TWAS hub - ZBTB46

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.114	0.0370	0.00044	0.075	0.033	0.047	0.053	0.068	1.8e-09	5.9e-05	2.0e-06	4.2e-07	1.1e-08
2	GTEx	Esophagus Mucosa	0.135	0.0520	0.00570	0.038	NA	0.011	NA	0.026	1.4e-03	NA	5.6e-02	NA	6.6e-03
3	ROSMAP	Brain Pre-frontal Cortex	0.114	0.0393	0.00220	0.068	0.031	0.022	0.054	0.058	4.4e-09	5.9e-05	6.2e-04	1.5e-07	5.2e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Diabetes diagnosed by doctor	13.4	22.0	30.7	-5.5	-2.3	-5.5
Vascular/heart problems diagnosed by doctor	12.8	35.0	51.0	7.1	2.2	7.0
High blood pressure	11.9	33.2	49.0	-7.0	-1.6	-6.9
Hypertension (Self-reported)	11.9	33.0	49.3	-7.0	-1.4	-6.9
Cardiovascular Disease	11.5	38.0	57.1	-7.6	-1.0	-7.5
Medication: Blood pressure	11.4	21.7	33.1	-5.8	-0.8	-5.6
Medication for cholesterol	11.1	16.8	24.6	5.0	1.2	4.9
Angina	9.5	12.5	16.2	-4.0	-2.5	-3.9
Diabetes (self-reported)	9.4	14.4	19.1	-4.4	-2.3	-4.4
Type 2 Diabetes (T2D) (2018)	9.3	17.5	24.2	-4.9	-2.2	-4.9
Systolic blood pressure, automated reading	8.5	24.5	33.7	-5.8	-2.6	-5.8
Systolic Blood Pressure	8.3	41.5	59.6	-7.7	-2.4	-7.7
Medication for cholesterol, blood pressure or diabetes	8.3	13.7	19.4	4.4	1.8	4.3
Angina (self-reported)	8.3	10.9	13.8	-3.7	-2.5	-3.6
Medication: Metformin	7.6	10.7	15.1	-3.9	-1.5	-3.9
Long-standing illness, disability or infirmity	7.5	11.5	13.0	-3.6	-3.1	-3.4
Medication: Blood pressure	7.3	12.8	18.6	-4.3	-1.2	-4.3
Illnesses of siblings	6.4	9.0	9.4	3.0	2.9	3.1
Illnesses of father: None of the above (group 1)	6.1	7.6	10.3	3.1	1.7	3.2
Chest pain or discomfort	5.9	8.5	12.5	-3.5	-1.3	-3.4
Medication: Gliclazide	5.9	6.7	9.3	-3.1	-1.4	-2.9
Medication: Aspirin	5.5	7.2	9.4	-3.1	-1.8	-3.0
Medication: Ramipril	5.4	6.9	9.9	-3.1	-1.0	-3.2
Medication: Simvastatin	5.4	8.0	11.7	-3.4	-1.0	-3.4
Medication: Levothyroxine sodium	5.2	8.8	14.2	-2.4	-3.8	-2.5
Number of self-reported non-cancer illnesses	5.2	9.1	13.5	-3.7	-0.9	-3.6
Hypothyroidism (self reported)	5.1	11.8	12.2	-3.5	-3.3	-3.5
Ever unenthusiastic/disinterested for a whole week	5.0	6.2	9.6	-3.1	-0.7	-2.9
Medication: Cholesterol lowering	5.0	7.8	10.6	-3.3	-1.7	-3.1
High blood pressure (siblings)	4.6	6.6	6.9	-2.6	-2.6	-2.5
Hypothyroidism/myxoedema (self-reported)	4.3	8.5	10.7	-2.7	-3.3	-2.7
Exposure to tobacco smoke outside home	4.3	5.7	7.7	-2.8	-1.5	-2.7
Medication: Aspirin	4.3	5.6	7.0	-2.6	-1.7	-2.6
Number of treatments/medications taken	4.2	7.6	11.1	-3.3	-1.2	-3.2
Serious illness, injury or assault to yourself	4.2	5.1	7.3	-2.7	-0.8	-2.7
Medication: Atenolol	4.2	5.2	7.6	-2.7	-0.9	-2.8
Cholesterol lowering medication	4.1	6.1	8.4	-2.9	-1.3	-2.8
High cholesterol (Self-reported)	4.0	7.0	9.2	-3.0	-1.7	-3.0
Medication: Lisinopril	4.0	5.2	7.6	-2.8	-0.5	-2.8
