[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (right) :

chr4:69,713-2,058,475

Best TWAS P=2.8e-36 · Best GWAS P=5.97e-33 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CRIPAK 0.31 0.15 enet 34 0.26 1.2e-31 -5.37 -7.1 1.6e-12 -0.07 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex FGFRL1 0.03 0.00 enet 7 0.01 1.7e-02 1.28 -9.3 1.9e-20 0.71 0.01 0.95 TRUE
3 CommonMind Brain Pre-frontal Cortex RNF212 0.14 0.11 lasso 6 0.11 2.3e-13 -5.47 5.6 1.7e-08 -0.03 1.00 0.00 FALSE
4 GTEx Adipose Subcutaneous CRIPAK 0.42 0.11 enet 42 0.34 9.0e-29 -5.36 -6.6 4.9e-11 -0.19 1.00 0.00 FALSE
5 GTEx Adipose Visceral Omentum UVSSA 0.46 0.05 lasso 11 0.24 1.1e-12 -6.15 -6.4 1.9e-10 -0.16 0.88 0.01 FALSE
6 GTEx Adipose Visceral Omentum CRIPAK 0.47 0.24 lasso 12 0.31 1.3e-16 -7.56 -7.9 2.2e-15 -0.10 1.00 0.00 FALSE
7 GTEx Artery Aorta UVSSA 0.33 0.06 enet 30 0.28 7.2e-16 -6.15 -5.8 7.6e-09 -0.17 0.94 0.00 FALSE
8 GTEx Artery Aorta CRIPAK 0.31 0.20 enet 34 0.30 2.8e-17 -7.56 -6.8 8.8e-12 -0.13 1.00 0.00 FALSE
9 GTEx Artery Coronary CRIPAK 0.35 -0.01 enet 35 0.10 2.8e-04 -5.29 -5.5 3.8e-08 -0.12 0.11 0.18 FALSE
10 GTEx Artery Tibial FGFRL1 0.08 0.00 enet 29 0.05 6.5e-05 0.64 9.2 6.0e-20 -0.23 0.17 0.28 FALSE
11 GTEx Artery Tibial CRIPAK 0.42 0.09 enet 50 0.34 1.3e-27 0.28 -5.2 1.8e-07 -0.15 1.00 0.00 FALSE
12 GTEx Artery Tibial MYL5 0.15 0.10 lasso 5 0.08 9.0e-07 -6.11 -6.1 1.1e-09 0.33 1.00 0.00 TRUE
13 GTEx Brain Caudate basal ganglia CRIPAK 0.27 0.00 lasso 2 0.02 9.3e-02 -6.15 -7.5 5.0e-14 -0.03 0.06 0.07 FALSE
14 GTEx Brain Cerebellum FGFRL1 0.32 0.01 enet 41 0.11 3.8e-04 3.51 7.2 4.2e-13 -0.55 0.06 0.48 FALSE
15 GTEx Brain Cerebellum CRIPAK 0.37 0.09 enet 24 0.31 8.8e-10 -5.36 -6.4 1.9e-10 -0.17 0.40 0.06 FALSE
16 GTEx Brain Cortex RNF212 0.15 0.03 lasso 3 0.01 1.5e-01 -5.46 6.0 2.6e-09 -0.10 0.10 0.11 FALSE
17 GTEx Brain Cortex CRIPAK 0.34 0.10 lasso 6 0.18 9.5e-06 -7.56 -8.1 5.0e-16 -0.11 0.20 0.05 FALSE
18 GTEx Brain Frontal Cortex BA9 CRIPAK 0.36 0.03 lasso 7 0.05 1.9e-02 -7.56 -6.2 4.9e-10 -0.08 0.06 0.05 FALSE
19 GTEx Brain Hippocampus CRIPAK 0.48 0.22 lasso 4 0.23 4.0e-06 -5.29 -7.1 1.4e-12 -0.18 0.20 0.05 FALSE
