Hub : Genes

EML6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0580	0.0200	1.6e-04	0.003	0.031	0.007	0.028	0.005	1.1e-01	9.2e-05	4.7e-02	2.0e-04	7.4e-02
2	GTEx	Artery Tibial	0.2412	0.0527	7.4e-11	0.165	NA	0.219	NA	0.221	6.5e-13	NA	4.1e-17	NA	2.9e-17
3	GTEx	Esophagus Gastroesophageal Junction	0.2970	0.1100	3.7e-04	-0.007	NA	0.001	NA	-0.001	7.1e-01	NA	2.9e-01	NA	3.6e-01
4	GTEx	Esophagus Muscularis	0.3480	0.0600	3.1e-13	0.353	NA	0.359	NA	0.361	2.7e-22	NA	8.7e-23	NA	6.9e-23
5	GTEx	Pancreas	0.3420	0.0720	7.1e-07	0.106	NA	0.121	NA	0.130	3.1e-05	NA	8.7e-06	NA	3.9e-06
6	GTEx	Thyroid	0.2650	0.0510	5.6e-17	0.196	NA	0.235	NA	0.211	6.1e-15	NA	5.8e-18	NA	4.8e-16
7	METSIM	Adipose	0.0549	0.0176	1.3e-05	0.065	0.041	0.048	0.046	0.054	5.7e-10	7.0e-07	9.1e-08	1.7e-07	1.5e-08
8	ROSMAP	Brain Pre-frontal Cortex	0.0903	0.0294	6.2e-05	0.065	0.025	0.042	0.036	0.058	8.0e-09	3.4e-04	3.9e-06	1.7e-05	5.3e-08
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.1416	0.0404	5.3e-10	0.132	0.086	0.105	NA	0.133	1.3e-14	6.8e-10	8.2e-12	NA	1.0e-14
10	TCGA	Ovarian Serous Cystadenocarcinoma	0.1700	0.0600	1.2e-03	0.066	0.039	0.067	NA	0.055	2.8e-05	1.1e-03	2.5e-05	NA	1.3e-04
11	TCGA	Thyroid Carcinoma	0.0500	0.0220	5.0e-03	0.050	0.013	0.039	NA	0.045	1.3e-05	1.6e-02	9.9e-05	NA	3.1e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.4	0.6	1.6	0.8	-0.8	-1.2	-1.2	0.6	0.0	-0.4	0.6	1.1	0.6	0.3
Bipolar Disorder or Schizophrenia	0.7	1.8	4.3	2.1	-0.8	-0.5	-1.1	1.0	1.2	-1.5	-1.6	2.1	-0.9	1.3
Depressed Affect (Nagel 2018)	0.2	0.5	1.8	0.4	0.9	0.1	0.9	-0.0	0.4	-1.3	-0.3	-0.2	-1.1	0.7
Depression (Nagel 2018)	0.4	0.6	4.2	0.0	0.1	-0.6	-0.0	0.3	-0.1	-1.0	-2.1	0.1	-0.2	0.8
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.1	0.1	1.4	1.8	1.7	0.5	0.8	-1.2	-1.4	0.9	-0.4	1.2
Neuroticism (Nagel 2018)	0.7	1.7	6.4	-1.2	0.3	0.4	-0.1	-2.0	-1.8	0.6	0.0	-1.3	-2.5	-0.8
Schizophrenia (2018)	1.0	2.1	6.1	2.0	-0.3	0.4	-0.4	0.9	1.5	-1.5	-2.5	1.7	-1.6	1.4
Schizophrenia vs Biploar Disorder	1.1	1.4	3.9	1.9	-0.6	1.9	-0.1	-0.3	0.3	-0.8	-1.6	0.6	-2.0	0.4
Worry (Nagel 2018)	1.5	3.1	7.6	-2.4	0.8	0.3	0.5	-2.7	-2.5	1.2	-0.3	-2.3	-1.8	-1.7
Alzheimer’s Disease (in mother)	2.0	2.4	6.2	-1.6	-0.1	-1.0	-0.0	-1.6	-2.1	1.6	2.5	-1.3	-1.7	-1.6
Alzheimer’s Disease (in father)	2.1	2.3	4.9	1.0	1.7	1.1	2.2	1.7	1.4	-1.7	1.6	0.1	-0.1	2.1
Alzheimer’s Disease (including proxy)	0.8	1.2	7.6	-0.7	-0.2	-1.1	-0.1	-0.5	-1.0	0.6	2.8	0.0	-1.5	-0.1
Crohns Disease (2017)	0.3	0.7	1.7	0.9	-0.8	-0.0	-0.8	-0.4	0.2	1.3	0.4	1.0	-1.1	1.1
Irritable Bowel Disease (IBD)	0.3	0.7	1.8	0.2	-1.1	0.6	-1.3	-0.5	-0.1	1.3	0.4	1.1	-0.7	0.6
Ulcerative Colitis (UC)	0.3	0.6	2.1	-0.6	-1.2	0.8	-1.4	-0.3	-0.3	0.9	0.2	0.9	-0.4	0.2
Major Depression (MDD)	1.5	1.9	7.5	0.9	1.3	0.6	1.5	1.2	1.3	-1.0	-2.7	-0.3	-1.3	1.5
Reaction Time	0.3	0.6	2.9	-0.1	0.6	0.5	0.2	-0.2	-0.4	-0.8	-0.5	-1.2	1.7	-0.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.0	0.3	0.7	1.7	0.9	0.5	1.1	-0.9	-1.5	1.1	-0.5	0.9
Breast Cancer	0.8	2.0	4.5	-2.1	1.4	-0.1	1.6	-1.6	-1.8	0.6	-1.0	-1.8	0.7	-1.5
Ovarian Cancer	0.1	0.2	0.8	0.1	-0.2	-0.1	0.1	-0.0	-0.3	0.5	-0.5	-0.7	-0.9	-0.4
Prostate Cancer	0.5	0.7	2.3	-1.0	-0.8	0.5	-0.9	-0.7	-0.8	0.6	0.9	0.4	0.5	-1.5
Age at First Birth	0.7	1.0	2.6	-1.3	-0.8	-0.6	-0.8	-1.1	-1.6	0.7	-0.4	0.5	1.4	-1.1
Bipolar Disorder (2011)	0.7	0.7	3.4	0.7	-1.0	-0.5	-1.8	-0.2	-0.6	0.6	1.1	0.7	-0.2	-0.2
Body Mass Index (BMI) (2010)	0.8	1.1	3.5	-1.4	0.0	1.6	0.0	-0.9	-0.6	0.7	-1.9	-1.0	-0.8	-1.0
Coronary Artery Disease (CAD)	1.2	1.4	4.0	-1.2	-2.0	-0.2	-1.8	-1.4	-0.4	-0.1	0.5	1.6	-0.4	-1.4
Crohns Disease (2012)	0.4	0.6	2.2	0.1	-0.0	1.5	-0.5	-0.3	-0.4	1.4	-0.8	-0.9	0.5	0.4
Mean Putamen Volume	0.5	0.5	1.6	-1.1	0.3	0.7	0.3	0.2	-0.6	-0.1	1.3	0.3	1.2	0.4
Fasting Glucose	1.4	1.6	4.1	1.8	-0.3	-0.3	-0.0	1.4	2.0	-1.7	-0.3	1.1	1.7	1.2
HbA1C	1.5	1.7	3.6	1.2	-1.6	-1.7	-1.9	-0.8	-0.2	0.8	-1.5	1.6	-1.6	-0.4
HDL Cholesterol	0.3	0.5	4.0	-0.2	0.5	2.0	0.1	0.9	-0.1	-0.1	0.0	0.1	-0.2	0.7
LDL Cholesterol	1.7	2.7	7.3	2.4	0.0	-0.8	0.6	2.0	2.7	-1.5	-0.7	1.7	1.8	1.9
Lupus	0.6	0.9	4.2	-2.1	1.6	-0.3	0.9	-0.1	0.1	0.2	-0.0	-1.3	0.8	-0.1