Medication: Bendroflumethiazide	3.9	5.9	9.0	-3.0	-0.3	-2.9
Prospective memory result	3.8	4.6	6.5	2.6	1.0	2.5
Number of operations (self-reported)	3.7	5.6	8.7	-2.9	0.8	-2.7
Gout (self-reported)	3.6	5.0	6.4	-2.1	-2.5	-2.0
Illnesses of father: Heart disease	3.6	5.0	5.9	-2.4	-1.9	-2.4
Lung FVC	3.3	16.6	25.6	5.1	-0.9	4.8
Medication: Allopurinol	3.3	4.5	6.1	-2.0	-2.5	-1.9
Taking other prescription medications	3.2	5.0	5.4	-2.3	-2.1	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	3.1	4.7	7.1	-2.7	-0.5	-2.6
Illnesses of father: High blood pressure	3.1	3.8	5.9	-2.4	0.0	-2.4
Bilateral oophorectomy (both ovaries removed)	3.0	3.5	4.8	-2.1	-1.1	-2.2
Heart attack	2.9	3.7	5.9	-2.4	-0.4	-2.3
Chronic bronchitis/emphysema (mother)	2.8	3.3	3.7	-1.9	-1.7	-1.8
Asthma	2.6	5.0	8.3	-2.9	-0.5	-2.6
Medication: Lansoprazole	2.5	2.9	3.6	-1.6	-1.9	-1.6
Loud music exposure frequency	2.5	2.7	7.3	-0.6	2.7	-0.7
Number of children fathered	2.5	2.8	4.1	-2.0	-0.7	-2.0
Overall health rating	2.5	5.4	6.2	-2.5	-2.3	-2.2
Leg pain on walking	2.5	3.1	4.2	-2.1	1.1	-1.9
Average weekly champagne plus white wine intake	2.5	3.4	3.8	1.8	1.9	1.7
Ever depressed for a whole week	2.5	3.1	4.5	-2.1	-0.7	-2.1
Heart attack/myocardial infarction (self-reported)	2.5	3.2	5.1	-2.3	-0.3	-2.1
Medication: Co-codamol	2.4	2.8	5.3	-1.3	-2.3	-1.2
Medication for pain relief, constipation, heartburn	2.4	4.1	5.8	2.4	1.3	2.1
Heart disease (mother)	2.4	2.9	3.3	-1.6	-1.8	-1.7
Medication: Amlodipine	2.3	3.2	3.6	-1.9	-1.5	-1.9
Emphysema/chronic bronchitis	2.3	2.5	3.4	1.7	1.2	1.8
Ulcerative Colitis (UC)	2.2	4.1	5.2	2.3	1.5	2.2
Alcohol intake versus 10 years previously	2.2	3.3	4.1	1.6	2.0	1.8
Falls in the last year	2.2	3.0	4.6	-2.1	-0.4	-2.2
Depression (self-reported)	2.2	2.6	6.1	-1.0	-2.5	-0.9
Birth weight	2.2	4.9	7.2	2.7	-0.5	2.7
Asthma (self-reported)	2.2	4.4	7.0	-2.6	-0.9	-2.3
Alcohol drinker status: Never	2.2	2.6	4.0	2.0	0.4	1.9
Fed-up feelings	2.1	3.8	5.7	-2.4	-0.4	-2.4
Length of working week for main job	2.1	2.3	6.9	-0.0	2.6	-0.0
Medication: Atorvastatin	2.1	2.5	3.2	-1.8	-1.3	-1.7
Age at First Birth	2.0	2.9	4.2	2.0	1.1	1.8
Fasting Glucose	2.0	2.4	2.9	-1.7	-1.2	-1.7
Forced expiratory volume in 1-second (FEV1)	2.0	6.8	10.7	3.3	0.5	3.1
Birth weight of first child	2.0	3.6	5.3	2.3	0.6	2.3
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	3.5	1.3	1.9	1.2
Forced vital capacity (FVC)	1.9	7.4	11.1	3.3	-1.0	3.2
Average weekly red wine intake	1.9	2.8	7.7	-0.6	-2.8	-0.6
Neuroticism (2016)	1.8	2.6	5.3	-1.2	-2.3	-1.1
Diabetes (mother)	1.8	2.3	5.6	-0.8	-2.4	-0.8
High blood pressure (mother)	1.8	2.6	3.7	-1.8	-0.9	-1.9
Number of live births	1.8	2.6	4.1	-1.8	-0.6	-2.0
Number of full sisters	1.8	2.1	6.4	-0.1	-2.5	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.8	5.2	2.3	1.5	2.0
