1.5	2.6
Mouth/teeth dental problems: Mouth ulcers	2.4	3.9	7.3	1.9	-2.7	-0.9
Risk taking	2.4	3.5	4.4	-2.1	2.0	1.3
Verbal and Numeric Reasoning (VNR)	2.3	5.5	10.1	2.3	-3.2	-1.1
Lupus	2.3	3.4	4.9	-2.2	1.3	1.9
Hayfever/allergic rhinitis (self-reported)	2.3	3.1	5.3	-2.3	1.7	0.9
Arm fat-free mass (right)	2.3	11.8	21.6	-3.1	4.7	2.0
Financial situation satisfaction	2.3	2.9	4.2	-1.5	1.5	2.0
Alzheimer’s Disease (in father)	2.2	2.3	5.3	0.5	-1.2	-2.3
High blood pressure	2.2	6.3	6.5	-2.5	2.5	2.5
Breastfed as a baby	2.2	2.7	3.8	2.0	-1.8	-1.0
Had major operations	2.2	2.6	4.2	-2.0	1.4	1.3
Hypertension (Self-reported)	2.2	6.1	6.4	-2.4	2.5	2.5
Health satisfaction	2.1	2.8	3.7	-1.9	1.6	1.4
Shortness of breath walking on level ground	2.1	2.5	3.2	-1.6	1.8	1.3
Overall health rating	2.1	4.4	7.7	-1.1	2.1	2.8
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	3.6	-1.9	1.5	1.0
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.6	6.7	-2.6	1.9	1.9
Medication: Ramipril	2.0	2.6	4.6	-0.7	1.7	2.2
Whole body fat-free mass	2.0	11.5	23.5	-2.7	4.8	1.9
Back pain experienced in last month	2.0	3.0	4.9	-2.2	2.0	0.2
Whole body water mass	2.0	11.3	23.3	-2.7	4.8	1.9
Miserableness	2.0	3.4	5.1	-1.6	1.6	2.3
Depression (self-reported)	1.9	2.3	3.5	-1.9	1.6	1.0
Intelligence (Savage-Jansen 2018)	1.8	5.4	8.7	2.5	-3.0	-1.1
Rheumatoid Arthritis	1.8	2.4	3.4	-1.0	1.7	1.8
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	3.6	0.3	1.8	1.9
Stomach or abdominal pain in last month	1.8	2.3	2.7	-1.6	1.6	1.3
Smoking status: Previous	1.8	2.7	3.5	1.9	-1.7	-1.3
Heel T-Score	1.7	13.1	18.5	-4.3	3.3	3.1
Hearing difficulty/problems: Yes	1.7	2.6	4.0	2.0	-1.7	-0.9
Chronic bronchitis/emphysema (father)	1.7	2.0	3.7	-1.0	1.2	1.9
Medication: Simvastatin	1.7	2.5	4.5	-0.7	1.6	2.1
Medication for cholesterol, blood pressure or diabetes	1.7	2.9	4.3	0.9	-1.9	-2.1
Smoking status: Current	1.7	2.7	5.0	-1.2	1.4	2.2
Vascular/heart problems diagnosed by doctor	1.7	4.5	6.9	1.5	-2.1	-2.6
Depressed Affect (Nagel 2018)	1.6	3.3	4.1	-1.6	1.8	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	2.8	-1.3	1.7	1.3
Illnesses of siblings	1.6	2.2	2.6	1.3	-1.6	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	3.3	-1.8	1.6	0.7
Number of children fathered	1.6	1.8	2.6	1.6	-1.3	-1.0
Knee pain experienced in last month	1.6	2.4	4.1	-1.3	2.0	1.2
Breast cancer (self-reported)	1.6	1.9	3.1	0.1	-1.6	-1.7
Osteoarthritis (self-reported)	1.6	2.1	3.2	-1.8	1.6	0.7
Supplements: Calcium	1.6	1.8	3.8	1.9	-1.2	0.2
Reaction Time	1.5	2.9	4.0	-1.0	2.0	1.9
Crohns Disease (2012)	1.5	2.4	5.1	2.3	-1.4	-0.6
Diabetes (mother)	1.5	2.0	4.3	-0.6	-1.1	-2.1
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.5	4.3	-2.1	1.9	1.6
Commuting to job workplace: Public transport	1.5	1.8	3.6	1.9	-1.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	5.0	-2.2	0.7	-0.3
Current tobacco smoking	1.4	2.3	4.7	-0.9	1.2	2.2
Medication: Levothyroxine sodium	1.4	2.4	3.0	-1.7	1.2	1.7
High blood pressure (siblings)	1.4	2.0	3.2	-0.9	1.4	1.8
