TWAS hub - RHOA-IT1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.0750	0.0400	0.0027	0.044	NA	0.030	NA	0.045	4.9e-03	NA	0.0170	NA	0.00440
2	GTEx	Nerve Tibial	0.0486	0.0309	0.0051	0.019	NA	0.027	NA	0.017	1.5e-02	NA	0.0047	NA	0.02200
3	GTEx	Thyroid	0.0450	0.0250	0.0018	0.054	NA	0.034	NA	0.040	5.4e-05	NA	0.0013	NA	0.00052

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Irritable Bowel Disease (IBD)	30.5	72.7	134.6	3.8	11.6	8.3
Crohns Disease (2017)	28.8	63.1	91.6	4.6	9.6	8.8
Crohns Disease (2012)	27.1	43.7	57.8	4.6	7.6	7.2
Qualifications: College or University degree	17.6	55.3	97.2	3.0	9.9	7.7
Ulcerative Colitis	17.1	24.7	56.3	1.6	7.5	3.9
Pulse rate, automated reading	17.0	54.8	80.5	-9.0	-3.1	-8.6
Ulcerative Colitis (UC)	16.4	30.8	74.0	1.3	8.6	4.1
Qualifications: A levels/AS levels or equivalent	15.6	34.6	57.8	2.8	7.6	6.2
Intelligence (Savage-Jansen 2018)	15.5	47.7	92.2	2.8	9.6	6.6
Average weekly spirits intake	13.6	16.8	26.6	-3.3	-5.2	-3.6
Trunk fat percentage	11.2	44.9	59.9	-6.3	-5.9	-7.7
Heel bone mineral density (BMD) T-score, automated (right)	11.2	25.8	40.2	-5.4	-2.8	-6.3
Pulse rate	10.6	17.9	26.6	-5.2	-0.9	-5.1
Body fat percentage	10.5	41.6	59.6	-5.3	-6.1	-7.7
Heel bone mineral density (BMD) T-score, automated (left)	10.2	23.0	39.4	-4.7	-2.7	-6.3
Arm fat percentage (left)	9.5	37.9	52.7	-4.7	-6.3	-7.3
Verbal and Numeric Reasoning (VNR)	9.1	21.9	34.5	2.0	5.9	5.2
Trunk fat mass	8.6	36.8	48.7	-5.6	-5.5	-7.0
Whole body fat mass	8.6	35.9	49.3	-4.7	-6.0	-7.0
Heel T-Score	8.5	67.9	92.0	-9.6	-4.8	-9.4
Arm fat percentage (right)	8.3	32.8	46.0	-3.9	-6.1	-6.8
Alcohol intake versus 10 years previously	8.3	12.3	17.3	-2.4	-3.7	-4.2
Leg fat percentage (left)	8.3	30.0	50.4	-2.7	-5.7	-7.1
Leg fat percentage (right)	8.2	29.8	49.3	-2.7	-5.8	-7.0
Fluid intelligence score	8.1	16.8	22.5	2.5	4.7	4.7
Qualifications: NVQ or HND or HNC or equivalent	7.8	9.4	13.9	-3.1	-2.2	-3.7
Leg fat mass (left)	7.8	30.4	46.0	-3.3	-5.9	-6.8
Leg fat mass (right)	7.7	29.8	45.3	-3.3	-5.8	-6.7
Arm fat mass (left)	7.5	30.7	42.2	-3.9	-5.9	-6.5
Arm fat mass (right)	7.4	30.3	41.9	-3.6	-6.0	-6.5
Frequency of tiredness / lethargy in last 2 weeks	7.3	11.8	23.1	4.8	-0.8	3.4
Ever had bowel cancer screening	6.9	8.1	11.9	2.9	2.1	3.4
Qualifications: nursing, teaching	6.9	10.8	15.4	1.6	3.8	3.9
Fed-up feelings	6.2	11.3	25.9	0.5	-5.1	-2.8
Medication: Seretide 50 evohaler	6.2	7.1	9.1	-1.8	-3.0	-3.0
