TWAS hub - RILPL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.033	0.0150	1.3e-03	0.001	0.020	-0.002	0.015	-0.001	2.4e-01	1.5e-03	6.5e-01	4.7e-03	4.3e-01
2	GTEx	Spleen	0.316	0.1150	4.7e-03	0.034	NA	0.020	NA	0.031	4.7e-02	NA	1.0e-01	NA	5.6e-02
3	YFS	Blood	0.186	0.0443	3.7e-11	0.041	0.032	0.070	0.060	0.073	1.8e-13	7.4e-11	8.4e-22	4.6e-19	6.8e-23
4	TCGA	Pheochromocytoma and Paraganglioma	0.122	0.0670	5.1e-03	0.032	0.052	0.031	NA	0.040	1.9e-02	4.1e-03	2.2e-02	NA	1.1e-02
5	TCGA	Testicular Germ Cell Tumors	0.261	0.0910	2.9e-05	0.236	0.140	0.163	NA	0.150	7.5e-09	1.2e-05	2.2e-06	NA	5.9e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Sitting height	4.9	35.0	163.8	12.8	-2.7	-1.7	-0.9	-0.1
Qualifications: O levels/GCSEs or equivalent	4.4	7.0	25.1	5.0	-2.3	-1.5	-0.9	1.1
Financial difficulties in last 2 years	4.0	5.4	10.1	-2.1	2.4	0.2	3.2	-2.6
Allergy	4.0	9.2	19.4	4.4	-2.0	-0.5	-3.8	2.8
Comparative height size at age 10	3.9	21.3	100.0	10.0	-1.9	-1.3	-1.0	0.4
Medication: Seretide 50 evohaler	3.8	4.4	9.1	-0.1	2.1	2.1	3.0	-2.0
Height	3.6	69.0	306.7	17.5	-4.7	-3.2	-1.8	1.8
Lung cancer (father)	3.5	4.1	13.3	0.1	-3.6	-0.5	-1.9	1.8
Knee pain experienced in last month	3.3	5.1	10.0	-2.2	1.6	2.6	3.2	-1.3
Standing height	3.2	31.7	141.6	11.9	-2.4	-2.4	-1.8	1.4
Medication for pain relief, constipation, heartburn	3.2	5.5	17.4	4.2	-0.2	1.7	-2.7	0.1
Supplements: Zinc	3.1	3.4	7.1	0.5	-1.0	-2.3	-1.8	2.7
Hayfever, allergic rhinitis or eczema	3.1	6.7	14.3	-3.8	1.4	-0.3	3.3	-2.5
Glaucoma (self-reported)	3.0	3.5	6.8	-1.8	0.1	-1.6	-2.2	2.6
Allergy or Eczema	2.9	7.5	20.8	-4.6	1.3	0.1	3.0	-2.5
Average weekly red wine intake	2.9	4.3	17.2	4.1	-0.9	-1.5	0.9	-0.7
Leg fat percentage (left)	2.9	10.7	23.9	-4.9	1.6	2.6	2.3	-3.9
Age started oral contraceptive pill	2.9	3.6	9.2	1.6	-3.0	-0.2	-1.5	2.0
Ever had hysterectomy (womb removed)	2.8	3.2	7.2	-2.7	2.7	0.6	0.9	-0.3
Supplements: Calcium	2.8	3.1	5.1	2.2	-1.1	-0.9	-2.1	2.1
Leg fat percentage (right)	2.7	9.6	21.9	-4.7	1.5	2.7	1.8	-3.7
Diastolic blood pressure, automated reading	2.7	8.5	37.1	-6.1	1.8	-0.0	1.4	-0.4
Trunk fat-free mass	2.6	14.6	69.4	8.3	-0.2	1.0	0.6	-1.6
Trunk predicted mass	2.6	14.7	69.3	8.3	-0.3	1.1	0.6	-1.7
Bilateral oophorectomy (both ovaries removed)	2.5	2.9	4.4	-1.9	2.1	-0.8	2.0	-1.4
Hayfever/allergic rhinitis (self-reported)	2.5	3.3	10.8	-1.5	-1.1	-1.2	3.3	-0.8
Major Depression (MDD)	2.4	2.9	4.7	-2.1	-2.2	-1.7	-1.6	0.0
Heel T-Score	2.4	18.8	83.2	-9.1	-0.3	-1.6	-1.1	2.6
Qualifications: None of the above	2.4	5.1	23.6	-4.9	1.0	0.6	0.4	0.3
Reaction Time	2.3	4.4	10.8	-3.3	-1.2	-0.8	-2.0	2.3
Arm fat percentage (left)	2.3	9.3	21.6	-4.7	1.6	3.2	0.9	-3.4
Waist Hip Ratio (WHR)	2.2	9.7	34.5	-0.5	0.4	-3.7	0.0	5.9
Arm fat percentage (right)	2.2	8.8	20.6	-4.5	1.5	3.1	0.9	-3.3
Noisy workplace	2.2	2.8	6.8	-1.6	-0.4	-2.0	0.7	2.6
