TWAS hub - TMEM175

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.4030	0.1110	3.5e-04	0.093	NA	0.158	NA	0.162	1.1e-03	NA	2.0e-05	NA	1.6e-05
2	GTEx	Nerve Tibial	0.0825	0.0364	6.4e-03	0.050	NA	0.019	NA	0.030	1.9e-04	NA	1.5e-02	NA	3.0e-03
3	GTEx	Thyroid	0.1260	0.0460	6.2e-04	0.037	NA	0.039	NA	0.055	7.6e-04	NA	5.8e-04	NA	4.9e-05
4	ROSMAP	Brain Pre-frontal Cortex	0.1417	0.0371	7.9e-10	0.033	0.084	0.070	0.081	0.049	4.3e-05	5.7e-11	2.6e-09	1.3e-10	6.6e-07
5	YFS	Blood	0.0501	0.0168	9.2e-06	0.022	0.017	0.018	0.020	0.016	5.4e-08	1.9e-06	8.4e-07	2.2e-07	4.6e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Heel bone mineral density (BMD) T-score, automated (left)	6.2	14.1	40.1	3.9	6.3	2.9	2.5	0.7
Heel T-Score	5.9	46.8	132.2	6.7	11.5	4.8	5.5	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	5.2	11.9	34.9	3.5	5.9	2.7	2.2	0.3
Waist Hip Ratio (WHR)	5.0	22.3	42.2	-4.2	-4.4	-6.5	-2.7	-5.0
Coronary Artery Disease (CAD)	4.8	5.7	8.2	-2.1	-2.9	-2.7	-2.3	-2.0
Systolic blood pressure, automated reading	4.5	13.0	20.5	-3.6	-4.3	-4.5	-3.5	-0.5
Exposure to tobacco smoke at home	4.0	4.5	6.2	2.5	1.8	2.3	2.1	1.8
Hearing difficulty/problems with background noise	3.3	5.2	8.6	1.5	2.2	2.8	1.7	2.9
Ever had stillbirth, spontaneous miscarriage or termination	3.1	3.3	4.6	2.0	1.5	2.1	2.2	1.2
Medication for cholesterol, blood pressure or diabetes	3.0	5.0	11.8	1.6	1.8	2.0	3.4	1.9
Medication: Blood pressure	3.0	5.3	12.2	-1.8	-2.1	-1.8	-3.5	-1.8
Medication for hormone replacement therapy	2.8	3.2	5.2	-1.2	-2.3	-2.1	-1.9	-1.1
Number of children fathered	2.6	2.9	5.8	1.8	1.0	2.4	2.1	0.4
Vascular/heart problems diagnosed by doctor	2.6	7.0	14.6	2.0	2.6	2.9	3.8	1.0
Number of full brothers	2.4	3.0	9.6	-0.7	-1.0	-0.3	-2.0	-3.1
Waist circumference	2.3	8.2	16.1	-3.0	-3.2	-4.0	-2.4	0.1
Gout (self-reported)	2.3	3.2	11.1	-0.9	-0.8	-0.7	-3.3	-1.6
Medication: Aspirin	2.3	3.0	4.4	-1.2	-2.1	-1.8	-1.7	-1.7
Other serious medical condition/disability diagnosed by doctor	2.2	2.9	10.7	-0.0	-0.2	1.9	-0.4	-3.3
High blood pressure	2.1	5.9	13.5	-1.7	-2.4	-2.6	-3.7	-0.6
Medication: Aspirin	2.1	2.7	4.3	-1.1	-2.1	-1.6	-1.4	-1.9
Systolic Blood Pressure	2.0	10.1	15.4	-2.9	-3.5	-3.9	-3.8	-0.5
Had menopause	2.0	2.5	4.4	-1.9	-2.1	-1.9	-0.2	-0.7
Number of live births	2.0	2.8	5.2	-1.6	-1.9	-2.3	-1.3	-0.8
Medication: Amlodipine	2.0	2.8	5.4	-2.3	-1.9	-2.1	-0.9	0.2
Hypertension (Self-reported)	2.0	5.5	11.2	-1.6	-2.5	-2.5	-3.4	-1.0
Asthma (self-reported)	2.0	4.0	8.2	-1.5	-2.1	-0.6	-2.2	-2.9
Illnesses of father: Heart disease	1.9	2.7	5.0	1.4	2.2	1.4	1.3	1.7
Triglycerides	1.8	3.0	10.2	-0.9	-1.7	-0.9	-0.4	-3.2
Cardiovascular Disease	1.8	6.0	11.0	-2.0	-1.7	-3.3	-3.3	-1.1
Diabetes (mother)	1.8	2.3	5.5	-1.5	-2.3	-1.1	-1.4	-0.9
Hair/balding pattern: Pattern 4	1.8	4.3	5.3	2.3	2.3	2.2	1.9	1.5
Number of incorrect matches in round	1.7	2.9	6.4	1.9	2.5	2.0	0.6	0.3