Body mass index (BMI)	5.9	25.1	36.8	-1.5	-6.1	-6.0
Relative age voice broke	5.7	8.7	17.1	2.9	0.9	4.1
BMI	5.5	31.8	46.0	-2.5	-6.8	-6.6
Other serious medical condition/disability diagnosed by doctor	5.5	7.2	9.8	2.3	3.1	2.5
Wheeze or whistling in the chest in last year	5.4	9.6	16.6	-2.4	-4.1	-2.6
Fasting Glucose	5.3	6.3	10.2	-0.6	-2.9	-3.2
Irritability	5.2	8.9	19.9	4.5	1.2	2.3
Osteoporosis (self-reported)	5.1	6.3	13.3	2.3	0.4	3.6
Reaction Time	4.8	9.1	12.3	2.7	2.8	3.5
Age at First Birth	4.8	6.9	11.2	-0.8	3.3	3.0
Father’s age at death	4.6	6.1	13.3	0.0	3.6	2.2
Coronary Artery Disease (CAD)	4.4	5.2	6.7	-2.0	-2.2	-2.6
Tinnitus: Yes, but not now, but have in the past	4.4	4.7	9.8	-0.9	-3.1	-1.9
Qualifications: None of the above	4.4	9.4	19.7	0.6	-4.4	-2.9
Mean time to correctly identify matches	4.3	8.3	12.2	2.6	2.4	3.5
Medication for cholesterol, blood pressure or diabetes	4.2	7.0	13.3	2.5	1.2	3.6
Serious illness, injury or assault of a close relative in last 2 years	4.1	4.8	7.9	2.5	0.2	2.8
Happiness	3.9	4.7	5.9	2.4	1.9	2.2
Overall health rating	3.9	8.3	18.2	0.0	-4.3	-2.6
Diastolic blood pressure, automated reading	3.9	12.0	22.3	-0.6	-3.6	-4.7
Ever depressed for a whole week	3.9	4.8	9.4	3.1	-0.1	2.2
Weight	3.8	18.9	24.7	-3.2	-4.7	-5.0
Mouth/teeth dental problems: Bleeding gums	3.8	4.9	7.1	1.8	2.7	2.1
Bipolar Disorder (2011)	3.7	3.5	4.7	2.0	1.4	2.2
Waist circumference	3.7	13.6	24.7	-3.0	-2.6	-5.0
Qualifications: O levels/GCSEs or equivalent	3.7	6.0	14.3	0.3	3.8	1.9
Number of full brothers	3.7	4.6	12.2	3.5	0.0	1.3
Age at last live birth	3.6	5.2	11.6	-1.1	3.4	1.6
Had other major operations	3.5	4.3	7.2	2.7	0.5	2.4
Mouth/teeth dental problems: Dentures	3.5	5.8	9.2	-1.2	-3.0	-2.6
Leg pain on walking	3.5	4.3	7.7	-0.2	-2.8	-2.3
Average weekly beer plus cider intake	3.5	5.1	9.4	-1.7	-3.1	-1.7
Had menopause	3.3	4.1	7.1	0.8	2.7	2.2
Diabetes (self-reported)	3.3	5.2	10.3	-2.1	0.8	-3.2
Blood Red Count	3.2	30.8	63.0	-5.2	-1.6	-7.9
Medication: Cholesterol lowering	3.2	4.9	9.4	-2.2	-0.7	-3.1
Loud music exposure frequency	3.2	3.5	5.6	1.5	2.4	1.6
Alcohol intake frequency.	3.2	7.4	17.1	-1.3	-1.9	-4.1
Blood Eosinophil Count	3.1	23.8	61.6	-7.8	-1.0	-3.0
Medication: Co-codamol	3.1	3.5	8.4	0.8	-2.9	-1.2
Impedance of arm (left)	3.1	14.4	38.6	-6.2	2.1	-0.5
Hypothyroidism/myxoedema (self-reported)	3.1	6.1	12.5	3.5	1.7	1.8
Miserableness	3.1	5.3	11.7	1.8	-3.4	-1.0
Waist Hip Ratio (WHR)	3.0	13.7	25.7	-5.1	3.0	-2.5