Ever highly irritable/argumentative for 2 days	2.2	2.6	6.2	-2.5	-0.3	-1.7	-0.3	2.0
Qualifications: College or University degree	2.2	7.0	31.2	5.6	0.1	-0.2	1.2	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.5	5.7	-1.2	2.4	0.2	1.5	-1.8
Respiratory disease	2.1	4.6	7.7	-2.0	2.0	2.2	2.8	-1.6
Arm fat-free mass (right)	2.1	10.9	46.2	6.8	-0.0	1.4	1.2	-2.3
Comparative body size at age 10	2.1	5.9	15.4	-0.9	0.9	3.0	1.9	-3.9
Arm fat-free mass (left)	2.1	10.5	44.0	6.6	-0.2	1.2	1.2	-2.3
Arm predicted mass (left)	2.1	10.8	44.3	6.7	0.0	1.3	1.4	-2.4
Body mass index (BMI)	2.0	8.6	17.7	-2.6	1.7	3.3	2.2	-4.2
Body fat percentage	2.0	7.9	18.6	-4.3	1.2	2.3	1.3	-3.5
Arm predicted mass (right)	2.0	10.1	45.1	6.7	-0.2	1.0	1.1	-1.8
Whole body fat-free mass	2.0	11.4	50.4	7.1	-0.3	1.3	0.6	-2.1
Back pain experienced in last month	2.0	2.9	10.2	-2.0	0.1	0.1	3.2	0.5
Whole body water mass	2.0	11.6	51.8	7.2	-0.3	1.4	0.6	-2.0
Deep venous thrombosis (DVT) (self-reported)	2.0	2.5	11.0	-3.3	0.6	0.9	-0.6	0.0
BMI	1.9	11.0	24.3	-3.4	1.5	3.5	2.1	-4.9
Maternal smoking around birth	1.9	2.8	5.9	0.0	0.9	-2.4	1.3	2.4
Alcohol usually taken with meals	1.9	3.1	11.8	3.4	-0.2	-0.7	1.5	-1.0
Medication: Paracetamol	1.9	3.2	11.2	-3.3	-0.3	-1.5	1.6	-0.1
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	3.5	1.8	-1.4	0.3	-1.9	1.6
Qualifications: nursing, teaching	1.9	2.9	9.4	3.1	-1.3	1.9	0.1	-0.0
Commuting to job workplace: Walk	1.9	2.1	5.3	-2.3	0.5	-0.5	1.8	-1.2
Supplements: Fish oil (including cod liver oil)	1.9	2.5	7.6	0.1	-0.9	-1.3	-1.5	2.8
Pain experienced in last month	1.9	3.2	7.7	2.8	0.1	-2.2	-1.8	-0.0
Primary Biliary Cirrhosis	1.8	2.6	8.6	2.9	-0.3	0.1	1.9	-0.8
Hip circumference	1.8	7.8	23.1	1.4	1.2	3.5	0.8	-4.8
Qualifications: A levels/AS levels or equivalent	1.8	4.0	18.5	4.3	0.0	0.6	-0.1	-1.0
Breastfed as a baby	1.8	2.2	9.5	3.1	-0.5	1.0	-0.6	-0.3
Family relationship satisfaction	1.8	2.2	7.1	0.5	-1.6	0.7	-2.7	0.6
Number of self-reported non-cancer illnesses	1.8	3.1	6.9	-2.2	0.7	-1.2	2.6	-1.4
Alcohol drinker status: Never	1.8	2.2	6.4	-2.5	0.9	1.5	-1.1	-0.1
Ovarian Cancer	1.7	2.2	5.3	-0.6	-0.4	1.4	-1.9	2.3
Lung FEV1/FVC ratio	1.7	8.6	16.2	-2.2	-2.5	-4.0	0.2	3.9
Medication: Co-codamol	1.7	2.0	5.2	-2.3	0.5	1.3	1.4	-0.9
Hand grip strength (right)	1.7	4.5	7.1	2.6	2.7	1.4	1.4	-2.2
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.8	11.2	-3.3	-0.3	-1.4	-0.2	2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	10.4	-3.2	0.0	-0.3	1.5	0.7
Number of children fathered	1.7	1.9	5.3	2.3	-0.8	-1.0	1.3	-1.0
Mean time to correctly identify matches	1.7	3.3	5.8	-2.0	-1.3	-1.3	-1.8	2.4
Alcohol intake frequency.	1.7	3.9	15.9	-4.0	-0.0	-0.2	-1.5	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	3.4	-1.8	-0.8	-1.9	-0.2	1.6
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	8.3	-1.5	-1.3	-0.6	-1.1	2.9
