Hub : Genes

HIP1R

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.058 0.031 3.6e-03 0.021 0.013 0.037 0.019 0.038 1.1e-03 0.0081 2.4e-05 0.0019 1.9e-05
2 GTEx Esophagus Mucosa 0.214 0.072 5.7e-06 0.049 NA 0.055 NA 0.072 3.1e-04 NA 1.5e-04 NA 1.5e-05
3 GTEx Skin Sun Exposed Lower leg 0.092 0.031 6.5e-05 0.115 NA 0.093 NA 0.110 8.8e-10 NA 4.2e-08 NA 2.1e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.4 0.6 1.0 -0.9 1.0 0.3
Bipolar Disorder or Schizophrenia 0.5 1.2 2.4 -0.8 1.5 0.7
Depressed Affect (Nagel 2018) 1.6 3.3 4.1 -1.6 1.8 2.0
Depression (Nagel 2018) 0.1 0.2 0.4 -0.2 0.6 0.3
Intelligence (Savage-Jansen 2018) 1.8 5.4 8.7 2.5 -3.0 -1.1
Neuroticism (Nagel 2018) 0.3 0.7 1.1 -0.6 0.7 1.0
Schizophrenia (2018) 0.2 0.4 0.6 -0.2 0.8 0.7
Schizophrenia vs Biploar Disorder 1.0 1.3 1.9 1.4 -1.2 -0.8
Worry (Nagel 2018) 0.6 1.2 1.7 0.9 -1.3 -1.1
Alzheimer’s Disease (in mother) 6.5 7.6 11.6 2.2 -3.4 -2.5
Alzheimer’s Disease (in father) 2.2 2.3 5.3 0.5 -1.2 -2.3
Alzheimer’s Disease (including proxy) 4.0 5.8 8.8 1.8 -2.3 -3.0
Crohns Disease (2017) 0.4 0.9 1.5 1.2 -0.9 -0.5
Irritable Bowel Disease (IBD) 0.1 0.2 0.7 0.8 -0.2 -0.2
Ulcerative Colitis (UC) 0.3 0.6 1.3 -0.2 1.1 0.7
Major Depression (MDD) 0.1 0.1 0.1 0.0 0.2 0.4
Reaction Time 1.5 2.9 4.0 -1.0 2.0 1.9
Verbal and Numeric Reasoning (VNR) 2.3 5.5 10.1 2.3 -3.2 -1.1
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 1.2 1.6 2.6 -0.8 1.2 1.6
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.1 0.1 0.3 0.5 0.2 0.1
Bipolar Disorder (2011) 0.3 0.3 0.5 0.5 -0.0 -0.7
Body Mass Index (BMI) (2010) 0.7 1.0 1.9 -0.9 1.4 0.5
Coronary Artery Disease (CAD) 0.2 0.2 0.3 -0.6 0.5 0.3
Crohns Disease (2012) 1.5 2.4 5.1 2.3 -1.4 -0.6
Mean Putamen Volume 1.2 1.3 1.5 -1.2 1.1 1.2
Fasting Glucose 0.3 0.4 0.6 0.7 -0.8 -0.3
HbA1C 3.1 3.4 5.6 -2.4 2.0 0.9
HDL Cholesterol 3.7 6.2 9.8 -3.1 2.3 1.8
LDL Cholesterol 0.8 1.3 3.3 -1.8 0.7 0.3
Lupus 2.3 3.4 4.9 -2.2 1.3 1.9
Neuroticism (2016) 0.4 0.6 1.8 -0.3 0.1 1.3
Primary Biliary Cirrhosis 0.1 0.2 0.2 -0.4 0.4 0.5
Rheumatoid Arthritis 1.8 2.4 3.4 -1.0 1.7 1.8
Schizophrenia (2014) 0.0 0.1 0.2 0.0 0.3 0.4
Triglycerides 0.0 0.0 0.0 -0.0 -0.1 -0.0
Type 2 Diabetes (T2D) (2012) 0.8 1.0 1.4 -1.0 1.2 0.7
Ulcerative Colitis 0.1 0.1 0.2 0.4 0.4 -0.0
Blood Eosinophil Count 1.3 10.3 13.2 -3.1 3.6 2.9
Blood Platelet Count 0.3 3.2 6.4 -0.8 1.6 2.5
Blood Red Count 0.1 0.8 1.1 -0.6 1.0 1.0
