TWAS hub - RPL23AP32

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0152	0.0084	1.6e-04	0.018	0.023	0.020	NA	0.019	1.2e-04	1.1e-05	4.6e-05	NA	7.7e-05
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0853	0.0335	5.8e-10	0.102	0.091	0.085	NA	0.095	1.6e-11	2.1e-10	8.4e-10	NA	7.3e-11
3	TCGA	Brain Lower Grade Glioma	0.0527	0.0283	5.6e-06	0.028	0.037	0.034	NA	0.029	3.5e-04	4.3e-05	9.5e-05	NA	2.4e-04
4	TCGA	Prostate Adenocarcinoma	0.0562	0.0330	7.1e-04	0.020	0.030	0.034	NA	0.031	3.2e-03	3.6e-04	1.7e-04	NA	2.7e-04
5	TCGA	Soft Tissue Sarcoma	0.0420	0.0290	7.3e-03	0.029	0.025	0.007	NA	0.021	7.6e-03	1.2e-02	1.1e-01	NA	2.1e-02
6	TCGA	Thyroid Carcinoma	0.0560	0.0350	3.5e-04	0.040	0.026	0.014	NA	0.017	7.7e-05	1.3e-03	1.4e-02	NA	7.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Heel T-Score	73.7	586.5	723.6	-26.7	-20.2	-26.9	-18.8	-26.1	-25.3
Heel bone mineral density (BMD) T-score, automated (left)	36.7	83.2	102.0	-10.0	-7.8	-10.1	-7.0	-9.9	-9.4
Heel bone mineral density (BMD) T-score, automated (right)	36.4	83.3	100.0	-10.0	-8.1	-10.0	-6.8	-9.9	-9.5
Hair/balding pattern: Pattern 3	7.0	10.4	11.6	-3.4	-3.1	-3.4	-2.6	-3.4	-3.4
Serious illness, injury or assault to yourself	6.2	7.6	10.9	3.3	1.8	3.1	2.1	3.0	2.8
Worrier / anxious feelings	6.0	11.2	13.3	-3.1	-3.2	-3.5	-3.6	-3.2	-3.5
Breast Cancer	4.9	11.8	14.6	-3.8	-2.8	-3.8	-2.4	-3.8	-3.8
Impedance of leg (right)	4.7	22.6	25.4	4.9	4.0	4.8	5.0	4.8	4.8
Impedance of arm (left)	4.5	21.0	23.1	4.4	4.3	4.8	4.8	4.3	4.8
Medication for cholesterol	4.4	6.7	8.1	2.1	2.9	2.8	2.8	2.2	2.7
Cardiovascular Disease	4.3	14.1	23.3	-3.1	-3.9	-3.5	-4.8	-3.2	-3.7
Medication: Ramipril	4.2	5.5	6.2	2.5	2.3	2.3	2.1	2.4	2.4
Ever had hysterectomy (womb removed)	4.1	4.6	5.8	2.3	1.9	2.4	1.6	2.4	2.2
Glaucoma (self-reported)	4.1	4.8	6.5	2.5	1.6	2.4	1.9	2.6	2.1
Guilty feelings	4.1	6.1	7.1	-2.7	-1.9	-2.6	-2.5	-2.7	-2.5
Medication: Blood pressure	4.1	7.8	13.9	-2.4	-2.7	-2.7	-3.7	-2.4	-2.7
Impedance of whole body	3.9	20.0	21.6	4.5	4.0	4.7	4.6	4.4	4.6
Worry (Nagel 2018)	3.8	8.1	8.9	-3.0	-2.6	-2.8	-2.8	-3.0	-2.9
Trunk fat percentage	3.8	15.1	18.7	4.3	2.8	4.3	3.7	4.0	4.0
Impedance of arm (right)	3.7	17.3	19.7	4.0	3.9	4.3	4.4	4.0	4.3
Eye problems/disorders: Glaucoma	3.7	4.4	6.3	2.5	1.2	2.2	1.8	2.5	2.1
Impedance of leg (left)	3.6	17.3	19.0	4.3	3.5	4.2	4.4	4.2	4.3
Medication: Atorvastatin	3.6	4.4	5.5	-2.0	-1.9	-2.3	-1.8	-2.1	-2.3
Pack years of smoking	3.4	5.0	6.6	2.6	1.4	2.4	2.1	2.4	2.3
LDL Cholesterol	3.2	5.1	5.3	2.2	2.2	2.3	2.3	2.2	2.3
Tense / ‘highly strung’	3.2	5.3	7.5	-2.7	-1.4	-2.3	-2.2	-2.6	-2.3
Medication: Amlodipine	3.1	4.4	8.6	-1.5	-2.4	-1.7	-2.9	-1.6	-2.1
Body fat percentage	3.1	12.4	15.0	3.8	2.5	3.9	3.5	3.6	3.6
Schizophrenia (2014)	3.0	6.6	12.7	1.9	3.6	2.5	2.7	1.8	2.6
Pack years adult smoking proportion	3.0	4.6	6.7	2.6	1.1	2.5	1.8	2.4	2.2
Medication: Atenolol	3.0	3.7	4.8	-1.6	-2.2	-2.0	-2.0	-1.6	-2.0
Breastfed as a baby	2.9	3.6	4.3	1.8	2.1	1.9	1.7	1.8	2.1
Headache pain in last month	2.8	4.8	7.0	-2.5	-1.4	-2.1	-2.2	-2.6	-2.0
Neuroticism	2.6	6.3	8.0	-2.8	-1.6	-2.4	-2.7	-2.7	-2.5