Medication: Paracetamol	1.7	2.7	6.1	-2.5	0.3	-1.5	2.2	-0.4
Ever smoked	1.7	2.9	13.8	3.7	0.1	-0.6	-0.3	0.6
Basal metabolic rate	1.7	9.5	38.9	6.2	-0.1	1.5	0.7	-2.4
Leg fat mass (left)	1.7	6.5	14.9	-2.3	1.3	2.7	1.7	-3.9
Medication: Simvastatin	1.6	2.3	7.2	0.7	-1.2	-2.7	0.8	1.4
Father’s age at death	1.6	2.1	6.2	2.0	-0.1	0.2	-2.5	0.3
Leg fat mass (right)	1.6	6.1	14.1	-2.1	1.3	2.9	1.4	-3.8
Asthma (self-reported)	1.6	3.1	9.2	-1.9	0.7	1.0	3.0	-1.1
Illnesses of father: High blood pressure	1.6	2.0	4.6	-2.1	1.6	0.7	-0.7	-1.3
Medication: Metformin	1.5	2.2	5.1	-2.0	0.4	-2.3	0.8	0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	10.3	-3.2	0.2	-1.3	-0.5	2.2
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	4.9	-2.2	0.3	-0.0	1.7	-1.3
Prospective memory result	1.5	1.8	3.4	-1.8	0.6	1.3	0.8	-1.7
Blood clot in the leg (DVT)	1.5	2.0	8.3	-2.9	0.5	1.0	-0.6	0.2
Chronic bronchitis/emphysema (mother)	1.5	1.7	4.2	-0.9	1.3	0.2	1.4	-2.0
Ever had bowel cancer screening	1.5	1.7	2.6	1.6	-1.5	-1.4	1.2	0.6
Financial situation satisfaction	1.5	1.8	3.4	-1.9	-0.8	-1.5	1.0	1.4
Fractured/broken bones in last 5 years	1.5	1.9	8.1	2.9	0.1	-0.3	0.8	-0.9
Lung FVC	1.4	7.1	29.7	-5.5	2.3	0.7	-0.1	0.2
Severe depression (siblings)	1.4	1.5	3.8	-0.2	0.8	1.7	0.4	-2.0
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	3.9	-0.6	-1.5	-2.0	-0.8	1.2
Depression (self-reported)	1.4	1.7	5.1	-2.3	-1.2	-0.6	0.7	1.1
Medication: Lansoprazole	1.4	1.6	3.9	-2.0	-1.1	-0.3	-0.2	1.6
Wheeze or whistling in the chest in last year	1.4	2.5	6.7	-1.6	2.6	0.4	1.4	-1.1
Emphysema/chronic bronchitis	1.4	1.6	4.2	-1.2	2.1	1.5	-0.3	-0.3
Number of full sisters	1.4	1.7	3.4	-0.9	0.0	-1.0	-1.8	1.9
Medication for cholesterol	1.4	2.1	8.1	0.3	-0.7	0.6	-2.9	1.2
Pain type(s) experienced in last month: Hip pain	1.4	1.7	7.1	0.1	0.6	0.9	2.7	-0.6
Schizophrenia vs Biploar Disorder	1.3	1.7	5.7	2.4	-0.4	-1.6	0.0	0.0
Irritable Bowel Disease (IBD)	1.3	3.1	5.7	1.8	1.3	0.4	2.2	-2.4
Ulcerative Colitis (UC)	1.3	2.5	5.7	0.7	1.0	-0.4	2.3	-2.4
Neuroticism (2016)	1.3	1.8	5.8	-0.6	0.5	1.6	2.4	-0.4
Type 2 Diabetes (T2D) (2012)	1.3	1.5	4.0	-2.0	1.9	-0.2	0.0	0.0
Blood Platelet Count	1.3	14.7	65.9	-8.1	-0.7	-2.2	0.8	1.2
Pack years adult smoking proportion	1.3	2.0	3.2	-1.7	1.8	1.6	-0.6	-1.2
Current tobacco smoking	1.3	2.1	8.7	-1.0	2.9	0.1	-0.7	-0.4
Fed-up feelings	1.3	2.4	7.0	-2.6	-0.2	0.3	2.0	-1.0
Medication: Levothyroxine sodium	1.3	2.1	5.3	2.3	1.5	0.9	0.6	-1.4
Had menopause	1.3	1.6	6.3	2.5	0.4	0.4	0.2	-1.1
Alcohol intake versus 10 years previously	1.3	2.0	4.6	-2.1	-0.3	-1.8	1.0	1.1
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	5.6	-2.4	1.4	1.6	0.8	-0.2
Illnesses of mother	1.3	1.6	3.5	0.5	-0.7	1.1	-1.9	1.6
Pulse wave Arterial Stiffness index	1.3	1.5	6.6	2.6	-0.3	-0.3	-0.2	0.8
Arm fat mass (right)	1.3	5.3	12.7	-1.3	1.3	3.0	1.4	-3.6