Blood White Count 0.0 0.3 0.7 -0.1 0.4 0.8
Heel T-Score 1.7 13.1 18.5 -4.3 3.3 3.1
BMI 7.0 40.8 70.2 -6.2 8.4 3.8
Height 0.2 4.0 11.4 3.4 0.5 -0.5
Waist Hip Ratio (WHR) 4.9 22.1 35.9 6.0 -5.0 -2.3
Systolic Blood Pressure 0.1 0.3 0.7 0.5 -0.8 -0.2
Smoking Status 0.3 0.6 1.3 0.1 0.7 1.1
Allergy or Eczema 0.7 1.9 2.9 -1.7 1.7 -0.2
Cardiovascular Disease 3.0 10.0 11.7 -2.7 3.3 3.4
Hypothyroidism (self reported) 0.7 1.5 1.7 -1.2 1.3 1.1
Respiratory disease 0.1 0.3 0.5 -0.1 0.6 0.7
Type 2 Diabetes (T2D) (2018) 6.3 11.8 13.7 -3.0 3.7 3.5
Lung FEV1/FVC ratio 0.1 0.4 1.0 -1.0 -0.2 -0.0
Lung FVC 0.3 1.5 2.7 -1.3 1.6 0.3
Neuroticism 0.7 1.7 2.8 -1.7 1.0 1.1
Chronotype (morning person) 0.1 0.2 0.5 -0.1 -0.2 0.7
Hair Pigment 0.0 1.3 2.7 -0.8 1.6 0.7
Tanning 0.3 3.6 4.9 -1.8 2.2 1.6
Hand grip strength (left) 0.2 0.5 1.0 -0.3 1.0 -0.6
Number of treatments/medications taken 3.1 5.6 6.1 -2.1 2.5 2.5
Average weekly spirits intake 1.2 1.4 2.6 -1.1 1.6 0.7
Sensitivity / hurt feelings 0.9 1.5 3.3 -0.3 1.0 1.8
Frequency of depressed mood in last 2 weeks 0.9 1.3 1.4 -1.2 1.0 1.2
Hearing difficulty/problems: Yes 1.7 2.6 4.0 2.0 -1.7 -0.9
Relative age of first facial hair 1.1 2.2 3.1 1.5 -1.2 -1.8
Other serious medical condition/disability diagnosed by doctor 1.8 2.3 3.6 0.3 1.8 1.9
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.7 -0.6 0.8 0.0
Ever had hysterectomy (womb removed) 2.5 2.8 4.8 -2.2 1.6 1.1
Systolic blood pressure, automated reading 0.5 1.4 2.0 -1.2 1.4 0.9
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.8 0.1 -0.2 0.9
Angina 0.1 0.1 0.2 0.1 -0.4 0.4
Medication for hormone replacement therapy 5.5 6.2 8.2 -1.5 2.8 2.9
Vitamin and mineral supplements 1.0 1.4 2.4 -0.4 -1.2 -1.6
Supplements: Zinc 0.5 0.5 1.2 0.4 0.5 1.1
Medication: Co-codamol 3.2 3.7 6.9 -1.7 2.6 1.1
Medication: Metformin 7.0 9.9 11.6 -3.4 3.1 2.9
Diabetes (father) 0.1 0.1 0.4 -0.1 0.6 0.0
Diabetes (mother) 1.5 2.0 4.3 -0.6 -1.1 -2.1
Severe depression (siblings) 0.3 0.3 0.6 -0.8 0.1 -0.5
Pack years adult smoking proportion 1.3 2.0 3.7 0.5 1.5 1.9
Impedance of leg (right) 0.9 4.5 7.7 2.1 -2.8 -1.1
Leg fat-free mass (left) 3.5 18.4 36.3 -3.5 6.0 2.6
Trunk fat percentage 8.0 32.0 53.0 -5.2 7.3 4.0
Hand grip strength (right) 0.4 1.0 2.6 -0.5 1.6 0.3
Townsend deprivation index at recruitment 0.5 0.7 1.7 0.3 -0.4 1.3
Current tobacco smoking 1.4 2.3 4.7 -0.9 1.2 2.2