Ever depressed for a whole week	2.6	3.2	3.6	-1.9	-1.4	-1.8	-1.9	-1.9	-1.9
Fasting Glucose	2.5	3.0	4.5	1.8	1.5	1.6	2.1	1.8	1.5
Osteoporosis (self-reported)	2.5	3.1	4.2	1.9	1.6	2.0	0.9	1.9	2.0
Exposure to tobacco smoke outside home	2.4	3.2	4.2	1.6	1.9	2.1	1.5	1.6	2.0
Relative age of first facial hair	2.3	4.8	7.4	-2.5	-1.2	-2.4	-1.7	-2.7	-2.2
Father’s age at death	2.3	3.1	4.4	1.6	2.1	1.8	1.7	1.4	1.9
Mineral and other dietary supplements	2.3	3.1	4.2	2.0	1.2	2.0	1.2	1.9	1.9
Supplements: Fish oil (including cod liver oil)	2.3	3.0	4.3	-2.1	-0.9	-2.1	-1.2	-2.0	-1.8
Illnesses of father: High blood pressure	2.3	2.8	3.2	-1.7	-1.7	-1.7	-1.5	-1.8	-1.7
Hayfever, allergic rhinitis or eczema	2.2	4.8	6.9	-2.6	-1.4	-2.4	-1.9	-2.5	-2.1
High blood pressure (mother)	2.2	3.1	4.2	-1.9	-1.5	-1.6	-2.1	-1.9	-1.6
Neuroticism score	2.2	4.6	6.2	-2.2	-1.7	-2.1	-2.5	-2.2	-2.1
Medication: Ventolin 100micrograms inhaler	2.2	2.8	3.6	1.6	1.8	1.5	1.7	1.9	1.4
Leg fat percentage (right)	2.2	8.0	10.2	3.2	1.8	3.1	2.8	3.1	2.8
Hypertension (Self-reported)	2.2	6.0	12.8	-1.7	-2.6	-2.1	-3.6	-1.8	-2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.4	3.0	1.6	1.6	1.7	1.2	1.6	1.6
Average weekly red wine intake	2.1	3.1	4.5	-2.1	-1.1	-2.0	-1.2	-1.9	-1.8
HbA1C	2.0	2.2	3.1	1.8	0.3	1.5	1.7	1.7	1.4
Exposure to tobacco smoke at home	2.0	2.3	3.1	1.3	1.8	1.6	1.3	1.2	1.8
Family relationship satisfaction	2.0	2.5	3.6	1.1	1.9	1.6	1.8	1.1	1.8
Neuroticism (Nagel 2018)	1.9	4.5	5.0	-2.1	-2.1	-2.0	-2.2	-2.1	-2.1
Alzheimer’s Disease (in father)	1.9	2.1	3.0	1.4	1.6	1.7	0.8	1.5	1.5
Blood Red Count	1.9	18.5	24.6	4.6	4.2	5.0	2.1	4.6	4.6
Trunk fat mass	1.9	8.2	10.8	3.3	1.6	3.3	2.8	3.0	2.9
Loneliness, isolation	1.9	2.6	3.9	-1.6	-1.5	-1.5	-2.0	-1.3	-1.7
Schizophrenia (2018)	1.8	3.8	7.1	1.5	2.7	2.0	2.0	1.4	1.9
Body Mass Index (BMI) (2010)	1.8	2.5	3.9	-1.4	-1.5	-1.5	-2.0	-1.6	-1.5
Severe depression (siblings)	1.8	2.0	2.7	-1.5	-1.4	-1.6	-0.9	-1.4	-1.6
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	3.0	-1.7	-1.0	-1.4	-1.4	-1.7	-1.5
Falls in the last year	1.8	2.5	3.6	1.5	1.4	1.4	1.9	1.6	1.5
Medication: Bendroflumethiazide	1.8	2.7	5.5	-1.4	-1.5	-1.6	-2.4	-1.4	-1.4
Pulse wave peak to peak time	1.7	2.0	5.4	1.1	1.3	1.1	2.3	1.0	1.1
Leg fat percentage (left)	1.7	6.3	8.2	2.9	1.5	2.8	2.4	2.8	2.5
Primary Biliary Cirrhosis	1.6	2.2	3.3	-1.6	-1.0	-1.8	-1.0	-1.8	-1.5
Systolic Blood Pressure	1.6	8.1	12.6	-2.5	-2.7	-2.8	-3.5	-2.4	-3.0
Prospective memory result	1.6	1.9	4.4	-1.4	-0.8	-1.2	-2.1	-1.3	-1.3
Mouth/teeth dental problems: Loose teeth	1.6	1.9	4.9	-0.7	-2.2	-1.1	-1.5	-0.8	-1.4
Fractured/broken bones in last 5 years	1.6	2.0	3.0	1.7	0.5	1.6	1.7	1.5	1.1
Vascular/heart problems diagnosed by doctor	1.6	4.3	10.6	1.6	1.9	1.7	3.3	1.6	1.9
Heart attack/myocardial infarction (self-reported)	1.6	2.1	4.2	1.0	2.0	1.4	1.3	0.9	1.6
Allergy or Eczema	1.5	4.1	6.7	-2.6	-0.7	-2.1	-1.8	-2.6	-1.7
Average weekly spirits intake	1.5	1.9	3.3	1.4	0.8	1.3	1.8	1.3	1.4
Diabetes (mother)	1.5	1.9	2.7	1.6	1.2	1.6	0.8	1.4	1.6
