TWAS hub - TSPYL6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0716	0.0292	1.3e-03	0.034	0.036	0.046	0.042	0.049	2.9e-05	1.7e-05	1.3e-06	3.2e-06	6.5e-07
2	TCGA	Brain Lower Grade Glioma	0.0883	0.0368	1.2e-06	0.054	0.059	0.040	NA	0.059	8.3e-07	2.9e-07	2.4e-05	NA	2.8e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Heel T-Score	20.0	158.8	187.7	13.7	11.4
Heel bone mineral density (BMD) T-score, automated (right)	11.0	25.1	32.9	5.7	4.2
Heel bone mineral density (BMD) T-score, automated (left)	9.5	21.5	29.2	5.4	3.7
Tinnitus: Yes, now most or all of the time	7.9	9.2	12.5	-2.4	-3.5
Handedness (chirality/laterality): Left-handed	5.3	6.4	6.6	-2.5	-2.6
Average weekly champagne plus white wine intake	5.0	6.9	7.6	-2.8	-2.5
Had major operations	4.7	5.5	6.8	-2.6	-2.0
Commuting to job workplace: Cycle	4.2	5.0	6.0	2.4	2.0
Medication: Atorvastatin	3.9	4.8	5.9	-2.0	-2.4
Qualifications: O levels/GCSEs or equivalent	3.7	5.9	6.3	2.4	2.5
Average weekly spirits intake	3.5	4.3	4.5	2.0	2.1
Medication: Bendroflumethiazide	3.5	5.4	6.3	-2.1	-2.5
Maternal smoking around birth	3.4	4.9	5.0	-2.2	-2.2
Tense / ‘highly strung’	3.4	5.6	7.5	1.9	2.7
Osteoporosis (self-reported)	3.4	4.2	4.9	-1.9	-2.2
Wears glasses or contact lenses	3.4	3.9	4.8	-2.2	-1.8
Tinnitus: Yes, but not now, but have in the past	3.1	3.3	4.1	2.0	1.6
Number of operations (self-reported)	3.1	4.6	6.8	-1.5	-2.6
Supplements: Calcium	3.1	3.4	4.0	-1.7	-2.0
Alcohol drinker status: Previous	3.1	3.5	3.6	-1.8	-1.9
Time employed in main current job	2.9	3.4	4.3	-1.6	-2.1
Commuting to job workplace: Car/motor vehicle	2.9	3.3	4.5	2.1	1.4
Illnesses of father: High blood pressure	2.8	3.5	6.0	-1.0	-2.5
Prostate Cancer	2.5	3.5	4.4	2.1	1.6
Systolic Blood Pressure	2.5	12.5	15.0	-3.9	-3.2
Diastolic blood pressure, automated reading	2.5	7.7	9.5	-3.1	-2.4
Ever highly irritable/argumentative for 2 days	2.3	2.8	3.8	1.3	2.0
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.8	6.4	-1.8	-2.5
Vitamin and mineral supplements	2.2	3.0	3.1	1.8	1.7
Multivitamins +/- minerals	2.2	2.8	3.6	-1.4	-1.9
Lung cancer (father)	2.2	2.6	2.9	1.7	1.5
Illnesses of father: Heart disease	2.1	2.9	4.2	2.0	1.3
Rheumatoid Arthritis	2.0	2.7	3.0	-1.6	-1.7
Lung FEV1/FVC ratio	2.0	10.2	12.8	-2.8	-3.6
Nervous feelings	2.0	3.7	4.5	2.1	1.7
Arm fat-free mass (left)	2.0	10.2	15.4	-2.2	-3.9
Arm predicted mass (left)	2.0	9.9	15.2	-2.1	-3.9
Fasting Glucose	1.9	2.3	3.2	1.2	1.8
Trunk fat-free mass	1.9	11.1	16.7	-2.3	-4.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	5.9	6.6	-2.3	-2.6
Trunk predicted mass	1.9	11.0	16.6	-2.3	-4.1
Overall health rating	1.9	4.2	5.0	-1.8	-2.2
Happiness	1.8	2.2	3.0	-1.7	-1.2
Cholesterol lowering medication	1.8	2.7	3.5	-1.4	-1.9
Alzheimer’s Disease (including proxy)	1.7	2.5	2.7	1.5	1.6
Cardiovascular Disease	1.7	5.7	7.1	-2.1	-2.7
Loud music exposure frequency	1.7	1.9	2.7	-1.1	-1.6
Hypertension (Self-reported)	1.7	4.7	6.2	-1.8	-2.5
