TWAS hub - MTL5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0490	0.0190	4.0e-04	0.024	0.037	0.039	0.046	0.036	5.6e-04	2.5e-05	1.3e-05	2.6e-06	2.8e-05
2	METSIM	Adipose	0.0683	0.0211	4.7e-07	0.036	0.036	0.020	0.037	0.027	3.3e-06	3.6e-06	4.1e-04	2.7e-06	5.7e-05
3	YFS	Blood	0.0481	0.0150	1.1e-09	0.032	0.034	0.026	0.033	0.027	1.3e-10	2.1e-11	3.7e-09	4.6e-11	2.2e-09
4	TCGA	Breast Invasive Carcinoma	0.0265	0.0158	2.0e-03	0.009	0.013	0.019	NA	0.013	4.0e-03	9.2e-04	7.1e-05	NA	7.2e-04
5	TCGA	Pheochromocytoma and Paraganglioma	0.0920	0.0700	9.3e-03	0.015	0.040	-0.005	NA	0.005	8.2e-02	1.0e-02	5.9e-01	NA	1.9e-01
6	TCGA	Prostate Adenocarcinoma	0.0444	0.0227	1.0e-04	0.017	0.032	0.018	NA	0.023	5.6e-03	2.4e-04	5.0e-03	NA	1.6e-03
7	TCGA	Thyroid Carcinoma	0.0210	0.0130	3.6e-03	0.012	0.023	0.011	NA	0.010	2.4e-02	2.2e-03	2.9e-02	NA	3.0e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Heel T-Score	8.8	70.0	179.6	13.4	6.8	11.0	0.7	10.0	1.3	6.4
Osteoporosis (self-reported)	7.9	9.8	18.9	-4.0	-2.4	-3.8	-1.1	-4.3	-1.3	-3.2
Heel bone mineral density (BMD) T-score, automated (right)	5.2	11.9	31.4	5.6	3.6	3.5	1.4	4.2	0.5	2.6
Forced vital capacity (FVC)	5.0	19.3	34.1	0.8	5.8	5.5	3.7	4.6	3.8	4.6
Heel bone mineral density (BMD) T-score, automated (left)	4.7	10.7	30.2	5.5	3.4	3.6	0.1	3.9	-0.2	2.2
Trunk predicted mass	4.6	26.4	51.4	2.0	6.3	7.2	4.4	5.9	3.2	5.0
Whole body water mass	4.6	26.1	48.9	2.1	6.8	7.0	4.0	5.9	2.9	4.8
Leg predicted mass (right)	4.6	24.8	48.9	2.2	7.0	6.7	3.6	5.7	2.7	4.7
Trunk fat-free mass	4.5	26.1	50.3	2.0	6.3	7.1	4.3	5.8	3.2	5.0
Alcohol intake versus 10 years previously	4.5	6.7	12.4	-2.2	-2.7	-3.5	-0.5	-2.8	-2.3	-3.0
Whole body fat-free mass	4.5	25.9	48.7	2.2	6.8	7.0	3.9	5.8	3.0	4.8
Leg fat-free mass (right)	4.5	24.3	48.6	2.2	7.0	6.6	3.5	5.7	2.7	4.6
Forced expiratory volume in 1-second (FEV1)	4.4	14.8	33.4	0.8	5.8	4.9	2.7	4.2	2.7	3.7
Had major operations	4.4	5.1	7.5	-1.2	-2.7	-2.0	-2.1	-2.1	-2.7	-2.5
Leg fat-free mass (left)	4.3	22.5	47.0	2.1	6.9	6.4	3.3	5.5	2.5	4.4
Leg predicted mass (left)	4.3	22.9	46.1	2.2	6.8	6.5	3.2	5.6	2.5	4.4
Eye problems/disorders: Cataract	4.3	4.9	9.6	2.4	3.1	1.8	0.8	2.1	2.2	2.4
Basal metabolic rate	4.2	23.2	43.8	1.9	6.6	6.5	3.7	5.5	2.9	4.6
Bipolar Disorder (2018)	4.0	6.4	12.4	-0.9	-2.6	-1.8	-3.5	-1.9	-3.2	-2.7
Arm fat-free mass (left)	3.9	19.8	37.9	1.9	6.0	6.2	3.4	5.1	2.5	4.2
Arm fat-free mass (right)	3.8	19.2	36.4	1.8	5.8	6.0	3.6	5.0	2.5	4.1
Arm predicted mass (left)	3.8	19.3	37.3	1.6	6.1	6.0	3.5	5.0	2.5	4.1
Standing height	3.7	36.3	58.8	0.7	4.8	7.7	6.8	6.8	5.8	6.8
Number of children fathered	3.7	4.2	6.7	2.6	0.8	1.5	1.4	2.6	2.2	2.5
Height	3.6	69.3	116.6	0.9	6.6	10.8	8.8	9.8	7.9	9.4
Serious illness, injury or assault to yourself	3.6	4.4	9.2	-0.8	-2.0	-1.3	-3.0	-1.1	-3.0	-2.2
Worry too long after embarrassment	3.4	5.8	9.5	-2.0	-2.5	-2.4	-1.3	-3.1	-2.2	-2.9
Forced vital capacity (FVC), Best measure	3.3	12.2	23.0	0.5	4.8	4.7	3.1	3.5	2.6	3.4
Forced expiratory volume in 1-second (FEV1), Best measure	3.1	9.8	24.3	0.6	4.9	4.3	2.1	3.2	1.7	2.7
Arm predicted mass (right)	3.1	16.0	32.5	1.3	5.4	5.7	3.3	4.6	2.0	3.6
Crohns Disease (2012)	3.0	4.8	8.2	2.9	1.0	2.4	1.0	2.5	2.3	2.7
Frequency of tenseness / restlessness in last 2 weeks	3.0	4.7	8.4	-2.2	-2.4	-2.0	-1.2	-2.9	-1.6	-2.5