Schizophrenia (2018)	2.9	6.1	8.3	2.9	2.2	2.3
Number of live births	2.9	4.1	6.9	-1.8	-1.5	-2.6
Fractured/broken bones in last 5 years	2.9	3.8	4.7	1.9	1.7	2.2
Depressed Affect (Nagel 2018)	2.8	5.8	12.4	1.6	-3.5	-1.6
Hand grip strength (left)	2.8	7.5	12.7	-2.4	-3.6	-2.0
Hand grip strength (right)	2.8	7.7	13.9	-2.4	-3.7	-1.9
Frequency of tenseness / restlessness in last 2 weeks	2.8	4.3	7.0	2.7	-2.3	0.9
Prospective memory result	2.8	3.5	4.9	-1.5	-2.2	-1.9
Age at first live birth	2.8	5.0	8.1	-2.1	2.8	1.7
Medication: Allopurinol	2.8	3.8	5.9	-2.2	-0.7	-2.4
Number of full sisters	2.8	3.4	8.7	3.0	1.2	-0.0
Diabetes diagnosed by doctor	2.8	4.6	8.4	-2.1	1.0	-2.9
Basal cell carcinoma (self-reported)	2.8	3.3	5.2	1.2	1.8	2.3
Bipolar Disorder or Schizophrenia	2.7	6.5	8.7	3.0	1.8	2.7
Schizophrenia (2014)	2.7	5.9	8.2	2.9	2.0	2.4
Severe depression (siblings)	2.7	3.0	4.9	1.6	1.3	2.2
Taking other prescription medications	2.7	4.1	10.9	0.0	-3.3	-1.2
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	7.3	2.7	-0.4	1.5
Peak expiratory flow (PEF)	2.7	6.3	8.7	2.4	2.9	2.1
Medication: Ventolin 100micrograms inhaler	2.7	3.4	4.1	-1.9	-1.6	-2.0
Supplements: Calcium	2.7	2.9	6.5	1.4	0.6	2.5
Prostate Cancer	2.6	3.7	8.4	1.1	-2.9	-1.3
Smoking Status	2.6	6.3	11.2	3.3	-1.8	2.1
Illnesses of siblings	2.6	3.6	9.2	-3.0	-1.2	-0.4
Pain experienced in last month	2.6	4.3	9.9	-0.8	3.1	1.5
Number of treatments/medications taken	2.5	4.5	7.2	-0.7	-2.7	-2.4
Pain all over the body in last month	2.5	2.6	5.2	1.6	-2.3	-0.3
Chest pain or discomfort	2.5	3.6	5.8	2.4	-1.3	1.8
Average weekly champagne plus white wine intake	2.5	3.4	6.0	0.8	1.9	2.5
Relative age of first facial hair	2.4	4.9	9.5	2.3	0.3	3.1
Pack years adult smoking proportion	2.4	3.7	9.4	3.1	-1.2	0.5
Gout (self-reported)	2.4	3.3	5.6	-2.0	-0.5	-2.4
Ever had prostate specific antigen (PSA) test	2.4	2.7	5.2	-2.3	-0.8	-1.5
Impedance of whole body	2.4	12.2	30.1	-5.5	2.2	-1.2
Age when periods started (menarche)	2.3	5.6	11.9	2.1	-3.5	0.6
Medication: Levothyroxine sodium	2.3	4.0	8.6	2.9	1.0	1.5
Impedance of arm (right)	2.3	10.7	27.9	-5.3	2.0	-0.1
Medication: Paracetamol	2.3	3.5	8.5	1.4	-2.9	0.1
Hypothyroidism (self reported)	2.2	5.1	12.9	3.6	1.0	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	3.0	6.5	-0.2	-2.5	-1.5
Qualifications: CSEs or equivalent	2.2	2.9	6.0	0.6	-2.4	-1.6
Glaucoma (self-reported)	2.2	2.6	6.2	1.1	2.5	0.6
Pack years of smoking	2.2	3.2	9.1	3.0	-0.5	0.6