20 GTEx Brain Hypothalamus CRIPAK 0.22 0.00 lasso 5 0.01 2.1e-01 -6.15 -8.1 4.2e-16 -0.06 0.06 0.05 FALSE
21 GTEx Brain Nucleus accumbens basal ganglia CRIPAK 0.34 0.13 lasso 6 0.25 2.7e-07 -7.56 -8.3 1.1e-16 -0.02 0.21 0.04 TRUE
22 GTEx Brain Putamen basal ganglia CRIPAK 0.30 0.00 enet 25 0.10 1.9e-03 -4.71 -6.6 3.9e-11 -0.09 0.06 0.06 FALSE
23 GTEx Breast Mammary Tissue CRIPAK 0.42 0.12 enet 35 0.39 5.2e-21 -7.56 -6.6 3.7e-11 -0.10 1.00 0.00 FALSE
24 GTEx Breast Mammary Tissue (Male) CPLX1 0.24 0.01 lasso 2 0.06 1.7e-02 8.99 6.0 1.8e-09 0.03 0.04 0.05 FALSE
25 GTEx Breast Mammary Tissue (Male) CRIPAK 0.21 -0.01 enet 17 0.03 7.1e-02 -4.74 -5.3 9.1e-08 -0.13 0.09 0.09 FALSE
26 GTEx Breast Mammary Tissue (Female) UVSSA 0.21 0.02 enet 24 0.05 1.3e-02 -6.16 -5.4 7.2e-08 -0.11 0.08 0.05 FALSE
27 GTEx Breast Mammary Tissue (Female) CRIPAK 0.32 0.17 enet 29 0.26 2.7e-08 -5.51 -6.7 2.2e-11 -0.11 0.54 0.02 FALSE
28 GTEx Cells EBV-transformed lymphocytes CRIPAK 0.49 0.27 lasso 8 0.35 2.9e-12 -7.56 -8.3 1.3e-16 -0.05 0.84 0.01 FALSE
29 GTEx Cells Transformed fibroblasts CRIPAK 0.35 0.06 enet 33 0.22 3.0e-16 -5.29 -5.9 4.4e-09 -0.17 1.00 0.00 TRUE
30 GTEx Colon Sigmoid CRIPAK 0.40 0.21 lasso 7 0.30 4.7e-11 -6.16 -6.9 4.6e-12 0.00 0.72 0.01 FALSE
31 GTEx Colon Transverse CRIPAK 0.33 0.10 enet 22 0.24 5.8e-12 -5.29 -6.0 1.9e-09 -0.15 0.97 0.00 FALSE
32 GTEx Colon Transverse RP11-20I20.4 0.17 0.05 lasso 3 0.05 2.3e-03 -6.16 -6.5 7.3e-11 0.08 0.42 0.04 FALSE
33 GTEx Esophagus Gastroesophageal Junction UVSSA 0.30 0.00 enet 23 0.08 1.1e-03 -7.56 -7.8 4.7e-15 -0.05 0.29 0.04 FALSE
34 GTEx Esophagus Gastroesophageal Junction CRIPAK 0.33 0.20 lasso 5 0.30 1.4e-11 -7.56 -7.8 7.9e-15 -0.11 0.99 0.00 TRUE
35 GTEx Esophagus Mucosa CRIPAK 0.49 0.14 enet 28 0.40 6.8e-29 -7.56 -6.1 1.1e-09 -0.21 1.00 0.00 FALSE
36 GTEx Esophagus Muscularis UVSSA 0.35 0.03 enet 33 0.16 3.5e-10 -7.56 -6.4 1.7e-10 -0.07 0.94 0.00 FALSE
37 GTEx Esophagus Muscularis RNF212 0.13 0.00 lasso 6 0.00 8.6e-01 3.39 6.2 7.1e-10 -0.12 0.17 0.08 FALSE
38 GTEx Esophagus Muscularis CRIPAK 0.38 0.14 enet 34 0.30 2.6e-18 -7.56 -6.8 1.2e-11 -0.09 1.00 0.00 FALSE
39 GTEx Heart Atrial Appendage CRIPAK 0.31 0.26 enet 23 0.33 2.1e-15 -7.56 -7.0 2.9e-12 -0.10 1.00 0.00 FALSE
