Hub : Genes

TMEM175

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.4030	0.1110	3.5e-04	0.093	NA	0.158	NA	0.162	1.1e-03	NA	2.0e-05	NA	1.6e-05
2	GTEx	Nerve Tibial	0.0825	0.0364	6.4e-03	0.050	NA	0.019	NA	0.030	1.9e-04	NA	1.5e-02	NA	3.0e-03
3	GTEx	Thyroid	0.1260	0.0460	6.2e-04	0.037	NA	0.039	NA	0.055	7.6e-04	NA	5.8e-04	NA	4.9e-05
4	ROSMAP	Brain Pre-frontal Cortex	0.1417	0.0371	7.9e-10	0.033	0.084	0.070	0.081	0.049	4.3e-05	5.7e-11	2.6e-09	1.3e-10	6.6e-07
5	YFS	Blood	0.0501	0.0168	9.2e-06	0.022	0.017	0.018	0.020	0.016	5.4e-08	1.9e-06	8.4e-07	2.2e-07	4.6e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.6	2.6	-0.2	-0.0	0.1	-0.7	-1.6
Bipolar Disorder or Schizophrenia	0.4	0.9	2.3	0.8	0.1	0.7	-1.0	-1.5
Depressed Affect (Nagel 2018)	0.5	1.0	4.0	-0.5	0.3	-0.3	-0.7	2.0
Depression (Nagel 2018)	0.2	0.3	1.2	-0.1	0.1	0.3	-1.1	0.4
Intelligence (Savage-Jansen 2018)	0.5	1.4	3.1	-1.2	-1.0	-0.9	-0.9	-1.8
Neuroticism (Nagel 2018)	0.4	0.9	2.9	0.5	0.7	0.1	-0.9	1.7
Schizophrenia (2018)	0.3	0.6	1.5	1.2	0.1	0.8	-0.7	-0.7
Schizophrenia vs Biploar Disorder	0.4	0.5	2.0	-0.0	-0.1	-0.3	-1.4	-0.5
Worry (Nagel 2018)	0.3	0.7	1.9	0.6	0.6	-0.2	-1.4	0.9
Alzheimer’s Disease (in mother)	0.5	0.6	2.2	-0.0	-0.9	-0.3	0.3	-1.5
Alzheimer’s Disease (in father)	0.2	0.2	0.5	-0.7	-0.0	-0.4	0.5	0.1
Alzheimer’s Disease (including proxy)	0.5	0.8	1.9	0.1	-0.6	0.1	1.4	-1.2
Crohns Disease (2017)	0.2	0.5	1.1	0.5	0.7	0.8	0.3	-1.0
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	0.1	0.6	0.3	-0.7	0.3
Ulcerative Colitis (UC)	0.3	0.5	1.5	0.2	0.3	0.2	-0.8	1.2
Major Depression (MDD)	0.5	0.6	1.7	0.0	0.9	0.0	-0.7	-1.3
Reaction Time	0.7	1.3	3.7	0.8	1.4	1.9	0.2	0.3
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.0	0.9	0.1	0.5	-0.1	-1.4
Breast Cancer	1.5	3.5	6.2	-2.3	-1.2	-2.1	-2.5	-0.3
Ovarian Cancer	1.1	1.4	3.5	-1.9	-0.4	-0.6	-1.2	-1.2
Prostate Cancer	0.5	0.7	3.3	0.3	-0.2	0.5	1.8	-0.1
Age at First Birth	0.3	0.5	1.5	0.7	0.5	0.3	-0.3	1.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	1.8	-0.7	-1.0	-1.0	0.2	-1.4
Coronary Artery Disease (CAD)	4.8	5.7	8.2	-2.1	-2.9	-2.7	-2.3	-2.0
Crohns Disease (2012)	0.4	0.6	1.5	-0.0	-0.3	-0.2	-1.1	-1.2
Mean Putamen Volume	0.8	0.9	1.4	1.2	0.1	0.7	1.1	-1.2
Fasting Glucose	0.1	0.2	0.3	0.5	-0.1	0.6	0.3	0.2
HbA1C	0.6	0.7	1.3	-0.8	-1.0	-0.6	-1.1	0.0
HDL Cholesterol	0.8	1.3	1.9	0.5	1.1	1.1	1.3	1.4
LDL Cholesterol	0.7	1.1	2.3	1.1	1.2	0.1	1.5	-0.8
Lupus	0.5	0.7	2.0	0.6	0.3	0.8	1.4	0.6
Neuroticism (2016)	0.3	0.4	1.3	-0.3	-0.2	0.3	0.7	1.1
Primary Biliary Cirrhosis	1.4	1.9	4.3	1.9	1.1	2.1	0.4	-0.5
Rheumatoid Arthritis	0.3	0.5	1.1	0.1	-0.5	0.8	0.6	-1.0
Schizophrenia (2014)	0.4	0.8	1.8	1.1	0.2	0.7	-1.3	-0.8
Triglycerides	1.8	3.0	10.2	-0.9	-1.7	-0.9	-0.4	-3.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.8	0.0	-1.7	-0.7	-0.5	-0.3
Ulcerative Colitis	1.4	2.0	5.1	-1.2	-0.8	-1.6	-2.3	0.4