Neuroticism (2016)	0.5	0.8	5.0	-0.5	0.2	0.3	0.1	-0.8	-0.8	0.4	1.2	-0.4	-2.2	-0.1
Primary Biliary Cirrhosis	0.5	0.7	1.5	-1.2	1.1	0.8	1.0	-0.4	-0.6	0.1	-1.1	-0.7	1.2	-0.2
Rheumatoid Arthritis	0.2	0.3	0.9	0.1	-0.8	-1.0	-0.6	-0.7	-0.3	0.4	-0.1	0.7	-0.0	-0.4
Schizophrenia (2014)	1.1	2.4	5.9	2.4	-0.4	1.0	-0.4	1.1	1.9	-1.9	-2.0	1.7	-0.9	1.7
Triglycerides	0.2	0.3	1.1	0.8	-0.9	1.0	-0.4	-0.5	-0.3	0.0	-0.6	0.3	0.2	-0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.6	0.5	0.4	1.3	0.5	0.2	0.4	-0.2	-1.3	0.1	-0.9	0.3
Ulcerative Colitis	0.3	0.4	1.4	-0.6	-0.5	1.2	-0.9	0.1	-0.5	0.9	-0.4	0.6	0.6	0.2
Blood Eosinophil Count	0.9	6.7	19.6	-1.9	-1.9	-0.6	-1.8	-4.3	-4.4	1.9	1.3	0.2	-1.4	-4.2
Blood Platelet Count	0.4	4.9	19.6	-0.6	1.8	1.6	1.3	3.1	1.8	-2.2	1.7	-2.2	4.4	0.9
Blood Red Count	0.9	8.7	21.5	4.0	-0.2	0.1	0.1	4.3	4.6	-2.4	-1.8	3.5	-1.3	4.1
Blood White Count	0.3	2.3	6.1	1.7	-2.5	-0.6	-2.4	-0.8	0.1	-0.3	0.6	2.4	-1.7	-0.2
Heel T-Score	26.1	207.9	600.2	-24.5	10.7	3.0	10.5	-16.7	-15.9	13.8	0.9	-20.2	5.1	-17.2
BMI	0.4	2.5	20.7	-0.8	0.0	1.3	-0.2	-0.1	0.3	0.9	-4.5	0.3	1.9	-0.3
Height	0.9	17.2	47.7	4.1	-6.9	-3.5	-5.7	-3.4	-0.9	0.5	-0.5	5.4	-5.7	-2.3
Waist Hip Ratio (WHR)	0.5	2.2	9.7	1.4	-1.2	0.1	-1.1	-0.1	-0.2	-1.2	2.7	0.8	-3.1	-0.0
Systolic Blood Pressure	0.7	3.6	18.5	1.3	2.2	0.2	2.7	0.1	-0.8	-1.1	-1.7	-1.1	-4.3	1.0
Smoking Status	0.7	1.6	6.7	1.2	-1.1	-0.7	-0.9	0.6	0.5	-0.6	2.6	1.3	-1.6	1.2
Allergy or Eczema	1.1	3.0	8.6	-2.3	2.9	0.5	2.2	0.3	-0.6	1.0	-2.0	-2.6	1.2	-0.1
Cardiovascular Disease	0.8	2.7	8.2	-1.0	2.5	1.6	2.4	1.3	-0.8	-0.2	-2.9	-1.3	-0.4	1.4
Hypothyroidism (self reported)	0.4	0.9	2.2	-0.2	-1.5	-1.0	-1.1	-0.9	-1.1	1.0	-1.0	0.8	0.3	-0.9
Respiratory disease	0.6	1.3	3.3	1.0	0.4	-0.8	0.6	1.7	1.5	-1.5	-0.2	0.5	-0.9	1.8
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.7	1.3	1.3	1.9	1.5	0.7	1.0	-0.3	-0.8	-0.4	-1.8	1.4
Lung FEV1/FVC ratio	1.1	5.8	17.5	0.8	-3.8	-1.3	-4.2	-2.5	-1.6	1.3	-2.4	1.8	1.4	-2.9
Lung FVC	0.2	1.0	7.7	0.2	-1.1	-0.5	-0.6	0.6	0.7	0.1	2.8	0.7	0.8	-0.1
Neuroticism	1.0	2.4	5.4	-1.7	1.7	1.0	1.4	-1.9	-1.9	0.2	-0.1	-2.1	-2.3	-1.0
Chronotype (morning person)	1.0	2.2	6.6	1.3	-1.6	0.8	-0.9	-2.6	-1.3	1.6	-0.8	0.4	-1.8	-2.0
Hair Pigment	0.3	7.9	21.7	1.6	3.0	0.2	3.0	3.8	2.7	-3.2	4.7	-0.5	-0.1	3.6
Tanning	0.4	4.8	14.0	0.6	-3.7	-2.2	-3.6	-1.2	-0.1	0.5	2.0	3.7	0.6	-0.6
Hand grip strength (left)	0.1	0.4	1.5	0.1	-0.5	0.8	-0.2	0.1	-0.1	-0.3	1.1	0.6	-1.2	0.4
Number of treatments/medications taken	0.3	0.6	2.2	-0.1	-0.3	-1.2	-0.5	0.8	0.1	0.1	-1.1	0.5	1.5	0.3
Average weekly spirits intake	0.6	0.7	2.7	0.0	-1.6	-0.3	-1.4	-0.7	-0.6	-0.1	0.2	1.2	0.6	-0.9
Sensitivity / hurt feelings	0.8	1.3	3.5	-0.8	-1.3	-0.3	-1.2	-1.9	-1.5	1.4	-0.0	0.7	-1.1	-1.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.1	-0.4	0.6	-0.4	0.4	0.1	-0.1	-0.8	-0.6	-0.1	-0.6	1.0
Hearing difficulty/problems: Yes	3.7	5.6	18.7	0.5	-4.3	-1.3	-3.6	-2.8	-0.9	1.2	-0.1	3.6	-0.9	-2.0
Relative age of first facial hair	1.1	2.3	7.9	-1.2	2.0	1.6	1.8	0.2	-0.3	-0.8	-2.8	-1.5	1.6	-0.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.2	1.8	0.3	-0.5	0.4	1.3	1.1	-1.0	-1.0	0.5	0.4	1.2
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.9	0.9	-0.5	0.4	-0.2	-0.4	-0.1	-0.4	1.5	1.7	-1.7	0.6
Ever had hysterectomy (womb removed)	2.6	3.0	7.2	2.4	-0.5	0.6	-0.3	2.5	2.7	-1.6	0.8	2.1	-0.9	2.2
Systolic blood pressure, automated reading	0.9	2.6	13.2	2.8	-0.0	-0.6	0.2	1.0	1.0	-0.8	-0.1	1.2	-3.6	1.8
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.1	0.2	1.3	0.1	1.4	0.7	0.7	-0.4	-0.8	-1.2	0.9	0.5
Angina	1.5	1.9	8.3	-0.6	0.9	-0.9	0.1	-0.8	-1.9	1.7	-0.1	-2.9	0.3	-2.0
Medication for hormone replacement therapy	0.3	0.4	2.9	-0.2	-0.3	-0.4	-0.4	-0.4	-0.2	-0.3	1.7	0.0	-0.5	-0.4
Vitamin and mineral supplements	0.5	0.7	2.7	-0.4	-0.1	0.2	0.2	1.3	0.7	-0.3	-1.6	0.1	1.4	0.7
Supplements: Zinc	0.9	1.0	2.3	-0.3	-0.8	-1.5	-0.8	-1.0	-1.4	1.2	0.4	-0.2	1.3	-1.2
Medication: Co-codamol	0.3	0.3	1.0	-0.8	0.7	0.3	0.6	-0.2	-0.6	0.0	-0.3	-1.0	-0.5	-0.3
Medication: Metformin	1.1	1.5	3.4	1.8	1.4	0.5	1.1	1.2	1.6	-1.0	0.0	-0.5	-1.5	1.5
Diabetes (father)	0.3	0.4	1.7	-1.1	-0.4	-0.2	0.1	-0.5	-0.0	0.1	-1.3	0.3	0.6	-0.9