Illnesses of father: Heart disease	1.4	1.9	3.4	-1.8	1.4	0.6
Heart disease (siblings)	1.4	1.7	2.4	-0.7	1.5	1.5
Blood Eosinophil Count	1.3	10.3	13.2	-3.1	3.6	2.9
Pack years adult smoking proportion	1.3	2.0	3.7	0.5	1.5	1.9
Time employed in main current job	1.3	1.4	2.8	-0.3	1.7	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.0	7.6	-2.0	2.8	0.7
Guilty feelings	1.3	2.0	2.8	-1.5	1.0	1.7
Ever smoked	1.3	2.4	4.4	1.2	-2.1	-1.1
Ovarian Cancer	1.2	1.6	2.6	-0.8	1.2	1.6
Mean Putamen Volume	1.2	1.3	1.5	-1.2	1.1	1.2
Average weekly spirits intake	1.2	1.4	2.6	-1.1	1.6	0.7
Nervous feelings	1.2	2.2	4.0	1.0	-2.0	-1.3
Loneliness, isolation	1.2	1.6	3.2	-0.3	1.2	1.8
Relative age of first facial hair	1.1	2.2	3.1	1.5	-1.2	-1.8
Relative age voice broke	1.1	1.7	4.5	2.1	-0.5	-0.4
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.3	-1.5	0.7	0.9
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	6.4	-2.1	2.5	0.0
Mouth/teeth dental problems: Dentures	1.1	1.8	2.8	1.7	-1.6	-0.2
Trunk predicted mass	1.1	6.3	13.8	-1.9	3.7	1.2
Ever highly irritable/argumentative for 2 days	1.1	1.4	3.3	-1.8	0.9	0.1
Medication: Omeprazole	1.1	1.3	2.4	-1.5	1.2	0.5
Medication: Blood pressure	1.1	2.2	5.5	-2.3	0.9	0.5
Pack years of smoking	1.1	1.6	2.8	0.6	1.2	1.7
Schizophrenia vs Biploar Disorder	1.0	1.3	1.9	1.4	-1.2	-0.8
Vitamin and mineral supplements	1.0	1.4	2.4	-0.4	-1.2	-1.6
Hayfever, allergic rhinitis or eczema	1.0	2.1	4.2	-1.5	2.1	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.9	-1.0	1.0	1.7
Hearing difficulty/problems with background noise	1.0	1.6	3.1	1.2	-1.8	-0.6
Fluid intelligence score	1.0	2.1	3.5	1.4	-1.9	-0.9
Trunk fat-free mass	1.0	6.0	13.3	-1.8	3.6	1.1
Glaucoma (self-reported)	1.0	1.2	3.2	1.8	-0.5	0.4
Chronic bronchitis/emphysema (mother)	1.0	1.1	1.6	-1.3	1.1	0.8
Forced vital capacity (FVC), Best measure	1.0	3.7	8.3	-1.5	2.9	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.6	-1.6	-0.2	-0.9
Supplements: Fish oil (including cod liver oil)	1.0	1.4	1.7	1.3	-1.0	-1.2
Medication: Paracetamol	1.0	1.6	3.1	-0.3	-1.3	-1.7
Alcohol drinker status: Never	1.0	1.2	1.6	-0.9	1.3	1.1
Sensitivity / hurt feelings	0.9	1.5	3.3	-0.3	1.0	1.8
Frequency of depressed mood in last 2 weeks	0.9	1.3	1.4	-1.2	1.0	1.2
Impedance of leg (right)	0.9	4.5	7.7	2.1	-2.8	-1.1
Supplements: Glucosamine	0.9	1.2	2.5	-1.0	1.6	0.4
Impedance of leg (left)	0.9	4.2	7.7	1.9	-2.8	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.1	-0.6	1.4	1.0
Medication: Blood pressure	0.9	1.6	3.1	0.4	1.3	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	1.8	0.7	-1.0	-1.3
Average weekly red wine intake	0.9	1.3	2.6	-1.6	-0.7	-0.9
Friendships satisfaction	0.9	1.2	1.8	-1.4	0.5	1.2
Cholesterol lowering medication	0.9	1.3	2.6	-1.6	0.5	1.1
LDL Cholesterol	0.8	1.3	3.3	-1.8	0.7	0.3
Type 2 Diabetes (T2D) (2012)	0.8	1.0	1.4	-1.0	1.2	0.7
Number of incorrect matches in round	0.8	1.2	1.5	-1.2	0.9	1.2
Past tobacco smoking	0.8	1.5	2.6	-1.0	1.6	1.0
Pain all over the body in last month	0.8	0.8	2.3	1.5	0.3	0.3