Medication: Seretide 50 evohaler	1.7	1.9	3.4	-1.8	-1.6	0.1	-1.4	-1.2
Leg pain on walking	1.7	2.2	6.0	0.0	1.9	2.4	-0.8	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	4.9	-1.7	-2.2	-1.0	-0.6	-0.9
Diastolic blood pressure, automated reading	1.7	5.3	9.0	-2.2	-3.0	-2.6	-2.4	-0.1
Alcohol intake versus 10 years previously	1.6	2.4	5.5	-1.1	-1.7	-2.3	-1.5	-0.0
Medication: Cholesterol lowering	1.6	2.4	6.8	-1.0	-1.1	-1.4	-2.6	-1.1
Chest pain or discomfort	1.6	2.2	5.1	1.9	0.9	2.3	1.2	0.7
Ever had bowel cancer screening	1.6	1.9	3.5	1.5	0.4	1.9	1.5	1.2
Fractured/broken bones in last 5 years	1.6	2.0	5.9	-1.9	-2.4	-0.3	-0.6	0.4
Breast Cancer	1.5	3.5	6.2	-2.3	-1.2	-2.1	-2.5	-0.3
Average weekly spirits intake	1.5	1.9	3.7	1.1	1.9	1.7	1.2	0.2
Pain all over the body in last month	1.5	1.6	3.5	1.0	0.5	1.9	1.8	0.1
Asthma	1.5	3.0	6.2	-1.2	-2.1	-0.5	-1.7	-2.5
Shortness of breath walking on level ground	1.5	1.8	3.7	-1.1	-0.7	0.0	-1.9	-1.9
Primary Biliary Cirrhosis	1.4	1.9	4.3	1.9	1.1	2.1	0.4	-0.5
Ulcerative Colitis	1.4	2.0	5.1	-1.2	-0.8	-1.6	-2.3	0.4
Number of treatments/medications taken	1.4	2.6	4.9	-1.0	-2.0	-0.7	-2.2	-1.5
Taking other prescription medications	1.4	2.2	4.1	-1.2	-1.7	-0.4	-2.0	-1.6
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	3.6	-0.7	-1.3	-0.4	-1.4	-1.9
Medication: Omeprazole	1.4	1.6	4.4	-0.8	-0.3	-0.2	-2.1	-1.7
Medication: Co-codamol	1.3	1.4	3.2	-1.6	-1.8	-0.1	0.1	-1.2
Health satisfaction	1.3	1.7	4.8	-1.0	-0.3	0.8	-1.3	-2.2
Smoking status: Previous	1.3	1.9	4.5	-1.8	-2.1	-1.3	0.2	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.9	-1.2	-0.5	-1.0	-2.0	-1.2
Mouth/teeth dental problems: Dentures	1.2	2.0	3.5	-1.8	-1.7	-1.9	0.5	-0.4
Prospective memory result	1.2	1.4	3.8	-1.2	-0.5	-1.1	-1.9	-0.5
Pulse wave peak to peak time	1.2	1.4	4.2	0.2	1.1	0.0	1.2	2.0
Medication: Allopurinol	1.2	1.5	5.1	-0.2	0.4	0.8	-2.2	-1.3
Ovarian Cancer	1.1	1.4	3.5	-1.9	-0.4	-0.6	-1.2	-1.2
Relative age of first facial hair	1.1	2.2	5.0	-2.1	-1.3	-2.2	0.1	0.1
Hair/balding pattern: Pattern 3	1.1	1.6	2.9	-1.2	-0.8	-1.7	-1.3	-1.2
Medication: Gliclazide	1.1	1.2	2.5	0.8	0.7	1.6	1.2	0.9
Age started oral contraceptive pill	1.1	1.4	2.7	-1.6	-1.1	-1.6	-0.4	-0.5
Chronotype (morning person)	1.0	2.2	5.2	0.9	2.2	0.1	-2.3	0.3
Pulse wave Arterial Stiffness index	1.0	1.1	3.8	0.0	-1.0	0.3	-1.0	-1.9
Qualifications: O levels/GCSEs or equivalent	1.0	1.7	4.1	-0.3	-0.0	-0.8	-1.8	-2.0
Migraine (self-reported)	1.0	1.2	2.4	-0.6	-0.9	-1.6	-1.5	0.1
Long-standing illness, disability or infirmity	1.0	1.6	5.8	0.4	-0.7	1.0	-0.6	-2.4
Eye problems/disorders: Cataract	1.0	1.2	2.5	-1.6	-1.1	-0.7	-0.9	-0.9
Osteoporosis (self-reported)	1.0	1.3	2.5	1.1	0.2	1.6	1.3	-1.0
Financial situation satisfaction	1.0	1.2	2.2	-1.2	-1.5	0.0	-1.0	-1.2
Eye problems/disorders: Glaucoma	1.0	1.2	4.1	0.0	-1.2	0.1	-0.4	-2.0