Blood Eosinophil Count	0.1	0.9	3.1	-0.1	-1.0	0.6	-0.0	-1.8
Blood Platelet Count	0.3	3.1	5.8	2.4	1.6	2.2	1.4	0.7
Blood Red Count	0.0	0.4	0.9	0.4	0.5	0.7	-0.5	1.0
Blood White Count	0.4	3.1	8.4	0.9	0.6	1.7	-1.8	-2.9
Heel T-Score	5.9	46.8	132.2	6.7	11.5	4.8	5.5	-1.9
BMI	0.3	1.7	3.6	-0.7	-1.2	-1.9	-0.8	1.6
Height	0.2	3.8	9.2	-3.0	-2.5	-1.3	-0.2	-1.3
Waist Hip Ratio (WHR)	5.0	22.3	42.2	-4.2	-4.4	-6.5	-2.7	-5.0
Systolic Blood Pressure	2.0	10.1	15.4	-2.9	-3.5	-3.9	-3.8	-0.5
Smoking Status	0.9	2.1	6.0	-1.3	-1.4	-1.0	2.4	0.2
Allergy or Eczema	0.5	1.4	5.0	-1.1	-0.3	-0.7	-2.2	-0.4
Cardiovascular Disease	1.8	6.0	11.0	-2.0	-1.7	-3.3	-3.3	-1.1
Hypothyroidism (self reported)	0.4	0.8	1.6	-0.5	-0.5	-1.1	-0.8	1.3
Respiratory disease	0.5	1.0	1.8	-1.0	-1.2	0.3	-1.0	-1.3
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.1	1.4	0.8	0.2	-1.2	-0.0
Lung FEV1/FVC ratio	0.6	3.2	9.9	-1.5	-0.5	-3.1	-1.9	0.1
Lung FVC	0.5	2.4	3.8	1.7	2.0	1.7	1.5	-0.1
Neuroticism	0.4	0.9	2.6	-0.4	-0.1	-0.9	-1.0	1.6
Chronotype (morning person)	1.0	2.2	5.2	0.9	2.2	0.1	-2.3	0.3
Hair Pigment	0.1	2.6	4.5	1.9	1.6	2.1	0.0	1.6
Tanning	0.1	1.4	4.5	0.5	0.8	2.1	1.2	0.5
Hand grip strength (left)	0.3	0.7	2.5	-1.6	-0.5	-0.7	-0.5	-0.1
Number of treatments/medications taken	1.4	2.6	4.9	-1.0	-2.0	-0.7	-2.2	-1.5
Average weekly spirits intake	1.5	1.9	3.7	1.1	1.9	1.7	1.2	0.2
Sensitivity / hurt feelings	0.6	1.0	2.5	0.2	-0.3	-0.7	-1.4	1.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.3	-0.5	0.2	-0.1	-1.1	0.0
Hearing difficulty/problems: Yes	0.9	1.3	2.6	0.7	0.3	1.5	1.0	1.6
Relative age of first facial hair	1.1	2.2	5.0	-2.1	-1.3	-2.2	0.1	0.1
Other serious medical condition/disability diagnosed by doctor	2.2	2.9	10.7	-0.0	-0.2	1.9	-0.4	-3.3
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.8	-0.9	-1.7	-1.2	0.1	-0.6
Ever had hysterectomy (womb removed)	0.6	0.6	1.6	0.8	-0.5	0.8	1.3	0.1
Systolic blood pressure, automated reading	4.5	13.0	20.5	-3.6	-4.3	-4.5	-3.5	-0.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	2.1	0.3	-0.2	0.0	0.0	1.4
Angina	0.4	0.6	1.4	-0.7	-0.0	-0.2	-1.2	-0.9
Medication for hormone replacement therapy	2.8	3.2	5.2	-1.2	-2.3	-2.1	-1.9	-1.1
Vitamin and mineral supplements	0.4	0.6	0.8	-0.3	-0.8	-0.9	0.9	0.8
Supplements: Zinc	0.6	0.6	1.9	-0.5	0.9	-0.3	0.5	-1.4
Medication: Co-codamol	1.3	1.4	3.2	-1.6	-1.8	-0.1	0.1	-1.2
Medication: Metformin	0.5	0.7	2.0	1.4	0.1	0.2	-0.1	1.1
Diabetes (father)	0.1	0.2	0.5	0.2	-0.1	0.4	0.4	0.7
Diabetes (mother)	1.8	2.3	5.5	-1.5	-2.3	-1.1	-1.4	-0.9
Severe depression (siblings)	0.6	0.7	2.3	-0.6	-1.5	-0.3	-0.6	-0.7
Pack years adult smoking proportion	0.9	1.3	3.1	0.3	0.5	0.5	1.8	1.7
Impedance of leg (right)	0.1	0.3	0.9	-0.7	0.4	0.0	0.0	-0.9
Leg fat-free mass (left)	0.2	1.0	3.7	-0.6	-0.7	-0.6	0.2	1.9
Trunk fat percentage	0.5	2.1	3.6	-1.2	-1.5	-1.9	-0.5	1.8