Neuroticism score	0.8	1.7	2.2	-1.5	1.1	1.3
Happiness	0.8	1.0	2.1	-1.5	0.4	0.8
Illnesses of mother	0.8	0.9	2.0	-0.0	0.9	1.4
Chest pain or discomfort	0.8	1.2	2.3	1.5	-1.0	0.3
Qualifications: nursing, teaching	0.8	1.3	2.8	1.7	-0.1	1.1
Medication: Aspirin	0.8	1.0	2.4	1.6	-0.8	0.1
Average weekly beer plus cider intake	0.8	1.2	1.4	-0.9	1.2	1.1
Body Mass Index (BMI) (2010)	0.7	1.0	1.9	-0.9	1.4	0.5
Allergy or Eczema	0.7	1.9	2.9	-1.7	1.7	-0.2
Hypothyroidism (self reported)	0.7	1.5	1.7	-1.2	1.3	1.1
Neuroticism	0.7	1.7	2.8	-1.7	1.0	1.1
Multivitamins +/- minerals	0.7	0.9	1.5	0.2	1.1	1.2
Forced vital capacity (FVC)	0.7	2.6	6.3	-1.3	2.5	-0.2
Number of live births	0.7	0.9	1.3	-0.6	-1.1	-1.1
Qualifications: A levels/AS levels or equivalent	0.7	1.4	1.8	1.2	-1.3	-1.1
Number of full brothers	0.7	0.9	1.6	1.0	-1.3	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	1.3	-0.2	1.1	1.1
Age at first live birth	0.7	1.2	2.6	0.6	-0.8	-1.6
Supplements: Vitamin C	0.7	0.9	1.3	-0.3	1.1	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	1.4	0.4	1.0	1.2
Osteoporosis (self-reported)	0.7	0.9	1.7	-1.3	0.5	0.8
Eye problems/disorders: Glaucoma	0.7	0.9	2.0	1.4	-0.3	0.7
Impedance of whole body	0.7	3.7	5.9	2.1	-2.4	-0.9
Worry (Nagel 2018)	0.6	1.2	1.7	0.9	-1.3	-1.1
Hair/balding pattern: Pattern 2	0.6	0.7	1.6	1.3	-0.7	0.0
Had other major operations	0.6	0.8	1.3	1.2	-0.8	-0.5
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.3	-1.1	-0.7	-0.8
Impedance of arm (right)	0.6	2.6	5.7	2.4	-1.4	-0.4
Hair/balding pattern: Pattern 3	0.6	0.9	1.2	-1.1	1.1	0.6
Impedance of arm (left)	0.6	2.7	5.1	2.2	-1.7	-0.5
Medication: Paracetamol	0.6	1.1	2.1	-0.7	-0.8	-1.4
Medication: Allopurinol	0.6	0.7	1.3	0.9	-1.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.9	1.7	-0.5	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.2	-0.7	-0.5	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	2.1	-1.4	1.4	-0.2
Average weekly champagne plus white wine intake	0.6	0.8	2.1	-0.1	-0.5	-1.4
Bipolar Disorder or Schizophrenia	0.5	1.2	2.4	-0.8	1.5	0.7
Systolic blood pressure, automated reading	0.5	1.4	2.0	-1.2	1.4	0.9
Supplements: Zinc	0.5	0.5	1.2	0.4	0.5	1.1
Townsend deprivation index at recruitment	0.5	0.7	1.7	0.3	-0.4	1.3
Alcohol usually taken with meals	0.5	0.8	1.2	-0.5	-1.0	-1.1
Medication: Lansoprazole	0.5	0.6	0.9	-0.9	0.9	-0.4
Tense / ‘highly strung’	0.5	0.8	1.0	-1.0	0.9	0.7
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	1.3	-1.1	0.8	1.1
Exposure to tobacco smoke outside home	0.5	0.7	1.9	1.4	-0.2	0.1
Medication: Seretide 50 evohaler	0.5	0.6	1.5	1.2	-0.4	-0.3
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.5	-0.6	1.2	-0.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.3	0.6	0.4	1.1
Wears glasses or contact lenses	0.5	0.5	0.9	0.6	-0.9	-0.5
Alcohol drinker status: Previous	0.5	0.6	1.5	-1.2	0.1	-0.4
Bipolar Disorder (2018)	0.4	0.6	1.0	-0.9	1.0	0.3
Crohns Disease (2017)	0.4	0.9	1.5	1.2	-0.9	-0.5
Neuroticism (2016)	0.4	0.6	1.8	-0.3	0.1	1.3