Ever depressed for a whole week	1.0	1.3	3.5	-1.3	0.8	0.5	-1.9	-0.6
Commuting to job workplace: Cycle	1.0	1.2	4.2	-0.0	1.3	-0.5	-0.0	2.1
Smoking Status	0.9	2.1	6.0	-1.3	-1.4	-1.0	2.4	0.2
Hearing difficulty/problems: Yes	0.9	1.3	2.6	0.7	0.3	1.5	1.0	1.6
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.8	-0.9	-1.7	-1.2	0.1	-0.6
Pack years adult smoking proportion	0.9	1.3	3.1	0.3	0.5	0.5	1.8	1.7
Mouth/teeth dental problems	0.9	1.4	2.5	1.5	1.4	1.6	-0.5	-0.3
Birth weight of first child	0.9	1.7	5.0	-1.5	-0.3	-2.2	0.2	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	3.0	-0.2	-0.8	-1.1	-0.7	-1.7
Osteoarthritis (self-reported)	0.9	1.2	3.7	0.9	1.1	1.9	0.4	-0.5
Number of self-reported non-cancer illnesses	0.9	1.6	3.8	-0.6	-1.3	-0.3	-1.9	-1.4
High cholesterol (Self-reported)	0.9	1.7	3.6	-1.9	-0.8	-1.5	-1.1	-0.6
Number of operations (self-reported)	0.9	1.3	3.9	-2.0	-1.6	-0.0	-0.4	-0.4
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.8	1.1	1.1	1.7	-0.1	-0.4
Mean Putamen Volume	0.8	0.9	1.4	1.2	0.1	0.7	1.1	-1.2
HDL Cholesterol	0.8	1.3	1.9	0.5	1.1	1.1	1.3	1.4
Relative age voice broke	0.8	1.2	5.2	-0.3	-0.7	-0.4	2.3	-0.3
Qualifications: CSEs or equivalent	0.8	1.1	3.0	-0.8	-0.1	-1.7	0.6	1.1
Hair/balding pattern: Pattern 2	0.8	1.0	1.9	-0.5	-1.2	-1.4	-0.9	0.7
Medication: Simvastatin	0.8	1.2	4.0	-0.8	-0.5	-0.7	-2.0	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.1	-1.4	-1.4	-0.3	-0.4	0.7
Illnesses of mother	0.8	1.0	1.5	0.9	1.2	1.1	0.9	0.9
Loud music exposure frequency	0.8	0.9	1.8	-1.4	-0.8	-1.1	-0.8	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.0	1.2	1.4	1.0	-0.1	0.4
Wears glasses or contact lenses	0.8	1.0	2.5	1.0	0.9	1.6	0.1	0.7
Ever taken oral contraceptive pill	0.8	0.8	2.4	0.8	1.1	-0.2	1.5	0.1
Unable to work because of sickness or disability	0.8	1.1	3.6	-0.5	-0.9	0.4	-0.8	-1.9
Reaction Time	0.7	1.3	3.7	0.8	1.4	1.9	0.2	0.3
LDL Cholesterol	0.7	1.1	2.3	1.1	1.2	0.1	1.5	-0.8
Townsend deprivation index at recruitment	0.7	1.0	2.7	-0.3	-1.1	-1.6	-0.8	-0.5
Average weekly fortified wine intake	0.7	0.8	2.0	-1.4	-0.5	0.3	-0.3	-1.2
Maternal smoking around birth	0.7	0.9	1.6	0.9	0.2	1.2	1.3	0.9
Medication: Levothyroxine sodium	0.7	1.2	4.7	0.9	0.5	0.1	0.2	2.2
Past tobacco smoking	0.7	1.3	2.5	1.6	1.2	1.0	-0.7	0.9
Had other major operations	0.7	0.9	2.1	-1.4	-1.4	-0.4	-0.1	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	4.7	-0.2	0.8	0.5	0.4	2.2
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.1	0.0	1.0	1.4	0.1	0.9
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.4	-1.1	-0.9	-0.7	-0.9	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.3	1.1	0.5	0.5	0.2	1.5
Eye problems/disorders: None of the above	0.7	0.8	2.0	-0.8	-0.5	-1.4	-0.3	0.9
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.5	-1.2	-0.5	-0.7	-1.2	0.8
Number of full sisters	0.7	0.9	2.3	0.1	-1.5	-1.2	-0.4	-0.8