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	4.8	-2.2	-0.7
Alzheimer’s Disease (in mother)	1.6	1.8	1.9	1.4	1.3
Chronotype (morning person)	1.6	3.6	4.2	-2.0	-1.7
Systolic blood pressure, automated reading	1.6	4.6	4.7	-2.1	-2.2
Serious illness, injury or assault to yourself	1.6	1.9	3.6	-0.5	-1.9
High blood pressure	1.6	4.4	6.3	-1.6	-2.5
Exposure to tobacco smoke outside home	1.6	2.1	2.7	-1.3	-1.6
Suffer from ‘nerves’	1.6	2.6	3.2	1.8	1.4
Medication: Blood pressure	1.6	3.0	4.6	-1.2	-2.1
Unable to work because of sickness or disability	1.6	2.0	2.8	-1.1	-1.7
Worry (Nagel 2018)	1.5	3.1	3.8	1.5	1.9
Ulcerative Colitis (UC)	1.5	2.9	3.5	1.5	1.9
Had other major operations	1.5	1.8	3.3	-0.5	-1.8
Blood clot in the leg (DVT)	1.5	1.9	2.9	1.7	1.0
Medication: Amlodipine	1.5	2.1	3.0	-1.1	-1.7
Breast cancer (self-reported)	1.5	1.8	1.9	-1.4	-1.3
Qualifications: CSEs or equivalent	1.4	1.9	3.2	-1.8	-0.8
Ever had bowel cancer screening	1.4	1.7	2.5	1.6	0.9
Whole body water mass	1.4	8.2	12.5	-2.0	-3.5
Irritability	1.4	2.4	3.1	1.3	1.8
Impedance of arm (left)	1.3	6.1	6.6	2.4	2.6
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.3	1.0	1.5
Whole body fat-free mass	1.3	7.4	11.4	-1.9	-3.4
Commuting to job workplace: Public transport	1.3	1.5	2.4	0.8	1.5
High cholesterol (Self-reported)	1.3	2.3	3.2	-1.8	-1.2
Basal metabolic rate	1.3	7.1	11.1	-1.8	-3.3
HDL Cholesterol	1.2	2.0	2.9	1.1	1.7
High blood pressure (siblings)	1.2	1.8	2.9	-0.8	-1.7
Worry too long after embarrassment	1.2	2.0	2.4	1.3	1.5
Leg pain on walking	1.2	1.5	2.0	-1.0	-1.4
Guilty feelings	1.2	1.7	2.4	-1.1	-1.5
Medication: Lisinopril	1.2	1.5	2.2	-0.9	-1.5
Pain experienced in last month	1.2	2.0	2.0	-1.4	-1.4
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	2.4	1.6	0.9
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.3	-0.5	-1.5
Financial difficulties in last 2 years	1.1	1.5	2.6	-0.7	-1.6
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	4.2	-1.8	-2.1
Eye problems/disorders: None of the above	1.1	1.2	1.6	-1.0	-1.2
Medication: Ibuprofen	1.1	1.3	1.4	-1.1	-1.2
Supplements: Vitamin C	1.1	1.3	2.1	0.6	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	1.8	0.9	1.3
Average weekly red wine intake	1.1	1.6	1.8	-1.2	-1.3
Mineral and other dietary supplements	1.1	1.5	2.7	0.6	1.6
Basal cell carcinoma (self-reported)	1.1	1.4	2.3	1.5	0.6
Coronary Artery Disease (CAD)	1.0	1.2	2.2	1.5	0.4
Hand grip strength (left)	1.0	2.5	3.1	1.4	1.8
Hair/balding pattern: Pattern 3	1.0	1.5	1.6	1.3	1.2
Arm fat-free mass (right)	1.0	5.1	8.7	-1.2	-3.0
Medication: Aspirin	1.0	1.3	1.9	1.4	0.9
Myopia	1.0	1.5	1.8	-1.3	-1.1
Impedance of whole body	1.0	5.1	5.6	2.1	2.4
Triglycerides	0.9	1.5	2.2	-0.9	-1.5
Height	0.9	18.0	31.8	-2.0	-5.6
Supplements: Zinc	0.9	1.0	1.2	-1.1	-0.9
Leg fat-free mass (left)	0.9	4.6	7.3	-1.4	-2.7
Had menopause	0.9	1.1	1.7	1.3	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	1.3	-1.0	-1.1
Exposure to tobacco smoke at home	0.9	1.0	1.1	1.1	0.9