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	4.4	2.1	0.9	-0.5	1.2	-1.2
Leg fat-free mass (right)	1.3	7.0	28.4	5.3	-0.5	1.4	0.2	-2.1
Leg predicted mass (right)	1.3	6.8	27.9	5.3	-0.4	1.5	0.1	-2.0
Tinnitus: Yes, now most or all of the time	1.3	1.5	5.2	-2.3	0.2	-1.1	0.8	-0.6
Risk taking	1.3	1.9	3.7	0.3	1.7	-0.2	1.9	-1.6
Heart disease (siblings)	1.3	1.5	4.2	-2.0	1.2	0.6	1.2	0.4
Depressed Affect (Nagel 2018)	1.2	2.5	7.1	-2.7	-1.2	1.0	1.4	-1.2
Crohns Disease (2012)	1.2	1.9	5.9	1.6	0.9	2.4	0.0	0.0
Relative age of first facial hair	1.2	2.5	10.5	-3.2	0.6	0.4	1.0	-0.8
Trunk fat percentage	1.2	4.9	12.5	-3.5	0.3	1.8	0.7	-2.9
Leg predicted mass (left)	1.2	6.2	24.7	5.0	-0.5	1.5	-0.1	-1.9
Gout (self-reported)	1.2	1.6	4.5	2.1	0.6	-1.2	1.1	0.7
Illnesses of siblings: Diabetes	1.2	1.5	4.0	-1.4	-0.1	-2.0	0.6	1.0
Loneliness, isolation	1.2	1.6	2.3	-1.2	1.0	1.5	1.3	-1.2
Smoking status: Current	1.2	1.9	7.6	-1.1	2.8	-0.2	-0.6	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	8.1	-2.8	-0.4	0.4	1.4	-1.5
Arm fat mass (left)	1.2	5.1	12.4	-1.2	1.2	2.9	1.2	-3.5
Eye problems/disorders: Glaucoma	1.2	1.4	2.7	-0.6	-1.2	-1.5	-0.6	1.6
Bipolar Disorder or Schizophrenia	1.1	2.6	7.6	2.8	2.3	0.0	0.0	0.0
Intelligence (Savage-Jansen 2018)	1.1	3.3	6.5	2.4	1.6	2.5	-0.2	-1.5
Schizophrenia (2014)	1.1	2.4	10.5	3.2	1.0	-0.7	0.0	0.0
Neuroticism	1.1	2.7	7.3	-1.5	0.5	0.8	2.7	-1.8
Average weekly spirits intake	1.1	1.3	2.7	-1.5	-0.4	-0.0	1.6	-1.2
Leg fat-free mass (left)	1.1	6.0	24.0	4.9	-0.5	1.5	-0.1	-1.9
Relative age voice broke	1.1	1.7	7.6	-2.8	-0.6	0.6	0.0	-0.1
Serious illness, injury or assault to yourself	1.1	1.4	2.8	1.7	-0.7	-1.0	1.6	-0.2
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	5.0	-2.2	-0.3	0.3	-1.1	-0.3
Past tobacco smoking	1.1	2.1	8.1	-2.8	0.6	0.4	0.1	-1.4
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	5.4	-2.3	0.0	1.2	0.9	0.9
Pain all over the body in last month	1.1	1.2	2.5	-1.4	-0.2	1.6	-0.7	-1.0
Weight	1.1	5.3	11.5	3.0	0.5	1.9	1.4	-3.4
Asthma	1.1	2.1	6.2	-1.7	0.6	0.7	2.5	-0.7
Birth weight	1.1	2.4	5.9	2.4	-1.9	0.1	-1.3	0.8
Health satisfaction	1.1	1.5	3.4	-0.6	-0.7	0.9	-1.5	1.8
Mood swings	1.1	1.9	3.5	-1.8	-1.9	0.8	1.4	-0.5
Osteoarthritis (self-reported)	1.1	1.4	4.8	-2.2	-0.6	1.1	0.3	0.7
Number of operations (self-reported)	1.1	1.6	7.4	-0.2	-0.2	-2.7	0.6	0.6
Neuroticism (Nagel 2018)	1.0	2.4	6.8	-2.6	-0.5	0.9	1.5	-1.2
Verbal and Numeric Reasoning (VNR)	1.0	2.3	4.9	1.9	1.6	2.2	-0.8	-0.1
Blood White Count	1.0	7.7	18.7	3.0	-0.1	0.1	4.3	-3.3
Diabetes (father)	1.0	1.2	2.0	-0.9	0.5	1.0	1.4	-1.4
Age when periods started (menarche)	1.0	2.4	8.9	-0.3	-0.7	-1.4	-0.8	3.0
Illnesses of siblings	1.0	1.5	2.7	1.2	-1.3	0.5	-1.6	1.1
Neuroticism score	1.0	2.1	6.0	-1.4	-0.1	1.0	2.4	-1.1
Impedance of arm (right)	1.0	4.5	8.1	-2.8	-0.9	-1.5	-2.7	2.0