Hand grip strength (right)	2.9	7.8	18.7	1.7	4.3	2.4	2.5	2.5	2.6	2.8
Worrier / anxious feelings	2.9	5.4	10.8	-1.1	-2.7	-3.3	-1.4	-2.6	-2.0	-2.5
Comparative height size at age 10	2.9	16.2	22.8	0.4	3.3	4.8	4.8	4.7	3.9	4.5
Body Mass Index (BMI) (2010)	2.8	3.8	9.4	-0.4	2.8	0.5	3.1	1.2	2.3	1.7
Hand grip strength (left)	2.8	7.4	19.0	1.7	4.4	2.7	2.4	2.5	2.1	2.6
Severe depression (siblings)	2.7	3.1	5.7	-1.5	-1.3	-1.0	-1.6	-1.9	-2.4	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.7	3.5	6.2	-0.7	-1.5	-2.0	-2.2	-1.5	-2.5	-2.1
Medication: Simvastatin	2.5	3.6	7.0	-1.8	-1.2	-2.7	-1.7	-2.2	-1.5	-1.9
Medication: Aspirin	2.5	3.3	8.8	1.6	1.1	3.0	0.9	2.3	1.2	1.8
Hayfever, allergic rhinitis or eczema	2.4	5.3	11.9	3.4	0.5	2.3	0.3	3.1	1.5	2.8
Sitting height	2.4	17.2	40.8	1.4	4.1	6.4	3.2	4.9	2.8	4.3
Falls in the last year	2.3	3.1	6.8	-0.8	-1.5	-2.6	-1.3	-1.6	-2.0	-1.9
Number of operations (self-reported)	2.3	3.4	11.4	3.4	-1.4	1.5	-2.0	1.7	-0.6	0.8
Impedance of leg (left)	2.2	10.5	27.4	-3.6	-5.2	-4.2	0.6	-3.4	1.1	-1.5
Weight	2.2	10.7	25.6	0.7	5.1	4.3	2.2	3.7	1.8	3.0
Peak expiratory flow (PEF)	2.2	5.2	15.9	0.4	4.0	2.9	1.4	2.3	1.1	1.9
Headache pain in last month	2.2	3.8	6.1	-1.6	-0.9	-1.3	-2.3	-2.5	-2.0	-2.5
Impedance of leg (right)	2.1	10.2	25.3	-3.6	-5.0	-4.2	0.1	-3.4	0.8	-1.8
Gout (self-reported)	2.1	2.9	5.8	1.0	1.4	1.2	2.3	1.1	2.4	1.8
Shortness of breath walking on level ground	2.1	2.5	4.7	-0.8	-1.1	-0.8	-2.2	-1.5	-2.1	-1.9
Bipolar Disorder or Schizophrenia	2.0	4.9	8.6	0.0	-2.9	-2.0	-2.2	-1.9	-2.8	-2.3
Neuroticism (Nagel 2018)	2.0	4.7	7.1	-1.5	-1.7	-2.1	-2.2	-2.7	-2.2	-2.6
Prostate Cancer	2.0	2.8	14.3	3.8	-2.0	0.5	0.3	0.8	0.3	0.5
Qualifications: CSEs or equivalent	2.0	2.7	5.6	1.3	0.7	2.1	1.5	1.1	2.4	1.9
Glaucoma (self-reported)	2.0	2.3	8.4	2.9	0.7	0.5	-2.2	0.9	-1.1	0.1
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	4.7	1.0	1.4	1.1	2.2	1.0	2.1	1.7
Medication: Aspirin	2.0	2.6	6.6	1.3	1.0	2.6	0.9	1.9	1.2	1.6
Tinnitus: Yes, now most or all of the time	2.0	2.4	3.5	1.4	0.7	1.5	1.4	1.7	1.9	1.9
Pain experienced in last month	2.0	3.3	4.3	1.3	2.1	1.6	1.7	1.7	2.1	2.1
Neuroticism (2016)	1.9	2.8	5.9	0.3	-1.9	-0.7	-2.3	-0.9	-2.4	-1.8
Noisy workplace	1.9	2.3	4.4	-1.7	-1.2	-2.1	-1.1	-1.5	-1.2	-1.5
Illnesses of father: Heart disease	1.9	2.6	8.2	-0.7	-1.8	-0.9	-2.9	-0.4	-2.0	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	7.7	-0.7	1.9	2.5	2.8	1.4	2.2	1.9
Hair Pigment	1.8	51.8	161.3	12.7	8.8	7.2	3.5	6.2	1.2	4.3
Allergy	1.8	4.2	9.8	-2.6	-0.4	-2.1	-0.4	-3.1	-1.2	-2.5
Length of working week for main job	1.8	2.0	4.1	1.4	1.6	0.7	2.0	0.5	1.7	1.2
Neuroticism	1.7	4.1	6.1	-1.6	-2.1	-2.5	-1.6	-2.2	-1.8	-2.2
Hearing difficulty/problems: Yes	1.7	2.7	11.9	3.5	0.3	1.4	-0.3	1.7	0.5	1.2
Financial difficulties in last 2 years	1.7	2.3	6.0	-1.8	-1.4	-2.4	-0.8	-1.3	-0.9	-1.2
Age at first live birth	1.7	2.9	6.6	0.9	1.4	1.3	2.6	1.5	1.9	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	1.9	2.9	1.2	1.0	1.3	1.4	1.5	1.7	1.6
Eye problems/disorders: Glaucoma	1.7	2.0	6.4	2.5	0.5	0.6	-2.3	0.8	-1.1	0.1
Medication: Lisinopril	1.7	2.2	5.0	0.5	1.7	0.7	1.4	1.4	2.2	1.8
Unable to work because of sickness or disability	1.7	2.2	3.6	-0.8	-0.6	-1.8	-1.6	-1.9	-1.5	-1.8