Arm predicted mass (right)	0.9	4.4	7.4	-1.2	-2.7
Illnesses of siblings: Diabetes	0.9	1.1	1.3	1.0	1.1
Back pain experienced in last month	0.9	1.2	2.1	-0.6	-1.5
Medication: Aspirin	0.9	1.1	1.7	1.3	0.8
LDL Cholesterol	0.8	1.3	2.4	-1.6	-0.5
Leg predicted mass (left)	0.8	4.5	7.0	-1.4	-2.6
Heart attack	0.8	1.0	1.5	1.2	0.8
Medication: Paracetamol	0.8	1.4	1.6	1.3	1.1
Forced vital capacity (FVC), Best measure	0.8	2.8	3.2	-1.6	-1.8
Shortness of breath walking on level ground	0.8	1.0	1.1	0.9	1.1
Alcohol intake frequency.	0.8	1.9	2.0	-1.4	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.3	1.2	0.8
Qualifications: nursing, teaching	0.8	1.2	1.6	1.3	0.9
Alcohol drinker status: Never	0.8	1.0	1.4	0.8	1.2
Average weekly beer plus cider intake	0.8	1.2	1.8	1.3	0.8
Mean Putamen Volume	0.7	0.8	1.0	1.0	0.7
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.7	1.3	0.6
Mouth/teeth dental problems	0.7	1.1	1.2	1.1	1.1
Illnesses of siblings	0.7	1.0	1.4	0.8	1.2
Weight	0.7	3.2	5.9	-0.8	-2.4
Hip circumference	0.7	3.0	5.1	-1.0	-2.2
Alcohol intake versus 10 years previously	0.7	1.1	1.2	-1.0	-1.1
Length of working week for main job	0.7	0.8	1.3	0.5	1.2
Number of full brothers	0.7	0.9	1.6	1.2	0.5
Wheeze or whistling in the chest in last year	0.7	1.3	1.8	-1.3	-0.9
Leg fat-free mass (right)	0.7	3.7	5.8	-1.3	-2.4
Loneliness, isolation	0.7	1.0	1.6	-0.6	-1.3
Osteoarthritis (self-reported)	0.7	0.9	1.8	1.3	-0.3
Mother’s age at death	0.7	0.9	1.0	0.8	1.0
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.0	0.8	1.7
Schizophrenia (2018)	0.6	1.3	1.7	1.3	1.0
Alzheimer’s Disease (in father)	0.6	0.7	1.1	0.6	1.0
Neuroticism (2016)	0.6	0.8	0.9	0.8	1.0
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.1	-0.6	-1.0
Ever had hysterectomy (womb removed)	0.6	0.7	0.9	0.7	-1.0
Diabetes (mother)	0.6	0.7	1.3	-1.1	-0.4
Impedance of leg (left)	0.6	2.9	3.2	1.6	1.8
Worrier / anxious feelings	0.6	1.1	2.2	-1.5	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.4	-1.2	-0.0
Medication: Lansoprazole	0.6	0.7	1.2	1.1	0.4
Peak expiratory flow (PEF)	0.6	1.4	1.4	-1.2	-1.2
Age at first live birth	0.6	1.1	1.9	0.5	1.4
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.2	-0.5	-1.1
Neck or shoulder pain in last month	0.6	0.9	1.5	-0.5	-1.2
Comparative height size at age 10	0.6	3.4	6.7	-0.3	-2.6
Friendships satisfaction	0.6	0.8	1.4	1.2	0.4
Commuting to job workplace: Walk	0.6	0.7	1.1	-1.1	-0.4
Leg predicted mass (right)	0.6	3.4	5.5	-1.2	-2.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.2	1.1	0.7
Pack years of smoking	0.6	0.9	1.8	0.2	1.3
Irritable Bowel Disease (IBD)	0.5	1.2	1.3	1.1	1.1
Age at First Birth	0.5	0.7	1.4	0.3	1.2
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.3	1.2	0.7
Neuroticism	0.5	1.2	2.1	0.6	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	0.7	0.8	0.8
High blood pressure (mother)	0.5	0.7	1.3	-0.4	-1.2
Smoking status: Previous	0.5	0.7	1.3	1.1	0.3
Heart disease (siblings)	0.5	0.6	0.8	0.6	0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	-0.5	-0.9