Hand grip strength (right)	0.4	1.0	2.6	-0.5	1.6	0.3
Had menopause	0.4	0.5	0.9	0.3	-0.8	-0.9
Allergy	0.4	0.8	1.8	0.8	-1.3	0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.0	0.6	-1.0	-0.7
Worry too long after embarrassment	0.4	0.6	1.5	0.5	0.3	1.2
Qualifications: College or University degree	0.4	1.3	2.1	1.4	-0.6	-1.2
Eye problems/disorders: None of the above	0.4	0.5	0.7	-0.8	0.2	-0.8
Medication: Ibuprofen	0.4	0.5	0.8	0.0	0.9	0.9
Alcohol intake frequency.	0.4	0.9	1.5	0.0	1.2	1.1
Number of full sisters	0.4	0.5	0.8	0.6	-0.9	-0.5
Medication: Aspirin	0.4	0.6	1.2	1.1	-0.7	-0.1
Illnesses of siblings: Diabetes	0.4	0.5	0.8	-0.5	-0.8	-0.9
Mineral and other dietary supplements	0.4	0.5	1.1	-1.0	0.4	0.6
Medication: Atorvastatin	0.4	0.5	1.2	-0.3	-0.2	1.1
Irritability	0.4	0.7	1.5	-1.2	0.4	0.8
Ever depressed for a whole week	0.4	0.5	0.6	-0.7	-0.6	-0.7
Myopia	0.4	0.5	1.3	-0.3	0.4	1.1
Pain experienced in last month	0.4	0.6	1.3	0.5	-1.2	-0.6
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	-0.1	0.6	1.0
Neuroticism (Nagel 2018)	0.3	0.7	1.1	-0.6	0.7	1.0
Ulcerative Colitis (UC)	0.3	0.6	1.3	-0.2	1.1	0.7
Bipolar Disorder (2011)	0.3	0.3	0.5	0.5	-0.0	-0.7
Fasting Glucose	0.3	0.4	0.6	0.7	-0.8	-0.3
Blood Platelet Count	0.3	3.2	6.4	-0.8	1.6	2.5
Smoking Status	0.3	0.6	1.3	0.1	0.7	1.1
Lung FVC	0.3	1.5	2.7	-1.3	1.6	0.3
Tanning	0.3	3.6	4.9	-1.8	2.2	1.6
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	-0.6	0.8	0.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.8	0.1	-0.2	0.9
Severe depression (siblings)	0.3	0.3	0.6	-0.8	0.1	-0.5
Average weekly fortified wine intake	0.3	0.3	0.8	-0.9	0.2	-0.4
Maternal smoking around birth	0.3	0.4	0.5	0.6	0.7	0.6
Qualifications: CSEs or equivalent	0.3	0.4	0.8	0.2	-0.9	-0.6
Worrier / anxious feelings	0.3	0.5	1.1	-0.6	-0.3	-1.0
Falls in the last year	0.3	0.4	1.1	-1.0	0.1	0.0
Prospective memory result	0.3	0.3	0.5	0.4	0.7	0.5
Lung cancer (father)	0.3	0.3	0.9	-0.9	-0.3	-0.3
Pulse wave Arterial Stiffness index	0.3	0.4	0.7	0.3	-0.7	-0.8
Loud music exposure frequency	0.3	0.4	0.7	0.9	-0.5	-0.2
Birth weight	0.3	0.7	1.1	0.2	-0.9	-1.1
Pulse wave peak to peak time	0.3	0.3	0.5	-0.1	0.6	0.7
Mean time to correctly identify matches	0.3	0.6	1.6	0.1	0.5	1.3
Leg pain on walking	0.3	0.4	1.0	1.0	0.3	-0.0
Ever taken oral contraceptive pill	0.3	0.4	0.7	-0.2	0.6	0.9
Illnesses of father: High blood pressure	0.3	0.4	0.5	-0.7	0.7	0.4
Schizophrenia (2018)	0.2	0.4	0.6	-0.2	0.8	0.7
Coronary Artery Disease (CAD)	0.2	0.2	0.3	-0.6	0.5	0.3
Height	0.2	4.0	11.4	3.4	0.5	-0.5
Hand grip strength (left)	0.2	0.5	1.0	-0.3	1.0	-0.6
Age when periods started (menarche)	0.2	0.4	0.8	0.4	-0.9	-0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.4	-0.6	0.6	-0.1
Medication: Atenolol	0.2	0.2	0.4	0.2	-0.4	0.7
Qualifications: None of the above	0.2	0.4	1.2	-0.2	-0.3	1.1
Alcohol intake versus 10 years previously	0.2	0.3	0.4	0.6	0.3	0.6
Standing height	0.2	1.5	3.8	1.9	0.5	-0.7
Length of working week for main job	0.2	0.2	0.6	0.8	0.3	0.2
