[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr2:53,647,729-55,895,321

Best TWAS P=7.72e-39 · Best GWAS P=7.63e-55 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
27	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	SPTBN1	0.39	0.04	blup	163	0.12	3.6e-04	-11.9	-13.0	7.7e-39	-0.49	0.04	0.47	TRUE
11	NTR	Blood	SPTBN1	0.06	0.04	bslmm	640	0.04	3.2e-14	-10.0	-12.6	1.4e-36	-0.14	1.00	0.00	TRUE
24	The Cancer Genome Atlas	Soft Tissue Sarcoma	RPL23AP32	0.04	0.03	blup	50	0.02	1.2e-02	-8.8	-9.9	4.0e-23	-0.02	0.01	0.85	TRUE
1	CommonMind	Brain Pre-frontal Cortex	EML6	0.06	0.00	blup	675	0.03	9.2e-05	-8.7	-9.2	4.3e-20	0.00	0.58	0.01	TRUE
5	GTEx	Cells Transformed fibroblasts	AC093110.3	0.21	0.13	lasso	6	0.11	1.3e-08	-8.9	9.0	1.7e-19	-0.03	1.00	0.00	TRUE
8	GTEx	Whole Blood	SPTBN1	0.13	0.04	lasso	6	0.08	5.7e-08	-5.9	-8.5	1.6e-17	-0.13	0.99	0.00	TRUE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPL23AP32	0.09	0.10	lasso	4	0.10	7.3e-11	5.5	-7.8	4.8e-15	-0.01	0.73	0.27	TRUE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EML6	0.14	0.13	lasso	4	0.13	1.0e-14	-8.2	-7.7	1.2e-14	-0.01	0.40	0.60	TRUE
25	The Cancer Genome Atlas	Thyroid Carcinoma	EML6	0.05	0.05	lasso	4	0.05	3.1e-05	5.5	-6.2	4.1e-10	0.03	0.86	0.03	TRUE
10	NTR	Blood	ACYP2	0.02	0.02	enet	15	0.02	8.9e-07	1.6	5.6	2.4e-08	0.32	1.00	0.00	TRUE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	C2orf73	0.19	0.08	lasso	6	0.16	2.8e-18	-4.4	-5.5	2.8e-08	-0.09	1.00	0.00	TRUE
13	ROSMAP	Brain Pre-frontal Cortex	TSPYL6	0.07	0.03	lasso	2	0.05	6.5e-07	-4.6	5.4	6.5e-08	0.12	0.96	0.00	TRUE
12	ROSMAP	Brain Pre-frontal Cortex	SPTBN1	0.10	0.03	enet	22	0.06	1.1e-08	3.0	-5.4	6.7e-08	-0.15	0.86	0.00	TRUE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPL23AP32	0.05	0.03	blup	50	0.04	4.3e-05	-8.8	-10.1	8.0e-24	-0.03	0.06	0.94	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPL23AP32	0.02	0.02	blup	50	0.02	1.1e-05	-9.5	-10.0	1.5e-23	-0.03	0.02	0.98	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	RPL23AP32	0.06	0.04	blup	50	0.03	1.3e-03	-8.5	-9.4	3.7e-21	-0.01	0.04	0.86	FALSE
4	GTEx	Breast Mammary Tissue (Female)	AC093110.3	0.11	0.00	lasso	3	0.00	2.2e-01	6.8	7.9	2.8e-15	0.08	0.06	0.05	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	AC092839.1	0.10	0.07	enet	17	0.09	4.3e-12	-8.5	-7.7	1.0e-14	0.01	1.00	0.00	FALSE
2	GTEx	Artery Aorta	AC093110.3	0.13	0.14	lasso	8	0.10	4.5e-06	7.4	7.7	2.0e-14	0.03	0.99	0.00	FALSE
3	GTEx	Artery Tibial	AC093110.3	0.11	0.14	lasso	3	0.14	2.5e-11	7.4	7.5	8.8e-14	0.03	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	SPTBN1	0.10	0.04	lasso	3	0.05	2.1e-06	-8.1	-7.4	1.6e-13	-0.23	0.84	0.00	FALSE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPL23AP32	0.06	0.02	enet	6	0.03	1.7e-04	-8.4	-7.0	2.5e-12	0.02	0.06	0.79	FALSE
19	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C2orf73	0.16	0.05	enet	12	0.06	2.4e-04	-4.5	-6.8	9.3e-12	-0.24	0.48	0.09	FALSE
7	GTEx	Thyroid	EML6	0.26	0.20	enet	46	0.24	5.8e-18	6.6	-5.8	5.2e-09	0.09	1.00	0.00	FALSE
6	GTEx	Pancreas	EML6	0.34	0.11	lasso	10	0.13	3.9e-06	7.0	-5.8	7.1e-09	0.00	0.94	0.00	FALSE
9	METSIM	Adipose	EML6	0.05	0.06	lasso	3	0.05	1.5e-08	5.5	5.7	1.1e-08	0.00	1.00	0.00	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C2orf73	0.09	0.01	lasso	3	0.06	2.0e-07	2.6	-5.3	1.1e-07	0.00	0.46	0.02	FALSE