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.9	1.4	1.3	0.5	0.4	0.1
Qualifications: nursing, teaching	0.7	1.1	2.2	1.0	1.5	1.3	0.7	-0.5
Commuting to job workplace: Walk	0.7	0.8	2.3	0.7	1.5	0.9	-0.1	-0.5
Miserableness	0.7	1.3	3.5	-0.4	0.2	-1.2	-1.1	1.9
Mother’s age at death	0.7	0.9	2.9	-1.7	0.2	-0.2	-1.1	-0.5
Commuting to job workplace: Public transport	0.7	0.8	2.6	-0.4	-0.0	-1.2	-1.6	-0.1
Supplements: Calcium	0.7	0.8	2.2	-1.5	-0.3	0.7	0.4	-1.0
Body Mass Index (BMI) (2010)	0.6	0.9	1.8	-0.7	-1.0	-1.0	0.2	-1.4
HbA1C	0.6	0.7	1.3	-0.8	-1.0	-0.6	-1.1	0.0
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.8	0.0	-1.7	-0.7	-0.5	-0.3
Lung FEV1/FVC ratio	0.6	3.2	9.9	-1.5	-0.5	-3.1	-1.9	0.1
Sensitivity / hurt feelings	0.6	1.0	2.5	0.2	-0.3	-0.7	-1.4	1.6
Ever had hysterectomy (womb removed)	0.6	0.6	1.6	0.8	-0.5	0.8	1.3	0.1
Supplements: Zinc	0.6	0.6	1.9	-0.5	0.9	-0.3	0.5	-1.4
Severe depression (siblings)	0.6	0.7	2.3	-0.6	-1.5	-0.3	-0.6	-0.7
Current tobacco smoking	0.6	0.9	3.0	0.1	0.9	0.7	1.7	0.5
Fed-up feelings	0.6	1.0	4.5	-0.3	-0.2	-0.5	-0.6	2.1
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.2	-1.2	-0.7	-1.1	-1.8	-0.4
Medication: Atenolol	0.6	0.7	1.7	1.2	-0.0	0.1	-0.6	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.0	-0.9	-1.2	-1.4	-0.8	-0.1
Allergy	0.6	1.3	3.1	1.1	0.9	0.6	1.8	1.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.5	-1.0	-0.8	0.1	-1.2	-1.0
Medication: Ramipril	0.6	0.8	1.3	-0.6	-1.0	-1.1	-0.5	-0.9
Neuroticism score	0.6	1.2	3.6	-0.4	0.4	-0.5	-1.4	1.9
Hip circumference	0.6	2.4	6.9	-1.1	-1.3	-1.1	-1.0	2.6
Breastfed as a baby	0.6	0.8	1.2	-1.1	0.1	-0.8	-0.9	-1.0
Exposure to tobacco smoke outside home	0.6	0.9	2.0	-0.7	-0.7	-0.5	-1.0	-1.4
Neck or shoulder pain in last month	0.6	0.8	3.0	0.4	0.0	1.7	-0.5	-0.8
Heart disease (mother)	0.6	0.7	1.4	-0.7	0.0	-1.1	-1.2	-0.5
Mineral and other dietary supplements	0.6	0.8	2.3	-0.8	-0.9	-1.5	0.4	-0.1
Medication: Atorvastatin	0.6	0.8	1.8	-0.9	-0.5	-1.4	-0.0	0.9
Illnesses of father: High blood pressure	0.6	0.8	2.9	-0.5	-0.1	-0.2	0.8	1.7
Leg fat percentage (left)	0.6	2.0	4.8	-0.8	-0.9	-2.2	-0.9	1.8
Risk taking	0.6	0.9	2.1	-1.3	-0.6	-0.5	0.0	-1.4
Pack years of smoking	0.6	0.9	2.3	0.2	0.3	0.2	1.5	1.5
Leg fat mass (left)	0.6	2.3	4.6	-1.2	-1.4	-2.1	-1.0	1.7
Depressed Affect (Nagel 2018)	0.5	1.0	4.0	-0.5	0.3	-0.3	-0.7	2.0
Intelligence (Savage-Jansen 2018)	0.5	1.4	3.1	-1.2	-1.0	-0.9	-0.9	-1.8
Alzheimer’s Disease (in mother)	0.5	0.6	2.2	-0.0	-0.9	-0.3	0.3	-1.5
Alzheimer’s Disease (including proxy)	0.5	0.8	1.9	0.1	-0.6	0.1	1.4	-1.2
Major Depression (MDD)	0.5	0.6	1.7	0.0	0.9	0.0	-0.7	-1.3
Prostate Cancer	0.5	0.7	3.3	0.3	-0.2	0.5	1.8	-0.1
Lupus	0.5	0.7	2.0	0.6	0.3	0.8	1.4	0.6
Allergy or Eczema	0.5	1.4	5.0	-1.1	-0.3	-0.7	-2.2	-0.4
Respiratory disease	0.5	1.0	1.8	-1.0	-1.2	0.3	-1.0	-1.3