Average weekly fortified wine intake 0.3 0.3 0.8 -0.9 0.2 -0.4
Maternal smoking around birth 0.3 0.4 0.5 0.6 0.7 0.6
Fed-up feelings 2.4 4.4 5.5 -2.1 2.4 1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.1 2.8 -1.3 1.7 1.3
Relative age voice broke 1.1 1.7 4.5 2.1 -0.5 -0.4
Taking other prescription medications 5.0 7.8 8.8 -2.8 3.0 2.6
Age when periods started (menarche) 0.2 0.4 0.8 0.4 -0.9 -0.6
Bilateral oophorectomy (both ovaries removed) 2.0 2.3 3.6 -1.9 1.5 1.0
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.5 4.3 -2.1 1.9 1.6
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 2.3 -1.5 0.7 0.9
Qualifications: CSEs or equivalent 0.3 0.4 0.8 0.2 -0.9 -0.6
Serious illness, injury or assault to yourself 0.1 0.1 0.2 0.1 0.5 0.2
High blood pressure 2.2 6.3 6.5 -2.5 2.5 2.5
Hayfever, allergic rhinitis or eczema 1.0 2.1 4.2 -1.5 2.1 -0.1
Multivitamins +/- minerals 0.7 0.9 1.5 0.2 1.1 1.2
Stomach or abdominal pain in last month 1.8 2.3 2.7 -1.6 1.6 1.3
Supplements: Glucosamine 0.9 1.2 2.5 -1.0 1.6 0.4
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.4 -0.6 0.6 -0.1
Medication: Atenolol 0.2 0.2 0.4 0.2 -0.4 0.7
Medication: Levothyroxine sodium 1.4 2.4 3.0 -1.7 1.2 1.7
Sitting height 0.1 0.9 2.0 1.4 0.7 0.4
Chronic bronchitis/emphysema (father) 1.7 2.0 3.7 -1.0 1.2 1.9
High blood pressure (mother) 0.1 0.2 0.3 -0.6 0.1 0.4
Body mass index (BMI) 9.2 39.0 59.1 -6.4 7.7 4.1
Impedance of leg (left) 0.9 4.2 7.7 1.9 -2.8 -1.2
Leg predicted mass (left) 3.4 18.2 35.9 -3.4 6.0 2.7
Trunk fat mass 8.4 35.9 61.8 -5.4 7.9 4.0
Waist circumference 4.2 15.3 26.4 -3.2 5.1 3.1
Number of incorrect matches in round 0.8 1.2 1.5 -1.2 0.9 1.2
Past tobacco smoking 0.8 1.5 2.6 -1.0 1.6 1.0
Alcohol usually taken with meals 0.5 0.8 1.2 -0.5 -1.0 -1.1
Nervous feelings 1.2 2.2 4.0 1.0 -2.0 -1.3
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 2.9 -1.0 1.0 1.7
Hearing difficulty/problems with background noise 1.0 1.6 3.1 1.2 -1.8 -0.6
Hair/balding pattern: Pattern 2 0.6 0.7 1.6 1.3 -0.7 0.0
Had menopause 0.4 0.5 0.9 0.3 -0.8 -0.9
Had other major operations 0.6 0.8 1.3 1.2 -0.8 -0.5
Forced vital capacity (FVC) 0.7 2.6 6.3 -1.3 2.5 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 2.0 4.6 6.7 -2.6 1.9 1.9
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 1.3 -1.1 -0.7 -0.8
Qualifications: None of the above 0.2 0.4 1.2 -0.2 -0.3 1.1