Diastolic blood pressure, automated reading	1.8	5.6	8.0	-2.8	-0.9	-2.8
Depressed Affect (Nagel 2018)	1.7	3.5	5.2	-2.3	-0.9	-2.1
Qualifications: CSEs or equivalent	1.7	2.2	2.5	-1.6	1.3	-1.6
Fluid intelligence score	1.7	3.6	4.7	-2.0	-1.5	-2.2
LDL Cholesterol	1.6	2.5	3.8	-1.9	-0.6	-1.9
Rheumatoid Arthritis	1.6	2.2	5.2	0.8	2.3	0.9
Blood White Count	1.6	12.1	13.9	-3.7	3.4	-3.3
Waist circumference	1.6	5.7	8.0	-2.8	-1.5	-2.7
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	5.7	-2.4	-0.6	-2.2
Illnesses of mother	1.6	2.0	2.4	1.3	1.4	1.5
Medication: Ibuprofen	1.6	2.0	2.6	1.6	-0.9	1.6
Pulse rate, automated reading	1.6	5.0	8.2	2.6	-0.1	2.9
Breast cancer (self-reported)	1.6	1.9	2.5	-1.2	-1.6	-1.3
Verbal and Numeric Reasoning (VNR)	1.5	3.6	4.8	-1.9	-1.5	-2.2
HbA1C	1.5	1.6	1.7	-1.3	-1.3	-1.2
Age when periods started (menarche)	1.5	3.6	4.8	2.2	1.1	2.2
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.0	1.7	-0.3	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.8	7.5	2.7	0.8	2.5
Age at last live birth	1.5	2.2	6.4	0.2	2.5	0.1
Smoking status: Previous	1.5	2.3	3.4	-1.8	-0.7	-1.7
Triglycerides	1.4	2.3	2.5	-1.6	-1.4	-1.6
Supplements: Glucosamine	1.4	1.9	2.1	1.4	1.2	1.4
Forced vital capacity (FVC), Best measure	1.4	5.2	8.1	2.9	-0.2	2.7
Family relationship satisfaction	1.4	1.7	2.7	-1.6	0.6	-1.4
Average weekly beer plus cider intake	1.4	2.0	3.6	1.1	1.9	1.0
Respiratory disease	1.3	2.9	4.8	-2.2	-0.5	-1.9
Lung FEV1/FVC ratio	1.3	6.4	7.6	2.5	2.8	2.3
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	1.9	-1.4	0.9	-1.3
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	3.4	-1.7	0.1	-1.8
Number of full brothers	1.3	1.6	2.0	-1.2	-1.4	-1.2
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	1.7	1.3	-1.2	1.3
Illnesses of siblings: Diabetes	1.3	1.6	1.8	-1.4	-1.1	-1.4
Mother’s age at death	1.3	1.6	1.9	1.3	1.4	1.2
Blood Red Count	1.2	11.6	15.5	-3.9	-2.0	-3.9
Current tobacco smoking	1.2	2.0	2.6	1.4	-1.2	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	2.8	-1.7	-0.9	-1.5
Breastfed as a baby	1.2	1.4	2.2	1.4	0.1	1.5
Blood clot in the leg (DVT)	1.2	1.6	2.0	-1.4	-0.8	-1.4
Wheeze or whistling in the chest in last year	1.2	2.2	3.6	-1.9	0.3	-1.6
Medication: Paracetamol	1.2	1.8	2.2	-1.5	-1.3	-1.3
Age started oral contraceptive pill	1.2	1.5	3.4	0.7	1.8	0.7
Relative age voice broke	1.1	1.7	5.0	-0.1	-2.2	-0.1
Number of incorrect matches in round	1.1	1.8	2.8	1.6	0.3	1.7
Father’s age at death	1.1	1.5	2.5	1.6	0.2	1.4
Impedance of arm (left)	1.1	5.0	7.2	2.7	-1.1	2.6
Leg fat percentage (right)	1.1	4.2	5.2	-2.0	-2.3	-1.8
Loneliness, isolation	1.1	1.5	2.4	-1.6	0.0	-1.4
Neuroticism (Nagel 2018)	1.0	2.3	3.4	-1.8	-0.5	-1.8
BMI	1.0	5.8	8.6	-2.9	-0.6	-2.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.4	-0.3	1.9	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.5	-0.7	-1.6	-0.8