Had other major operations	1.5	1.8	2.8	1.7	0.8	1.5	1.0	1.6	1.4
Heart attack	1.5	1.9	3.9	0.9	2.0	1.4	1.1	0.8	1.6
Whole body fat mass	1.5	6.3	8.1	2.8	1.4	2.8	2.6	2.6	2.5
Arm fat percentage (left)	1.5	6.0	7.4	2.6	1.8	2.7	2.5	2.5	2.4
Bipolar Disorder or Schizophrenia	1.4	3.4	7.4	1.3	2.7	1.8	1.9	1.2	1.8
Current tobacco smoking	1.4	2.2	3.9	2.0	0.0	1.8	0.6	2.0	1.4
Chronic bronchitis/emphysema (mother)	1.4	1.7	3.0	0.7	1.7	1.3	1.5	0.6	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	4.7	-0.7	-1.5	-1.0	-2.2	-0.7	-1.0
Knee pain experienced in last month	1.4	2.1	3.2	1.2	1.8	1.4	1.6	1.2	1.4
Mother’s age at death	1.4	1.7	4.0	0.9	2.0	1.3	1.2	1.0	1.2
Age at First Birth	1.3	1.8	2.4	-1.5	-1.1	-1.4	-1.1	-1.4	-1.6
Qualifications: CSEs or equivalent	1.3	1.7	2.5	-1.4	-1.1	-1.6	-0.3	-1.4	-1.5
Number of incorrect matches in round	1.3	2.1	3.7	-0.9	-1.9	-1.4	-1.7	-0.7	-1.7
Arm fat percentage (right)	1.3	5.2	6.4	2.4	1.6	2.5	2.3	2.4	2.3
Pulse wave Arterial Stiffness index	1.3	1.5	4.4	-0.8	-1.3	-0.8	-2.1	-0.8	-0.9
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	2.9	-1.7	-0.7	-1.6	-0.9	-1.7	-1.5
Comparative body size at age 10	1.3	3.5	5.7	-2.4	-1.1	-2.0	-1.1	-2.3	-1.9
Average weekly champagne plus white wine intake	1.3	1.8	2.4	-1.3	-1.5	-1.5	-0.8	-1.3	-1.6
Schizophrenia vs Biploar Disorder	1.2	1.6	2.3	1.3	1.1	1.5	1.0	1.2	1.4
Mouth/teeth dental problems: Dentures	1.2	2.0	3.2	1.3	1.8	1.7	0.6	1.2	1.6
Depression (self-reported)	1.2	1.5	2.7	1.6	0.3	1.4	0.5	1.5	1.2
Lung cancer (father)	1.2	1.4	2.5	1.4	0.7	1.3	0.8	1.6	1.0
Heart disease (mother)	1.2	1.5	2.1	-1.2	-1.5	-1.2	-1.2	-1.0	-1.3
Hearing aid user	1.2	1.4	4.5	-0.3	-2.1	-1.2	0.5	-0.3	-1.4
Average weekly beer plus cider intake	1.2	1.8	2.5	-1.5	-1.4	-1.4	-0.7	-1.6	-1.3
Reaction Time	1.1	2.0	2.7	-1.7	-0.8	-1.6	-1.5	-1.7	-1.3
Angina	1.1	1.4	1.9	-1.4	-0.9	-1.2	-1.1	-1.4	-1.1
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	3.5	0.4	1.9	1.0	0.7	0.7	1.2
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	1.9	-1.4	-0.9	-1.3	-0.5	-1.3	-1.2
Smoking status: Current	1.1	1.7	3.2	1.7	-0.0	1.6	0.4	1.8	1.2
Commuting to job workplace: Public transport	1.1	1.4	1.6	1.2	1.1	1.3	1.0	1.1	1.3
High blood pressure	1.0	2.8	7.8	-0.9	-1.7	-1.3	-2.8	-1.0	-1.5
Illnesses of mother	1.0	1.2	1.5	1.1	1.2	1.1	1.2	1.1	0.8
Angina (self-reported)	1.0	1.3	1.9	-1.4	-0.8	-1.1	-1.1	-1.3	-1.1
Leg fat mass (right)	1.0	3.8	5.3	2.3	0.8	2.2	2.0	2.1	1.9
Number of treatments/medications taken	0.9	1.6	2.3	-1.0	-1.5	-1.3	-1.5	-1.0	-1.3
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	1.5	1.1	1.2	1.0	1.2	1.1	1.1
Medication: Simvastatin	0.9	1.4	2.4	1.5	0.7	1.3	0.2	1.5	1.2
Smoking status: Previous	0.9	1.3	2.2	-1.4	-0.3	-1.5	0.2	-1.2	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	2.4	-1.3	-0.9	-1.5	-0.2	-1.4	-1.4
Prostate Cancer	0.8	1.2	3.3	-0.4	-1.8	-0.8	-1.1	-0.3	-1.3
Height	0.8	14.8	24.9	5.0	0.9	4.2	3.9	4.1	3.7
Medication: Paracetamol	0.8	1.4	2.4	-1.4	-0.8	-1.1	-0.9	-1.5	-1.0
Pulse rate, automated reading	0.8	2.5	4.3	2.0	0.8	1.7	1.0	2.1	1.4