Fasting Glucose	1.6	1.9	4.5	2.1	0.1	1.8	-1.0	1.9	-0.2	1.0
Hair/balding pattern: Pattern 2	1.6	2.0	4.5	2.1	1.8	1.7	-1.2	1.3	-0.5	0.6
Pulse wave Arterial Stiffness index	1.6	1.9	5.5	-0.9	0.8	0.0	2.0	0.4	2.3	1.4
Handedness (chirality/laterality): Left-handed	1.6	1.9	3.5	1.7	1.4	1.5	0.5	1.9	0.7	1.5
Average weekly beer plus cider intake	1.6	2.2	3.4	1.8	1.3	1.6	0.9	1.5	1.5	1.6
Ever depressed for a whole week	1.6	2.0	5.0	-0.1	-2.2	-1.7	-1.4	-0.6	-1.5	-1.1
Maternal smoking around birth	1.5	2.2	4.9	2.2	1.6	1.0	1.1	1.5	1.1	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	4.4	-1.0	-0.1	-2.1	-1.0	-1.8	-1.3	-1.7
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	6.1	2.5	-1.8	0.1	-1.5	1.4	-0.5	0.7
Prospective memory result	1.5	1.8	3.0	-0.9	-1.7	-1.5	-0.9	-1.5	-1.0	-1.5
Impedance of whole body	1.5	7.7	23.8	-3.1	-4.9	-3.5	0.0	-2.5	0.7	-1.2
Major Depression (MDD)	1.4	1.7	4.0	-0.5	-2.0	-1.1	-1.1	-0.8	-1.6	-1.3
Pack years adult smoking proportion	1.4	2.1	4.0	-0.8	-1.6	-2.0	-0.8	-1.7	-1.1	-1.6
Average weekly fortified wine intake	1.4	1.7	3.1	0.6	-0.8	-1.8	-0.9	-1.4	-1.7	-1.5
Neuroticism score	1.4	2.9	5.1	-1.7	-1.8	-2.2	-0.3	-2.2	-1.0	-1.9
Number of full brothers	1.4	1.8	3.1	-1.4	-0.8	-1.8	-0.6	-1.4	-1.5	-1.6
Illnesses of siblings: Diabetes	1.4	1.7	5.0	0.3	-1.1	1.4	2.2	0.9	1.4	1.1
Alcohol drinker status: Never	1.4	1.7	5.0	-2.2	-1.0	-1.2	-0.6	-1.1	-1.0	-1.3
Depressed Affect (Nagel 2018)	1.3	2.7	5.3	-1.4	-0.9	-1.9	-1.0	-2.3	-1.4	-2.1
Worry (Nagel 2018)	1.3	2.6	3.5	-0.9	-1.9	-1.7	-1.8	-1.7	-1.5	-1.7
Triglycerides	1.3	2.2	5.6	2.4	1.6	0.8	0.3	1.1	1.6	1.6
Allergy or Eczema	1.3	3.4	8.6	2.9	-0.8	1.4	0.7	2.5	1.1	2.2
Tense / ‘highly strung’	1.3	2.2	6.2	-0.9	-2.5	-1.0	-1.1	-1.7	-1.0	-1.4
Eye problems/disorders: None of the above	1.3	1.5	3.7	-1.9	-1.6	-0.8	0.1	-1.5	-0.5	-1.1
Knee pain experienced in last month	1.3	2.1	3.0	-1.7	-0.7	-1.7	-1.3	-1.1	-1.7	-1.6
Hypertension (Self-reported)	1.3	3.5	8.4	0.8	1.1	1.0	2.3	1.7	2.9	2.3
Commuting to job workplace: Walk	1.3	1.4	2.8	1.0	1.1	1.4	0.1	1.7	1.1	1.5
Bipolar Disorder (2011)	1.2	1.2	6.4	0.3	-2.5	-1.3	0.0	0.0	0.0	0.0
High blood pressure	1.2	3.3	8.3	0.7	1.3	0.9	2.2	1.5	2.9	2.2
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	3.9	0.3	-1.2	-1.6	-2.0	-0.5	-1.3	-0.9
Pulse wave reflection index	1.2	1.4	3.3	-0.5	1.0	1.1	1.4	0.7	1.8	1.3
Pulse wave peak to peak time	1.2	1.4	3.6	1.3	-0.6	0.7	-1.7	0.2	-1.9	-0.8
Depression (Nagel 2018)	1.1	1.6	2.7	-0.6	-0.1	-1.4	-1.2	-1.6	-1.6	-1.6
Supplements: Glucosamine	1.1	1.5	3.8	-2.0	0.3	-1.5	1.8	-0.7	0.1	-0.4
Medication: Cholesterol lowering	1.1	1.7	4.4	-0.8	-0.7	-1.6	-2.1	-1.2	-0.9	-1.2
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.5	1.9	0.2	1.2	-1.1	1.2	0.7	1.1
Comparative body size at age 10	1.1	3.0	8.8	0.7	1.7	0.1	-2.7	-0.1	-3.0	-1.4
Supplements: Vitamin C	1.1	1.3	3.4	1.8	-1.0	0.8	0.5	1.3	0.7	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	2.7	-0.5	-0.9	-1.2	-0.6	-1.0	-1.6	-1.4
Ever taken oral contraceptive pill	1.1	1.2	3.4	-1.9	0.1	-1.8	-0.1	-1.1	0.5	-0.4
Type 2 Diabetes (T2D) (2012)	1.0	1.2	3.4	-0.0	-1.8	-0.9	-1.1	-1.0	-0.8	-0.9
Sensitivity / hurt feelings	1.0	1.7	3.9	-0.5	-0.6	-0.4	-1.8	-1.2	-2.0	-1.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.5	-1.9	-1.3	-0.9	0.2	-0.3	-0.8	-0.8