Smoking status: Current	1.0	1.5	2.2	1.3	-0.9	1.5
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	1.8	-1.3	-0.5	-1.3
Impedance of whole body	1.0	5.1	7.7	2.8	-0.6	2.7
HDL Cholesterol	0.9	1.6	2.3	1.1	1.5	1.1
Waist Hip Ratio (WHR)	0.9	4.2	5.7	-2.4	-1.4	-2.2
Sensitivity / hurt feelings	0.9	1.6	1.6	-1.3	-1.2	-1.3
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	1.6	-1.3	-0.7	-1.2
Body mass index (BMI)	0.9	3.9	5.0	-2.2	-1.4	-2.1
Alcohol usually taken with meals	0.9	1.4	1.7	1.3	1.0	1.2
Impedance of arm (right)	0.9	4.0	6.0	2.4	-0.6	2.4
Pulse rate	0.9	1.5	2.0	1.3	-0.9	1.4
Glaucoma (self-reported)	0.9	1.1	1.7	1.2	-0.3	1.3
Age at first live birth	0.9	1.6	2.8	1.0	1.7	0.9
Leg fat mass (right)	0.9	3.4	3.8	-2.0	-1.7	-1.8
Mood swings	0.9	1.6	1.9	-1.3	-1.4	-1.1
Wears glasses or contact lenses	0.9	1.0	1.5	-1.0	-0.7	-1.2
Hearing aid user	0.9	1.1	1.3	-1.0	-1.2	-0.9
Fractured/broken bones in last 5 years	0.9	1.1	1.9	-1.4	-0.2	-1.2
Myopia	0.9	1.3	2.0	1.4	-0.7	1.2
Alcohol drinker status: Previous	0.9	1.0	1.4	-1.2	-0.4	-1.2
Ovarian Cancer	0.8	1.1	1.6	0.9	-1.3	0.9
Hearing difficulty/problems: Yes	0.8	1.3	3.1	0.6	1.8	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	2.8	-1.7	-0.7	-1.5
Hayfever, allergic rhinitis or eczema	0.8	1.7	2.2	1.5	0.8	1.4
Chronic bronchitis/emphysema (father)	0.8	0.9	1.5	-0.7	-1.2	-0.8
Past tobacco smoking	0.8	1.5	2.2	1.5	0.7	1.3
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.3	1.1	1.0	1.1
Time employed in main current job	0.8	0.9	2.6	-0.4	1.6	-0.3
Arm fat percentage (left)	0.8	3.2	6.0	-1.4	-2.5	-1.3
Eye problems/disorders: Cataract	0.8	1.0	1.1	-1.1	-0.9	-1.0
Ever taken oral contraceptive pill	0.8	0.8	1.0	1.0	-0.9	0.9
Commuting to job workplace: Public transport	0.8	1.0	1.5	-1.2	-0.2	-1.2
Schizophrenia (2018)	0.7	1.4	4.1	-0.0	-2.0	-0.1
Irritable Bowel Disease (IBD)	0.7	1.7	2.2	1.5	1.1	1.3
Heel T-Score	0.7	5.2	7.7	-2.8	-0.7	-2.7
Maternal smoking around birth	0.7	0.9	1.6	-1.1	0.1	-1.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.4	-0.6	1.2	-0.5
Impedance of leg (left)	0.7	3.2	4.9	2.2	-0.3	2.2
Arm fat percentage (right)	0.7	2.7	5.0	-1.3	-2.2	-1.2
Happiness	0.7	0.8	1.4	-0.8	1.2	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.6	-0.7	1.3	-0.7
Tense / ‘highly strung’	0.7	1.2	2.5	0.7	1.6	0.8
Peak expiratory flow (PEF)	0.7	1.5	2.0	1.4	0.9	1.3
Medication: Paracetamol	0.7	1.2	1.6	-1.3	-1.1	-1.0
Health satisfaction	0.7	0.9	1.7	-0.8	-1.3	-0.6
Shortness of breath walking on level ground	0.7	0.8	2.1	-0.5	1.5	-0.3
Osteoarthritis (self-reported)	0.7	0.9	1.3	1.0	-0.6	1.1
Arm fat mass (left)	0.7	3.0	3.1	-1.8	-1.7	-1.7
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.4	-1.2	-0.2	-1.1
Leg fat percentage (left)	0.7	2.6	3.1	-1.7	-1.5	-1.6