40 GTEx Heart Left Ventricle CRIPAK 0.19 0.05 enet 24 0.21 3.4e-11 -7.56 -7.5 4.6e-14 -0.10 0.65 0.02 FALSE
41 GTEx Lung CRIPAK 0.61 0.22 enet 46 0.41 1.1e-33 -7.56 -8.0 1.5e-15 -0.08 1.00 0.00 FALSE
42 GTEx Lung RP11-20I20.4 0.07 0.00 lasso 3 0.01 6.0e-02 -6.16 -7.1 9.5e-13 0.01 0.14 0.03 TRUE
43 GTEx Muscle Skeletal CRIPAK 0.25 0.11 enet 32 0.18 7.6e-18 -7.56 -6.5 6.5e-11 -0.13 1.00 0.00 FALSE
44 GTEx Nerve Tibial TMEM175 0.08 0.05 lasso 5 0.03 3.0e-03 -6.11 5.9 3.3e-09 -0.38 0.35 0.03 TRUE
45 GTEx Nerve Tibial CRIPAK 0.50 0.11 enet 76 0.38 1.1e-28 -5.29 -6.3 2.7e-10 -0.17 1.00 0.00 FALSE
46 GTEx Nerve Tibial CTBP1-AS2 0.18 0.03 lasso 5 0.03 3.2e-03 -6.01 -5.9 4.0e-09 -0.07 0.61 0.02 FALSE
47 GTEx Ovary UVSSA 0.33 0.10 enet 12 0.32 1.5e-08 -6.15 -5.8 9.1e-09 -0.07 0.11 0.08 FALSE
48 GTEx Ovary CRIPAK 0.43 0.27 enet 19 0.32 9.0e-09 -7.56 -7.1 1.6e-12 -0.12 0.47 0.05 TRUE
49 GTEx Pancreas CRIPAK 0.34 0.13 lasso 6 0.27 1.0e-11 -5.29 -7.3 2.3e-13 -0.13 0.84 0.01 FALSE
50 GTEx Skin Not Sun Exposed Suprapubic CRIPAK 0.39 0.14 lasso 13 0.34 1.5e-19 -7.56 -5.4 5.5e-08 -0.18 0.99 0.00 FALSE
51 GTEx Skin Sun Exposed Lower leg CRIPAK 0.36 0.09 enet 40 0.35 8.7e-30 -5.36 -6.0 1.6e-09 -0.17 1.00 0.00 TRUE
52 GTEx Spleen CRIPAK 0.35 0.08 lasso 5 0.25 4.6e-07 -5.29 -6.5 1.0e-10 0.05 0.16 0.05 FALSE
53 GTEx Stomach CRIPAK 0.43 0.22 enet 46 0.35 1.4e-17 -7.56 -5.4 6.6e-08 -0.18 1.00 0.00 FALSE
54 GTEx Thyroid FGFRL1 0.39 0.05 enet 47 0.14 6.9e-11 8.99 12.6 2.8e-36 -0.33 0.95 0.03 TRUE
55 GTEx Thyroid CRIPAK 0.51 0.14 enet 44 0.34 6.1e-27 1.68 -5.7 1.0e-08 -0.09 1.00 0.00 FALSE
56 GTEx Uterus CRIPAK 0.52 0.34 lasso 3 0.33 1.7e-07 -6.15 -7.7 1.6e-14 -0.03 0.24 0.05 FALSE
57 GTEx Whole Blood CRIPAK 0.38 0.17 lasso 9 0.28 3.4e-26 -5.29 -7.8 4.7e-15 -0.12 1.00 0.00 FALSE
58 METSIM Adipose CRIPAK 0.28 0.16 bslmm 335 0.25 2.7e-37 -4.74 -7.5 5.3e-14 -0.08 1.00 0.00 FALSE
59 METSIM Adipose MAEA 0.10 0.03 bslmm 392 0.07 4.4e-10 -7.56 6.1 9.3e-10 0.03 0.99 0.00 FALSE
60 METSIM Adipose SPON2 0.06 0.06 lasso 8 0.05 2.2e-08 -5.47 -6.1 1.2e-09 0.04 1.00 0.00 FALSE
61 METSIM Adipose UVSSA 0.26 0.04 bslmm 366 0.12 9.0e-18 0.47 -7.2 6.6e-13 -0.06 1.00 0.00 FALSE
62 NTR Blood CRIPAK 0.13 0.09 enet 31 0.15 1.5e-46 -6.03 -7.0 3.4e-12 -0.11 1.00 0.00 FALSE