Worry too long after embarrassment	2.0	3.3	8.7	-0.1	3.0	1.1
Mood swings	2.0	3.6	5.4	1.3	-2.3	-1.9
Triglycerides	1.9	3.1	5.1	-2.0	-0.2	-2.2
Ever had hysterectomy (womb removed)	1.9	2.1	5.0	-0.8	-2.2	-0.9
Hip circumference	1.9	8.3	12.8	-0.8	-3.6	-3.4
Pulse wave reflection index	1.9	2.4	4.6	1.4	0.7	2.1
Depression (self-reported)	1.8	2.1	3.5	1.9	-0.5	1.6
Loneliness, isolation	1.8	2.5	5.0	1.1	-2.2	-1.2
Guilty feelings	1.8	2.8	6.2	0.1	-2.5	-1.4
Age started oral contraceptive pill	1.8	2.2	3.8	-0.3	1.7	1.9
Major Depression (MDD)	1.7	2.0	4.9	2.2	-0.8	0.7
Breast Cancer	1.7	4.1	8.9	0.3	3.0	1.8
Type 2 Diabetes (T2D) (2018)	1.7	3.1	7.1	-1.5	0.3	-2.7
Supplements: Zinc	1.7	1.8	2.5	1.5	0.8	1.6
Medication: Metformin	1.7	2.4	4.7	-1.6	0.3	-2.2
Current tobacco smoking	1.7	2.7	4.9	1.6	-2.2	0.7
High blood pressure (mother)	1.7	2.4	5.7	1.2	2.4	0.0
Forced expiratory volume in 1-second (FEV1)	1.7	5.7	14.3	-0.6	3.8	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.5	13.2	-0.6	3.6	1.7
Osteoarthritis (self-reported)	1.7	2.2	5.2	0.6	-2.3	-1.0
Sensitivity / hurt feelings	1.6	2.7	7.3	0.5	2.7	0.7
Townsend deprivation index at recruitment	1.6	2.3	6.7	2.6	0.1	0.3
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	3.0	1.7	-0.8	1.5
Sitting height	1.6	11.2	28.2	-5.3	-0.6	-2.3
Tense / ‘highly strung’	1.6	2.7	6.5	2.5	-0.2	1.2
Medication: Paracetamol	1.6	2.6	5.5	1.5	-2.4	-0.1
Had major operations	1.6	1.9	3.4	1.9	-1.2	0.9
Primary Biliary Cirrhosis	1.5	2.1	3.8	1.4	0.7	2.0
Vitamin and mineral supplements	1.5	2.1	3.5	-1.9	0.1	-1.6
Diabetes (mother)	1.5	2.0	3.7	-1.4	-0.5	-1.9
Serious illness, injury or assault to yourself	1.5	1.8	2.9	1.7	0.4	1.5
Medication: Lansoprazole	1.5	1.7	2.5	-0.5	-1.6	-1.5
Smoking status: Current	1.5	2.4	5.1	1.4	-2.3	0.5
Number of operations (self-reported)	1.5	2.3	3.7	1.9	-1.5	0.9
HDL Cholesterol	1.4	2.3	3.0	1.6	1.1	1.7
Lupus	1.4	2.2	4.2	1.4	0.7	2.0
Neuroticism (2016)	1.4	2.0	4.5	0.1	-2.1	-1.3
Bilateral oophorectomy (both ovaries removed)	1.4	1.7	2.8	-0.8	-1.7	-1.2
Financial difficulties in last 2 years	1.4	1.8	3.9	0.4	-1.2	-2.0
Hair/balding pattern: Pattern 3	1.4	2.2	3.9	-1.1	-2.0	-1.1
Illnesses of mother	1.4	1.7	4.1	0.8	-0.6	2.0
Pulse wave Arterial Stiffness index	1.4	1.6	3.8	-1.9	-0.8	-0.8
Exposure to tobacco smoke at home	1.4	1.6	2.4	0.2	-1.6	-1.5
Hair/balding pattern: Pattern 4	1.4	3.3	4.9	-1.0	-2.0	-2.2
Exposure to tobacco smoke outside home	1.4	1.9	5.3	0.5	-2.3	-0.4