Diabetes (mother)	1.1	1.4	4.7	2.2	-0.2	-1.4	0.4	0.9	1.0	-0.4	-1.5	0.5	-1.6	1.0
Severe depression (siblings)	0.7	0.8	2.2	-0.6	-0.8	-1.1	-1.0	-0.7	-1.2	1.0	-0.2	0.3	1.5	-0.8
Pack years adult smoking proportion	1.8	2.7	7.0	2.2	-2.1	-2.6	-1.7	0.5	1.0	0.3	-0.2	1.9	-2.0	1.2
Impedance of leg (right)	1.2	5.9	14.1	3.1	-3.4	-1.8	-2.5	-0.1	1.7	-1.3	3.8	3.7	-0.9	0.7
Leg fat-free mass (left)	0.5	2.5	19.5	-0.3	-1.0	0.3	-1.1	-0.9	-1.0	1.3	-4.4	0.3	-0.6	-1.0
Trunk fat percentage	1.6	6.3	17.6	3.1	-3.2	-1.2	-3.2	1.1	2.5	-0.0	-3.3	4.2	0.2	1.1
Hand grip strength (right)	0.1	0.3	2.2	-0.1	-0.1	0.4	0.2	-0.3	-0.4	0.0	0.7	-0.1	-1.5	0.1
Townsend deprivation index at recruitment	1.0	1.4	5.5	0.2	2.0	-0.2	2.3	0.1	-0.4	-1.2	-0.8	-0.6	-1.4	1.0
Current tobacco smoking	1.7	2.7	6.0	1.9	-1.6	-1.6	-1.4	1.0	1.3	-1.1	1.6	1.9	-2.4	1.8
Average weekly fortified wine intake	0.7	0.9	3.3	0.6	-0.5	-0.4	-0.2	0.9	1.3	-0.9	-0.7	1.8	0.8	0.8
Maternal smoking around birth	0.7	1.0	3.1	1.7	0.8	0.9	1.1	-1.0	-0.6	-0.9	0.4	-0.6	-1.7	0.1
Fed-up feelings	0.3	0.5	2.7	0.4	0.1	-1.1	0.0	0.4	0.2	-0.5	-0.1	0.1	-1.6	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	2.7	0.3	-0.3	-0.7	-0.3	0.4	0.5	-1.0	-1.6	1.0	0.4	0.6
Relative age voice broke	1.5	2.3	4.5	0.7	2.1	0.2	2.1	1.5	1.2	-2.1	-2.1	-0.7	1.1	1.4
Taking other prescription medications	0.7	1.1	3.1	1.2	-0.3	-0.6	-0.4	1.1	0.6	-0.9	-1.8	1.1	1.4	0.8
Age when periods started (menarche)	0.2	0.6	1.7	-0.2	0.9	-0.8	1.0	0.4	0.9	-1.3	0.8	0.0	0.2	0.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.0	0.9	1.0	0.4	1.4	0.4	0.6	-0.6	-0.4	-0.3	-1.3	0.9
Heel bone mineral density (BMD) T-score, automated (left)	12.7	28.9	84.3	-9.2	3.8	1.4	3.6	-5.8	-5.8	5.7	0.3	-7.7	2.3	-6.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.7	-0.4	0.6	0.7	0.5	1.0	0.7	-0.6	0.1	-0.2	1.3	0.5
Qualifications: CSEs or equivalent	0.4	0.6	1.6	-0.6	0.0	0.8	-0.1	-1.1	-1.2	1.1	0.0	-0.7	-0.5	-0.4
Serious illness, injury or assault to yourself	3.8	4.7	9.0	2.9	-1.0	-1.9	-1.0	3.0	2.3	-2.8	-1.7	2.0	2.1	2.0
High blood pressure	0.9	2.6	8.0	1.4	1.7	0.9	1.7	2.8	1.1	-0.8	-1.9	-0.1	-0.7	2.4
Hayfever, allergic rhinitis or eczema	1.0	2.3	6.4	-1.8	2.5	-0.1	2.0	0.1	-0.2	0.5	-2.2	-2.0	1.4	0.1
Multivitamins +/- minerals	0.3	0.3	1.1	0.6	0.8	0.6	0.5	-0.7	-0.0	-0.4	1.1	-0.1	-0.5	0.2
Stomach or abdominal pain in last month	0.3	0.4	2.0	-0.7	-0.2	-1.4	0.2	-1.0	-0.6	-0.6	-0.1	0.6	0.1	-0.3
Supplements: Glucosamine	0.6	0.8	3.8	-0.1	-0.2	-1.1	-0.2	0.1	0.5	-0.5	1.4	1.2	1.9	-0.2
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	2.3	0.1	1.1	1.1	1.5	0.6	1.1	-0.4	-0.8	-0.5	-0.1	1.5
Medication: Atenolol	0.5	0.6	2.4	-1.6	0.1	1.1	-0.1	-0.4	-0.7	1.2	0.2	-0.9	0.1	-0.5
Medication: Levothyroxine sodium	0.2	0.4	1.0	0.1	-1.0	-0.0	-0.4	-0.8	-1.0	0.5	-0.3	0.7	0.3	-0.7
Sitting height	0.7	4.9	14.2	0.3	-3.8	-2.3	-3.2	-2.0	-0.8	1.1	-0.4	3.0	-2.6	-1.5
Chronic bronchitis/emphysema (father)	0.6	0.7	1.8	0.5	0.5	0.8	0.6	0.8	1.3	-0.8	-1.3	0.4	0.3	1.3
High blood pressure (mother)	1.0	1.3	4.4	-1.1	1.5	-0.5	1.2	-0.1	-0.4	0.2	-2.1	-2.1	-0.5	-0.4
Body mass index (BMI)	0.4	1.9	16.5	0.3	-0.6	-0.1	-1.0	0.3	0.3	1.2	-4.1	0.6	0.9	0.0
Impedance of leg (left)	1.1	5.3	16.6	2.6	-3.1	-2.0	-2.2	-0.4	1.4	-1.4	4.1	3.4	-0.9	0.3
Leg predicted mass (left)	0.4	2.4	19.4	-0.2	-1.0	0.3	-1.1	-0.8	-1.0	1.2	-4.4	0.3	-0.6	-0.9
Trunk fat mass	1.2	5.0	13.2	2.4	-3.1	-0.9	-3.0	0.3	1.5	0.5	-3.6	3.6	-0.3	0.4
Waist circumference	0.7	2.7	7.7	1.3	-2.5	-0.4	-2.7	-0.1	0.4	0.8	-2.8	2.3	-0.8	-0.1
Number of incorrect matches in round	3.8	6.3	23.9	-0.8	-3.6	-1.1	-4.9	-0.5	-2.4	3.3	3.3	0.6	-0.5	-1.6
Past tobacco smoking	0.5	0.9	8.2	0.1	0.0	-0.5	-0.1	0.5	0.9	0.1	-2.9	0.1	-0.5	0.5
Alcohol usually taken with meals	0.2	0.4	1.5	-0.1	0.5	0.2	0.2	0.4	1.0	-0.9	0.3	0.3	1.2	0.5
Nervous feelings	0.4	0.7	3.2	-0.2	0.9	0.5	0.9	-0.0	0.1	-0.7	1.3	-0.3	-1.8	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.5	-0.0	0.9	0.5	1.0	-0.4	-0.1	-1.1	-1.4	-0.9	-1.9	0.6
Hearing difficulty/problems with background noise	1.7	2.7	6.7	-0.1	-2.6	-0.8	-2.4	-2.2	-1.2	1.5	-0.6	1.5	-1.1	-1.9