Impedance of arm (left)	1.0	4.6	8.0	-2.8	-0.6	-1.8	-2.7	2.0
Medication: Allopurinol	1.0	1.4	4.5	2.1	0.8	-0.9	0.9	0.2
Whole body fat mass	1.0	4.2	11.5	-1.3	0.9	2.3	1.3	-3.4
Pulse rate, automated reading	1.0	3.1	7.0	-1.1	0.6	1.0	2.7	-2.4
Supplements: Vitamin C	1.0	1.2	5.7	-2.4	-0.0	0.1	-0.3	0.2
Illnesses of father: Heart disease	1.0	1.3	4.2	2.1	-1.3	0.7	0.6	0.1
Mineral and other dietary supplements	1.0	1.3	3.6	-0.2	1.2	1.2	0.4	-1.9
Schizophrenia (2018)	0.9	1.9	6.7	2.6	1.7	0.1	0.0	0.0
Crohns Disease (2017)	0.9	2.0	3.8	1.9	1.0	1.9	0.3	-1.3
Coronary Artery Disease (CAD)	0.9	1.0	4.1	2.0	1.0	-0.0	0.0	0.0
Number of treatments/medications taken	0.9	1.6	5.3	-1.2	-0.4	-0.9	2.3	0.0
Stomach or abdominal pain in last month	0.9	1.1	3.1	-1.8	1.0	0.4	0.7	-1.0
Hearing difficulty/problems with background noise	0.9	1.4	5.2	2.3	0.9	1.0	-0.3	-0.2
Worrier / anxious feelings	0.9	1.7	6.6	-2.6	-1.0	0.1	0.9	-0.4
Number of full brothers	0.9	1.1	4.3	-0.4	-1.0	0.2	-0.4	2.1
Medication: Ibuprofen	0.9	1.1	3.5	-1.0	-0.4	-0.0	1.9	-1.0
Heart disease (mother)	0.9	1.1	2.6	1.3	0.9	0.4	1.6	-0.5
Suffer from ‘nerves’	0.9	1.4	3.4	-1.1	-1.0	1.2	1.9	-0.4
Smoking status: Previous	0.9	1.4	3.4	1.9	-1.3	0.0	-0.2	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	7.1	2.7	-0.1	0.4	-1.3	0.0
Friendships satisfaction	0.9	1.1	2.1	1.1	-1.2	0.7	-0.3	-1.4
Breast cancer (self-reported)	0.9	1.1	4.3	2.1	-0.1	1.1	-0.2	-0.0
Miserableness	0.9	1.6	3.8	-2.0	-1.0	0.0	1.8	-0.5
Medication: Blood pressure	0.9	1.7	5.8	-0.9	1.1	-0.6	2.4	-0.7
Irritability	0.9	1.5	5.8	-0.8	0.6	-0.1	2.4	-0.9
Ever had prostate specific antigen (PSA) test	0.9	1.1	3.3	1.8	-0.7	-1.0	0.7	0.0
Myopia	0.9	1.3	3.9	1.0	-0.7	-0.6	-2.0	0.8
Medication: Omeprazole (e.g. Zanprol)	0.9	1.2	5.1	-2.3	0.4	-0.4	0.2	0.6
Pack years of smoking	0.9	1.3	2.4	-1.1	1.5	1.4	-0.5	-0.9
Impedance of whole body	0.9	4.4	10.8	-3.3	-0.4	-2.3	-1.6	1.8
Vitamin and mineral supplements	0.8	1.1	4.2	2.0	0.6	0.3	0.4	-0.6
Average weekly fortified wine intake	0.8	1.0	2.9	-0.4	0.5	1.2	0.3	-1.7
Taking other prescription medications	0.8	1.3	2.2	-1.2	-1.5	-1.2	0.8	0.8
High blood pressure (mother)	0.8	1.1	4.6	-0.8	-0.3	-2.1	0.3	-0.2
Trunk fat mass	0.8	3.2	9.7	-1.1	0.2	2.1	0.8	-3.1
Falls in the last year	0.8	1.1	3.4	-0.0	0.6	-0.0	1.4	-1.9
Exposure to tobacco smoke at home	0.8	0.9	2.2	0.0	-1.5	-0.8	0.9	0.8
Tense / ‘highly strung’	0.8	1.4	3.5	-1.9	0.7	0.8	1.4	-0.3
Peak expiratory flow (PEF)	0.8	1.9	3.5	1.9	-0.8	-1.8	1.5	0.3
Had major operations	0.8	0.9	3.0	1.7	0.2	-1.1	-0.6	0.0
Age at last live birth	0.8	1.1	2.7	1.6	-0.2	-0.4	-0.8	-1.5
Ever depressed for a whole week	0.8	1.0	1.8	0.6	-1.1	-1.3	0.8	0.9
Depression (Nagel 2018)	0.7	1.1	3.1	-1.4	-1.8	0.2	0.4	0.4
Worry (Nagel 2018)	0.7	1.5	4.0	-2.0	0.4	0.9	1.0	-1.3
Bipolar Disorder (2011)	0.7	0.6	1.4	0.8	1.1	1.2	0.0	0.0
LDL Cholesterol	0.7	1.2	4.4	2.1	-0.4	-1.2	0.0	0.0