Medication: Metformin	0.4	0.6	0.9	-0.4	-1.0
Pack years adult smoking proportion	0.4	0.6	1.1	0.0	1.1
Average weekly fortified wine intake	0.4	0.5	0.8	0.9	0.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.5	0.6	0.7
Prospective memory result	0.4	0.5	0.5	-0.7	-0.7
Arm fat mass (right)	0.4	1.7	3.0	-0.6	-1.7
Standing height	0.4	4.1	8.1	-0.3	-2.9
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.7	-0.5	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.8	0.4	0.9
Medication: Allopurinol	0.4	0.5	1.0	-0.3	-1.0
Medication: Seretide 50 evohaler	0.4	0.5	0.9	-0.2	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.5	-0.7	-0.7
Chest pain or discomfort	0.4	0.6	0.7	0.8	0.8
Age at last live birth	0.4	0.5	1.1	0.1	1.0
Family relationship satisfaction	0.4	0.5	0.9	0.9	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.8	-0.5	-0.9
Bipolar Disorder (2018)	0.3	0.4	0.5	-0.7	-0.6
Depressed Affect (Nagel 2018)	0.3	0.6	0.7	-0.8	-0.7
Crohns Disease (2012)	0.3	0.5	0.6	-0.8	-0.6
Schizophrenia (2014)	0.3	0.6	1.1	1.1	0.3
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.6	0.8	0.2
Lung FVC	0.3	1.5	2.3	0.8	1.5
Diabetes (father)	0.3	0.3	0.4	0.6	0.5
Relative age voice broke	0.3	0.5	0.6	0.8	0.6
Waist circumference	0.3	1.1	2.0	-0.5	-1.4
Past tobacco smoking	0.3	0.6	1.2	0.0	1.1
Forced vital capacity (FVC)	0.3	1.0	1.2	-0.9	-1.1
Medication: Simvastatin	0.3	0.4	0.7	-0.8	-0.4
Impedance of arm (right)	0.3	1.4	1.6	1.1	1.3
Depression (self-reported)	0.3	0.3	0.4	0.4	0.7
Hair/balding pattern: Pattern 4	0.3	0.6	0.9	0.6	0.9
Birth weight of first child	0.3	0.6	0.7	-0.7	-0.9
Headache pain in last month	0.3	0.5	0.6	0.8	0.6
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.7	-0.3	-0.8
Heart disease (mother)	0.3	0.4	0.7	-0.8	-0.4
Leg fat mass (right)	0.3	1.3	2.4	-0.4	-1.6
Medication for cholesterol	0.3	0.5	1.0	0.1	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.1	-1.1	-0.4
Arm fat mass (left)	0.3	1.0	1.9	-0.4	-1.4
Eye problems/disorders: Glaucoma	0.3	0.3	0.5	0.4	0.7
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	0.3	-0.8
Risk taking	0.3	0.5	0.9	0.9	-0.2
Age started oral contraceptive pill	0.3	0.4	0.5	0.7	0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.6	0.8	0.2
Schizophrenia vs Biploar Disorder	0.2	0.3	0.4	-0.3	-0.7
Breast Cancer	0.2	0.4	0.9	0.2	-0.9
Bipolar Disorder (2011)	0.2	0.2	0.4	-0.3	-0.6
Blood Eosinophil Count	0.2	1.8	2.1	1.4	1.2
Waist Hip Ratio (WHR)	0.2	0.8	1.1	-0.7	-1.0
Number of treatments/medications taken	0.2	0.4	0.8	-0.0	-0.9
Medication: Co-codamol	0.2	0.3	0.4	0.4	-0.7
Impedance of leg (right)	0.2	1.0	1.2	1.1	0.9
Current tobacco smoking	0.2	0.3	0.5	-0.2	-0.7
Sitting height	0.2	1.4	2.8	0.1	-1.7
Body mass index (BMI)	0.2	0.9	1.3	-0.6	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	0.1	0.8
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	-0.1	-0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.6	-0.2