Exposure to tobacco smoke at home	0.2	0.3	0.4	-0.7	0.0	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.5	-0.1	-0.6	-0.7
Birth weight of first child	0.2	0.4	0.8	-0.5	0.9	0.4
Blood clot in the leg (DVT)	0.2	0.3	0.4	-0.4	0.7	0.4
Emphysema/chronic bronchitis	0.2	0.2	0.6	-0.8	0.2	-0.1
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	0.8	-0.1	0.6
Neck or shoulder pain in last month	0.2	0.3	0.6	-0.4	0.2	0.8
Comparative height size at age 10	0.2	1.1	2.2	1.0	-0.3	-1.5
Age at last live birth	0.2	0.2	0.5	0.3	-0.4	-0.7
Family relationship satisfaction	0.2	0.3	0.7	-0.3	0.2	0.8
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	-0.6	-0.2	-0.5
Medication: Bendroflumethiazide	0.2	0.3	0.8	0.9	0.0	0.5
Number of operations (self-reported)	0.2	0.3	0.8	0.9	-0.2	0.3
Unable to work because of sickness or disability	0.2	0.3	0.9	0.1	0.2	0.9
Depression (Nagel 2018)	0.1	0.2	0.4	-0.2	0.6	0.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.7	0.8	-0.2	-0.2
Major Depression (MDD)	0.1	0.1	0.1	0.0	0.2	0.4
Age at First Birth	0.1	0.1	0.3	0.5	0.2	0.1
Primary Biliary Cirrhosis	0.1	0.2	0.2	-0.4	0.4	0.5
Ulcerative Colitis	0.1	0.1	0.2	0.4	0.4	-0.0
Blood Red Count	0.1	0.8	1.1	-0.6	1.0	1.0
Systolic Blood Pressure	0.1	0.3	0.7	0.5	-0.8	-0.2
Respiratory disease	0.1	0.3	0.5	-0.1	0.6	0.7
Lung FEV1/FVC ratio	0.1	0.4	1.0	-1.0	-0.2	-0.0
Chronotype (morning person)	0.1	0.2	0.5	-0.1	-0.2	0.7
Angina	0.1	0.1	0.2	0.1	-0.4	0.4
Diabetes (father)	0.1	0.1	0.4	-0.1	0.6	0.0
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.1	0.5	0.2
Sitting height	0.1	0.9	2.0	1.4	0.7	0.4
High blood pressure (mother)	0.1	0.2	0.3	-0.6	0.1	0.4
Heart attack	0.1	0.2	0.4	0.6	-0.3	-0.0
Asthma	0.1	0.3	0.6	0.8	-0.3	0.1
Hair/balding pattern: Pattern 4	0.1	0.1	0.2	0.4	-0.3	-0.4
Peak expiratory flow (PEF)	0.1	0.3	0.5	-0.6	0.7	0.2
Gout (self-reported)	0.1	0.1	0.2	0.3	-0.4	-0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.5	-0.0	0.2
Comparative body size at age 10	0.1	0.4	0.6	0.7	0.3	0.8
Wheeze or whistling in the chest in last year	0.1	0.3	0.6	0.3	-0.2	0.8
Angina (self-reported)	0.1	0.1	0.3	-0.1	-0.3	0.5
Migraine (self-reported)	0.1	0.2	0.2	0.4	-0.4	-0.4
Suffer from ‘nerves’	0.1	0.2	0.2	-0.5	0.1	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.4	-0.2	0.6	0.2
Mood swings	0.1	0.3	0.5	0.5	0.3	0.7
Ever had bowel cancer screening	0.1	0.1	0.4	-0.0	-0.6	0.2
Asthma (self-reported)	0.1	0.2	0.5	0.7	-0.3	0.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	0.2	0.4	-0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	0.6	-0.3	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.3	-0.4	0.6	0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.1	0.2	0.0	0.3	0.4
Triglycerides	0.0	0.0	0.0	-0.0	-0.1	-0.0
Blood White Count	0.0	0.3	0.7	-0.1	0.4	0.8
Hair Pigment	0.0	1.3	2.7	-0.8	1.6	0.7
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.1	-0.1	-0.2
Mother’s age at death	0.0	0.0	0.1	-0.1	-0.3	0.2
Medication: Lisinopril	0.0	0.1	0.1	0.3	-0.2	-0.1

Hub : Genes

HIP1R

Models

Trait associations