Medication: Co-codamol	1.0	1.1	5.3	-0.8	0.8	-0.1	2.3	0.1	0.9	0.5
Nervous feelings	1.0	1.9	2.6	-1.1	-1.6	-1.5	-1.4	-1.2	-1.4	-1.4
Father’s age at death	1.0	1.3	2.2	0.3	0.9	1.3	0.8	1.3	1.4	1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	3.1	1.2	0.6	1.8	-1.1	1.1	-0.5	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	3.3	-0.0	1.8	0.7	1.0	0.7	1.1	1.0
Risk taking	1.0	1.4	3.1	0.6	0.9	1.7	-1.4	1.4	-1.2	0.2
Verbal and Numeric Reasoning (VNR)	0.9	2.1	5.8	0.7	1.8	2.4	0.6	1.7	0.5	1.2
HbA1C	0.9	1.0	2.5	1.6	0.2	0.1	0.8	1.1	0.9	1.3
Primary Biliary Cirrhosis	0.9	1.3	2.8	-0.3	-0.5	-1.7	-1.1	-1.2	-1.3	-1.3
Supplements: Zinc	0.9	1.0	1.7	0.9	0.7	1.0	1.3	1.3	0.5	1.0
Medication: Ibuprofen	0.9	1.1	3.8	-0.2	0.4	-1.9	0.2	-1.4	-0.7	-1.1
Heart disease (mother)	0.9	1.1	2.0	-1.1	-1.4	-0.8	-1.3	-0.6	-0.9	-0.9
Pulse rate, automated reading	0.9	2.9	13.2	1.6	3.6	0.6	0.3	1.6	0.5	1.2
Family relationship satisfaction	0.9	1.1	4.7	-0.2	-2.2	-0.9	-0.7	-0.6	-0.7	-0.7
Leg pain on walking	0.9	1.1	3.6	-1.9	0.5	-1.0	0.5	-1.3	-0.4	-1.0
Average weekly red wine intake	0.9	1.3	2.5	1.6	1.2	1.6	-0.4	1.2	0.3	1.0
Irritability	0.9	1.5	5.0	-2.2	-0.7	-0.9	1.0	-1.5	0.1	-0.9
BMI	0.8	4.8	23.8	0.9	4.9	2.0	0.4	1.7	0.3	1.2
Lung FVC	0.8	3.8	21.5	0.7	4.6	1.7	0.3	1.2	-0.4	0.5
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	5.5	2.3	-0.7	0.5	-0.0	0.7	-0.3	0.2
Medication: Atenolol	0.8	1.0	3.4	0.1	0.8	0.9	1.2	0.4	1.8	1.0
Hearing difficulty/problems with background noise	0.8	1.2	2.7	1.6	-0.2	1.4	0.2	1.6	0.5	1.2
Had menopause	0.8	1.0	5.0	-0.1	-2.2	0.2	-0.8	0.5	-0.9	-0.2
Illnesses of siblings	0.8	1.1	4.1	0.2	2.0	-0.3	-1.6	-0.4	-0.6	-0.4
Impedance of arm (right)	0.8	3.6	10.8	-2.5	-3.3	-2.1	0.3	-1.5	1.0	-0.4
Time employed in main current job	0.8	0.9	2.8	-0.1	-0.9	-0.7	-1.1	-1.7	-0.4	-1.1
Hair/balding pattern: Pattern 3	0.8	1.1	4.7	-0.4	-2.2	-0.9	-0.6	-0.7	-0.8	-0.8
Birth weight of first child	0.8	1.5	5.5	1.1	1.3	2.3	-0.9	1.1	-0.0	0.7
Medication: Amlodipine	0.8	1.1	2.8	-0.7	0.4	0.6	1.7	0.8	1.5	1.1
Mood swings	0.8	1.4	2.0	-1.1	-1.4	-1.2	-0.3	-1.4	-0.9	-1.4
Diabetes diagnosed by doctor	0.8	1.3	2.5	-0.3	-1.6	-0.8	-1.6	-1.0	-1.0	-1.1
Breast cancer (self-reported)	0.8	1.0	2.1	1.4	-0.4	1.2	-1.3	0.9	-0.8	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.8	-0.1	2.0	1.4	-1.4	0.5	-1.7	-0.6
Wears glasses or contact lenses	0.8	0.9	3.1	-0.8	-1.8	-1.1	-0.4	-0.8	-0.4	-0.6
Medication: Blood pressure	0.8	1.5	3.7	0.8	1.3	0.2	1.5	0.8	1.9	1.3
High cholesterol (Self-reported)	0.8	1.5	2.6	-1.1	-0.8	-1.6	-1.3	-1.3	-1.0	-1.2
Myopia	0.8	1.1	2.6	1.0	0.9	1.2	0.8	1.6	0.4	1.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.9	0.4	1.4	0.9	0.8	0.9	1.2	1.1
Schizophrenia vs Biploar Disorder	0.7	0.9	3.0	-0.4	1.2	0.2	1.7	0.4	0.9	0.7
Waist Hip Ratio (WHR)	0.7	3.2	8.7	-2.0	-2.0	-3.0	1.2	-1.7	0.3	-1.1
Type 2 Diabetes (T2D) (2018)	0.7	1.4	3.7	-0.6	-1.9	-1.1	-0.9	-1.0	-1.0	-1.2
Medication: Metformin	0.7	1.0	2.2	-0.5	-0.8	-0.0	-1.5	-0.7	-1.5	-1.2
Diabetes (father)	0.7	0.9	2.4	-0.2	1.6	0.8	0.8	0.7	1.0	0.9
Medication: Levothyroxine sodium	0.7	1.2	2.8	-1.3	-0.7	-1.7	0.4	-1.5	0.0	-0.9
Number of incorrect matches in round	0.7	1.1	4.5	-2.1	-0.0	-1.1	0.4	-1.1	0.0	-0.7
Impedance of arm (left)	0.7	3.5	14.1	-1.9	-3.8	-2.1	-0.0	-1.2	0.8	-0.4
Arm fat mass (right)	0.7	2.9	11.4	0.2	3.4	2.0	0.3	1.8	0.5	1.2