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.1	1.4	0.8	0.2	-1.2	-0.0
Lung FVC	0.5	2.4	3.8	1.7	2.0	1.7	1.5	-0.1
Medication: Metformin	0.5	0.7	2.0	1.4	0.1	0.2	-0.1	1.1
Trunk fat percentage	0.5	2.1	3.6	-1.2	-1.5	-1.9	-0.5	1.8
Age when periods started (menarche)	0.5	1.1	4.8	-0.9	0.0	-0.2	0.2	-2.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.1	0.1	-0.7	0.8	0.9	-1.1
High blood pressure (mother)	0.5	0.7	1.5	-0.4	-1.1	-0.8	-0.4	1.2
Trunk fat mass	0.5	1.9	3.2	-1.2	-1.4	-1.8	-0.3	1.8
Heart attack	0.5	0.6	1.5	-0.2	-0.1	-1.2	0.3	1.2
Fluid intelligence score	0.5	1.1	2.2	-0.2	-0.7	-1.2	-1.5	-1.2
Time employed in main current job	0.5	0.5	1.8	-0.6	0.5	0.5	0.1	1.4
Worrier / anxious feelings	0.5	0.9	4.1	-0.0	0.4	0.0	-2.0	0.4
Tense / ‘highly strung’	0.5	0.8	1.4	-1.2	-0.8	-1.1	-1.0	0.2
Glaucoma (self-reported)	0.5	0.6	1.8	-0.2	-0.8	0.3	-0.4	-1.4
Body fat percentage	0.5	2.1	4.0	-1.1	-1.2	-2.0	-0.5	1.9
Leg fat percentage (right)	0.5	1.6	3.6	-0.9	-0.8	-1.9	-0.6	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.1	0.6	0.8	0.9	0.7	1.1
Whole body fat mass	0.5	2.0	3.3	-1.1	-1.4	-1.8	-0.5	1.8
Leg fat mass (right)	0.5	1.9	3.5	-1.1	-1.2	-1.9	-0.8	1.6
Pulse rate, automated reading	0.5	1.5	5.3	0.4	-0.8	1.0	-0.6	-2.3
Overall health rating	0.5	1.1	3.5	0.9	-0.1	1.9	-0.0	-1.1
Had major operations	0.5	0.6	1.7	-0.9	-0.6	-0.2	-0.1	-1.3
Age at last live birth	0.5	0.7	1.6	-1.0	-0.2	-1.3	-0.6	0.8
Supplements: Vitamin C	0.5	0.6	2.0	0.7	1.4	0.1	-0.7	-0.1
Average weekly red wine intake	0.5	0.7	1.4	-1.2	-0.3	-0.4	-1.1	-0.9
Mood swings	0.5	0.8	3.7	-0.6	0.3	-0.2	-0.2	1.9
Friendships satisfaction	0.5	0.7	1.1	-0.9	0.6	-1.0	0.1	1.0
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.3	-0.3	0.0	0.2	-1.5	0.8
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.6	-0.1	-0.0	-1.3	0.3	1.2
Bipolar Disorder (2018)	0.4	0.6	2.6	-0.2	-0.0	0.1	-0.7	-1.6
Bipolar Disorder or Schizophrenia	0.4	0.9	2.3	0.8	0.1	0.7	-1.0	-1.5
Neuroticism (Nagel 2018)	0.4	0.9	2.9	0.5	0.7	0.1	-0.9	1.7
Schizophrenia vs Biploar Disorder	0.4	0.5	2.0	-0.0	-0.1	-0.3	-1.4	-0.5
Crohns Disease (2012)	0.4	0.6	1.5	-0.0	-0.3	-0.2	-1.1	-1.2
Schizophrenia (2014)	0.4	0.8	1.8	1.1	0.2	0.7	-1.3	-0.8
Blood White Count	0.4	3.1	8.4	0.9	0.6	1.7	-1.8	-2.9
Hypothyroidism (self reported)	0.4	0.8	1.6	-0.5	-0.5	-1.1	-0.8	1.3
Neuroticism	0.4	0.9	2.6	-0.4	-0.1	-0.9	-1.0	1.6
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	2.1	0.3	-0.2	0.0	0.0	1.4
Angina	0.4	0.6	1.4	-0.7	-0.0	-0.2	-1.2	-0.9
Vitamin and mineral supplements	0.4	0.6	0.8	-0.3	-0.8	-0.9	0.9	0.8
Hand grip strength (right)	0.4	1.2	2.1	-1.5	-0.4	-1.3	-0.3	1.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	0.0	1.1	0.9	-0.1	-0.1
Body mass index (BMI)	0.4	1.7	3.9	-0.4	-1.0	-1.7	-0.7	2.0
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	0.9	-0.4	0.9	0.5	-0.9	-0.2