Qualifications: None of the above	0.2	0.5	0.5	-0.6	-0.7
Pain all over the body in last month	0.2	0.3	0.5	-0.1	-0.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	-0.7	-0.1
Neuroticism score	0.2	0.4	0.6	0.4	0.8
Pulse rate	0.2	0.3	0.3	-0.5	-0.5
Noisy workplace	0.2	0.2	0.4	0.7	0.2
Pulse wave Arterial Stiffness index	0.2	0.3	0.3	-0.5	-0.5
Breastfed as a baby	0.2	0.3	0.5	-0.1	-0.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.7	0.2	0.8
Glaucoma (self-reported)	0.2	0.2	0.4	-0.1	0.7
Pulse wave peak to peak time	0.2	0.2	0.2	0.5	0.4
Mean time to correctly identify matches	0.2	0.3	0.4	0.6	0.6
Number of full sisters	0.2	0.3	0.5	-0.1	-0.7
Medication: Gliclazide	0.2	0.2	0.3	0.1	-0.6
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	0.1	0.7
Smoking status: Current	0.2	0.4	0.6	-0.4	-0.8
Financial situation satisfaction	0.2	0.2	0.4	0.6	0.0
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.3	0.6	0.5
Fractured/broken bones in last 5 years	0.2	0.3	0.5	0.0	-0.7
Ever depressed for a whole week	0.2	0.2	0.4	-0.6	-0.2
Leg fat mass (left)	0.2	0.9	1.7	-0.2	-1.3
Bipolar Disorder or Schizophrenia	0.1	0.2	0.3	0.6	0.4
Depression (Nagel 2018)	0.1	0.2	0.4	0.6	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.3	0.6	-0.4
Neuroticism (Nagel 2018)	0.1	0.3	0.5	0.4	0.7
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.6	0.8	0.0
Ovarian Cancer	0.1	0.1	0.3	0.0	-0.5
Primary Biliary Cirrhosis	0.1	0.2	0.3	0.6	0.1
Blood Red Count	0.1	0.7	1.1	-1.0	0.6
Smoking Status	0.1	0.1	0.2	0.2	-0.5
Respiratory disease	0.1	0.2	0.3	-0.6	-0.0
Sensitivity / hurt feelings	0.1	0.2	0.4	0.2	0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	0.0	0.4
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.0	-0.4
Trunk fat percentage	0.1	0.2	0.4	0.7	0.1
Hand grip strength (right)	0.1	0.3	0.3	-0.6	-0.4
Townsend deprivation index at recruitment	0.1	0.1	0.3	-0.1	-0.5
Taking other prescription medications	0.1	0.1	0.1	-0.2	-0.4
Age when periods started (menarche)	0.1	0.2	0.3	0.6	0.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	-0.4	-0.5
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.5	-0.1
Medication: Atenolol	0.1	0.1	0.2	0.4	0.3
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.5	-0.0
Trunk fat mass	0.1	0.4	0.6	0.3	-0.8
Number of incorrect matches in round	0.1	0.2	0.3	-0.5	0.4
Diabetes (self-reported)	0.1	0.1	0.2	0.0	-0.5
Medication: Ramipril	0.1	0.2	0.3	0.3	-0.5
Fluid intelligence score	0.1	0.2	0.2	0.4	0.5
Arm fat percentage (right)	0.1	0.4	0.8	-0.3	-0.9
Father’s age at death	0.1	0.2	0.2	-0.4	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.2	-0.3	-0.5
Falls in the last year	0.1	0.2	0.3	0.4	-0.5
Number of live births	0.1	0.2	0.4	0.6	0.1
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	0.4	0.1
Asthma	0.1	0.2	0.3	0.3	0.6
Illnesses of mother	0.1	0.1	0.1	0.3	-0.2
Gout (self-reported)	0.1	0.2	0.3	0.1	-0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.2	0.3	0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	-0.6	0.1