Blood clot in the leg (DVT)	0.7	0.8	1.5	0.2	1.2	0.8	0.9	0.9	1.1	1.0
Medication: Allopurinol	0.7	0.9	2.5	-0.3	1.0	0.1	1.4	0.1	1.6	0.8
Alcohol intake frequency.	0.7	1.6	3.9	-2.0	-1.2	-1.5	-0.0	-1.5	-0.5	-1.2
Overall health rating	0.7	1.4	2.3	-0.5	-1.5	-1.5	-1.1	-1.3	-0.7	-1.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.2	-1.5	-0.4	-0.1	1.3	-0.9	1.0	-0.0
Miserableness	0.7	1.1	2.5	-0.7	-1.0	-1.4	-0.1	-1.6	-0.7	-1.2
Guilty feelings	0.7	1.0	3.1	-0.5	-1.7	-0.8	-0.8	-1.1	-0.8	-1.0
Age started oral contraceptive pill	0.7	0.9	2.6	-0.8	-0.6	-0.5	-0.9	-0.5	-1.6	-1.1
Pack years of smoking	0.7	1.1	2.0	-0.5	-1.4	-1.4	-0.4	-1.3	-0.7	-1.1
Alzheimer’s Disease (in father)	0.6	0.7	1.5	0.7	-1.2	0.2	-0.9	-0.2	-1.2	-0.8
Crohns Disease (2017)	0.6	1.2	3.3	0.9	0.6	1.5	-0.2	1.8	0.4	1.3
Schizophrenia (2014)	0.6	1.3	3.5	0.1	-1.9	-1.5	0.0	-0.9	-1.2	-1.0
Respiratory disease	0.6	1.3	3.6	0.8	0.1	1.1	-0.2	1.9	0.8	1.6
Chronotype (morning person)	0.6	1.5	3.2	-1.8	1.8	-1.0	0.8	-1.4	0.1	-0.7
Tanning	0.6	6.9	16.5	-4.1	-3.8	-2.8	-1.2	-1.9	-1.1	-1.8
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.6	-1.1	-0.8	-1.0	-0.3	-1.3	-0.5	-0.9
Angina	0.6	0.7	1.8	-0.2	-1.3	-0.7	-0.7	-1.2	-0.3	-0.9
Current tobacco smoking	0.6	1.0	2.2	-0.5	-1.1	-1.5	0.8	-0.9	-0.9	-1.0
Had other major operations	0.6	0.7	3.8	0.6	-0.7	0.1	-1.9	-0.0	-0.5	-0.1
Pain all over the body in last month	0.6	0.7	2.6	-0.0	1.6	0.2	0.3	0.3	1.2	0.8
Number of live births	0.6	0.9	2.9	1.7	-0.4	0.8	-1.4	0.5	-0.1	0.3
Mouth/teeth dental problems: Dentures	0.6	1.0	1.8	0.2	-0.8	-1.3	-0.3	-1.0	-1.3	-1.3
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.2	0.8	0.6	1.4	1.5	0.8	0.6	0.9
High blood pressure (siblings)	0.6	0.8	2.8	0.2	-1.7	0.0	1.4	0.1	0.9	0.4
Neck or shoulder pain in last month	0.6	0.9	1.7	1.1	-1.3	0.5	0.8	1.3	0.5	1.0
Mean time to correctly identify matches	0.6	1.2	3.2	-1.3	-1.8	-1.5	-0.6	-0.5	-0.5	-0.7
Qualifications: nursing, teaching	0.6	1.0	2.3	-0.3	1.5	1.1	0.5	0.9	0.9	1.1
Medication: Gliclazide	0.6	0.7	1.6	0.6	0.3	-0.2	-1.3	-0.7	-1.1	-0.9
Arm fat mass (left)	0.6	2.6	10.2	0.1	3.2	1.8	0.3	1.7	0.5	1.1
Hearing aid user	0.6	0.7	1.7	1.3	1.2	0.1	0.6	0.8	0.5	0.6
Mother’s age at death	0.6	0.7	1.4	-1.2	0.4	-1.1	-0.2	-0.8	-1.0	-0.9
Medication: Paracetamol	0.6	1.0	1.8	-0.0	-0.3	-1.3	-1.0	-1.1	-1.2	-1.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.4	0.2	-0.3	-0.0	1.6	0.1	1.3	0.8
Fractured/broken bones in last 5 years	0.6	0.7	2.8	-1.7	-1.0	-0.5	0.8	-0.5	0.2	-0.3
Diastolic blood pressure, automated reading	0.6	1.9	6.9	-0.1	2.6	0.2	0.6	0.9	1.8	1.4
Basal cell carcinoma (self-reported)	0.6	0.7	1.8	1.3	0.1	1.3	-0.3	1.0	-0.4	0.4
Schizophrenia (2018)	0.5	1.0	2.7	0.7	-1.6	-1.1	0.2	-0.9	-1.0	-0.8
Reaction Time	0.5	1.0	1.8	-1.3	-1.4	-1.1	-0.7	-0.6	-0.7	-0.8
Mean Putamen Volume	0.5	0.6	2.2	-0.6	-0.5	-0.8	0.1	-1.5	0.1	-0.8
Blood Eosinophil Count	0.5	3.7	7.7	2.8	2.4	2.0	-0.7	2.4	-0.2	1.5
Average weekly spirits intake	0.5	0.6	1.4	-1.2	-0.3	-0.2	-1.0	-0.5	-0.9	-0.8
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.1	1.5	1.1	0.5	-0.4	0.7	-0.1	0.5
Vitamin and mineral supplements	0.5	0.7	3.2	0.3	0.1	-0.1	-1.8	-0.1	-1.2	-0.7
Relative age voice broke	0.5	0.8	2.0	1.0	-0.3	1.4	0.4	1.1	0.4	1.0