Illnesses of father: High blood pressure	1.4	1.7	3.0	-0.7	1.7	-1.3
Ever smoked	1.4	2.4	3.4	1.8	-0.9	1.8
Unable to work because of sickness or disability	1.4	1.8	4.6	2.2	-0.1	0.8
Leg fat-free mass (left)	1.3	7.1	10.7	-2.1	-3.3	-2.4
Medication: Atenolol	1.3	1.6	2.2	-0.6	-1.5	-1.5
Hair/balding pattern: Pattern 2	1.3	1.6	2.3	0.9	1.3	1.5
Medication: Ramipril	1.3	1.7	3.6	1.9	1.0	0.6
Falls in the last year	1.3	1.7	2.2	1.2	1.5	1.3
Lung cancer (father)	1.3	1.5	3.5	0.9	-1.9	-0.6
Medication: Blood pressure	1.3	2.2	5.3	-0.9	-0.8	-2.3
Financial situation satisfaction	1.3	1.6	2.4	1.1	-1.5	-1.1
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.8	-0.7	-0.4	-2.0
Eye problems/disorders: Glaucoma	1.3	1.5	2.8	1.3	1.7	0.1
Leg predicted mass (left)	1.2	6.5	10.1	-2.0	-3.2	-2.3
Forced vital capacity (FVC), Best measure	1.2	4.5	9.6	-0.8	3.1	1.8
Neck or shoulder pain in last month	1.2	1.6	3.0	1.7	-1.4	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.2	0.2	1.5	-1.4
Hypertension (Self-reported)	1.2	3.3	6.0	2.5	1.9	0.2
Wears glasses or contact lenses	1.2	1.4	2.6	-1.6	-0.5	-1.1
Height	1.1	20.4	46.4	-6.8	3.2	2.2
Lung FVC	1.1	5.4	12.0	1.1	3.5	1.7
Neuroticism	1.1	2.5	4.2	2.1	-1.7	-0.8
Chronotype (morning person)	1.1	2.6	5.2	-1.4	2.3	-0.7
Systolic blood pressure, automated reading	1.1	3.3	3.6	1.8	-1.9	-1.8
Hearing difficulty/problems with background noise	1.1	1.8	4.0	0.3	1.2	2.0
Forced vital capacity (FVC)	1.1	4.1	9.4	-0.7	3.1	1.6
Number of children fathered	1.1	1.2	3.3	-0.0	-1.8	-0.5
Pulse wave peak to peak time	1.1	1.3	2.7	1.6	0.8	0.7
Medication: Omeprazole	1.1	1.4	3.4	0.6	-1.8	-0.6
Family relationship satisfaction	1.1	1.4	2.1	1.4	-0.2	1.4
Friendships satisfaction	1.1	1.4	2.5	1.1	0.7	1.6
Back pain experienced in last month	1.1	1.7	3.2	-0.1	-1.8	-1.3
Mother’s age at death	1.1	1.4	3.7	-1.9	0.3	-0.6
Systolic Blood Pressure	1.0	5.0	12.7	0.7	-1.3	-3.6
Diabetes (father)	1.0	1.2	2.0	-0.5	1.4	-1.2
Number of incorrect matches in round	1.0	1.7	3.7	1.1	-1.9	0.1
Medication: Amlodipine	1.0	1.3	3.2	-0.7	0.6	-1.8
Illnesses of siblings: Diabetes	1.0	1.2	3.3	1.8	0.0	0.5
Long-standing illness, disability or infirmity	1.0	1.5	3.5	0.9	1.9	-0.0
Alzheimer’s Disease (in father)	0.9	1.0	2.1	-0.9	-0.4	-1.4
Ovarian Cancer	0.9	1.2	2.2	1.0	-1.5	0.7
Rheumatoid Arthritis	0.9	1.2	2.0	1.4	1.1	0.6
Blood White Count	0.9	6.5	15.6	-1.1	-4.0	-1.6
High blood pressure	0.9	2.5	5.1	2.2	1.5	0.2
Impedance of leg (left)	0.9	4.5	7.3	-2.7	2.3	-1.0