Commuting to job workplace: Car/motor vehicle	0.8	1.0	1.7	-0.7	-1.3	-0.9	-1.0	-0.9	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	2.9	1.7	0.7	1.3	1.0	1.6	1.3
Leg fat mass (left)	0.8	2.9	4.2	2.1	0.6	1.9	1.8	1.9	1.6
Alzheimer’s Disease (in mother)	0.7	0.8	1.7	-0.6	-1.3	-0.9	-0.8	-0.9	-0.7
Major Depression (MDD)	0.7	0.8	2.5	0.3	1.6	1.0	0.2	0.2	1.1
Hearing difficulty/problems: Yes	0.7	1.1	4.1	0.9	-0.7	0.1	2.0	1.0	-0.2
Townsend deprivation index at recruitment	0.7	0.9	1.8	-1.2	-0.2	-0.7	-1.4	-1.2	-0.5
Pulse rate	0.7	1.2	2.6	-0.5	-1.6	-0.9	-1.5	-0.5	-0.9
Number of full brothers	0.7	0.8	1.4	0.7	1.1	1.2	0.9	0.6	1.0
Medication for pain relief, constipation, heartburn	0.7	1.2	1.9	1.3	0.9	1.0	1.2	1.4	0.9
Mean Putamen Volume	0.6	0.7	1.5	-0.7	-1.0	-0.6	-1.2	-0.7	-0.6
Ulcerative Colitis	0.6	0.8	1.7	-0.7	-1.3	-1.0	-0.7	-0.7	-1.0
Blood Eosinophil Count	0.6	4.5	7.1	-2.1	-2.3	-2.7	-0.0	-2.0	-2.5
Respiratory disease	0.6	1.4	2.3	1.0	1.5	1.4	0.4	1.1	1.3
Age when periods started (menarche)	0.6	1.5	3.5	0.7	1.9	1.2	1.3	0.6	1.3
Hair/balding pattern: Pattern 2	0.6	0.7	1.8	0.6	1.3	0.8	-0.0	0.5	1.1
Asthma	0.6	1.1	2.3	0.7	1.5	1.3	0.2	0.8	1.2
Peak expiratory flow (PEF)	0.6	1.4	2.6	1.6	0.4	1.3	0.9	1.4	1.2
Pulse wave reflection index	0.6	0.7	1.4	-1.0	-0.1	-0.6	-1.2	-1.0	-0.5
Neck or shoulder pain in last month	0.6	0.8	1.3	-1.2	-0.0	-0.8	-1.1	-1.0	-0.9
Arm predicted mass (right)	0.6	2.8	6.6	-1.1	-2.6	-1.4	-1.7	-1.4	-1.7
Alcohol intake frequency.	0.6	1.4	2.4	0.9	1.4	1.6	0.6	0.9	1.3
Leg fat-free mass (right)	0.6	3.1	5.3	-1.4	-2.3	-1.6	-1.8	-1.7	-1.8
Diabetes diagnosed by doctor	0.6	1.0	1.9	0.9	1.4	1.2	0.1	0.9	1.1
Leg predicted mass (right)	0.6	3.2	5.3	-1.4	-2.3	-1.6	-1.8	-1.7	-1.8
Alcohol drinker status: Never	0.6	0.7	1.5	-1.0	-0.5	-0.9	-0.3	-1.2	-0.9
Irritability	0.6	1.0	1.5	-1.2	-0.8	-1.0	-0.7	-1.1	-1.1
Risk taking	0.6	0.8	1.3	-0.9	-0.9	-0.7	-1.1	-1.0	-0.8
Basal cell carcinoma (self-reported)	0.6	0.8	1.1	-1.0	-0.8	-0.7	-1.0	-1.0	-0.8
Depressed Affect (Nagel 2018)	0.5	1.0	1.8	-1.0	-0.9	-0.9	-1.3	-0.9	-1.0
Depression (Nagel 2018)	0.5	0.7	1.6	-0.7	-1.3	-0.7	-0.8	-0.7	-0.9
Bipolar Disorder (2011)	0.5	0.5	1.8	0.1	1.3	0.3	0.8	0.2	0.6
Vitamin and mineral supplements	0.5	0.6	1.0	1.0	-0.1	1.0	-0.3	1.0	0.9
Medication: Metformin	0.5	0.7	1.7	0.6	1.3	0.9	0.3	0.6	0.9
Maternal smoking around birth	0.5	0.7	1.3	-0.8	-0.7	-1.1	-0.5	-0.7	-1.1
Allergy	0.5	1.2	2.0	1.4	0.3	1.1	1.1	1.2	1.1
Trunk fat-free mass	0.5	3.1	5.7	-1.3	-2.4	-1.6	-1.7	-1.6	-1.8
Alcohol intake versus 10 years previously	0.5	0.7	1.1	0.9	0.5	1.1	0.6	0.9	0.9
Trunk predicted mass	0.5	3.1	5.8	-1.3	-2.4	-1.6	-1.7	-1.6	-1.8
Arm fat-free mass (right)	0.5	2.5	5.8	-1.1	-2.4	-1.4	-1.4	-1.3	-1.6
Eye problems/disorders: None of the above	0.5	0.5	1.2	-0.6	-0.8	-0.4	-1.1	-0.7	-0.5
Migraine (self-reported)	0.5	0.6	1.4	-0.7	-1.2	-0.6	-0.7	-0.8	-0.5
Medication: Allopurinol	0.5	0.7	1.0	-1.0	-0.6	-0.9	-0.5	-0.9	-0.9
Whole body fat-free mass	0.5	2.8	6.0	-1.2	-2.4	-1.5	-1.6	-1.5	-1.7
Whole body water mass	0.5	3.1	6.1	-1.3	-2.5	-1.6	-1.7	-1.6	-1.8
Wears glasses or contact lenses	0.5	0.6	1.4	0.5	1.1	0.4	1.2	0.6	0.6