Financial difficulties in last 2 years 2.6 3.5 5.4 -1.2 2.3 2.0
Mouth/teeth dental problems 5.6 8.6 13.0 -3.4 3.6 1.2
Heart attack 0.1 0.2 0.4 0.6 -0.3 -0.0
Allergy 0.4 0.8 1.8 0.8 -1.3 0.1
Pain all over the body in last month 0.8 0.8 2.3 1.5 0.3 0.3
Diabetes (self-reported) 6.8 10.5 12.3 -2.7 3.4 3.5
Hayfever/allergic rhinitis (self-reported) 2.3 3.1 5.3 -2.3 1.7 0.9
Medication: Ramipril 2.0 2.6 4.6 -0.7 1.7 2.2
Medication: Simvastatin 1.7 2.5 4.5 -0.7 1.6 2.1
Fluid intelligence score 1.0 2.1 3.5 1.4 -1.9 -0.9
Illnesses of siblings 1.6 2.2 2.6 1.3 -1.6 -1.6
Neuroticism score 0.8 1.7 2.2 -1.5 1.1 1.3
Weight 6.6 32.5 57.0 -5.2 7.5 3.6
Impedance of arm (right) 0.6 2.6 5.7 2.4 -1.4 -0.4
Arm fat percentage (right) 8.1 32.0 52.9 -5.5 7.3 3.6
Trunk fat-free mass 1.0 6.0 13.3 -1.8 3.6 1.1
Hip circumference 9.0 38.8 61.0 -5.9 7.8 4.5
Time employed in main current job 1.3 1.4 2.8 -0.3 1.7 1.2
Alcohol intake versus 10 years previously 0.2 0.3 0.4 0.6 0.3 0.6
Father’s age at death 4.5 6.0 9.2 2.3 -3.0 -1.9
Worrier / anxious feelings 0.3 0.5 1.1 -0.6 -0.3 -1.0
Frequency of tiredness / lethargy in last 2 weeks 3.1 5.0 6.1 -2.5 2.3 1.9
Falls in the last year 0.3 0.4 1.1 -1.0 0.1 0.0
Hair/balding pattern: Pattern 3 0.6 0.9 1.2 -1.1 1.1 0.6
Number of live births 0.7 0.9 1.3 -0.6 -1.1 -1.1
Forced expiratory volume in 1-second (FEV1) 1.1 3.6 6.4 -2.1 2.5 0.0
Pulse rate 4.3 7.3 11.8 -3.4 3.1 0.5
Happiness 0.8 1.0 2.1 -1.5 0.4 0.8
Noisy workplace 2.4 3.0 6.7 0.3 1.5 2.6
Qualifications: A levels/AS levels or equivalent 0.7 1.4 1.8 1.2 -1.3 -1.1
Serious illness, injury or assault of a close relative in last 2 years 2.9 3.3 4.8 -1.6 1.7 2.2
Mouth/teeth dental problems: Dentures 1.1 1.8 2.8 1.7 -1.6 -0.2
Asthma 0.1 0.3 0.6 0.8 -0.3 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.2 2.1 -0.6 1.4 1.0
Medication: Cholesterol lowering 3.8 6.0 8.3 -1.6 2.7 2.9
Depression (self-reported) 1.9 2.3 3.5 -1.9 1.6 1.0
Medication: Lansoprazole 0.5 0.6 0.9 -0.9 0.9 -0.4
Prospective memory result 0.3 0.3 0.5 0.4 0.7 0.5
Lung cancer (father) 0.3 0.3 0.9 -0.9 -0.3 -0.3
Illnesses of mother 0.8 0.9 2.0 -0.0 0.9 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.0 7.6 -2.0 2.8 0.7
Pulse wave Arterial Stiffness index 0.3 0.4 0.7 0.3 -0.7 -0.8
Impedance of arm (left) 0.6 2.7 5.1 2.2 -1.7 -0.5
Arm fat mass (right) 8.4 34.7 58.6 -5.7 7.7 3.6
Trunk predicted mass 1.1 6.3 13.8 -1.9 3.7 1.2