Hand grip strength (right)	0.4	1.2	2.1	-1.5	-0.4	-1.3	-0.3	1.3
Townsend deprivation index at recruitment	0.7	1.0	2.7	-0.3	-1.1	-1.6	-0.8	-0.5
Current tobacco smoking	0.6	0.9	3.0	0.1	0.9	0.7	1.7	0.5
Average weekly fortified wine intake	0.7	0.8	2.0	-1.4	-0.5	0.3	-0.3	-1.2
Maternal smoking around birth	0.7	0.9	1.6	0.9	0.2	1.2	1.3	0.9
Fed-up feelings	0.6	1.0	4.5	-0.3	-0.2	-0.5	-0.6	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.2	-0.3	0.4	0.5	0.3	1.1
Relative age voice broke	0.8	1.2	5.2	-0.3	-0.7	-0.4	2.3	-0.3
Taking other prescription medications	1.4	2.2	4.1	-1.2	-1.7	-0.4	-2.0	-1.6
Age when periods started (menarche)	0.5	1.1	4.8	-0.9	0.0	-0.2	0.2	-2.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.1	0.1	-0.7	0.8	0.9	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	6.2	14.1	40.1	3.9	6.3	2.9	2.5	0.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	0.0	1.1	0.9	-0.1	-0.1
Qualifications: CSEs or equivalent	0.8	1.1	3.0	-0.8	-0.1	-1.7	0.6	1.1
Serious illness, injury or assault to yourself	0.3	0.4	0.8	-0.6	-0.3	0.9	-0.7	-0.6
High blood pressure	2.1	5.9	13.5	-1.7	-2.4	-2.6	-3.7	-0.6
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.2	-1.2	-0.7	-1.1	-1.8	-0.4
Multivitamins +/- minerals	0.1	0.1	0.3	-0.2	0.3	0.2	-0.2	-0.6
Stomach or abdominal pain in last month	0.2	0.2	0.6	-0.7	0.5	0.3	-0.4	0.1
Supplements: Glucosamine	0.2	0.3	0.7	0.7	0.5	-0.4	-0.1	0.8
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	3.6	-0.7	-1.3	-0.4	-1.4	-1.9
Medication: Atenolol	0.6	0.7	1.7	1.2	-0.0	0.1	-0.6	1.3
Medication: Levothyroxine sodium	0.7	1.2	4.7	0.9	0.5	0.1	0.2	2.2
Sitting height	0.1	0.4	1.3	-0.1	-0.0	0.6	0.6	1.1
Chronic bronchitis/emphysema (father)	0.2	0.3	1.0	0.3	-0.4	-1.0	-0.1	-0.3
High blood pressure (mother)	0.5	0.7	1.5	-0.4	-1.1	-0.8	-0.4	1.2
Body mass index (BMI)	0.4	1.7	3.9	-0.4	-1.0	-1.7	-0.7	2.0
Impedance of leg (left)	0.1	0.4	1.1	-0.7	0.2	-0.4	-0.3	-1.0
Leg predicted mass (left)	0.2	1.2	3.3	-0.8	-1.0	-0.9	-0.0	1.8
Trunk fat mass	0.5	1.9	3.2	-1.2	-1.4	-1.8	-0.3	1.8
Waist circumference	2.3	8.2	16.1	-3.0	-3.2	-4.0	-2.4	0.1
Number of incorrect matches in round	1.7	2.9	6.4	1.9	2.5	2.0	0.6	0.3
Past tobacco smoking	0.7	1.3	2.5	1.6	1.2	1.0	-0.7	0.9
Alcohol usually taken with meals	0.2	0.3	1.2	0.0	0.4	-0.2	-1.1	-0.2
Nervous feelings	0.2	0.4	1.0	-0.1	-0.1	-0.6	-0.8	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.0	-0.9	-1.2	-1.4	-0.8	-0.1
Hearing difficulty/problems with background noise	3.3	5.2	8.6	1.5	2.2	2.8	1.7	2.9
Hair/balding pattern: Pattern 2	0.8	1.0	1.9	-0.5	-1.2	-1.4	-0.9	0.7
Had menopause	2.0	2.5	4.4	-1.9	-2.1	-1.9	-0.2	-0.7
Had other major operations	0.7	0.9	2.1	-1.4	-1.4	-0.4	-0.1	-0.4
Forced vital capacity (FVC)	0.2	0.6	1.7	0.7	1.3	0.8	0.1	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	5.2	11.9	34.9	3.5	5.9	2.7	2.2	0.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	0.9	-0.4	0.9	0.5	-0.9	-0.2