Financial situation satisfaction	0.5	0.6	1.4	0.6	0.6	0.7	1.2	0.4	0.9
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.6	0.5	-0.5	0.4	1.6	0.5	-0.1
Arm fat-free mass (left)	0.5	2.7	6.1	-1.0	-2.5	-1.4	-1.7	-1.3	-1.6
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.2	-0.6	-0.6	-0.7	-1.1	-0.7	-0.8
Myopia	0.5	0.7	1.4	-1.2	0.1	-1.0	0.2	-1.2	-0.8
Ovarian Cancer	0.4	0.5	0.8	-0.6	-0.8	-0.6	-0.9	-0.5	-0.9
Blood White Count	0.4	3.1	4.8	1.8	1.0	1.6	2.2	2.2	1.5
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.3	0.8	1.1	1.1	0.3	0.7	1.0
Tanning	0.4	4.7	9.2	2.3	0.7	2.1	3.0	2.5	1.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.6	0.0	1.3	0.3	0.6	0.0	0.6
Multivitamins +/- minerals	0.4	0.5	0.8	-0.9	0.5	-0.8	0.3	-0.8	-0.6
Diabetes (self-reported)	0.4	0.7	1.1	0.8	1.0	1.0	0.2	0.9	0.8
Number of live births	0.4	0.5	1.4	0.5	1.2	0.6	0.2	0.5	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.9	0.1	-1.0	-0.4	-0.9	0.1	-0.8
Health satisfaction	0.4	0.5	0.7	0.7	0.6	0.8	0.7	0.7	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.6	-0.7	-0.1	-0.7	-0.8	-0.8	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.9	0.2	0.8	0.5	0.9	0.2	0.8
Arm fat mass (left)	0.4	1.8	2.5	1.6	0.5	1.6	1.4	1.4	1.3
Diastolic blood pressure, automated reading	0.4	1.3	2.3	1.5	0.0	1.3	-0.9	1.5	0.8
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	0.8	0.5	0.9	0.0	0.7	1.0
Heart disease (siblings)	0.4	0.5	1.4	0.2	1.2	0.6	0.6	0.3	0.6
Alcohol drinker status: Previous	0.4	0.4	1.0	0.2	1.0	0.8	-0.1	0.2	0.8
Arm predicted mass (left)	0.4	2.1	5.4	-0.7	-2.3	-1.2	-1.5	-1.1	-1.4
Lupus	0.3	0.4	0.6	-0.8	-0.4	-0.4	-0.8	-0.8	-0.4
Waist Hip Ratio (WHR)	0.3	1.3	2.2	1.5	0.5	1.2	0.2	1.4	1.2
Chronotype (morning person)	0.3	0.7	2.8	0.4	0.7	0.3	1.7	0.7	0.4
Medication: Co-codamol	0.3	0.4	1.1	-0.7	-0.2	-0.4	-1.1	-0.7	-0.4
Leg fat-free mass (left)	0.3	1.6	3.7	-0.8	-1.9	-1.0	-1.1	-1.1	-1.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.0	-0.3	-0.6	-0.4	-1.0	-0.3	-0.5
Stomach or abdominal pain in last month	0.3	0.4	1.9	-0.4	0.6	-0.2	1.4	-0.3	-0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.9	-0.8	0.2	-0.6	-0.3	-0.9	-0.4
Sitting height	0.3	2.0	3.7	1.9	-1.1	1.2	1.4	1.6	1.1
Chronic bronchitis/emphysema (father)	0.3	0.3	0.6	0.4	0.7	0.6	0.3	0.3	0.8
Leg predicted mass (left)	0.3	1.5	3.6	-0.8	-1.9	-1.0	-1.1	-1.1	-1.2
Waist circumference	0.3	1.2	2.2	1.5	0.1	1.2	1.0	1.4	0.9
Past tobacco smoking	0.3	0.6	1.3	0.9	0.2	1.1	-0.3	0.7	1.1
Had menopause	0.3	0.4	0.5	0.7	0.5	0.7	0.6	0.7	0.6
Qualifications: None of the above	0.3	0.7	1.3	1.1	0.3	1.0	0.5	1.1	0.8
Hip circumference	0.3	1.1	1.9	1.4	-0.0	1.2	1.2	1.1	0.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.2	1.5	-0.7	0.9	0.9	1.2	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.6	-0.7	-0.2	-0.5	-0.8	-0.8	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.0	1.4	-0.7	0.9	1.2	1.1	0.8
Arm fat mass (right)	0.3	1.3	2.1	1.4	0.2	1.4	1.0	1.3	1.1
Length of working week for main job	0.3	0.3	0.7	-0.7	0.4	-0.3	-0.9	-0.7	-0.1
Birth weight of first child	0.3	0.6	2.3	-0.2	1.5	0.6	-0.0	-0.4	0.9
