Best TWAS P=7.72e-39 · Best GWAS P=7.63e-55 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EML6 | 0.06 | 0.00 | blup | 675 | 0.03 | 9.2e-05 | -8.7 | -9.2 | 4.3e-20 | 0.00 | 0.58 | 0.01 | TRUE |
| 2 | GTEx | Artery Aorta | AC093110.3 | 0.13 | 0.14 | lasso | 8 | 0.10 | 4.5e-06 | 7.4 | 7.7 | 2.0e-14 | 0.03 | 0.99 | 0.00 | FALSE |
| 3 | GTEx | Artery Tibial | AC093110.3 | 0.11 | 0.14 | lasso | 3 | 0.14 | 2.5e-11 | 7.4 | 7.5 | 8.8e-14 | 0.03 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | AC093110.3 | 0.11 | 0.00 | lasso | 3 | 0.00 | 2.2e-01 | 6.8 | 7.9 | 2.8e-15 | 0.08 | 0.06 | 0.05 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | AC093110.3 | 0.21 | 0.13 | lasso | 6 | 0.11 | 1.3e-08 | -8.9 | 9.0 | 1.7e-19 | -0.03 | 1.00 | 0.00 | TRUE |
| 6 | GTEx | Pancreas | EML6 | 0.34 | 0.11 | lasso | 10 | 0.13 | 3.9e-06 | 7.0 | -5.8 | 7.1e-09 | 0.00 | 0.94 | 0.00 | FALSE |
| 7 | GTEx | Thyroid | EML6 | 0.26 | 0.20 | enet | 46 | 0.24 | 5.8e-18 | 6.6 | -5.8 | 5.2e-09 | 0.09 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Whole Blood | SPTBN1 | 0.13 | 0.04 | lasso | 6 | 0.08 | 5.7e-08 | -5.9 | -8.5 | 1.6e-17 | -0.13 | 0.99 | 0.00 | TRUE |
| 9 | METSIM | Adipose | EML6 | 0.05 | 0.06 | lasso | 3 | 0.05 | 1.5e-08 | 5.5 | 5.7 | 1.1e-08 | 0.00 | 1.00 | 0.00 | FALSE |
| 10 | NTR | Blood | ACYP2 | 0.02 | 0.02 | enet | 15 | 0.02 | 8.9e-07 | 1.6 | 5.6 | 2.4e-08 | 0.32 | 1.00 | 0.00 | TRUE |
| 11 | NTR | Blood | SPTBN1 | 0.06 | 0.04 | bslmm | 640 | 0.04 | 3.2e-14 | -10.0 | -12.6 | 1.4e-36 | -0.14 | 1.00 | 0.00 | TRUE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | SPTBN1 | 0.10 | 0.03 | enet | 22 | 0.06 | 1.1e-08 | 3.0 | -5.4 | 6.7e-08 | -0.15 | 0.86 | 0.00 | TRUE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | TSPYL6 | 0.07 | 0.03 | lasso | 2 | 0.05 | 6.5e-07 | -4.6 | 5.4 | 6.5e-08 | 0.12 | 0.96 | 0.00 | TRUE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | AC092839.1 | 0.10 | 0.07 | enet | 17 | 0.09 | 4.3e-12 | -8.5 | -7.7 | 1.0e-14 | 0.01 | 1.00 | 0.00 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPL23AP32 | 0.02 | 0.02 | blup | 50 | 0.02 | 1.1e-05 | -9.5 | -10.0 | 1.5e-23 | -0.03 | 0.02 | 0.98 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C2orf73 | 0.09 | 0.01 | lasso | 3 | 0.06 | 2.0e-07 | 2.6 | -5.3 | 1.1e-07 | 0.00 | 0.46 | 0.02 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EML6 | 0.14 | 0.13 | lasso | 4 | 0.13 | 1.0e-14 | -8.2 | -7.7 | 1.2e-14 | -0.01 | 0.40 | 0.60 | TRUE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPL23AP32 | 0.09 | 0.10 | lasso | 4 | 0.10 | 7.3e-11 | 5.5 | -7.8 | 4.8e-15 | -0.01 | 0.73 | 0.27 | TRUE |
| 19 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C2orf73 | 0.16 | 0.05 | enet | 12 | 0.06 | 2.4e-04 | -4.5 | -6.8 | 9.3e-12 | -0.24 | 0.48 | 0.09 | FALSE |
| 20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C2orf73 | 0.19 | 0.08 | lasso | 6 | 0.16 | 2.8e-18 | -4.4 | -5.5 | 2.8e-08 | -0.09 | 1.00 | 0.00 | TRUE |
| 21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RPL23AP32 | 0.05 | 0.03 | blup | 50 | 0.04 | 4.3e-05 | -8.8 | -10.1 | 8.0e-24 | -0.03 | 0.06 | 0.94 | FALSE |
| 22 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SPTBN1 | 0.10 | 0.04 | lasso | 3 | 0.05 | 2.1e-06 | -8.1 | -7.4 | 1.6e-13 | -0.23 | 0.84 | 0.00 | FALSE |
| 23 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPL23AP32 | 0.06 | 0.02 | enet | 6 | 0.03 | 1.7e-04 | -8.4 | -7.0 | 2.5e-12 | 0.02 | 0.06 | 0.79 | FALSE |
| 24 | The Cancer Genome Atlas | Soft Tissue Sarcoma | RPL23AP32 | 0.04 | 0.03 | blup | 50 | 0.02 | 1.2e-02 | -8.8 | -9.9 | 4.0e-23 | -0.02 | 0.01 | 0.85 | TRUE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | EML6 | 0.05 | 0.05 | lasso | 4 | 0.05 | 3.1e-05 | 5.5 | -6.2 | 4.1e-10 | 0.03 | 0.86 | 0.03 | TRUE |
| 26 | The Cancer Genome Atlas | Thyroid Carcinoma | RPL23AP32 | 0.06 | 0.04 | blup | 50 | 0.03 | 1.3e-03 | -8.5 | -9.4 | 3.7e-21 | -0.01 | 0.04 | 0.86 | FALSE |
| 27 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | SPTBN1 | 0.39 | 0.04 | blup | 163 | 0.12 | 3.6e-04 | -11.9 | -13.0 | 7.7e-39 | -0.49 | 0.04 | 0.47 | TRUE |