Hair/balding pattern: Pattern 2	3.2	4.0	11.5	0.6	2.6	1.4	2.2	3.4	1.5	-1.8	0.6	-1.2	1.9	2.7
Had menopause	0.4	0.5	2.0	0.2	0.1	0.6	-0.2	0.3	0.7	-0.8	1.4	1.0	-0.6	0.8
Had other major operations	1.5	1.9	7.0	1.9	-2.1	-1.0	-1.8	0.3	0.6	-0.1	-0.1	2.6	-0.9	0.2
Forced vital capacity (FVC)	0.6	2.4	7.7	1.0	-2.8	-2.2	-1.8	-1.0	-0.2	-0.5	0.4	2.6	-1.0	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	13.6	31.2	87.0	-9.3	3.2	1.2	3.0	-6.9	-6.1	6.3	0.6	-7.9	1.3	-6.7
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	3.5	-0.6	1.5	-0.5	1.5	-0.3	-1.4	1.0	-1.9	-1.6	0.4	-0.2
Qualifications: None of the above	0.6	1.3	4.6	1.4	-1.3	-0.2	-1.1	0.6	0.0	-0.8	1.3	1.3	-2.1	0.6
Financial difficulties in last 2 years	0.6	0.8	1.7	1.2	0.9	-0.2	1.1	0.6	0.6	-0.8	-1.3	-0.7	-0.7	1.3
Mouth/teeth dental problems	0.5	0.7	4.8	-1.0	0.5	2.2	1.0	0.1	0.8	-0.1	0.1	-0.6	0.0	-0.1
Heart attack	0.4	0.6	1.8	0.3	0.5	-1.3	0.3	0.7	0.6	-0.5	1.2	-0.9	0.6	-0.5
Allergy	0.5	1.1	3.3	1.0	-1.8	0.7	-1.4	-0.6	-0.4	0.5	1.6	0.9	-0.7	-0.7
Pain all over the body in last month	0.4	0.4	1.1	0.2	0.8	-0.7	0.8	0.1	-0.3	-0.6	1.0	-0.8	-0.5	-0.2
Diabetes (self-reported)	0.8	1.2	3.0	1.7	1.3	0.3	1.5	1.1	1.4	-0.6	0.6	-0.1	-1.1	1.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.3	-0.1	-0.3	-0.5	-0.3	0.3	0.2	-0.5	0.4	1.2	0.8	0.3
Medication: Ramipril	1.4	1.8	4.9	2.2	-0.4	-0.3	-0.2	1.8	2.1	-1.4	-0.2	1.8	0.0	1.5
Medication: Simvastatin	0.8	1.2	3.0	1.3	-0.4	-1.4	-0.1	1.7	1.4	-0.7	0.6	0.6	-0.7	1.6
Fluid intelligence score	0.2	0.5	2.2	0.1	0.8	1.5	0.9	0.2	0.2	-0.5	0.1	0.3	-0.9	0.7
Illnesses of siblings	1.1	1.5	4.7	-0.1	-2.0	0.6	-1.3	-2.2	-1.0	0.2	0.0	0.6	0.0	-2.1
Neuroticism score	0.6	1.3	2.5	-1.3	1.0	1.4	0.8	-1.2	-1.4	0.0	-0.5	-1.4	-1.6	-0.5
Weight	0.7	3.3	21.0	0.8	-2.1	-0.5	-2.1	-0.8	-0.1	1.3	-4.6	1.7	-0.5	-0.7
Impedance of arm (right)	0.6	2.8	8.8	2.5	-2.2	-0.5	-2.0	0.7	1.6	-0.8	1.3	3.0	-0.3	1.0
Arm fat percentage (right)	1.0	4.1	15.4	2.3	-1.9	-0.0	-2.3	1.3	1.8	0.6	-3.9	2.8	1.0	1.1
Trunk fat-free mass	0.3	1.9	11.4	-0.3	-0.6	0.4	-0.5	-1.4	-1.4	1.2	-3.4	-0.1	-1.4	-1.2
Hip circumference	0.9	4.0	23.1	1.0	-2.3	-0.6	-2.4	0.0	0.8	1.2	-4.8	2.5	0.5	0.0
Time employed in main current job	0.4	0.5	4.0	0.7	-0.4	2.0	-0.5	0.2	0.0	-0.2	-0.1	0.3	-0.5	-0.0
Alcohol intake versus 10 years previously	0.8	1.2	4.1	2.0	0.1	0.3	0.0	0.7	1.3	-0.5	-1.4	0.8	-1.4	1.3
Father’s age at death	0.7	1.0	3.6	1.3	-0.0	-0.1	0.3	0.9	1.9	-1.0	-1.4	0.7	0.5	1.0
Worrier / anxious feelings	1.7	3.2	8.9	-1.4	-0.2	0.9	-0.5	-2.5	-3.0	2.3	-1.6	-1.6	-1.6	-2.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	4.5	1.2	0.4	-0.5	0.4	0.0	0.5	-2.1	-1.7	0.7	-0.5	0.5
Falls in the last year	0.7	1.0	2.7	1.4	-1.2	-1.6	-0.6	-0.8	1.0	-0.4	-1.1	0.8	-0.4	-0.5
Hair/balding pattern: Pattern 3	2.4	3.5	9.7	-3.1	0.6	-0.2	0.5	-2.4	-2.4	1.8	-1.6	-2.1	-0.1	-2.6
Number of live births	2.0	2.9	7.7	1.0	1.9	0.5	2.1	1.9	1.4	-2.8	2.0	-0.5	-1.0	2.0
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	13.8	1.1	-3.7	-2.1	-3.0	-1.5	-0.6	0.0	-0.6	3.0	-0.1	-1.3
Pulse rate	0.6	0.9	2.5	0.1	-1.6	-0.0	-1.4	-0.8	-1.0	0.5	-1.1	0.2	0.8	-1.5
Happiness	0.4	0.5	0.9	0.7	0.8	-0.2	0.9	0.6	0.4	0.0	1.0	-0.9	0.0	0.9
Noisy workplace	0.5	0.6	1.7	0.5	0.1	-1.1	-0.1	0.9	0.4	0.6	-0.3	0.7	-1.2	1.3
Qualifications: A levels/AS levels or equivalent	0.5	1.0	7.1	-0.4	-0.2	0.1	-0.1	-0.1	0.1	0.1	-2.7	0.3	1.8	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	3.2	0.9	-0.4	-0.5	-0.5	0.3	0.5	-0.8	-1.8	0.6	0.3	0.3
Mouth/teeth dental problems: Dentures	1.3	2.1	5.0	2.1	1.1	-0.2	1.0	2.2	1.9	-2.0	-0.3	0.4	-0.2	2.0
Asthma	0.9	1.8	4.8	1.1	0.7	-0.0	1.1	1.8	1.7	-2.1	-0.9	0.7	-0.6	2.2
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.1	0.0	1.6	0.6	1.7	0.5	0.7	-1.5	-1.8	-1.0	1.7	0.7
Medication: Cholesterol lowering	0.6	0.9	3.6	1.1	0.8	-0.2	0.6	1.9	0.8	-0.1	0.5	-0.2	0.4	1.5
Depression (self-reported)	1.9	2.3	8.4	2.0	-1.1	-2.9	-1.3	1.4	1.2	-1.2	-0.7	1.5	-0.1	1.4
Medication: Lansoprazole	1.0	1.1	3.5	0.6	0.6	1.0	0.9	1.9	1.4	-1.2	-0.1	0.4	-0.1	1.7
Prospective memory result	0.8	1.0	3.3	0.3	1.3	0.8	0.7	1.2	-0.9	0.1	-1.5	-1.8	0.6	0.4
Lung cancer (father)	0.2	0.3	1.1	0.0	-0.2	-0.3	-0.1	0.3	0.5	0.4	0.5	0.4	-1.1	1.0