Qualifications: None of the above	0.4	0.8	1.8	1.2	0.4	1.3	0.6	0.2
Financial difficulties in last 2 years	0.4	0.6	1.9	-0.6	0.2	1.4	-0.2	0.6
Weight	0.4	2.1	4.2	-1.1	-1.3	-1.8	-0.4	2.1
Arm fat percentage (right)	0.4	1.5	4.0	-0.5	-0.6	-1.6	0.1	2.0
Medication: Lansoprazole	0.4	0.5	1.8	0.0	-0.5	-0.1	1.4	0.6
Arm fat mass (right)	0.4	1.6	3.7	-0.6	-1.0	-1.6	-0.1	1.9
Headache pain in last month	0.4	0.7	1.4	1.1	-0.1	0.8	1.2	-0.3
High blood pressure (siblings)	0.4	0.6	1.7	0.4	-0.5	-0.7	-1.3	0.6
Age at first live birth	0.4	0.8	2.5	0.1	1.2	0.0	-0.2	1.6
Emphysema/chronic bronchitis	0.4	0.5	0.8	0.4	0.9	0.7	0.7	-0.7
Mean time to correctly identify matches	0.4	0.9	2.6	0.7	1.1	1.6	-0.1	-0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.0	-0.4	-1.0	0.4	1.0	-0.5
Illnesses of siblings: Diabetes	0.4	0.5	1.5	0.2	-0.8	0.2	0.1	-1.2
Arm fat percentage (left)	0.4	1.8	3.8	-0.9	-0.9	-1.8	-0.3	1.9
Back pain experienced in last month	0.4	0.6	1.6	1.2	0.8	0.9	-0.1	-0.3
Smoking status: Current	0.4	0.7	2.7	-0.2	0.7	0.3	1.6	0.2
Arm fat mass (left)	0.4	1.7	3.4	-0.8	-1.1	-1.7	-0.2	1.8
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.5	0.5	-0.3	0.4	-1.2	-0.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	0.4	0.8	1.0	-0.6	-0.5
Ever smoked	0.4	0.6	1.7	-1.3	-0.4	-0.6	0.5	-0.8
Pain experienced in last month	0.4	0.7	2.3	-0.7	-0.1	-1.5	-0.3	0.8
Heart disease (siblings)	0.4	0.4	0.9	-0.4	-0.9	-0.4	-0.3	-1.0
Alcohol drinker status: Previous	0.4	0.4	1.2	-0.1	0.3	-0.5	-0.9	-1.1
Schizophrenia (2018)	0.3	0.6	1.5	1.2	0.1	0.8	-0.7	-0.7
Worry (Nagel 2018)	0.3	0.7	1.9	0.6	0.6	-0.2	-1.4	0.9
Ulcerative Colitis (UC)	0.3	0.5	1.5	0.2	0.3	0.2	-0.8	1.2
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.0	0.9	0.1	0.5	-0.1	-1.4
Age at First Birth	0.3	0.5	1.5	0.7	0.5	0.3	-0.3	1.2
Neuroticism (2016)	0.3	0.4	1.3	-0.3	-0.2	0.3	0.7	1.1
Rheumatoid Arthritis	0.3	0.5	1.1	0.1	-0.5	0.8	0.6	-1.0
Blood Platelet Count	0.3	3.1	5.8	2.4	1.6	2.2	1.4	0.7
BMI	0.3	1.7	3.6	-0.7	-1.2	-1.9	-0.8	1.6
Hand grip strength (left)	0.3	0.7	2.5	-1.6	-0.5	-0.7	-0.5	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.2	-0.3	0.4	0.5	0.3	1.1
Serious illness, injury or assault to yourself	0.3	0.4	0.8	-0.6	-0.3	0.9	-0.7	-0.6
Father’s age at death	0.3	0.4	1.5	-1.2	-0.4	0.1	-0.6	-0.4
Pulse rate	0.3	0.5	2.0	0.0	-0.4	1.4	-0.1	-0.6
Noisy workplace	0.3	0.4	0.9	-0.9	-0.7	0.4	-0.6	0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.9	0.7	0.5	0.2	-0.9	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.5	0.3	-0.2	-0.1	1.2	0.4
Lung cancer (father)	0.3	0.3	0.7	0.1	-0.3	-0.7	-0.6	-0.8
Length of working week for main job	0.3	0.4	1.0	-1.0	0.3	-0.8	-0.0	0.1
Pulse wave reflection index	0.3	0.3	1.0	0.8	-0.2	0.0	1.0	0.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.2	0.2	1.1	0.6	0.6	-0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	2.2	0.3	-0.1	-0.4	0.4	1.5