Standing height 0.2 1.5 3.8 1.9 0.5 -0.7
Length of working week for main job 0.2 0.2 0.6 0.8 0.3 0.2
Exposure to tobacco smoke at home 0.2 0.3 0.4 -0.7 0.0 -0.6
Breastfed as a baby 2.2 2.7 3.8 2.0 -1.8 -1.0
Tense / ‘highly strung’ 0.5 0.8 1.0 -1.0 0.9 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.5 -0.1 -0.6 -0.7
Hair/balding pattern: Pattern 4 0.1 0.1 0.2 0.4 -0.3 -0.4
Birth weight of first child 0.2 0.4 0.8 -0.5 0.9 0.4
Peak expiratory flow (PEF) 0.1 0.3 0.5 -0.6 0.7 0.2
Pulse wave reflection index 2.7 3.4 3.8 1.9 -1.9 -1.7
Ever highly irritable/argumentative for 2 days 1.1 1.4 3.3 -1.8 0.9 0.1
Loud music exposure frequency 0.3 0.4 0.7 0.9 -0.5 -0.2
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.0 0.6 -1.0 -0.7
Mouth/teeth dental problems: Bleeding gums 3.1 4.0 5.2 1.9 -2.3 -1.8
Blood clot in the leg (DVT) 0.2 0.3 0.4 -0.4 0.7 0.4
Medication: Paracetamol 0.6 1.1 2.1 -0.7 -0.8 -1.4
Headache pain in last month 2.5 4.3 7.4 1.1 -2.7 -2.1
Medication for cholesterol, blood pressure or diabetes 1.7 2.9 4.3 0.9 -1.9 -2.1
Glaucoma (self-reported) 1.0 1.2 3.2 1.8 -0.5 0.4
Gout (self-reported) 0.1 0.1 0.2 0.3 -0.4 -0.4
Hypothyroidism/myxoedema (self-reported) 0.5 1.1 1.3 -1.1 0.8 1.1
Medication: Amlodipine 2.9 4.0 4.5 -1.8 2.0 2.1
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 0.5 -0.0 0.2
Birth weight 0.3 0.7 1.1 0.2 -0.9 -1.1
Chronic bronchitis/emphysema (mother) 1.0 1.1 1.6 -1.3 1.1 0.8
High blood pressure (siblings) 1.4 2.0 3.2 -0.9 1.4 1.8
Forced vital capacity (FVC), Best measure 1.0 3.7 8.3 -1.5 2.9 0.8
Body fat percentage 8.7 34.5 56.4 -5.6 7.5 4.0
Leg fat percentage (right) 9.1 33.1 49.8 -6.0 7.1 3.6
Arm fat-free mass (right) 2.3 11.8 21.6 -3.1 4.7 2.0
Exposure to tobacco smoke outside home 0.5 0.7 1.9 1.4 -0.2 0.1
Comparative body size at age 10 0.1 0.4 0.6 0.7 0.3 0.8
Number of full brothers 0.7 0.9 1.6 1.0 -1.3 -0.3
Worry too long after embarrassment 0.4 0.6 1.5 0.5 0.3 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.1 3.3 -1.8 1.6 0.7
Wheeze or whistling in the chest in last year 0.1 0.3 0.6 0.3 -0.2 0.8
Number of children fathered 1.6 1.8 2.6 1.6 -1.3 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.9 1.3 -0.2 1.1 1.1
Age at first live birth 0.7 1.2 2.6 0.6 -0.8 -1.6
Pulse wave peak to peak time 0.3 0.3 0.5 -0.1 0.6 0.7
Health satisfaction 2.1 2.8 3.7 -1.9 1.6 1.4
Shortness of breath walking on level ground 2.1 2.5 3.2 -1.6 1.8 1.3