Illnesses of mother	0.6	0.8	1.4	0.8	-0.8	1.0	-1.0	1.0	1.2	0.1	-0.3	1.0	1.1	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.8	15.7	1.2	-4.0	-1.6	-3.2	-2.4	-0.9	0.4	-1.4	3.2	-0.3	-2.1
Pulse wave Arterial Stiffness index	0.4	0.4	1.6	-0.1	0.6	0.8	0.4	0.6	-0.6	0.9	-0.1	-1.3	-0.6	0.3
Impedance of arm (left)	0.7	3.1	8.5	2.4	-2.2	-0.5	-2.0	1.0	2.0	-1.3	1.6	2.9	-0.1	1.1
Arm fat mass (right)	0.9	3.5	18.6	1.6	-2.1	-0.2	-2.3	0.4	0.9	1.0	-4.3	2.4	0.4	0.3
Trunk predicted mass	0.3	1.8	11.2	-0.2	-0.6	0.3	-0.5	-1.4	-1.3	1.3	-3.3	-0.1	-1.3	-1.2
Standing height	0.5	4.5	11.1	1.4	-3.3	-0.9	-2.6	-2.3	-0.9	0.1	-1.6	2.6	-3.3	-1.6
Length of working week for main job	1.1	1.2	3.1	-1.0	1.1	1.5	0.9	0.6	0.8	-0.3	-1.8	-1.7	0.7	-0.2
Exposure to tobacco smoke at home	0.7	0.8	4.0	0.1	0.3	-1.3	0.5	0.6	0.6	-0.2	-2.0	-0.3	1.4	0.3
Breastfed as a baby	0.9	1.1	3.1	1.6	-0.3	-0.5	-0.2	1.8	1.7	-1.0	0.3	0.7	0.9	0.9
Tense / ‘highly strung’	1.9	3.1	9.1	-3.0	1.6	1.3	1.3	-2.4	-2.3	0.9	-0.0	-2.3	-1.0	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	5.5	-1.0	0.8	-1.3	0.4	-0.5	-0.6	1.8	-2.3	-1.5	0.8	-0.3
Hair/balding pattern: Pattern 4	0.9	2.2	7.6	-1.7	-0.8	1.0	-0.8	-2.7	-1.3	1.1	1.3	-0.6	-0.3	-2.6
Birth weight of first child	3.2	5.8	12.5	-0.2	3.4	2.5	3.0	2.5	1.7	-1.1	-3.5	-1.8	2.9	1.7
Peak expiratory flow (PEF)	0.6	1.3	4.7	1.2	-1.5	-1.0	-1.0	0.5	0.8	-1.4	-0.8	2.2	0.6	0.4
Pulse wave reflection index	1.2	1.4	6.1	-0.3	1.7	0.9	1.8	-0.0	-0.7	-0.3	1.1	-2.5	-1.1	-0.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.2	-0.2	1.0	1.5	1.0	-0.6	-0.2	0.7	-1.4	-0.6	-0.7	-0.0
Loud music exposure frequency	0.5	0.6	1.6	0.2	-0.9	0.6	-0.7	-1.3	-0.8	-0.1	-0.6	0.6	0.8	-0.9
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	7.3	-1.8	1.2	-1.1	0.9	0.4	0.4	-0.4	-2.4	-0.7	2.7	0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.7	-0.4	-0.7	-0.9	-1.2	-0.0	-0.1	-0.2	0.2	1.3	1.0	0.2
Blood clot in the leg (DVT)	0.9	1.1	4.0	-2.0	-0.1	0.5	-0.1	-1.3	-1.0	0.2	0.1	-0.9	1.0	-2.0
Medication: Paracetamol	1.6	2.7	6.2	-2.2	1.5	2.5	1.5	-1.8	-1.6	0.5	-0.8	-2.1	-0.7	-1.6
Headache pain in last month	1.3	2.2	8.9	-1.2	2.1	0.9	1.8	-0.0	-0.5	-0.9	-3.0	-2.1	-0.2	-0.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	3.8	-1.0	-0.3	0.8	-0.3	-1.9	-0.6	-0.2	-0.0	-0.4	-0.8	-1.3
Glaucoma (self-reported)	2.0	2.4	6.1	1.8	-1.3	-0.9	-1.4	2.0	2.5	-0.9	0.7	2.1	0.9	1.3
Gout (self-reported)	0.2	0.3	1.3	-0.2	-0.0	-0.6	0.2	-0.0	-0.2	-1.1	0.0	-0.1	1.1	-0.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.7	-0.5	-1.9	-1.1	-1.6	-1.4	-1.5	1.5	0.4	1.2	0.6	-1.3
Medication: Amlodipine	0.9	1.2	8.3	0.5	0.8	0.1	0.7	1.4	0.5	0.3	-2.9	-0.1	-0.2	1.2
Medication: Ventolin 100micrograms inhaler	1.5	1.9	5.4	2.3	-0.4	-0.9	0.1	1.2	1.4	-2.0	-0.0	2.1	-0.1	1.7
Birth weight	0.5	1.1	2.7	0.2	1.5	0.9	1.3	0.9	0.1	-0.1	-1.5	-0.7	-1.6	1.1
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.2	-0.3	1.0	1.0	1.0	-0.8	0.4	-0.2	-0.1	-1.1	0.7	-0.5
High blood pressure (siblings)	2.6	3.8	10.6	1.1	2.4	-0.5	2.3	3.2	2.4	-1.4	-0.7	-0.0	0.6	3.1
Forced vital capacity (FVC), Best measure	0.8	3.0	9.2	1.3	-3.0	-1.8	-2.1	-1.9	-0.4	-0.3	-0.2	2.8	-1.3	-1.3
Body fat percentage	1.5	5.7	15.2	2.8	-3.4	-1.2	-3.3	0.8	2.1	0.3	-3.3	3.9	0.5	0.7
Leg fat percentage (right)	1.2	4.3	11.4	2.5	-3.2	-0.8	-3.1	0.6	1.8	0.5	-2.1	3.4	0.2	0.7
Arm fat-free mass (right)	0.4	1.9	9.9	-0.3	-1.3	-0.3	-0.9	-1.7	-1.1	0.9	-3.1	0.4	-1.2	-1.5
Exposure to tobacco smoke outside home	0.8	1.1	3.7	1.2	0.1	-0.4	0.4	0.6	1.9	-1.4	-1.5	0.9	0.1	1.2
Comparative body size at age 10	1.5	4.1	15.1	-3.9	1.0	0.9	0.6	-1.7	-2.4	2.1	0.9	-1.8	2.6	-1.8
Number of full brothers	0.3	0.4	2.2	-0.3	-0.1	1.2	-0.2	-0.0	0.1	-0.4	-0.5	-0.1	-1.5	0.5
Worry too long after embarrassment	0.6	1.0	3.1	0.9	-0.5	1.8	-0.5	1.0	0.6	-0.8	-0.1	1.1	-1.0	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	5.4	-0.7	1.8	-1.1	1.0	0.2	-1.0	0.3	-1.0	-2.3	0.2	0.5
Wheeze or whistling in the chest in last year	1.0	1.8	3.9	1.6	0.1	0.3	0.4	0.9	1.5	-2.0	-1.9	1.6	-0.2	1.9
Number of children fathered	0.6	0.7	2.0	-0.0	-0.9	-0.6	-1.1	-0.7	-0.7	0.6	-1.1	-0.1	-0.6	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	3.1	1.2	-1.4	-0.8	-1.4	-0.6	0.2	-0.0	-0.4	1.4	-1.8	0.0