Birth weight	0.1	0.3	0.5	0.2	-0.7
Leg fat percentage (right)	0.1	0.5	0.9	-0.3	-1.0
Comparative body size at age 10	0.1	0.3	0.6	0.8	-0.1
Number of children fathered	0.1	0.1	0.1	-0.3	-0.3
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.5	0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	-0.6	-0.1
Medication: Blood pressure	0.1	0.2	0.4	-0.2	-0.6
Migraine (self-reported)	0.1	0.1	0.1	0.4	-0.2
Medication: Omeprazole	0.1	0.1	0.2	0.5	-0.0
Whole body fat mass	0.1	0.5	0.9	0.1	-1.0
Knee pain experienced in last month	0.1	0.2	0.2	-0.4	-0.4
Long-standing illness, disability or infirmity	0.1	0.2	0.4	0.0	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.1	0.4
Miserableness	0.1	0.2	0.4	-0.6	-0.1
Ever taken oral contraceptive pill	0.1	0.1	0.1	-0.0	-0.4
Hearing aid user	0.1	0.1	0.1	0.2	0.3
Ever smoked	0.1	0.2	0.5	0.1	-0.7
Crohns Disease (2017)	0.0	0.1	0.1	0.3	0.3
Major Depression (MDD)	0.0	0.0	0.1	0.2	0.1
Reaction Time	0.0	0.0	0.0	-0.1	0.2
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.1	-0.1
HbA1C	0.0	0.0	0.0	0.2	0.2
Lupus	0.0	0.0	0.0	0.2	0.1
Ulcerative Colitis	0.0	0.0	0.0	0.2	0.2
Blood Platelet Count	0.0	0.0	0.0	0.1	0.0
Blood White Count	0.0	0.1	0.1	-0.3	0.4
BMI	0.0	0.1	0.2	-0.2	-0.4
Allergy or Eczema	0.0	0.0	0.0	-0.1	-0.1
Hypothyroidism (self reported)	0.0	0.0	0.0	0.1	-0.0
Hair Pigment	0.0	0.3	0.4	0.4	-0.6
Tanning	0.0	0.6	1.1	-1.1	-0.3
Hearing difficulty/problems: Yes	0.0	0.0	0.0	-0.1	0.2
Relative age of first facial hair	0.0	0.0	0.1	-0.3	-0.0
Angina	0.0	0.0	0.0	0.1	0.2
Severe depression (siblings)	0.0	0.0	0.0	0.1	0.0
Fed-up feelings	0.0	0.0	0.0	0.1	0.0
Supplements: Glucosamine	0.0	0.1	0.1	0.1	0.3
Medication: Levothyroxine sodium	0.0	0.0	0.0	0.1	-0.2
Alcohol usually taken with meals	0.0	0.0	0.0	0.0	-0.1
Hearing difficulty/problems with background noise	0.0	0.0	0.0	-0.0	-0.1
Allergy	0.0	0.0	0.0	0.2	0.1
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.1	-0.2	0.3
Medication: Cholesterol lowering	0.0	0.1	0.1	-0.3	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.0	-0.1	-0.0
Pulse wave reflection index	0.0	0.0	0.0	0.1	-0.2
Body fat percentage	0.0	0.1	0.1	0.3	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.1	0.1	0.1	0.3
Health satisfaction	0.0	0.1	0.1	0.2	0.3
Qualifications: College or University degree	0.0	0.1	0.2	-0.3	-0.5
Angina (self-reported)	0.0	0.0	0.0	-0.0	0.1
Pulse rate, automated reading	0.0	0.0	0.0	-0.2	0.1
Arm fat percentage (left)	0.0	0.0	0.0	0.2	-0.2
Mood swings	0.0	0.1	0.1	-0.2	-0.3
Diabetes diagnosed by doctor	0.0	0.0	0.0	0.0	-0.1
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.3	0.0
Asthma (self-reported)	0.0	0.1	0.1	0.2	0.3
Number of self-reported non-cancer illnesses	0.0	0.0	0.0	0.1	0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	-0.1	-0.0
Medication: Paracetamol	0.0	0.0	0.0	0.2	-0.1
Leg fat percentage (left)	0.0	0.1	0.2	0.0	-0.4

Hub : Genes

TSPYL6

Models

Trait associations