63 NTR Blood KIAA1530 0.19 0.04 blup 345 0.10 9.1e-32 -6.15 -5.8 7.3e-09 0.00 1.00 0.00 FALSE
64 ROSMAP Brain Pre-frontal Cortex CRIPAK 0.31 0.23 lasso 12 0.40 6.4e-55 -4.74 -5.8 6.9e-09 -0.11 1.00 0.00 FALSE
65 YFS Blood CRIPAK 0.35 0.27 bslmm 301 0.33 6.0e-112 -5.29 -7.9 3.3e-15 -0.10 1.00 0.00 FALSE
66 The Cancer Genome Atlas Bladder Urothelial Carcinoma CRIPAK 0.11 0.07 lasso 4 0.05 2.0e-05 -5.29 -6.1 8.4e-10 -0.14 0.31 0.53 FALSE
67 The Cancer Genome Atlas Breast Invasive Carcinoma CRIPAK 0.22 0.11 blup 28 0.14 5.6e-28 -5.29 -8.1 8.0e-16 -0.06 1.00 0.00 FALSE
68 The Cancer Genome Atlas Breast Invasive Carcinoma KIAA1530 0.13 0.01 blup 48 0.03 4.9e-07 -5.36 -6.6 4.7e-11 -0.01 0.80 0.14 FALSE
69 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CRIPAK 0.17 0.06 blup 29 0.11 4.2e-06 -4.71 -6.6 5.0e-11 -0.10 0.01 0.98 FALSE
70 The Cancer Genome Atlas Colon Adenocarcinoma CRIPAK 0.38 0.16 blup 28 0.21 2.8e-12 -5.29 -7.4 1.2e-13 -0.12 0.16 0.84 FALSE
71 The Cancer Genome Atlas Glioblastoma Multiforme CRIPAK 0.35 0.15 lasso 5 0.14 4.3e-05 -4.71 -6.1 8.3e-10 -0.10 0.00 0.89 FALSE
72 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CRIPAK 0.28 0.16 blup 28 0.19 3.2e-21 -5.29 -7.7 2.1e-14 -0.10 0.98 0.02 FALSE
73 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma KIAA1530 0.25 0.05 enet 18 0.12 1.9e-13 -5.29 -5.4 5.9e-08 -0.10 0.91 0.06 FALSE
74 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CRIPAK 0.21 0.10 enet 9 0.15 1.3e-16 -5.29 -5.8 4.9e-09 -0.16 1.00 0.00 FALSE
75 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CRIPAK 0.12 0.08 lasso 2 0.07 4.5e-05 -5.06 -5.3 1.4e-07 -0.14 0.25 0.62 FALSE
76 The Cancer Genome Atlas Brain Lower Grade Glioma CRIPAK 0.31 0.11 enet 10 0.18 1.5e-19 -5.29 -6.4 1.3e-10 -0.14 0.99 0.01 FALSE
77 The Cancer Genome Atlas Brain Lower Grade Glioma KIAA1530 0.30 0.01 enet 12 0.08 1.4e-09 -7.56 -5.3 1.1e-07 -0.03 0.00 0.45 FALSE
78 The Cancer Genome Atlas Brain Lower Grade Glioma RNF212 0.05 0.05 lasso 1 0.04 1.3e-05 -5.47 5.5 4.5e-08 -0.07 0.72 0.02 FALSE
79 The Cancer Genome Atlas Liver Hepatocellular Carcinoma CRIPAK 0.13 0.06 blup 29 0.08 1.2e-04 -5.29 -6.0 1.4e-09 -0.15 0.07 0.33 FALSE
