[Hub]/) : Traits : Systolic blood pressure, automated reading : ←

chr20:61,522,825-62,912,463

Best TWAS P=7.33e-13 · Best GWAS P=2.3e-10 conditioned to 0.17

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LIME1	0.04	0.00	bslmm	439	0.01	3.3e-02	-4.9	5.8	6.6e-09	-0.02	0.27	0.07	TRUE
2	CommonMind	Brain Pre-frontal Cortex	ZBTB46	0.11	0.08	lasso	3	0.07	1.2e-08	-5.8	-5.8	6.6e-09	0.26	0.04	0.96	TRUE
3	GTEx	Adipose Subcutaneous	TCEA2	0.11	0.06	lasso	2	0.03	9.4e-04	6.0	6.1	1.3e-09	-0.51	0.01	0.96	FALSE
4	GTEx	Adrenal Gland	OPRL1	0.48	0.29	enet	21	0.22	1.5e-08	-6.3	-5.5	3.5e-08	0.84	0.00	1.00	FALSE
5	GTEx	Adrenal Gland	RGS19	0.32	0.20	lasso	8	0.21	5.8e-08	-6.3	-6.6	3.4e-11	0.97	0.00	1.00	FALSE
6	GTEx	Artery Aorta	OPRL1	0.27	0.19	lasso	4	0.17	1.4e-09	-6.3	-6.8	9.7e-12	0.95	0.00	1.00	FALSE
7	GTEx	Artery Aorta	TCEA2	0.09	0.04	lasso	3	0.03	1.3e-02	-6.3	7.2	7.3e-13	-0.94	0.00	1.00	TRUE
8	GTEx	Artery Tibial	OPRL1	0.10	0.10	lasso	2	0.06	1.1e-05	-6.3	-6.4	1.8e-10	1.00	0.00	1.00	FALSE
9	GTEx	Artery Tibial	RGS19	0.12	0.07	lasso	2	0.07	2.8e-06	5.6	-5.6	2.0e-08	0.82	0.01	0.99	FALSE
10	GTEx	Brain Cerebellar Hemisphere	OPRL1	0.27	0.14	lasso	7	0.17	4.4e-05	-6.3	-5.4	5.4e-08	0.95	0.00	0.96	FALSE
11	GTEx	Brain Cerebellum	RGS19	0.28	0.22	lasso	4	0.18	7.2e-06	-6.3	-5.7	1.1e-08	0.98	0.00	0.99	FALSE
12	GTEx	Breast Mammary Tissue	GMEB2	0.18	0.02	lasso	5	0.06	3.0e-04	-4.9	-6.2	4.3e-10	0.20	0.14	0.17	FALSE
13	GTEx	Breast Mammary Tissue (Female)	GMEB2	0.36	0.06	lasso	4	0.05	1.2e-02	-5.1	-5.6	2.2e-08	0.02	0.14	0.16	FALSE
14	GTEx	Cells Transformed fibroblasts	RGS19	0.37	0.28	lasso	8	0.29	3.2e-22	5.6	-5.7	9.5e-09	0.89	0.02	0.98	FALSE
15	GTEx	Esophagus Mucosa	RGS19	0.43	0.28	enet	17	0.34	7.9e-24	-6.3	-6.0	1.6e-09	0.93	0.00	1.00	FALSE
16	GTEx	Esophagus Muscularis	OPRL1	0.17	0.14	lasso	1	0.13	4.7e-08	-6.3	-6.3	2.3e-10	1.00	0.00	1.00	FALSE
17	GTEx	Esophagus Muscularis	RGS19	0.22	0.10	lasso	4	0.10	1.6e-06	-6.3	-6.1	1.2e-09	0.96	0.00	1.00	FALSE
18	GTEx	Muscle Skeletal	RGS19	0.26	0.16	lasso	4	0.16	5.1e-15	5.6	-5.2	2.0e-07	0.83	0.08	0.92	FALSE
19	GTEx	Nerve Tibial	OPRL1	0.20	0.15	lasso	3	0.14	3.3e-10	-6.3	-6.5	7.5e-11	0.98	0.00	1.00	FALSE
20	GTEx	Pancreas	OPRL1	0.39	0.27	lasso	5	0.32	6.9e-14	-6.3	-6.0	2.5e-09	0.94	0.00	1.00	FALSE
21	GTEx	Skin Sun Exposed Lower leg	OPRL1	0.14	0.10	lasso	6	0.11	4.4e-09	5.6	-6.0	2.0e-09	0.90	0.00	1.00	FALSE
22	GTEx	Skin Sun Exposed Lower leg	RGS19	0.42	0.26	lasso	6	0.33	4.6e-28	-6.3	-6.3	2.9e-10	0.94	0.00	1.00	FALSE
23	GTEx	Stomach	OPRL1	0.36	0.23	enet	16	0.19	1.3e-09	-6.3	-6.6	4.0e-11	0.89	0.00	1.00	FALSE
24	GTEx	Stomach	RGS19	0.18	0.25	lasso	2	0.25	2.2e-12	-6.3	-6.3	2.4e-10	1.00	0.00	1.00	FALSE
25	GTEx	Thyroid	RGS19	0.23	0.14	enet	11	0.19	3.3e-14	5.6	-5.8	5.1e-09	0.89	0.01	0.99	FALSE
26	GTEx	Vagina	RGS19	0.39	0.08	lasso	8	0.03	7.5e-02	5.6	-6.3	4.1e-10	0.89	0.01	0.91	FALSE
27	GTEx	Whole Blood	OPRL1	0.09	0.06	enet	8	0.07	4.3e-07	5.5	5.5	3.2e-08	-0.90	0.01	0.99	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	ZBTB46	0.11	0.07	lasso	1	0.06	5.2e-08	-5.8	-5.8	7.9e-09	0.25	0.04	0.96	FALSE
29	YFS	Blood	OPRL1	0.07	0.07	lasso	5	0.09	5.0e-27	-6.3	5.6	2.3e-08	-0.91	0.00	1.00	FALSE
30	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C20orf201	0.05	0.00	enet	12	0.01	6.8e-02	2.7	5.1	2.7e-07	-0.57	0.01	0.10	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	RGS19	0.03	0.02	blup	48	0.02	6.9e-06	5.5	-5.6	1.7e-08	0.73	0.02	0.97	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC2A4RG	0.03	0.01	blup	48	0.02	2.4e-03	-5.0	5.6	1.9e-08	-0.02	0.01	0.84	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	LIME1	0.02	0.03	blup	47	0.02	6.2e-03	-4.8	-5.3	1.2e-07	-0.03	0.01	0.79	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	OPRL1	0.03	0.02	lasso	1	0.01	3.5e-02	-6.3	-6.3	2.3e-10	1.00	0.00	0.98	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RGS19	0.05	0.02	blup	48	0.02	1.1e-03	3.5	-5.6	1.9e-08	0.85	0.01	0.98	FALSE
36	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RGS19	0.11	0.00	blup	48	0.03	1.7e-02	5.5	-6.8	1.2e-11	0.69	0.02	0.62	TRUE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	RGS19	0.07	0.05	blup	48	0.07	1.1e-07	-4.1	-6.6	4.1e-11	0.88	0.09	0.91	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	RGS19	0.07	0.04	blup	48	0.06	8.4e-07	4.1	-5.4	7.7e-08	0.84	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	ZGPAT	0.05	0.04	blup	60	0.03	2.3e-04	-4.9	5.6	2.2e-08	0.04	0.03	0.96	FALSE