Leg fat mass (left)	0.7	2.8	3.6	-1.9	-1.4	-1.8
Prostate Cancer	0.6	0.9	1.4	1.1	0.5	1.2
Vitamin and mineral supplements	0.6	0.8	2.3	-0.1	-1.5	-0.0
Severe depression (siblings)	0.6	0.7	0.7	-0.9	0.8	-0.8
Multivitamins +/- minerals	0.6	0.8	1.3	-0.8	1.1	-0.7
Hearing difficulty/problems with background noise	0.6	0.9	1.4	1.2	0.2	1.2
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.3	-1.4	-0.0	-1.5
Body fat percentage	0.6	2.4	4.6	-1.2	-2.1	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.3	-1.1	-0.0	-1.0
Arm predicted mass (right)	0.6	3.1	4.9	-2.2	0.3	-2.0
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.4	0.6	-1.2	0.6
Heart disease (siblings)	0.6	0.7	1.2	-1.0	-0.3	-1.1
Schizophrenia (2014)	0.5	1.1	3.3	-0.1	-1.8	-0.2
Blood Platelet Count	0.5	6.3	9.5	-3.1	0.0	-3.0
Neuroticism	0.5	1.3	1.7	-1.3	-0.8	-1.2
Diabetes (father)	0.5	0.6	0.8	-0.9	0.2	-0.9
Impedance of leg (right)	0.5	2.6	3.2	1.8	-1.2	1.8
Trunk fat percentage	0.5	2.1	4.8	-0.9	-2.2	-0.8
Stomach or abdominal pain in last month	0.5	0.6	1.0	0.9	0.2	1.0
Trunk fat mass	0.5	2.3	3.4	-1.4	-1.9	-1.3
Hair/balding pattern: Pattern 2	0.5	0.6	1.5	0.3	-1.2	0.5
Hip circumference	0.5	2.2	2.4	-1.6	-1.5	-1.4
Lung cancer (father)	0.5	0.6	0.9	0.9	-0.1	1.0
Arm fat mass (right)	0.5	2.2	2.9	-1.4	-1.7	-1.3
Arm fat-free mass (right)	0.5	2.7	4.3	-2.1	0.0	-1.9
Qualifications: College or University degree	0.5	1.6	2.7	1.6	0.3	1.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.0	-1.0	0.0	-1.0
Medication: Omeprazole	0.5	0.6	1.2	-0.6	1.1	-0.4
Whole body fat mass	0.5	2.2	2.3	-1.5	-1.5	-1.4
Commuting to job workplace: Car/motor vehicle	0.5	0.6	0.9	0.6	0.9	0.7
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.0	-0.7	1.0	-0.8
Schizophrenia vs Biploar Disorder	0.4	0.5	1.6	-0.0	-1.3	0.0
Alzheimer’s Disease (in mother)	0.4	0.5	0.7	0.7	0.8	0.6
Alzheimer’s Disease (in father)	0.4	0.4	0.6	-0.8	0.3	-0.7
Body Mass Index (BMI) (2010)	0.4	0.6	1.3	0.5	-1.1	0.4
Lupus	0.4	0.7	0.8	-0.9	-0.7	-0.9
Relative age of first facial hair	0.4	0.8	2.1	0.4	-1.4	0.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.5	0.7	0.7	0.7
Supplements: Zinc	0.4	0.4	0.7	-0.5	-0.9	-0.5
Leg fat-free mass (left)	0.4	2.2	3.4	-1.9	-0.3	-1.7
Leg predicted mass (left)	0.4	2.2	3.5	-1.9	-0.2	-1.8
Had other major operations	0.4	0.5	1.5	-0.1	1.2	-0.0
Neuroticism score	0.4	0.8	1.0	-1.0	-0.8	-0.9
Weight	0.4	2.1	3.1	-1.8	-0.8	-1.6
Trunk fat-free mass	0.4	2.2	3.4	-1.9	0.4	-1.7
Worrier / anxious feelings	0.4	0.7	1.0	-0.7	-1.0	-0.8
Trunk predicted mass	0.4	2.2	3.4	-1.9	0.4	-1.7
Pulse wave reflection index	0.4	0.4	1.0	-0.4	1.0	-0.5
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.7	-0.8	0.4	-0.8