Type 2 Diabetes (T2D) (2018)	0.7	1.4	3.3	-1.8	0.6	-1.3	-0.4	1.1
Hand grip strength (left)	0.7	1.9	6.3	2.5	1.2	-0.4	1.3	-0.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.1	-0.1	-0.2	-0.9	-1.0	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.0	-0.7	-1.4	0.6	0.8	1.0
Had other major operations	0.7	0.9	2.6	0.9	0.2	-0.1	1.6	-0.9
Fluid intelligence score	0.7	1.4	5.3	2.3	-0.3	1.2	0.2	-0.3
Happiness	0.7	0.8	1.4	1.1	-1.2	-0.1	-1.1	-0.5
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.8	1.3	0.2	-0.2	1.0	1.1
Medication: Omeprazole	0.7	0.8	3.1	-1.8	-0.0	-0.4	0.3	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.5	0.3	1.2	-0.2	1.2	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.5	-1.6	-0.7	-0.9	-0.0	0.7
Osteoporosis (self-reported)	0.7	0.8	3.5	-1.9	0.2	-0.6	0.2	-0.3
Commuting to job workplace: Public transport	0.7	0.9	2.9	0.9	-0.0	-0.2	0.8	-1.7
Commuting to job workplace: Cycle	0.7	0.8	1.8	1.0	-1.3	-0.1	-0.9	0.6
Blood Eosinophil Count	0.6	4.3	13.5	-3.7	1.3	-0.8	2.4	-0.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.2	-0.0	-0.2	1.0	1.5	-0.8
Medication for hormone replacement therapy	0.6	0.7	1.2	-0.2	0.9	-0.3	1.1	-1.1
Supplements: Glucosamine	0.6	0.8	2.6	-1.6	0.1	0.3	1.1	0.1
Chronic bronchitis/emphysema (father)	0.6	0.7	1.4	0.6	-0.2	-1.2	0.6	1.1
Impedance of leg (left)	0.6	2.9	8.6	-2.9	0.8	-2.0	-0.2	1.1
Time employed in main current job	0.6	0.7	1.2	0.8	1.1	0.7	-1.1	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.5	0.4	-1.2	-0.5	-0.4	1.1
Birth weight of first child	0.6	1.2	2.7	1.6	-1.4	-0.0	0.8	0.8
Pulse wave reflection index	0.6	0.8	1.8	0.5	1.3	-0.7	-0.2	1.2
Headache pain in last month	0.6	1.1	4.1	-2.0	-0.4	0.2	-0.7	0.7
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.0	1.1	1.0	1.4	-0.5	-0.6
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.3	-1.0	0.9	0.6	-0.4	1.1
Exposure to tobacco smoke outside home	0.6	0.7	1.9	-1.4	-0.5	-0.8	0.9	0.3
Age at first live birth	0.6	1.1	2.6	1.4	-0.5	-0.7	-0.2	-1.6
Neck or shoulder pain in last month	0.6	0.8	3.4	-0.3	-0.3	0.3	1.8	0.5
Overall health rating	0.6	1.3	2.5	-1.2	0.2	1.6	1.5	-0.7
Medication: Aspirin	0.6	0.8	1.6	-1.0	-1.0	-0.4	1.3	-0.3
Hypertension (Self-reported)	0.6	1.7	4.6	-2.1	1.4	0.1	1.1	-0.9
Long-standing illness, disability or infirmity	0.6	0.9	1.8	-1.4	-0.8	0.4	1.2	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.8	0.2	1.4	-0.1	1.1	-0.4
Medication: Gliclazide	0.6	0.7	1.8	0.3	0.8	-0.9	-0.1	1.3
Average weekly champagne plus white wine intake	0.6	0.8	3.2	1.8	0.0	-0.7	0.4	-0.4
Mother’s age at death	0.6	0.8	1.9	1.2	-1.4	-0.6	0.5	-0.4
Medication: Atorvastatin	0.6	0.8	2.5	1.6	0.3	1.1	-0.1	0.0
Cholesterol lowering medication	0.6	0.9	2.3	0.7	-0.4	-1.5	1.1	0.7
Bipolar Disorder (2018)	0.5	0.8	2.6	1.2	1.6	-0.1	0.0	0.0
Sensitivity / hurt feelings	0.5	0.9	3.7	0.5	-0.4	-0.6	1.9	-0.3
