[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (right) : ← →

chr22:27,675,538-30,261,219

Best TWAS P=6.78e-23 · Best GWAS P=5.79e-23 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	KREMEN1	0.12	0.06	bslmm	410	0.08	2.8e-10	7.25	5.6	1.8e-08	0.63	0.18	0.82	FALSE
2	GTEx	Adipose Subcutaneous	KREMEN1	0.19	0.13	enet	22	0.13	9.2e-11	9.85	8.4	6.2e-17	0.87	0.00	1.00	TRUE
3	GTEx	Adrenal Gland	KREMEN1	0.38	0.26	lasso	3	0.22	1.7e-08	9.85	9.6	9.7e-22	0.98	0.00	1.00	FALSE
4	GTEx	Breast Mammary Tissue	KREMEN1	0.14	0.06	enet	10	0.10	6.9e-06	7.50	7.9	1.9e-15	0.85	0.01	0.98	TRUE
5	GTEx	Breast Mammary Tissue (Male)	KREMEN1	0.08	-0.01	enet	2	-0.01	4.9e-01	5.71	5.6	1.9e-08	0.62	0.03	0.29	TRUE
6	GTEx	Heart Left Ventricle	KREMEN1	0.47	0.32	lasso	6	0.34	5.0e-19	8.54	9.3	1.9e-20	0.96	0.01	0.99	FALSE
7	GTEx	Ovary	KREMEN1	0.28	0.18	enet	5	0.19	1.7e-05	8.54	8.8	1.8e-18	0.87	0.04	0.82	TRUE
8	GTEx	Pancreas	KREMEN1	0.33	0.24	lasso	7	0.23	4.2e-10	9.87	9.6	1.2e-21	0.99	0.00	1.00	FALSE
9	GTEx	Testis	TTC28	0.29	0.04	lasso	19	0.05	2.6e-03	-5.29	-5.2	1.8e-07	-0.12	0.70	0.02	TRUE
10	GTEx	Thyroid	KREMEN1	0.10	0.09	lasso	3	0.08	1.3e-06	9.86	9.9	6.8e-23	1.00	0.00	1.00	TRUE
11	METSIM	Adipose	KREMEN1	0.12	0.12	lasso	8	0.11	1.7e-16	9.63	9.7	2.6e-22	0.97	0.00	1.00	FALSE
12	YFS	Blood	KREMEN1	0.10	0.10	enet	14	0.10	1.3e-32	6.80	-6.2	7.5e-10	-0.65	1.00	0.00	TRUE
13	The Cancer Genome Atlas	Colon Adenocarcinoma	C22orf31	0.07	0.02	blup	64	0.06	2.7e-04	4.06	5.1	3.0e-07	0.64	0.04	0.50	TRUE
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KREMEN1	0.13	0.10	lasso	5	0.11	3.3e-12	8.53	9.2	2.9e-20	0.93	0.04	0.96	FALSE
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	XBP1	0.04	0.03	enet	19	0.02	1.3e-03	-4.63	5.7	1.0e-08	-0.07	0.01	0.88	TRUE
16	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ZNRF3	0.44	-0.01	blup	126	0.05	2.0e-02	-0.56	7.1	9.8e-13	0.62	0.01	0.24	FALSE