TWAS hub - GAL

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.2067	0.0429	8.3e-16	0.168	0.152	0.170	0.172	0.168	5.2e-21	4.2e-19	2.5e-21	1.5e-21	4.2e-21
2	TCGA	Breast Invasive Carcinoma	0.0749	0.0347	1.5e-03	0.011	0.008	0.010	NA	0.006	2.0e-03	7.9e-03	3.7e-03	NA	1.8e-02
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1680	0.0780	3.1e-04	0.103	0.049	0.081	NA	0.095	1.6e-06	8.8e-04	2.1e-05	NA	4.5e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Heel bone mineral density (BMD) T-score, automated (right)	10.3	23.5	58.7	-7.7	2.9	1.8
Heel T-Score	9.9	78.9	219.0	-14.8	3.9	1.7
Osteoporosis (self-reported)	8.4	10.4	27.1	5.2	-1.5	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	7.2	16.2	44.1	-6.6	1.8	1.2
Leg predicted mass (right)	4.1	21.8	54.2	-7.4	1.9	2.8
Trunk predicted mass	4.0	22.6	60.4	-7.8	1.0	2.6
Whole body water mass	4.0	23.1	59.4	-7.7	1.4	2.8
Whole body fat-free mass	3.9	22.2	57.9	-7.6	1.3	2.7
Leg fat-free mass (right)	3.9	20.7	51.8	-7.2	1.8	2.7
Trunk fat-free mass	3.8	22.0	59.0	-7.7	0.9	2.5
Arm fat-free mass (right)	3.8	19.3	50.1	-7.1	1.1	2.5
Arm predicted mass (right)	3.7	19.1	47.9	-6.9	1.2	2.9
Leg fat-free mass (left)	3.6	19.0	48.6	-7.0	1.5	2.5
Leg predicted mass (left)	3.5	18.7	48.4	-7.0	1.4	2.4
Basal metabolic rate	3.5	19.4	50.3	-7.1	1.3	2.5
Arm predicted mass (left)	3.4	17.3	44.1	-6.6	1.1	2.5
Supplements: Zinc	3.3	3.6	4.2	-2.0	1.9	1.8
Arm fat-free mass (left)	3.2	16.4	43.2	-6.6	1.0	2.2
Schizophrenia (2018)	3.1	6.5	7.9	-2.6	2.2	2.8
Supplements: Glucosamine	3.0	3.9	6.5	-2.1	0.7	2.6
Schizophrenia (2014)	2.8	6.1	9.1	-2.4	1.8	3.0
Impedance of leg (right)	2.7	13.2	23.7	4.9	-2.1	-3.4
Had major operations	2.7	3.2	8.6	0.6	0.7	2.9
Height	2.6	49.7	139.2	-11.8	2.5	1.9
Number of children fathered	2.6	2.9	4.4	-2.1	2.1	-0.1
Townsend deprivation index at recruitment	2.5	3.6	6.1	-0.6	2.5	2.0
Forced expiratory volume in 1-second (FEV1)	2.5	8.4	25.3	-5.0	0.1	-0.1
Comparative height size at age 10	2.5	13.6	39.7	-6.3	0.6	0.8
Average weekly champagne plus white wine intake	2.5	3.5	7.6	-2.8	1.2	1.2
Schizophrenia vs Biploar Disorder	2.4	3.2	8.0	-2.8	0.1	1.2
Smoking Status	2.4	5.8	6.6	-2.2	2.5	2.6
Forced vital capacity (FVC)	2.4	9.1	26.9	-5.2	-0.0	-0.5
Standing height	2.4	24.0	70.4	-8.4	1.0	0.7
Impedance of leg (left)	2.3	11.1	21.2	4.6	-1.6	-3.1
Past tobacco smoking	2.3	4.3	5.9	2.4	-2.2	-1.4
Medication: Cholesterol lowering	2.2	3.4	5.6	2.4	-1.8	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	3.6	-1.2	1.9	1.4
Risk taking	2.2	3.2	4.2	-2.0	1.4	1.8
Peak expiratory flow (PEF)	2.1	5.0	14.6	-3.8	0.5	0.3
Bipolar Disorder or Schizophrenia	2.0	4.8	8.9	-1.3	2.0	3.0
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	3.3	-1.1	1.8	1.6
Loud music exposure frequency	2.0	2.2	3.3	0.7	1.8	1.6