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.3	0.3	0.7	0.5	1.1	0.3	0.7
Forced vital capacity (FVC), Best measure	0.3	1.0	2.0	1.4	-0.6	0.9	0.8	1.1	0.9
Wheeze or whistling in the chest in last year	0.3	0.5	0.8	0.8	0.5	0.8	0.5	0.9	0.6
Shortness of breath walking on level ground	0.3	0.4	1.0	-1.0	-0.1	-0.6	-0.1	-0.7	-0.6
Medication: Blood pressure	0.3	0.5	1.3	0.0	-1.1	-0.6	-1.0	-0.1	-0.7
Number of full sisters	0.3	0.3	0.7	-0.8	-0.1	-0.5	-0.5	-0.8	-0.3
Age at last live birth	0.3	0.5	0.9	-0.7	-0.4	-0.9	-0.7	-0.8	-0.6
Mood swings	0.3	0.5	0.7	-0.8	-0.4	-0.7	-0.8	-0.7	-0.7
Friendships satisfaction	0.3	0.3	0.5	-0.6	-0.2	-0.7	0.3	-0.7	-0.7
Qualifications: nursing, teaching	0.3	0.5	2.0	-0.1	1.4	0.2	0.6	-0.3	0.5
Breast cancer (self-reported)	0.3	0.3	0.6	-0.5	-0.4	-0.7	-0.4	-0.5	-0.8
Asthma (self-reported)	0.3	0.7	1.5	0.5	1.2	1.1	0.1	0.6	0.9
Medication: Paracetamol	0.3	0.5	1.0	-0.9	-0.4	-0.6	-0.6	-1.0	-0.5
Medication: Lisinopril	0.3	0.4	1.0	0.5	-1.0	0.2	-0.7	0.8	-0.3
Basal metabolic rate	0.3	1.5	4.2	-0.7	-2.0	-0.9	-1.1	-1.0	-1.2
Number of operations (self-reported)	0.3	0.5	1.0	1.0	0.2	0.7	0.4	0.9	0.7
Supplements: Calcium	0.3	0.3	0.8	-0.4	-0.5	-0.4	-0.9	-0.4	-0.7
Bipolar Disorder (2018)	0.2	0.3	1.0	0.2	1.0	0.4	0.6	0.1	0.4
Rheumatoid Arthritis	0.2	0.3	1.1	-0.1	-1.0	-0.4	-0.2	0.0	-0.8
Lung FVC	0.2	0.9	1.7	1.3	0.0	0.9	0.7	1.2	1.1
Hand grip strength (left)	0.2	0.4	1.3	-0.0	-1.1	-0.2	-1.0	-0.2	-0.4
Sensitivity / hurt feelings	0.2	0.4	0.8	-0.5	-0.9	-0.5	-0.4	-0.6	-0.8
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.4	-0.4	-0.7	-0.3	-0.6	-0.3	-0.4
Supplements: Zinc	0.2	0.2	0.4	-0.3	-0.5	-0.5	-0.0	-0.3	-0.6
Hand grip strength (right)	0.2	0.5	1.5	-0.2	-1.0	-0.3	-1.2	-0.4	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	1.1	-0.0	-1.0	-0.2	-0.2	0.0	-0.4
Relative age voice broke	0.2	0.3	0.7	-0.6	0.4	-0.3	-0.7	-0.8	-0.3
Hearing difficulty/problems with background noise	0.2	0.3	0.8	-0.2	-0.9	-0.7	0.4	-0.4	-0.6
Forced vital capacity (FVC)	0.2	0.8	1.8	1.3	-0.8	0.8	0.5	1.0	0.7
Financial difficulties in last 2 years	0.2	0.3	0.4	0.6	0.1	0.6	0.4	0.5	0.7
Medication: Lansoprazole	0.2	0.3	0.6	0.7	-0.1	0.6	-0.4	0.5	0.5
Standing height	0.2	2.4	4.2	2.0	0.1	1.7	1.6	1.4	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.8	-0.1	-0.4	-0.4	-0.7	-0.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	0.6	0.6	0.5	0.2	0.5	0.4
Blood clot in the leg (DVT)	0.2	0.3	0.8	-0.5	-0.9	-0.4	-0.1	-0.4	-0.7
High blood pressure (siblings)	0.2	0.3	1.3	0.2	0.4	0.4	-1.2	0.2	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.8	-0.1	-0.3	-0.6	-0.8	-0.3
Number of children fathered	0.2	0.2	0.4	-0.5	-0.1	-0.6	0.1	-0.4	-0.7
Medication: Omeprazole	0.2	0.2	0.4	0.5	0.2	0.6	-0.2	0.4	0.6
Suffer from ‘nerves’	0.2	0.3	0.5	-0.5	-0.7	-0.3	-0.6	-0.6	-0.4
Overall health rating	0.2	0.5	0.7	-0.6	-0.8	-0.5	-0.8	-0.8	-0.6
Leg pain on walking	0.2	0.2	0.3	0.4	0.5	0.6	0.1	0.5	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.9	0.3	0.1	0.4	0.9	0.4	0.3
Supplements: Vitamin C	0.2	0.3	0.6	-0.4	-0.7	-0.6	0.2	-0.3	-0.8