Age at first live birth	0.7	1.2	8.0	-0.8	-0.4	0.3	-0.4	1.2	0.7	0.2	-0.2	1.2	2.8	0.5
Pulse wave peak to peak time	0.4	0.5	2.1	0.2	-0.8	-0.7	-0.6	-0.7	0.7	-0.9	0.2	1.5	0.2	-0.3
Health satisfaction	0.2	0.3	1.1	0.5	0.1	-0.8	0.4	0.4	0.7	-1.1	-0.2	0.1	0.0	0.7
Shortness of breath walking on level ground	0.5	0.6	2.3	-0.2	0.2	-1.5	0.4	-1.1	-0.5	0.4	-0.8	-0.5	-1.0	-0.4
Qualifications: College or University degree	0.3	0.8	3.0	0.9	-1.0	-1.7	-1.0	-0.8	-0.1	0.4	-0.2	1.2	-0.1	-0.8
Eye problems/disorders: None of the above	0.8	0.9	2.3	-1.0	-0.6	0.4	-0.5	-1.4	-1.5	1.3	-0.6	-0.4	-0.2	-1.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.0	-0.2	-0.2	-0.8	-0.2	-0.5	-1.0	0.7	-0.8	-0.4	-0.9	-0.1
Emphysema/chronic bronchitis	0.3	0.4	1.9	0.1	0.2	-0.1	0.4	0.4	0.1	-0.5	1.4	-0.2	-1.0	0.7
Medication for pain relief, constipation, heartburn	1.0	1.8	4.0	1.2	-1.7	-2.0	-1.7	0.4	0.7	-0.0	1.9	1.9	-0.6	0.6
Neck or shoulder pain in last month	0.4	0.5	1.6	-0.3	1.2	0.4	1.2	0.3	0.3	-0.0	-1.0	-1.0	0.3	0.2
Medication: Blood pressure	0.5	0.8	2.2	1.1	-0.7	-1.3	-0.6	1.5	0.5	0.4	0.6	1.2	0.4	0.9
Angina (self-reported)	1.5	1.9	7.5	-0.8	0.7	-0.8	-0.1	-0.8	-1.8	1.8	-0.4	-2.7	0.6	-2.0
Migraine (self-reported)	0.5	0.7	1.8	-0.3	-1.0	-0.6	-1.2	-0.8	-1.3	1.0	0.5	-0.1	-0.9	-0.4
Medication: Ibuprofen	0.9	1.1	4.9	0.1	1.0	0.2	1.0	0.6	0.9	-1.2	-1.2	0.0	2.2	0.8
Medication: Allopurinol	0.4	0.6	1.4	-0.5	0.4	0.5	0.8	-0.6	-0.3	-1.2	-1.1	-0.6	0.9	-0.9
Medication: Omeprazole	0.2	0.3	1.0	-0.5	0.5	1.0	0.6	0.4	0.0	0.5	-0.2	-0.5	-0.6	0.6
Medication: Seretide 50 evohaler	0.8	0.9	5.2	0.0	-0.8	-2.3	-0.6	-1.0	-0.6	-1.2	0.2	0.1	-0.7	-0.9
Mean time to correctly identify matches	0.4	0.7	2.5	0.7	0.9	0.5	0.5	1.1	0.8	-1.0	0.3	-0.5	1.6	0.8
Heart disease (mother)	0.5	0.7	2.1	-0.7	-0.2	-0.3	-0.3	-1.5	-1.4	0.5	-0.4	-0.2	-0.8	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.9	0.9	0.6	0.7	0.7	1.4	-0.2	-0.6	0.9	0.0	0.4	1.4
Whole body fat mass	1.1	4.8	13.1	2.2	-3.2	-1.2	-3.1	-0.1	1.3	0.7	-3.6	3.3	-0.1	-0.0
Leg fat mass (right)	1.0	3.9	10.3	1.9	-3.2	-0.7	-3.0	-0.4	1.0	0.8	-3.0	2.9	-0.1	-0.2
Arm predicted mass (right)	0.3	1.6	8.6	-0.3	-1.1	-0.2	-0.8	-1.5	-1.0	0.8	-2.9	0.4	-1.2	-1.2
Pulse rate, automated reading	0.8	2.6	5.2	1.7	-2.1	0.3	-1.8	2.0	1.9	-0.7	-0.7	2.3	1.9	0.6
Alcohol intake frequency.	0.8	1.9	4.0	1.6	1.5	-0.3	1.4	1.2	2.0	-1.9	-1.3	-0.2	-0.1	1.7
Comparative height size at age 10	1.1	6.2	14.7	0.3	-3.8	-1.6	-3.4	-3.4	-2.6	2.4	-0.4	1.5	-2.5	-2.7
Number of full sisters	1.4	1.7	5.7	-0.4	2.4	-0.0	2.0	0.6	0.1	0.3	1.7	-2.1	-0.3	0.9
Suffer from ‘nerves’	0.5	0.8	2.8	-1.7	0.5	1.2	0.3	-1.3	-0.6	-0.1	-0.2	-1.1	-0.2	-0.7
Overall health rating	0.4	0.8	2.4	0.8	0.8	-1.5	1.0	0.2	-0.4	0.0	-1.5	-1.0	0.2	0.4
Chest pain or discomfort	1.1	1.7	5.3	-1.3	1.5	-0.2	1.4	-0.1	-0.0	-0.3	-2.3	-1.8	1.8	-0.6
Had major operations	2.0	2.4	8.9	0.4	-1.9	-3.0	-2.2	-1.3	-1.1	1.3	0.8	0.3	-0.2	-1.7
Age at last live birth	0.4	0.5	3.3	-1.3	0.4	0.3	0.6	0.2	-0.1	-0.2	-0.1	0.1	1.8	-0.1
Family relationship satisfaction	0.5	0.6	1.8	1.0	0.3	0.6	0.6	0.7	0.9	-0.4	0.5	0.8	-0.3	1.4
Leg pain on walking	1.9	2.4	11.6	1.0	1.0	-0.2	0.6	1.6	1.8	-1.2	-3.4	0.7	0.7	1.9
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	5.4	-0.9	-0.3	-0.6	-0.1	-0.3	0.4	0.3	-0.6	0.5	2.3	-0.6
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.9	-1.4	0.1	-1.7	-0.2	-0.4	-0.5	0.4	-0.0	-0.7	1.3	-1.1
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	3.4	-1.8	-0.6	1.2	-0.3	-1.7	-1.5	1.4	1.9	-0.0	-1.6	-1.5
Medication: Aspirin	0.3	0.4	1.2	-0.8	0.6	-0.3	0.4	0.6	-0.2	0.2	0.6	-1.1	0.9	-0.4
Supplements: Vitamin C	2.0	2.4	5.2	-1.4	-1.3	-1.5	-1.6	-2.1	-1.4	2.0	1.4	-0.4	-0.5	-2.3
Knee pain experienced in last month	0.4	0.6	2.0	0.3	-0.6	-1.3	-0.4	0.1	1.0	0.5	-1.4	0.8	-0.7	0.3
Hypertension (Self-reported)	0.9	2.4	6.1	0.7	2.1	1.4	2.0	2.5	0.7	-0.5	-1.8	-0.5	-0.7	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.7	1.5	-0.2	0.6	0.3	0.8	1.6	-1.3	-0.0	1.0	-0.7	1.0
Illnesses of father: Heart disease	0.4	0.5	2.2	0.0	0.3	-0.7	0.1	0.5	1.3	-1.5	0.5	0.7	0.0	0.6