Triglycerides	1.9	3.0	4.6	2.1	-0.4	-2.1
Weight	1.9	9.3	23.9	-4.9	0.8	1.8
Ever highly irritable/argumentative for 2 days	1.9	2.3	5.3	-0.4	2.3	1.2
Handedness (chirality/laterality): Left-handed	1.9	2.3	5.3	-1.0	-0.8	-2.3
Basal cell carcinoma (self-reported)	1.9	2.3	5.3	-2.3	0.4	1.2
Mouth/teeth dental problems	1.8	2.8	5.6	0.4	-2.4	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.6	16.8	-4.1	-0.3	0.0
Smoking status: Current	1.8	2.8	4.1	-2.0	1.7	1.2
Average weekly beer plus cider intake	1.8	2.5	5.5	-2.3	1.3	0.6
Forced vital capacity (FVC), Best measure	1.7	6.3	18.6	-4.3	-0.5	-0.3
Diabetes diagnosed by doctor	1.7	2.8	5.5	2.3	-1.3	-1.1
Ever smoked	1.7	3.0	4.8	-2.2	1.1	1.7
LDL Cholesterol	1.6	2.6	3.4	1.6	-1.4	-1.9
Medication for hormone replacement therapy	1.6	1.8	3.2	0.1	1.8	1.4
Sitting height	1.6	11.2	32.4	-5.7	0.1	1.1
Time employed in main current job	1.6	1.8	3.8	1.9	-1.0	-0.8
Breastfed as a baby	1.6	2.0	4.9	-0.2	1.0	2.2
Birth weight of first child	1.6	3.0	4.4	-1.5	-2.1	-1.5
Headache pain in last month	1.6	2.8	6.9	2.6	-1.2	-0.4
Chronic bronchitis/emphysema (mother)	1.6	1.8	3.2	1.5	-0.4	-1.8
Worry too long after embarrassment	1.5	2.6	4.5	2.1	-1.8	-0.1
Eye problems/disorders: Cataract	1.5	1.8	5.1	-0.2	-0.4	-2.3
Impedance of whole body	1.5	7.7	15.8	4.0	-0.8	-2.6
Current tobacco smoking	1.4	2.4	3.4	-1.9	1.2	1.4
Falls in the last year	1.4	1.9	3.2	1.2	1.0	1.8
Length of working week for main job	1.4	1.5	3.5	-1.0	1.9	0.0
Glaucoma (self-reported)	1.4	1.6	3.6	-0.2	1.9	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	3.2	-1.2	1.8	0.5
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	2.9	-1.7	1.6	0.9
Shortness of breath walking on level ground	1.3	1.6	2.5	1.3	-1.6	-0.7
Eye problems/disorders: None of the above	1.3	1.6	2.9	1.3	-1.7	-0.4
Eye problems/disorders: Glaucoma	1.3	1.6	3.7	0.1	1.9	1.0
Ever depressed for a whole week	1.3	1.7	2.4	0.7	1.4	1.5
Myopia	1.3	1.9	5.5	-2.3	-0.2	0.4
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	3.0	0.2	-1.4	-1.7
Hair Pigment	1.2	33.5	55.5	-7.5	4.9	4.5
Maternal smoking around birth	1.2	1.7	3.6	-1.9	1.2	0.4
Noisy workplace	1.2	1.5	4.1	2.0	0.4	0.6
Prospective memory result	1.2	1.5	2.3	1.5	-1.1	-1.0
High blood pressure (siblings)	1.2	1.7	2.7	0.6	-1.5	-1.6
Health satisfaction	1.2	1.5	2.2	1.4	-0.7	-1.5
Medication: Blood pressure	1.2	2.2	2.5	1.3	-1.6	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	7.2	-2.7	-0.4	-0.1
Medication: Aspirin	1.2	1.5	2.4	-0.7	-1.3	-1.6
Alcohol drinker status: Never	1.2	1.4	3.2	1.0	-1.8	-0.3
Crohns Disease (2012)	1.1	1.7	3.3	-0.4	1.3	-1.8
Hypothyroidism (self reported)	1.1	2.4	3.5	1.7	-0.9	-1.9
Hair/balding pattern: Pattern 2	1.1	1.4	1.8	-1.2	-1.0	-1.3
Had menopause	1.1	1.4	3.1	-0.4	-1.8	-0.9
Impedance of arm (right)	1.1	5.4	10.3	3.2	-0.7	-2.3