Comparative body size at age 10	0.3	0.8	2.0	-0.8	0.2	-0.8	-1.4	0.6
Worry too long after embarrassment	0.3	0.5	1.3	0.9	1.1	-0.0	-0.3	0.6
Qualifications: College or University degree	0.3	0.9	3.5	0.3	1.9	0.5	0.2	0.9
Medication for pain relief, constipation, heartburn	0.3	0.4	2.0	0.5	1.4	0.0	-0.2	0.2
Angina (self-reported)	0.3	0.4	1.0	-0.7	-0.0	-0.1	-1.0	-0.8
Medication: Ibuprofen	0.3	0.3	0.6	-0.2	-0.4	0.7	0.6	0.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.4	-0.3	-0.1	-1.2	-0.4	0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.1	-0.1	-1.1	-0.6	-0.6	0.7
Medication for cholesterol	0.3	0.4	1.8	0.1	0.4	1.3	0.4	-0.2
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	0.8	0.1	0.5	-0.3	-1.1
Guilty feelings	0.3	0.4	0.9	-0.9	0.2	0.2	-0.8	0.8
Hearing aid user	0.3	0.4	1.3	0.5	-0.2	0.2	1.1	-0.4
Medication: Blood pressure	0.3	0.6	2.1	0.6	-0.1	-0.7	0.3	1.5
Medication: Paracetamol	0.3	0.5	1.0	1.0	0.1	0.9	0.8	-0.1
Medication: Lisinopril	0.3	0.4	1.2	0.2	-1.1	0.2	-0.3	-0.7
Basal cell carcinoma (self-reported)	0.3	0.3	1.3	-1.1	-0.2	0.1	-0.3	-0.5
Depression (Nagel 2018)	0.2	0.3	1.2	-0.1	0.1	0.3	-1.1	0.4
Alzheimer’s Disease (in father)	0.2	0.2	0.5	-0.7	-0.0	-0.4	0.5	0.1
Crohns Disease (2017)	0.2	0.5	1.1	0.5	0.7	0.8	0.3	-1.0
Height	0.2	3.8	9.2	-3.0	-2.5	-1.3	-0.2	-1.3
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.3	-0.5	0.2	-0.1	-1.1	0.0
Leg fat-free mass (left)	0.2	1.0	3.7	-0.6	-0.7	-0.6	0.2	1.9
Stomach or abdominal pain in last month	0.2	0.2	0.6	-0.7	0.5	0.3	-0.4	0.1
Supplements: Glucosamine	0.2	0.3	0.7	0.7	0.5	-0.4	-0.1	0.8
Chronic bronchitis/emphysema (father)	0.2	0.3	1.0	0.3	-0.4	-1.0	-0.1	-0.3
Leg predicted mass (left)	0.2	1.2	3.3	-0.8	-1.0	-0.9	-0.0	1.8
Alcohol usually taken with meals	0.2	0.3	1.2	0.0	0.4	-0.2	-1.1	-0.2
Nervous feelings	0.2	0.4	1.0	-0.1	-0.1	-0.6	-0.8	1.0
Forced vital capacity (FVC)	0.2	0.6	1.7	0.7	1.3	0.8	0.1	-0.4
Diabetes (self-reported)	0.2	0.3	0.6	0.8	-0.5	-0.3	-0.7	-0.5
Illnesses of siblings	0.2	0.3	0.6	-0.7	0.1	0.0	0.6	0.8
Impedance of arm (right)	0.2	0.9	1.9	0.0	0.9	1.0	1.4	0.6
Falls in the last year	0.2	0.3	0.6	-0.5	-0.4	0.8	-0.6	0.1
Medication: Paracetamol	0.2	0.3	0.9	0.5	-0.2	0.6	0.9	0.3
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.2	0.2	0.1	-0.4	0.2	1.1
Arm fat-free mass (right)	0.2	1.1	1.9	-1.0	-1.4	-1.4	-0.7	0.6
Arm predicted mass (right)	0.2	0.8	1.4	-0.8	-1.2	-1.2	-0.4	0.6
Alcohol intake frequency.	0.2	0.4	0.7	0.6	0.2	-0.5	-0.7	0.9
Comparative height size at age 10	0.2	1.2	2.5	-1.6	-1.2	-1.4	-0.6	-0.4
Family relationship satisfaction	0.2	0.3	1.1	-0.1	1.1	0.1	0.3	-0.5
Knee pain experienced in last month	0.2	0.4	1.0	0.7	0.4	1.0	-0.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.3	-0.3	0.2	0.4	1.0	1.1
Leg fat-free mass (right)	0.2	1.1	3.3	-0.7	-0.9	-1.0	0.0	1.8
Breast cancer (self-reported)	0.2	0.3	1.1	-1.0	-0.4	0.3	-0.0	-0.2