Qualifications: None of the above	0.4	0.8	1.8	1.2	0.4	1.3	0.6	0.2
Financial difficulties in last 2 years	0.4	0.6	1.9	-0.6	0.2	1.4	-0.2	0.6
Mouth/teeth dental problems	0.9	1.4	2.5	1.5	1.4	1.6	-0.5	-0.3
Heart attack	0.5	0.6	1.5	-0.2	-0.1	-1.2	0.3	1.2
Allergy	0.6	1.3	3.1	1.1	0.9	0.6	1.8	1.2
Pain all over the body in last month	1.5	1.6	3.5	1.0	0.5	1.9	1.8	0.1
Diabetes (self-reported)	0.2	0.3	0.6	0.8	-0.5	-0.3	-0.7	-0.5
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.5	-1.0	-0.8	0.1	-1.2	-1.0
Medication: Ramipril	0.6	0.8	1.3	-0.6	-1.0	-1.1	-0.5	-0.9
Medication: Simvastatin	0.8	1.2	4.0	-0.8	-0.5	-0.7	-2.0	-0.9
Fluid intelligence score	0.5	1.1	2.2	-0.2	-0.7	-1.2	-1.5	-1.2
Illnesses of siblings	0.2	0.3	0.6	-0.7	0.1	0.0	0.6	0.8
Neuroticism score	0.6	1.2	3.6	-0.4	0.4	-0.5	-1.4	1.9
Weight	0.4	2.1	4.2	-1.1	-1.3	-1.8	-0.4	2.1
Impedance of arm (right)	0.2	0.9	1.9	0.0	0.9	1.0	1.4	0.6
Arm fat percentage (right)	0.4	1.5	4.0	-0.5	-0.6	-1.6	0.1	2.0
Trunk fat-free mass	0.1	0.6	0.9	-0.9	-0.9	-1.0	-0.2	0.6
Hip circumference	0.6	2.4	6.9	-1.1	-1.3	-1.1	-1.0	2.6
Time employed in main current job	0.5	0.5	1.8	-0.6	0.5	0.5	0.1	1.4
Alcohol intake versus 10 years previously	1.6	2.4	5.5	-1.1	-1.7	-2.3	-1.5	-0.0
Father’s age at death	0.3	0.4	1.5	-1.2	-0.4	0.1	-0.6	-0.4
Worrier / anxious feelings	0.5	0.9	4.1	-0.0	0.4	0.0	-2.0	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	-0.4	-0.2	0.8	-0.5	0.3
Falls in the last year	0.2	0.3	0.6	-0.5	-0.4	0.8	-0.6	0.1
Hair/balding pattern: Pattern 3	1.1	1.6	2.9	-1.2	-0.8	-1.7	-1.3	-1.2
Number of live births	2.0	2.8	5.2	-1.6	-1.9	-2.3	-1.3	-0.8
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.5	0.2	0.7	-0.2	-0.5	0.1
Pulse rate	0.3	0.5	2.0	0.0	-0.4	1.4	-0.1	-0.6
Happiness	0.1	0.1	0.4	-0.5	0.6	0.1	0.2	0.0
Noisy workplace	0.3	0.4	0.9	-0.9	-0.7	0.4	-0.6	0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.9	0.7	0.5	0.2	-0.9	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.5	0.3	-0.2	-0.1	1.2	0.4
Mouth/teeth dental problems: Dentures	1.2	2.0	3.5	-1.8	-1.7	-1.9	0.5	-0.4
Asthma	1.5	3.0	6.2	-1.2	-2.1	-0.5	-1.7	-2.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.1	-1.4	-1.4	-0.3	-0.4	0.7
Medication: Cholesterol lowering	1.6	2.4	6.8	-1.0	-1.1	-1.4	-2.6	-1.1
Depression (self-reported)	0.1	0.2	0.4	-0.1	0.1	-0.7	-0.3	0.6
Medication: Lansoprazole	0.4	0.5	1.8	0.0	-0.5	-0.1	1.4	0.6
Prospective memory result	1.2	1.4	3.8	-1.2	-0.5	-1.1	-1.9	-0.5
Lung cancer (father)	0.3	0.3	0.7	0.1	-0.3	-0.7	-0.6	-0.8
Illnesses of mother	0.8	1.0	1.5	0.9	1.2	1.1	0.9	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.6	-0.3	0.2	-0.6	0.1	0.8
Pulse wave Arterial Stiffness index	1.0	1.1	3.8	0.0	-1.0	0.3	-1.0	-1.9
Impedance of arm (left)	0.1	0.4	0.9	-0.5	0.5	0.6	1.0	0.4