Blood clot in the leg (DVT)	1.1	1.4	2.5	-0.1	-1.3	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.0	0.9	-1.4	-1.0
Suffer from ‘nerves’	1.1	1.7	2.2	1.1	-1.5	-1.4
Smoking status: Previous	1.1	1.6	2.5	-1.6	1.2	1.0
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	4.1	-0.9	2.0	0.4
Osteoarthritis (self-reported)	1.1	1.5	2.9	-1.1	0.5	1.7
Medication: Gliclazide	1.1	1.2	2.1	1.5	0.4	-1.2
Medication: Lisinopril	1.1	1.4	2.5	1.0	-0.8	-1.6
Fractured/broken bones in last 5 years	1.1	1.4	3.5	1.9	0.5	-0.7
Nervous feelings	1.0	1.9	3.7	1.9	-0.9	-1.1
Fluid intelligence score	1.0	2.0	3.0	-1.7	1.0	1.4
Mouth/teeth dental problems: Dentures	1.0	1.7	3.5	-0.0	1.3	1.9
Medication: Ibuprofen	1.0	1.2	1.7	0.4	1.3	1.3
Medication: Aspirin	1.0	1.3	1.5	-1.0	-1.1	-1.2
Supplements: Vitamin C	1.0	1.2	2.4	-1.6	1.0	0.4
Medication: Paracetamol	1.0	1.6	2.6	1.6	-1.1	-1.0
Heart disease (siblings)	1.0	1.2	3.1	-0.7	0.3	1.8
Body Mass Index (BMI) (2010)	0.9	1.2	2.7	-1.0	1.6	0.2
Average weekly fortified wine intake	0.9	1.0	2.2	1.5	0.3	-0.8
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.4	-0.6	1.6	0.7
Had other major operations	0.9	1.1	2.2	1.5	-0.6	-0.8
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.2	1.8	0.1	-0.3
Diabetes (self-reported)	0.9	1.4	3.8	1.9	-0.6	-0.3
Comparative body size at age 10	0.9	2.6	4.2	-2.0	-1.2	1.4
Supplements: Fish oil (including cod liver oil)	0.9	1.1	2.1	-1.5	-0.9	-0.7
Medication: Bendroflumethiazide	0.9	1.3	3.4	0.8	-0.0	-1.8
Bipolar Disorder (2011)	0.8	0.8	2.3	1.5	0.4	0.0
Fasting Glucose	0.8	0.9	2.0	-1.4	0.8	0.3
HbA1C	0.8	0.9	2.4	-1.6	0.6	0.0
Medication: Simvastatin	0.8	1.1	2.8	1.7	-0.7	0.4
Alcohol intake versus 10 years previously	0.8	1.3	2.3	1.5	-1.0	0.7
Medication: Amlodipine	0.8	1.2	2.2	-0.7	-0.9	-1.5
Leg pain on walking	0.8	1.0	1.8	0.8	-1.3	0.7
Average weekly red wine intake	0.8	1.2	2.8	-0.1	1.7	0.8
Medication: Blood pressure	0.8	1.5	3.0	1.2	0.2	-1.7
Pain experienced in last month	0.8	1.3	3.7	0.1	0.2	-1.9
Bipolar Disorder (2018)	0.7	1.0	1.6	1.2	0.3	1.3
Intelligence (Savage-Jansen 2018)	0.7	2.3	3.3	-1.4	1.2	1.8
Primary Biliary Cirrhosis	0.7	0.9	2.1	1.5	0.6	0.6
BMI	0.7	3.8	7.6	-2.8	0.4	1.9
Angina	0.7	0.9	1.2	1.1	-1.1	-0.7
Taking other prescription medications	0.7	1.0	2.4	1.5	-0.7	-0.5
Impedance of arm (left)	0.7	3.3	7.0	2.6	0.2	-1.7
Exposure to tobacco smoke outside home	0.7	0.9	2.0	-1.4	0.9	-0.1
Pulse rate, automated reading	0.7	2.3	5.7	-2.4	0.6	0.9
Mineral and other dietary supplements	0.7	0.9	2.2	1.5	0.7	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	3.7	-1.9	-0.4	0.9
Hearing aid user	0.7	0.8	1.8	-0.7	1.3	0.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.5	-0.8	0.6	-1.2
Age started oral contraceptive pill	0.7	0.9	1.3	1.1	-1.1	0.3