Qualifications: College or University degree 0.4 1.3 2.1 1.4 -0.6 -1.2
Eye problems/disorders: None of the above 0.4 0.5 0.7 -0.8 0.2 -0.8
Mouth/teeth dental problems: Loose teeth 3.3 4.0 6.8 2.1 -2.6 -0.9
Emphysema/chronic bronchitis 0.2 0.2 0.6 -0.8 0.2 -0.1
Medication for pain relief, constipation, heartburn 0.2 0.3 0.7 0.8 -0.1 0.6
Neck or shoulder pain in last month 0.2 0.3 0.6 -0.4 0.2 0.8
Medication: Blood pressure 0.9 1.6 3.1 0.4 1.3 1.8
Angina (self-reported) 0.1 0.1 0.3 -0.1 -0.3 0.5
Migraine (self-reported) 0.1 0.2 0.2 0.4 -0.4 -0.4
Medication: Ibuprofen 0.4 0.5 0.8 0.0 0.9 0.9
Medication: Allopurinol 0.6 0.7 1.3 0.9 -1.1 -0.3
Medication: Omeprazole 1.1 1.3 2.4 -1.5 1.2 0.5
Medication: Seretide 50 evohaler 0.5 0.6 1.5 1.2 -0.4 -0.3
Mean time to correctly identify matches 0.3 0.6 1.6 0.1 0.5 1.3
Heart disease (mother) 2.8 3.4 5.6 -0.6 2.0 2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 1.8 0.7 -1.0 -1.3
Whole body fat mass 9.0 37.7 63.7 -5.8 8.0 4.1
Leg fat mass (right) 9.7 37.7 61.7 -6.1 7.9 3.8
Arm predicted mass (right) 2.5 12.5 22.5 -3.3 4.7 2.0
Pulse rate, automated reading 5.5 17.7 26.2 -4.8 5.1 2.0
Alcohol intake frequency. 0.4 0.9 1.5 0.0 1.2 1.1
Comparative height size at age 10 0.2 1.1 2.2 1.0 -0.3 -1.5
Number of full sisters 0.4 0.5 0.8 0.6 -0.9 -0.5
Suffer from ‘nerves’ 0.1 0.2 0.2 -0.5 0.1 0.5
Overall health rating 2.1 4.4 7.7 -1.1 2.1 2.8
Chest pain or discomfort 0.8 1.2 2.3 1.5 -1.0 0.3
Had major operations 2.2 2.6 4.2 -2.0 1.4 1.3
Age at last live birth 0.2 0.2 0.5 0.3 -0.4 -0.7
Family relationship satisfaction 0.2 0.3 0.7 -0.3 0.2 0.8
Leg pain on walking 0.3 0.4 1.0 1.0 0.3 -0.0
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.4 -0.2 0.6 0.2
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.5 -0.6 1.2 -0.2
Illness, injury, bereavement, stress in last 2 years 2.5 3.0 3.9 1.2 -2.0 -1.9
Medication: Aspirin 0.4 0.6 1.2 1.1 -0.7 -0.1
Supplements: Vitamin C 0.7 0.9 1.3 -0.3 1.1 1.2
Knee pain experienced in last month 1.6 2.4 4.1 -1.3 2.0 1.2
Hypertension (Self-reported) 2.2 6.1 6.4 -2.4 2.5 2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 2.6 -1.6 -0.2 -0.9
Illnesses of father: Heart disease 1.4 1.9 3.4 -1.8 1.4 0.6
Illnesses of siblings: Diabetes 0.4 0.5 0.8 -0.5 -0.8 -0.9
Smoking status: Previous 1.8 2.7 3.5 1.9 -1.7 -1.3
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 2.9 1.7 -0.5 -0.9