Illnesses of father: Heart disease	0.2	0.3	0.4	0.6	0.5	0.6	0.2	0.7	0.5
Illnesses of siblings: Diabetes	0.2	0.2	0.3	0.4	0.6	0.6	0.2	0.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.6	0.8	-0.8	0.7	0.0	0.3	0.6
Eye problems/disorders: Cataract	0.2	0.2	0.7	-0.2	0.8	-0.3	0.8	-0.1	-0.1
Medication: Gliclazide	0.2	0.2	0.7	-0.2	-0.6	-0.2	-0.8	-0.0	-0.5
Miserableness	0.2	0.4	0.9	-0.9	0.4	-0.4	-0.7	-0.9	-0.3
Ever taken oral contraceptive pill	0.2	0.2	1.2	0.2	-0.5	-0.1	1.1	0.1	-0.0
High cholesterol (Self-reported)	0.2	0.4	0.6	0.8	0.6	0.5	-0.0	0.7	0.6
Cholesterol lowering medication	0.2	0.2	0.5	-0.2	-0.7	-0.5	-0.5	-0.3	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.6	-0.4	-0.8	-0.3	-0.1	-0.4	-0.6
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.7	0.4	0.4	0.8	0.4	0.3	0.8
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.3	-0.5	0.2	-0.2	0.2	0.2
Crohns Disease (2017)	0.1	0.3	0.5	0.7	-0.5	0.6	0.3	0.7	0.5
Irritable Bowel Disease (IBD)	0.1	0.1	0.5	0.4	-0.7	0.1	0.3	0.4	0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	0.3	0.2	0.6	0.1	0.3	0.6
Coronary Artery Disease (CAD)	0.1	0.1	0.3	0.3	-0.5	0.1	0.6	0.1	-0.2
Crohns Disease (2012)	0.1	0.1	0.4	0.2	-0.6	0.3	-0.2	0.1	0.1
HDL Cholesterol	0.1	0.1	0.4	-0.0	0.6	0.2	0.3	-0.0	0.3
BMI	0.1	0.4	0.7	-0.4	-0.8	-0.4	-0.8	-0.6	-0.5
Smoking Status	0.1	0.3	0.6	0.7	-0.7	0.3	0.2	0.8	-0.2
Hypothyroidism (self reported)	0.1	0.1	0.4	-0.4	-0.3	-0.3	0.6	-0.3	-0.2
Lung FEV1/FVC ratio	0.1	0.3	0.8	-0.1	-0.9	-0.4	0.8	-0.1	-0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.1	-0.6	-0.4	0.1	0.2	-0.5
Systolic blood pressure, automated reading	0.1	0.4	1.3	-0.1	-0.6	-0.4	-1.1	0.1	-0.6
Medication for hormone replacement therapy	0.1	0.1	0.4	-0.0	-0.6	-0.5	-0.1	-0.1	-0.4
Diabetes (father)	0.1	0.1	0.4	0.4	0.1	0.6	0.0	0.2	0.4
Fed-up feelings	0.1	0.2	0.6	-0.1	-0.5	-0.1	-0.8	-0.1	-0.2
Taking other prescription medications	0.1	0.2	0.4	0.5	0.5	0.5	0.2	0.6	0.4
Supplements: Glucosamine	0.1	0.1	0.5	0.1	0.4	-0.1	0.7	0.3	-0.0
Medication: Levothyroxine sodium	0.1	0.1	0.6	-0.1	-0.0	-0.1	0.8	-0.0	-0.0
Nervous feelings	0.1	0.2	0.7	-0.3	-0.1	-0.0	-0.9	-0.3	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	-0.6	0.2	-0.3	-0.5	-0.5	-0.2
Pain all over the body in last month	0.1	0.1	0.2	-0.1	-0.5	-0.4	-0.2	-0.2	-0.2
Fluid intelligence score	0.1	0.2	0.6	-0.1	-0.8	-0.2	-0.5	-0.2	-0.2
Illnesses of siblings	0.1	0.2	0.8	0.2	-0.3	-0.2	0.9	0.1	-0.0
Weight	0.1	0.4	0.8	0.9	-0.7	0.8	0.4	0.6	0.4
Time employed in main current job	0.1	0.1	0.6	-0.1	-0.2	-0.3	-0.8	-0.1	-0.2
Noisy workplace	0.1	0.2	0.3	-0.4	-0.5	-0.3	-0.4	-0.3	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.1	-0.1	1.0	0.2	0.5	-0.3	0.4
Medication: Cholesterol lowering	0.1	0.2	0.3	0.5	0.6	0.5	-0.1	0.5	0.4
Hair/balding pattern: Pattern 4	0.1	0.3	0.5	-0.4	-0.6	-0.7	0.4	-0.4	-0.7
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.5	-0.3	0.7	0.0	0.5	-0.1	0.1
Loud music exposure frequency	0.1	0.1	0.3	-0.4	-0.1	-0.5	0.3	-0.5	-0.4
Gout (self-reported)	0.1	0.2	0.3	-0.6	-0.2	-0.4	-0.2	-0.5	-0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	1.1	-0.2	-0.2	-0.3	1.1	-0.0	-0.3