Hearing difficulty/problems: Yes	0.5	0.8	2.4	0.1	1.1	-0.4	-0.6	1.5
Diabetes (mother)	0.5	0.6	2.1	-1.5	0.7	-0.2	0.5	-0.0
Impedance of leg (right)	0.5	2.6	6.3	-2.5	0.8	-1.7	-0.9	1.5
Qualifications: CSEs or equivalent	0.5	0.7	2.1	-0.8	-0.1	-0.9	-0.4	1.4
High blood pressure	0.5	1.4	3.8	-1.9	1.1	-0.1	1.2	-0.8
Waist circumference	0.5	2.0	4.1	-0.2	1.1	1.8	1.1	-2.0
Diabetes (self-reported)	0.5	0.8	2.5	-0.3	0.7	-1.6	0.5	0.8
Hair/balding pattern: Pattern 3	0.5	0.7	2.7	-0.4	-0.2	0.4	0.8	-1.6
Length of working week for main job	0.5	0.5	1.9	-1.4	-0.6	-0.2	0.5	-0.2
Loud music exposure frequency	0.5	0.5	1.4	-1.2	0.3	1.0	-0.1	0.1
Medication: Amlodipine	0.5	0.8	1.8	0.7	-1.4	-0.1	0.9	0.9
Worry too long after embarrassment	0.5	0.8	2.1	0.0	0.4	1.5	1.2	-0.7
Pulse wave peak to peak time	0.5	0.6	2.3	-1.5	-0.0	0.1	0.2	-0.8
Eye problems/disorders: None of the above	0.5	0.6	1.7	0.2	-1.3	0.7	0.6	-0.5
Medication: Blood pressure	0.5	0.9	1.6	-1.0	-1.0	-1.3	0.8	0.3
Leg pain on walking	0.5	0.7	1.3	-1.1	0.6	0.7	1.0	0.2
Diabetes diagnosed by doctor	0.5	0.9	3.1	-0.5	0.6	-1.8	0.6	0.6
Eye problems/disorders: Cataract	0.5	0.6	1.5	0.5	1.1	0.3	-1.2	0.3
Medication: Aspirin	0.5	0.7	1.5	-0.4	-1.2	-0.6	1.1	-0.2
Wears glasses or contact lenses	0.5	0.6	1.8	0.9	-1.3	-0.3	-0.5	-0.2
Alzheimer’s Disease (in father)	0.4	0.4	1.3	-1.2	-0.8	0.4	-0.0	-0.2
Alzheimer’s Disease (including proxy)	0.4	0.6	1.6	-1.3	-0.5	1.0	0.4	0.2
Age at First Birth	0.4	0.6	2.1	1.5	0.6	0.6	0.0	0.0
HbA1C	0.4	0.5	1.9	-0.2	0.6	1.4	0.0	0.0
HDL Cholesterol	0.4	0.7	1.8	-1.3	-0.8	1.2	0.0	0.0
Ulcerative Colitis	0.4	0.6	1.6	1.2	0.2	-1.3	0.0	0.0
Smoking Status	0.4	1.1	3.2	-0.6	1.8	0.9	-0.8	0.7
Hypothyroidism (self reported)	0.4	0.9	1.7	1.3	0.7	0.7	-1.3	0.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.9	-1.0	-1.0	-0.0	0.2	0.8
Hair/balding pattern: Pattern 2	0.4	0.5	0.8	-0.7	0.9	0.6	0.6	0.8
Mouth/teeth dental problems	0.4	0.7	1.9	-0.8	0.7	0.5	-0.3	-1.4
Number of live births	0.4	0.5	1.5	-0.2	0.4	-1.0	-1.2	-0.1
Medication: Cholesterol lowering	0.4	0.7	1.6	0.3	-0.3	-1.2	1.0	0.8
Hair/balding pattern: Pattern 4	0.4	1.0	2.0	1.0	-1.4	0.1	-0.8	1.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.1	1.5	0.5	0.8	-0.9	-0.1
Shortness of breath walking on level ground	0.4	0.5	1.1	0.3	0.2	-0.8	1.0	0.7
Chest pain or discomfort	0.4	0.5	2.1	0.4	1.4	-0.5	-0.3	0.2
Guilty feelings	0.4	0.6	1.9	0.4	0.3	-0.5	1.4	0.7
Ever taken oral contraceptive pill	0.4	0.5	2.1	1.4	0.1	0.1	-0.5	0.3
High cholesterol (Self-reported)	0.4	0.7	1.8	-0.7	-1.0	0.1	0.4	1.4
Medication: Bendroflumethiazide	0.4	0.6	1.4	-0.7	0.7	0.1	1.2	-0.7
Medication: Lisinopril	0.4	0.6	1.4	-1.2	0.4	0.8	0.7	0.2
Average weekly beer plus cider intake	0.4	0.6	2.3	-0.4	-0.4	0.3	-1.5	0.6
Unable to work because of sickness or disability	0.4	0.5	1.4	-1.2	0.1	0.5	-0.8	0.3