Standing height	0.9	9.2	18.5	-4.3	2.6	1.5
Length of working week for main job	0.9	1.0	1.2	1.0	1.0	-1.1
Breastfed as a baby	0.9	1.1	2.6	-0.8	-0.4	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	2.0	1.4	-0.9	1.1
Birth weight of first child	0.9	1.7	3.6	0.2	1.2	1.9
Ever highly irritable/argumentative for 2 days	0.9	1.0	1.2	1.1	-1.0	-1.0
Chronic bronchitis/emphysema (mother)	0.9	1.0	1.5	-0.1	-1.2	-1.2
Migraine (self-reported)	0.9	1.1	2.1	0.5	1.4	0.9
Leg predicted mass (right)	0.9	4.6	7.2	-1.7	-2.7	-1.9
Ever taken oral contraceptive pill	0.9	1.0	1.6	1.2	-0.5	1.1
Basal metabolic rate	0.9	4.7	7.9	-1.2	-2.8	-2.2
Heart disease (siblings)	0.9	1.1	3.3	1.8	-0.2	-0.1
Bipolar Disorder (2018)	0.8	1.2	2.3	1.1	0.2	1.5
Medication for hormone replacement therapy	0.8	0.9	1.6	-1.0	-1.3	-0.2
Impedance of leg (right)	0.8	4.1	7.2	-2.7	2.1	-0.8
Heart attack	0.8	1.0	1.9	0.7	-0.8	-1.4
Neuroticism score	0.8	1.7	2.4	1.6	-1.4	-0.9
Noisy workplace	0.8	1.0	1.9	0.7	-1.4	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.7	1.3	-0.6	0.9
Shortness of breath walking on level ground	0.8	1.0	1.8	-0.3	-1.3	-1.0
Eye problems/disorders: None of the above	0.8	0.9	2.7	-0.3	-1.6	0.3
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.2	-0.8	-0.1	-1.5
Knee pain experienced in last month	0.8	1.2	2.1	1.0	-1.4	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.2	-0.5	-1.5	-0.7
Leg fat-free mass (right)	0.8	4.5	7.3	-1.6	-2.7	-1.9
Commuting to job workplace: Walk	0.8	0.9	2.1	0.6	1.4	0.5
Eye problems/disorders: Cataract	0.8	0.9	1.4	1.1	1.2	0.2
Breast cancer (self-reported)	0.8	1.0	1.7	-1.0	-1.3	-0.5
Medication: Blood pressure	0.8	1.6	3.4	1.0	1.8	-0.6
High cholesterol (Self-reported)	0.8	1.4	2.4	-1.2	0.6	-1.6
Alcohol drinker status: Never	0.8	1.0	1.8	-0.8	0.7	-1.4
Neuroticism (Nagel 2018)	0.7	1.7	3.9	2.0	-1.1	-0.3
Body Mass Index (BMI) (2010)	0.7	0.9	1.9	-0.6	-0.7	-1.4
LDL Cholesterol	0.7	1.1	1.9	-1.1	-0.4	-1.4
Blood Platelet Count	0.7	7.7	19.2	0.1	4.4	2.0
Cardiovascular Disease	0.7	2.2	5.1	1.2	0.4	-2.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.9	1.4	-1.0	0.5
Average weekly fortified wine intake	0.7	0.8	1.9	-0.6	-1.4	-0.4
Multivitamins +/- minerals	0.7	0.9	1.5	1.2	-0.8	0.9
Stomach or abdominal pain in last month	0.7	0.9	1.7	1.3	-1.0	0.1
Past tobacco smoking	0.7	1.2	2.1	-1.4	0.6	-1.1
Health satisfaction	0.7	0.9	1.4	-0.1	-1.2	-1.2
Medication: Aspirin	0.7	1.0	2.1	0.3	1.5	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	3.4	0.2	1.9	0.2