Leg predicted mass (right)	0.2	1.0	2.9	-0.7	-0.9	-0.9	0.1	1.7
Medication: Bendroflumethiazide	0.2	0.3	0.7	-0.2	-0.7	-0.8	-0.1	0.6
Alcohol drinker status: Never	0.2	0.2	0.5	0.7	0.2	0.5	-0.3	0.2
Basal metabolic rate	0.2	1.2	2.0	-1.0	-1.2	-1.3	-0.2	1.4
Average weekly beer plus cider intake	0.2	0.3	0.8	0.1	-0.6	0.2	-0.9	0.2
Irritability	0.2	0.4	1.4	0.3	0.5	0.1	0.2	1.2
Myopia	0.2	0.3	0.7	-0.7	-0.9	-0.4	0.2	0.1
Cholesterol lowering medication	0.2	0.3	0.6	-0.1	0.5	-0.6	0.5	0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	0.1	-0.4	-0.2	-0.8	-0.7
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	0.1	0.6	0.3	-0.7	0.3
Fasting Glucose	0.1	0.2	0.3	0.5	-0.1	0.6	0.3	0.2
Blood Eosinophil Count	0.1	0.9	3.1	-0.1	-1.0	0.6	-0.0	-1.8
Hair Pigment	0.1	2.6	4.5	1.9	1.6	2.1	0.0	1.6
Tanning	0.1	1.4	4.5	0.5	0.8	2.1	1.2	0.5
Diabetes (father)	0.1	0.2	0.5	0.2	-0.1	0.4	0.4	0.7
Impedance of leg (right)	0.1	0.3	0.9	-0.7	0.4	0.0	0.0	-0.9
Multivitamins +/- minerals	0.1	0.1	0.3	-0.2	0.3	0.2	-0.2	-0.6
Sitting height	0.1	0.4	1.3	-0.1	-0.0	0.6	0.6	1.1
Impedance of leg (left)	0.1	0.4	1.1	-0.7	0.2	-0.4	-0.3	-1.0
Trunk fat-free mass	0.1	0.6	0.9	-0.9	-0.9	-1.0	-0.2	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	-0.4	-0.2	0.8	-0.5	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.5	0.2	0.7	-0.2	-0.5	0.1
Happiness	0.1	0.1	0.4	-0.5	0.6	0.1	0.2	0.0
Depression (self-reported)	0.1	0.2	0.4	-0.1	0.1	-0.7	-0.3	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.6	-0.3	0.2	-0.6	0.1	0.8
Impedance of arm (left)	0.1	0.4	0.9	-0.5	0.5	0.6	1.0	0.4
Trunk predicted mass	0.1	0.6	0.8	-0.9	-0.9	-0.9	-0.1	0.6
Standing height	0.1	0.9	3.0	-1.7	-0.8	-0.3	0.7	0.3
Peak expiratory flow (PEF)	0.1	0.1	0.3	-0.1	0.6	0.1	0.2	0.6
Blood clot in the leg (DVT)	0.1	0.1	0.3	0.3	-0.2	0.0	-0.5	-0.5
Birth weight	0.1	0.2	0.6	-0.8	0.2	0.2	0.4	-0.6
Wheeze or whistling in the chest in last year	0.1	0.2	0.6	-0.1	-0.1	0.8	-0.4	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	-0.1	-0.4	0.2	-0.3	-0.7
Suffer from ‘nerves’	0.1	0.2	0.8	-0.2	0.2	-0.9	-0.2	0.1
Whole body fat-free mass	0.1	0.8	1.3	-0.8	-1.0	-1.0	-0.1	1.1
Loneliness, isolation	0.1	0.2	0.3	-0.4	0.4	0.0	-0.6	0.4
Diabetes diagnosed by doctor	0.1	0.2	0.6	0.6	0.1	0.3	-0.8	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.7	-0.3	-0.0	-0.8	0.1	-0.2
Whole body water mass	0.1	0.8	1.3	-0.8	-0.9	-1.0	-0.1	1.1
Average weekly champagne plus white wine intake	0.1	0.2	0.7	0.4	0.8	0.0	0.2	-0.1
Arm fat-free mass (left)	0.1	0.7	1.3	-0.4	-0.9	-1.1	0.0	1.1
Impedance of whole body	0.1	0.4	0.8	-0.1	0.8	0.8	0.9	-0.1
Arm predicted mass (left)	0.1	0.6	1.2	-0.5	-1.0	-1.1	-0.2	0.8
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.0	0.4	0.9	0.4	0.5	0.7	-0.5	1.0
Forced vital capacity (FVC), Best measure	0.0	0.1	0.2	-0.1	0.4	-0.1	0.2	0.2

Hub : Genes

TMEM175

Models

Trait associations