Illnesses of siblings: Diabetes	0.3	0.3	1.0	0.4	0.4	0.6	0.2	0.6	0.9	0.1	-0.6	0.4	0.1	1.0
Smoking status: Previous	0.7	1.1	2.8	-1.1	0.2	0.8	0.2	-1.1	-1.5	0.8	1.7	-0.8	0.8	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.9	-0.4	-1.6	-1.1	-1.3	-2.2	-1.1	1.3	-0.4	0.5	-1.7	-1.6
Whole body fat-free mass	0.4	2.4	15.8	-0.3	-1.0	0.3	-0.9	-1.4	-1.4	1.3	-4.0	0.2	-1.2	-1.4
Leg fat-free mass (right)	0.5	2.5	19.9	-0.6	-0.6	0.5	-0.7	-1.0	-1.2	1.2	-4.5	-0.2	-0.6	-1.2
Arm fat percentage (left)	1.0	3.9	13.1	2.1	-2.1	-0.3	-2.4	1.2	1.8	0.4	-3.6	2.8	1.1	1.0
Average weekly red wine intake	1.3	1.9	4.4	-1.7	0.7	0.9	0.5	-1.8	-1.7	1.0	-1.0	-2.1	-0.0	-2.0
Handedness (chirality/laterality): Left-handed	0.8	1.0	5.7	0.9	0.2	0.2	0.4	0.8	0.9	-0.7	-2.4	0.6	1.3	0.3
Mood swings	0.1	0.3	1.0	-0.5	-0.1	-0.4	-0.2	-1.0	-0.4	0.5	0.6	0.0	-0.8	-0.1
Loneliness, isolation	1.0	1.3	3.3	-0.0	1.7	0.5	1.7	1.0	0.0	-1.1	-1.8	-0.7	1.7	0.6
Long-standing illness, disability or infirmity	1.2	1.8	4.8	0.1	2.0	-0.8	2.2	0.5	1.3	-1.4	-2.1	-1.0	-0.4	1.0
Ever had bowel cancer screening	0.5	0.6	4.1	-0.5	0.4	-2.0	0.3	-0.4	-0.5	0.8	-0.3	-0.9	0.4	-0.6
Diabetes diagnosed by doctor	1.6	2.7	5.4	2.0	2.1	0.9	2.3	2.0	1.9	-1.3	0.6	-0.4	-1.0	2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.9	-0.2	0.9	-0.7	0.7	0.5	0.1	-0.7	1.0	-0.5	-1.4	0.4
Friendships satisfaction	1.0	1.2	4.2	-0.8	-1.2	-0.4	-1.4	-0.9	-1.5	2.0	-0.6	0.4	-0.4	-1.2
Qualifications: nursing, teaching	1.5	2.3	12.7	-1.2	0.5	1.8	0.4	-0.1	0.3	-0.1	-3.6	-0.6	2.6	-0.6
Commuting to job workplace: Walk	0.4	0.4	2.0	0.4	0.3	0.4	0.9	-0.1	-0.0	0.1	-1.4	-0.3	0.9	0.2
Eye problems/disorders: Cataract	0.3	0.3	1.1	-0.0	1.1	1.0	0.6	0.3	0.2	0.1	-0.3	-0.5	0.7	0.2
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	7.0	0.0	-0.4	-2.6	-0.8	-1.2	-2.1	1.6	-1.1	-0.7	0.7	-1.3
Medication for cholesterol	0.5	0.8	2.8	1.7	-1.1	-0.5	-1.2	-0.2	0.9	0.3	0.5	1.4	0.1	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.6	0.3	0.4	-0.2	0.6	-0.2	0.2	0.4	0.3	-0.8	0.2	-0.1
Back pain experienced in last month	0.4	0.6	2.8	-0.3	0.3	-0.4	0.4	-1.0	-0.1	0.8	-1.1	-0.0	-1.7	0.0
Mineral and other dietary supplements	1.5	2.0	4.0	1.7	-1.2	0.6	-0.9	1.3	1.4	-1.0	-1.5	2.0	-1.4	1.9
Breast cancer (self-reported)	0.3	0.3	1.1	0.7	1.0	0.7	0.6	1.1	0.1	0.2	0.1	-0.6	-0.1	0.2
Asthma (self-reported)	0.8	1.6	4.3	1.2	0.5	0.1	0.9	1.6	1.4	-2.0	-0.9	0.8	-0.7	2.1
Osteoporosis (self-reported)	2.9	3.6	11.2	1.7	0.7	1.3	0.9	3.0	2.3	-2.0	0.8	1.3	1.3	3.4
Osteoarthritis (self-reported)	0.5	0.7	2.0	0.2	-1.0	-1.4	-0.9	-0.4	0.2	0.1	1.3	1.2	-0.2	-0.3
Medication: Aspirin	0.3	0.4	1.2	-0.7	-0.1	-1.1	-0.4	0.2	-0.3	0.6	0.6	-0.6	1.0	-0.8
Medication: Gliclazide	0.5	0.6	2.4	1.6	-0.5	-0.5	-0.7	0.1	0.8	0.0	-0.3	0.5	-1.5	0.1
Illnesses of father: None of the above (group 1)	0.3	0.4	1.1	-0.0	-0.5	-0.2	-0.5	-0.4	-1.1	1.0	0.3	-0.5	-0.1	-0.8
Smoking status: Current	1.7	2.6	6.5	2.0	-1.3	-1.4	-1.1	1.0	1.2	-1.1	1.9	1.8	-2.5	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	5.1	1.1	-1.9	-0.6	-1.5	-0.0	1.2	-1.1	-0.7	2.3	1.3	-0.6
Whole body water mass	0.4	2.3	16.1	-0.3	-0.9	0.2	-0.8	-1.3	-1.3	1.4	-4.0	0.0	-1.2	-1.2
Leg predicted mass (right)	0.4	2.4	19.8	-0.6	-0.5	0.5	-0.6	-0.9	-1.1	1.2	-4.5	-0.2	-0.6	-1.1
Arm fat mass (left)	0.8	3.5	18.4	1.6	-2.1	-0.5	-2.3	0.2	0.9	1.0	-4.3	2.2	0.2	0.1
Number of self-reported non-cancer illnesses	0.6	1.0	2.5	0.9	-0.1	0.0	0.3	1.6	1.1	-0.7	-1.3	1.0	1.0	1.6
Average weekly champagne plus white wine intake	0.6	0.9	2.6	-0.1	-1.1	0.2	-0.8	-1.6	-1.6	0.5	-0.4	0.3	-0.1	-1.4
Miserableness	1.4	2.4	6.7	0.5	2.2	1.9	2.4	0.5	1.2	-2.6	-0.1	-1.0	-1.0	1.4
Guilty feelings	1.1	1.6	4.4	-1.5	1.1	0.7	1.0	-1.3	-1.9	0.6	-1.0	-2.1	-0.7	-1.1
Wears glasses or contact lenses	0.6	0.7	3.8	1.2	-0.4	0.6	-0.3	0.1	0.3	-1.0	2.0	1.0	-0.3	-0.1
Ever taken oral contraceptive pill	2.9	3.2	7.5	0.2	-2.7	-1.7	-2.6	-1.6	-2.6	1.9	0.1	1.1	-0.8	-1.7
Hearing aid user	7.5	8.5	19.8	-0.4	-4.5	-2.1	-4.2	-3.8	-2.7	3.8	0.7	1.9	-1.0	-3.1
Mother’s age at death	1.0	1.3	4.6	0.2	0.7	0.6	0.7	0.9	1.6	-1.6	-1.1	0.4	2.2	1.0
Financial situation satisfaction	0.3	0.4	1.4	-0.4	-0.3	0.7	-0.4	-0.8	-0.7	0.7	-1.2	-0.0	-0.5	-0.6