Arm fat mass (right)	0.4	1.6	3.7	-0.6	-1.0	-1.6	-0.1	1.9
Trunk predicted mass	0.1	0.6	0.8	-0.9	-0.9	-0.9	-0.1	0.6
Standing height	0.1	0.9	3.0	-1.7	-0.8	-0.3	0.7	0.3
Length of working week for main job	0.3	0.4	1.0	-1.0	0.3	-0.8	-0.0	0.1
Exposure to tobacco smoke at home	4.0	4.5	6.2	2.5	1.8	2.3	2.1	1.8
Breastfed as a baby	0.6	0.8	1.2	-1.1	0.1	-0.8	-0.9	-1.0
Tense / ‘highly strung’	0.5	0.8	1.4	-1.2	-0.8	-1.1	-1.0	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	4.7	-0.2	0.8	0.5	0.4	2.2
Hair/balding pattern: Pattern 4	1.8	4.3	5.3	2.3	2.3	2.2	1.9	1.5
Birth weight of first child	0.9	1.7	5.0	-1.5	-0.3	-2.2	0.2	1.1
Peak expiratory flow (PEF)	0.1	0.1	0.3	-0.1	0.6	0.1	0.2	0.6
Pulse wave reflection index	0.3	0.3	1.0	0.8	-0.2	0.0	1.0	0.0
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.1	0.0	1.0	1.4	0.1	0.9
Loud music exposure frequency	0.8	0.9	1.8	-1.4	-0.8	-1.1	-0.8	0.4
Qualifications: O levels/GCSEs or equivalent	1.0	1.7	4.1	-0.3	-0.0	-0.8	-1.8	-2.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.2	0.2	1.1	0.6	0.6	-0.3
Blood clot in the leg (DVT)	0.1	0.1	0.3	0.3	-0.2	0.0	-0.5	-0.5
Medication: Paracetamol	0.2	0.3	0.9	0.5	-0.2	0.6	0.9	0.3
Headache pain in last month	0.4	0.7	1.4	1.1	-0.1	0.8	1.2	-0.3
Medication for cholesterol, blood pressure or diabetes	3.0	5.0	11.8	1.6	1.8	2.0	3.4	1.9
Glaucoma (self-reported)	0.5	0.6	1.8	-0.2	-0.8	0.3	-0.4	-1.4
Gout (self-reported)	2.3	3.2	11.1	-0.9	-0.8	-0.7	-3.3	-1.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	2.2	0.3	-0.1	-0.4	0.4	1.5
Medication: Amlodipine	2.0	2.8	5.4	-2.3	-1.9	-2.1	-0.9	0.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.4	-1.1	-0.9	-0.7	-0.9	-1.2
Birth weight	0.1	0.2	0.6	-0.8	0.2	0.2	0.4	-0.6
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.2	0.2	0.1	-0.4	0.2	1.1
High blood pressure (siblings)	0.4	0.6	1.7	0.4	-0.5	-0.7	-1.3	0.6
Forced vital capacity (FVC), Best measure	0.0	0.1	0.2	-0.1	0.4	-0.1	0.2	0.2
Body fat percentage	0.5	2.1	4.0	-1.1	-1.2	-2.0	-0.5	1.9
Leg fat percentage (right)	0.5	1.6	3.6	-0.9	-0.8	-1.9	-0.6	1.7
Arm fat-free mass (right)	0.2	1.1	1.9	-1.0	-1.4	-1.4	-0.7	0.6
Exposure to tobacco smoke outside home	0.6	0.9	2.0	-0.7	-0.7	-0.5	-1.0	-1.4
Comparative body size at age 10	0.3	0.8	2.0	-0.8	0.2	-0.8	-1.4	0.6
Number of full brothers	2.4	3.0	9.6	-0.7	-1.0	-0.3	-2.0	-3.1
Worry too long after embarrassment	0.3	0.5	1.3	0.9	1.1	-0.0	-0.3	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.1	0.6	0.8	0.9	0.7	1.1
Wheeze or whistling in the chest in last year	0.1	0.2	0.6	-0.1	-0.1	0.8	-0.4	-0.7
Number of children fathered	2.6	2.9	5.8	1.8	1.0	2.4	2.1	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.3	1.1	0.5	0.5	0.2	1.5
Age at first live birth	0.4	0.8	2.5	0.1	1.2	0.0	-0.2	1.6
Pulse wave peak to peak time	1.2	1.4	4.2	0.2	1.1	0.0	1.2	2.0
Health satisfaction	1.3	1.7	4.8	-1.0	-0.3	0.8	-1.3	-2.2