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.1	0.7	1.0	0.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.9	-0.9	0.4	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.7	0.9	0.4	0.7
Neck or shoulder pain in last month	0.4	0.6	0.9	-1.0	-0.0	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.7	-0.8	-0.0	-0.8
Whole body fat-free mass	0.4	2.2	3.4	-1.9	0.3	-1.7
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.2	0.2	1.1	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.8	-0.9	-0.3	-0.8
Whole body water mass	0.4	2.2	3.5	-1.9	0.3	-1.7
Eye problems/disorders: Glaucoma	0.4	0.4	1.1	0.3	-1.1	0.3
Basal metabolic rate	0.4	2.4	3.8	-2.0	-0.1	-1.8
Arm fat-free mass (left)	0.4	2.2	3.5	-1.9	0.5	-1.7
Arm predicted mass (left)	0.4	2.2	3.5	-1.9	0.6	-1.7
Bipolar Disorder or Schizophrenia	0.3	0.8	2.5	0.0	-1.6	-0.1
Smoking Status	0.3	0.7	1.6	-0.5	-1.3	-0.4
Hair Pigment	0.3	8.6	11.4	3.4	1.9	3.3
Hand grip strength (left)	0.3	0.7	1.1	-1.0	-0.4	-1.0
Average weekly spirits intake	0.3	0.4	0.6	-0.8	0.2	-0.8
Hand grip strength (right)	0.3	0.9	1.2	-1.1	-0.8	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.3	-0.1	-1.1	0.0
Sitting height	0.3	2.1	3.5	1.7	0.3	1.9
Nervous feelings	0.3	0.6	1.2	-0.6	-1.1	-0.5
Financial difficulties in last 2 years	0.3	0.4	0.7	-0.7	-0.2	-0.8
Noisy workplace	0.3	0.4	1.0	-0.3	1.0	-0.4
Headache pain in last month	0.3	0.6	0.7	-0.8	0.6	-0.8
Pulse wave peak to peak time	0.3	0.3	0.8	-0.4	0.9	-0.3
Eye problems/disorders: None of the above	0.3	0.4	0.5	0.7	0.5	0.6
Leg fat-free mass (right)	0.3	1.6	2.3	-1.5	0.5	-1.4
Friendships satisfaction	0.3	0.4	0.5	-0.7	0.5	-0.6
Qualifications: nursing, teaching	0.3	0.5	1.4	0.1	1.2	0.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.4	0.7	-0.7	0.7
Osteoporosis (self-reported)	0.3	0.3	0.4	0.6	0.5	0.6
Leg predicted mass (right)	0.3	1.8	2.8	-1.7	0.5	-1.6
Guilty feelings	0.3	0.5	0.7	-0.8	0.3	-0.9
Ever smoked	0.3	0.5	0.7	-0.8	-0.4	-0.8
Irritability	0.3	0.5	1.2	-0.4	-1.1	-0.2
Pain experienced in last month	0.3	0.6	1.2	0.6	-1.1	0.5
Basal cell carcinoma (self-reported)	0.3	0.3	0.9	0.3	-0.9	0.1
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.3	-0.2	-1.1	-0.4
Crohns Disease (2017)	0.2	0.4	0.5	0.7	0.7	0.5
Breast Cancer	0.2	0.4	0.5	0.6	-0.7	0.6
Crohns Disease (2012)	0.2	0.3	0.3	0.6	0.5	0.5
Primary Biliary Cirrhosis	0.2	0.2	0.7	0.1	0.8	0.0
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.4	-0.6	-0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	-0.6	-0.2	-0.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	0.1	-0.7	0.1
Migraine (self-reported)	0.2	0.3	0.3	-0.5	0.6	-0.4
Alcohol intake frequency.	0.2	0.5	0.6	0.7	0.7	0.8
Suffer from ‘nerves’	0.2	0.3	0.5	0.4	0.7	0.4
Mineral and other dietary supplements	0.2	0.3	0.7	0.2	-0.8	0.4
Risk taking	0.2	0.3	0.6	-0.5	0.8	-0.5
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.4	0.6	-0.2	0.6