Unable to work because of sickness or disability	0.7	0.9	2.0	0.8	-1.4	-0.4
Worry (Nagel 2018)	0.6	1.2	1.6	1.3	-1.3	-0.5
Major Depression (MDD)	0.6	0.7	1.7	-0.5	0.3	1.3
Age at First Birth	0.6	0.8	1.5	-1.0	-1.2	-0.1
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.5	1.2	-1.2	-0.5
Hand grip strength (left)	0.6	1.5	4.6	-2.1	-0.1	-0.2
Ever had hysterectomy (womb removed)	0.6	0.7	1.5	-1.2	0.4	0.5
Medication: Co-codamol	0.6	0.7	1.7	-1.3	0.2	0.7
Hand grip strength (right)	0.6	1.7	4.7	-2.2	0.5	-0.4
Qualifications: CSEs or equivalent	0.6	0.9	1.7	-0.9	-0.1	-1.3
Number of live births	0.6	0.8	1.4	1.0	-0.0	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.2	-0.1	1.1	1.0
Leg fat percentage (right)	0.6	2.1	4.7	2.2	-1.1	-0.6
Neck or shoulder pain in last month	0.6	0.9	2.0	-1.4	0.7	0.4
Illnesses of father: Heart disease	0.6	0.8	1.4	1.2	-0.4	0.8
Medication for cholesterol	0.6	0.9	1.3	-1.2	-0.9	0.7
Mother’s age at death	0.6	0.7	1.2	-1.1	-0.9	-0.1
Commuting to job workplace: Cycle	0.6	0.8	2.2	-1.5	0.3	0.0
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.2	-1.5	1.0	0.7
Prostate Cancer	0.5	0.7	1.9	-0.3	-0.3	-1.4
Blood Eosinophil Count	0.5	3.8	10.6	-3.3	0.2	0.8
Respiratory disease	0.5	1.0	1.8	-1.1	0.3	-1.3
Chronotype (morning person)	0.5	1.2	2.9	0.3	-1.7	-0.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.0	1.0	-0.6	-0.9
Serious illness, injury or assault to yourself	0.5	0.6	1.3	0.5	-0.6	1.1
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.0	-1.4	0.9	-0.5
Allergy	0.5	1.2	2.7	1.6	-0.6	0.7
Father’s age at death	0.5	0.7	1.3	-1.1	0.2	-0.9
Asthma	0.5	1.0	2.4	-0.1	-0.8	-1.6
Arm fat mass (right)	0.5	1.9	3.8	-1.9	0.6	1.2
Exposure to tobacco smoke at home	0.5	0.6	1.3	1.2	0.6	-0.2
Age at first live birth	0.5	0.8	2.1	-1.5	0.5	0.1
Angina (self-reported)	0.5	0.7	0.9	1.0	-0.9	-0.7
Alcohol intake frequency.	0.5	1.2	3.0	1.7	-0.7	-0.3
Age at last live birth	0.5	0.8	1.5	0.5	-1.2	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.5	0.6	0.8	0.8	-0.7
Knee pain experienced in last month	0.5	0.8	1.8	-0.4	-0.8	1.3
Mood swings	0.5	0.9	1.7	-0.6	0.8	1.3
Loneliness, isolation	0.5	0.6	0.8	-0.9	0.7	0.8
Asthma (self-reported)	0.5	1.0	2.2	-0.0	-0.8	-1.5
Arm fat mass (left)	0.5	2.1	4.0	-2.0	0.6	1.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.6	1.3	-0.0	-0.5
Alzheimer’s Disease (in father)	0.4	0.4	0.8	-0.4	0.5	0.9
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.4	1.2	-0.3	0.1
Blood Platelet Count	0.4	4.4	6.5	1.2	-2.3	-2.5
Allergy or Eczema	0.4	1.0	2.0	-1.4	1.0	-0.2
Lung FVC	0.4	2.0	5.8	-2.4	-0.4	-0.2
Number of treatments/medications taken	0.4	0.7	1.6	0.7	-0.0	-1.3
Average weekly spirits intake	0.4	0.5	1.4	-0.5	0.0	1.2
Relative age of first facial hair	0.4	0.7	0.9	0.7	1.0	0.9