Tinnitus: Yes, now most or all of the time	3.9	4.6	9.8	0.8	-3.1	-1.9	-2.9	-2.6	-1.7	2.9	0.3	1.2	-2.2	-1.9
Commuting to job workplace: Public transport	0.9	1.1	3.5	1.0	-1.2	-0.3	-0.9	0.5	1.2	-0.3	-1.3	1.9	0.6	1.0
Eye problems/disorders: Glaucoma	2.3	2.7	6.9	2.3	-1.9	-1.1	-1.9	1.5	2.1	-0.5	0.5	2.6	0.4	1.3
Medication: Blood pressure	1.4	2.6	6.3	-0.5	2.5	1.6	2.3	2.0	0.1	-0.5	-2.2	-1.9	0.4	1.3
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.5	0.1	1.2	-0.1	0.7	0.9	0.9	-0.6	-1.2	-0.8	0.5	1.0
Supplements: Fish oil (including cod liver oil)	1.9	2.4	6.8	-2.0	1.9	1.0	1.7	-1.1	-1.1	0.5	1.4	-2.6	1.3	-1.5
High cholesterol (Self-reported)	1.0	1.7	4.4	1.5	0.3	-0.9	0.6	2.0	1.4	-1.2	1.4	1.3	-0.3	2.1
Medication: Bendroflumethiazide	1.0	1.6	6.5	0.9	1.3	0.9	1.5	2.5	0.5	-0.6	-1.0	-0.7	-0.2	1.8
Medication: Paracetamol	0.8	1.3	2.0	-1.4	0.8	1.4	0.7	-1.3	-1.3	1.2	-0.6	-1.3	-0.2	-1.4
Medication: Lisinopril	1.6	2.1	5.2	2.3	-1.8	-1.8	-1.8	1.3	0.3	0.4	0.6	2.2	-0.5	0.6
Medication: Atorvastatin	0.4	0.5	1.6	0.1	0.8	-0.3	0.9	-0.5	-1.2	-0.3	-0.5	-0.6	0.4	-0.8
Illnesses of father: High blood pressure	0.7	0.8	2.9	-0.3	1.4	0.8	1.4	0.0	-0.7	-0.1	0.6	-1.7	-0.9	0.3
Alcohol drinker status: Never	1.9	2.2	7.5	-2.3	0.9	0.4	0.9	-1.4	-1.2	0.7	0.0	-2.7	1.6	-1.8
Ever smoked	0.5	0.9	8.0	0.0	-0.8	-0.2	-0.5	-0.4	-0.5	-0.0	2.8	0.7	0.5	-0.4
Basal metabolic rate	0.5	2.6	18.1	0.1	-1.3	0.1	-1.3	-1.2	-1.0	1.3	-4.2	0.7	-1.0	-1.1
Leg fat percentage (left)	1.0	3.7	10.1	2.2	-3.0	-1.0	-2.9	0.6	1.8	0.4	-1.9	3.2	0.1	0.6
Arm fat-free mass (left)	0.4	2.3	16.0	0.2	-1.0	-0.0	-0.8	-1.2	-0.9	1.2	-4.0	0.5	-1.4	-1.0
Number of operations (self-reported)	1.0	1.5	5.0	1.0	-1.6	-1.5	-1.6	0.2	-0.1	0.3	2.2	1.5	-0.9	0.3
Average weekly beer plus cider intake	1.5	2.2	6.0	-1.9	-0.1	-0.1	-0.3	-2.2	-2.4	1.2	-0.7	-1.4	-0.2	-2.3
Irritability	0.6	1.0	4.4	-1.1	0.2	0.5	0.1	-2.1	-0.7	0.6	0.0	-0.5	-1.8	-0.9
Risk taking	0.5	0.7	2.6	-1.3	-0.0	-1.6	-0.6	-0.7	-0.3	0.2	0.5	-0.7	-0.9	-0.8
Ever had prostate specific antigen (PSA) test	0.2	0.2	1.4	-0.5	0.3	-0.5	0.5	0.5	0.0	0.0	-1.2	0.0	-0.1	0.4
Fractured/broken bones in last 5 years	1.3	1.7	6.1	0.2	-2.5	-1.5	-2.4	-0.4	-1.0	-0.1	-0.1	1.8	0.4	-0.7
Age started oral contraceptive pill	0.5	0.6	2.1	-0.9	-0.3	1.4	-0.6	-0.3	-0.2	0.7	-1.4	0.7	0.7	0.0
Diastolic blood pressure, automated reading	2.1	6.6	21.8	4.7	-1.3	-1.3	-0.5	2.5	2.6	-2.0	-1.9	3.1	-2.7	3.1
Ever depressed for a whole week	1.3	1.6	7.0	-0.2	0.5	0.1	0.6	-0.9	-1.7	2.6	-1.8	-1.2	-0.6	-1.1
Unable to work because of sickness or disability	0.5	0.7	2.9	-0.4	0.5	-0.3	0.8	-0.2	-0.6	-0.4	-1.5	-0.6	1.7	-0.7
Commuting to job workplace: Cycle	1.3	1.6	4.0	-0.4	1.7	-0.9	1.8	1.6	1.2	-2.0	1.1	-0.6	-0.5	1.1
Myopia	0.4	0.6	2.4	-0.7	1.1	0.4	1.6	-0.9	-0.5	0.0	0.1	-0.8	0.7	-0.4
Vascular/heart problems diagnosed by doctor	0.8	2.3	6.5	-0.4	-2.2	-1.1	-1.9	-2.5	-0.6	0.6	1.7	1.2	0.4	-1.7
Cholesterol lowering medication	0.7	1.0	4.2	-0.1	-0.9	-1.0	-0.7	-1.1	-1.2	-0.4	0.7	0.4	-2.0	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	-0.3	0.3	0.8	0.3	0.6	0.3	0.1	-0.2	-0.2	-0.6	0.7
Pain experienced in last month	0.5	0.8	3.8	0.9	-0.5	-0.0	-0.1	0.9	0.4	-0.7	2.0	0.9	1.1	0.6
Supplements: Calcium	0.2	0.2	1.1	0.5	0.2	-1.1	-0.4	0.1	-0.5	0.0	-0.1	-0.2	0.2	0.2
Basal cell carcinoma (self-reported)	1.0	1.2	6.8	0.1	1.4	0.9	1.3	0.4	0.6	-0.1	-2.6	-0.8	0.7	0.6
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.5	0.6	0.4	-1.6	0.1	0.8	0.6	-0.5	1.2	-0.9	0.6	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	3.7	-1.9	0.1	0.6	0.0	-1.0	-0.8	0.2	-0.1	-1.0	1.3	-1.8
Heart disease (siblings)	0.4	0.5	1.4	-0.9	1.2	-0.5	0.3	0.9	0.2	0.5	0.8	-0.5	0.5	0.6
Alcohol drinker status: Previous	1.0	1.1	4.4	1.0	1.1	0.7	1.2	0.8	0.6	-2.1	-1.0	0.1	-0.3	1.3
Pack years of smoking	1.9	2.7	6.4	2.2	-2.1	-2.5	-1.8	0.5	1.0	0.4	0.3	2.0	-2.2	1.1
Impedance of whole body	0.8	4.0	10.6	2.6	-2.9	-1.3	-2.2	0.2	1.7	-1.3	2.6	3.3	-0.6	0.6
Leg fat mass (left)	0.9	3.5	8.9	1.7	-3.0	-0.9	-2.8	-0.5	0.9	0.7	-2.9	2.8	-0.2	-0.3
Arm predicted mass (left)	0.4	2.2	14.3	0.5	-1.3	-0.2	-1.1	-1.2	-0.7	1.0	-3.8	0.8	-1.5	-0.9