Shortness of breath walking on level ground	1.5	1.8	3.7	-1.1	-0.7	0.0	-1.9	-1.9
Qualifications: College or University degree	0.3	0.9	3.5	0.3	1.9	0.5	0.2	0.9
Eye problems/disorders: None of the above	0.7	0.8	2.0	-0.8	-0.5	-1.4	-0.3	0.9
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.5	-1.2	-0.5	-0.7	-1.2	0.8
Emphysema/chronic bronchitis	0.4	0.5	0.8	0.4	0.9	0.7	0.7	-0.7
Medication for pain relief, constipation, heartburn	0.3	0.4	2.0	0.5	1.4	0.0	-0.2	0.2
Neck or shoulder pain in last month	0.6	0.8	3.0	0.4	0.0	1.7	-0.5	-0.8
Medication: Blood pressure	3.0	5.3	12.2	-1.8	-2.1	-1.8	-3.5	-1.8
Angina (self-reported)	0.3	0.4	1.0	-0.7	-0.0	-0.1	-1.0	-0.8
Migraine (self-reported)	1.0	1.2	2.4	-0.6	-0.9	-1.6	-1.5	0.1
Medication: Ibuprofen	0.3	0.3	0.6	-0.2	-0.4	0.7	0.6	0.8
Medication: Allopurinol	1.2	1.5	5.1	-0.2	0.4	0.8	-2.2	-1.3
Medication: Omeprazole	1.4	1.6	4.4	-0.8	-0.3	-0.2	-2.1	-1.7
Medication: Seretide 50 evohaler	1.7	1.9	3.4	-1.8	-1.6	0.1	-1.4	-1.2
Mean time to correctly identify matches	0.4	0.9	2.6	0.7	1.1	1.6	-0.1	-0.1
Heart disease (mother)	0.6	0.7	1.4	-0.7	0.0	-1.1	-1.2	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	-0.1	-0.4	0.2	-0.3	-0.7
Whole body fat mass	0.5	2.0	3.3	-1.1	-1.4	-1.8	-0.5	1.8
Leg fat mass (right)	0.5	1.9	3.5	-1.1	-1.2	-1.9	-0.8	1.6
Arm predicted mass (right)	0.2	0.8	1.4	-0.8	-1.2	-1.2	-0.4	0.6
Pulse rate, automated reading	0.5	1.5	5.3	0.4	-0.8	1.0	-0.6	-2.3
Alcohol intake frequency.	0.2	0.4	0.7	0.6	0.2	-0.5	-0.7	0.9
Comparative height size at age 10	0.2	1.2	2.5	-1.6	-1.2	-1.4	-0.6	-0.4
Number of full sisters	0.7	0.9	2.3	0.1	-1.5	-1.2	-0.4	-0.8
Suffer from ‘nerves’	0.1	0.2	0.8	-0.2	0.2	-0.9	-0.2	0.1
Overall health rating	0.5	1.1	3.5	0.9	-0.1	1.9	-0.0	-1.1
Chest pain or discomfort	1.6	2.2	5.1	1.9	0.9	2.3	1.2	0.7
Had major operations	0.5	0.6	1.7	-0.9	-0.6	-0.2	-0.1	-1.3
Age at last live birth	0.5	0.7	1.6	-1.0	-0.2	-1.3	-0.6	0.8
Family relationship satisfaction	0.2	0.3	1.1	-0.1	1.1	0.1	0.3	-0.5
Leg pain on walking	1.7	2.2	6.0	0.0	1.9	2.4	-0.8	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	4.9	-1.7	-2.2	-1.0	-0.6	-0.9
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.0	-0.4	-1.0	0.4	1.0	-0.5
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.4	-0.3	-0.1	-1.2	-0.4	0.6
Medication: Aspirin	2.1	2.7	4.3	-1.1	-2.1	-1.6	-1.4	-1.9
Supplements: Vitamin C	0.5	0.6	2.0	0.7	1.4	0.1	-0.7	-0.1
Knee pain experienced in last month	0.2	0.4	1.0	0.7	0.4	1.0	-0.1	-0.5
Hypertension (Self-reported)	2.0	5.5	11.2	-1.6	-2.5	-2.5	-3.4	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	3.0	-0.2	-0.8	-1.1	-0.7	-1.7
Illnesses of father: Heart disease	1.9	2.7	5.0	1.4	2.2	1.4	1.3	1.7
Illnesses of siblings: Diabetes	0.4	0.5	1.5	0.2	-0.8	0.2	0.1	-1.2