Severe depression (siblings)	0.4	0.5	0.8	0.6	-0.4	0.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.7	-0.8	0.8	-0.3
High blood pressure	0.4	1.1	2.6	0.9	-0.2	-1.6
Stomach or abdominal pain in last month	0.4	0.5	1.3	0.1	1.2	-0.2
Chronic bronchitis/emphysema (father)	0.4	0.4	0.9	1.0	0.6	-0.2
Body mass index (BMI)	0.4	1.5	2.5	-1.4	0.4	1.6
Hearing difficulty/problems with background noise	0.4	0.7	1.8	-1.3	-0.3	-0.4
Financial difficulties in last 2 years	0.4	0.5	1.1	0.4	0.6	1.0
Pain all over the body in last month	0.4	0.5	0.8	0.8	0.9	-0.2
Pulse rate	0.4	0.7	1.5	-0.6	1.2	0.3
Depression (self-reported)	0.4	0.5	1.4	-1.2	0.0	0.0
Illnesses of mother	0.4	0.5	1.3	0.1	1.1	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.5	-1.2	0.4	0.6
Gout (self-reported)	0.4	0.6	1.1	0.2	-0.7	-1.0
Birth weight	0.4	0.9	1.9	-1.4	-1.0	0.1
Number of full brothers	0.4	0.5	0.6	0.6	-0.8	0.8
Number of full sisters	0.4	0.4	0.9	0.0	0.6	0.9
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.5	0.1	-1.2	-0.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.8	-0.3	0.8	-0.9
Hypertension (Self-reported)	0.4	1.0	2.2	0.9	0.0	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	-0.5	0.3	1.1
Friendships satisfaction	0.4	0.5	1.0	-1.0	0.5	0.4
Commuting to job workplace: Walk	0.4	0.4	1.0	-0.5	1.0	0.3
Wears glasses or contact lenses	0.4	0.5	0.7	0.3	-0.9	0.8
Ever taken oral contraceptive pill	0.4	0.4	0.7	0.9	-0.8	0.0
High cholesterol (Self-reported)	0.4	0.6	1.5	1.2	-0.7	0.0
Medication: Atorvastatin	0.4	0.5	1.0	0.4	-0.6	-1.0
Leg fat percentage (left)	0.4	1.3	3.3	1.8	-0.7	-0.3
Cholesterol lowering medication	0.4	0.6	1.0	0.0	1.0	1.0
Depressed Affect (Nagel 2018)	0.3	0.6	1.6	0.3	0.3	1.3
Crohns Disease (2017)	0.3	0.6	1.1	-1.1	0.2	-0.8
Irritable Bowel Disease (IBD)	0.3	0.7	1.4	-0.2	-0.8	-1.2
Ovarian Cancer	0.3	0.4	0.9	1.0	0.4	0.2
Rheumatoid Arthritis	0.3	0.4	0.9	0.2	0.3	1.0
Blood Red Count	0.3	2.9	4.8	-1.6	-1.2	-2.2
Systolic Blood Pressure	0.3	1.7	3.1	1.8	0.7	-1.2
Sensitivity / hurt feelings	0.3	0.6	1.7	0.0	-1.3	0.2
Hearing difficulty/problems: Yes	0.3	0.5	1.1	-0.5	1.0	-0.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	-0.4	0.1	0.9
Vitamin and mineral supplements	0.3	0.3	0.8	0.9	-0.5	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	0.8	0.3	0.7	0.9
Medication: Levothyroxine sodium	0.3	0.5	1.0	1.0	-0.6	-0.0
Trunk fat mass	0.3	1.3	2.9	-1.7	0.2	1.0
Waist circumference	0.3	1.0	1.7	-1.1	-0.0	1.3
Illnesses of siblings	0.3	0.5	0.9	0.9	-0.0	-0.7
Worrier / anxious feelings	0.3	0.6	1.7	1.3	0.2	0.3
Lung cancer (father)	0.3	0.4	0.6	0.5	0.6	-0.8
Pulse wave reflection index	0.3	0.4	0.5	-0.7	0.5	0.6
Medication: Paracetamol	0.3	0.6	0.9	1.0	-0.6	-0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.3	1.1	-0.0	-0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.1	-1.0	-0.2	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.5	-0.6	-0.7	-0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	0.4	0.9	0.3