Medication: Aspirin	0.7	0.9	2.3	0.1	1.5	-0.6
Number of self-reported non-cancer illnesses	0.7	1.2	3.0	1.7	-0.5	0.6
Medication: Atorvastatin	0.7	0.9	1.9	-0.5	0.7	-1.4
Commuting to job workplace: Cycle	0.7	0.9	1.5	-1.2	0.6	0.9
Vascular/heart problems diagnosed by doctor	0.7	1.9	4.0	-2.0	-1.1	0.6
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.7	0.6	-0.9	-1.3
Angina	0.6	0.8	1.4	-0.9	0.2	-1.2
Medication: Simvastatin	0.6	0.9	1.0	-1.0	0.8	-1.0
Arm predicted mass (right)	0.6	3.1	5.8	-0.5	-2.4	-1.8
Comparative height size at age 10	0.6	3.2	5.1	-2.2	1.8	1.2
Illnesses of father: Heart disease	0.6	0.8	1.8	1.3	0.6	0.5
Medication for cholesterol	0.6	0.9	2.1	0.7	0.3	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.9	1.4	-0.2	0.3
Myopia	0.6	0.8	2.0	0.4	0.6	1.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.2	1.0	-1.1	0.2
Arm predicted mass (left)	0.6	2.9	5.6	0.1	-2.4	-1.8
HbA1C	0.5	0.5	1.5	-0.2	1.2	0.1
Hearing difficulty/problems: Yes	0.5	0.7	1.4	-1.2	0.1	-0.9
Arm fat-free mass (right)	0.5	2.6	4.8	-0.3	-2.2	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.5	-1.2	0.6	0.0
Medication for pain relief, constipation, heartburn	0.5	0.8	2.0	-1.4	0.4	0.4
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.2	0.2	-1.1	-0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.6	-1.3	-0.1	-0.1
Asthma (self-reported)	0.5	1.0	1.8	-1.3	-1.0	-0.4
Arm fat-free mass (left)	0.5	2.7	5.7	0.4	-2.4	-1.5
Depression (Nagel 2018)	0.4	0.6	1.0	1.0	-0.9	-0.1
Schizophrenia vs Biploar Disorder	0.4	0.6	1.6	0.0	1.3	0.3
Alzheimer’s Disease (including proxy)	0.4	0.6	1.0	-1.0	-0.8	-0.4
Chronic bronchitis/emphysema (father)	0.4	0.5	0.7	0.0	-0.8	0.8
Alcohol usually taken with meals	0.4	0.7	1.2	-0.9	1.1	0.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	0.4	-0.7	0.9
Worrier / anxious feelings	0.4	0.8	1.2	0.6	-1.0	-1.1
Asthma	0.4	0.8	1.6	-1.3	-0.9	-0.4
Angina (self-reported)	0.4	0.5	0.9	-0.6	0.5	-1.0
Supplements: Vitamin C	0.4	0.4	0.6	-0.7	-0.8	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.6	-0.5	1.3	0.9
Mineral and other dietary supplements	0.4	0.6	1.1	-0.8	0.2	-1.0
Commuting to job workplace: Public transport	0.4	0.4	1.1	-1.0	-0.3	0.3
Alcohol drinker status: Previous	0.4	0.5	1.0	0.5	-1.0	-0.5
Lung FEV1/FVC ratio	0.3	1.3	2.8	-1.0	1.7	0.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.3	-0.5	0.5	-0.6
Hayfever, allergic rhinitis or eczema	0.3	0.7	0.9	-0.9	-0.8	0.7