Taking other prescription medications	0.5	0.8	1.7	0.2	-0.9	-1.3	-0.6	-1.2	-0.5	-1.0
Multivitamins +/- minerals	0.5	0.7	2.0	0.1	1.2	0.7	1.4	0.3	0.6	0.5
Stomach or abdominal pain in last month	0.5	0.6	1.6	1.3	-0.5	0.9	-1.1	0.5	0.1	0.4
Trunk fat mass	0.5	2.2	6.9	-1.0	2.6	1.4	0.9	1.4	1.0	1.2
Alcohol usually taken with meals	0.5	0.8	1.9	-1.0	0.2	0.2	-0.9	-0.7	-1.4	-0.9
Diabetes (self-reported)	0.5	0.8	2.1	0.1	-1.4	-0.3	-1.2	-0.7	-0.9	-0.8
Hip circumference	0.5	2.3	7.6	-0.9	2.8	1.8	0.8	1.3	1.0	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.8	0.2	-0.4	-1.7	0.3	-0.9	-0.5	-0.7
Exposure to tobacco smoke at home	0.5	0.6	2.0	-0.6	0.0	0.3	1.0	0.1	1.4	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.3	-0.2	-0.2	-1.0	-0.8	-0.6	-1.5	-1.1
Loud music exposure frequency	0.5	0.5	0.9	-0.0	-0.7	-0.9	-0.5	-0.8	-0.9	-0.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	2.3	0.5	0.2	0.2	0.1	0.8	1.5	1.3
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	3.4	-0.3	0.3	-0.2	1.5	-0.2	1.9	0.8
Birth weight	0.5	1.0	3.7	0.9	-0.5	1.9	-0.7	0.9	-1.0	0.1
Chest pain or discomfort	0.5	0.8	2.6	-0.7	-1.6	-1.0	-0.0	-0.8	-0.3	-0.7
Loneliness, isolation	0.5	0.6	2.0	-1.2	-0.1	-0.1	1.4	-0.1	1.0	0.3
Ever had bowel cancer screening	0.5	0.6	3.0	-0.2	-1.7	-1.0	0.2	-0.4	-0.1	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	3.6	1.9	0.1	1.0	0.5	0.8	0.0	0.4
Illnesses of father: None of the above (group 1)	0.5	0.6	1.4	0.8	1.1	0.1	1.2	-0.3	0.9	0.4
Number of self-reported non-cancer illnesses	0.5	0.9	1.8	0.9	0.3	-0.5	1.3	0.9	1.1	1.0
Alzheimer’s Disease (in mother)	0.4	0.4	1.5	-0.1	0.2	1.2	0.1	0.6	0.9	0.7
Breast Cancer	0.4	1.0	2.9	0.2	-0.8	-0.4	-1.5	-0.2	-1.7	-0.9
HDL Cholesterol	0.4	0.6	3.4	-0.7	-1.8	0.4	-0.2	0.1	0.3	0.3
Rheumatoid Arthritis	0.4	0.6	1.1	-1.0	0.5	0.8	-0.9	-0.3	-0.9	-0.6
Smoking Status	0.4	0.9	2.8	-0.6	-1.7	-1.3	0.5	-0.5	-0.8	-0.7
Relative age of first facial hair	0.4	0.9	2.0	1.4	-1.2	0.6	-1.1	0.4	-0.9	-0.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	-0.9	-0.4	-0.7	-0.0	-0.9	-0.6	-0.9
Age when periods started (menarche)	0.4	0.9	1.9	-1.1	-0.5	-1.0	1.3	-0.3	1.4	0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	2.3	1.5	0.7	-0.0	0.3	0.4	0.1	0.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.5	0.9	-1.2	0.1	-0.3	0.7	-0.2	0.4
Body mass index (BMI)	0.4	1.9	10.3	0.6	3.2	0.9	-0.9	0.8	-0.8	0.0
Past tobacco smoking	0.4	0.7	1.8	-1.0	0.6	-0.9	-0.0	-1.4	-0.1	-0.9
Mouth/teeth dental problems	0.4	0.6	3.2	-1.8	1.0	-0.1	-0.2	-0.2	0.1	-0.0
Illnesses of mother	0.4	0.5	1.4	1.2	0.7	-1.0	0.1	-0.5	-0.7	-0.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.3	1.5	-0.8	0.0	-0.4	0.3	0.2	0.3
Leg fat percentage (right)	0.4	1.6	3.5	-1.9	0.3	-1.8	-0.8	-1.5	-0.3	-1.2
Exposure to tobacco smoke outside home	0.4	0.5	1.0	0.7	-0.5	-0.1	0.6	1.0	0.8	0.9
Medication: Omeprazole	0.4	0.5	0.9	-0.0	-0.9	-0.7	-0.7	-0.5	-0.8	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.7	0.1	-0.0	-0.2	-1.6	0.0	-0.9	-0.4
Whole body fat mass	0.4	1.7	6.4	-0.8	2.5	1.3	0.5	1.2	0.7	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	1.0	-0.4	0.6	-0.3	0.8	0.7	0.8
Illnesses of father: High blood pressure	0.4	0.4	1.3	-0.1	-0.0	0.7	0.6	0.6	1.1	0.8
Commuting to job workplace: Cycle	0.4	0.5	1.4	0.6	0.9	0.8	0.2	1.2	-0.2	0.6