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.9	1.7	-1.1	0.1	-1.2	0.6
Mean Putamen Volume	0.3	0.4	1.4	0.5	1.2	-0.2	0.0	0.0
Triglycerides	0.3	0.4	1.7	1.3	0.5	-0.4	0.0	0.0
Blood Red Count	0.3	2.5	3.7	-1.5	1.8	0.9	1.6	-1.9
Cardiovascular Disease	0.3	1.1	2.5	-1.6	1.2	0.2	0.7	-1.0
Chronotype (morning person)	0.3	0.7	1.8	1.0	-0.4	-0.8	-0.2	-1.3
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.1	0.6	0.3	-0.1	1.1	-0.4
Townsend deprivation index at recruitment	0.3	0.5	1.1	-1.0	-0.1	0.2	-0.5	1.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	0.3	-0.5	0.4	-0.8	0.6
Number of incorrect matches in round	0.3	0.4	1.0	-0.4	-1.0	-0.6	-0.7	0.3
Pulse rate	0.3	0.6	1.5	-0.2	-0.6	0.3	0.9	-1.2
High blood pressure (siblings)	0.3	0.4	0.9	-0.6	0.7	-0.6	0.3	-1.0
Forced vital capacity (FVC), Best measure	0.3	1.0	2.6	0.8	1.6	0.9	0.1	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.2	-1.1	0.2	0.7	0.0	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.3	-0.1	0.6	0.0	0.5	-1.2
Migraine (self-reported)	0.3	0.4	1.1	-1.0	-0.0	0.6	0.5	0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.8	-0.9	0.6	0.6	0.2	0.6
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.7	-0.4	-0.2	-0.4	1.3	-0.1
Illnesses of father: None of the above (group 1)	0.3	0.4	1.1	0.1	-0.5	-0.6	-0.7	1.1
Hearing aid user	0.3	0.3	0.9	-0.2	-0.1	-0.9	0.9	-0.0
Alcohol drinker status: Previous	0.3	0.3	0.7	-0.4	-0.8	-0.6	0.6	-0.4
Alzheimer’s Disease (in mother)	0.2	0.3	1.0	0.1	0.4	1.0	0.4	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	1.0	0.4	0.7	1.0	0.0	0.0
Hair Pigment	0.2	5.6	19.3	-4.4	-0.4	2.8	-0.2	-0.8
Tanning	0.2	2.4	5.2	1.1	1.1	1.6	1.3	-2.3
Systolic blood pressure, automated reading	0.2	0.5	1.0	-1.0	0.3	-0.8	0.7	-0.2
Angina	0.2	0.2	0.5	0.7	0.7	0.2	-0.2	0.0
Multivitamins +/- minerals	0.2	0.3	0.9	-1.0	0.2	-0.5	0.0	0.5
Forced vital capacity (FVC)	0.2	0.9	1.7	0.9	1.3	0.3	0.9	-0.9
Heart attack	0.2	0.3	1.1	1.0	-0.3	-0.2	0.3	0.1
Medication: Ramipril	0.2	0.3	1.1	-0.0	-0.2	-1.0	0.3	-0.2
Mouth/teeth dental problems: Dentures	0.2	0.4	1.1	0.1	0.4	0.4	1.0	0.5
Angina (self-reported)	0.2	0.3	0.8	0.9	0.6	0.2	-0.2	0.1
Basal cell carcinoma (self-reported)	0.2	0.2	1.0	0.0	1.0	0.1	0.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.6	0.8	-0.4	-0.4	0.3	0.3
Fasting Glucose	0.1	0.1	0.3	0.2	0.3	0.5	0.0	0.0
Lupus	0.1	0.2	0.4	0.0	-0.3	-0.1	0.6	-0.6
Rheumatoid Arthritis	0.1	0.2	0.5	-0.2	0.7	-0.7	0.0	0.0
Systolic Blood Pressure	0.1	0.5	1.4	-1.2	0.7	-0.3	0.2	0.7
Medication: Atenolol	0.1	0.1	0.4	0.6	0.0	-0.0	-0.3	-0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.3	-0.3	0.5	-0.7	1.2	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.6	-0.3	0.7	-0.4	0.8	-0.4
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Nervous feelings	0.0	0.1	0.2	-0.3	-0.3	-0.0	0.5	0.1

Hub : Genes

RILPL1

Models

Trait associations