Mouth/teeth dental problems	0.3	0.4	1.0	0.2	-0.4	1.0
Allergy	0.3	0.6	0.7	0.8	0.8	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.4	0.6	-0.6	-0.6
High blood pressure (siblings)	0.3	0.5	1.1	1.1	0.5	-0.3
Emphysema/chronic bronchitis	0.3	0.4	0.7	0.9	0.3	0.5
Medication: Ibuprofen	0.3	0.3	0.5	0.7	-0.5	-0.5
Whole body fat-free mass	0.3	1.6	3.7	-0.4	-1.9	-0.9
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.8	-0.1	0.9	-0.3
Illnesses of father: None of the above (group 1)	0.3	0.4	0.8	-0.9	-0.5	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.4	-0.7	1.2	-0.4
Whole body water mass	0.3	1.6	3.8	-0.3	-1.9	-0.9
Hearing aid user	0.3	0.3	0.5	-0.6	0.7	-0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.2	-0.3	-1.1	-0.1
Cholesterol lowering medication	0.3	0.4	1.1	0.3	1.0	-0.3
Worry (Nagel 2018)	0.2	0.4	0.8	0.9	-0.1	-0.5
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	-0.7	-0.2	0.1
Mean Putamen Volume	0.2	0.2	0.6	-0.3	0.7	0.1
Allergy or Eczema	0.2	0.5	0.7	-0.8	-0.8	0.4
Tanning	0.2	2.5	4.5	-0.7	-2.1	-1.6
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	-0.6	-0.1	0.6
Maternal smoking around birth	0.2	0.4	0.8	0.9	-0.4	-0.3
Supplements: Glucosamine	0.2	0.3	0.9	-0.0	-0.9	0.0
Nervous feelings	0.2	0.4	1.2	0.1	1.1	-0.1
Birth weight	0.2	0.4	0.7	0.1	-0.8	0.8
Comparative body size at age 10	0.2	0.7	1.3	0.5	-1.1	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	0.6	-0.5	0.1
Medication: Bendroflumethiazide	0.2	0.3	0.6	0.1	0.8	-0.6
Risk taking	0.2	0.3	0.5	0.7	-0.3	0.4
Respiratory disease	0.1	0.2	0.5	-0.1	-0.1	0.7
Hair Pigment	0.1	4.0	6.6	2.3	0.2	2.6
Trunk fat-free mass	0.1	0.5	0.9	0.7	-1.0	0.3
Time employed in main current job	0.1	0.1	0.4	0.1	0.6	-0.2
Trunk predicted mass	0.1	0.4	0.7	0.7	-0.8	0.2
Headache pain in last month	0.1	0.2	0.3	0.4	-0.5	-0.0
Heart disease (mother)	0.1	0.1	0.1	0.4	-0.3	-0.1
Suffer from ‘nerves’	0.1	0.1	0.2	0.4	-0.2	-0.4
Average weekly red wine intake	0.1	0.2	0.5	-0.7	-0.2	0.2
Medication: Gliclazide	0.1	0.1	0.4	-0.1	0.6	-0.2
Medication: Lisinopril	0.1	0.2	0.4	0.2	0.7	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	0.6	0.3	0.2
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	-0.2	-0.1	-0.1
Blood clot in the leg (DVT)	0.0	0.0	0.1	0.3	0.2	0.1
Smoking status: Previous	0.0	0.1	0.1	0.2	-0.3	0.2
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.1	0.1	0.0	-0.3

Hub : Genes

RHOA-IT1

Models

Trait associations