Whole body fat-free mass 2.0 11.5 23.5 -2.7 4.8 1.9
Leg fat-free mass (right) 3.0 16.0 31.7 -3.2 5.6 2.5
Arm fat percentage (left) 8.9 35.4 56.7 -5.8 7.5 3.9
Average weekly red wine intake 0.9 1.3 2.6 -1.6 -0.7 -0.9
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.3 0.6 0.4 1.1
Mood swings 0.1 0.3 0.5 0.5 0.3 0.7
Loneliness, isolation 1.2 1.6 3.2 -0.3 1.2 1.8
Long-standing illness, disability or infirmity 4.2 6.4 8.6 -2.5 2.9 2.0
Ever had bowel cancer screening 0.1 0.1 0.4 -0.0 -0.6 0.2
Diabetes diagnosed by doctor 8.5 14.0 16.1 -3.7 4.0 3.5
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.2 -0.7 -0.5 -1.1
Friendships satisfaction 0.9 1.2 1.8 -1.4 0.5 1.2
Qualifications: nursing, teaching 0.8 1.3 2.8 1.7 -0.1 1.1
Commuting to job workplace: Walk 3.9 4.3 6.7 -1.7 1.8 2.6
Eye problems/disorders: Cataract 0.0 0.0 0.1 0.1 -0.1 -0.2
Mouth/teeth dental problems: Mouth ulcers 2.4 3.9 7.3 1.9 -2.7 -0.9
Medication for cholesterol 4.3 6.5 7.5 2.7 -2.5 -2.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 1.4 0.4 1.0 1.2
Back pain experienced in last month 2.0 3.0 4.9 -2.2 2.0 0.2
Mineral and other dietary supplements 0.4 0.5 1.1 -1.0 0.4 0.6
Breast cancer (self-reported) 1.6 1.9 3.1 0.1 -1.6 -1.7
Asthma (self-reported) 0.1 0.2 0.5 0.7 -0.3 0.0
Osteoporosis (self-reported) 0.7 0.9 1.7 -1.3 0.5 0.8
Osteoarthritis (self-reported) 1.6 2.1 3.2 -1.8 1.6 0.7
Medication: Aspirin 0.8 1.0 2.4 1.6 -0.8 0.1
Medication: Gliclazide 2.9 3.3 4.2 -1.3 2.0 2.0
Illnesses of father: None of the above (group 1) 2.7 3.3 4.5 2.1 -2.1 -1.1
Smoking status: Current 1.7 2.7 5.0 -1.2 1.4 2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.4 2.1 -1.4 1.4 -0.2
Whole body water mass 2.0 11.3 23.3 -2.7 4.8 1.9
Leg predicted mass (right) 3.0 15.8 31.2 -3.2 5.6 2.5
Arm fat mass (left) 8.4 34.6 57.0 -5.8 7.5 3.7
Number of self-reported non-cancer illnesses 3.1 5.4 6.3 -2.0 2.5 2.5
Average weekly champagne plus white wine intake 0.6 0.8 2.1 -0.1 -0.5 -1.4
Miserableness 2.0 3.4 5.1 -1.6 1.6 2.3
Guilty feelings 1.3 2.0 2.8 -1.5 1.0 1.7
Wears glasses or contact lenses 0.5 0.5 0.9 0.6 -0.9 -0.5
Ever taken oral contraceptive pill 0.3 0.4 0.7 -0.2 0.6 0.9
Hearing aid user 3.1 3.5 5.0 0.7 -2.2 -2.2
Mother’s age at death 0.0 0.0 0.1 -0.1 -0.3 0.2
Financial situation satisfaction 2.3 2.9 4.2 -1.5 1.5 2.0
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.4 -0.6 -0.2 -0.5
