[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr3:48,515,079-50,800,146

Best TWAS P=1e-11 · Best GWAS P=8.32e-12 conditioned to 0.368

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	GTEx	Heart Left Ventricle	AMT	0.07	0.02	lasso	7	0.02	4.6e-02	6.3	6.8	1.0e-11	0.82	0.07	0.72	TRUE
32	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RBM6	0.19	0.07	blup	78	0.12	6.9e-06	-4.6	-5.1	3.1e-07	-0.42	0.10	0.80	TRUE
16	GTEx	Lung	TCTA	0.09	0.01	enet	10	0.03	3.3e-03	6.3	6.8	1.3e-11	0.69	0.03	0.60	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	FAM212A	0.07	0.02	bslmm	286	0.03	5.0e-05	6.8	-6.5	1.2e-10	-0.82	0.02	0.98	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	TCTA	0.04	0.04	blup	24	0.03	3.6e-04	6.3	6.4	1.9e-10	0.74	0.01	0.97	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	MST1R	0.08	0.07	enet	10	0.09	2.6e-10	4.5	6.4	2.0e-10	0.77	0.23	0.77	FALSE
15	GTEx	Heart Left Ventricle	NICN1-AS1	0.09	0.00	enet	8	0.01	1.0e-01	6.8	6.3	2.2e-10	0.83	0.04	0.79	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	BSN-AS2	0.07	0.10	lasso	6	0.09	3.5e-12	6.3	-6.3	2.4e-10	-0.83	0.18	0.82	FALSE
31	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CAMKV	0.07	0.05	enet	9	0.06	2.3e-03	4.5	6.3	2.5e-10	0.87	0.01	0.74	FALSE
18	GTEx	Testis	TRAIP	0.14	0.08	enet	22	0.08	1.9e-04	6.8	6.3	2.9e-10	0.86	0.01	0.96	FALSE
20	GTEx	Thyroid	RHOA-IT1	0.05	0.05	lasso	5	0.04	5.2e-04	6.3	-6.3	3.4e-10	-0.76	0.16	0.76	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RNF123	0.14	0.10	blup	324	0.12	4.7e-14	4.6	6.2	5.6e-10	0.79	0.62	0.38	FALSE
6	GTEx	Brain Cerebellar Hemisphere	FAM212A	0.25	0.17	lasso	21	0.20	8.1e-06	-4.5	6.1	8.2e-10	0.83	0.09	0.81	FALSE
5	GTEx	Brain Cerebellar Hemisphere	MST1R	0.30	0.08	enet	25	0.10	1.8e-03	4.4	6.0	2.5e-09	0.75	0.21	0.30	FALSE
9	GTEx	Brain Putamen basal ganglia	AMT	0.11	0.03	lasso	14	0.05	2.4e-02	-4.2	5.8	8.0e-09	0.66	0.06	0.43	FALSE
19	GTEx	Thyroid	TCTA	0.04	0.02	lasso	4	0.01	2.4e-02	-4.3	5.8	9.0e-09	0.59	0.24	0.58	FALSE
33	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RBM6	0.16	0.12	blup	79	0.09	4.4e-04	-4.5	-5.7	1.3e-08	-0.64	0.10	0.85	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RHOA	0.03	0.02	blup	294	0.02	1.0e-03	-4.4	-5.7	1.4e-08	-0.62	0.42	0.32	FALSE
13	GTEx	Esophagus Mucosa	RNF123	0.07	0.03	enet	9	0.04	1.8e-03	4.5	5.7	1.4e-08	0.86	0.08	0.88	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	AMT	0.02	0.00	blup	25	0.01	5.4e-02	-4.4	5.6	2.0e-08	0.57	0.02	0.33	FALSE
4	GTEx	Brain Cerebellar Hemisphere	AMT	0.40	0.42	enet	23	0.42	4.1e-12	-4.4	5.5	2.8e-08	0.53	1.00	0.00	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	TCTA	0.17	0.06	lasso	15	0.03	3.8e-02	-5.2	5.5	3.2e-08	0.61	0.36	0.12	FALSE
21	GTEx	Whole Blood	AMT	0.07	0.08	enet	37	0.09	1.1e-08	-4.5	5.5	3.4e-08	0.60	0.99	0.01	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	KLHDC8B	0.01	0.01	blup	255	0.01	1.0e-02	-3.7	-5.4	5.6e-08	-0.65	0.09	0.35	FALSE
11	GTEx	Colon Transverse	GPX1	0.11	0.01	lasso	5	0.01	8.8e-02	-3.8	-5.4	7.2e-08	-0.70	0.06	0.64	FALSE
10	GTEx	Colon Transverse	RBM6	0.29	0.33	enet	43	0.36	4.6e-18	-4.5	-5.3	9.5e-08	-0.63	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	RBM6	0.03	0.04	blup	79	0.05	9.5e-10	-4.5	-5.3	1.1e-07	-0.62	0.12	0.86	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRAIP	0.02	0.01	enet	8	0.01	3.1e-02	4.5	5.3	1.2e-07	0.87	0.01	0.74	FALSE
17	GTEx	Skin Sun Exposed Lower leg	GPX1	0.04	0.05	lasso	3	0.04	2.9e-04	-4.5	-5.3	1.3e-07	-0.50	0.62	0.07	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	RBM6	0.20	0.19	enet	29	0.22	2.0e-06	-4.5	-5.2	1.6e-07	-0.72	0.38	0.58	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	NICN1-AS1	0.23	0.09	lasso	13	0.05	2.1e-02	-4.5	-5.2	1.7e-07	-0.58	0.14	0.27	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	RBM6	0.21	0.32	enet	31	0.34	1.5e-44	-4.6	-5.2	1.9e-07	-0.58	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Colon Adenocarcinoma	UBA7	0.11	0.06	enet	5	0.05	7.6e-04	4.3	-5.2	1.9e-07	-0.78	0.21	0.78	FALSE
3	GTEx	Artery Aorta	UBA7	0.06	0.02	enet	12	0.01	5.3e-02	4.5	-5.1	3.1e-07	-0.66	0.27	0.36	FALSE