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.2	0.2	-0.6	0.2	-1.7	-0.3	-1.8	-0.9
Cholesterol lowering medication	0.4	0.5	1.3	-0.9	-0.3	-1.1	-0.2	-0.7	-0.6	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.8	-0.0	-0.9	-0.6	-0.9	-0.5	-0.9	-0.7
Alcohol drinker status: Previous	0.4	0.5	1.3	1.1	0.2	-1.1	-0.5	-0.5	-0.6	-0.4
Alzheimer’s Disease (including proxy)	0.3	0.4	1.8	0.4	-0.3	1.4	-0.1	0.7	0.3	0.5
Coronary Artery Disease (CAD)	0.3	0.3	0.7	-0.7	-0.3	-0.8	-0.1	-0.6	-0.4	-0.6
Blood Red Count	0.3	2.6	7.1	2.7	-0.3	2.1	-0.8	2.1	0.1	1.2
Blood White Count	0.3	2.1	7.0	2.6	0.4	-0.3	-2.3	0.2	-1.3	-0.5
Hypothyroidism (self reported)	0.3	0.8	3.2	-0.7	0.2	0.1	0.9	0.0	1.8	1.0
Ever had hysterectomy (womb removed)	0.3	0.3	0.5	0.6	0.3	0.2	0.7	0.7	0.5	0.6
Systolic blood pressure, automated reading	0.3	0.8	2.3	0.0	-0.8	-0.2	0.9	0.6	1.5	1.1
Qualifications: None of the above	0.3	0.7	2.4	0.0	-1.5	-1.2	0.3	-0.7	-0.3	-0.7
Fluid intelligence score	0.3	0.5	1.3	0.6	0.9	1.1	0.6	0.8	-0.1	0.4
Pulse rate	0.3	0.6	2.4	1.6	0.7	0.3	-0.5	0.7	-0.1	0.4
Happiness	0.3	0.3	1.7	-0.0	1.3	-0.5	0.2	-0.1	0.4	0.2
Asthma	0.3	0.6	1.8	0.6	0.0	0.0	-0.7	1.3	0.4	1.1
Depression (self-reported)	0.3	0.4	0.8	0.6	0.3	-0.8	0.9	0.4	0.6	0.6
Medication: Lansoprazole	0.3	0.4	0.9	-0.2	-0.8	-0.3	-1.0	-0.1	-0.8	-0.4
Lung cancer (father)	0.3	0.4	2.1	1.5	0.4	0.3	0.4	-0.2	0.1	-0.0
Breastfed as a baby	0.3	0.4	1.3	0.1	-1.1	0.3	-0.7	0.3	-0.8	-0.1
Hair/balding pattern: Pattern 4	0.3	0.7	1.6	-1.3	0.9	-0.5	0.1	-0.6	-0.9	-0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.3	0.6	-0.3	0.5	0.1	1.2	0.4	1.0
Health satisfaction	0.3	0.3	0.8	-0.5	0.5	-0.7	0.3	-0.6	0.9	0.2
Migraine (self-reported)	0.3	0.3	0.9	-0.4	0.7	-0.2	0.9	-0.4	0.7	0.1
Leg fat mass (right)	0.3	1.1	5.0	-0.9	2.2	0.9	0.2	0.7	0.3	0.4
Suffer from ‘nerves’	0.3	0.5	1.8	-0.2	-0.7	-0.5	-1.3	-0.5	-0.5	-0.4
Smoking status: Previous	0.3	0.5	1.5	0.6	-0.3	1.0	-0.3	1.2	0.1	0.8
Long-standing illness, disability or infirmity	0.3	0.5	1.2	-0.3	-0.9	-1.1	0.0	-0.9	-0.2	-0.7
Asthma (self-reported)	0.3	0.6	1.7	0.4	0.2	0.2	-0.8	1.3	0.4	1.1
Osteoarthritis (self-reported)	0.3	0.4	1.4	-0.4	-0.5	-0.9	-0.0	0.1	-1.2	-0.7
Smoking status: Current	0.3	0.5	1.4	-0.3	-0.9	-0.9	1.2	-0.2	-0.1	-0.2
Financial situation satisfaction	0.3	0.4	1.0	-0.7	0.9	-0.4	0.2	-0.2	1.0	0.4
Commuting to job workplace: Public transport	0.3	0.3	0.8	0.9	-0.5	-0.2	-0.6	0.5	-0.7	0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.1	0.1	-0.6	0.4	0.1	1.0	0.7	1.0
Medication: Bendroflumethiazide	0.3	0.4	0.9	0.0	0.9	0.2	0.7	0.4	0.9	0.7
Leg fat percentage (left)	0.3	1.3	3.2	-1.8	0.4	-1.6	-0.4	-1.3	-0.1	-1.0
Heart disease (siblings)	0.3	0.4	0.9	-0.4	-0.5	-0.1	-0.2	-0.6	-0.9	-0.9
Leg fat mass (left)	0.3	1.1	5.3	-0.9	2.3	0.9	0.5	0.7	0.4	0.5
Irritable Bowel Disease (IBD)	0.2	0.5	0.8	-0.1	0.8	0.8	-0.0	0.9	0.5	0.9
Ulcerative Colitis (UC)	0.2	0.3	0.6	-0.7	0.8	0.1	0.4	0.2	0.6	0.5
Age at First Birth	0.2	0.2	0.6	-0.5	-0.3	0.4	-0.5	-0.1	-0.8	-0.5
LDL Cholesterol	0.2	0.3	1.1	0.8	-1.1	0.2	-0.2	0.2	0.4	0.3
Lupus	0.2	0.4	1.2	-0.8	1.1	0.7	0.4	-0.2	0.0	-0.2
Ulcerative Colitis	0.2	0.2	1.1	-1.1	0.2	0.1	0.6	0.1	0.3	0.2
Systolic Blood Pressure	0.2	0.8	2.4	0.4	-0.7	-1.4	0.4	-0.3	1.5	0.6
Cardiovascular Disease	0.2	0.5	1.5	-0.3	0.5	-0.3	0.7	0.7	1.2	0.8