Commuting to job workplace: Public transport 1.5 1.8 3.6 1.9 -1.3 -0.5
Eye problems/disorders: Glaucoma 0.7 0.9 2.0 1.4 -0.3 0.7
Medication: Blood pressure 1.1 2.2 5.5 -2.3 0.9 0.5
Pain type(s) experienced in last month: Hip pain 2.9 3.7 5.0 -1.1 2.2 2.2
Supplements: Fish oil (including cod liver oil) 1.0 1.4 1.7 1.3 -1.0 -1.2
High cholesterol (Self-reported) 3.6 6.3 12.2 -1.5 2.1 3.5
Medication: Bendroflumethiazide 0.2 0.3 0.8 0.9 0.0 0.5
Medication: Paracetamol 1.0 1.6 3.1 -0.3 -1.3 -1.7
Medication: Lisinopril 0.0 0.1 0.1 0.3 -0.2 -0.1
Medication: Atorvastatin 0.4 0.5 1.2 -0.3 -0.2 1.1
Illnesses of father: High blood pressure 0.3 0.4 0.5 -0.7 0.7 0.4
Alcohol drinker status: Never 1.0 1.2 1.6 -0.9 1.3 1.1
Ever smoked 1.3 2.4 4.4 1.2 -2.1 -1.1
Basal metabolic rate 3.0 16.7 32.8 -3.4 5.7 2.4
Leg fat percentage (left) 8.7 31.6 47.5 -5.9 6.9 3.5
Arm fat-free mass (left) 2.7 13.5 25.2 -3.2 5.0 2.2
Number of operations (self-reported) 0.2 0.3 0.8 0.9 -0.2 0.3
Average weekly beer plus cider intake 0.8 1.2 1.4 -0.9 1.2 1.1
Irritability 0.4 0.7 1.5 -1.2 0.4 0.8
Risk taking 2.4 3.5 4.4 -2.1 2.0 1.3
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 0.2 0.4 -0.2
Fractured/broken bones in last 5 years 3.3 4.3 5.7 2.2 -2.4 -1.5
Age started oral contraceptive pill 2.6 3.2 5.8 0.9 -2.4 -1.7
Diastolic blood pressure, automated reading 7.1 21.9 29.2 -4.8 5.4 3.6
Ever depressed for a whole week 0.4 0.5 0.6 -0.7 -0.6 -0.7
Unable to work because of sickness or disability 0.2 0.3 0.9 0.1 0.2 0.9
Commuting to job workplace: Cycle 3.4 4.1 7.1 2.0 -2.7 -1.1
Myopia 0.4 0.5 1.3 -0.3 0.4 1.1
Vascular/heart problems diagnosed by doctor 1.7 4.5 6.9 1.5 -2.1 -2.6
Cholesterol lowering medication 0.9 1.3 2.6 -1.6 0.5 1.1
Medication: Omeprazole (e.g. Zanprol) 1.5 1.9 5.0 -2.2 0.7 -0.3
Pain experienced in last month 0.4 0.6 1.3 0.5 -1.2 -0.6
Supplements: Calcium 1.6 1.8 3.8 1.9 -1.2 0.2
Basal cell carcinoma (self-reported) 0.4 0.5 1.0 -0.1 0.6 1.0
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.4 0.6 -0.3 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.3 -0.4 0.6 0.1
Heart disease (siblings) 1.4 1.7 2.4 -0.7 1.5 1.5
Alcohol drinker status: Previous 0.5 0.6 1.5 -1.2 0.1 -0.4
Pack years of smoking 1.1 1.6 2.8 0.6 1.2 1.7
Impedance of whole body 0.7 3.7 5.9 2.1 -2.4 -0.9
Leg fat mass (left) 9.5 37.3 60.8 -6.1 7.8 3.7
Arm predicted mass (left) 2.6 13.3 24.7 -3.3 5.0 2.1