Smoking status: Previous	1.3	1.9	4.5	-1.8	-2.1	-1.3	0.2	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.3	-0.3	0.2	0.4	1.0	1.1
Whole body fat-free mass	0.1	0.8	1.3	-0.8	-1.0	-1.0	-0.1	1.1
Leg fat-free mass (right)	0.2	1.1	3.3	-0.7	-0.9	-1.0	0.0	1.8
Arm fat percentage (left)	0.4	1.8	3.8	-0.9	-0.9	-1.8	-0.3	1.9
Average weekly red wine intake	0.5	0.7	1.4	-1.2	-0.3	-0.4	-1.1	-0.9
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.9	1.4	1.3	0.5	0.4	0.1
Mood swings	0.5	0.8	3.7	-0.6	0.3	-0.2	-0.2	1.9
Loneliness, isolation	0.1	0.2	0.3	-0.4	0.4	0.0	-0.6	0.4
Long-standing illness, disability or infirmity	1.0	1.6	5.8	0.4	-0.7	1.0	-0.6	-2.4
Ever had bowel cancer screening	1.6	1.9	3.5	1.5	0.4	1.9	1.5	1.2
Diabetes diagnosed by doctor	0.1	0.2	0.6	0.6	0.1	0.3	-0.8	0.1
Ever had stillbirth, spontaneous miscarriage or termination	3.1	3.3	4.6	2.0	1.5	2.1	2.2	1.2
Friendships satisfaction	0.5	0.7	1.1	-0.9	0.6	-1.0	0.1	1.0
Qualifications: nursing, teaching	0.7	1.1	2.2	1.0	1.5	1.3	0.7	-0.5
Commuting to job workplace: Walk	0.7	0.8	2.3	0.7	1.5	0.9	-0.1	-0.5
Eye problems/disorders: Cataract	1.0	1.2	2.5	-1.6	-1.1	-0.7	-0.9	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.1	-0.1	-1.1	-0.6	-0.6	0.7
Medication for cholesterol	0.3	0.4	1.8	0.1	0.4	1.3	0.4	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.0	1.2	1.4	1.0	-0.1	0.4
Back pain experienced in last month	0.4	0.6	1.6	1.2	0.8	0.9	-0.1	-0.3
Mineral and other dietary supplements	0.6	0.8	2.3	-0.8	-0.9	-1.5	0.4	-0.1
Breast cancer (self-reported)	0.2	0.3	1.1	-1.0	-0.4	0.3	-0.0	-0.2
Asthma (self-reported)	2.0	4.0	8.2	-1.5	-2.1	-0.6	-2.2	-2.9
Osteoporosis (self-reported)	1.0	1.3	2.5	1.1	0.2	1.6	1.3	-1.0
Osteoarthritis (self-reported)	0.9	1.2	3.7	0.9	1.1	1.9	0.4	-0.5
Medication: Aspirin	2.3	3.0	4.4	-1.2	-2.1	-1.8	-1.7	-1.7
Medication: Gliclazide	1.1	1.2	2.5	0.8	0.7	1.6	1.2	0.9
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	0.8	0.1	0.5	-0.3	-1.1
Smoking status: Current	0.4	0.7	2.7	-0.2	0.7	0.3	1.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.7	-0.3	-0.0	-0.8	0.1	-0.2
Whole body water mass	0.1	0.8	1.3	-0.8	-0.9	-1.0	-0.1	1.1
Leg predicted mass (right)	0.2	1.0	2.9	-0.7	-0.9	-0.9	0.1	1.7
Arm fat mass (left)	0.4	1.7	3.4	-0.8	-1.1	-1.7	-0.2	1.8
Number of self-reported non-cancer illnesses	0.9	1.6	3.8	-0.6	-1.3	-0.3	-1.9	-1.4
Average weekly champagne plus white wine intake	0.1	0.2	0.7	0.4	0.8	0.0	0.2	-0.1
Miserableness	0.7	1.3	3.5	-0.4	0.2	-1.2	-1.1	1.9
Guilty feelings	0.3	0.4	0.9	-0.9	0.2	0.2	-0.8	0.8
Wears glasses or contact lenses	0.8	1.0	2.5	1.0	0.9	1.6	0.1	0.7
Ever taken oral contraceptive pill	0.8	0.8	2.4	0.8	1.1	-0.2	1.5	0.1
Hearing aid user	0.3	0.4	1.3	0.5	-0.2	0.2	1.1	-0.4
Mother’s age at death	0.7	0.9	2.9	-1.7	0.2	-0.2	-1.1	-0.5
Financial situation satisfaction	1.0	1.2	2.2	-1.2	-1.5	0.0	-1.0	-1.2
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.5	0.5	-0.3	0.4	-1.2	-0.4