80 The Cancer Genome Atlas Lung Adenocarcinoma CRIPAK 0.09 0.07 lasso 1 0.06 1.5e-07 -5.29 -5.3 1.2e-07 -0.15 0.95 0.03 FALSE
81 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CRIPAK 0.14 0.05 lasso 4 0.07 6.1e-08 -5.29 -6.2 5.6e-10 -0.14 0.90 0.10 FALSE
82 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma CRIPAK 0.34 0.13 blup 29 0.19 3.9e-13 -7.56 -6.4 1.6e-10 -0.09 0.02 0.98 FALSE
83 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma DGKQ 0.11 0.01 blup 49 0.02 2.8e-02 0.90 -5.2 1.6e-07 0.18 0.04 0.04 FALSE
84 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma KIAA1530 0.40 0.10 blup 49 0.10 2.0e-07 -7.56 -6.3 2.2e-10 -0.09 0.01 0.98 FALSE
85 The Cancer Genome Atlas Pancreatic Adenocarcinoma CRIPAK 0.34 0.30 lasso 3 0.27 7.5e-12 -5.29 -5.4 7.5e-08 -0.15 1.00 0.00 FALSE
86 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma CRIPAK 0.41 0.10 lasso 4 0.08 5.2e-04 -5.29 -6.6 4.9e-11 -0.12 0.10 0.22 FALSE
87 The Cancer Genome Atlas Prostate Adenocarcinoma CRIPAK 0.27 0.17 enet 4 0.18 2.7e-18 -5.29 -6.0 1.7e-09 -0.15 1.00 0.00 FALSE
88 The Cancer Genome Atlas Prostate Adenocarcinoma IDUA 0.13 0.01 blup 51 0.10 6.0e-11 1.02 -7.6 3.1e-14 0.26 0.88 0.01 TRUE
89 The Cancer Genome Atlas Rectum Adenocarcinoma CRIPAK 0.37 0.07 lasso 2 0.12 1.2e-03 -5.29 -7.4 1.6e-13 -0.12 0.01 0.60 FALSE
90 The Cancer Genome Atlas Soft Tissue Sarcoma CRIPAK 0.20 0.10 lasso 5 0.15 2.2e-09 -7.56 -7.9 3.1e-15 -0.05 0.00 1.00 FALSE
91 The Cancer Genome Atlas Soft Tissue Sarcoma KIAA1530 0.08 0.03 enet 11 0.03 5.9e-03 -5.02 -6.4 2.0e-10 -0.11 0.03 0.48 FALSE
92 The Cancer Genome Atlas Skin Cutaneous Melanoma CRIPAK 0.57 0.07 enet 9 0.23 6.7e-07 -7.56 -7.0 2.2e-12 -0.06 0.01 0.88 FALSE
93 The Cancer Genome Atlas Stomach Adenocarcinoma CRIPAK 0.17 0.07 blup 29 0.08 1.3e-06 -7.91 -7.4 1.5e-13 -0.07 0.00 1.00 TRUE
94 The Cancer Genome Atlas Thyroid Carcinoma CRIPAK 0.38 0.22 enet 12 0.25 5.4e-24 -5.29 -7.1 1.5e-12 -0.10 1.00 0.00 FALSE
95 The Cancer Genome Atlas Thyroid Carcinoma FGFRL1 0.34 0.05 enet 32 0.17 1.2e-16 8.99 9.1 1.4e-19 -0.30 0.05 0.87 FALSE
96 The Cancer Genome Atlas Thyroid Carcinoma IDUA 0.19 0.04 enet 16 0.11 3.5e-11 -1.84 -6.2 4.6e-10 0.37 0.87 0.06 FALSE