Lung FEV1/FVC ratio	0.2	1.2	6.7	-0.3	2.6	-0.0	0.8	0.8	0.1	0.4
Diabetes (mother)	0.2	0.3	0.8	-0.8	-0.9	-0.0	0.1	-0.3	0.4	0.0
Townsend deprivation index at recruitment	0.2	0.2	0.4	0.6	-0.6	-0.6	0.5	0.3	0.3	0.2
High blood pressure (mother)	0.2	0.3	0.7	-0.7	0.2	0.8	0.2	0.0	0.8	0.4
Waist circumference	0.2	0.6	2.1	-1.3	1.4	0.2	0.6	0.3	0.1	0.1
Heart attack	0.2	0.2	0.9	0.5	-0.2	0.9	-0.0	0.4	0.5	0.4
Medication: Ramipril	0.2	0.3	0.4	0.6	0.5	0.6	0.3	0.6	0.5	0.5
Arm fat percentage (right)	0.2	0.7	3.3	-0.7	1.8	-0.2	-0.9	-0.2	-0.3	-0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.5	2.4	0.5	1.6	0.3	-0.3	0.6	-0.4	0.2
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.6	0.6	-0.7	-0.4	-0.3	-0.1	-0.8	-0.5
Body fat percentage	0.2	1.0	3.2	-1.8	0.6	-1.1	-0.8	-0.8	-0.3	-0.8
Wheeze or whistling in the chest in last year	0.2	0.3	1.0	0.5	-1.0	0.3	0.2	0.7	0.3	0.5
Qualifications: College or University degree	0.2	0.7	2.5	0.1	1.6	1.1	-0.5	0.7	-0.6	0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.7	-0.3	0.8	0.7	0.5	0.2	0.3	0.2
Medication for pain relief, constipation, heartburn	0.2	0.4	1.7	-1.3	-0.3	-0.2	-0.3	-0.7	-0.1	-0.4
Angina (self-reported)	0.2	0.3	1.0	-0.1	-1.0	-0.4	-0.3	-0.8	0.2	-0.4
Number of full sisters	0.2	0.2	0.8	-0.7	-0.9	-0.4	0.0	-0.3	-0.0	-0.3
Arm fat percentage (left)	0.2	0.6	2.2	-0.7	1.5	-0.3	-1.0	-0.2	-0.5	-0.5
Friendships satisfaction	0.2	0.3	1.0	0.2	0.1	-0.3	1.0	0.7	0.5	0.5
Medication for cholesterol	0.2	0.4	1.0	-0.2	-1.0	0.2	-0.4	-0.3	-1.0	-0.6
Back pain experienced in last month	0.2	0.4	1.3	0.1	-0.4	0.4	-1.1	0.0	-0.9	-0.3
Mineral and other dietary supplements	0.2	0.3	0.6	0.4	0.2	0.0	-0.3	-0.8	-0.6	-0.8
Average weekly champagne plus white wine intake	0.2	0.2	0.7	-0.0	-0.1	0.2	0.9	0.7	0.0	0.5
Ever smoked	0.2	0.4	1.0	0.4	-1.0	0.0	-0.4	0.2	-1.0	-0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.8	0.6	0.1	0.9	0.1	0.3	0.6	0.4
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.5	-0.3	1.2	1.0	0.2	0.5	0.1	0.3
Ovarian Cancer	0.1	0.2	0.5	0.4	-0.1	-0.4	-0.7	-0.3	-0.5	-0.4
Number of treatments/medications taken	0.1	0.2	0.6	0.8	-0.7	-0.4	0.4	0.2	0.5	0.3
Medication for hormone replacement therapy	0.1	0.1	0.4	-0.3	-0.2	-0.4	-0.4	-0.6	-0.4	-0.3
Trunk fat percentage	0.1	0.6	2.6	-1.6	1.1	-0.4	-0.1	-0.0	0.3	-0.0
Fed-up feelings	0.1	0.1	0.4	0.1	0.4	-0.0	0.4	-0.6	0.3	-0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.1	-0.3	-0.4	0.3	-0.1	0.4	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.4	0.0	-0.5	-0.0	0.3	-0.6	0.3	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	0.2	0.6	0.3	0.1	0.1	0.3	0.2
Medication: Paracetamol	0.1	0.2	0.6	0.5	-0.3	-0.8	-0.6	-0.3	-0.4	-0.3
Emphysema/chronic bronchitis	0.1	0.1	0.5	-0.5	-0.7	-0.3	0.2	0.4	-0.1	0.2
Medication: Blood pressure	0.1	0.3	0.9	-0.5	-0.2	-0.6	-0.9	-0.3	0.1	-0.3
Medication: Seretide 50 evohaler	0.1	0.2	0.7	-0.1	-0.8	0.4	0.1	0.4	-0.2	0.1
Age at last live birth	0.1	0.1	0.3	-0.0	0.2	0.5	0.3	0.4	0.4	0.5
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.6	0.1	-0.8	-0.6	0.2	-0.2	0.1	-0.1
Supplements: Calcium	0.1	0.1	0.2	-0.3	-0.4	-0.3	0.2	-0.3	0.0	0.0
Blood Platelet Count	0.0	0.4	2.4	1.6	0.0	-0.5	-0.3	0.2	0.1	0.2
Medication: Atorvastatin	0.0	0.0	0.3	0.5	-0.1	0.0	-0.1	-0.0	-0.1	-0.1

Hub : Genes

MTL5

Models

Trait associations