Emphysema/chronic bronchitis	0.3	0.4	0.7	-0.8	0.4	0.5
Migraine (self-reported)	0.3	0.4	0.6	0.8	0.7	-0.4
Heart disease (mother)	0.3	0.4	1.0	0.4	-1.0	0.1
Chest pain or discomfort	0.3	0.4	0.7	0.9	0.3	-0.6
Illnesses of siblings: Diabetes	0.3	0.4	1.1	-1.1	-0.2	-0.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.0	0.2	-1.0	-0.5
Illnesses of father: High blood pressure	0.3	0.4	0.6	-0.0	-0.8	-0.7
Number of operations (self-reported)	0.3	0.5	1.0	0.2	1.0	-0.7
Irritability	0.3	0.6	1.3	-0.7	0.2	1.1
Depression (Nagel 2018)	0.2	0.2	0.4	0.6	-0.3	0.5
Neuroticism (Nagel 2018)	0.2	0.6	0.9	0.9	-0.8	0.5
Breast Cancer	0.2	0.4	0.9	0.2	1.0	0.5
HDL Cholesterol	0.2	0.4	0.5	-0.7	-0.6	-0.4
Waist Hip Ratio (WHR)	0.2	0.8	1.5	0.8	-0.3	-1.2
Lung FEV1/FVC ratio	0.2	1.2	3.3	-1.8	0.5	0.4
Tanning	0.2	2.1	2.7	1.4	-1.6	-1.3
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	-0.6	0.7	-0.4
Systolic blood pressure, automated reading	0.2	0.5	0.8	0.9	0.8	-0.1
Medication: Metformin	0.2	0.2	0.3	0.4	-0.5	0.6
Relative age voice broke	0.2	0.3	0.8	-0.3	0.9	0.1
Age when periods started (menarche)	0.2	0.5	0.7	0.8	0.2	-0.8
Multivitamins +/- minerals	0.2	0.2	0.6	-0.8	-0.2	-0.2
Medication: Atenolol	0.2	0.3	0.5	-0.1	-0.7	-0.5
High blood pressure (mother)	0.2	0.2	0.5	-0.2	-0.7	0.3
Number of incorrect matches in round	0.2	0.4	0.8	-0.3	-0.6	0.9
Alcohol usually taken with meals	0.2	0.3	0.8	0.1	0.0	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	0.8	-0.4	0.4
Qualifications: None of the above	0.2	0.4	1.1	0.1	0.1	-1.1
Heart attack	0.2	0.2	0.4	-0.7	0.2	-0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	0.1	0.8	-0.5
Hip circumference	0.2	1.1	1.6	-1.3	-0.3	1.2
Hair/balding pattern: Pattern 3	0.2	0.2	0.4	-0.0	0.6	0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	0.7	0.1	-0.5
Medication: Omeprazole	0.2	0.2	0.6	0.8	0.3	-0.1
Medication: Seretide 50 evohaler	0.2	0.2	0.4	-0.6	-0.1	-0.4
Mean time to correctly identify matches	0.2	0.3	0.7	-0.3	0.4	0.9
Whole body fat mass	0.2	0.9	2.0	-1.4	-0.0	0.8
Leg fat mass (right)	0.2	0.6	1.3	-1.1	-0.5	0.6
Back pain experienced in last month	0.2	0.2	0.4	-0.3	-0.6	0.5
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.4	0.6	-0.3
Miserableness	0.2	0.3	0.5	0.1	0.7	0.6
Guilty feelings	0.2	0.4	0.7	0.4	-0.8	-0.5
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	0.3	-0.1	0.8
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.0	-0.9	0.4	1.0
Leg fat mass (left)	0.2	0.8	1.8	-1.3	-0.3	0.7
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.2	-0.4	-0.4
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	-0.6	0.4	0.3
Ulcerative Colitis (UC)	0.1	0.3	0.5	0.0	-0.6	-0.7