Unable to work because of sickness or disability	0.2	0.3	0.4	-0.6	-0.6	-0.3
Commuting to job workplace: Cycle	0.2	0.3	0.4	-0.6	-0.1	-0.7
Supplements: Calcium	0.2	0.2	0.5	-0.3	0.7	-0.3
Depression (Nagel 2018)	0.1	0.2	0.3	-0.6	-0.2	-0.5
Worry (Nagel 2018)	0.1	0.2	0.4	-0.3	-0.6	-0.3
Reaction Time	0.1	0.1	0.2	-0.5	0.3	-0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	0.0	-0.6	0.0
Blood Eosinophil Count	0.1	1.0	1.3	-1.1	0.9	-1.0
Height	0.1	2.0	2.4	1.3	-1.6	1.3
Allergy or Eczema	0.1	0.3	1.0	0.1	1.0	0.0
Chronotype (morning person)	0.1	0.2	0.3	-0.5	0.0	-0.5
Medication for hormone replacement therapy	0.1	0.1	0.4	-0.0	-0.6	-0.0
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.3	0.5	-0.3
Average weekly fortified wine intake	0.1	0.1	0.2	-0.2	0.1	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	0.4	-0.0	0.4
Had menopause	0.1	0.1	0.1	-0.3	0.0	-0.3
Qualifications: None of the above	0.1	0.1	0.3	-0.6	-0.0	-0.3
Mouth/teeth dental problems	0.1	0.2	0.5	0.3	0.7	0.3
Pain all over the body in last month	0.1	0.1	0.1	-0.4	-0.3	-0.3
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	-0.1	-0.8	-0.1
Standing height	0.1	1.1	1.8	0.8	1.3	0.9
Hair/balding pattern: Pattern 4	0.1	0.3	0.3	0.6	-0.6	0.6
Comparative body size at age 10	0.1	0.3	0.4	0.6	0.6	0.5
Worry too long after embarrassment	0.1	0.1	0.1	-0.3	-0.3	-0.4
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.4	0.3	-0.3
Mean time to correctly identify matches	0.1	0.1	0.4	-0.1	0.6	-0.1
Had major operations	0.1	0.1	0.1	-0.3	-0.3	-0.2
Supplements: Vitamin C	0.1	0.2	0.5	0.2	0.7	0.0
Ever had bowel cancer screening	0.1	0.1	0.1	-0.1	-0.4	-0.3
Commuting to job workplace: Walk	0.1	0.2	0.2	-0.4	-0.4	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	-0.4	-0.3	-0.3
Miserableness	0.1	0.1	0.2	-0.4	-0.3	-0.3
Financial situation satisfaction	0.1	0.1	0.4	-0.2	0.6	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.1	-0.4	0.4	-0.2
Pack years of smoking	0.1	0.1	0.2	0.1	-0.4	0.3
Bipolar Disorder (2018)	0.0	0.0	0.0	0.1	-0.0	-0.1
Alzheimer’s Disease (including proxy)	0.0	0.1	0.2	0.1	0.4	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.0	0.0	0.1	-0.1	-0.3	-0.0
Ulcerative Colitis	0.0	0.0	0.0	-0.2	-0.1	-0.2
Tanning	0.0	0.2	0.3	-0.4	0.5	-0.3
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	0.3	0.2	0.3
Pack years adult smoking proportion	0.0	0.0	0.1	-0.3	-0.1	-0.0
Allergy	0.0	0.1	0.2	0.1	-0.5	-0.1
Exposure to tobacco smoke at home	0.0	0.0	0.0	0.0	-0.0	-0.0
Comparative height size at age 10	0.0	0.1	0.3	-0.1	-0.5	-0.1
Knee pain experienced in last month	0.0	0.0	0.1	-0.1	0.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.2	0.3	-0.2	0.4
Back pain experienced in last month	0.0	0.0	0.1	0.1	0.1	0.3

Hub : Genes

ZBTB46

Models

Trait associations