Birth weight	0.1	0.2	0.4	-0.1	0.7	0.3	-0.4	-0.3	0.6
Medication: Ibuprofen	0.1	0.1	0.3	-0.3	-0.0	-0.0	-0.5	-0.2	0.0
Comparative height size at age 10	0.1	0.5	0.7	0.9	-0.8	0.6	0.8	0.6	0.4
Chest pain or discomfort	0.1	0.1	0.3	-0.5	0.4	-0.1	-0.2	-0.5	-0.0
Had major operations	0.1	0.1	0.4	0.1	-0.6	-0.2	0.1	0.2	-0.4
Medication: Aspirin	0.1	0.2	0.2	-0.3	-0.5	-0.5	-0.4	-0.4	-0.4
Long-standing illness, disability or infirmity	0.1	0.2	0.5	-0.4	-0.0	0.0	-0.7	-0.5	-0.1
Commuting to job workplace: Walk	0.1	0.1	0.3	0.3	-0.6	0.1	0.2	0.3	-0.1
Back pain experienced in last month	0.1	0.2	0.4	-0.3	-0.7	-0.3	-0.6	-0.5	-0.4
Osteoarthritis (self-reported)	0.1	0.2	0.4	0.5	0.3	0.3	0.6	0.4	0.3
Medication: Aspirin	0.1	0.1	0.2	-0.1	-0.4	-0.3	-0.2	-0.2	-0.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.7	-0.2	-0.2	-0.3	-0.8	-0.0	-0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.7	-0.1	-0.2	-0.2	-0.8	-0.0	-0.3
Ever smoked	0.1	0.2	0.6	-0.2	-0.2	-0.5	0.8	-0.1	-0.5
Pain experienced in last month	0.1	0.2	0.3	0.5	0.2	0.3	0.4	0.5	0.3
Ulcerative Colitis (UC)	0.0	0.1	0.4	-0.1	-0.6	-0.3	0.1	-0.1	-0.2
Neuroticism (2016)	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.4	-0.1	-0.1
Triglycerides	0.0	0.0	0.1	0.3	0.0	0.1	-0.1	0.2	0.1
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	-0.1	0.0	-0.1	0.3	-0.1	-0.3
Blood Platelet Count	0.0	0.2	0.9	-0.1	1.0	-0.0	-0.3	-0.2	0.5
Hair Pigment	0.0	0.4	1.0	0.4	1.0	0.4	-0.5	0.6	0.7
Average weekly fortified wine intake	0.0	0.1	0.2	0.1	-0.5	0.1	-0.1	0.3	0.1
Body mass index (BMI)	0.0	0.1	0.4	0.0	-0.7	0.0	-0.3	-0.0	-0.2
Alcohol usually taken with meals	0.0	0.1	0.1	0.3	0.1	0.2	-0.1	0.3	0.3
Mouth/teeth dental problems	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.2	0.0	0.1
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.2	-0.1	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.0	0.1	-0.0	0.2	-0.1	0.2	0.0
Happiness	0.0	0.1	0.1	0.0	0.4	0.1	0.2	-0.0	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.1	0.1	0.2	-0.1	0.2	-0.4	0.3	-0.1
Worry too long after embarrassment	0.0	0.1	0.3	0.2	0.3	0.1	-0.5	0.1	0.2
Age at first live birth	0.0	0.0	0.1	-0.1	-0.1	-0.3	-0.4	-0.1	-0.2
Qualifications: College or University degree	0.0	0.1	0.3	-0.2	0.3	-0.1	0.5	-0.1	0.1
Emphysema/chronic bronchitis	0.0	0.1	0.2	0.1	0.4	0.2	0.1	0.2	0.2
Medication: Seretide 50 evohaler	0.0	0.0	0.1	0.1	-0.1	0.2	0.1	-0.0	0.2
Mean time to correctly identify matches	0.0	0.1	0.2	-0.3	0.5	-0.2	-0.3	-0.2	0.2
Handedness (chirality/laterality): Left-handed	0.0	0.1	0.3	-0.1	0.5	-0.0	0.2	-0.1	-0.1
Ever had bowel cancer screening	0.0	0.0	0.2	-0.2	0.2	0.0	0.4	-0.1	-0.0
Illnesses of father: None of the above (group 1)	0.0	0.0	0.0	0.0	-0.0	-0.2	-0.0	-0.1	-0.0
Age started oral contraceptive pill	0.0	0.0	0.1	-0.2	0.1	-0.1	0.0	-0.2	-0.3
Unable to work because of sickness or disability	0.0	0.0	0.1	-0.0	0.3	0.3	0.2	-0.1	0.2
Commuting to job workplace: Cycle	0.0	0.1	0.2	-0.2	0.4	-0.0	-0.2	-0.1	0.0

Hub : Genes

RPL23AP32

Models

Trait associations