Coronary Artery Disease (CAD)	0.1	0.1	0.1	0.3	0.4	-0.0
Mean Putamen Volume	0.1	0.1	0.2	0.4	0.1	-0.4
Lupus	0.1	0.1	0.4	0.1	-0.6	0.1
Neuroticism (2016)	0.1	0.1	0.1	-0.4	-0.2	-0.3
Ulcerative Colitis	0.1	0.2	0.4	-0.3	0.2	0.7
Cardiovascular Disease	0.1	0.2	0.5	0.7	-0.0	-0.2
Neuroticism	0.1	0.3	0.5	0.6	-0.1	0.7
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.4	-0.1	-0.6	-0.1
Diabetes (father)	0.1	0.1	0.1	0.3	0.3	-0.1
Diabetes (mother)	0.1	0.1	0.2	-0.5	-0.0	-0.3
Pack years adult smoking proportion	0.1	0.2	0.5	0.7	0.1	0.4
Medication: Ramipril	0.1	0.2	0.4	0.2	0.1	-0.6
Neuroticism score	0.1	0.2	0.4	0.5	-0.2	0.6
Arm fat percentage (right)	0.1	0.3	0.8	0.9	0.1	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.3	0.6	0.1
Happiness	0.1	0.1	0.4	-0.2	0.0	-0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	-0.2	0.5	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	-0.3	-0.0	0.5
Medication: Lansoprazole	0.1	0.2	0.5	-0.0	-0.7	0.1
Tense / ‘highly strung’	0.1	0.2	0.4	0.5	-0.6	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	0.4	-0.0	-0.6
Body fat percentage	0.1	0.4	1.1	1.1	-0.2	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.5	-0.2	0.1
Wheeze or whistling in the chest in last year	0.1	0.3	0.3	0.6	0.5	-0.5
Pulse wave peak to peak time	0.1	0.1	0.1	-0.3	-0.2	-0.3
Qualifications: College or University degree	0.1	0.3	0.8	0.1	-0.2	0.9
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	0.4	0.2	0.6
Medication: Allopurinol	0.1	0.2	0.6	0.7	-0.2	0.0
Overall health rating	0.1	0.3	0.6	0.8	-0.5	-0.3
Family relationship satisfaction	0.1	0.1	0.1	0.4	-0.1	-0.4
Arm fat percentage (left)	0.1	0.3	0.5	0.6	0.3	0.7
Long-standing illness, disability or infirmity	0.1	0.1	0.4	0.6	-0.1	-0.0
Ever had bowel cancer screening	0.1	0.1	0.2	0.4	0.3	0.4
Breast cancer (self-reported)	0.1	0.1	0.2	-0.5	-0.1	-0.3
Number of self-reported non-cancer illnesses	0.1	0.2	0.6	0.1	0.8	-0.3
Financial situation satisfaction	0.1	0.2	0.2	0.5	0.4	0.3
Diastolic blood pressure, automated reading	0.1	0.2	0.4	-0.0	0.5	0.7
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	-0.5	-0.1	-0.6
Pack years of smoking	0.1	0.2	0.2	0.4	0.2	0.5
Reaction Time	0.0	0.1	0.2	-0.2	0.1	0.5
Blood White Count	0.0	0.1	0.3	0.6	0.3	-0.1
Trunk fat percentage	0.0	0.1	0.1	0.3	0.0	0.3
Fed-up feelings	0.0	0.0	0.1	-0.0	0.3	0.2
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	-0.2	0.2	0.1
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.1	-0.2	0.5
Qualifications: nursing, teaching	0.0	0.1	0.2	-0.4	0.1	0.1
Commuting to job workplace: Public transport	0.0	0.1	0.1	-0.3	0.3	0.1
Supplements: Calcium	0.0	0.0	0.0	-0.0	-0.2	0.2
Alcohol drinker status: Previous	0.0	0.0	0.1	0.2	0.2	0.2

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