Commuting to job workplace: Public transport	0.7	0.8	2.6	-0.4	-0.0	-1.2	-1.6	-0.1
Eye problems/disorders: Glaucoma	1.0	1.2	4.1	0.0	-1.2	0.1	-0.4	-2.0
Medication: Blood pressure	0.3	0.6	2.1	0.6	-0.1	-0.7	0.3	1.5
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.3	-0.3	0.0	0.2	-1.5	0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	0.4	0.8	1.0	-0.6	-0.5
High cholesterol (Self-reported)	0.9	1.7	3.6	-1.9	-0.8	-1.5	-1.1	-0.6
Medication: Bendroflumethiazide	0.2	0.3	0.7	-0.2	-0.7	-0.8	-0.1	0.6
Medication: Paracetamol	0.3	0.5	1.0	1.0	0.1	0.9	0.8	-0.1
Medication: Lisinopril	0.3	0.4	1.2	0.2	-1.1	0.2	-0.3	-0.7
Medication: Atorvastatin	0.6	0.8	1.8	-0.9	-0.5	-1.4	-0.0	0.9
Illnesses of father: High blood pressure	0.6	0.8	2.9	-0.5	-0.1	-0.2	0.8	1.7
Alcohol drinker status: Never	0.2	0.2	0.5	0.7	0.2	0.5	-0.3	0.2
Ever smoked	0.4	0.6	1.7	-1.3	-0.4	-0.6	0.5	-0.8
Basal metabolic rate	0.2	1.2	2.0	-1.0	-1.2	-1.3	-0.2	1.4
Leg fat percentage (left)	0.6	2.0	4.8	-0.8	-0.9	-2.2	-0.9	1.8
Arm fat-free mass (left)	0.1	0.7	1.3	-0.4	-0.9	-1.1	0.0	1.1
Number of operations (self-reported)	0.9	1.3	3.9	-2.0	-1.6	-0.0	-0.4	-0.4
Average weekly beer plus cider intake	0.2	0.3	0.8	0.1	-0.6	0.2	-0.9	0.2
Irritability	0.2	0.4	1.4	0.3	0.5	0.1	0.2	1.2
Risk taking	0.6	0.9	2.1	-1.3	-0.6	-0.5	0.0	-1.4
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.8	1.1	1.1	1.7	-0.1	-0.4
Fractured/broken bones in last 5 years	1.6	2.0	5.9	-1.9	-2.4	-0.3	-0.6	0.4
Age started oral contraceptive pill	1.1	1.4	2.7	-1.6	-1.1	-1.6	-0.4	-0.5
Diastolic blood pressure, automated reading	1.7	5.3	9.0	-2.2	-3.0	-2.6	-2.4	-0.1
Ever depressed for a whole week	1.0	1.3	3.5	-1.3	0.8	0.5	-1.9	-0.6
Unable to work because of sickness or disability	0.8	1.1	3.6	-0.5	-0.9	0.4	-0.8	-1.9
Commuting to job workplace: Cycle	1.0	1.2	4.2	-0.0	1.3	-0.5	-0.0	2.1
Myopia	0.2	0.3	0.7	-0.7	-0.9	-0.4	0.2	0.1
Vascular/heart problems diagnosed by doctor	2.6	7.0	14.6	2.0	2.6	2.9	3.8	1.0
Cholesterol lowering medication	0.2	0.3	0.6	-0.1	0.5	-0.6	0.5	0.8
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.9	-1.2	-0.5	-1.0	-2.0	-1.2
Pain experienced in last month	0.4	0.7	2.3	-0.7	-0.1	-1.5	-0.3	0.8
Supplements: Calcium	0.7	0.8	2.2	-1.5	-0.3	0.7	0.4	-1.0
Basal cell carcinoma (self-reported)	0.3	0.3	1.3	-1.1	-0.2	0.1	-0.3	-0.5
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.6	-0.1	-0.0	-1.3	0.3	1.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	0.1	-0.4	-0.2	-0.8	-0.7
Heart disease (siblings)	0.4	0.4	0.9	-0.4	-0.9	-0.4	-0.3	-1.0
Alcohol drinker status: Previous	0.4	0.4	1.2	-0.1	0.3	-0.5	-0.9	-1.1
Pack years of smoking	0.6	0.9	2.3	0.2	0.3	0.2	1.5	1.5
Impedance of whole body	0.1	0.4	0.8	-0.1	0.8	0.8	0.9	-0.1
Leg fat mass (left)	0.6	2.3	4.6	-1.2	-1.4	-2.1	-1.0	1.7
Arm predicted mass (left)	0.1	0.6	1.2	-0.5	-1.0	-1.1	-0.2	0.8